What are the primary uses of griseofulvin oral medication. How should griseofulvin be taken for optimal absorption. What are the common side effects of griseofulvin. How long does griseofulvin treatment typically last. What precautions should be taken when using griseofulvin.

Understanding Griseofulvin: An Antifungal Medication

Griseofulvin is an oral antifungal medication used to treat various fungal infections that do not respond to topical treatments. This powerful drug works by inhibiting the growth of fungi, providing relief from persistent infections of the skin, hair, and nails.

How Does Griseofulvin Work?

Griseofulvin’s mechanism of action involves interfering with the fungal cell division process. By disrupting the microtubules within fungal cells, it prevents their growth and replication. This targeted approach makes griseofulvin effective against dermatophytes, the fungi responsible for many common skin and nail infections.

Primary Uses of Griseofulvin in Fungal Infection Treatment

Griseofulvin is prescribed for a range of fungal infections that have proven resistant to topical treatments. Its primary uses include:

• Treating stubborn fungal infections of the skin
• Addressing persistent fungal infections of the hair and scalp
• Managing recalcitrant fungal nail infections

These infections often manifest with symptoms such as itching, redness, peeling or scaly skin, and discolored nails. By targeting the underlying fungal cause, griseofulvin helps alleviate these symptoms and restore healthy skin and nail appearance.

Can griseofulvin treat all types of infections?

No, griseofulvin is specifically designed to combat fungal infections. It is not effective against bacterial infections or yeast-related conditions. For these types of infections, alternative treatments would be necessary.

Proper Administration and Dosage of Griseofulvin

To ensure optimal effectiveness, griseofulvin should be taken as prescribed by a healthcare professional. The typical administration guidelines include:

1. Taking the medication orally with or after a meal containing moderate fat content
2. Following a consistent dosing schedule to maintain constant medication levels in the body
3. Continuing the full course of treatment, even if symptoms improve early

How does food affect griseofulvin absorption?

Griseofulvin absorption is enhanced when taken with a meal containing moderate amounts of fat. This dietary consideration helps improve the bioavailability of the medication, allowing for better efficacy in treating fungal infections.

Dosage Considerations and Treatment Duration

The dosage of griseofulvin is determined based on several factors, including:

• The specific type of fungal infection being treated
• The patient’s body weight (especially important for pediatric dosing)
• The individual’s response to therapy

Treatment duration can vary significantly depending on the infection site and severity. For instance:

• Scalp infections may require several weeks to months of treatment
• Foot and body infections typically need a similar timeframe
• Nail infections often demand the longest treatment period, potentially lasting a year or more

Why is it crucial to complete the full course of griseofulvin treatment?

Completing the full prescribed course of griseofulvin is essential to ensure the complete eradication of the fungal infection. Premature discontinuation may allow residual fungi to regrow, potentially leading to a relapse of the infection and necessitating additional treatment.

Potential Side Effects and Adverse Reactions

While griseofulvin is generally well-tolerated, it can cause various side effects. Common side effects may include:

• Headache
• Nausea and vomiting
• Diarrhea and stomach upset
• Fatigue and dizziness
• Sleep disturbances

More serious side effects, though less common, can occur and require immediate medical attention. These may include:

• Numbness or tingling in extremities
• Mental or mood changes
• Hearing alterations
• Facial rash (particularly a butterfly-shaped rash around the nose and cheeks)
• Joint or muscle pain
• Signs of liver or kidney problems

Is griseofulvin associated with an increased risk of infections?

Prolonged use of griseofulvin may increase the risk of developing oral thrush or vaginal yeast infections. Patients should be vigilant for symptoms such as white patches in the mouth or changes in vaginal discharge, and report these to their healthcare provider promptly.

Important Precautions and Interactions

Before starting griseofulvin treatment, it’s crucial to inform your healthcare provider about:

• Any known allergies, especially to griseofulvin or its components
• Pre-existing medical conditions, particularly porphyria, liver disease, or lupus
• Current medications, including over-the-counter drugs and supplements
• Pregnancy status or plans to become pregnant

Griseofulvin may interact with various substances and conditions, necessitating certain precautions:

1. Avoid alcohol consumption during treatment, as it can cause rapid heartbeat and skin flushing
2. Exercise caution when exposed to sunlight, as griseofulvin may increase sun sensitivity
3. Be aware of potential drowsiness or reduced alertness, which may affect activities like driving

How does griseofulvin affect pregnancy and fertility?

Griseofulvin can potentially harm an unborn baby and should be avoided during pregnancy. Additionally, it may interfere with the effectiveness of hormonal contraceptives. Women of childbearing age should use alternative contraception methods during treatment and for at least one month after completing the course.

