What are the potential interactions of Benadryl with other medications. How does Benadryl interact with alcohol and certain medical conditions. What precautions should be taken when using Benadryl.

Overview of Benadryl and Its Interactions

Benadryl, also known by its generic name diphenhydramine, is a widely used antihistamine medication. While effective for treating allergies and cold symptoms, it’s crucial to understand its potential interactions with other substances and medical conditions. This comprehensive guide explores the various interactions associated with Benadryl to ensure its safe and effective use.

Key Interaction Statistics

• Total drug interactions: 433
• Major interactions: 14
• Moderate interactions: 417
• Minor interactions: 2
• Alcohol/food interactions: 1
• Disease interactions: 8

Drug Interactions with Benadryl

Benadryl has a significant number of drug interactions, ranging from major to minor. Understanding these interactions is crucial for patient safety and optimal treatment outcomes.

Major Drug Interactions

Major interactions are considered highly clinically significant and should be avoided due to the potential risks outweighing the benefits. While the specific drugs causing major interactions with Benadryl are not listed in the provided information, it’s important to consult with a healthcare provider about any medications you’re currently taking before using Benadryl.

Moderate Drug Interactions

The majority of Benadryl’s drug interactions fall into the moderate category. These interactions are moderately clinically significant and usually should be avoided unless specifically approved by a healthcare provider. Some common medications that may have moderate interactions with Benadryl include:

• Acetaminophen
• Albuterol
• Amlodipine
• Aspirin
• Atorvastatin
• Clonazepam
• Gabapentin
• Ibuprofen
• Levothyroxine
• Lisinopril
• Metformin
• Prednisone
• Tramadol
• Trazodone

This list is not exhaustive, and it’s essential to check with a healthcare provider or pharmacist for a complete list of potential interactions with your specific medications.

Minor Drug Interactions

Minor interactions with Benadryl are considered minimally clinically significant. While the risk should be minimized, these interactions generally don’t require avoiding the combination altogether. However, it’s still important to be aware of them and monitor for any adverse effects.

Benadryl and Alcohol Interaction

Benadryl has one known alcohol/food interaction that warrants caution. The combination of Benadryl and alcohol can intensify the sedative effects of both substances, potentially leading to increased drowsiness and dizziness.

Precautions When Combining Benadryl and Alcohol

• Use alcohol cautiously when taking Benadryl
• Avoid exceeding recommended dosages of Benadryl
• Refrain from activities requiring mental alertness
• Consult a healthcare provider for potential dose adjustments if both substances are prescribed together

Can Benadryl and alcohol be used together safely? While it’s best to avoid combining Benadryl and alcohol, if you must use both, do so with extreme caution and under the guidance of a healthcare professional. The combination can significantly impair cognitive and motor functions, potentially leading to dangerous situations.

Disease Interactions with Benadryl

Benadryl has known interactions with several medical conditions. These interactions can affect the medication’s efficacy or potentially exacerbate certain health issues.

List of Disease Interactions

1. Depression
2. Anticholinergic effects
3. Asthma/COPD
4. Cardiovascular conditions
5. Renal/liver disease
6. Glaucoma
7. Liver disease
8. Respiratory depression

How do these disease interactions affect Benadryl usage? The presence of these conditions may require dosage adjustments, additional monitoring, or in some cases, the use of alternative medications. For instance, individuals with asthma or COPD may need to exercise caution due to Benadryl’s potential to thicken bronchial secretions. Similarly, those with liver or kidney disease may metabolize the drug differently, necessitating dose modifications.

Commonly Checked Drug Interactions with Benadryl

While Benadryl interacts with numerous medications, some are more frequently checked due to their common usage or potential for significant interactions.

Frequently Checked Interactions

• Claritin (loratadine)
• Flonase (fluticasone nasal)
• Singulair (montelukast)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Why are these interactions frequently checked? Many of these medications are commonly used for similar conditions as Benadryl or are widely used supplements. For example, interactions with other antihistamines like Claritin or Zyrtec are often checked to avoid doubling up on similar medications. Similarly, interactions with commonly used pain relievers like Tylenol or anxiety medications like Xanax are important to monitor due to potential additive sedative effects.

Understanding Drug Interaction Classifications

Drug interactions are classified based on their clinical significance and the potential risks associated with combining medications. These classifications help healthcare providers and patients make informed decisions about medication use.

Classification Categories

• Major: Highly clinically significant. Combinations should be avoided as the risk outweighs the benefit.
• Moderate: Moderately clinically significant. Usually avoid combinations; use only under special circumstances.
• Minor: Minimally clinically significant. Minimize risk; consider alternatives or implement monitoring plans.
• Unknown: No interaction information available.

How should these classifications guide medication use? While these classifications provide valuable guidance, they are not absolute rules. The relevance of a particular drug interaction can vary between individuals. Always consult with a healthcare provider to determine the appropriate course of action based on your specific medical history and current medications.

Importance of Healthcare Provider Consultation

Given the complexity of drug interactions and individual variations in response to medications, consulting with healthcare providers is crucial for safe and effective use of Benadryl.

