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Diphenhydramine (Benadryl) | Children’s Health Partners

Benadryl is useful for the relief of allergic symptoms, including nasal allergies and allergic rashes or hives (urticaria). It can also be used to prevent or treat motion sickness.

 

Benadryl frequently causes sleepiness as a side effect, but it can paradoxically cause excitation in young children. It is not recommended to use Benadryl solely for the purpose of sedating or making a child sleepy.

 

Please do not give Benadryl to a child under 6 months of age without first discussing it with our office.



Diphenhydramine (Benadryl) Dose Chart 



Benadryl can be dosed up to every 6-8 hours.
1 teaspoon = 5 mL
1/2 teaspoon = 2.5 mL













WeightMilligram DosageChildren’s liquid 12. 5mg/5mLChildren’s Allergy Strips 12.5mg each or Chewable tablet 12.5mg eachBenadryl Allergy Capsule or Tablet 25mg
11-16 lbs6.25mg2.5mL (1/2 tsp)N/AN/A
17-21 lbs9.375mg3.75mL (3/4 tsp)N/AN/A
22-27 lbs12.5mg5mL (1 tsp)1 tablet or stripN/A
28-32 lbs15.625mg6.25mL (1 1/4 tsp) N/A
33-38 lbs18.75mg7.5mL (1 1/2 tsp) N/A
39-43 lbs21.875mg8.75mL (1 3/4 tsp) N/A
44-54 lbs25mg10mL (2 tsp)2 tablets or strips1 tablet or capsule
55-65 lbs31. 25mg12.5mL (2 1/2 tsp)  
66-76 lbs37.5mg15mL (3 tsp)3 tablets or strips 
77-87 lbs43.75mg17.5mL (3 1/2 tsp)  
>87 lbs50mg20mL (4 tsp)4 tablets or strips2 tablets or capsules


Diphenhydramine (Benadryl)

Benadryl is useful for the relief of allergic symptoms, including nasal allergies and allergic rashes or hives (urticaria). It can also be used to prevent or treat motion sickness.

 

Benadryl frequently causes sleepiness as a side effect, but it can paradoxically cause excitation in young children. It is not recommended to use Benadryl solely for the purpose of sedating or making a child sleepy.

 

Please do not give Benadryl to a child under 6 months of age without first discussing it with our office.


Diphenhydramine (Benadryl) Dose Chart 


Benadryl can be dosed up to every 6-8 hours.

1 teaspoon = 5 mL

1/2 teaspoon = 2.5 mL


Benadryl Chldren’s Liquid 12.5mg/5mL    

  • 11-16 lbs – 2.5mL (1/2 tsp)
  • 17-21 lbs – 3.75mL (3/4 tsp)
  • 22-27 lbs – 5mL (3/4 tsp)
  • 28-32 lbs – 6.25mL (1 1/4 tsp)
  • 33-38 lbs – 7.5mL (1 1/2 tsp)
  • 39-43 lbs – 8.75mL (1 3/4 tsp)
  • 44-54 lbs – 10mL (2 tsp)
  • 55-65 lbs – 12. 5mL (2 1/2 tsp)
  • 66-76 lbs – 15mL (3 tsp)
  • 77-87 lbs – 17.5mL (3 1/2 tsp)
  • >87 lbs – 20mL (4 tsp)

Children’s Allergy Strips 12.5mg each or Chewable Tablet 12.5mg each

  • 22-27 lbs – 1 tablet or strip
  • 44-54 lbs – 2 tablets or strips
  • 66-76 lbs – 3 tablets or strips
  • >87 lbs –  4 tablets or strips

Benadryl Allergy Capsule or Tablet 25mg               

  • 44-54 lbs – 1 capsule or tablet
  • >87 lbs – 2 capsules or tablets

Amazon.com: Benadryl Ultratabs Go Packs, Antihistamine Tablets with Diphenhydramine HCl, 2 Count, Pack of 4 : Health & Household

Safety Information

Do not use

  • To make a child sleepy
  • With any other product containing diphenhydramine, even one used on skin

Ask a doctor before use if you have

  • A breathing problem such as emphysema or chronic bronchitis
  • Glaucoma
  • Trouble urinating due to an enlarged prostate gland

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizersWhen using this product

  • Marked drowsiness may occur
  • Avoid alcoholic drinks
  • Alcohol, sedatives, and tranquilizers may increase drowsiness
  • Be careful when driving a motor vehicle or operating machinery
  • Excitability may occur, especially in children

If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Ingredients

Active ingredient (in each tablet): Diphenhydramine HCl 25 mg (antihistamine) Inactive ingredients: Carnauba wax, croscarmellose sodium, D&C red no. 27 aluminum lake, dibasic calcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, titanium dioxide

Directions
  • Take every 4 to 6 hours, or as directed by a doctor
  • Do not take more than 6 times in 24 hours

Adults and children 12 years and over: 1 to 2 tabletsChildren 6 to under 12 years: 1 tabletChildren under 6 years: Do not useOther information

  • Each tablet contains: Calcium 15 mg
  • Store between 20-25°C (68-77°F). Protect from light.
  • Do not use if carton is opened or if blister unit is broken

Questions or comments? call 1-877-717-2824 (toll-free) or 215-273-8755 (collect)

Legal Disclaimer

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

What parents need to know the TikTok Benadryl Challenge

How can parents prevent their kids and teens from participating?

Teach kids who are old enough about proper medication use

Teens might think that because a medication is over-the-counter (OTC) that it is safe—but this is not always the case. Even though these medications can be sold without a prescription, they can be very dangerous when not taken properly.

Knowing these risks, parents may wonder: ‘Why would my child want to participate in this challenge?’

“What we are seeing is that kids are doing this as a dare, to fit in online or because their friends have done it—some of who have had no harm and some who have had significant harm to themselves,” said Marcy McCracken, a patient care manager at Children’s Minnesota. “There is a belief that it won’t kill you—that taking this medication will just give you a rush or a high.”

Talk to them

Use this as an opportunity to talk to your children about social media. Discuss the kind of content that they see on these platforms, and make sure to keep an open dialogue. Kids should feel comfortable talking to you about trends they see online, and should ask questions if they don’t understand what they are seeing.

If your teen is old enough to manage medications on their own, teach them how to read the label so they can understand what is an appropriate amount of an OTC medication to take. You can also look at the safety information together so they understand what can happen to them if they take too much of a medication.

Keep medications out of reach

If you are worried that your child will participate in a challenge like the Benadryl Challenge, keep medications that contain diphenhydramine locked up and out of reach. You can read the Drug Facts label on any OTC medication to find out if it contains diphenhydramine.

What to do if your child takes too much Benadryl

If your child has taken too much of a medication—whether it was Benadryl or a different medication—you should immediately contact poison control at 1-800-222-1222 or online, or seek medical attention.

Benadryl Allergy, 25 mg, Ultratabs – 24 tablet box

Benadryl Allergy, 25 mg, Ultratabs – 24 tablet box | Rite Aid

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From the Manufacturer

PRODUCT DETAILS

Item No. 0033202

Benadryl Allergy Ultratabs Antihistamine Allergy Relief Tablets offer effective allergy relief from hay fever, upper respiratory allergy and common cold symptoms in a small tablet size. Each antihistamine tablet contains 25 milligrams of the antihistamine diphenhydramine HCl to temporarily relieve allergy symptoms due to hay fever and upper respiratory allergies like sneezing; runny nose; itchy throat and nose; and itchy, watery eyes and the common cold symptoms of runny nose and sneezing. Benadryl Ultratabs with diphenhydramine HCl 25 mg are intended for adults and children ages six and up. The allergy tablets work when you need it most and provide multi-symptom indoor and outdoor allergy relief.

