How often is it safe to use glycerin suppositories for constipation. What are the proper usage instructions for laxative suppositories. Are there any risks or side effects associated with frequent suppository use. When should you consult a doctor about chronic constipation instead of relying on laxatives.

Understanding Glycerin Suppositories and Their Uses

Glycerin suppositories are a type of laxative used to provide relief from occasional constipation. They work by drawing water into the intestines, which helps soften stools and stimulate bowel movements. While generally safe when used as directed, it’s important to understand proper usage and potential risks.

These suppositories are typically used for:

• Treating occasional constipation
• Cleansing the bowel before certain medical procedures
• Providing relief from hard, dry stools

Can glycerin suppositories be used for other purposes? While their primary use is for constipation relief, some healthcare providers may recommend them for other gastrointestinal issues. However, it’s crucial to only use them for purposes explicitly approved by a medical professional.

Proper Usage Instructions for Glycerin Suppositories

Using glycerin suppositories correctly is essential for their effectiveness and safety. Here are the key steps:

1. Wash your hands thoroughly before and after use
2. Remove the wrapper from the suppository
3. Lie on your left side with your lower leg straight and upper leg bent
4. Gently insert the suppository into the rectum, pointed tip first
5. Insert about 1 inch for adults or 1/2 inch for children
6. Remain lying down for a few minutes to allow the suppository to melt

How long does it take for a glycerin suppository to work? Typically, you should experience a bowel movement within 15 to 60 minutes after insertion. If no bowel movement occurs within an hour, consult your healthcare provider.

Frequency of Use: How Often is Safe?

The frequency of glycerin suppository use is a crucial consideration for maintaining digestive health. Overuse can lead to dependence and other complications.

What is the recommended frequency for using glycerin suppositories? Generally, it’s advisable not to use them more than once in a 24-hour period. However, they should not be used regularly for extended periods.

Is it safe to use glycerin suppositories daily? Daily use is not recommended. These suppositories are intended for occasional use only. Prolonged use can lead to:

• Electrolyte imbalances
• Dehydration
• Dependency on laxatives
• Weakening of natural bowel function

Potential Risks and Side Effects of Frequent Use

While glycerin suppositories are generally safe when used as directed, frequent or prolonged use can lead to various side effects and risks.

What are the common side effects of glycerin suppositories? Some users may experience:

• Rectal irritation or burning
• Abdominal cramping
• Nausea
• Diarrhea

Can overuse of glycerin suppositories cause long-term problems? Yes, excessive use can lead to more serious issues such as:

• Chronic constipation
• Damage to the nerves and muscles in the intestines
• Increased risk of electrolyte imbalances
• Dependency on laxatives for bowel movements

Special Considerations for Different Age Groups

The use of glycerin suppositories varies depending on age, with special considerations for children and older adults.

Are glycerin suppositories safe for children? While there are pediatric formulations available, it’s crucial to:

• Use only products specifically designed for children
• Consult a pediatrician before use in children under 2 years old
• Follow age-appropriate dosing instructions carefully

How should older adults approach the use of glycerin suppositories? Older adults should:

• Consult their healthcare provider before use
• Be aware of potential interactions with other medications
• Monitor for signs of dehydration or electrolyte imbalances

Alternatives to Glycerin Suppositories for Constipation Relief

While glycerin suppositories can be effective, there are numerous alternatives for managing constipation.

What are some natural alternatives to glycerin suppositories? Consider trying:

• Increased fiber intake through diet or supplements
• Adequate hydration
• Regular exercise
• Probiotic supplements
• Herbal teas like senna or dandelion

Are there other over-the-counter options for constipation relief? Yes, alternatives include:

• Stool softeners
• Osmotic laxatives
• Bulk-forming laxatives
• Lubricant laxatives

When to Consult a Healthcare Professional

While occasional use of glycerin suppositories is generally safe, certain situations warrant medical attention.

