Pepcid Dosage Guide – Drugs.com

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Generic name: FAMOTIDINE 20mg
Dosage form: tablet, film coated
Drug class: h3 antagonists

Medically reviewed by Drugs.com. Last updated on Oct 24, 2022.

Recommended Dosage

Table 1 shows the recommended dosage of PEPCID 20 mg and 40 mg tablets in adult and pediatric patients weighing 40 kg and greater with normal renal function. The use of PEPCID 20 mg and 40 mg tablets is not recommended in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Use another famotidine formulation for pediatric patients weighing less than 40 kg.

Dosage in Renal Impairment

Dosage adjustments of PEPCID are recommended for patients with moderate to severe renal impairment (creatinine clearance less than 60 mL/min) [see Use in Specific Populations (8. 6)]. Table 2 shows the recommended maximum dosage of PEPCID 20 mg or 40 mg tablets for patients with renal impairment, by indication. Use the lowest effective dose. Some dosage adjustments may require switching to other formulations of famotidine (e.g., oral suspension, lower dose tablet).

Administration Instructions

•

Take PEPCID once daily before bedtime or twice daily in the morning and before bedtime, as recommended.

•

PEPCID may be taken with or without food [see Clinical Pharmacology (12.3)].

PEPCID may be given with antacids.

Frequently asked questions

• Is famotidine safer than omeprazole for heartburn?
• Can you take famotidine long term?
• Can I take omeprazole in the morning and famotidine at night?

More about Pepcid (famotidine)

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• Reviews (10)
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• Dosage information
• During pregnancy
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• Drug class: h3 antagonists
• Breastfeeding
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Patient resources

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Heartburn Relief

Professional resources

• Prescribing Information

Other formulations

• Pepcid AC

Related treatment guides

• GERD
• Duodenal Ulcer Prophylaxis
• Erosive Esophagitis
• Duodenal Ulcer

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Frequently Asked Questions | PEPCID®

HEARTBURN BASICS

QA Text: 

QA Question: 

What causes heartburn?

Heartburn is triggered by a variety of things, but the main cause is stomach acid escaping the stomach into the esophagus and causing a burning feeling. A normally functioning lower esophageal sphincter (LES) should keep the contents of your stomach from escaping, but sometimes the LES relaxes or weakens, and allows acid to flow into the esophagus.

Common heartburn triggers are certain types of foods and beverages, smoking, and stress. They can increase stomach acid or relax the LES. Learn more about heartburn, its triggers, and how to manage it.

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QA Question: 

What are some of the most common triggers of heartburn?

What triggers heartburn is not the same for everyone, but some of the most common heartburn triggers include certain types of foods – for example, anything that is greasy, spicy, or fatty.
Take our Triggers Quiz to find out if you have heartburn or find out more about diet tips that can help you prevent heartburn.

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PEPCID® VS OTHER HEARTBURN RELIEF

QA Text: 

QA Question: 

What types of heartburn relief are available over the counter?

There are 3 main types of heartburn relief products you can buy at the store without a prescription that offer a range from quick relief to longer-lasting relief:

Antacids neutralize the acid in your stomach, but don’t stop your stomach from making more. Antacids start neutralizing acid in seconds, and may last up to 2 hours on a full stomach.

Histamine-2 blockers (h3 blockers) lower the amount of acid that your stomach produces, giving you lasting relief that goes to work quickly. PEPCID® is an h3 blocker. Both Original Strength and Maximum Strength PEPCID AC® begin to work in 15-30 minutes, and help control acid all day or all night. * Dual Action PEPCID COMPLETE® combines an h3 blocker with an antacid, so it starts neutralizing acid in seconds, but has the long-lasting relief of an h3 blocker.

*Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.

Proton Pump Inhibitors (PPIs) work by shutting down pumps that release acid into your stomach. PPIs are not intended for immediate relief of heartburn. They may take 1–4 days for full effect, and require daily dosing for 14 days.

Learn more about how PEPCID® compares to other types of heartburn relief.

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QA Question: 

What is the difference between PEPCID® and a PPI like Prilosec OTC® or Nexium® 24HR?

Both Pepcid, a histamine-2 blocker, and a Proton Pump Inhibitor (PPI) decrease the amount of acid in your stomach, but work in different ways. Learn more about h3s vs. PPIs

HISTAMINE-2 (h3) BLOCKERS, INCLUDING PEPCID®

• Relieves heartburn associated with acid indigestion or sour stomach
• Block the histamine receptors that trigger acid production
• Can be taken when unexpected heartburn occurs
• PEPCID Complete® combines an h3 blocker with an antacid, so it starts to neutralize acid in seconds
• PEPCID AC ®  starts to work in 15-30 minutes
• PEPCID ®  controls acid all day or all night*
• Original Strength PEPCID AC® and Maximum Strength PEPCID AC® can even prevent heartburn if taken 15 to 60 minutes before a meal.