  • Benadryl Ultratabs Allergy Relief Tablets each with 25 mg of the antihistamine diphenhydramine HCl
  • Provides temporary allergy symptom relief for sneezing; runny nose; itchy nose or throat; and itchy, watery eyes
  • Provides relief of cold symptoms like sneezing & runny nose for more than just allergy relief
  • Allergy medicine suitable to treat adults and children ages 6 and up for multi-symptom allergy relief
  • Active ingredient, diphenhydramine HCl, provides effective relief for allergy symptoms and cold symptoms
  • Over-the-counter allergy medication is now available for FSA and HSA reimbursement without a prescription. For any questions you may have regarding FSAs or HSAs, please browse our FAQ.

MORE INFORMATION

More Information
Product NameBenadryl Ultratabs Antihistamine Allergy Medicine Tablets – 24 ct
Sub BrandBenadryl Ultra
Package Count24
Container Typebox
FormTablet
Strength (Medicine)25
Strength UOMmg
Country of ManufactureUnited States
Nutritional/Supplemental Facts

Total Fat 0g 0% 65g, Saturated Fat 0g 0% 20g, Trans Fat 0g, Cholesterol 0mg 0% 300mg, Sodium 0mg 0% 2400mg, Potassium 0mg 0% 3500mg, Total Carbohydrate 0g 0% 300g, Dietary Fiber 0g 0% 25g, Sugars 0g, Protein 0g, Vitamin A 0. 0%, Vitamin C 0.0%, Calcium

Best ForAllergies
Prop 65No

HOW TO USE

Take every 4 to 6 hours, or as directed by a doctor Do not take more than 6 times in 24 hoursAdults and children 12 years and over: 1 to 2 tabletsChildren 6 to under 12 years: 1 tabletChildren under 6 years: do not useOther information Each tablet contains: calcium 15 mg Store between 20-25C (68-77F). Protect from light.Questions or comments call 1-877-717-2824 (toll-free) or 215-273-8755 (collect)

INGREDIENTS

Active ingredient (in each tablet): Diphenhydramine HCl 25 mg (antihistamine)Inactive ingredients: Carnauba wax, croscarmellose sodium, D&C red no. 27 aluminum lake, dibasic calcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, titanium dioxide

SAFETY

Do not use
To make a child sleepy
With any other product containing diphenhydramine, even one used on skin
Ask a doctor before use if you have
A breathing problem such as emphysema or chronic bronchitis
Glaucoma
Trouble urinating due to an enlarged prostate gland
Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers

When using this product
Marked drowsiness may occur
Avoid alcoholic drinks
Alcohol, sedatives, and tranquilizers may increase drowsiness
Be careful when driving a motor vehicle or operating machinery
Excitability may occur, especially in children
If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

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Benadryl For Dogs: Dosage, Benefits, & Side Effects

If your dog suffers from allergies or has an allergy, the solution can be found in your medicine cabinet or your neighborhood drugstore. We’re talking about Benadryl. While other human drugs should NOT be used on our canine companions, Benadryl is safe to use with the right dosage.

What is Benadryl

Benadryl, also known by its active ingredient diphenhydramine, is an antihistamine that alleviates both human and dog allergy symptoms.

Benadryl has a variety of uses when it comes to your dog’s health. In this article, we explain how to give your dog Benadryl, the proper dosage according to body weight, and its potential side effects. We also have suggestions for natural alternatives to Benadryl.

Can I Give My Dog Benadryl? 

Yes, you can give your Benadryl safely to your dog. Veterinarians approve using Benadryl for dogs for a number of reasons. Antihistamines like Benadryl can help ease motion sickness, inflammatory and allergic reactions from insect bites and seasonal allergies.

Benadryl tablets work by blocking h2 receptors to keep histamines at bay, reducing symptoms of allergies. PetMD’s Doctor of Veterinary Medicine Jessica Vogelsang assures dog parents that the drug is “well tolerated and has a wide safety margin” for use on dogs.

Benadryl Usage for Dogs

Veterinarians recommend Benadryl – and its generic diphenhydramine – for dogs for a range of symptoms. These include environmental allergies, food allergies, anxiety, hives, motion sickness and more.

Because Benadryl can cause drowsiness, it is sometimes used for dogs with mild to moderate anxiety issues. Many dog parents give their dogs Benadryl during high-stress situations like thunderstorms or fireworks. Veterinarians will recommend its use in conjunction with heartworm treatment as it prevents allergic reactions associated with it. 

What Can Benadryl Treat In Dogs?

Benadryl is typically recommended by vets for dogs who are suffering from mild or moderate allergy symptoms. These allergies could be caused by seasonal allergies, environmental allergies such as grass, food allergies, or allergies that are caused by insect bites or snakes bikes. Similar to Claritin for dogs, Benadryl is commonly recommended for dogs who are sufferings from skin allergies and itchiness that is caused by this type of allergy reaction.

The most common symptoms that Benadryl can treat:

  • Itchy skin
  • Red or inflamed skin
  • Swelling and inflammation
  • Eye boogers or discharge buildup
  • Constant sneezing
  • Coughing or hacking
  • Runny nose or red eyes
  • Hives
  • Itchy or red ears

Recommended Benadryl Dosage for Dogs

Most drugstore diphenhydramine tablets, whether generic or brand name Benadryl, are 25 milligrams. As with any drug, the correct dosage of Benadryl for dogs depends on the dog’s weight.

Benadryl Dosage for Medium-to-Large Dogs

The standard dosage for a dog is 1 milligram per pound of body weight, so one tablet is perfect for a 25-pound dog. Veterinarians suggest giving a dose every 8-12 hours (about 2-3 times a day).

Benadryl Dosage for Small Dogs

Small dogs under 25 pounds can take the children’s formula of liquid Benadryl. Liquid children’s formula is easier for measuring the proper dosage for smaller dogs than the tablets. Stick to the children’s formula of liquid Benadryl as the adult version contains alcohol, which is toxic to dogs.

Benadryl Dosage Chart for Dogs

Guidelines For Benadryl For Dogs

Never give a dog too much Benadryl — an overdose is possible. Abuse of the drug can result in fatal diphenhydramine poisoning, so always consult your veterinarian if you are unsure of proper dosage. Signs of overdose include constipation, agitation, dilated pupils, seizures, and rapid heart rate.

If your dog is suffering from an onset of a severe allergic reaction, use your best judgment to determine if it would be best to opt for an emergency trip to your veterinarian. There are cases where a veterinarian may need to inject an antihistamine under your dog’s skin in order for the medicine to act more quickly.

Also, avoid using time-release capsules for dogs. Time release capsules are absorbed differently in humans vs dogs, and may affect your dog’s dosage.

Benadryl Side Effects in Dogs

Just like any medication, Benadryl comes with potential side effects. Common side effects of Benadryl include drowsiness, dry mouth, urinary retention, hypersalivation, increased heart rate, and loss of appetite for some dogs. The side effects of Benadryl for dogs are typically thought to be minor as the medication is widely recommended for dogs. If you are worried about adverse reactions when you are trying to relieve symptoms, it is recommended that you monitor your dogs behavior when you give Benadryl to your dog for the first time.

You can find some peace in knowing that most veterinary practices will recommend Benadryl as a safe option for environmental allergens and other issues commonly found in dogs. In order to avoid some of these side effects it is important to remember to administer the proper Benadryl dosage for your dog as recommended by your veterinarian. 

How Long Does It Take For Benadryl To Work In Dogs?

Benadryl or Diphenhydramine is typically thought to be a fast acting medication for dogs. You can expect it to take effect in 1 to 2 hours but often times it will begin to work in under an hour. It is important to understand that it doesn’t begin working immediately and that it will take roughly an hour to reach its maximum efficacy. If you are planning on giving your dog Benadryl prior to playing outside in long grass, you should try to time it correctly so that the benefits align with your trip outside.

