What are the primary uses of Griseofulvin oral medication. How should Griseofulvin be taken for optimal absorption. What are the common and serious side effects of Griseofulvin. How does Griseofulvin interact with other medications and substances.

Understanding Griseofulvin: An Antifungal Powerhouse

Griseofulvin is a potent antifungal medication used to treat various fungal infections that affect the skin, hair, and nails. This oral medication is particularly effective against infections that have not responded to topical treatments, making it a valuable tool in the fight against persistent fungal issues.

How Does Griseofulvin Work?

Griseofulvin works by inhibiting the growth of fungi. It does this by interfering with the microtubules of fungal cells, which are essential for cell division. By disrupting this process, griseofulvin effectively stops the spread of the fungal infection, allowing the body’s immune system to eliminate the remaining fungi.

It’s important to note that griseofulvin is specifically designed to target fungal infections. It does not have any effect on bacterial or yeast infections, which require different types of treatment.

The Versatility of Griseofulvin in Treating Fungal Infections

Griseofulvin’s versatility makes it a go-to treatment for a wide range of fungal infections. But what specific conditions can it treat?

• Tinea capitis (scalp ringworm)
• Tinea corporis (body ringworm)
• Tinea pedis (athlete’s foot)
• Tinea unguium (fungal nail infections)
• Tinea barbae (beard ringworm)

Each of these conditions can be stubborn and resistant to topical treatments, which is where griseofulvin shines. Its systemic action allows it to reach areas that topical treatments cannot, making it particularly effective for deep-seated or widespread fungal infections.

Duration of Treatment

The duration of treatment with griseofulvin varies depending on the type and severity of the infection. For infections of the scalp, feet, and body, treatment may last several weeks to months. Nail infections, being particularly stubborn, may require several months to a year or even longer to treat effectively.

Proper Administration of Griseofulvin for Maximum Efficacy

To ensure the best results from griseofulvin treatment, it’s crucial to take the medication correctly. How should griseofulvin be taken for optimal absorption?

Griseofulvin should be taken orally, as directed by your healthcare provider. For best absorption, it’s recommended to take the medication with or after a meal containing a moderate amount of fat. This is because griseofulvin is lipophilic, meaning it dissolves in fats, which aids in its absorption by the body.

Dosage Considerations

The dosage of griseofulvin is determined based on several factors:

• The patient’s medical condition
• Response to therapy
• Body weight (especially important for children)

It’s essential to maintain a constant level of the medication in your body for it to work effectively. This means taking griseofulvin at evenly spaced intervals throughout the day, as prescribed by your doctor.

Importance of Completing the Full Course

Why is it crucial to complete the full course of griseofulvin treatment? Even if symptoms improve after a few days, it’s important to continue taking the medication for the entire prescribed duration. Stopping the treatment prematurely may allow the fungus to continue growing, potentially leading to a relapse of the infection.

Navigating the Side Effects of Griseofulvin

Like all medications, griseofulvin can cause side effects. While many people tolerate the medication well, it’s important to be aware of potential adverse reactions. What are the common and serious side effects of griseofulvin?

Common Side Effects

Some of the more common side effects of griseofulvin include:

• Headache
• Nausea
• Vomiting
• Diarrhea
• Stomach upset
• Tiredness
• Dizziness
• Trouble sleeping

These side effects are usually mild and often resolve on their own as your body adjusts to the medication. However, if these effects persist or worsen, it’s important to consult your healthcare provider.

Serious Side Effects

While less common, some serious side effects may occur with griseofulvin use. These require immediate medical attention and include:

• Numbness or tingling in hands or feet
• Mental or mood changes (confusion, difficulty with normal activities)
• Hearing changes
• Butterfly-shaped facial rash
• Joint or muscle pain
• Signs of liver disease (persistent nausea/vomiting, abdominal pain, yellowing of eyes/skin, dark urine)
• Signs of kidney problems (changes in urine amount, frothy urine)
• Signs of infection (persistent sore throat, fever)

In rare cases, prolonged use of griseofulvin may lead to oral thrush or vaginal yeast infections. If you notice white patches in your mouth or changes in vaginal discharge, contact your healthcare provider.

Griseofulvin Interactions: What You Need to Know

Understanding how griseofulvin interacts with other medications and substances is crucial for safe and effective treatment. How does griseofulvin interact with other medications and substances?