*Based on 9 hour acid control studies during the day and 12 hour acid control studies during the night. Acid control does not imply symptom relief.

PROTON PUMP INHIBITORS (PPIs)

• Treat frequent heartburn
• Are not indicated for the prevention of heartburn (over-the-counter)
• Shut down pumps that release acid
• Are not intended for immediate relief
• May take 1-4 days to become fully effective
• Have to be taken every day for 14 days
• Can last for up to 24 hours

Third party trademarks used herein are trademarks of their respective owners.

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ABOUT PEPCID®

QA Text: 

QA Question: 

Does PEPCID® treat or prevent COVID-19?

PEPCID® is a histamine-2 blocker with the active ingredient famotidine. PEPCID® is indicated to relieve or prevent heartburn associated with acid indigestion and sour stomach brought on by eating or drinking certain food and beverages.

PEPCID® is not indicated for the treatment or prevention of COVID-19.

Each person should speak to their healthcare provider about what treatment option may be right for them for their individual condition or needs.

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QA Question: 

What is PEPCID®?

PEPCID® is a histamine-2 blocker (h3 blocker) that provides relief for heartburn. The active ingredient in PEPCID® products is famotidine, an h3 blocker that helps relieve heartburn by reducing the amount of acid in the stomach. PEPCID® comes in three forms: Original Strength PEPCID AC^®,  Maximum Strength PEPCID AC^®, and PEPCID Complete^® . Learn more about PEPCID^®.

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QA Question: 

What is famotidine, and what is it used for?

Famotidine is the active ingredient in PEPCID® and is a histamine-2 blocker. Famotidine works by decreasing the amount of acid the stomach produces.

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QA Question: 

How does PEPCID® work?

PEPCID® helps to relieve heartburn by lowering the amount of acid your stomach produces. It blocks the histamine receptors that trigger stomach acid production, thereby decreasing the amount of acid the stomach produces and providing lasting relief. Learn more about how PEPCID® works.

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QA Question: 

When should I take PEPCID®?

PEPCID® can be used if you suffer from occasional heartburn. It can be taken whenever you have unexpected heartburn. Learn more about PEPCID® so you can know how it works to help relieve your heartburn.

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QA Question: 

How often can I take PEPCID®?

Use PEPCID® as directed on the product label. Do not take more than 2 tablets in 24 hours. If you find that you need to use PEPCID® for more than 14 days, stop use and consult a doctor.

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QA Question: 

How long does it take for PEPCID® to work and how long does it last?

PEPCID® works fast and lasts all day or all night. * PEPCID Complete^® combines a histamine-2 blocker with an antacid, so it starts working in seconds and lasts all day or all night.* A regular antacid may only work for a few hours. Original Strength PEPCID AC^® and Maximum Strength PEPCID AC^® are h3 blockers, and start to work within 15-30 minutes and controls acid all day or all night.*

*Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.

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QA Question: 

Can I take PEPCID® to prevent heartburn?

PEPCID AC® provides heartburn relief that starts working in minutes, and controls acid all day or all night,* but it can even prevent heartburn if taken 15 to 60 minutes before a meal.

*Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.

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QA Question: 

Can PEPCID® be crushed?

Use PEPCID® as directed on the product label. Do not crush tablets. Swallow whole with a glass of water. Do not chew.

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QA Question: 

What is PEPCID Complete®?

PEPCID Complete^® combines the long lasting effects of an acid-reducing histamine-2 blocker (famotidine) with the speed of an antacid (calcium carbonate and magnesium hydroxide) to help relieve symptoms in two different ways:

h3 blockers decrease the production of new stomach acid by blocking the histamine receptors that trigger stomach acid production, thereby providing lasting relief.

Antacids neutralize acid that is already present in the stomach, thereby giving fast relief.

PEPCID Complete® is a single tablet that both reduces and neutralizes acid.

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QA Question: 

Why does the label for PEPCID Complete® list both calcium carbonate & magnesium hydroxide and elemental calcium & elemental magnesium?