When to Avoid Giving Your Dog Benadryl

Benadryl may negatively interact with other medications. Do not use Benadryl with any central nervous system depressants, or on a pet with high blood pressure, seizures, bladder issues, lung disease, or glaucoma. If your dog is having difficulty breathing or swelling in the facial area, take them to the vet ASAP. It is always important to monitor how your dog reacts to medicine or supplements to make sure that your dog is reacting well to the ingredients. This is especially important if your dog has a known health history or if it is the first time you are giving this medication to your dog.

Can I Give My Dog Liquid Benadryl?

Benadryl comes in different forms that range from pills, liquid, or even Benadryl treats specifically designed for dogs. When you are giving your dog this type of medication it is important to first speak with your vet. Your veterinarian will have a better undestanding of the current health of your dog and any possible issues. Your vet will give you a recommended dosage of Benadryl based on the overall weight of your dog. This dosage will be in milligrams (mg). Once you know how many milligrams you can give to your dog, you must look at the label of your Benadryl to understand how much to give to your dog.

Liquid Benadryl or tablets will both list how many milligrams are within one serving. You should use this number as a reference in order to give your dog the correct and safe amount.

Is Benadryl Safe For Dogs To Calm Them Down?

Many dog owners will use Benadryl to calm their dog down as it can make them slightly tired, but this isn’t what the medicine is designed for. Benadryl and antihistamine medications are used to help alleviate allergy symptoms and as a side effect can cause your dog to calm down and become tired. Dogs that are incredibly active, anxious, or stressed out might not see much impact from this type of medication as it isn’t designed to calm dogs down, it is designed to help with allergies.

You can speak with your veterinarian on other alternatives for calming your dog down or dealing with anxiety or stress symptoms for your dog.

Alternatives Of Benadryl For Dogs

Benadryl is not the only solution for treating your beloved pet’s condition. If you would rather not use over-the-counter drugs for your dog, there are natural alternatives for controlling allergy symptoms and motion sickness.

Benadryl overdose is not common in humans or dogs but it is important for dog owners to understand that even FDA approved liquid Benadryl medication can be dangerous if you don’t give your dog the appropriate dosage. It is safe for dogs as it is just a mild sedative that is known for improving allergy symptoms or treat insect stings, but with any dog medication you must be careful.

Other over the counter medications don’t have the same active ingredient as a Benadryl tablet or an antihistamine drug. The following natural remedies are great options for providing the same kind of relief you can get from Benadryl.

Quercetin

When it comes to allergy symptoms like itchy red eyes, inflammation, sneezing, and runny noses in dogs, turn to nature’s Benadryl: quercetin.

Quercetin is a flavonoid found in the peels of fruits and vegetables that contains anti-inflammatory, antioxidant, and anti-histamine properties. It is one of the most popular natural solutions that many dog owners and pet owners turn to when dealing with allergy symptoms. This is often recommended by dog owners who want to avoid the development of kidney disease in their elderly dogs. It is important to listen to veterinary advice on what is the best option for your dog.

To determine how much quercetin to give your dog, we’ll look at the recommended dosage for humans weighing 150 pounds: 1,000 milligrams. To convert this into the right dose for your dog, take your pet’s weight, multiply it by 1,000, then divide it by 150 to get the milligram dosage your pet needs. Viola! Quercetin occurs naturally in foods your dog can eat, too, like blueberries, strawberries, and spinach.

Fun fact for dog parents: Quercetin occurs naturally in red wine as well. Drink up and cheers to your health, bipeds!

CBD

CBD (cannabidol) is another natural alternative to Benadryl that is particularly great for dogs with adverse skin conditions. Yes, the word, “canna” is in “cannabidol,” but CBD has absolutely no THC (tetrahydrocannabinol) in it, or any psychoactive properties that get marijuana users high.

CBD for medicinal use is not derived from marijuana, but from agricultural hemp that possesses health benefits for humans and pets alike. Studies have shown that CBD can help relieve itchy and dry skin due to daily allergies or allergic reactions. It also works wonders for dogs that suffer from motion sickness and is worth giving a try before your next car ride with Fido. CBD comes in tablet form as well as oils, lotions, and balms that can be applied topically to the affected area.

All in all, CBD is a reliable natural solution for a variety of medical conditions in addition to symptoms of allergies. CBD is incredibly versatile and can also be used in dogs and people for medical conditions like anxiety, pain, nausea, and cancer.

Baking Soda

Need an easy and immediate solution for calming your dog’s red, itchy, and inflamed skin? Look no further than your kitchen. You can use it by making a paste or a spray solution. Make a paste by mixing baking soda with a little bit of water, then place it on the affected area for a few hours before washing off. To make a spray, use more water to baking soda, pour into a spray bottle, and shake before each use. If your dog is a licker, try covering the spot with a sock if it’s on their foot, or have them wear a cone while the paste treats the area. 

Dog Allergies: Causes and Treatment

Believe it or not, your dog’s allergy symptoms might be from the food they’re eating. The animal-based ingredients in dog food (beef, dairy, chicken, lamb, egg, pork, fish, and rabbit) are responsible for over 3 times as many food allergy cases as the plant-based ingredients. According to a study on PubMed.gov, after five weeks of their dog patients “starting an elimination diet, more than 80% of patients had achieved a remission of clinical signs of CAFR [Cutaneous Adverse Food Reactions].”

That means your dog’s allergies could be eliminated just by changing what they eat. So before you give your dog any Benadryl, consider switching their dog food. 86% of customers reported a positive health benefit for their dog after switching to Wild Earth dog food!

We have a number of reviews from customers whose dogs no longer suffer from chronic itching, licking, inflammation, or gastrointestinal problems because of switching to Wild Earth dog food. Check out one of them in the video below!

Ease Your Pup’s Allergy Symptoms With Benadryl

Benadryl is safe for your pet and will help with their allergies or other symptoms. If you are considering Benadryl for your dog, it is vital that you make sure to give them the right dose.

If you are wary of giving your dog Benadryl, you have options. Natural alternatives to Benadryl for alleviating your dog’s allergy symptoms include quercetin, CBD, and baking soda.

If you are still unsure about which method is best for you and your pet, consult your veterinarian.

Is Benadryl Addictive for Sleep?

Generally, addiction to Benadryl is possible. People primarily develop a psychological dependence on the drug, stemming from the idea and fear that they won’t be able to get to sleep without it, or remain asleep for the entire night. The fear becomes anxiety, and the sensation of relaxation initially felt when Benadryl is used allays that anxiety –perpetuating the cycle of misuse.

Over time, a person who takes Benadryl may find that the original dose may not be enough to help them fall asleep as quickly as before, or that they are waking during the night. This indicates that the body has become more tolerant of the drug and a dependency has formed. The person then takes more of the drug to achieve the desired effect of falling asleep, or duration and state of rest.

Misuse of Benadryl should not be taken lightly. As with any drug, there are complications and side effects that are caused by misuse. With Benadryl misuse, the side effects can include any of the following:

  • Anxiety
  • Sedation
  • Increased heart rate
  • Low blood pressure
  • Reduced ability to concentrate
  • Blurred vision
  • Dry mouth (leads to GERD or dental issues)
  • Nausea
  • Memory loss
  • Impaired coordination
  • Constipation
  • Difficulty urinating
  • Liver dysfunction
  • Seizure

Additionally, in the studyCumulative Use of Strong Anticholinergic Medications and Incident Dementia,” it is reported that there is evidence to support a connection between the long-term use of drugs like Benadryl and the increase of dementia and Alzheimer’s disease. According to the study’s author Dr. Shelly Gray, “We know that these medications may have an effect on memory, and we always assumed that these effects were reversible. We didn’t think these medications were changing the brain permanently. Our study does suggest a link between the highest use and increased dementia risk.”

