How much Benadryl is safe to take. What are the recommended dosages for different age groups. How to properly measure Benadryl doses. What are the risks of taking too much Benadryl.

Understanding Benadryl and Its Uses

Benadryl is a widely used over-the-counter medication containing the active ingredient diphenhydramine. This antihistamine is primarily used to alleviate symptoms associated with allergies, hay fever, and the common cold. Its versatility extends to treating itchy skin conditions caused by insect bites, hives, eczema, and sunburn. Additionally, Benadryl can help with motion sickness and insomnia.

Available in various forms, Benadryl can be found as:

• Oral formulations: tablets, chewable tablets, liquid-filled capsules, liqui-gels, and liquid solutions
• Topical applications: creams, gels, and sprays

Some combination products incorporate diphenhydramine with other active ingredients. For instance, Benadryl Allergy Plus Congestion for Sinus Pressure & Nasal Congestion Relief combines diphenhydramine with phenylephrine, a nasal decongestant.

Recommended Benadryl Dosages for Different Age Groups

Determining the correct Benadryl dosage depends on several factors, including the condition being treated, the patient’s age, and the specific formulation being used. Healthcare professionals recommend using the lowest effective dose for the shortest duration possible.

For Hay Fever, Allergies, and Common Cold Symptoms

• Adults and children 12 years and older: 25 mg to 50 mg every 4 to 6 hours
• Children 6-12 years old: 12.5 mg to 25 mg every 4 to 6 hours
• Children under 6 years: Should not take oral Benadryl without a doctor’s prescription

For Itchy Skin Conditions

Adults and children 2 years and older can use topical Benadryl formulations as directed on the product label.

Proper Measurement and Administration of Benadryl

Accurate measurement of Benadryl doses is crucial for safe and effective use. Here are some guidelines to follow:

• Use syringes or droppers for liquid formulations, as they are more accurate than teaspoons
• If possible, use the measuring device provided with the medication
• When using a teaspoon, ensure it’s a measuring spoon, not a regular spoon
• Remember: 1 level teaspoon equals 5 ml, and ½ teaspoon equals 2.5 ml

For Children’s Benadryl FastMelts, each tablet contains the equivalent of 12.5 mg of Diphenhydramine HCl and should be dosed the same as chewable tablets.

Benadryl Dosage Table for Children

The following table provides a guide for dosing Benadryl in children based on their weight:

Important Considerations for Benadryl Use in Children

When administering Benadryl to children, keep these points in mind:

• For allergies: Not recommended for children under 1 year of age due to its sedative effects
• For colds: Not recommended at any age due to lack of proven benefits, and should be avoided in children under 4 years old
• Multi-ingredient products: Avoid use in children under 6 years of age, as per FDA recommendations from October 2008

Risks and Side Effects of Benadryl Overuse

While Benadryl is generally safe when used as directed, taking too much can lead to severe side effects. Common side effects of Benadryl include drowsiness, dry mouth, and dizziness. However, excessive use or overdose can result in more serious complications:

• Severe drowsiness and confusion
• Rapid heartbeat
• Blurred vision
• Difficulty urinating
• Constipation
• In extreme cases, seizures or hallucinations

Is it possible to develop a tolerance to Benadryl? Yes, regular use of Benadryl can lead to tolerance, meaning you may need higher doses to achieve the same effect. This can increase the risk of side effects and potential for dependence.

Safe Practices for Benadryl Use

To ensure safe use of Benadryl, follow these guidelines:

1. Always read the product label and follow dosing instructions carefully
2. Do not exceed the recommended dose or frequency of use
3. Consult a healthcare professional before giving Benadryl to children under 6 years old
4. Avoid using Benadryl with other medications containing diphenhydramine
5. Be cautious when combining Benadryl with other sedating medications or alcohol
6. If symptoms persist or worsen, seek medical advice

Can Benadryl be used long-term for chronic conditions? While Benadryl can be effective for short-term symptom relief, it’s not recommended for long-term use without medical supervision. Chronic conditions may require different treatment approaches.

Alternatives to Benadryl for Allergy Relief

For those seeking alternatives to Benadryl, especially for long-term allergy management, consider these options:

• Non-sedating antihistamines: Cetirizine (Zyrtec), loratadine (Claritin), or fexofenadine (Allegra)
• Nasal corticosteroids: Fluticasone (Flonase) or mometasone (Nasonex)
• Natural remedies: Saline nasal sprays, neti pots, or local honey (for seasonal allergies)
• Lifestyle changes: Using air purifiers, keeping windows closed during high pollen days, and regular cleaning to reduce allergens

Are there any non-drowsy alternatives to Benadryl? Yes, second-generation antihistamines like Zyrtec, Claritin, and Allegra are less likely to cause drowsiness while still providing effective allergy relief.