The active ingredients of PEPCID Complete^® include famotidine 10 mg, calcium carbonate 800 mg and magnesium hydroxide 165 mg. Calcium carbonate and magnesium hydroxide are the salt forms of elemental or base calcium and magnesium. Calcium carbonate contains 40% elemental calcium, which means that the 800 mg of calcium carbonate in PEPCID Complete® contains 320 mg of elemental calcium. Magnesium hydroxide contains 42% elemental magnesium, which means that the 165 mg of magnesium hydroxide in PEPCID Complete® contains 70 mg elemental magnesium. Since calcium carbonate and magnesium hydroxide are active ingredients in PEPCID Complete®, they are listed in the “active ingredients” section of the drug facts label. The “additional information” section of the drug facts label lists the total amounts of base or elemental calcium and magnesium content of the product, as required by the FDA.

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QA Question: 

I have a question regarding prescribing information for prescription PEPCID®

For inquiries regarding the prescribing information for prescription PEPCID®, please call Marathon Company at 1-866-562-4620.

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QA Question: 

Why should I not use PEPCID® if I have trouble or pain swallowing food?

The “Do not use if you have trouble or pain swallowing” statement appears on the labels of all acid reducers, and is based on the condition being treated rather than the drug itself. The rationale for this warning is that trouble swallowing may indicate a more severe underlying disease state than just heartburn alone. It is recommended that if you have trouble swallowing, you should consult your physician before using this product.

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QA Question: 

Can I take PEPCID® for GERD (gastroesophageal reflux disease)?

PEPCID® products are not indicated for the treatment of GERD.

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QA Question: 

Do PEPCID® products contain gluten?

Gluten or gluten-containing grains are not ingredients in the product. However, we do not currently test our final products for gluten, and we cannot confirm that the product or any ingredients in the product are free of gluten. We strongly recommend that if you have any form of gluten intolerance or sensitivity, you should consult your doctor before taking any medication, since he or she is most familiar with your medical history.

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PEPCID® SAFETY

QA Text: 

QA Question: 

Can a PEPCID® product be taken while on Proton Pump Inhibitor (PPI) therapy?

PEPCID ®  should not be used with other acid reducers, such as PPIs.

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QA Question: 

Are there interactions between grapefruit juice and PEPCID®?

We are not aware of any published reports of interactions between grapefruit juice and famotidine, the active ingredient in Original Strength PEPCID AC® AC and Maximum Strength PEPCID AC®, and one of the active ingredients in PEPCID Complete®.

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QA Question: 

Can you drink alcohol while taking famotidine?

Avoid drinking alcohol to help prevent heartburn. Alcohol is a potential trigger for heartburn.

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QA Question: 

Can you take PEPCID® while pregnant?

If you are pregnant or breastfeeding, consult with your doctor before using PEPCID®.

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film-coated tablets, lyophilisate for solution for intravenous administration, 20 mg, 40 mg

film-coated tablets 20 mg blister pack, 40 mg blister pack —
In a dry, dark place, at a temperature not exceeding 25 °C.
film-coated tablets 40 mg blister, 20 mg blister —
At a temperature not exceeding 25 ° C, in the original packaging (in a pack).
film-coated tablets 40 mg blister pack, 20 mg blister pack —
In a place protected from light, at a temperature not exceeding 25 ° C.
film-coated tablets 20 mg blister pack —
At a temperature not higher than 25 °C.

Keep out of reach of children.

film-coated tablets 20 mg blister pack, 40 mg blister pack – 3 years.
film-coated tablets 40 mg blister pack, 20 mg blister pack – 4 years.

Do not use after the expiry date which is stated on the packaging.

White to pale yellow crystalline compound, readily soluble in glacial (anhydrous) acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Molecular weight 337.43 Da.

Mechanism of action

Famotidine is a competitive inhibitor of H ₂ histamine receptors. The main clinically important pharmacological action of famotidine is the inhibition of gastric secretion. Famotidine suppresses both the concentration of acid and the volume of gastric secretion, while changes in pepsin secretion are proportional to its volume.

Pharmacodynamics

adults

Famotids inhibits both basal and nightstock secretion, as well as secretion stimulated by food and pentagastine. After oral administration, the antisecretory effect occurs within 1 hour, the maximum effect depends on the dose and occurs within 1-3 hours. The duration of secretion inhibition with doses of 20 and 40 mg is from 10 to 12 hours.