Drug Interactions

Griseofulvin can interact with several medications, potentially affecting their efficacy or increasing the risk of side effects. Some notable interactions include:

• Oral contraceptives: Griseofulvin may reduce the effectiveness of birth control pills
• Warfarin: Griseofulvin may decrease the anticoagulant effect of warfarin
• Phenobarbital: This medication may decrease the effectiveness of griseofulvin
• Cyclosporine: Griseofulvin may reduce the blood levels of cyclosporine

Always inform your healthcare provider about all medications you’re taking, including over-the-counter drugs and supplements, to avoid potential interactions.

Alcohol Interaction

Griseofulvin can interact with alcohol, potentially leading to unpleasant side effects. What happens if you consume alcohol while taking griseofulvin?

Drinking alcohol while on griseofulvin can result in a rapid heartbeat and flushing of the skin, similar to the effects of disulfiram (a medication used to treat alcohol dependence). It’s generally recommended to avoid alcohol consumption during griseofulvin treatment unless your doctor explicitly permits it.

Precautions and Special Considerations for Griseofulvin Use

While griseofulvin is generally safe when used as directed, there are several precautions and special considerations to keep in mind. What precautions should be taken when using griseofulvin?

Medical History Considerations

Before starting griseofulvin treatment, it’s important to inform your healthcare provider about your complete medical history, especially if you have:

• Porphyria (a blood disorder)
• Liver disease
• Lupus
• Any allergies, particularly to medications

These conditions may affect how your body processes griseofulvin or increase the risk of certain side effects.

Pregnancy and Breastfeeding

Griseofulvin can potentially harm an unborn baby. If you’re pregnant or planning to become pregnant, it’s crucial to discuss this with your doctor before starting griseofulvin treatment. Alternative treatments may be recommended in such cases.

The safety of griseofulvin during breastfeeding is not well established. If you’re breastfeeding, consult with your healthcare provider to weigh the potential risks and benefits.

Sun Sensitivity

Griseofulvin can increase your skin’s sensitivity to sunlight. How can you protect yourself from sun-related side effects while taking griseofulvin?

• Limit sun exposure, especially during peak hours
• Avoid tanning beds and sunlamps
• Use broad-spectrum sunscreen with a high SPF
• Wear protective clothing when outdoors

If you notice any unusual skin reactions or severe sunburn while on griseofulvin, inform your healthcare provider promptly.

Monitoring and Follow-up During Griseofulvin Treatment

Regular monitoring and follow-up are essential parts of griseofulvin treatment. Why is ongoing medical supervision important during griseofulvin therapy?

Your healthcare provider will likely schedule periodic check-ups to monitor your progress and check for any potential side effects. These appointments may include:

• Physical examinations to assess the improvement of the fungal infection
• Blood tests to check liver function
• Discussions about any side effects you may be experiencing

These check-ups allow your doctor to adjust your treatment if necessary and ensure that the medication is working effectively without causing undue harm.

When to Seek Immediate Medical Attention

While most side effects of griseofulvin are mild, some situations require immediate medical attention. Seek emergency care if you experience:

• Signs of a severe allergic reaction (rash, itching/swelling, severe dizziness, trouble breathing)
• Severe or persistent side effects that significantly impact your quality of life
• Any symptoms that concern you or seem unusual

Remember, your healthcare provider is your best resource for addressing concerns or questions about your griseofulvin treatment.

Alternative Treatments and Complementary Approaches

While griseofulvin is a highly effective treatment for many fungal infections, it’s not the only option available. What alternative treatments might be considered for fungal infections?

Other Antifungal Medications

Depending on the specific fungal infection and individual patient factors, other antifungal medications might be prescribed, such as:

• Terbinafine
• Itraconazole
• Fluconazole

These medications work through different mechanisms and may be more suitable in certain cases.

Topical Treatments

For less severe or localized fungal infections, topical treatments may be sufficient. These can include:

• Antifungal creams or ointments
• Medicated shampoos
• Antifungal nail lacquers

These treatments are often used in combination with oral medications for more comprehensive treatment.

Complementary Approaches

While not a substitute for medical treatment, some complementary approaches may support overall health and potentially aid in managing fungal infections:

• Maintaining good hygiene practices
• Keeping affected areas clean and dry
• Wearing breathable fabrics
• Managing underlying health conditions that may increase susceptibility to fungal infections

It’s important to discuss any complementary approaches with your healthcare provider to ensure they don’t interfere with your prescribed treatment.