When to Seek Medical Attention

While Benadryl is generally safe when used as directed, there are situations where medical attention may be necessary:

• Allergic reactions to Benadryl itself (rare, but possible)
• Symptoms of overdose, such as extreme drowsiness, confusion, or rapid heartbeat
• Persistent or worsening symptoms despite proper use of Benadryl
• Development of new or unexplained symptoms
• Concern about interactions with other medications or health conditions

How quickly should symptoms improve after taking Benadryl? Typically, Benadryl begins to work within 30 minutes to an hour. If symptoms don’t improve or worsen after several doses, consult a healthcare provider.

Special Considerations for Benadryl Use

Certain groups should exercise caution when using Benadryl:

• Elderly individuals: More susceptible to side effects, especially confusion and dizziness
• Pregnant or breastfeeding women: Should consult a healthcare provider before use
• People with certain medical conditions: Including glaucoma, enlarged prostate, or liver disease
• Those taking other medications: Benadryl can interact with various drugs, including antidepressants and other antihistamines

Can Benadryl affect cognitive function in older adults? Yes, regular use of Benadryl in older adults has been associated with an increased risk of cognitive decline. Alternative treatments should be considered for this population when possible.

The Future of Antihistamine Treatment

As research in allergy treatment continues to advance, new approaches are being developed:

• Targeted therapies: Medications that focus on specific allergy pathways in the body
• Immunotherapy: Long-term treatments that help build tolerance to specific allergens
• Combination therapies: Products that combine antihistamines with other active ingredients for more comprehensive symptom relief
• Personalized medicine: Tailoring allergy treatments based on an individual’s genetic profile and specific allergen sensitivities

What new antihistamine treatments are on the horizon? Researchers are exploring novel antihistamines with fewer side effects and longer-lasting action. Additionally, biologics that target specific immune system components involved in allergic reactions are showing promise in clinical trials.

In conclusion, while Benadryl remains a valuable tool for managing allergies and related symptoms, it’s crucial to use it responsibly and be aware of its limitations and potential risks. By following proper dosing guidelines, considering alternatives when appropriate, and staying informed about new developments in allergy treatment, individuals can effectively manage their symptoms while minimizing potential side effects. Always consult with a healthcare professional for personalized advice on managing allergies and using medications like Benadryl safely and effectively.

Diphenhydramine – Benadryl etc – Dosage Table | Health & Wellness Library | University Hospitals Rainbow Babies & Children’s Hospital | Cleveland, OH

Indications:

Treatment of allergic reactions, nasal allergies, hives and itching.

Table Notes:

• AGE LIMITS: For allergies, don’t use under 1 year of age (Reason: it’s a sedative). For colds, not recommended at any age (Reason: no proven benefits) and should be avoided if under 4 years old. Avoid multi-ingredient products in children under 6 years of age (Reason: FDA recommendations 10/2008).
• DOSAGE: Determine by finding child’s weight in the top row of the dosage table
• MEASURING the DOSAGE: Syringes and droppers are more accurate than teaspoons. If possible, use the syringe or dropper that comes with the medication.  If not, medicine syringes are available at pharmacies. If you use a teaspoon, it should be a measuring spoon. Regular spoons are not reliable. Also, remember that 1 level teaspoon equals 5 ml and that ½ teaspoon equals 2.5 ml.
• ADULT DOSAGE: 50 mg
• FREQUENCY: Repeat every six hours as needed
• CHILDREN’S BENADRYL FASTMELTS: Each fastmelt tablet contains the equivalent of 12.5 mg of Diphenhydramine HCL and dosed the same as chewable tablets.

Author and Senior Reviewer: Barton D. Schmitt, M.D.
Content Set: Pediatric HouseCalls Symptom Checker
Pediatric HouseCalls Symptom Checker

How Much Benadryl Can I Take Safely?

Written by
Juhi Modi

Medically reviewed by
HaVy Ngo-Hamilton, Pharm.D.
| May 25, 2022

Benadryl is a common over-the-counter medicine used to relieve symptoms of allergic rhinitis (hay fever) and the common cold, such as runny nose, sneezing, and watery/itchy eyes. It is also used to provide relief from irritated or itchy skin caused by insect bites, hives, eczema, sunburn, and other medical conditions like motion sickness and insomnia. All in all, it has a great variety of uses.

While it is an effective drug, the risk with exemplary over-the-counter medications like Benadryl is that you can easily continue taking it for symptomatic relief without noticing that you are going over the recommended dosage. Doing so can lead to severe side effects. 

This article will discuss the appropriate doses and the risks of taking too much Benadryl.

What is Benadryl?

Brand name Benadryl contains the active ingredient diphenhydramine. It is an over-the-counter antihistamine that helps relieve symptoms of seasonal allergies, the common cold, and itchy skin due to bug bites or allergic reactions. 

