How does bismuth subsalicylate suppress Helicobacter pylori infection. What role do bismuth and salicylate play in combating H. pylori. Can flagella suppression by salicylate explain the efficacy of bismuth subsalicylate against H. pylori. What are the implications for future H. pylori treatment strategies.

The Serendipitous Discovery of Bismuth Subsalicylate’s Effect on H. pylori

In a recent study published in Open Forum Infectious Diseases, Geng et al. reported an unexpected observation regarding the suppression of drug-resistant Helicobacter pylori infection using bismuth subsalicylate. This finding has sparked interest in the scientific community, prompting further investigation into the mechanisms behind this effect.

Dissecting Bismuth Subsalicylate: Bismuth vs. Salicylate

Bismuth subsalicylate is a compound consisting of two main components: bismuth and salicylate. While the authors of the original study focused on the potential effects of bismuth, there is compelling evidence suggesting that the salicylate component may play a crucial role in suppressing H. pylori infection.

The Role of Bismuth

Bismuth has been known to have antimicrobial properties and has been used in various treatments for gastrointestinal disorders. Its potential mechanisms of action against H. pylori include:

• Disruption of bacterial cell membranes
• Inhibition of bacterial enzymes
• Interference with bacterial adhesion to the gastric mucosa

The Salicylate Component: A Key Player?

While bismuth’s effects have been well-documented, the salicylate component of bismuth subsalicylate may be equally important in suppressing H. pylori infection. Recent research has highlighted the potential of salicylate to target a crucial aspect of H. pylori’s pathogenicity: its flagella.

H. pylori Flagella: A Critical Factor in Gastric Colonization

Helicobacter pylori’s ability to colonize the human gastric mucosa is largely dependent on its motility, which is facilitated by its flagella. These whip-like structures allow the bacteria to navigate through the thick mucus layer of the stomach and establish infection.

Evidence Supporting the Importance of Flagella

• Studies have shown that H. pylori’s motility plays a key role in colonizing the gastric mucosa
• Mice immunized with a vaccine targeting H. pylori flagella exhibited significantly reduced colonization
• The immune system has developed specific mechanisms to detect and respond to flagellated bacteria in the gut

Salicylate’s Effect on Bacterial Flagella

Recent research has uncovered a fascinating property of salicylate: its ability to reversibly block the synthesis of flagellin and flagella in gram-negative bacteria. This effect could have significant implications for H. pylori suppression.

How Does Salicylate Affect Flagella?

Salicylate interferes with the production of flagellin, the primary protein component of bacterial flagella. By inhibiting flagellin synthesis, salicylate effectively reduces bacterial motility, potentially hampering H. pylori’s ability to colonize the gastric mucosa.

The Immune System’s Response to Flagellated Bacteria

The human immune system has evolved sophisticated mechanisms to detect and respond to flagellated bacteria in the gut. Understanding these mechanisms can provide insights into how salicylate’s effect on flagella might contribute to H. pylori suppression.

Key Components of the Immune Response

• Toll-like receptor 5 (TLR5): Senses flagellin, the main component of bacterial flagella
• NOD-like receptor 4 (NLRC4): Activates the inflammasome upon detecting flagellin
• Inflammasome activation: Triggers the release of pro-inflammatory cytokines

By inhibiting flagellin synthesis, salicylate may not only reduce H. pylori’s motility but also potentially modulate the host immune response, leading to a more effective suppression of the infection.

Implications for H. pylori Treatment Strategies

The potential role of salicylate in suppressing H. pylori infection opens up new avenues for research and treatment development. Could targeting bacterial flagella be a novel approach to combating H. pylori infections, especially those resistant to conventional antibiotics?

Potential Treatment Approaches

1. Development of flagella-targeted vaccines
2. Exploration of other compounds that inhibit flagellin synthesis
3. Combination therapies that target both bacterial motility and other aspects of H. pylori pathogenicity

Future Research Directions

The observations made by Geng et al. and the subsequent analysis of the potential role of salicylate in H. pylori suppression raise several important questions for future research:

• What is the relative contribution of bismuth and salicylate to the overall efficacy of bismuth subsalicylate against H. pylori?
• Can the flagella-suppressing effect of salicylate be enhanced or optimized for more effective H. pylori treatment?
• Are there other compounds that exhibit similar effects on bacterial flagella that could be explored for H. pylori treatment?
• How does the inhibition of flagellin synthesis by salicylate affect the host immune response to H. pylori infection?