Single evening oral doses of 20 and 40 mg suppressed basal and nocturnal gastric acid secretion in all patients, mean nocturnal gastric acid secretion was suppressed by 86 and 94%, respectively, for a period of at least 10 hours. Famotidine at the same doses (20 and 40 mg ) taken in the morning suppressed food-stimulated acid secretion in all patients. The average level of suppression of acid secretion was 76 and 84%, respectively, 3-5 hours after administration and 25 and 30%, respectively, 8-10 hours after administration. However, in some patients treated with famotidine at a dose of 20 mg, the antisecretory effect subsided within 6-8 hours. No cumulative effect was observed with multiple doses. Evening administration of famotidine at doses of 20 and 40 mg increased the nocturnal intragastric pH to mean values ​​of 5 and 6.4, respectively. Administration of famotidine at doses of 20 and 40 mg in the morning after a meal increased the daily basal intragastric pH to approximately 5 at 3 and 8 hours after administration.

Taking famotidine in the morning on an empty stomach or after a meal had virtually no effect on serum gastrin levels. Famotidine did not affect gastric emptying and exocrine pancreatic function.

In studies of clinical pharmacology of famotidine, no systemic effects on the central nervous system, cardiovascular system, respiratory or endocrine systems were noted. No antiandrogenic effects were also noted. Serum hormone levels, including prolactin, cortisol, thyroxine (T ₄ ) and testosterone, did not change after oral administration of famotidine.

Children

The pharmacodynamics of famotidine based on gastric pH was evaluated in 5 patients aged 2 to 13 years using a sigmoid model E _max . The data obtained indicate that the relationship between the concentration of famotidine in the blood serum and the suppression of gastric acidity is similar to that observed in adults (see table 1).

Table 1

Serum concentrations of famotidine associated with decreased gastric acidity in children and adults treated with famotidine

Population	EC 50 ng/ml 1
Children	26 ±13
Adults:
– healthy adults, volunteers	26. 5± 10.3
– adult patients with bleeding from the upper gastrointestinal tract	18.7 ± 10.8

¹ Using the sigmoid curve for determining E 9 0033 max famotidine serum concentrations at which decrease in gastric acidity by 50% of the maximum, are presented as mean values ​​± standard deviation.

In a study of the effect of famotidine on gastric pH and duration of acid suppression in children in 4 patients aged 11 to 15 years who took oral famotidine at a dose of 0.5 mg/kg, gastric pH remained above 5 for (13.5 ±1.8) h. The bioavailability of oral doses is 40-45%. Bioavailability may be slightly increased by food intake or slightly decreased by antacids, but these effects are not of clinical significance.

T _max famotidine in plasma is 1-3 hours. Plasma concentration after multiple doses is similar to that after a single dose.

Distribution

From 15 to 20% of famotidine binds to plasma proteins.

Metabolism

Famotidine undergoes minimal first pass metabolism. From 25 to 30% of the oral dose is excreted in the urine as unchanged compound. The only metabolite identified in humans is S-oxide.

Elimination of

T _1/2 famotidine is 2.5–3.5 hours. Famotidine is eliminated by the renal (65–70%) and metabolic (30–35%) routes. Renal clearance is 250–450 ml/min, indicating some tubular secretion.

Special patient groups

Children. Bioavailability studies in 8 patients aged 11 to 15 years showed a mean oral bioavailability of 0.5 compared to adult values ​​of 0.42-0.49. In children aged 11 to 15 years, the AUC was (580 ± 60) ng h/mL with famotidine 0.5 mg/kg orally, compared with (482 ± 181) ng h/mL in adults treated with 40 mg famotidine orally.

Renal insufficiency. In adult patients with severely impaired renal function (Cl creatinine <30 ml / min), the AUC of famotidine increased at least 5 times. In patients with moderate renal impairment (Cl creatinine 30-60 ml / min), the AUC of famotidine increased at least 2-fold (see “Precautions”).

Drug interaction studies

Organic anion transporter 1 and 3 (OAT1 and OAT3). In vitro studies”> in vitro showed that famotidine is a substrate of OAT1 and OAT3. After co-administration of probenecid (1500 mg), an inhibitor of OAT1 and OAT3, and 20 mg of famotidine in 8 healthy volunteers AUC _0-10 famotidine in serum increased from 424 to 768 ng h / ml, and C _max from 73 to 113 ng / ml. Renal clearance, urinary excretion rate and the amount of famotidine excreted unchanged in the urine were reduced. Clinical significance this interaction is unknown.0014

Multiple drug and toxin transporter (MATE1). An in vitro study”> in vitro showed that famotidine is an inhibitor of MATE1. However, no clinically significant interaction with metformin, a substrate of MATE1, was observed.

CYP1A2. Famotidine is a weak inhibitor of CYP1A2.