Diphenhydramine: Uses, Interactions, Mechanism of Action

Summary

Diphenhydramine is a h2 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.

Brand Names

Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody’s PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Z-sleep, Zzzquil

Generic Name
Diphenhydramine
DrugBank Accession Number
DB01075
Background

Diphenhydramine – perhaps known most commonly as its brand name formulation Benadryl – is a first-generation h2 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes 9,10,11,17. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties 11,16. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine h2 receptors within the central nervous system 9,10,11,17,5. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed for use within many non-prescription over-the-counter sleep aids and cough-and-cold medications that have been marketed for “night time” use 9,12,13.

Diphenhydramine is also used in combination with 8-chlorotheophylline as the anti-nausea drug Dimenhydrinate where it is utilized primarily for its antagonism of h2 histamine receptors within the vestibular system 4.

Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid 3. As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Weight
Average: 255.3547
Monoisotopic: 255.162314299
Chemical Formula
C17H21NO
Synonyms
  • 2-(benzhydryloxy)-N,N-dimethylethylamine
  • 2-diphenylmethoxy-N,N-demthylethanamine
  • Difenhidramina
  • Diphenhydramine
  • Diphenhydraminum
  • N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine
  • O-benzhydryldimethylaminoethanol
  • α-(2-dimethylaminoethoxy)diphenylmethane
  • β-dimethylaminoethanol diphenylmethyl ether
  • β-dimethylaminoethyl benzhydryl ether
Indication

Diphenhydramine is a first-generation histamine h2 receptor antagonist (h2 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insomnia, pruritis, urticaria, insect bites/stings, allergic rashes, and nausea 9,10,11,17,5.

Additionally, when the use of oral diphenhydramine is impractical, there are also prescription-only formulations such as diphenhydramine injection products that are effective in adults and pediatric patients (other than premature infants and neonates) for:
i) the amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after acute allergic reaction symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated 16;
ii) the active treatment of motion sickness 16; and
iii) use in parkinsonism when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents 16.

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Pharmacodynamics

Diphenhydramine has anti-histaminic (h2-receptor), anti-emetic, anti-vertigo and sedative and hypnotic properties 12. The anti-histamine action occurs by blocking the spasmogenic and congestive effects of histamine by competing with histamine for h2 receptor sites on effector cells, preventing but not reversing responses mediated by histamine alone 12. Such receptor sites may be found in the gut, uterus, large blood vessels, bronchial muscles, and elsewhere 12. Anti-emetic action is by inhibition at the medullary chemoreceptor trigger zone 12. Anti-vertigo action is by a central antimuscarinic effect on the vestibular apparatus and the integrative vomiting center and medullary chemoreceptor trigger zone of the midbrain 12.

Mechanism of action

Diphenhydramine predominantly works via the antagonism of h2 (Histamine 1) receptors 9,10,11,17,5. Such h2 receptors are located on respiratory smooth muscles, vascular endothelial cells, the gastrointestinal tract (GIT), cardiac tissue, immune cells, the uterus, and the central nervous system (CNS) neurons 9,10,11,17,5. When the h2 receptor is stimulated in these tissues it produces a variety of actions including increased vascular permeability, promotion of vasodilation causing flushing, decreased atrioventricular (AV) node conduction time, stimulation of sensory nerves of airways producing coughing, smooth muscle contraction of bronchi and the GIT, and eosinophilic chemotaxis that promotes the allergic immune response 9,10,11,17,5.

Ultimately, diphenhydramine functions as an inverse agonist at h2 receptors, and subsequently reverses effects of histamine on capillaries, reducing allergic reaction symptoms 9,10,11,17,5. Moreover, since diphenhydramine is a first-generation antihistamine, it readily crosses the blood-brain barrier and inversely agonizes the h2 CNS receptors, resulting in drowsiness, and suppressing the medullary cough center 9,10,11,17,5.

Furthermore, h2 receptors are similar to muscarinic receptors 9,10,11,17,5. Consequently, diphenhydramine also acts as an antimuscarinic 9,10,11,17,5. It does so by behaving as a competitive antagonist of muscarinic acetylcholine receptors, resulting in its use as an antiparkinson medication 9,10,11,17,5.

Lastly, diphenhydramine has also demonstrated activity as an intracellular sodium channel blocker, resulting in possible local anesthetic properties 9.

Absorption

Diphenhydramine is quickly absorbed after oral administration with maximum activity occurring in approximately one hour 6,13. The oral bioavailability of diphenhydramine has been documented in the range of 40% to 60%, and peak plasma concentration occurs about 2 to 3 hours after administration 6,13.

Volume of distribution

Diphenhydramine is widely distributed throughout the body, including the CNS 18. Following a 50 mg oral dose of diphenhydramine, the volume of distribution is in the range of 3.3 – 6.8 l/kg 18.

Protein binding

Some prescribing information records the protein binding of diphenhydramine as approximately 78% 18 while others have suggested the medication is about 80 to 85% 13 bound to plasma proteins.

Metabolism

Diphenhydramine undergoes rapid and extensive first-pass metabolism 18,13,8. In particular, two successive N-demethylations occur wherein diphenhydramine is demethylated to N-desmethyldiphenhydramine (the N-desmethyl metabolite) and then this metabolite is itself demethylated to N,N-didesmethyldiphenhydramine (the N,N-didesmethyl metabolite) 18,8. Subsequently, acetyl metabolites like N-acetyl-N-desmethyldiphenhydramine are generated via the amine moiety of the N,N-didesmethyl metabolite 8. Additionally, the N,N-didesmethyl metabolite also undergoes some oxidation to generate the diphenylmethoxyacetic acid metabolite as well 18,13,8. The remaining percentage of a dose of administered diphenhydramine is excreted unchanged 18,13,8. The metabolites are further conjugated with glycine and glutamine and excreted in urine 13.

Moreover, studies have determined that a variety of cytochrome P450 isoenzymes are involved in the N-demethylation that characterizes the primary metabolic pathway of diphenhydramine, including CYP2D6, CYP1A2, CYP2C9, and CYP2C19 7. In particular, CYP2D6 demonstrates higher affinity catalysis with the diphenhydramine substrate than the other isoenzymes identified 7. Consequently, inducers or inhibitors of these such CYP enzymes may potentially affect the serum concentration and incidence and/or severity of adverse effects associated with exposure to diphenhydramine 7.

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Route of elimination

The metabolites of diphenhydramine are conjugated with glycine and glutamine and excreted in urine 12,13. Only about 1% of a single dose is excreted unchanged in urine 12,13. The medication is ultimately eliminated by the kidneys slowly, mainly as inactive metabolites 12,13.

Half-life

The elimination half-life ranges from 2.4-9.3 hours in healthy adults 18,13. The terminal elimination half-life is prolonged in liver cirrhosis 13.

Clearance

Values for plasma clearance of a 50 mg oral dose of diphenhydramine has been documented as lying in the range of 600-1300 ml/min 18.

Adverse Effects

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Toxicity

Overdose is expected to result in effects similar to the adverse effects that are ordinarily associated with the use of diphenhydramine, including drowsiness, hyperpyrexia, and anticholinergic effects, among others 10,11,12,13,18. Additional symptoms during overdose may include mydriasis, fever, flushing, agitation, tremor, dystonic reactions, hallucinations and ECG changes 13. Large overdose may cause rhabdomyolysis, convulsions, delirium, toxic psychosis, arrhythmias, coma and cardiovascular collapse 13. Moreover, with higher doses, and particularly in children, symptoms of CNS excitation including hallucinations and convulsions may appear; with massive doses, coma or cardiovascular collapse may follow 18.

