What is Flagyl used for. How effective is Flagyl for bacterial infections. What are the common side effects of Flagyl. How does Flagyl compare to other antibiotics. What precautions should be taken when using Flagyl.

Overview of Flagyl (Metronidazole)

Flagyl, also known by its generic name metronidazole, is an antibiotic medication commonly prescribed to treat various bacterial and parasitic infections. It belongs to a class of drugs called nitroimidazoles and works by stopping the growth of certain bacteria and parasites.

Based on user reviews from Drugs.com, Flagyl has an average rating of 6.2 out of 10 from a total of 383 reviews. 48% of reviewers reported a positive experience, while 28% reported a negative experience. For bacterial infections specifically, Flagyl has an average rating of 5.9 out of 10 from 212 reviews, with 43% reporting a positive experience and 32% reporting a negative experience.

Conditions Treated by Flagyl

Flagyl is used to treat a wide range of infections, including:

• Bacterial infections
• Amebiasis
• Trichomoniasis
• Giardiasis
• Helicobacter pylori infections
• Clostridioides difficile infections
• Dental abscesses
• Diverticulitis
• Pelvic inflammatory disease
• Intra-abdominal infections
• Skin and soft tissue infections

Effectiveness of Flagyl for Bacterial Infections

How effective is Flagyl in treating bacterial infections? According to user reviews, Flagyl shows moderate effectiveness in treating bacterial infections. With an average rating of 5.9 out of 10 for this condition, it appears to be helpful for many patients, but not universally effective.

The effectiveness of Flagyl can vary depending on the specific type of bacterial infection and individual patient factors. It is particularly effective against anaerobic bacteria, which are organisms that do not require oxygen to grow. Some common anaerobic infections that Flagyl is used to treat include:

• Intra-abdominal infections
• Pelvic infections
• Lung abscesses
• Brain abscesses
• Bacterial vaginosis

Common Side Effects of Flagyl

What are the most common side effects experienced by patients taking Flagyl? While many patients tolerate Flagyl well, some may experience side effects. The most frequently reported side effects include:

1. Nausea and vomiting
2. Diarrhea
3. Loss of appetite
4. Metallic taste in the mouth
5. Headache
6. Dizziness
7. Dry mouth
8. Dark or reddish-brown urine

It’s important to note that not everyone experiences these side effects, and some patients may experience different or more severe side effects. If side effects persist or worsen, it’s crucial to consult with a healthcare provider.

Precautions and Warnings for Flagyl Use

What precautions should be taken when using Flagyl? There are several important considerations and warnings associated with Flagyl use:

• Alcohol interaction: Patients should avoid alcohol consumption while taking Flagyl and for at least three days after completing the course of treatment. Combining Flagyl with alcohol can cause severe nausea, vomiting, flushing, and rapid heartbeat.
• Pregnancy and breastfeeding: Flagyl should be used with caution during pregnancy and while breastfeeding. It’s essential to discuss the potential risks and benefits with a healthcare provider.
• Neurological effects: In rare cases, Flagyl can cause neurological side effects such as seizures or peripheral neuropathy. Patients with a history of neurological disorders should be closely monitored.
• Drug interactions: Flagyl can interact with various medications, including blood thinners, lithium, and certain seizure medications. It’s crucial to inform your healthcare provider of all medications you’re taking.
• Liver disease: Patients with liver disease may require dose adjustments, as Flagyl is primarily metabolized by the liver.

Flagyl Dosage and Administration

How is Flagyl typically administered? The dosage and duration of Flagyl treatment can vary depending on the type and severity of the infection being treated. Some common dosage regimens include:

• For most bacterial infections in adults: 500 mg orally every 8 hours for 7-10 days
• For trichomoniasis: 2 grams as a single dose, or 500 mg twice daily for 7 days
• For amebiasis: 500-750 mg three times daily for 5-10 days
• For Helicobacter pylori infections: 500 mg twice daily for 10-14 days, usually in combination with other medications

It’s crucial to complete the full course of antibiotics as prescribed, even if symptoms improve before the medication is finished. This helps prevent the development of antibiotic-resistant bacteria.