Monitoring and Follow-up During Griseofulvin Treatment

Regular monitoring is essential during griseofulvin therapy to ensure its effectiveness and detect any potential complications. This typically involves:

• Periodic blood tests to assess liver function
• Regular skin and nail examinations to track infection improvement
• Monitoring for any new or worsening side effects

Patients should maintain open communication with their healthcare provider throughout the treatment course, reporting any concerns or unexpected symptoms promptly.

When should improvement be expected during griseofulvin treatment?

The timeline for improvement can vary depending on the type and severity of the fungal infection. While some patients may notice initial improvements within a few weeks, complete resolution of symptoms, particularly for nail infections, may take several months or longer. Patience and adherence to the prescribed regimen are crucial for optimal outcomes.

Alternative Treatments and Combination Therapies

While griseofulvin is effective for many fungal infections, there may be instances where alternative or complementary treatments are considered. These could include:

• Topical antifungal medications for milder infections
• Newer oral antifungal drugs like terbinafine or itraconazole
• Combination therapies using both oral and topical treatments

The choice of treatment depends on factors such as the specific fungal species involved, the extent of the infection, and individual patient characteristics.

Can griseofulvin be combined with other antifungal treatments?

In some cases, healthcare providers may recommend combining griseofulvin with topical antifungal treatments to enhance efficacy. However, this approach should only be undertaken under professional guidance to avoid potential drug interactions or adverse effects.

Griseofulvin remains a valuable tool in the treatment of persistent fungal infections. Its ability to target a wide range of dermatophytes makes it particularly useful for infections that have not responded to other treatments. However, like all medications, it requires careful administration and monitoring to ensure optimal results and minimize potential risks.

As research in antifungal therapies continues to advance, new treatments and combination approaches may emerge. Patients dealing with stubborn fungal infections should work closely with their healthcare providers to determine the most appropriate treatment plan, considering factors such as infection type, severity, and individual health status.

The journey to clear, healthy skin and nails may be lengthy, but with proper use of medications like griseofulvin and adherence to medical advice, many patients can successfully overcome persistent fungal infections. Regular follow-ups and open communication with healthcare providers are key to navigating the treatment process and achieving the best possible outcomes.

Griseofulvin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used to treat fungal infections of the skin, hair, and nails that do not respond to creams/lotions. Clearing such infections will get rid of symptoms such as itching, red/peeling/scaly skin, and discolored nails. This medication works by stopping the growth of fungi. It does not treat infections due to bacteria or yeast.

How to use Griseofulvin 250 Mg Tablet

Take this medication by mouth as directed by your doctor. For the best absorption, it is best taken with or after a meal containing a moderate amount of fat. Talk to your doctor or pharmacist about specific dietary instructions, especially if you are on a low-fat diet.

The dosage is based on your medical condition and response to therapy. In children, dosage is also based on weight. The length of treatment depends on the type of infection you have. It may take several weeks to months to complete treatment for infections of the scalp, feet, and body. Nail infections may require several months to a year or longer to treat.

Antifungal medications work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.

Continue to take this medication for the full prescribed length of treatment even if symptoms improve after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition lasts or gets worse.

Side Effects

Headache, nausea, vomiting, diarrhea, stomach upset, tiredness, dizziness, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling of the hands/feet, mental/mood changes (such as confusion, trouble doing normal activities), hearing changes, butterfly-shaped facial rash (around the nose and cheeks), joint/muscle pain, signs of liver disease (such as nausea/vomiting that doesn’t stop, stomach/abdominal pain, yellowing eyes/skin, dark urine), signs of kidney problems (such as change in the amount of urine, frothy urine), signs of infection (such as sore throat that doesn’t go away, fever).

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking griseofulvin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain blood disorder (porphyria), liver disease, lupus.

This drug may make you dizzy or less alert. Alcohol or marijuana (cannabis) can make you more dizzy or much less alert. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages while you are taking this drug unless your doctor gives permission. Drinking alcohol during treatment with this drug could result in a fast heartbeat and flushing of the skin. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using griseofulvin. Griseofulvin may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 1 month after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Drug Interactions section.)

The effects of this drug on human sperm are unknown. However, based on animal cell studies, the manufacturer recommends waiting for a period of time after completing griseofulvin treatment before trying to father a child. Discuss the risks and benefits with your doctor, and ask how long to wait after your last dose before trying to father a child.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: barbiturates (such as phenobarbital), warfarin.

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Does Griseofulvin 250 Mg Tablet interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Lab and/or medical tests (such as kidney/liver function, complete blood count) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Ask your doctor or pharmacist about ways to control the infection and to prevent re-infection. Fungus spreads easily in warm, moist areas. Follow good hygiene (for example wash and dry the infected area completely, and do not share articles of clothing or objects that come in contact with the infected area).