9 0024 Carcinogenicity, mutagenicity , effects on fertility

The carcinogenic potential of famotidine was evaluated in a 106-week oral study in rats and 92-week oral study in mice. In a 106-week study in rats and a 92-week study in mice at oral doses up to 2000 mg/kg/day (approximately 243 and 122 times the recommended human dose (80 mg/day) in the treatment of erosive esophagitis, based on area body surface), there was no evidence of the carcinogenic potential of famotidine.

Famotidine was negative in the mutagenic activity test (Ames test) using Salmonella typhimurium and Escherichia coli with or without activation of rat liver enzymes at concentrations up to 10,000 µg/dish (Petri). No evidence of mutagenic potential of famotidine was found in in vivo”> ​​ in vivo mice in mouse lymphoma cell micronucleus and chromosome aberration tests.

243 times the recommended human dose (80 mg/day) based on body surface area), famotidine had no effect on fertility or reproductive function.

Clinical studies

Active duodenal ulcer colon, famotidine was compared with oral placebo. As shown in Table 2, 70% of patients treated with famotidine 40 mg at night were cured by week 4. In most patients, complete healing of duodenal ulcers occurred within 4 weeks.

Patients who were not cured by week 4 remained in the study. By week 8, healing of duodenal ulcers occurred in 83% of patients treated with famotidine compared with 45% of patients treated with placebo. The frequency of healing of duodenal ulcers with famotidine was higher than with placebo at each time point, based on the proportion of endoscopically confirmed healing of duodenal ulcers. The study did not evaluate the safety of taking famotidine for uncomplicated active duodenal ulcer for more than 8 weeks.

Table 2

Patients with endoscopically confirmed healing of duodenal ulcers ¹

900 70

¹ p<0. 001 vs. placebo.

In this study, the time to resolution of daytime and nighttime pain was shorter in patients treated with famotidine compared with those treated with placebo. Patients who received famotidine also took fewer antacids compared with patients who received placebo.

Active gastric ulcer

In both US and international multicentre, double-blind studies in patients with endoscopically confirmed active gastric ulcer, oral famotidine 40 mg at night was compared with placebo. During the studies, antacids were allowed, but their use did not show significant differences between the famotidine and placebo groups.

As shown in Table 3, endoscopy-proven gastric ulcer healing rates (patients with unhealed gastric ulcers were considered dropouts) were higher with famotidine than with placebo at weeks 6 and 8 in a US study , and at 4, 6 and 8 weeks in an international study. In these studies, most patients treated with famotidine were cured within 6 weeks. Studies have not evaluated the safety of taking famotidine for more than 8 weeks of uncomplicated active gastric ulcer.

Table 3

Patients with endoscopically confirmed healing of gastric ulcers

1 p≤0.01 vs placebo.

² p≤0.05 vs. placebo.

The time to complete resolution of daytime and nighttime pain was statistically significantly shorter in patients treated with famotidine tablets compared with patients treated with placebo, but no study showed a statistically significant difference in the proportion of patients who experienced pain relief by the end of the study (by the 8th week).

Symptomatic GERD

In a US study in patients with symptomatic GERD and no endoscopic evidence of esophageal erosion or ulceration, oral famotidine was compared with placebo. As shown in Table 4, patients treated with famotidine 20 mg twice daily experienced a greater improvement in GERD symptoms than those treated with famotidine 40 mg at night or placebo.

Table 4

Patients with improvement in GERD symptoms (n=376)

¹ p≤0. 01 vs placebo.

Erosive esophagitis due to GERD

Healing of endoscopically confirmed erosions and improvement in symptoms was studied in a US and international double-blind study. Healing was defined as complete resolution of all erosions seen on endoscopy. In a US study comparing oral famotidine 40 mg twice daily with placebo and oral famotidine 20 mg twice daily, there was a significantly greater percentage of healing of erosive esophagitis at weeks 6 and 12 (table 5).

Table 5

Patients with endoscopically confirmed healing of erosive esophagitis in the US study (n=318)

¹ p≤0. 01 vs. Pla cebo.

² p≤0.01 compared with famotidine 20 mg twice daily.

³ p≤0.05 compared with famotidine 20 mg twice daily.

In a US study, patients treated with famotidine experienced faster resolution of daytime and nocturnal heartburn, and a greater proportion of patients experienced complete resolution of nocturnal heartburn compared with placebo. These differences were assessed as statistically significant.