When should you see a doctor about constipation instead of using suppositories? Consult a healthcare professional if:

• Constipation persists for more than two weeks
• You experience severe abdominal pain
• There’s blood in your stool
• You’re losing weight unexpectedly
• You’re using laxatives regularly for an extended period

Could frequent constipation be a sign of a more serious condition? Yes, chronic constipation can sometimes indicate underlying health issues such as:

• Irritable bowel syndrome (IBS)
• Thyroid problems
• Diabetes
• Neurological disorders
• Certain types of cancer

Proper Storage and Handling of Glycerin Suppositories

Correct storage and handling of glycerin suppositories are crucial for maintaining their effectiveness and safety.

How should glycerin suppositories be stored? Follow these guidelines:

• Keep at room temperature, away from direct heat and sunlight
• Store in a dry place to prevent melting
• Keep out of reach of children
• Check expiration dates regularly and dispose of expired products

What precautions should be taken when handling glycerin suppositories? Remember to:

• Wash hands thoroughly before and after use
• Avoid touching the suppository excessively to prevent melting
• Use the provided applicator if available
• Never share suppositories with others

Understanding the Importance of Proper Bowel Health

While glycerin suppositories can provide relief from occasional constipation, it’s essential to understand the broader context of bowel health.

Why is maintaining regular bowel movements important? Regular bowel movements are crucial for:

• Eliminating waste and toxins from the body
• Maintaining a healthy gut microbiome
• Preventing complications like hemorrhoids or anal fissures
• Supporting overall digestive health

How can you promote natural bowel regularity? Consider these lifestyle changes:

• Eating a balanced diet rich in fiber
• Staying well-hydrated throughout the day
• Engaging in regular physical activity
• Managing stress through relaxation techniques
• Establishing a regular bathroom routine

The Role of Diet in Preventing Constipation

Diet plays a significant role in maintaining healthy bowel function and preventing constipation.

Which foods can help prevent constipation? Include these in your diet:

• High-fiber fruits like apples, pears, and prunes
• Leafy green vegetables
• Whole grains and cereals
• Legumes and beans
• Nuts and seeds

Are there any foods that might contribute to constipation? Be cautious with:

• Processed foods high in fat and sugar
• Dairy products (for some individuals)
• Red meat
• Alcohol and caffeine in excess

Understanding the Digestive System and Constipation

To better manage constipation, it’s helpful to understand how the digestive system works.

What are the main components of the digestive system involved in constipation? Key parts include:

• The large intestine (colon)
• The rectum
• The anal sphincter

How does the digestive process relate to constipation? Constipation can occur when:

• The colon absorbs too much water from the stool
• Muscle contractions in the intestines are slow or sluggish
• There’s a blockage in the colon or rectum
• The pelvic muscles don’t relax properly during a bowel movement

The Impact of Lifestyle on Bowel Health

Various lifestyle factors can significantly influence bowel health and the likelihood of experiencing constipation.

How does physical activity affect bowel movements? Regular exercise can:

• Stimulate intestinal contractions
• Reduce transit time of stool through the colon
• Improve overall digestive health
• Help maintain a healthy body weight, which can positively impact bowel function

What role does stress play in constipation? Stress can contribute to constipation by:

• Altering gut motility
• Affecting hormones that regulate digestion
• Leading to unhealthy eating habits
• Causing tension in the pelvic and abdominal muscles

The Importance of Hydration for Bowel Health

Proper hydration is crucial for maintaining regular bowel movements and preventing constipation.

How does water intake affect bowel function? Adequate hydration:

• Helps soften stool, making it easier to pass
• Supports the mucus lining in the intestines
• Aids in the absorption and transport of nutrients
• Helps prevent the colon from absorbing too much water from stool

What are good sources of hydration besides water? Consider:

• Herbal teas
• Fresh fruits and vegetables with high water content
• Clear soups and broths
• Coconut water

Understanding Different Types of Laxatives

While glycerin suppositories are one type of laxative, there are several other categories, each working differently to relieve constipation.