Answering these questions could lead to significant advancements in our understanding of H. pylori pathogenesis and the development of more effective treatment strategies.

The Broader Implications of Flagella Suppression in Bacterial Infections

While the focus of this discussion has been on H. pylori, the concept of targeting bacterial flagella as a means of infection control could have broader implications for other flagellated pathogens. Could the insights gained from studying salicylate’s effect on H. pylori be applied to other bacterial infections?

Potential Applications Beyond H. pylori

• Treatment of other gastrointestinal infections caused by flagellated bacteria
• Development of novel antimicrobial strategies for multidrug-resistant pathogens
• Exploration of flagella suppression as a means of reducing bacterial virulence without promoting antibiotic resistance

The potential of flagella suppression as a therapeutic strategy extends beyond H. pylori and could lead to innovative approaches in combating a wide range of bacterial infections.

Challenges and Considerations in Targeting Bacterial Flagella

While the prospect of targeting bacterial flagella for infection control is promising, several challenges and considerations must be addressed:

Potential Hurdles in Flagella-Targeted Therapies

1. Specificity: Ensuring that flagella-targeting treatments do not adversely affect beneficial gut bacteria
2. Resistance development: Investigating whether bacteria can develop resistance to flagella-suppressing compounds
3. Delivery methods: Developing effective ways to deliver flagella-targeting compounds to the site of infection
4. Long-term effects: Assessing the potential long-term consequences of interfering with bacterial motility in the gut microbiome

Addressing these challenges will be crucial in translating the insights gained from studying salicylate’s effect on H. pylori into practical therapeutic applications.

The Role of Combination Therapies in H. pylori Eradication

The potential synergy between bismuth and salicylate in bismuth subsalicylate highlights the importance of combination therapies in treating H. pylori infections. How can we leverage this understanding to develop more effective eradication strategies?

Advantages of Combination Approaches

• Targeting multiple aspects of bacterial pathogenicity simultaneously
• Reducing the likelihood of resistance development
• Potentially lowering required doses of individual components, minimizing side effects

Future research should focus on identifying optimal combinations of compounds that target different aspects of H. pylori’s lifecycle and virulence mechanisms.

The Importance of Host Factors in H. pylori Infection and Treatment

While much of the discussion has centered on bacterial factors, it’s crucial to consider the role of host factors in H. pylori infection and treatment outcomes. How do individual variations in immune response, gastric physiology, and genetics influence the efficacy of treatments like bismuth subsalicylate?

Key Host Factors to Consider

• Genetic polymorphisms affecting drug metabolism
• Variations in gastric acid production and mucus composition
• Differences in immune system reactivity to H. pylori antigens
• Pre-existing conditions that may affect treatment efficacy

Understanding these host factors could lead to more personalized and effective H. pylori treatment strategies.

The Global Impact of H. pylori and the Need for Innovative Treatments

Helicobacter pylori infection remains a significant global health concern, affecting a large portion of the world’s population and contributing to various gastric disorders, including peptic ulcers and gastric cancer. The emergence of antibiotic-resistant strains underscores the urgent need for novel treatment approaches.

The Scale of the H. pylori Problem

• Estimated global prevalence of H. pylori infection: 40-50% of the world’s population
• Higher prevalence in developing countries, often exceeding 80% in some regions
• Increasing rates of antibiotic resistance, complicating traditional treatment regimens

The potential of compounds like bismuth subsalicylate and the insights gained from studying their mechanisms of action could have far-reaching implications for global public health efforts to combat H. pylori infection.

Integrating Traditional Knowledge with Modern Science

The serendipitous discovery of bismuth subsalicylate’s effect on H. pylori serves as a reminder of the value of integrating traditional knowledge with modern scientific approaches. Many compounds used in traditional medicine may harbor unexpected therapeutic properties that could be harnessed through rigorous scientific investigation.

Bridging Traditional and Modern Approaches

1. Systematic screening of traditional remedies for anti-H. pylori activity
2. Investigating the molecular mechanisms behind traditional treatments
3. Combining traditional compounds with modern drug delivery techniques
4. Exploring potential synergies between traditional and conventional therapies

This integrative approach could lead to the discovery of novel treatment strategies not only for H. pylori but for a wide range of infectious diseases.