Although diphenhydramine has been in widespread use for many years without ill consequence, it is known to cross the placenta and has been detected in breast milk 18. This medication should therefore only be used when the potential benefit of treatment to the mother exceeds any possible hazards to the developing fetus or suckling infant 18.

Pharmacokinetic studies indicate no major differences in the distribution or elimination of diphenhydramine compared to younger adults 18. Nevertheless, diphenhydramine should be used with caution in the elderly, who are more likely to experience adverse effects 13. Avoid use in elderly patients with confusion 13.

The results of a review on the use of diphenhydramine in renal failure suggest that in moderate to severe renal failure, the dose interval should be extended by a period dependent on Glomerular filtration rate (GFR) 18.

After intravenous administration of 0.8 mg/kg diphenhydramine, a prolonged half-life was noted in patients with chronic liver disease which correlated with the severity of the disease 18. However, the mean plasma clearance and apparent volume of distribution were not significantly affected 18.

LD50=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

Pathways
Pharmacogenomic Effects/ADRs
Not Available

90,000 Is Benadryl safe to take while breastfeeding?

It is considered safe to take Benadryl ™ while breastfeeding at normal doses, although it is best for mothers to consult a healthcare professional before use. The manufacturer makes mistakes with caution and recommends that women avoid taking medications while breastfeeding, as they are excreted in breast milk, and newborns are especially sensitive to the effects of antihistamines.Research has shown, however, that the effects on infants do not appear in most cases or are usually quite moderate. Taking Benadryl ™ while breastfeeding may have unwanted side effects for mothers such as decreased breast milk and drowsiness.

Since it is an antihistamine, many women want to take Benadryl ™ to control their allergies. It blocks the action of histamine in the body and is used to treat allergy symptoms such as runny nose, sneezing, and watery eyes.Some may use it as a sleep aid. Women who are breastfeeding should consult a doctor before using Benadryl ™ or the generic form, diphenhydramine. In some cases, doctors may recommend using other allergy medications, such as fexofenadine or loratadine, which are usually milder in terms of side effects.

In general, taking Benadryl ™ while breastfeeding is considered safe at low doses or occasional use, as only a small amount passes into breast milk.Research shows that with minimal use, babies experience virtually no effects from Benadryl ™ in breast milk. However, some side effects can affect breastfed babies when mothers take high doses or take the drug for a long time. Exposure to the child includes irritability, colic, and drowsiness.

Although it is generally safe for women to take Benadryl ™ while breastfeeding, there are side effects that can interfere with breastfeeding. Benadryl ™ can reduce the supply of breast milk, especially during the early postpartum period when breastfeeding is not established. High doses of the drug can lower the levels of the hormone prolactin, which is required for the production of breast milk. Women can prevent this by taking one dose of the drug at night after the last breastfeeding session during the day. Once breastfeeding is well developed, this side effect diminishes because suckling in infants ensures a stable supply of milk.

In addition, there are several other side effects on mothers that can occur when taking Benadryl ™ while breastfeeding. Women may feel very drowsy or dizzy. It can also cause headaches, dry mouth, and difficulty urinating. If side effects become unpleasant or interfere with breastfeeding, women should consider switching to another type of antihistamine.

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90,000 Benadryl vs Claritin for allergies: differences and side effects

Are Benadryl and Claritin the same thing?

Benadryl (diphenhydramine) and Claritin (loratadine) are antihistamines used to treat allergy symptoms such as itching, hives, runny nose, watery eyes, and sneezing from hay fever (allergic rhinitis) and other allergies such as allergy to mold and dust mites.

Benadryl is also used to treat insomnia, motion sickness, and mild cases of parkinsonism.

The main difference between Benadryl and Claritin is that Claritin causes less sleepiness and less sedation than Benadryl.

Benadryl and Claritin are available in generic and over-the-counter (OTC) form.

What are the possible side effects of Benadryl?

What is retina A used for

Benadryl side effects include:

  • drowsiness,
  • fatigue,
  • fatigue,
  • drowsiness,
  • dizziness,
  • impaired coordination,
  • constipation,
  • dry mouth / nose / throat,
  • labored urination or an enlarged prostate,
  • indigestion,
  • blurred vision,
  • double vision,
  • tremors,
  • loss of appetite,
  • headache, or
  • nausea.

What are the possible side effects of claritin?

Common side effects of Claritin include:

  • Headache,
  • drowsiness,
  • feeling tired,
  • drowsiness,
  • fatigue,
  • nervousness,
  • abdominal pain,
  • diarrhea,
  • mouth,
  • sore throat,
  • hoarseness,
  • eye redness,
  • blurred vision,
  • nosebleed, or
  • skin rash.

Tell your doctor if you experience any serious side effects of Claritin, including a fast or uneven heartbeat, feeling like you might pass out, jaundice (yellowing of the skin or eyes), or seizures (convulsions).

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What is Benadryl?

Benadryl (diphenhydramine) is an antihistamine used to treat allergies, urticaria, insomnia, motion sickness, and mild cases of parkinsonism.

What is Claritin?

What is Claritin?

Claritin (loratadine) is an antihistamine used to treat allergy symptoms.Claritin blocks the action of histamine, a substance in the body that causes allergic symptoms such as itching, sneezing, runny nose, and allergic skin rashes. Claritin is available as a generic drug.

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What medications interact with Benadryl?

Benadryl may interact with other medicines that cause drowsiness (such as medicines for colds or allergies, sedatives, narcotic pain medicines, sleeping pills, muscle relaxants, and medicines for seizures, depression, or anxiety).

Benadryl may also interact with monoamine oxidase inhibitors (MAOIs).

What medications interact with claritin?

Claritin interacts with various medications. Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter medicines for coughs, colds, allergies, or insomnia, medicines for anxiety or sleep, antidepressants, or any other medicine that causes drowsiness, drowsiness, or relaxation.

Claritin may interact with some antibiotics, antifungal and acid-lowering drugs.

How should I take Benadryl?

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The typical dose of Benadryl is 25-50 mg every 4-6 hours. Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter medicines for coughs, colds, allergies, or insomnia, medicines for anxiety or sleep, antidepressants, or any other medicine that causes drowsiness, drowsiness, or relaxation.Tell your doctor about all medications and supplements you are taking. Benadryl has not been adequately evaluated in pregnant women. Benadryl is excreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature babies, breastfeeding mothers should not use antihistamines.

How should I take Claritin?

Claritin is available as 10 mg tablets, 5 or 10 mg fast disintegrating tablets, 10 mg chewable tablets and syrup (5 mg per 5 ml).Claritin is taken 1 time per day.

Disclaimer

All drug information presented on RxList.com is derived directly from drug monographs published by the US Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug use, dosage, etc., taken from the original drug records contained in its FDA drug monograph.

The drug information contained in drug comparisons published on RxList.com is primarily derived from FDA drug information. The drug comparison information contained in this article does not include data from human or animal clinical trials conducted by any of the drug comparison drug manufacturers.

The medication comparison information provided does not cover all potential uses, warnings, drug interactions, side effects, side effects or allergic reactions.RxList.com is not responsible for the medical care provided to a person based on the information posted on this site.

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Because drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the fact that medication information is time-dependent, RxList.com makes no guarantees that the information provided is the most up-to-date.

The absence of drug warnings or information in no way guarantees the safety, efficacy, or side effects of any medication. The medication information provided is for reference only and cannot be used as a substitute for medical advice.

If you have specific questions regarding drug safety, side effects, uses, warnings, etc., you should ask your doctor or pharmacist or consult the details of specific drugs that can be found on the FDA websites …gov or RxList.com for more information. …

You can also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or by calling 1-800-FDA-1088.