What are the main types of laxatives? The primary categories include:

• Bulk-forming laxatives: Add bulk to stool, promoting bowel movements
• Osmotic laxatives: Draw water into the intestines to soften stool
• Stimulant laxatives: Increase intestinal contractions
• Lubricant laxatives: Coat the intestines to ease stool passage
• Stool softeners: Increase water content of stool

How do different laxatives compare in terms of safety and effectiveness? Considerations include:

• Bulk-forming laxatives are generally considered the safest for long-term use
• Osmotic laxatives are effective but can cause electrolyte imbalances if overused
• Stimulant laxatives work quickly but can lead to dependence if used regularly
• Lubricant laxatives are gentle but may interfere with nutrient absorption if used long-term
• Stool softeners are mild and safe for most people but may not be effective for severe constipation

Potential Complications of Chronic Constipation

While occasional constipation is common, chronic constipation can lead to various complications if left untreated.

What are potential complications of long-term constipation? Risks include:

• Hemorrhoids
• Anal fissures
• Fecal impaction
• Rectal prolapse
• Urinary tract infections

How can these complications be prevented? Prevention strategies include:

• Addressing constipation promptly
• Maintaining a healthy diet and lifestyle
• Using laxatives judiciously and under medical guidance
• Seeking medical attention for persistent constipation
• Practicing good toilet habits, such as not straining during bowel movements

Fleet Glycerin Suppositories Adult rectal Uses, Side Effects & Warnings

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Generic name: glycerin (rectal) [ GLISS-er-in ]
Brand names: Fleet Glycerin Suppositories Adult, Fleet Glycerin Suppositories Pediatric, Pedia-Lax Liquid, Sani-Supp
Drug class: Laxatives

Medically reviewed by Drugs.com on Sep 13, 2022. Written by Cerner Multum.

What is Fleet Glycerin Suppositories Adult rectal?

Fleet Glycerin Suppositories Adult rectal is used as a laxative. It works by causing the intestines to hold more water, which softens the stool.

Fleet Glycerin Suppositories Adult rectal is used to treat occasional constipation or to cleanse the bowel before a rectal exam or other intestinal procedure.

Fleet Glycerin Suppositories Adult rectal may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Fleet Fleet Glycerin Suppositories Adult Suppositories Adult if you are allergic to Fleet Glycerin Suppositories Adult.

To make sure Fleet Glycerin Suppositories Adult rectal is safe for you, tell your doctor if you have:

• nausea, vomiting, or stomach pain;

• rectal bleeding;

• a change in bowel habits that has lasted for 2 weeks or longer;

• ulcerative colitis, toxic megacolon; or

• if you have used another laxative for longer than 1 week.

FDA pregnancy category C. It is not known whether Fleet Glycerin Suppositories Adult rectal will harm an unborn baby. Do not use this medicine without a doctor’s advice if you are pregnant.

It is not known whether glycerin rectal passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor’s advice if you are breast-feeding a baby.

When using this medication in any child, use only the forms that are specially made for children. Certain brands of Fleet Glycerin Suppositories Adult rectal should not be used in children.

Do not use Fleet Glycerin Suppositories Adult rectal in a child younger than 2 years old without the advice of a doctor.

How should I use Fleet Glycerin Suppositories Adult rectal?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Overuse of a laxative may cause damage to the nerves, muscles, or tissues in your intestines.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after using a rectal enema or suppository.

This medicine comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

To use the suppository:

• Remove the wrapper before inserting the suppository. Avoid handling the suppository too long or it will melt in your hands.

• Use your finger or the applicator provided to insert the suppository.

• Lie on your left side with your lower leg straight and your upper leg bent. Gently insert the suppository pointed tip first into your rectum, about 1/2 inch for a child or 1 inch for an adult.

• For best results, stay lying down for a few minutes. The suppository will melt quickly and you should feel little or no discomfort while holding it in.

To use the enema:

• Remove the protective shield before inserting the enema tip.

• Lie on your left side with your lower leg straight and your upper leg bent. If giving this medicine to a child, have the child kneel on the floor and then lower the chest forward until the side of the child’s face is resting on the floor.

• Gently insert the tip of the applicator or bulb syringe into the rectum, pointing it toward your navel (belly button). Do not force the applicator into the rectum or injury could result.

• Slowly squeeze the bottle or bulb until it is nearly empty.