Comparing Flagyl to Other Antibiotics

How does Flagyl compare to other antibiotics in treating bacterial infections? Flagyl is unique among antibiotics due to its effectiveness against anaerobic bacteria and certain parasites. While it may not be the first-line treatment for all bacterial infections, it is often the preferred choice for specific conditions such as:

• Bacterial vaginosis
• Trichomoniasis
• Clostridioides difficile infections
• Certain intra-abdominal infections

Compared to broad-spectrum antibiotics like amoxicillin or ciprofloxacin, Flagyl has a more targeted action against anaerobic bacteria. This can be beneficial in reducing the risk of antibiotic resistance and minimizing disruption to the body’s normal bacterial flora.

However, Flagyl is not effective against aerobic bacteria, which are common causes of many infections. In some cases, Flagyl may be prescribed in combination with other antibiotics to provide coverage against both aerobic and anaerobic bacteria.

Patient Experiences with Flagyl

What do patients say about their experiences with Flagyl? Based on user reviews, patient experiences with Flagyl vary widely. Some common themes in positive reviews include:

• Effectiveness in clearing up infections quickly
• Relief from symptoms associated with bacterial vaginosis and trichomoniasis
• Successful treatment of dental infections and abscesses

Negative reviews often mention:

• Severe side effects, particularly gastrointestinal issues
• Metallic taste in the mouth affecting appetite
• Neurological side effects such as dizziness or headaches
• Difficulty completing the full course due to side effects

It’s important to remember that individual experiences can vary greatly, and what works well for one person may not be as effective or well-tolerated by another.

Managing Side Effects of Flagyl

How can patients manage the side effects of Flagyl? While some side effects may be unavoidable, there are strategies to help minimize discomfort:

• Take Flagyl with food to reduce nausea and stomach upset
• Stay well-hydrated to help combat the metallic taste and dry mouth
• Avoid alcohol completely during treatment and for several days after
• Use probiotics to help maintain healthy gut bacteria and reduce the risk of antibiotic-associated diarrhea
• If experiencing severe or persistent side effects, contact your healthcare provider for guidance

Flagyl and Antibiotic Resistance

What role does Flagyl play in the context of antibiotic resistance? Antibiotic resistance is a growing concern in healthcare, and Flagyl is not immune to this issue. While resistance to Flagyl is less common compared to some other antibiotics, it has been observed in certain bacteria, particularly Helicobacter pylori and some strains of Clostridioides difficile.

To help prevent the development of antibiotic resistance:

• Only use Flagyl when prescribed by a healthcare provider for a confirmed bacterial or parasitic infection
• Complete the full course of antibiotics as prescribed
• Do not save leftover antibiotics for future use or share them with others
• Practice good hygiene to prevent the spread of infections

Long-term Effects and Considerations

Are there any long-term effects or considerations to be aware of when using Flagyl? While Flagyl is generally considered safe for short-term use, there are some potential long-term considerations:

• Neurological effects: In rare cases, long-term use of Flagyl has been associated with peripheral neuropathy. This risk appears to increase with prolonged use or high doses.
• Gut microbiome impact: Like all antibiotics, Flagyl can disrupt the balance of bacteria in the gut. This may lead to short-term gastrointestinal issues and potentially contribute to longer-term changes in gut health.
• Cancer risk: Some studies have suggested a potential link between long-term metronidazole use and an increased risk of certain cancers in animal models. However, human studies have not conclusively demonstrated this risk.
• Fertility and reproductive health: While short-term use is not typically associated with fertility issues, the effects of long-term use on reproductive health are not well-studied.

It’s important to discuss any concerns about long-term use or repeated courses of Flagyl with a healthcare provider.

