What are the common side effects of indapamide. How should indapamide be used properly. What precautions should be taken when using indapamide. What dietary instructions should be followed while taking indapamide. How to store and dispose of indapamide safely.

Common Side Effects of Indapamide: What to Expect

Indapamide, a diuretic medication commonly prescribed for hypertension and fluid retention, can cause several side effects in some patients. While these effects are generally mild, it’s crucial to be aware of them:

• Mild skin rash
• Nausea and vomiting
• Dizziness or feeling faint

These side effects occur in more than 1 in 100 people taking indapamide. However, there are ways to manage these symptoms effectively:

Managing Mild Skin Rash

If you develop a mild skin rash while taking indapamide, it’s important to consult your doctor promptly. They may need to adjust your treatment plan or recommend alternative medications.

Coping with Nausea and Vomiting

To alleviate nausea and vomiting associated with indapamide:

• Take the medication after meals
• Opt for simple, bland foods
• Avoid rich or spicy meals
• Stay hydrated by sipping water or squash frequently

If nausea persists for more than a week or you’re unable to drink properly, consult your doctor. For women taking contraceptive pills, be aware that vomiting may reduce the pill’s effectiveness.

Dealing with Dizziness

When experiencing dizziness:

• Sit or lie down until you feel better
• If dizziness occurs while standing, lie down to prevent fainting
• Avoid driving, cycling, or operating machinery while feeling dizzy

Serious Side Effects of Indapamide: When to Seek Medical Attention

While rare, indapamide can cause serious side effects in less than 1 in 1,000 people. It’s crucial to recognize these symptoms and seek immediate medical attention if they occur:

• Irregular heartbeat (arrhythmia)
• Severe, sudden stomach pain accompanied by nausea, vomiting, diarrhea, and fever (potential signs of pancreatitis)
• Yellowing of eyes or skin, dark urine, pale stools, fatigue, and loss of appetite (possible indicators of liver disease)

In extremely rare cases, indapamide may cause a severe allergic reaction (anaphylaxis). Symptoms of anaphylaxis include sudden swelling of lips, mouth, throat, or tongue, difficulty breathing, and skin discoloration. If you experience these symptoms, call emergency services immediately.

Long-Term Use of Indapamide: Monitoring and Precautions

Patients taking indapamide for extended periods require regular medical check-ups. These visits typically involve:

• Blood pressure measurements
• Blood tests to check electrolyte balance (calcium, sodium, and potassium)
• Urine tests to assess kidney function

The frequency of these tests depends on various factors, including the reason for taking indapamide, recent dose changes, side effects experienced, and other health conditions or medications.

Proper Usage of Indapamide: Dosage and Administration

Indapamide is typically prescribed as a once-daily medication. To ensure optimal effectiveness and minimize side effects:

• Take indapamide at the same time each day
• Swallow the tablet whole with water
• Do not crush, chew, or break the tablet
• If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose

Never double your dose to make up for a missed one. If you’re unsure about the correct dosage or administration, consult your healthcare provider or pharmacist.

Dietary Considerations While Taking Indapamide

While taking indapamide, it’s important to be mindful of your diet. Consider the following dietary guidelines:

• Limit alcohol consumption, as it can increase the risk of dehydration
• Avoid excessive salt intake, which can interfere with the medication’s effectiveness
• Maintain a balanced diet rich in potassium, unless otherwise advised by your doctor
• Stay well-hydrated, but avoid overhydration

Your healthcare provider may recommend specific dietary modifications based on your individual health status and needs.

Indapamide Interactions: Medications and Substances to Avoid

Indapamide can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. Be cautious with:

• Other diuretics or blood pressure medications
• Certain antidepressants
• NSAIDs (non-steroidal anti-inflammatory drugs)
• Lithium
• Digoxin

Always inform your healthcare provider about all medications, supplements, and herbal products you’re taking to avoid potential interactions.

Storage and Disposal of Indapamide: Best Practices

Proper storage and disposal of indapamide are crucial for maintaining its effectiveness and ensuring safety:

• Store at room temperature, away from moisture and direct sunlight
• Keep out of reach of children and pets
• Do not use expired medication
• Dispose of unused or expired indapamide properly, following local guidelines or pharmacy take-back programs

Never flush medications down the toilet or throw them in the trash unless specifically instructed to do so.