For best results after using Fleet Glycerin Suppositories Adult rectal, stay lying down until you feel the urge to have a bowel movement. This medicine should produce a bowel movement within 15 to 60 minutes after using the suppository.

Do not use Fleet Glycerin Suppositories Adult rectal more than once in a 24-hour period.

Call your doctor if this medication does not cause you to have a bowel movement within 1 hour after use.

Store the rectal enema at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Store the rectal suppositories at cool room temperature away from moisture and heat. Some suppositories can be refrigerated. Check your medicine label to be sure how to store your medicine.

What happens if I miss a dose?

Since Fleet Fleet Glycerin Suppositories Adult Suppositories Adult is usually given only once as needed, you will not be on a dosing schedule. Do not use Fleet Fleet Glycerin Suppositories Adult Suppositories Adult rectal more than once in a 24-hour period.

What happens if I overdose?

An overdose of Fleet Glycerin Suppositories Adult rectal is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Fleet Glycerin Suppositories Adult rectal?

Avoid using other laxatives in combination with Fleet Glycerin Suppositories Adult rectal unless your doctor has told you to.

Fleet Glycerin Suppositories Adult rectal side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Fleet Glycerin Suppositories Adult rectal may cause serious side effects. Stop using Fleet Glycerin Suppositories Adult rectal and call your doctor at once if you have:

Common side effects of Fleet Glycerin Suppositories Adult may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fleet Glycerin Suppositories Adult rectal?

Other drugs may interact with glycerin rectal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Fleet Glycerin Suppositories Adult (glycerin)

• Check interactions
• Compare alternatives
• Reviews (9)
• Side effects
• Dosage information
• During pregnancy
• Drug class: laxatives
• En español

Patient resources

Other brands

Pedia-Lax Liquid Glycerin Suppositories, Sani-Supp, Fleet Glycerin Suppositories Pediatric

Professional resources

• Prescribing Information

Related treatment guides

• Constipation

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.04.

The Use of Glycerol Suppositories

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Questions and answers – Genferon Light suppositories

What are the fundamental differences between drops and suppositories containing interferon? Is the effect identical when using them?

Intranasal preparations of IFN α-2b have a predominantly local effect, limited mainly to the nasal mucosa. The systemic effect of intranasal agents is extremely insignificant. Interferon in the form of drops or spray fights ARVI pathogens directly in the primary focus of infection, preventing further massive penetration of viruses into the body. Also, intranasal agents have a local immunomodulatory effect, affecting immune factors and cells of the mucous membrane of the upper respiratory tract. The use of interferon-based intranasal agents is advisable for prophylactic purposes (for example, as a seasonal or post-exposure prophylaxis of influenza and SARS), as well as treatment for SARS limited to local symptoms (runny nose, nasal congestion, etc. ).

The use of suppositories provides a systemic effect of interferon. Being absorbed from the surface of the rectal mucosa and entering the general circulation, interferon alpha-2b has a systemic immunomodulatory effect and an antiviral effect on pathogens circulating in the blood. Thus, the use of interferon in the form of suppositories is advisable, incl. with SARS, accompanied not only by local symptoms, but also by general ones (weakness, malaise, fever, etc.).

Much is written that interferon is not absorbed by rectal administration, is this true?

With rectal administration of the suppository, there is a high bioavailability of interferon (more than 80%), in connection with which a pronounced systemic effect of the drug is ensured. The achievement of the maximum concentration of interferon alpha-2b in the blood serum with rectal administration of GENFERON ^® LIGHT 125 thousand IU candles is recorded already 5 hours after their application. In the study of Korsunsky V. N. the level of IFN-α in the blood after rectal administration was practically not inferior to the injection method of administration ¹ .

Korsunsky V.N. Bruskin A.B. Denisov L.A. Ivanov R.A. Comparative study of the pharmacokinetics of various dosage forms of interferon-alpha-2b // Effective pharmacotherapy. Obstetrics and Gynecology” No. 1. 2007.