Alternatives to Flagyl

What are some alternatives to Flagyl for treating bacterial infections? The choice of antibiotic depends on the specific infection being treated, but some common alternatives to Flagyl include:

• Clindamycin: Often used for anaerobic infections and as an alternative for patients allergic to penicillin
• Tinidazole: Another nitroimidazole antibiotic, similar to Flagyl but often with a shorter treatment duration
• Vancomycin: Used for severe C. difficile infections and some other resistant bacterial infections
• Amoxicillin/clavulanic acid (Augmentin): A broad-spectrum antibiotic effective against many common bacterial infections
• Doxycycline: Used for a wide range of bacterial infections, including some anaerobic bacteria

The choice of antibiotic should always be made in consultation with a healthcare provider based on the specific infection, local resistance patterns, and individual patient factors.

Flagyl in Special Populations

How is Flagyl used in special populations such as children, elderly patients, or those with compromised immune systems? The use of Flagyl in these populations requires special considerations:

Children

Flagyl is approved for use in children for certain indications. Dosages are typically based on the child’s weight. It’s important to carefully follow pediatric dosing guidelines to ensure safety and efficacy.

Elderly Patients

Older adults may be more susceptible to side effects and may require dose adjustments, particularly if they have impaired kidney or liver function. Close monitoring is often necessary.

Immunocompromised Patients

Patients with weakened immune systems may be at higher risk for certain infections that Flagyl treats, such as C. difficile colitis. However, they may also be more susceptible to side effects and drug interactions.

Pregnant and Breastfeeding Women

Flagyl is generally considered safe during pregnancy, particularly after the first trimester. However, it should be used with caution and only when the potential benefits outweigh the risks. For breastfeeding mothers, short-term use is generally considered acceptable, but it’s recommended to wait 12-24 hours after the last dose before breastfeeding.

In all these special populations, the use of Flagyl should be carefully evaluated by a healthcare provider, weighing the potential benefits against the risks.

Future Developments and Research

What future developments or research are underway regarding Flagyl and its use in treating bacterial infections? While Flagyl has been in use for several decades, ongoing research continues to explore its potential applications and improve its use:

• Combination therapies: Researchers are investigating new combinations of Flagyl with other antibiotics to improve efficacy and reduce the risk of resistance.
• Targeted delivery systems: Studies are exploring novel drug delivery methods to enhance the effectiveness of Flagyl while minimizing side effects.
• Mechanisms of action: Ongoing research aims to better understand the precise mechanisms by which Flagyl works against different pathogens, potentially leading to more targeted treatments.
• Resistance patterns: Continuous monitoring of antibiotic resistance patterns helps inform treatment guidelines and preserve the effectiveness of Flagyl.
• New indications: Researchers are exploring the potential use of Flagyl in treating other conditions, including certain types of cancer and inflammatory bowel diseases.

As research progresses, our understanding of how to best use Flagyl and other antibiotics continues to evolve, potentially leading to more effective and safer treatment options for patients with bacterial infections.

Flagyl User Reviews for Bacterial Infection

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Flagyl
has an average rating of 5.9 out of 10 from a total of 212 reviews
for the
treatment of Bacterial Infection.
43% of reviewers reported a positive experience, while 32% reported a negative experience.

Filter by condition
All conditionsAmebiasisAspiration PneumoniaBacteremiaBacterial Infection (234)Balantidium coliBone infection (1)Clostridioides difficile Infection (6)Deep Neck InfectionDental Abscess (18)Dientamoeba fragilisDiverticulitis (83)DracunculiasisEndocarditisGiardiasis (4)Helicobacter Pylori Infection (12)Intraabdominal Infection (2)Joint InfectionMeningitisNongonococcal UrethritisPelvic Inflammatory Disease (2)Peritonitis (1)Pneumonia (1)Pseudomembranous ColitisSkin or Soft Tissue Infection (3)STD ProphylaxisSurgical Prophylaxis (1)Trichomoniasis (15)

Flagyl rating summary

5.9/10 average rating

212 ratings from 234 user reviews.