In conclusion, griseofulvin remains a valuable tool in the treatment of various fungal infections. Its systemic action makes it particularly effective against stubborn infections that don’t respond to topical treatments. However, like all medications, it requires careful administration and monitoring to ensure safe and effective use. By understanding how griseofulvin works, its potential side effects, and important precautions, patients can make informed decisions about their treatment in consultation with their healthcare providers. Remember, the key to successful treatment lies in adherence to prescribed regimens and open communication with your medical team.

Griseofulvin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used to treat fungal infections of the skin, hair, and nails that do not respond to creams/lotions. Clearing such infections will get rid of symptoms such as itching, red/peeling/scaly skin, and discolored nails. This medication works by stopping the growth of fungi. It does not treat infections due to bacteria or yeast.

How to use Griseofulvin 250 Mg Tablet

Take this medication by mouth as directed by your doctor. For the best absorption, it is best taken with or after a meal containing a moderate amount of fat. Talk to your doctor or pharmacist about specific dietary instructions, especially if you are on a low-fat diet.

The dosage is based on your medical condition and response to therapy. In children, dosage is also based on weight. The length of treatment depends on the type of infection you have. It may take several weeks to months to complete treatment for infections of the scalp, feet, and body. Nail infections may require several months to a year or longer to treat.

Antifungal medications work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.

Continue to take this medication for the full prescribed length of treatment even if symptoms improve after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition lasts or gets worse.

Side Effects

Headache, nausea, vomiting, diarrhea, stomach upset, tiredness, dizziness, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling of the hands/feet, mental/mood changes (such as confusion, trouble doing normal activities), hearing changes, butterfly-shaped facial rash (around the nose and cheeks), joint/muscle pain, signs of liver disease (such as nausea/vomiting that doesn’t stop, stomach/abdominal pain, yellowing eyes/skin, dark urine), signs of kidney problems (such as change in the amount of urine, frothy urine), signs of infection (such as sore throat that doesn’t go away, fever).

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking griseofulvin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain blood disorder (porphyria), liver disease, lupus.

This drug may make you dizzy or less alert. Alcohol or marijuana (cannabis) can make you more dizzy or much less alert. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages while you are taking this drug unless your doctor gives permission. Drinking alcohol during treatment with this drug could result in a fast heartbeat and flushing of the skin. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using griseofulvin. Griseofulvin may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 1 month after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Drug Interactions section.)

The effects of this drug on human sperm are unknown. However, based on animal cell studies, the manufacturer recommends waiting for a period of time after completing griseofulvin treatment before trying to father a child. Discuss the risks and benefits with your doctor, and ask how long to wait after your last dose before trying to father a child.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: barbiturates (such as phenobarbital), warfarin.

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Does Griseofulvin 250 Mg Tablet interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Lab and/or medical tests (such as kidney/liver function, complete blood count) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Ask your doctor or pharmacist about ways to control the infection and to prevent re-infection. Fungus spreads easily in warm, moist areas. Follow good hygiene (for example wash and dry the infected area completely, and do not share articles of clothing or objects that come in contact with the infected area).

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Griseofulvin: MedlinePlus Drug Information

pronounced as (gri see oh ful’ vin)

To use the sharing features on this page, please enable JavaScript.

Griseofulvin is used to treat skin infections such as jock itch, athlete’s foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Griseofulvin comes as a tablet, capsule, and liquid to take by mouth. It is usually taken once a day or can be taken two to four times a day. Although your symptoms may get better in a few days, you will have to take griseofulvin for a long time before the infection is completely gone. It is usually taken for 2 to 4 weeks for skin infections, 4 to 6 weeks for hair and scalp infections, 4 to 8 weeks for foot infections, 3 to 4 months for fingernail infections, and at least 6 months for toenail infections. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take griseofulvin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

Continue to take griseofulvin even if you feel well. Do not stop taking griseofulvin without talking to your doctor.