Why do the manufacturers of different suppositories differ in the dosage of interferon? Is it true that a higher dosage can provide better results? alpha 2b in three dosages:

– 125,000 IU
– 150,000 IU
– 500 thousand IU.

The different content of the dose of interferon is largely due to the presence of additional components in the composition of a particular drug. The fact is that IFN α-2b can reduce its activity and even be destroyed in inflammatory foci under conditions of oxidative stress. To preserve the activity of interferon, some manufacturers include special antioxidant substances in the composition of the drug, which ensure the stability of the interferon molecule.

For example, in the composition of suppositories GENFERON ^® LITE 125 thousand IU, interferon protection is provided by TAURINE. The presence of TAURINE in the composition of suppositories GENFERON ^® LIGHT 125 thousand IU allows the use of a lower dosage of interferon alfa-2b without any loss in the therapeutic properties of the drug. According to the results of individual studies, this combination allows you to achieve even better therapeutic results in comparison with drugs containing higher doses of interferon.

So, in the studies of Gorelov A.V. et al. ^1.2 in children who were administered suppositories GENFERON ^® LITE 125 thousand IU, there was a lower incidence of nasal congestion, swelling of the tonsils, pathological discharge from the nose, symptoms of pharyngitis and tonsillitis compared with suppositories containing IFN α-2b in dose of 150 thousand IU. The frequency of disappearance of viruses during treatment was 33% higher in the group of patients treated with GENFERON ^® LIGHT suppositories 125 thousand IU

In another study ³ comparing suppositories GENFERON ^® LITE 125 thousand IU with suppositories containing interferon alfa-2b at a dosage of 500 thousand IU in combination with an immunoglobulin complex, therapeutic indicators of GENFERON ^{® 90 012 LITE 125 thousand IU was not only not inferior to the reference drug, but was accompanied by an even more pronounced tendency to stop inflammatory changes and intoxication phenomena, contributed to the rapid normalization of stool in patients with acute intestinal infections and reduced the need for infusion therapy.}

In addition, it is also important to note that a lower dosage of interferon alfa-2b helps to reduce the total interferon load and provides a more gentle attitude towards the baby’s body.

Gorelov A.V., Tselipanova E.E., Alimova I.L. The use of the drug GENFERON ^® LITE in children of different ages with ARVI. effective pharmacotherapy. 2016. No. 21. P. 12-16.

Gorelov A.V., Feklisova L.V., Gracheva N.M., Kanner E.V., Pogorelova O.O., Tselipanova E.E., She Yu.F., Chernyaeva E.V. Immunotropic therapy of acute respiratory viral infections in pediatric practice: experience in the clinical use of interferon-α preparations. Pediatrics. Supplement to Consilium Medicum. 2010. No. 1. S. 72-80.

Gorelov AV, Feklisova LV, Ploskireva AA, Meskina ER, Litvinchuk OA, Chernyaeva EV. Complex therapy of viral diarrhea in children – the first results of an open comparative randomized clinical trial of interferon preparations. Pediatric pharmacology. 2011;8(4):106-14.

What is the difference between GENFERON

^® LIGHT suppositories and preparations based on release-active components?

Preparations based on release-active components are immunomodulatory agents. The principle of their action is based on the stimulation of the child’s body to produce its own interferons. At the same time, the rate of production of endogenous interferons by the body, as well as the amount of interferon formed, is unpredictable, since it depends on the individual characteristics of the immune system – its current status and reactivity (ability to respond to external stimulation). Given the immature immune systems of young children, it is even more difficult to predict the effect of such drugs in infants and newborns.

Suppositories GENFERON ^® LITE 125 thousand IU contain a clearly adjusted dosage of ready-made interferon, which implements immunomodulatory and antiviral activities upon reaching peak blood concentrations. This allows you to optimize and reduce the time that the body can spend on the production of its own endogenous interferons. Rapid blocking of virus activity is the key to a less severe course of a cold and a factor that helps reduce the risk of developing complications of influenza and SARS.

What exactly is the difference between human and recombinant interferon? How exactly is it obtained? Could it affect genetics?