In an international study comparing oral famotidine 40 mg twice daily with oral ranitidine 150 mg twice daily, there was a statistically significantly higher percentage of healing of erosive esophagitis when taking famotidine at week 12 (Table 6) . However, there were no significant differences in symptom relief between treatment groups.

Table 6

Patients with endoscopically confirmed healing of erosive esophagitis in an international study (n=440)

^{≤0. 05 compared to ranitidine 150 mg twice daily.}

Pathological hypersecretory conditions

In studies involving patients with pathological hypersecretory conditions such as Zollinger-Ellison syndrome with or without multiple endocrine neoplasms, famotidine significantly suppressed gastric acid secretion and controlled associated symptoms. Oral famotidine at a dose of 20 to 160 mg every 6 hours maintained basal acid secretion below 10 mEq/h, initial doses were titrated according to individual needs, followed by dose adjustment during therapy in some patients.

Reduced risk of duodenal ulcer recurrence

Two randomized, double-blind, multicenter trials in patients with endoscopically confirmed complete healing of duodenal ulcer showed a reduction in duodenal ulcer recurrence in patients receiving oral famotidine at doses of e 20 mg at night, compared with placebo.

In a US study, recurrence of duodenal ulcer within 12 months was 2.4 times more common in patients treated with placebo than in patients treated with famotidine. 89In patients treated with famotidine, the cumulative observed rate of recurrence of duodenal ulcer was 23% compared with 57% in 89 patients treated with placebo (p<0.01).

In an international study, the cumulative observed 12-month recurrence rate of duodenal ulcer in 307 patients treated with famotidine was 36% compared with 76% in 325 patients treated with placebo (p<0.01).

The duration of controlled studies did not exceed 1 year.

History of hypersensitivity (eg, anaphylaxis) to famotidine or other H ₂ receptor antagonists.

Clinical study experience

Because clinical studies are conducted in a variety of settings, the frequency of adverse reactions observed in one clinical study cannot be directly compared with the frequency observed in another clinical study and may not reflect the frequency observed in practice.

A total of 1442 patients were treated with famotidine, including 302 patients – 40 mg 2 times a day, 456 patients – 20 mg 2 times a day, 461 patients – 40 mg 1 time per day and 396 patients – 20 mg 1 time per day. Patient age ranged from 17 years to 91 years, patients were quite well distributed by gender and race, however, the Caucasian race predominated.

In these studies, the following adverse reactions were reported with a frequency of ≥1%: headache, dizziness and constipation.

The following adverse reactions have been reported with a frequency of <1%.

On the part of the body as a whole: fever (fever), asthenia, fatigue.

From the side of the CCC: palpitations.

From the gastrointestinal tract: increased levels of liver enzymes, vomiting, nausea, abdominal discomfort, anorexia, dry mouth.

Blood side: thrombocytopenia.

Hypersensitivity reactions: eye oedema (swelling of the orbital tissues), rash, conjunctival injection, bronchospasm.

From the musculoskeletal system: musculoskeletal pain, arthralgia.

From the side of the nervous system / mental disorders: convulsions, hallucinations, depression, anxiety, decreased libido, insomnia, drowsiness.

Skin: skin itching, dry skin, redness.

From the senses: tinnitus, taste disorders.

Other: impotence.

Post-registration observations

The following adverse reactions have been reported in the post-registration period of famotidine use. Since data on these reactions are obtained from spontaneous reports from an indeterminate population, it is not possible to reliably estimate their frequency or establish a causal relationship with famotidine exposure.

From the side of the CCC: arrhythmia, AV blockade, prolongation of the QT interval.

From the gastrointestinal tract: cholestatic jaundice, hepatitis.

Blood disorders: agranulocytosis, pancytopenia, leukopenia.

Hypersensitivity reactions: anaphylaxis, angioedema, facial edema, urticaria.

From the musculoskeletal system: rhabdomyolysis, muscle cramps.

From the side of the nervous system / mental disorders: confusion, agitation, paresthesia.

From the respiratory system: interstitial pneumonia.

Skin disorders: toxic epidermal necrolysis/Stevens-Johnson syndrome.

Oral, once a day at night or twice a day – in the morning and at night, can be taken on an empty stomach or with meals. The dosage regimen and duration of treatment depend on the disease, the status of the patient and are determined by the attending physician.

Can I give my dog ​​Pepcid twice a day?

Contents

A typical dose of famotidine administered is 0.25 to 0.5 mg per pound (0.5 to 1.0 mg/kg) every 12 to 24 hours. The effect decreases when taken for more than 14 days in a row. For this reason, it may be recommended to take twice a day.