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Griseofulvin: MedlinePlus Drug Information

pronounced as (gri see oh ful’ vin)

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Griseofulvin is used to treat skin infections such as jock itch, athlete’s foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Griseofulvin comes as a tablet, capsule, and liquid to take by mouth. It is usually taken once a day or can be taken two to four times a day. Although your symptoms may get better in a few days, you will have to take griseofulvin for a long time before the infection is completely gone. It is usually taken for 2 to 4 weeks for skin infections, 4 to 6 weeks for hair and scalp infections, 4 to 8 weeks for foot infections, 3 to 4 months for fingernail infections, and at least 6 months for toenail infections. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take griseofulvin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

Continue to take griseofulvin even if you feel well. Do not stop taking griseofulvin without talking to your doctor.

Before taking griseofulvin,

• tell your doctor and pharmacist if you are allergic to griseofulvin, or any other medications.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants (‘blood thinners’) such as warfarin (Coumadin), oral contraceptives, cyclosporine (Neoral, Sandimmune), phenobarbital (Luminal), and vitamins.
• tell your doctor if you have or have ever had liver disease, porphyria, lupus, or a history of alcohol abuse.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking griseofulvin, call your doctor.
• tell your doctor if you drink alcohol.
• you should plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Griseofulvin may make your skin sensitive to sunlight.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Griseofulvin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• upset stomach
• vomiting
• diarrhea or loose stools
• thirst
• fatigue
• dizziness
• faintness

If you experience any of the following symptoms, call your doctor immediately:

• fever
• sore throat
• skin rash
• mouth soreness or irritation

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep the liquid away from light. Do not freeze.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www. poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

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Last Revised – 06/15/2017

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Griseofulvin tablets 125mg №20 at a low price in Omsk, instructions for use, composition, analogues active substance

Griseofulvin

Manufacturer

Biosynthesis PAO

Instructions for use – Griseofulvin

Manufacturer

Biosintez, Russia

Composition

Active ingredient:

griseofulvin 125 mg.

Pharmacological action

Griseofulvin is an antifungal antibiotic.

Has a fungistatic effect.

Active against dermatophytes of the genera Trichophyton, Microsporum, Epidermophyton.

Inhibits cell division of fungal cells in metaphase by disrupting the structure of the mitotic spindle.

Griseofulvin accumulates to varying degrees in keratin precursor cells of the skin, hair and nails, making keratin resistant to fungal invasion.

As the infected keratin is separated, it is replaced by healthy tissue.

Indications

Mycoses of the skin, hair and nails, etc.

Contraindications

Hypersensitivity, systemic lupus erythematosus, liver and kidney diseases.

Side effects

From the side of the central nervous system: headache, dizziness, disorientation, unusual fatigue or weakness, insomnia, peripheral neuropathy, impaired coordination of movements, paresthesia of the extremities, confusion.

From the gastrointestinal tract: nausea, vomiting, diarrhea, gastralgia, candidal stomatitis, hepatitis.

From the side of hematopoiesis: granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: urticaria, skin rash, pruritus, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme exudative, Lyell’s syndrome.

Interaction

Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, anticoagulants of indirect action (due to the induction of microsomal liver enzymes).

Barbiturates and primidone reduce antifungal activity.

How to take, course of administration and dosage

Orally, during or after meals with vegetable oil.

In case of microsporia, children are prescribed at the rate of 21-22 mg per 1 kg of the patient’s body weight per day, adults – from 500 to 1000 mg (8 tablets per day).

The drug is taken daily until the first negative fungal test, then at the same dose every other day for 2 weeks and then 2 times a week for 2 weeks.

With trichophytosis (superficial and infiltrative-suppurative forms) and favus for children – at the rate of 18 mg/kg of body weight according to the same scheme as for microsporia.

For onychomycosis, trichophytosis and favus of the scalp, the daily dose for adults weighing up to 50 kg is 625 mg (5 tablets). The maximum daily dose is 1 g (8 tablets).

The daily dose in children and adolescents is 16 mg/kg body weight.

In case of onychomycosis, the drug is prescribed daily for the first month, every other day for the second month, then 2 times a week in the same daily dose until the nails grow completely.

The total duration of treatment is at least 8 months.

Special instructions

Treatment with Griseofulvin is carried out under the control of the morphological composition of the blood (1 time in 10-15 days).

Release form

Tablets

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf life

3 years 6 months

Active ingredient

Griseofulvin

Pharmacy conditions

Prescription

Formulation

tablets

Prescription

Prescription children, Prescription adults, Children over 3 years

Indications

Scalp fungus , Skin fungus, Fungus, Nail fungus

Barcode and weight

Barcode: 4602884000204

Weight: 0. 110 kg.