Benadryl is available in many different forms, including:

• Oral (to be taken by mouth): tablets, chewable tablets, liquid-filled capsules,liqui-gels, and liquid solution
• Topical (to be applied to the skin): creams, gels, and sprays

Some combination products contain diphenhydramine as the main ingredient along with other ingredients. For example, Benadryl Allergy Plus Congestion for Sinus Pressure & Nasal Congestion Relief contains diphenhydramine, an antihistamine, and phenylephrine, a nasal decongestant.

What is the correct Benadryl dosage?

The correct Benadryl dosage depends on several factors. Among those factors is the condition you’re treating, your age, and the form of Benadryl you’re using. Your physician will advise you to take the lowest effective dose of Benadryl for the shortest possible time as best practice recommends.

Regarding effective Benadryl dosing, commonly used and recommended doses of Benadryl are as follows:

For hay fever, allergies, and common cold symptoms

The recommended dose for adults and children 12 years and older is 25 mg to 50 mg every 4 to 6 hours. 

The recommended dose for children between the ages of 6-12 is 12.5 mg to 25 mg every 4 to 6 hours. 

Children under the age of 6 e should not take oral Benadryl without a doctor’s prescription. 

For itchy skin from insect bites, stings, hives, allergic reactions, or other causes

Adults and children from age 2+ can use the topical form of Benadryl and apply gel, cream, or spray to the affected area up to 4 times daily unless the area is widespread and the oral form is advised by a healthcare professional. Children under 2 years of age should use Benadryl topical products only if advised by a physician.

This is a general dosing guide. Some patients, for example, elderly patients, may need to take lower doses of this medication. If you have any specific questions about Benadryl dosages regarding your age and condition, you should consult your doctor or pharmacist. 

What is the maximum dosage of Benadryl?

The maximum dose of Benadryl for adults and children over 12 years of age is 300 mg per day. The maximum dose of Benadryl for children between the ages of  6 to 12 is 150 mg per day. Do not take more than 6 doses of oral Benadryl in 24 hours. 

Benadryl topical products (creams, gels, sprays) should not be applied to the skin more than 4 times a day.

It is important to check all your other antihistamines and ensure that your other medications don’t contain the same active ingredient, i.e., diphenhydramine. The maximum dose mentioned above is the dose you can safely take from all products and different forms combined.

What are Benadryl’s side effects?

The common side effects of Benadryl include sleepiness, dizziness, headache, dry mouth, dry eyes, and weakness. If these symptoms are severe or do not go away after a few days, talk to your doctor or pharmacist.

Benadryl can also cause more serious side effects, such as problems with cognition (thinking),  memory, fast heartbeat (tachycardia), and seizures. Contact your doctor if you experience these side effects and seek emergency medical care for serious side effects such as seizures. 

What are Benadryl risks and drug interactions?

Benadryl can cause drowsiness, which can impair your ability to drive, operate heavy machinery, or do anything that requires focus. Falling asleep at the wheel can result in accidents, so follow your doctor’s instructions and do not drive while taking Benadryl until you know how this medication affects you.

If you are taking other drugs, talk to a healthcare provider before taking Benadryl to avoid serious drug interactions. For example, taking Benadryl with benzodiazepines (Valium, Xanax, Klonopin) can increase the risk of confusion, drowsiness, and delirium. Mixing Benadryl and alcohol can lead to drowsiness and sedation, increasing the risk of accidents and injuries.

How many days in a row can you take Benadryl?

You should not use over-the-counter (OTC) Benadryl for longer than 7 days as treatment for cold and allergy symptoms. OTC Benadryl is intended for short-term use to provide temporary relief of allergy symptoms. If your symptoms do not improve after a week of Benadryl use, contact your doctor to obtain an accurate diagnosis and discuss alternative treatments.

What happens if you take too much Benadryl?

Scientists do not know a lot about the side effects of taking Benadryl long-term, but it has been linked to conditions such as:

• Constipation
• Weight gain
• Blurred vision
• Hallucinations 
• Memory problems, confusion, dementia
• Restless legs syndrome
• Depression and anxiety
• Tolerance and dependence

Can you overdose on Benadryl?

Yes, you can overdose on Benadryl. Signs and symptoms of a Benadryl overdose may include:

• Confusion
• Blurred vision
• Dry mouth
• Dizziness
• Heart arrhythmia
• Difficulty breathing
• Irritability
• Restlessness
• Confusion
• Hallucinations
• Shock
• Seizures
• Coma
• Death

If you or someone you know may have overdosed on Benadryl, call 911 or seek care at the nearest emergency room without delay.

Wrapping Up: Safe use of over the counter medications like Benadryl

It is not safe to take more than the recommended dosage of over-the-counter medicines like Benadryl. Taking too much Benadryl can cause serious problems, including hallucinations, abnormal heart rhythms, seizures, and even death. Always read the labels on OTC medications carefully and ensure that you take the recommended daily dosage. 

References:

1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=702f9786-7ce9-43e4-921d-e1db09612127
2. https://medlineplus.