Pregnancy and Breastfeeding: Indapamide Considerations

If you’re pregnant, planning to become pregnant, or breastfeeding, it’s essential to discuss the use of indapamide with your healthcare provider. The medication’s effects on fetal development and infant health are not fully understood, and alternative treatments may be recommended.

In some cases, the benefits of using indapamide during pregnancy or breastfeeding may outweigh the potential risks. Your doctor will carefully weigh these factors to make the best decision for your health and that of your baby.

Pregnancy Categories

The FDA classifies indapamide as a Category B drug for pregnancy, meaning that animal studies have not shown a risk to the fetus, but there are no adequate studies in pregnant women. However, this classification system has been phased out, and healthcare providers now consider multiple factors when prescribing medications during pregnancy.

Breastfeeding Considerations

Limited data suggest that small amounts of indapamide may pass into breast milk. While the effects on nursing infants are not well-established, it’s crucial to discuss the potential risks and benefits with your healthcare provider if you’re breastfeeding or planning to breastfeed while taking indapamide.

Indapamide and Elderly Patients: Special Considerations

Elderly patients may be more susceptible to certain side effects of indapamide, particularly those related to electrolyte imbalances and dehydration. Healthcare providers often take extra precautions when prescribing indapamide to older adults:

• Starting with lower doses and gradually increasing as needed
• More frequent monitoring of kidney function and electrolyte levels
• Careful assessment of other medications that may interact with indapamide
• Educating patients and caregivers about signs of dehydration and electrolyte imbalance

Elderly patients taking indapamide should be particularly vigilant about staying hydrated and reporting any unusual symptoms to their healthcare provider promptly.

Indapamide in Combination Therapy: Enhancing Hypertension Treatment

Indapamide is often used in combination with other antihypertensive medications to achieve better blood pressure control. Common combination therapies include:

• Indapamide with ACE inhibitors
• Indapamide with angiotensin receptor blockers (ARBs)
• Indapamide with calcium channel blockers

These combinations can offer synergistic effects, allowing for lower doses of individual medications and potentially reducing side effects. However, combination therapy requires careful monitoring and adjustment by healthcare providers to ensure optimal efficacy and safety.

Benefits of Combination Therapy

Combining indapamide with other antihypertensive medications can provide several advantages:

• Improved blood pressure control
• Lower doses of individual medications, potentially reducing side effects
• Complementary mechanisms of action
• Potential for better long-term cardiovascular outcomes

Your healthcare provider will determine the most appropriate combination based on your individual health status, blood pressure goals, and potential side effects or contraindications.

Monitoring Kidney Function and Electrolyte Balance with Indapamide

Regular monitoring of kidney function and electrolyte balance is crucial for patients taking indapamide, especially those on long-term therapy or with pre-existing kidney issues. Healthcare providers typically assess:

• Serum creatinine levels
• Estimated glomerular filtration rate (eGFR)
• Serum potassium, sodium, and magnesium levels
• Uric acid levels

The frequency of these tests may vary depending on individual risk factors and response to treatment. Patients should be aware of signs that may indicate electrolyte imbalances or kidney problems, such as:

• Unusual fatigue or weakness
• Muscle cramps or twitches
• Irregular heartbeat
• Changes in urination patterns

Prompt reporting of these symptoms to healthcare providers can help prevent serious complications and ensure optimal management of indapamide therapy.

Indapamide and Metabolic Effects: Understanding the Impact

While indapamide is generally considered metabolically neutral compared to some other diuretics, it can still have effects on metabolism that warrant attention:

• Glucose metabolism: Indapamide may have a slight impact on glucose levels, particularly in patients with diabetes or pre-diabetes.
• Lipid profile: Some studies suggest that indapamide has a neutral or slightly positive effect on lipid profiles.
• Uric acid levels: Indapamide can increase uric acid levels in some patients, potentially exacerbating gout in susceptible individuals.

Healthcare providers often monitor these parameters, especially in patients with pre-existing metabolic conditions or those at high risk for developing such conditions.