Griseofulvin tab 125mg №20 – Gorpharma

Instructions for use Griseofulvin 125mg 20 pcs. tablets
Composition and formulation
Description of dosage form
Pharmacological action
Pharmacokinetics
Pharmacodynamics
Indications for use
Contraindications for use
Use in pregnancy and children
Side effects
Drug interactions
Dosage
Overdose
Precautions
Composition and Presentation
Tablets – 1 tab.:

Active ingredient: Griseofulvin – 125 mg;
Excipients: lactose monohydrate (milk sugar) – 25.56 mg; calcium stearate – 1.80 mg; povidone (polyvinylpirollidone low molecular weight medical 12600 ± 2700, K-17) – 3.78 mg; potato starch – 23.86 mg.
10 tablets in a blister pack made of polyvinyl chloride film and printed lacquered aluminum foil.

2 blister packs with instructions for use of the drug in a pack of cardboard.

Description of dosage form
Tablets white or white with a yellowish tinge, flat-cylindrical, with a bevel.

Pharmacological action
Antifungal agent.

Pharmacokinetics
Absorption – high: microcrystalline form – 25-70%, ultramicrocrystalline form – almost 100%. Eating fatty foods enhances absorption. The time to reach the maximum concentration of the drug in plasma after oral administration is 4-5 hours, the maximum concentration of the drug in plasma is 0.5-5 mg / l. Communication with plasma proteins – 80%.

Selectively accumulates in the stratum corneum and its appendages, as well as in the liver, adipose tissue, and skeletal muscles. A small amount is distributed in body fluids and tissues. Penetrates through the placenta.

Metabolized in the liver with the formation of inactive metabolites (6-methyl-griseofulvin and glucuronide derivative).

The half-life of the drug is 24 hours.

Excreted by the kidneys (including 1% unchanged) and through the intestines (36% unchanged).

Pharmacodynamics
Antifungal antibiotic, effective against fungi of the genus Trichophyton, Microsporum, Epydermophyton Achorionum; causes disruption of the structure of the mitotic spindle and synthesis of the cell wall in chitin-containing fungi, inhibits the division of fungal cells in the metaphase and protein synthesis due to disruption of communication with matrix ribonucleic acid. It accumulates in the cells of the skin, hair and nails, which are precursors of keratin, making keratin resistant to fungal invasion. As the infected keratin is separated, it is replaced by healthy tissue.

Indications for use
Mycosis of the skin, hair and nails (microsporia, trichophytosis, favus, onychomycosis, epidermophytosis groin).

Contraindications for use
Hypersensitivity to griseofulvin or to any component of the drug, porphyria, systemic lupus erythematosus, lupus-like syndrome, systemic blood diseases, leukopenia, organic diseases of the liver and kidneys, liver failure, malignant neoplasms, pregnancy, breastfeeding, children age up to 3 years.

Use in pregnancy and children
The drug is contraindicated during pregnancy, as Griseofulvin crosses the placenta.

Breast-feeding should be discontinued during treatment.

Side effects
From the side of the nervous system: headache, dizziness, weakness, fatigue, insomnia, peripheral neuropathy, impaired coordination of movements, disorientation, paresthesia of the extremities, confusion.

From the digestive system: nausea, vomiting, diarrhea, gastralgia, candidal stomatitis, hepatitis.

From the side of hematopoiesis: granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: urticaria, skin rash, pruritus, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme exudative, toxic epidermal necrolysis (Lyell’s syndrome).

With widespread rashes, desensitizing therapy is carried out. If the rash continues to grow, griseofulvin should be discontinued for 3-4 days. After the disappearance of the rashes, the antibiotic is prescribed again, but starts with 1/2 tablet per day, and then the dose is gradually increased to the original one within 3-4 days.

Drug interaction
Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, indirect anticoagulants due to the induction of microsomal liver enzymes.

Barbiturates and primidone reduce antifungal activity.

Dosage
By mouth, during or after meals, in one or more doses.

Adults – at a daily dose of 500 mg. In severe mycoses, the dose is increased.

Children – at a daily dose of 10 mg/kg.

The duration of treatment for severe mycoses is up to 12 months. The course of treatment for damage to the skin of the body – 2-4 weeks, the scalp – 4-6 weeks, feet – 4-8 weeks, fingers – at least 4 months, toes – at least 6 months. The highest daily dose is 1 g.

Overdose
In case of overdose, symptomatic therapy and therapy to maintain vital organs and systems is recommended.

Precautions
Due to the negative impact on reproductive function (both in men and women), it is necessary to use effective non-hormonal methods of contraception.

Systemic griseofulvin is not used to treat mild infections for which topical antifungals alone are sufficient.

Influence on the ability to drive vehicles and control mechanisms

The potential for the development of such side effects as dizziness, drowsiness, impaired coordination of movements, disorientation, confusion should be taken into account.