The Role of the Microbiome in H. pylori Infection and Treatment

Recent advancements in microbiome research have highlighted the complex interactions between H. pylori, the host, and the gastric microbiome. How does the presence of H. pylori affect the overall microbial ecosystem of the stomach, and how might this influence treatment outcomes?

Microbiome Considerations in H. pylori Treatment

• Impact of H. pylori on gastric microbial diversity
• Potential protective effects of certain commensal bacteria against H. pylori colonization
• Influence of the microbiome on drug metabolism and efficacy
• Long-term consequences of H. pylori eradication on the gastric microbiome

Understanding these complex interactions could lead to more holistic approaches to H. pylori management that consider the broader microbial context of the infection.

Ethical Considerations in H. pylori Research and Treatment

As we explore new avenues for H. pylori treatment, it’s crucial to consider the ethical implications of our research and clinical approaches. How do we balance the need for effective treatments with potential risks and long-term consequences?

Key Ethical Considerations

1. Balancing the benefits of H. pylori eradication with potential adverse effects on the microbiome
2. Ensuring equitable access to effective treatments, especially in resource-limited settings
3. Addressing the ethical challenges of human trials for new H. pylori therapies
4. Considering the potential environmental impact of widespread antibiotic use for H. pylori eradication

These ethical considerations should guide our research efforts and inform policy decisions regarding H. pylori management strategies.

The Future of H. pylori Research and Treatment

The discovery of bismuth subsalicylate’s effect on H. pylori and the subsequent exploration of its mechanisms of action represent just the beginning of a new chapter in H. pylori research. What does the future hold for our understanding and management of this ubiquitous pathogen?

Emerging Areas of Research

• Development of novel drug delivery systems for targeted H. pylori therapy
• Exploration of immunomodulatory approaches to enhance host defense against H. pylori
• Investigation of the long-term health consequences of H. pylori eradication
• Integration of artificial intelligence and machine learning in H. pylori diagnosis and treatment planning

As we continue to unravel the complexities of H. pylori infection and its interactions with the host, we move closer to more effective, personalized, and sustainable approaches to managing this significant global health challenge.

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate?

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Open Forum Infect Dis. 2022 Aug; 9(8): ofac413.

Published online 2022 Aug 11. doi: 10.1093/ofid/ofac413

Author information Article notes Copyright and License information Disclaimer

To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Potential conflicts of interest.
The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

1.
Geng C, Prokesch BC, Vemulapali R. Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate. Open Forum Infect Dis 2022; 9:ofac165. [PMC free article] [PubMed] [Google Scholar]

2.
Spohn G, Scarlato V. Motility, chemotaxis, and flagella. In: Mobley HLT, Mendz GL, Hazell SL, eds. Chapter 21: Helicobacter pylori: physiology and genetics. Washington, DC: ASM Press; 2001. [PubMed] [Google Scholar]

3.
Skene C, Young A, Every A, Sutton P. Helicobacter pylori flagella: antigenic profile and protective immunity. FEMS Microbiol Immunol 2007; 50:249–56. [PubMed] [Google Scholar]

4.
Ley RE, Gewirtz AT. Corralling colonic flagellated microbiota. N Engl J Med 2016; 375:85–7. [PubMed] [Google Scholar]

5.
Kunin CM, Tong HH, Bakaletz LO. Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp. Infect Immun 1995; 63:1796–9. [PMC free article] [PubMed] [Google Scholar]

Articles from Open Forum Infectious Diseases are provided here courtesy of Oxford University Press

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate? | Open Forum Infectious Diseases

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Calvin M Kunin

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Open Forum Infectious Diseases, Volume 9, Issue 8, August 2022, ofac413, https://doi. org/10.1093/ofid/ofac413

Published:

11 August 2022

Article history

Received:

29 July 2022

Editorial decision:

05 August 2022

Accepted:

09 August 2022

Published:

11 August 2022

Corrected and typeset:

22 August 2022

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To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Notes

Potential conflicts of interest. The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

1

Geng

C

,

Prokesch

BC

,

Vemulapali

R

.

Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate

.

Open Forum Infect Dis

2022

;

9

:

.

2

Spohn

G

,

Scarlato

V

. Motility, chemotaxis, and flagella. In:

Mobley

HLT

,

Mendz

GL

,

Hazell

SL

, eds.