Managing Metabolic Effects

To mitigate potential metabolic effects of indapamide:

• Regular monitoring of blood glucose, lipid profiles, and uric acid levels
• Dietary modifications as recommended by healthcare providers
• Consideration of alternative medications or combination therapies if significant metabolic effects occur
• Patient education about signs and symptoms of metabolic disturbances

By addressing these aspects, healthcare providers can optimize the benefits of indapamide while minimizing potential metabolic complications.

Indapamide in Specific Patient Populations: Tailoring Treatment

While indapamide is widely used for hypertension and fluid retention, its use may require special considerations in certain patient populations:

Patients with Liver Disease

Indapamide is metabolized in the liver, so patients with liver disease may require dose adjustments or more frequent monitoring. In severe liver disease, alternative medications may be preferred.

Patients with Diabetes

Indapamide’s effect on glucose metabolism necessitates careful monitoring in diabetic patients. Regular blood glucose checks and potential adjustments to diabetes medications may be required.

Patients with Gout

Due to its potential to increase uric acid levels, indapamide should be used cautiously in patients with a history of gout. Alternative diuretics or additional medications to manage uric acid levels may be considered.

Patients with Systolic Hypertension

Indapamide has shown particular efficacy in managing isolated systolic hypertension, common in elderly patients. It may be a preferred option for this specific type of hypertension.

Tailoring indapamide treatment to these specific patient populations requires a comprehensive understanding of the patient’s overall health status, comorbidities, and potential drug interactions. Healthcare providers must carefully weigh the benefits and risks of indapamide therapy in each individual case to ensure optimal outcomes and patient safety.

Side effects of indapamide – NHS

Common side effects

These common side effects of indapamide happen in more than 1 in 100 people. There are things you can do to help cope with them:

Mild skin rash

If you get a mild rash, speak to your doctor for advice as your treatment may need to be changed.

Feeling or being sick (nausea or vomiting)

Try taking indapamide after a meal. Try to stick to simple foods and avoid rich or spicy meals. Drink water or squash in small, frequent sips so you do not get dehydrated.

Speak to your doctor if you feel sick or are being sick frequently, or are unable to drink properly for more than a week.

If you take contraceptive pills and you’re being sick (vomit) your contraception may not protect you from pregnancy. Look on the pill packet to find out what to do.

Feeling dizzy or faint

Try sitting or lying down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Do not drive, ride a bike or use tools or machinery while you’re feeling dizzy.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Serious side effects

Serious side effects are usually rare and happen in less than 1 in 1,000 people.

Tell your doctor or call 111 straight away if you:

• get an irregular heartbeat (arrhythmia)
• get a severe stomach pain that develops suddenly, along with feeling or being sick, diarrhoea, indigestion, a high temperature, and tenderness or swelling of your stomach – these could be signs of pancreatitis
• feel or start being sick, get yellow eyes or skin, although this may be less obvious on brown or black skin, have dark pee, pale poo, tiredness and loss of appetite – these could be signs of liver disease

Serious allergic reaction

In rare cases, indapamide may cause a serious allergic reaction (anaphylaxis).

Immediate action required: Call 999 now if:

• your lips, mouth, throat or tongue suddenly become swollen
• you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
• your throat feels tight or you’re struggling to swallow
• your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• you suddenly become very confused, drowsy or dizzy
• someone faints and cannot be woken up
• a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Long-term side effects

If you are taking indapamide for a long time, you will occasionally have to see your doctor or nurse to get your blood pressure checked and have blood and urine tests. This is to make sure the salts (calcium, sodium and potassium) in your blood are balanced properly and your kidneys are working well.

How often you’ll need these tests will depend on the reason you’re taking indapamide, whether your dose has changed recently, whether you get side effects from indapamide, or if you have any other health problems or are taking other medicines.

Other side effects

These are not all the side effects of indapamide. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 4 March 2022

Next review due: 4 March 2025

Indapamide: MedlinePlus Drug Information

pronounced as (in dap’ a mide)

To use the sharing features on this page, please enable JavaScript.

Indapamide, a ‘water pill,’ is used to reduce the swelling and fluid retention caused by heart disease. It also is used to treat high blood pressure. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.