How often can I give my dog ​​Pepsid?

Pepcid Dosage for Dogs: For both dogs and cats, the dose is one 10-milligram tablet for a 20-pound dog every 12-24 hours, says Dr. Klein. It is best to give this medicine one hour before meals.

What happens if I give my dog ​​too much Pepcid?

Famotidine overdose is rare, but overdose symptoms may include: Vomiting. Anxiety. Redness of the mouth and ears.

Can I give my dog ​​20 mg Pepcid?

If your dog has gas, you can use Famotidine, the generic version of pepsid for dogs! Famotidine for Dogs 20mg is used to relieve various medical problems such as stomach inflammation, acid reflux and more! This easy-to-use formula provides long-lasting relief for your stressed pets!

How long does it take for Pepsid to work in dogs?

This medicine should work within 1-2 hours; however, the effects may not be noticeable and your veterinarian may need to run laboratory tests to evaluate if the medication is working.

How much pepcid can I give my 50 lb dog?

The usual dose of famotidine for dogs is 0.25 mg to 0.5 mg per pound of body weight twice daily.

Can Pepcid be given to a dog after a meal?

If needed to protect your dog’s stomach from an irritant medication, you will give it on an empty stomach half an hour before you give the prescribed medication. If there is food in the stomach, the famotidine in Pepcid AC cannot coat the stomach effectively, causing irritation.

Will Pepcid help my dog’s upset stomach?

The use of famotidine may reduce nausea in dogs through its action on the chemoreceptor trigger zone. Pepsid is used to treat pets with stomach ulcers, esophagitis, gastric reflux, esophageal reflux, Helicobacter infections, and/or vomiting.

How much famotidine can I give my 10 lb dog?

Tablets are available in 10, 20 and 40 mg doses and the powder must be measured for correct dosage. The recommended dosage is often 0.22 to 0.44 mg per pound of dog weight.

Can I give my dog ​​Pepcid for acid reflux?

Pepcid® is a short-acting drug that lasts up to 24 hours. The duration may be longer in dogs with kidney or liver disease. Pepcid® may also be recommended for dogs on medication or for dogs diagnosed with conditions that irritate the stomach or cause increased gastric acid secretion.

Can Pepcid AC harm my dog?

Pepcid AC can be used in dogs (short-term use only)

This histamine blocker can be used on animals. In fact, it is considered quite safe for reducing stomach acid levels and even helps stomach ulcers by allowing for more effective healing.

How many antacids can I give my dog?

The dose most commonly used in dogs as an antacid is 0.5 grams and up to 5 grams total dose orally every 4 hours as needed. Small dogs may receive 500 mg, medium-sized dogs 750 to 1000 mg, and larger dogs 2000 mg.

What can I give a dog with acid reflux?

Sucralfate (brand names: Carafate® and Sulcrate®) is often given as a suspension (suspended in water) to dogs with GERD. This allows sucralfate to coat the esophagus, protecting its delicate lining and slowing the progression of esophageal inflammation and ulcers.

Can dogs take famotidine every day?

Continued administration of famotidine results in a reduced effect on intragastric pH in dogs. Caution is advised in recommending long-term daily oral famotidine in dogs.

Can Pepsid be taken 3 times a day?

Do not exceed 2 tablets in 24 hours unless directed by a physician. Do not use for more than 14 days in a row without consulting your doctor.

Can I give my dog ​​omeprazole twice a day?

In dogs and cats, twice daily administration of omeprazole is more effective in reducing gastric acid secretion than once daily administration.

What does acid reflux look like in dogs?

Mild gastroesophageal reflux usually presents with profuse salivation (drooling), regurgitation, vomiting, belching, and bad breath. Dogs with gastric reflux often lick the air obsessively in an attempt to swallow the rising stomach fluid.

What soothes a dog’s stomach?

Chicken and rice are the main ingredients in many dog ​​foods and these bland foods are good for indigestion in dogs. In addition, this simple dish is easy to prepare. All you need is skinless and boneless chicken breasts and rice.

How to treat chronic gastritis in dogs?

How is gastritis treated?

1. refrain from eating for 24 to 48 hours.
2. offer small amounts of water frequently during the first 24 hours (if liquid cannot be given orally without inducing vomiting, seek immediate veterinary care)
3. If there is no vomiting within 24 hours, feed a small amount of easily digestible lean food.

Can famotidine be taken twice a day?

It is usually taken once a day at bedtime or two to four times a day. Famotidine is available over-the-counter as tablets, chewable tablets, and oral capsules. It is usually taken once or twice a day.