Chapter 21: Helicobacter pylori: physiology and genetics

.

Washington, DC

:

ASM Press

;

2001

.

3

Skene

C

,

Young

A

,

Every

A

,

Sutton

P

.

Helicobacter pylori flagella: antigenic profile and protective immunity

.

FEMS Microbiol Immunol

2007

;

50

:

249

–

56

.

4

Ley

RE

,

Gewirtz

AT

.

Corralling colonic flagellated microbiota

.

N Engl J Med

2016

;

375

:

85

–

7

.

5

Kunin

CM

,

Tong

HH

,

Bakaletz

LO

.

Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp

.

Infect Immun

1995

;

63

:

1796

–

9

.

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]

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90,000 Helicobacter pylori. Who had it, how was it treated?

Helicobacter pylori. At …

Jun 18, 2018 02:59 PM

31 replies

Last –

May 12, 05:40 Go to

June 18, 2018, 15:13

#1

June 18, 2018, 15:15

900 02 #2

June 18, 2018, 03:27 PM

#3

June 18, 2018, 16:32

#4

Guest

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

18 June 2018 16:52

#5

18 June 2018 17:00

#6

9 0055 June 18, 2018 06:11 PM

#7

Guest

By the way, even the doctor told me this. You stuff yourself with strong antibiotics, and the next day you pick up this bacteria again in a cafe … With this helik, in general, everything is still not completely clear.

18 June 2018 20:19

#8

18 June 2018 21:29

#9

90 077 30 August 2018, 00:26

#10

Irina

Today I had an endoscopy, they did a test for Helicobacter pylori and it turned out to be sharply positive (three pluses). After tomorrow I will go to the gastroenterologist with the analysis, probably. prescribe antibiotics. Who faced similar? How was the treatment? What were the symptoms? Did your hair fall out? 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9January 11, 2019 Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

January 17, 2019 00:01

#13

February 21, 2019 12:40

#14

Evgenia

hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

September 22, 2019 12:05

#16

February 05, 2020 17:38

#17

Y awn

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

August 04, 2020, 19:58

#18

Guest

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively.

March 07, 2021 12:37

#19

February 24, 2022 16:12

#20

Y awn

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively. 15 August 2022 I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i. e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

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December 08, 2022, 09:46

#24

February 06, 14:03

#25

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already crying… fictional stories

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March 21, 08:23

#28

Guest

“A girlfriend was treated with the strongest antibiotics”.
And that her friend did not have the mind to be treated with propolis tincture? Propolis is much more effective than all antibiotics and without any side effects!
Doctors won’t prescribe you propolis, of course. They stuff you with different things

March 22, 17:59

#29

Guest

Good afternoon! And how to be treated with propolis tincture? What are the proportions?

May 10, 10:46 AM

#30

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already bursting into tears ….

Attention

May 12, 05:40

#31

Guest

You will be prescribed everything by a doctor .. There are antibiotics and a bunch of other drugs. Treatment for a month – then repeat. It is necessary to treat the whole family – to be honest, because. eat and drink from the same glasses. Do not treat – the next stage is cancer..

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Helicobacter pylori bacterium, how to treat?

Helicobacter bacterium . ..

September 07, 2016, 11:15

42 responses

Last –

July 06, 2021, 09:55 Go to

September 07, 2016, 12:25

#1

September 07, 2016, 12:29 9000 3

#2

September 07, 2016, 12:29

#3

September 07, 2016 12:36

#4

September 07, 2016 13:19

#5

robicheva

I was treated with both de-nol and ulcavis, but I did not see any difference in effect.

September 07, 2016, 13:21

#6 0647 September 07, 2016, 02:41 PM

#8

Guest

20% propolis was advised. .. The tests were in the clinic..positive. Also ginger 2 hours before meals with tea.. Nothing else helps.. Again it comes back.