Before taking griseofulvin,

• tell your doctor and pharmacist if you are allergic to griseofulvin, or any other medications.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants (‘blood thinners’) such as warfarin (Coumadin), oral contraceptives, cyclosporine (Neoral, Sandimmune), phenobarbital (Luminal), and vitamins.
• tell your doctor if you have or have ever had liver disease, porphyria, lupus, or a history of alcohol abuse.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking griseofulvin, call your doctor.
• tell your doctor if you drink alcohol.
• you should plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Griseofulvin may make your skin sensitive to sunlight.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Griseofulvin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• upset stomach
• vomiting
• diarrhea or loose stools
• thirst
• fatigue
• dizziness
• faintness

If you experience any of the following symptoms, call your doctor immediately:

• fever
• sore throat
• skin rash
• mouth soreness or irritation

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep the liquid away from light. Do not freeze.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www. poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Fulvicin P/G^®¶
• Fulvicin-U/F^®¶
• Grifulvin V^®
• Gris-PEG^®
• Grisactin^®¶
• Ultragris^®¶

^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 06/15/2017

Browse Drugs and Medicines

Griseofulvin tablets 125mg №20 at a low price in Omsk, instructions for use, composition, analogues active substance

Griseofulvin

Manufacturer

Biosynthesis PAO

Instructions for use – Griseofulvin

Manufacturer

Biosintez, Russia

Composition

Active ingredient:

griseofulvin 125 mg.

Pharmacological action

Griseofulvin is an antifungal antibiotic.

Has a fungistatic effect.

Active against dermatophytes of the genera Trichophyton, Microsporum, Epidermophyton.

Inhibits cell division of fungal cells in metaphase by disrupting the structure of the mitotic spindle.

Griseofulvin accumulates to varying degrees in keratin precursor cells of the skin, hair and nails, making keratin resistant to fungal invasion.

As the infected keratin is separated, it is replaced by healthy tissue.

Indications

Mycoses of the skin, hair and nails, etc.

Contraindications

Hypersensitivity, systemic lupus erythematosus, liver and kidney diseases.

Side effects

From the side of the central nervous system: headache, dizziness, disorientation, unusual fatigue or weakness, insomnia, peripheral neuropathy, impaired coordination of movements, paresthesia of the extremities, confusion.

From the gastrointestinal tract: nausea, vomiting, diarrhea, gastralgia, candidal stomatitis, hepatitis.

From the side of hematopoiesis: granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: urticaria, skin rash, pruritus, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme exudative, Lyell’s syndrome.

Interaction

Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, anticoagulants of indirect action (due to the induction of microsomal liver enzymes).

Barbiturates and primidone reduce antifungal activity.

How to take, course of administration and dosage

Orally, during or after meals with vegetable oil.

In case of microsporia, children are prescribed at the rate of 21-22 mg per 1 kg of the patient’s body weight per day, adults – from 500 to 1000 mg (8 tablets per day).

The drug is taken daily until the first negative fungal test, then at the same dose every other day for 2 weeks and then 2 times a week for 2 weeks.

With trichophytosis (superficial and infiltrative-suppurative forms) and favus for children – at the rate of 18 mg/kg of body weight according to the same scheme as for microsporia.

For onychomycosis, trichophytosis and favus of the scalp, the daily dose for adults weighing up to 50 kg is 625 mg (5 tablets). The maximum daily dose is 1 g (8 tablets).

The daily dose in children and adolescents is 16 mg/kg body weight.

In case of onychomycosis, the drug is prescribed daily for the first month, every other day for the second month, then 2 times a week in the same daily dose until the nails grow completely.

The total duration of treatment is at least 8 months.

Special instructions

Treatment with Griseofulvin is carried out under the control of the morphological composition of the blood (1 time in 10-15 days).

Release form

Tablets

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf life

3 years 6 months

Active ingredient

Griseofulvin

Pharmacy conditions

Prescription

Formulation

tablets

Prescription

Prescription children, Prescription adults, Children over 3 years

Indications

Scalp fungus , Skin fungus, Fungus, Nail fungus

Barcode and weight

Barcode: 4602884000204

Weight: 0. 110 kg.

Griseofulvin tab 125mg №20 – Gorpharma

Instructions for use Griseofulvin 125mg 20 pcs. tablets
Composition and formulation
Description of dosage form
Pharmacological action
Pharmacokinetics
Pharmacodynamics
Indications for use
Contraindications for use
Use in pregnancy and children
Side effects
Drug interactions
Dosage
Overdose
Precautions
Composition and Presentation
Tablets – 1 tab.:

Active ingredient: Griseofulvin – 125 mg;
Excipients: lactose monohydrate (milk sugar) – 25.56 mg; calcium stearate – 1.80 mg; povidone (polyvinylpirollidone low molecular weight medical 12600 ± 2700, K-17) – 3.78 mg; potato starch – 23.86 mg.
10 tablets in a blister pack made of polyvinyl chloride film and printed lacquered aluminum foil.