Can Pepcid be taken 8 hours apart?

Adults? 20 milligrams (mg) every 6 hours. Your doctor may change your dose as needed.

Why can’t I take more than 2 Pepcid in 24 hours?

Chew and swallow one tablet to relieve symptoms of heartburn. Do not take more than 2 tablets in 24 hours because if you take more than the recommended dose of famotidine (Pepcid Complete), you may increase your risk of side effects from the medication.

How many times a day can a dog take omeprazole?

Omeprazole for dogs should be given 30-60 minutes before meals to minimize stomach acid. Although omeprazole can be taken once a day, studies have shown that taking every 12 hours is more effective than taking it once a day.

How often can I give my dog ​​omeprazole?

Omeprazole Dosage Information for Dogs and Cats

A typical dose administered to dogs and cats is 0.25 to 0.5 mg per pound (0.5 to 1.0 mg/kg) every 24 hours or once a day.

How long does it take for a dog to recover from gastroenteritis?

Fortunately, with timely and proper treatment, gastroenteritis in dogs resolves within a few days to a week. However, if the situation does not seem to be getting worse or you notice blood in the stool, return the child to the veterinarian as soon as possible for further treatment.

Why does my dog’s acid reflux get worse at night?

At night, the esophageal sphincter relaxes during sleep, making the dog more likely to vomit in the morning if it has eaten before bed. Smaller but more frequent meals can also help prevent a dog from vomiting bile, which usually happens on an empty stomach.

Does pumpkin help dogs with acid reflux?

In the fight against indigestion and indigestion in dogs, 100% canned pumpkin is a favorite of many veterinarians. “It has a low glycemic index, so it’s slowly absorbed, which helps with indigestion and indigestion,” says Dr. Birman.

Why do dogs vomit white foam?

White, frothy vomit is often caused by excessive secretion and ingestion of saliva, which may be a symptom of nausea. Ingestion of grass, plant material, or other things that are unfamiliar or difficult for the dog to digest can cause vomiting. Toxins can irritate the gastrointestinal tract and even worse, often leading to vomiting.

What over-the-counter medications can I give my dog ​​for an upset stomach?

Antidiarrheals/Anti-nausea. Bismuth subsalicylate (Pepto-Bismol®) is commonly stocked in a first aid kit for indigestion and can be given to a dog.

Is peanut butter good for an upset stomach in a dog?

For this reason, feeding your dog cheese or other dairy products can cause diarrhea and other digestive problems. It should be avoided as a snack for dogs. Peanut Butter: This is a very popular dog treat, and most of the time, it doesn’t pose a risk to your pet.

Why does my dog ​​keep getting gastroenteritis?

Causes of gastroenteritis in dogs

Ingestion of spoiled or raw foods or non-food items. Viruses (parvovirus, distemper, etc.). intestinal parasites. Changes in the intestinal flora.

What to feed a dog with gastritis?

Diet change

This means giving them foods that won’t upset their stomach. They can include low-fat options like boiled rice, pasta, potatoes, pumpkin, and some proteins like boiled skinless chicken, ground beef, also boiled, tofu, and even fat-free cottage cheese.

What causes stomach inflammation in dogs?

Causes of gastritis

Acute gastritis is common in dogs. Most cases are caused by dietary indiscretion, which means your dog ate something they shouldn’t have eaten. Foreign Objects: If your dog eats a foreign object that is not food, it can cause inflammation of the stomach lining and cause gastritis.

When should I take famotidine twice a day?

Take Famotidine tablets once a day at bedtime, or twice a day in the morning and before bedtime, as recommended. Famotidine tablets can be taken with or without food. Famotidine tablets can be administered with antacids.

What is the maximum daily dose of famotidine?

What is the maximum dose of famotidine? For most indications and for over-the-counter use, the maximum dose of famotidine is 40 mg per day, although it is also prescribed at 40 mg twice daily under medical supervision.

Can the dose of PEPCID 20 mg be halved?

You can take famotidine with or without food. Take this drug at the time recommended by your doctor. The tablet can be cut or crushed. Not every pharmacy has this drug.

Is it better to take famotidine in the morning or in the evening?

Conclusion. Famotidine 10 mg 1 hour before dinner is a successful and well-tolerated strategy for the prevention of postprandial heartburn and associated sleep disturbance.

Is famotidine the same as pepsid?

PEPSID ^® is the original brand name of famotidine and has been an effective and safe acid reducer when used as directed for 35 years.