September 07, 2016, 14:50

#9

September 07, 2016 03:07 PM

#10

September 07, 2016 04:28 PM

9 0002 #11

Guest

The same yaytsa, only in profile, not even import substitution.
The active substance is identical, the difference in the amount is 0.3%.
The problem is rather the presence of resistant strains, and a shorter “therapeutic window” than SOME bismuth-free drugs used in multicomponent regimens or as mono(-antimicrobial-) therapy.
Helic is an opportunistic pathogen, in minimal quantities it is present in 90% of those living near rivers, wetlands.
If there is a lot of it, bismuth preparations and other AMHT have the function of “buying time” (treatment of the main metabolic defect, chronic burn or frostbite of the upper gastrointestinal tract, etc. .).
The term “eradication therapy”, which has taken root in medicine, is somewhat incorrect; eradication is significant in terms of removal from the bloodstream, submucosal layers, cellular spaces in various microbial associations, and not just from the body (intestinal lumen, mucosal surface).

September 07, 2016, 16:29

#12

Guest

20% propolis advised… Tests were in the clinic..positive Also ginger 2 hours before meals with tea.. Nothing else helps. .It comes back again.

September 07, 2016, 16:29

#13

robicheva

The doctor prescribed de-nol for me, but after completing the course of treatment with this medicine, I didn’t get rid of the problems, because as it turned out, helicobacter was only a complex of drugs , including antibiotics can be cured. Already again after a few months, when it became clear that I had not got rid of the problem, I was prescribed De-nol, only in combination with antibiotics and an inhibitor. And in the pharmacy, my favorite pharmacist advised Ulcavis, it is much cheaper.

September 07, 2016, 18:46

#14

September 07, 2016, 21:20

#15

roksana.visloukhova

Significantly, as much as almost 2 times.

September 07, 2016, 09:37

#16

September 08, 2016, 08:25

#17

roksana.visloukhova

Significantly, as much as almost 2 times.

September 08, 2016, 11:32 AM

#18

Lyusechka Ionova

Is it possible to save on health?

September 08, 2016, 15:26

#19

roksana.visloukhova

Yes, look at the composition: bismuth tripotassium dicitrate 303.03 mg, excipients: corn starch ny – 72. 17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate

September 08, 2016, 20:17

#20

Lusechka Ionova body substances: corn starch – 72.17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate
Really almost identical medicines…. But de-nol has more bismuth!

September 09, 2016, 11:35

#21

September 09, 2016, 16:43

#22

robicheva

The main thing is that it helps!

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September 09, 2016, 21:09

#23

September 10, 2016, 08:27

#24

September 11, 2016 11:29 AM

#25

September 11, 2016, 04:53 PM

#26

Lyusechka Ionova

As far as I know, you still need to follow a strict diet in addition to drugs

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• How can I help my mother? September 11, 2016 18:57

  #27

  roksana. visloukhova

  Of course, this is one of the main conditions for recovery, and only then, along with the diet, taking medications.

  September 12, 2016, 08:48

  #28

  Lyusechka Ionova

  Has your sister been tested?

  September 12, 2016, 17:49

  #29

  September 12, 2016, 20:42

  How could they prescribe medicines for her without the necessary tests?

  September 13, 2016, 09:09

  #31

  September 13, 2016, 13:30

  #32

  September 13, 2016, 03:19 PM

  #33

  September 16, 2016, 06:03 PM

  #34

  Lyusechka Ionova

  That’s good! Only now I doubt that I only need Ulcavis, especially in the analyzes this terrible bacterium! It is necessary to clarify with the doctor again how we will destroy it!

  September 16, 2016, 19:40

  #35

  October 03, 2016, 13:45

  #36

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  January 03, 2017, 23:50

  #38

  Lyusechka Ionova

  I don’t know anything about this medicine, I read that this bacterium is usually treated with De-nol. Has anyone been treated with Ulcavis?

  September 18, 2017 02:37 PM

  #39

  October 11, 2017 01:12 PM

  #40

  December 06, 2017, 03:04 PM

  #41

  Guest

  Proton pump inhibitor + metronidazole + antibiotic. Wash all utensils with soap and disinfect daily. I drank a week, or 10 days, I forgot about a ten-year gastritis. I read the treatment regimen on the Internet, since the gastroenterologist, an old aunt, does not read anything except serials, and I have never heard about the treatment of Helicobacter. It was in 2008.

  September 02, 2018, 11:26

  #42

  April 08, 2019, 20:45

  #42

  robicheva

  The doctor prescribed de-nol for me, but after completing the course of treatment with this medicine to the end I didn’t get rid of the problems, because as it turned out, Helicobacter pylori can be cured only with a complex of drugs, including antibiotics.