Compare all 1039 medications used in the treatment of Bacterial Infection.

Reviews for Flagyl

Frequently asked questions

• What are the most common skin conditions? (with photos)
• What happens if you drink alcohol with metronidazole?
• Does Flagyl treat UTI infections?
• Can Flagyl be used to treat diarrhea?

Are you taking this medicine?

• Add your review
• Learn more about Flagyl

More FAQ

• Does Flagyl make your urine dark?
• How long does it take for metronidazole to work?
• How long does it take metronidazole to leave your system?
• Can metronidazole cause a yeast infection?

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Bacterial Infection

• Antibiotic Resistance: The Top 10 List
• Antibiotic Shortages: A Serious Safety Concern
• Antibiotics Guide
• Can You Drink Alcohol With Antibiotics?
• Common Side Effects from Antibiotics, and Allergies and Reactions
• Middle Ear Infection FAQs (Acute Otitis Media)

Medicine.com guides (external)

• Bacterial Infection Guide

More about Flagyl (metronidazole)

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (390)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Generic availability
• Support group
• Drug class: amebicides
• Breastfeeding
• En español

Patient resources

• Drug Information
• Flagyl (Advanced Reading)

Other brands

Flagyl ER

Professional resources

• Prescribing Information

Other formulations

• Flagyl I. V.
• Flagyl 375 Capsules

Related treatment guides

• Bacterial Infection
• Amebiasis
• Bacteremia
• Aspiration Pneumonia

Flagyl Reviews & Ratings – Drugs.com

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Save

Flagyl
has an average rating of 6.2 out of 10 from a total of 383 reviews
on Drugs.com.
48% of reviewers reported a positive experience, while 28% reported a negative experience.

Reviews for Flagyl

Frequently asked questions

• What are the most common skin conditions? (with photos)
• What happens if you drink alcohol with metronidazole?
• Does Flagyl treat UTI infections?
• Can Flagyl be used to treat diarrhea?

Are you taking this medicine?

• Add your review
• Learn more about Flagyl

More FAQ

• Does Flagyl make your urine dark?
• How long does it take for metronidazole to work?
• How long does it take metronidazole to leave your system?
• Can metronidazole cause a yeast infection?

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

More about Flagyl (metronidazole)

• Check interactions
• Compare alternatives
• Pricing & coupons
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Generic availability
• Support group
• Drug class: amebicides
• Breastfeeding
• En español

Patient resources

• Drug Information
• Flagyl (Advanced Reading)

Other brands

Flagyl ER

Professional resources

• Prescribing Information

Other formulations

• Flagyl I.V.
• Flagyl 375 Capsules

Related treatment guides

• Bacterial Infection
• Amebiasis
• Bacteremia
• Aspiration Pneumonia

film-coated tablets, vaginal suppositories, 500mg, 250mg

Date of approval: 31. 07.1999

Contents

• Active substance
• ATX
• Pharmacological group
• Nosological classification (ICD-10)
• Composition and form of release
• pharmachologic effect
• Pharmacokinetics
• Indications
• Contraindications
• Use during pregnancy and lactation
• Dosage and administration
• Side effects
• Interaction
• Precautionary measures
• Storage conditions
• Best before date
• Order in Moscow pharmacies
• Reviews

Active ingredient

Metronidazole* (Metronidazole*)

ATX

J01XD01 Metronidazole

Pharmacological group

Other synthetic antibacterial agents

Nosological classification (ICD-10)

ICD-10 code list

• A06 Amoebiasis
  (solution for infusion)
• A07 Other protozoal intestinal diseases
  (vaginal suppositories)
• A07. 1 Giardiasis [giardiasis]
  (solution for infusion)
• A59 Trichomoniasis
  (solution for infusion)
• N76 Other inflammatory diseases of the vagina and vulva
  (solution for infusion)
• Z100* CLASS XXII Surgical practice
  (solution for infusion)

Composition and formulation

1 coated tablet contains metronidazole 250 mg; 10 pcs in a blister, 2 blisters in a cardboard box.