2 blister packs with instructions for use of the drug in a pack of cardboard.

Description of dosage form
Tablets white or white with a yellowish tinge, flat-cylindrical, with a bevel.

Pharmacological action
Antifungal agent.

Pharmacokinetics
Absorption – high: microcrystalline form – 25-70%, ultramicrocrystalline form – almost 100%. Eating fatty foods enhances absorption. The time to reach the maximum concentration of the drug in plasma after oral administration is 4-5 hours, the maximum concentration of the drug in plasma is 0.5-5 mg / l. Communication with plasma proteins – 80%.

Selectively accumulates in the stratum corneum and its appendages, as well as in the liver, adipose tissue, and skeletal muscles. A small amount is distributed in body fluids and tissues. Penetrates through the placenta.

Metabolized in the liver with the formation of inactive metabolites (6-methyl-griseofulvin and glucuronide derivative).

The half-life of the drug is 24 hours.

Excreted by the kidneys (including 1% unchanged) and through the intestines (36% unchanged).

Pharmacodynamics
Antifungal antibiotic, effective against fungi of the genus Trichophyton, Microsporum, Epydermophyton Achorionum; causes disruption of the structure of the mitotic spindle and synthesis of the cell wall in chitin-containing fungi, inhibits the division of fungal cells in the metaphase and protein synthesis due to disruption of communication with matrix ribonucleic acid. It accumulates in the cells of the skin, hair and nails, which are precursors of keratin, making keratin resistant to fungal invasion. As the infected keratin is separated, it is replaced by healthy tissue.

Indications for use
Mycosis of the skin, hair and nails (microsporia, trichophytosis, favus, onychomycosis, epidermophytosis groin).

Contraindications for use
Hypersensitivity to griseofulvin or to any component of the drug, porphyria, systemic lupus erythematosus, lupus-like syndrome, systemic blood diseases, leukopenia, organic diseases of the liver and kidneys, liver failure, malignant neoplasms, pregnancy, breastfeeding, children age up to 3 years.

Use in pregnancy and children
The drug is contraindicated during pregnancy, as Griseofulvin crosses the placenta.

Breast-feeding should be discontinued during treatment.

Side effects
From the side of the nervous system: headache, dizziness, weakness, fatigue, insomnia, peripheral neuropathy, impaired coordination of movements, disorientation, paresthesia of the extremities, confusion.

From the digestive system: nausea, vomiting, diarrhea, gastralgia, candidal stomatitis, hepatitis.

From the side of hematopoiesis: granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: urticaria, skin rash, pruritus, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme exudative, toxic epidermal necrolysis (Lyell’s syndrome).

With widespread rashes, desensitizing therapy is carried out. If the rash continues to grow, griseofulvin should be discontinued for 3-4 days. After the disappearance of the rashes, the antibiotic is prescribed again, but starts with 1/2 tablet per day, and then the dose is gradually increased to the original one within 3-4 days.

Drug interaction
Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, indirect anticoagulants due to the induction of microsomal liver enzymes.

Barbiturates and primidone reduce antifungal activity.

Dosage
By mouth, during or after meals, in one or more doses.

Adults – at a daily dose of 500 mg. In severe mycoses, the dose is increased.

Children – at a daily dose of 10 mg/kg.

The duration of treatment for severe mycoses is up to 12 months. The course of treatment for damage to the skin of the body – 2-4 weeks, the scalp – 4-6 weeks, feet – 4-8 weeks, fingers – at least 4 months, toes – at least 6 months. The highest daily dose is 1 g.

Overdose
In case of overdose, symptomatic therapy and therapy to maintain vital organs and systems is recommended.

Precautions
Due to the negative impact on reproductive function (both in men and women), it is necessary to use effective non-hormonal methods of contraception.

Systemic griseofulvin is not used to treat mild infections for which topical antifungals alone are sufficient.

Influence on the ability to drive vehicles and control mechanisms

The potential for the development of such side effects as dizziness, drowsiness, impaired coordination of movements, disorientation, confusion should be taken into account.