Recommendations Medical Editor: John P. Cunha, DO, FACOEP

SOURCE:

RxList. Benadryl Medication Guide.

https://www.rxlist.com/benadryl-drug.htm#medguide

RxList. Claritin Side Effects Center.

https://www.rxlist.com/claritin-side-effects-drug-center.htm

Russia will ban the challenge on TikTok: all because of the drug

In Russia, some videos on TikTok will be blocked. This applies to videos with the hashtag #benadryl. In fact, this inscription is not as harmless as it seems. The authors of the videos urge people to take the drug for allergies in large quantities in order to cause hallucinations. We are talking about a challenge in which you do not need to participate.

Roskomnadzor will be responsible for blocking content on the TikTok social network in Russia. This happened after it became known that in the United States, teenagers launched a challenge, the essence of which is to take high doses of an allergy drug called Benadryl to induce hallucinations. Boris Mendelevich, a member of the State Duma Health Protection Committee, asked the department to remove this kind of content from the Russian Internet if possible.

Roskomnadzor responded to Mendelevich’s appeal, found 20 channels on TikTok, where videos of this content are posted.If the department finds more videos, it will block them too.

Not only Mendelevich and Roskomnadzor considered the content dangerous, but also Rosmolodezh. “Video recordings on the above links pose a threat to the life and health of minors,” the organization said in a letter, RIA Novosti reports.

Crazy Challenge

Tiktokers named the challenge #Benadryl. As part of this competition, users drink large amounts of the allergy medicine Benadryl to induce hallucinations.Videos with the hashtag #Benadryl on TikTok gained about 5.5 million views at the end of July, and by the end of August the number of users interested in this topic had grown to six million.

“After taking Benadryl, I see people in my room”

This challenge really has negative consequences. At least three teenagers were sent to the hospital in May. Everyone ended up at Cook Children’s Medical Center. The doctors of the institution emphasized that Benadryl is a dangerous drug, an overdose of which is dangerous and can even lead to death.This is despite the fact that the drug is sold for some reason without a prescription.

“Excessive amounts of diphenhydramine (the active ingredient is Benadryl – ed.) Can cause heart palpitations and arrhythmias, as well as hallucinations and convulsions. In addition, overdose can cause urinary retention, so a urinary catheter may be required for treatment, ”said Nurse Amber Jevison.

Among the victims of “Benadryl” was 14-year-old blogger Rebecca. She took 14 tablets of the drug.The girl developed hallucinations, her speech became abrupt, and her pulse rose to 199 beats per minute (at a rate of 65 to 90).

Someone even thought of giving a drug to a dog. And this effect followed five minutes later.

Benadryl has a list of side effects due to a substance called diphenhydramine. In addition to a crazy increase in heart rate, the drug causes difficulty urinating, uncontrolled movement of the tongue, swelling of the face, lips, throat, difficulty breathing, confusion, dizziness, drowsiness (due to the effect on the central nervous system), loss of coordination, dry mouth, indigestion, dry eyes, blurred vision, feeling of a hangover.And this is only a part of those negative phenomena that may arise when taking Benadryl.

Zyrtec VS Claritin: which is better for allergies?

Many people use antihistamines to treat allergy symptoms: Zyrtec and Claritin are two of the most popular brands, but which is better?

Both are considered safe and effective treatments for minor allergies. Both are second generation antihistamines and cause less sleepiness than first generation antihistamines.No study has shown Zyrtec and Claritin to be the most effective, although some people report positive results. Small differences between the two may make one drug more suitable for some people.

Antihistamines may reduce allergy symptoms such as watery eyes, itchy skin, hives, and swelling. They can also help with dermatitis or even mosquito bites, but are usually sold for certain types of allergies.

Zyrtec and Claritin are in the same class of drugs and tend to work the same in the body.Both drugs can be bought over-the-counter at pharmacies and are available in a variety of forms, including tablets, chewable tablets, and syrups.

Active Ingredients

Zyrtec and Claritin have different active compounds. The first one contains cetirizine hydrochloride, also called cetirizine HCL, while “Claritin” contains loratadine.

Drugs are less likely to make a person feel sleepy or affect alertness than older first generation antihistamines.However, “Zyrtec” still tends to cause drowsiness more than “Claritin”.

Marking “Zyrtec” states that a person should not accept it when driving a vehicle or using equipment. Also, avoid taking it with alcohol or other medications that may make you drowsy.

Time frame

Zyrtec and Claritin are effective for about 24 hours. They should only be taken once a day. The body absorbs antihistamines quickly, but Zyrtec seems to work faster for some people.

A 2014 study showed that both drugs were absorbed into the bloodstream within 1-2 hours after ingestion. Other studies show that most people respond to Zyrtec within an hour, while Claritin may take 1-3 hours.

Comparison with other medicines for allergy treatment

Researchers often study, compare and improve antihistamines. Other popular products are Allegra and Benadryl:

– Allegra contains the active ingredient fexofenadine.The drug makes the person feel sleepy;

– Benadryl contains the active ingredient diphenhydramine. It works faster than any of the previously described drugs and is intended to treat minor skin reactions rather than seasonal allergies. Benadryl is a sedative antihistamine, so people tend to feel drowsy after taking it.

How do allergy medications work?

When a person comes in contact with an allergen, their immune system reacts and produces a chemical called histamine.It causes many allergy symptoms, including skin or sinus inflammation, pain, redness, and hoarseness. Immune responses also contribute to the development of extra mucus.

Allergy drugs block histamine responses – this reduces the body’s response to minor or harmless allergens such as pollen, dust and pet hair.

Warnings

Zyrtec and Claritin are considered extremely effective and safe for most people with minor allergies, however, as with all medications, there are some potential side effects.

Loratadine may be safe for people with severe liver conditions, which must destroy loratadine, while cetirizine is excreted in the urine largely unchanged.

Claritin interacts more often with other drugs than Zyrtec. Claritin is broken down in the liver by enzymes that can inhibit other drugs, which can increase the risk of side effects.

pixabay.com

Everyone responds differently to drugs, but Zyrtec and Claritin are associated with the following potential side effects:

– drowsiness, which is more likely with Zyrtec;

– headache;

– dizziness;

– sore throat;

– dry mouth;

– constipation or diarrhea;

– abdominal cramps;

– redness of the eyes.

Some people experience a severe allergic response called anaphylaxis after taking antihistamines. Seek emergency medical attention if any of the following symptoms are present:

– urticaria;

– swollen throat;

– swollen lips or face;

– shortness of breath or other respiratory symptoms;

– heart palpitations.

pixabay.com

Some antihistamines are safe for children, but it is recommended that you discuss with your doctor or check the label carefully before giving antihistamines to your child.

A 2012 review found that the use of antihistamines during pregnancy can be problematic. Many studies have confirmed the safety of first generation antihistamines, but less is known about the effects of second generation brands such as Zyrtec and Claritin on fetal development. While the UK’s National Health Service states that loratadine and cetirizine should be safe to use during pregnancy, it is best to see your doctor when considering using any antihistamine.