This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Indapamide comes as a tablet to take by mouth. It usually is taken once a day, in the morning. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take indapamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Indapamide controls high blood pressure but does not cure it. Continue to take indapamide even if you feel well. Do not stop taking indapamide without talking to your doctor.

Indapamide also is used to treat swelling and fluid retention caused by various medical conditions other than heart disease. Talk to your doctor about the possible risks of using this medicine for your condition.

Before taking indapamide,

• tell your doctor and pharmacist if you are allergic to indapamide, sulfa drugs, or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medications for high blood pressure, corticosteroids (e.g., prednisone), digoxin (Lanoxin), indomethacin (Indocin), lithium (Eskalith, Lithobid), probenecid (Benemid), and vitamins.
• tell your doctor if you have or have ever had heart rhythm problems, diabetes, gout, or kidney, liver, thyroid, or parathyroid disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking indapamide, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking indapamide.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
• remember that alcohol can add to the drowsiness caused by this drug.

Follow your doctor’s directions. They may include a daily exercise program and a low-sodium or low-salt diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Frequent urination may last for up to 6 hours after a dose and should decrease after you take indapamide for a few weeks. Tell your doctor if any of these symptoms are severe or do not go away:

• muscle cramps
• drowsiness
• dizziness
• confusion
• thirst
• upset stomach
• vomiting
• stomach cramps
• decreased sexual ability
• blurred vision

If you have any of the following symptoms, call your doctor immediately:

• rapid, excessive weight loss
• severe skin rash with itching
• difficulty breathing or swallowing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Lozol^®¶

^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 10/15/2017

Browse Drugs and Medicines

What helps, side effects, contraindications

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. number 31917

All authors

Contents of the article

• Indapamide: dosage
• Indapamide: mechanism of action
• Indapamide: before meals or after meals
• Indapamide: how long can you take it without interruption
• Indapamide: contraindications
• Indapamide: side effects for women
• Indap or Indapamide: which is better
• Summary
• Ask an expert on the topic of the article

Diuretics are medicines with a diuretic effect. Diuretic drugs began to be used for long-term treatment of arterial hypertension in the late 1950s. Medicines from the group of thiazide diuretics are prescribed for the treatment of hypertension in patients with osteoporosis. Often osteoporosis occurs in women during menopause. In this case, drugs of the thiazide group are the drugs of choice in the treatment of arterial hypertension in combination with osteoporosis.

Let’s talk about one of the drugs, its use – Indapamide.

Indapamide: dosage

Preparation with the same active ingredient.

Indapamide is available in two strengths – Indapamide 2.5 mg and Indapamide retard 1.5 mg. The prefix retard means that the drug is of moderate strength and long duration.

All products Indapamide

12 reviews

Indapamide: mechanism of action

The drug belongs to sulfonamide derivatives, inhibits the absorption of sodium ions in the kidneys. This increases the release of sodium, potassium, magnesium and chlorine ions, which leads to an increase in the volume of urine formed over a certain period of time. Does indapamide help with pressure? Yes, the drug has a hypotensive effect by improving the elastic properties of the arteries and reducing vascular resistance.

Indapamide before meals or after meals

Indapamide tablets can be taken with or without food, preferably in the morning.

Indapamide: how long can I take it without interruption

Can I take Indapamide continuously? To treat hypertension, doctors prescribe Indapamide to be taken on a regular basis. If within 4-8 weeks there is no desired therapeutic effect, it is necessary to tell the doctor about it.

Indapamide: contraindications

The drug has the following contraindications:

• individual intolerance to the drug components
• renal insufficiency
• liver disorders
• hypokalemia
• galactose and lactase intolerance, glucose-galactose malabsorption
• pregnancy and lactation
• children under 18 years of age

Indapamide: side effects for women

Patients most often report such adverse reactions as:

• allergic rash
• abdominal and chest pain
• edema
• constipation, nausea, diarrhea
• cough, pharyngitis, sinusitis

Seek medical attention if adverse reactions occur.

Indap or Indapamide: which is better

The drugs have identical active ingredients. Accordingly, the pharmacological action, contraindications and side effects are similar.