Human leukocyte interferon preparations are made directly from donated blood components. In their composition, these drugs are a mixture of interferon alpha-2b and other cytokine proteins produced by donor blood leukocytes in response to exposure to the virus. The composition of human leukocyte interferon preparations is not constant even from one manufacturer.

The disadvantages of IFN preparations derived from human blood, in addition to the heterogeneity of the composition, also include a low degree of purification, including from viral particles. In addition, human leukocyte IFN preparations cannot be used by injection (intramuscular or intravenous). Currently, leukocyte IFN preparations are used strictly for health reasons, when the expected benefits outweigh the possible risks.

Recombinant interferons are obtained using modern methods of biotechnology and genetic engineering. Synthesis of interferons is produced by special bacteria (E. coli) without the use of donor blood. Thus, an especially pure homogeneous recombinant IFN protein is obtained, identical to the human in amino acid composition. Domestic recombinant IFN alfa-2b was created in 1986–1990 Clinical trials and long-term experience of registered preparations based on recombinant IFN did not reveal significant side effects and contraindications for the use of preparations of recombinant IFN α-2b.

For the first time, the possibility of synthesizing drugs in E. Coli (E. coli) cells was demonstrated more than 40 years ago. In this way, such important drugs as somatostatin and human insulin were obtained. The beginning of the era of biopharmaceuticals can be considered 1982, when the industrial production of recombinant human insulin began. Today, the biopharmaceutical market includes hormones, interferons, interleukins, growth factors, tumor necrosis factors, blood coagulation factors, thrombolytic drugs, enzymes, monoclonal antibodies and vaccines. In addition, recombinant proteins are used to treat, prevent and diagnose various diseases, including: diabetes, multiple sclerosis, hepatitis B and C, anemia, thrombocytopenia, rheumatoid arthritis, Crohn’s disease, malignant neoplasms, etc.

Padkina M.V., Sambuk E.V. Genetically Modified Microorganisms as Producers of Biologically Active Compounds // Ecological Genetics. 2015. V. 13. No. 2. S. 36-57

Do drugs like GENFERON

^® LIGHT suppress the child’s own defenses with frequent use. Will the child’s body subsequently be able to produce interferon normally on its own?

The main stages of development and maturation of the immune system occur before about 5 years of age ⁶ . Children under the age of 5 years, especially in the period up to 2 years, are classified by the CDC and WHO as risk groups for the complicated course of infectious diseases (flu, infectious diarrhea).

Interferon deficiency is typical for young children. In the neonatal period, “early” IFN circulates in the blood of children, which has weak protective properties, unlike interferon-α in an adult ⁷ . In addition, in children under 1 year of age, the synthesis of IFN is reduced by 9 times compared with adults, in children under 3 years of age it is 6 times lower than in adults ⁷ . At an older age, the formation of interferon, as a rule, is reduced in frequently ill children (FIC) and in children with allergic diseases ^2.4 . In addition, viruses are capable of blocking the production of interferon-alpha in the human body ⁵ . IFN, which is also formed in the body during ARVI, is inactivated as a result of oxidative stress caused by inflammation ⁸ .

A decrease in the formation of interferon is fraught with a protracted and complicated course of infection ⁵ . Thus, interferon-alpha preparations play the role of replacement therapy for interferon deficiency.

Denisov LA, Sholokhov IV Discovery of interferon and its clinical application // Infectious Diseases. 2017, No. 1. S. 23–31.

Pugliese A, Salomone C, Martino S, Biglino A, Delpiano A, Tovo PA. Defective interferon-alpha production in children with recurrent respiratory tract infections. A primary or secondary deficiency? Boll East Sieroter Milan. 1985;64(4):328-31.

Vanĕcek K1, Lehovcová A, Hlousková Z. Deficiency of interferon production in children with recurrent respiratory diseases. Czech Med. 1990;13(2-3):64-70.

Edwards MR1, Regamey N, Vareille M, Kieninger E, Gupta A, Shoemark A, Saglani S, Sykes A, Macintyre J, Davies J, Bossley C, Bush A, Johnston SL. Impaired innate interferon induction in severe therapy resistant atopic asthmatic children. Mucosal Immunol. 2013 Jul;6(4):797-806.