Clinical Study Breast Cancer: TPI 287, Dexamethasone, Benadryl, Ranitidine – Clinical Trials Registry

Detailed Description

Investigational drug: TPI-287 is designed to prevent cancer cell division, which can slow and / or stop cancer cell growth. Investigational Drug Administration: If it is determined that you are eligible for this study, you will receive TPI 287 by veins.more than 60 minutes per day 1 of each 21-day cycle. You will receive oral dexamethasone, Benadryl, before you take the study drug. (diphenhydramine hydrochloride) by vein for 30-60 minutes and ranitidine for 30-60 minutes to help prevent a potential serious allergic reaction. Study visits: During all study visits, you will be asked about any side effects you may have and any other medications you may be taking. On days 1, 8 and 15 of cycle 1 blood (about 2-3 teaspoons) will be drawn for routine tests.If you are taking Coumadin, blood will be drawn (about 1-2 teaspoons) to check how well you are clotting. On Day 1 of Cycle 1, your performance status and vital signs will be recorded. measured. Within 7 days after Day 1 of the 2nd cycle and further: – Blood (about 2-3 tablespoons) will be taken for routine tests. If you are taking Coumadin, blood (about 1 to 2 teaspoons) will be drawn to check how well your blood clots. – You will undergo a physical examination, including a measurement of your weight and vital signs.- Your performance status will be recorded. – You will have a neurological examination. Every 6 weeks (that is, before every odd cycle): – You may have a CT scan or MRI of the chest, abdomen and pelvis to check the status. illness. – You will have an MRI of your brain. For an MRI, you will need to insert a catheter into one of your veins to inject MRI contrast. A researcher and staff will look at your images to determine at what stage the tumor is inside and / or outside your brain.Duration of Study: You can keep getting TPI 287 for as long as the doctor thinks it is at its best. interest. You will no longer be able to get TPI 287 if the illness gets worse, if intolerable side effects occur, or if you are unable to follow the directions in the study. Your participation in the study will end at the end of your treatment. and follow-up visits. End of Treatment Visit: Approximately 4 weeks after stopping TPI 287: – You will have a physical examination, including vital signs.- You will have a neurological examination. – Your performance status will be measured. – Blood (about 2 tablespoons) will be taken for routine tests. – You will have a CT and / or MRI to check the status of the disease. This may include an MRI of the brain. If your doctor deems it necessary, you will have a bone scan. – You will be asked about any side effects you may have from the medications you are taking. Follow-up visits: Upon graduation, you will be contacted either at the clinic or by telephone every 3 months.within 1 year of your participation in the study to check your health. If you receive a call, it will take no more than 5 minutes. This is an exploratory study. TPI 287 is not FDA approved and is not marketed. This time TPI 287 is used for research purposes only. The study will involve up to 69 patients. Everyone will be enrolled in MD Anderson.

90,000 “This drug has crippled my life.” Why a prescription drug in Belarus was dispensed without a prescription

To buy a drug with the active ingredient “flupirtine maleate”, you do not need to be an adult or know special phone numbers – until recently, anelgesic drug with this substance was dispensed in Minsk without a prescription.It is so common that there is a video on Youtube describing the “trips” below it. KYKY publishes the story of a girl who violated the indications for use and became addicted to him. Now she has undergone rehabilitation, but addiction is a chronic disease that cannot be cured.

Editor’s note: the pharmacists with whom the author spoke, say that the last drug with this substance was withdrawn from Belarusian pharmacies last week. At the same time, pharmacists of Minsk pharmacies admit that until last week it was released without a prescription and to any clients over 16, because it was not listed in their databases as a prescription.The story of the heroine of this material tells about obvious violations of the drug intake as a medicine. But this does not mean that no one does that.

Seven years on one preparation

“He came into my life when I was 16 years old. An ex-boyfriend brought it to me to try. He said that this pain reliever is a cool thing that gives pleasure. When I tried it for the first time, I felt intense euphoria. In my head there were many thoughts in general about everything. The most varied, interesting ones, I wanted to record them.He also acts like an energetic: he constantly wants to move under him. If I didn’t have the strength or I had doubts, was worried about doing something or meeting with someone, he helped me. Of course, more than one pill helps. Moreover, over the years, its effect has changed. Then everyone in Minsk said that they urgently needed to buy, because they were about to start selling only by prescription. But that never happened.

At first there were small doses to feel something good. I could have blisters at home for months.Then I had to eat more and more often. For a while I was able to leave him, but after a couple of years he came back into my life. By the age of 18, I began to eat once every two weeks – on weekends, at parties. When bad things began to happen in my life: breakups, problems with studies, a bad climate in the family – that was my help. He helped me cope with this crazy world. I was never afraid of pills as I grew up in a family of people who worked for a pharmaceutical company. I trusted pills more than people, because they always work, and they work quickly.It was an easy and enjoyable way that didn’t bring anything bad into your life.

But I started to use it more and more often. The years passed. There were addicts: there were two people next to me who led me to constant use, increasing my doses. Then they left my life, but my addiction not only remained, but increased. I don’t blame anyone for this, it’s my responsibility. I only blame those who should have made it a prescription. There were times when I was furious talking to the pharmacists who sold it to me.Told them that they were hooked on him – this is not normal. She said that he makes people dependent, although the instructions say that there can be no dependence on him. And they just shrugged their shoulders, they say, whoever wants to, he sits, but someone buys and uses as it should, – no.

On this topic: What are we being treated with? How and why HIV therapy in Belarus has tripled in price

By the age of 18, I ate about three times a week on a full blister, and by 23 – already ten pieces a day. I was very afraid then for my health, for my liver, I went to the doctors.They found nothing, of course. But the drug has a strong effect on the brain, and I can feel it on myself. Brain cells die off. I forgot a lot, even absolutely elementary words. Began to get confused in numbers, in time. You turn into an old granny so confused with Alzheimer’s. And this is very frightening.

I have had cases of complete amnesia. Once I was going to a party, I ate about 10 pieces. I left the house with friends who wanted to give me a ride there. And I woke up in my apartment at seven o’clock in the morning because the dress cut my neck.It’s so scary not to remember anything! I only remembered that I never got to the party. Then I cried a lot, because it’s scary. I’d like to know what happened. Once I fell asleep in my parents’ apartment with the music on. The phone rang a thousand times. The doorbell rang. But I didn’t hear anything, and my sister had to call a burglar.

At the age of 18-19, due to a serious misunderstanding in the relationship, it hurt me a lot. I was at a party on pills. And you know, it’s disgusting: I couldn’t walk, but I tried.I fell, people fell because of me, because my body rocked in a wave from one wall of the club to another. In use, you come to arrogance: you say what is not worth saying. The next day you wake up and think: “God, why did I say that?” But most importantly, the drug is deceiving. You think about one thing, you do it, and then you wake up and regret it, because you really didn’t want it. Brains think very differently. Your reputation is undermined, people perceive you differently. After that incident in the club, the security guard told me: “One more time – and not once.”Fortunately, this was no longer the case.

Once I was alone in the office. I had the keys to close it. But I was so stupid that I just did not understand how to close it. I did not understand where the keys were, what was wrong with them. I kind of close but nothing closes. I call my married colleague at midnight, even his wife speaks to me. I sob. I understand that I closed it with the wrong keys. I find those, close them and then it dawns on me: I closed the roller shutter, which I cannot lift, but inside I forgot the keys to the house. I spent the night on the street.She knelt down on October Square in front of the Palace, roared and promised myself that this would never happen again. This “never again” happened many times. It crashes everything, crashed my life by six months of daily use.

I lost my job, lost myself, because by the end I stopped recognizing myself. I didn’t want to go to rehab at all, but now I don’t regret it. She was my last chance, before her I tried to be treated with two psychotherapists and with medication.I was prescribed antidepressants that turned me into a vegetable and I could only watch TV shows all day. But as soon as the psychiatrist canceled one of the two drugs, I fell out again. In the end, I decided to go to rehab – and it was cool. By the way, that psychotherapist said that he knows a little about this drug, they say, this is now a new trend. There are a lot of people in Minsk who sit on it, they just have not yet reached the point of being treated.

From the last six months before rehabilitation, I do not remember a lot, and I am offended for that.I am very glad that my loved ones stayed with me. When I was in rehab, very many had no one. They were very scared to leave the walls of the hospital, to come back here and be alone. I am ashamed of many things in front of my family, but we are doing the best we can after the hospital.