Indapamide and Indap are available in tablets and capsules.

Indap is produced in the Czech Republic, Indapamide is produced by many Russian manufacturers.

It is impossible to draw a conclusion about which drug is better. The drug can be selected from your own preferences and pricing policy.

All products Indap

10 reviews

Summary

• Indapamide is produced in two dosages – Indapamide 2.5 mg and Indapamide retard 1.5 mg.
• The drug belongs to sulfonamide derivatives, inhibits the absorption of sodium ions in the kidneys.
• Indapamide tablets can be taken with or without food, preferably in the morning.
• To treat hypertension, doctors prescribe Indapamide to be taken on a regular basis.
• The drug has contraindications.
• Seek medical attention if adverse reactions occur.
• Indap is produced in the Czech Republic, Indapamide is produced by many Russian manufacturers.

Ask an expert about Article

Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.

Editor-in-chief

Zotina Natalya Igorevna,

Expert pharmacist

Share mega-advice

Like the article? Tell mom, dad, grandmother and aunt Galya from the third entrance

Copy link

Indapamide: instruction, price, analogues | Hemofarm 9 film-coated tablets0001

• Pharmacological properties
• Indications Indapamide
• Application of Indapamide
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Storage conditions
• Diagnosis
• Recommended alternatives
• Trade names

indapamide ((RS)-4-chloro-3-sulfamol-N-(2-methyl-2,3 dihydro-1H-indol-1-yl)benzamide) is a diuretic, antihypertensive agent of the group of nonthiazide sulfonamides. Indapamide causes a decrease in the tone of the smooth muscles of the arteries due to a change in the transmembrane current of calcium ions, a decrease in the sensitivity of the vascular wall to noradrenaline and angiotensin, which leads to a decrease in OPSS. Indapamide stimulates the synthesis of prostaglandin E ₂ , which has a vasodilating and hypotensive effect. It exhibits a moderately pronounced diuretic effect, which is associated with blocking the reabsorption of sodium, chlorine, water and, to a lesser extent, potassium and magnesium ions. Indapamide does not disrupt lipid metabolism and does not adversely affect carbohydrate metabolism, does not affect the level of total cholesterol and TG, and reduces the level of phosphates in the blood serum. The therapeutic effect develops after 7-8 days, the maximum effect – after 4 weeks.

After oral administration, indapamide is rapidly absorbed, the maximum serum concentration is reached after 2-2.5 hours and is 230-260 ng / ml. Approximately 71-79% of indapamide binds to plasma proteins, mainly to α ₁ -glycoprotein. Widely distributed in body tissues. The half-life is 14 hours. It is metabolized in the liver. It is excreted in the urine (7% – unchanged for 48 hours, 70% – in the form of metabolites) and bile (about 23%).

Mild to moderate hypertension.

adults – 2.5 mg 1 time per day, preferably in the morning. In case of insufficient hypotensive effect, the dose is increased to 5 mg per day (in one dose in the morning). Increasing the dose of the drug enhances the diuretic effect.

hypersensitivity to indapamide and other components of the drug, as well as to sulfonamides, acute cerebrovascular accidents, hyperaldosteronism, severe liver and kidney dysfunction, hypokalemia.

headache, fatigue, convulsions, diarrhea, skin rash, frequent urination, in isolated cases orthostatic hypotension.

with are prescribed with special care to patients with impaired liver and kidney function. During treatment with the drug, periodic monitoring of the level of electrolytes in the blood serum is necessary due to the possibility of developing hypokalemia and disturbed water and electrolyte balance. Patients with hyperuricemia and gout who use indapamide need periodic monitoring of the level of uric acid in the blood serum.

During treatment with the drug, clinical manifestations of latent diabetes mellitus, as well as a change in the need for insulin, are possible. By lowering blood pressure, the drug may affect the ability to drive vehicles and mechanisms. Indapamide should not be prescribed during pregnancy and lactation.

it is possible to potentiate the action of other antihypertensive agents when used simultaneously with Indapamide. Do not prescribe simultaneously with lithium preparations, as this increases the risk of developing the toxic effects of the latter (due to a decrease in the renal clearance of lithium and an increase in its concentration in the blood plasma).