Key Reasons to Consult Healthcare Providers

• Personalized assessment of potential interactions
• Guidance on proper dosage and timing of medications
• Monitoring for potential side effects or adverse reactions
• Recommendations for alternative treatments if necessary
• Adjustments to treatment plans based on individual health status

How can patients effectively communicate with their healthcare providers about medication interactions? Maintain an up-to-date list of all medications, including over-the-counter drugs, supplements, and herbal products. Share this list with all healthcare providers involved in your care. Be proactive in asking about potential interactions and don’t hesitate to voice any concerns or report unusual symptoms.

Additional Considerations for Benadryl Use

Beyond interactions, there are several other factors to consider when using Benadryl to ensure its safe and effective use.

Important Factors to Consider

• Proper dosage and administration
• Potential side effects
• Use during pregnancy and breastfeeding
• Long-term use considerations
• Alternatives for specific conditions

What precautions should be taken when using Benadryl long-term? While Benadryl is generally safe for short-term use, long-term use, especially in older adults, may increase the risk of cognitive decline and other adverse effects. Always use the lowest effective dose for the shortest duration necessary, and consult with a healthcare provider about alternative treatments for chronic conditions.

In conclusion, understanding the interactions and proper use of Benadryl is crucial for maximizing its benefits while minimizing potential risks. Always consult with healthcare providers, stay informed about your medications, and report any unusual symptoms or concerns promptly. By doing so, you can ensure the safe and effective use of Benadryl as part of your overall health management strategy.

Benadryl Interactions Checker – Drugs.com

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There are 433 drugs known to interact with
Benadryl (diphenhydramine), along with
8 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
14 are major, 417 are moderate, and 2 are minor.

Does Benadryl interact with my other drugs?

Enter other medications to view a detailed report.

• View all 433 medications that may interact with Benadryl
• View Benadryl alcohol/food interactions (1)
• View Benadryl disease interactions (8)

Most frequently checked interactions

View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• acetaminophen
• albuterol
• amlodipine
• aspirin
• atorvastatin
• Claritin (loratadine)
• clonazepam
• cyclobenzaprine
• Flonase (fluticasone nasal)
• gabapentin
• hydroxyzine
• ibuprofen
• levothyroxine
• lisinopril
• magnesium oxide
• melatonin
• metformin
• omeprazole
• pantoprazole
• prednisone
• Singulair (montelukast)
• tramadol
• trazodone
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Benadryl alcohol/food interactions

There is 1 alcohol/food interaction with Benadryl (diphenhydramine).

Benadryl disease interactions

There are 8 disease interactions with Benadryl (diphenhydramine) which include:

• depression
• anticholinergic effects
• asthma/COPD
• cardiovascular
• renal/liver disease
• glaucoma
• liver disease
• resp depression

Report options

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More about Benadryl (diphenhydramine)

• Benadryl consumer information
• Compare alternatives
• Pricing & coupons
• Reviews (73)
• Drug images
• Latest FDA alerts (3)
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: anticholinergic antiemetics
• Breastfeeding
• En español

Related treatment guides

• Allergic Reactions
• Allergic Rhinitis
• Cough
• Cold Symptoms

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Benadryl and Alcohol/Food Interactions – Drugs.com

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Save

There is 1 alcohol/food/lifestyle interaction with Benadryl (diphenhydramine).

Ask your doctor before using diphenhydrAMINE together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking diphenhydrAMINE. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Benadryl drug interactions

There are 433 drug interactions with Benadryl (diphenhydramine).

Benadryl disease interactions

There are 8 disease interactions with Benadryl (diphenhydramine) which include:

• depression
• anticholinergic effects
• asthma/COPD
• cardiovascular
• renal/liver disease
• glaucoma
• liver disease
• resp depression

Report options

Loading. ..

QR code containing a link to this page

More about Benadryl (diphenhydramine)

• Benadryl consumer information
• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (73)
• Drug images
• Latest FDA alerts (3)
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: anticholinergic antiemetics
• Breastfeeding
• En español

Related treatment guides

• Allergic Reactions
• Allergic Rhinitis
• Cough
• Cold Symptoms

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Benadryl (diphenhydramine) side effects, warnings, uses

Benadryl

• Generic Name: Diphenhydramine
• Brand Name: Benadryl

• Overview
• Consumer Information
• Professional Information
• Related Resources 9000 6

Benadryl Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What is Benadryl?

Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of parkinsonism. Benadryl is available in generic form and over the counter (OTC).

What are the side effects of Benadryl?

Common side effects of Benadryl include:

• drowsiness,0006
• dizziness,
• incoordination,
• constipation,
• dry mouth/nose/throat,
• difficulty urinating or enlarged prostate,
• indigestion,
• blurred vision,
• double vision,
• tremor,
• loss of appetite,
• headache, or
• nausea.

Dosage for Benadryl

The typical dose of Benadryl is 25-50 mg every 4-6 hours.

What drugs, substances or supplements interact with Benadryl?

Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter cough, cold, allergy, or insomnia medicines, anxiety or sleep medicines, antidepressants, or any other medicines that make you sleepy, sleepy, or relaxed. Tell your doctor about all medications and supplements you are taking.