What I dislike about this substance is its easy availability. You can buy over-the-counter at the pharmacy 24 hours a day. And in Minsk there are many pharmacies – I constantly see these green crosses. And it’s cheap. It is not in Russia.But in Minsk a lot of people are sitting on it, and they no longer like it. We thought all the time that there would be a recipe. This summer I met a man at the pharmacy who was also queuing up for blisters. He was not in that pharmacy and we ran to another. We bought it.
“They’ll write a prescription in August,” he told me.
– Are you glad about that?
– I’m extremely happy about that.

On this topic: The Pill of Happiness. Is it possible to become yourself with the help of psychotropics

I was waiting for August, but, unfortunately, there is still no recipe. “

Pharmacist Comment

Artemiy is a pharmacist in a Minsk pharmacy, but due to the closed nature of the healthcare sector in our country and the experience of being fired due to public comments, he agreed to comment anonymously: “Of these harsh drugs without a prescription, only one remained. We have codeine-containing drugs on prescription. Well, there are also tinctures: valocordin and everything that contains phenobarbital. By the way, last week it was withdrawn from all pharmacies – we even received a letter. I don’t know the reasons, maybe they want to change something at last.I heard a version that some drug therapists themselves prescribe it to patients who are sitting on a heavy weight in order to transplant with tramadol, because it is without a prescription and it is easy to get it.

As for drugs that should be transferred to the prescription category, these are definitely drugs with phenobarbital: valocordin and barboval. They are highly addictive when using overdoses. In Lithuania, for example, valokordin is made by prescription; Lithuanians are bought here in packs. Fortunately, we have codeine preparations on prescription, because in Ukraine it is sold without a prescription – and this is horror.After all, this is a derivative of opiates, and from it “crocodile” (aka desomorphine) is brewed – an artisanal drug that belongs to synthetic opiates. Compared to morphine, it is more likely to cause persistent dependence: somewhere after two intravenous injections. Moreover, mental dependence develops faster than physical one. Already after the first injection, there is a strong desire to repeat the experienced sensations. In addition, it is cheaper to prepare, so it began to be used as an alternative to heroin. In the mid-2000s, there was a boom in Russia.Well, it is called “crocodile” because ulcers appear at the injection site, covered with a purulent crust – it resembles the skin of a crocodile. In terms of the degree of harm to health, “crocodile” is several times superior to heroin. That is why it is called the drug of suicide.

What does prescription leave depend on? There is a regulation on dispensing drugs without a prescription – an over-the-counter list. Automatically everything that is not included will be sold by prescription. There are enough legal problems, and every five years a special commission revises the list of OTC drugs.But in special cases, they can make amendments by a special letter, for example, if a fatal outcome occurs due to side effects. ”

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Is it safe to take Benadryl while breastfeeding? – Healths

What is Benadryl? What are the ingredients of Benadryl? Is Benadryl safe to take while breastfeeding? Can Benadryl cause side effects in babies? What are the alternatives to Benadryl? Benad

Contents

  • What is Benadryl?
  • What are the ingredients of Benadryl?
  • Is Benadryl safe to use while breastfeeding?
  • Can Benadryl cause side effects in babies?
  • Are there alternatives to Benadryl?

Benadryl is widely used to treat coughs and sometimes as an antihistamine to relieve skin irritation.However, it has mild sedative properties and can pass into breast milk that a baby receives.

Read this MomJunction post to find out if Benadryl is safe to breastfeed, its ingredients and possible side effects.

What is Benadryl?

Benadryl is an OTC brand of drugs sold to treat a variety of conditions, from coughs to skin allergies. It is available in topical and oral forms.Topical Benadryl is used to treat skin allergy symptoms such as skin rashes and itching. Oral Benadryl is available as capsules, chewable tablets and syrup, which are used to treat symptoms of colds, coughs and allergies such as runny nose, itchy throat, etc.

A variant of Benadryl syrup is also used specifically for cough relief and sore throat relief.

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What are the ingredients of Benadryl?

The main active ingredient in most Benadryl products is Diphenhydramine .It belongs to a class of compounds called antihistamines that are used to relieve a wide range of allergy symptoms (1Trusted). Antihistamines work by blocking the action of histamine, a molecule in the body responsible for allergy symptoms.

The body absorbs diphenhydramine from Benadryl through the skin or stomach, depending on the route of administration. The blood carries diphenhydramine to various parts of the body, including breast tissue, from where it can pass into breast milk.

[Read: Can I take cold medicine while breastfeeding? ]

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Is Benadryl safe to take while breastfeeding?

Yes, but here’s something you need to know before using Benadryl while breastfeeding.

  1. Single dose is safe: A single dose of Benadryl, such as before bedtime and after the last feed of the day, is unlikely to cause any problems for the baby (2).Diphenhydramine is one of the older or first generation antihistamines that rarely cause serious health problems in infants, especially in minimal doses and irregular doses (3).
  1. May affect when the lactation period is not set: Medical experts state that the dose of diphenhydramine can cause problems for the baby and mother if the lactation period is not set (4). It takes about 4-6 weeks for the baby and the mother’s body to get used to breastfeeding (5).Therefore, it is best not to take Benadryl unless your baby is 4-6 weeks old. However, the appropriate age may vary and it is best to consult your doctor before taking medication.
  1. Combination with certain medications may cause problems: If you are taking any other medications, do not take Benadryl without consulting your doctor. Diphenhydramine from Benadryl can react with compounds in other medicines, causing side effects.For example, a class of drugs called sympathomimetic drugs can react with antihistamines, resulting in complications for the health of the mother and baby (2).
  1. Repeated doses may cause side effects with long-term use: Like any medicine, high doses of Benadryl and prolonged / regular use cause side effects in infants. The mother may also experience side effects such as decreased breast milk production.

Benadryl can indeed cause side effects in babies and it is very important to know all about it.

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Can Benadryl cause side effects in babies?

Yes. The following are the possible side effects of Maternal Benadryl on a nursing baby.

  1. Irritability and Colic: In a study of first generation antihistamines, researchers found that about 10% of mothers taking antihistamines reported colic and irritability in their babies.The exact dosage of the antihistamine is unknown, as is the duration of the side effect. However, none of the side effects required medical attention and the child remained healthy.
  1. Drowsiness: A study reported drowsiness in 1 of 12 infants whose mothers received diphenhydramine. The side effects were not serious. However, you should monitor your baby for signs of sleepiness, as diphenhydramine is known to induce sleep (6Trusted).

[Read: Is it safe to take ibuprofen while breastfeeding? ]

Always consult your doctor before taking any medication while breastfeeding with your baby’s health in mind. The compounds in Benadryl can interact with some other medicines you may be taking.

Also, talk with your doctor about using alternatives to Benadryl.

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What are the alternatives to Benadryl?

Alternatives to Benadryl differ depending on why you are taking this medication.Here are some child-safe Benadryl substitutes:

  1. Loratadine medicine: Loratadine is a medicine that helps relieve allergy symptoms. The dosage for the mother does not cause any problems in the nursing infant (7). In any case, the lowest dose of the medication is recommended. Also, like diphenhydramine from Benadryl, you should avoid taking the medication in combination with sympathomimetic drugs such as pseudoephedrine.
  1. Acetaminophen and ibuprofen: These drugs are among the safest for breastfeeding mothers and their babies (8) and can be used to reduce irritation associated with sore throat, fever and colds.Even when the maternal dose is higher than usual, the amount that passes into breast milk is much less (9) (10).
  1. Home Remedies: Instead of using Benadryl to treat your cough, you can use home remedies such as a mixture of ginger and honey, gargle with warm water, and warm broth / soup. Skin irritation can be reduced by using aloe vera gel and keeping the skin hydrated. Talk with your doctor about the right medications and lifestyle changes to help you feel better without taking medication.

Benadryl has been a popular drug for decades due to its widespread use. But when you are breastfeeding, consulting a doctor, using alternative medications, and a limited dose of Benadryl can help keep your nursing baby safe.