Tregoning JS1, Schwarze J. Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev. Jan 2010;23(1):74-98.

Teran R1, Miter E, Vaca M, Erazo S, Oviedo G, Hübner MP, Chico ME, Mattapallil JJ, Bickle Q, Rodrigues LC, Cooper PJ. Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response. Clinic Immunol. 2011 Mar;138(3):299-310.

Zaitseva O.V. Infection and immunity: topical issues in pediatric practice. Children’s infections. 2015. V. 14. No. 1. S. 36-43.

Chebotareva T.A., Zaplatnikov A.L., Zakharova I.N., Vyzhlova E.N. Modern possibilities of interferon therapy for influenza and acute respiratory infections in children. Children’s infections. 2013. V. 12. No. 2. S. 35-38.

Can I use the drug in premature babies?

According to the order of the Ministry of Health of the Russian Federation dated 24.12. 2012 No. 1382n “On approval of the primary health care standard for the prevention of respiratory infections in premature infants”, the use of interferon α-2b with taurine is indicated for the prevention of respiratory infections in premature infants: Interferon alfa-2b + Taurine 250,000 IU / day 7 days (one suppository of 125 thousand IU twice a day with an interval of 12 hours)84 year. This treatment regimen has reduced mortality from neonatal sepsis by 15%. Malinovskaya V.V. studied the therapeutic efficacy of a similar antiviral drug based on interferon in the treatment of severe infections (intrauterine herpes, skin and generalized forms, congenital chlamydia, viral and bacterial pneumonia, meningitis of various etiologies, sepsis, severe forms of pyoinflammatory diseases, visceral candidiasis, mycoplasmosis, cytomegalovirus infection ). The test involved 460 newborns, including premature babies born earlier than 32 weeks (body weight 1421±218) and children born between 33 and 36 weeks of pregnancy (body weight 2086±385). The background conditions of children were edematous syndrome, hyperbilirubinemia, malnutrition, intrauterine growth retardation, hypoxic CNS damage.

Interferon therapy contributed to a more rapid elimination of the symptoms of infectious toxicosis, accelerated weight gain was observed, and improvement of laboratory diagnostic parameters. Against the background of therapy with antiviral immunostimulating drugs of interferon-α, cases of chronic infection and deaths were not recorded. Neurological and purulent-inflammatory complications were observed much less frequently than in the comparison group.

The inclusion of a course of interferon therapy in the complex of therapeutic measures for newborns and premature babies made it possible to reduce the intensity and duration of antibiotic therapy, hormone therapy, and the need for transfusion of blood products. Not a single case of interferon therapy was accompanied by the development of side effects, allergic reactions, or other complications. An analysis of the results of three-year observations did not reveal any differences in the health status of children treated with interferon from the standard indicators of their age group.

At the moment, a clinical study of the use of GENFERON ^® LITE 125 thousand IU in newborns, including those born at different stages of pregnancy, has been completed. The drug can be used in the treatment of various infectious and inflammatory diseases in newborns at a dose of 125,000 IU according to standard therapy regimens.

Optimization of the results of treatment of viral and bacterial infections in children: an algorithm for the use of Kipferon® suppositories | Feklisova L.V., Meskina E.R., Galkina L.A., Tselipanova E.E., Kazakova S.P., Savitskaya N.A.

Optimizing the results of treatment of viral and bacterial infections in children: an algorithm for the use of Kipferon® suppositories

06 April 2009

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• Feklisova L.V.

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• Meskina E.R.

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• Galkina L.A.

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• Tselipanova E. E.

  1

,

• Kazakova S.P.

,

• Savitskaya N.A.

1

GBUZ MO MONIKI them. M.F. Vladimirsky, Moscow, Russia

For citation: Feklisova L.V., Meskina E.R., Galkina L.A. Optimization of the results of treatment of viral and bacterial infections in children: an algorithm for the use of Kipferon® suppositories. breast cancer. 2009;7:468.

Infectious diseases are the most widespread pathology in childhood.