1 vaginal suppository 500 mg; in a blister 5 pcs., in a cardboard box 2 blisters.

100 ml 0.5% IV solution – 500 mg; in bottles of 100 ml, in a cardboard box 25 pcs.

Pharmacological action

Pharmacological action –

antibacterial , antiprotozoal .

Pharmacokinetics

Rapidly and completely absorbed. T _1/2 – 8-10 hours, binding to plasma proteins does not exceed 10-20%. Easily penetrates into tissues (lungs, kidneys, liver, skin, bile, cerebrospinal fluid, saliva, seminal fluid, vaginal secretion), into mother’s milk, overcomes the placental barrier. It is excreted by 40-70% (about 20% in unchanged form) through the kidneys.

Indications

Amoebiasis, urogenital trichomoniasis, nonspecific vaginitis, giardiasis (intestinal and hepatic), surgical infections caused by anaerobes.

Contraindications

Hypersensitivity.

Use during pregnancy and lactation

Use with caution during pregnancy, stop breastfeeding during lactation.

Dosage and Administration

Information for healthcare professionals only.
Are you a healthcare professional?

For amoebiasis, by mouth, 1.5 g/day in 3 doses (adults) and 30–40 mg/kg/day also in 3 doses (children) for 7 days. With giardiasis – adults – 750-1000 mg / day, children 2-5 years old – 250 mg / day, children 5-10 years old – 375 mg / day, 10-15 years old – 500 mg / day for 5 days. With trichomoniasis in women (urethritis and vaginitis) – once at a dose of 2 g or as a course of treatment for 10 days – 250 mg 2 times a day and 1 vaginal suppository per day. With trichomonas urethritis in men – once at a dose of 2 g or as a course of treatment for 10 days, 250 mg 2 times a day. With nonspecific vaginitis – 500 mg 2 times a day for a week. For anaerobic infections, adults – 1-1.5 g / day, children – at the rate of 20-30 mg / kg / day. In / in the introduction is shown only if it is impossible to take it in another way or in severe forms of the disease. 100 ml (500 mg) of the drug is administered over 30–60 minutes.

Side effects

Nausea, metallic taste in the mouth, anorexia, epigastric pain, vomiting, diarrhoea, headache, dizziness, allergic reactions (urticaria, itching), leukopenia, peripheral neuropathies; urine staining.

Interactions

Information for healthcare professionals only.
Are you a healthcare professional?

Compatible with sulfonamides and antibiotics. The combination with disulfiram, anticoagulants of indirect action and non-depolarizing muscle relaxants is undesirable. Incompatible with alcoholic beverages. Increases the concentration of lithium in plasma.

Precautions

Long-term treatment is preferably carried out under the control of the blood count. A false-positive Nelson test is possible because treponema is immobilized. Combine with caution with indirect anticoagulants, non-depolarizing muscle relaxants. At the time of treatment, the use of alcoholic beverages should be excluded.

Storage conditions

solution for infusion 0.5% vial —
In a place protected from light, at a temperature not exceeding 25 ° C.
vaginal suppositories 500 mg blister pack —
At a temperature not higher than 25 °C.

Keep out of reach of children.

Shelf life

solution for infusion 0.5% vial – 3 years.
vaginal suppositories 500 mg blister pack – 4 years.

Do not use after the expiry date which is stated on the package.

Update date: 06/20/2023

The information provided on the prices of drugs is not an offer to sell or buy goods.

The information is intended solely for comparing prices in stationary pharmacies operating in
in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 No. 61-FZ.

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