Benadryl during pregnancy and lactation

Benadryl has not been adequately evaluated in pregnant women. Benadryl is excreted in breast milk. Due to the risk of stimulation and seizures in infants, especially neonates and premature infants, breastfeeding mothers should not use antihistamines.

More Information

Our Benadryl Side Effects Center provides a comprehensive overview of the available drug information about the potential side effects of this medication.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

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Consumer Information Benadryl

Get emergency medical help if you have signs of an allergic reaction : urticaria; labored breathing; swelling of the face, lips, tongue, or throat.

Stop using diphenhydramine and call your doctor at once if you have:

• palpitations or fluttering in the chest;
• painful or difficult urination;
• little or no urination;
• confusion, feeling like you might pass out, or
• tightness in the neck or jaw, uncontrollable tongue movements.

Common side effects may include:

• dizziness, drowsiness, incoordination;
• dry mouth, nose or throat;
• constipation, indigestion;
• dry eyes, blurred vision; or
• daytime sleepiness or a feeling of “hangover” after nighttime use.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Benadryl (diphenhydramine)

Learn More ‘ Benadryl Professional Information

SIDE EFFECTS

Use of this product:

• marked drowsiness may occur
• avoid alcoholic beverages
• alcohol, sedatives and tranquilizers may increase drowsiness
• irritability may occur, especially in children
• be careful when driving or operating machinery

Read all FDA prescribing information for Benadryl (diphenhydramine)

Read More ‘ Benadryl Related Resources

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Read Benadryl User Reviews»

Patient Information x Benadryl is provided by Cerner Multum, Inc. and Benadryl consumer information is provided by First Databank, Inc., used under license and subject to their respective copyrights.

Benadryl (Diphenhydramine): Uses, Dosage, Side Effects, Interactions, Warning

Benadryl

• Generic Name: Diphenhydramine
• Brand Name: Benadryl

• Product Description
• Indications and Dosage
• warnings and precautions
• Overdose and contraindications
• Clinical pharmacology
• medicines

Product Description

What is Benadryl and how is it used?

Benadryl is a prescription medicine used to treat the symptoms of allergic reactions, insomnia, and motion sickness. Benadryl can be used alone or with other medicines.

Benadryl belongs to a class of drugs called 1st generation antihistamines, antiemetics.

Benadryl is not known to be safe and effective in children under 2 years of age.

What are the possible side effects of Benadryl?

Benadryl can cause serious side effects, including:

• rapid heartbeat or fluttering in the chest,
• painful or difficult urination,
• little or no urination,
• confusion ,
• lightheadedness ,
• tightness in the neck or jaw, and
• uncontrollable movements of your tongue

Get medical help right away if you have any of the above symptoms.

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The most common side effects of Benadryl include:

• dizziness,
• drowsiness,
• loss of coordination,
• dry mouth, nose or throat,
• constipation, 900 06
• upset stomach,
• dry eyes,
• blurred vision and
• daytime sleepiness or hangover

Tell your doctor if you have any side effects that bother you or that don’t go away.

These are not all possible side effects of Benadryl. For more information, contact your doctor or pharmacist.

Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

DESCRIPTION

Benadryl Allergy contains the histamine blocker diphenhydramine. This product relieves: runny nose; sneezing itchy, watery eyes; itching in the throat.

omega-3 acid ethyl ester caps

Ingredient

Inactive Ingredients

candelilla wax, colloidal silicon dioxide, crospovidone, hypromellose, microcrystalline cellulose, polyethylene glycol, providone, pregelatinized starch, starch, stearic acid, titanium dioxide and talc

* Effect on general nasal symptoms in allergy to Benadryl (diphenhydramine) 50 mg 3 times a day. Use as directed.

Indications and dosage

INDICATIONS

Benadryl Allergy (diphenhydramine)

• temporarily relieves these symptoms caused by hay fever or other upper respiratory allergies:
  • runny nose

  90 011 sneezing

  • itchy, watery eyes
  • itchy nose or throat
• temporarily relieves these symptoms due to a cold:
  • runny nose
  • sneezing

DOSAGE AND ADMINISTRATION

Directions

• do not use more than indicated (see OVERDOSE warning)

** 12. 5 mg dosage not available in Benadryl (diphenhydramine) Allergy Kapseals.

Other information

• Store between 59° and 77° F in a dry place.
• protect from light

HOW SUPPLIED

Available in:
Ultratabs: Box of 24, 48 and 100 tablets
Capsals capsules: box of 24 and 48

FDA revision date: 07/01/1997

Side effects and drug interactions

SIDE EFFECTS

When using this product:

• marked drowsiness may occur
• avoid alcoholic beverages
• alcohol, sedatives and tranquilizers may increase drowsiness
• may cause excitability, especially in children
• be careful when driving or operating machinery

DRUG INTERACTIONS

Consult your doctor or pharmacist before use if you are taking sedatives or tranquilizers.

Warnings and Precautions

WARNINGS

Alcohol Warning : If you drink 3 or more alcoholic drinks every day, ask your doctor if you should take paracetamol or other pain/fever medications. Acetaminophen can cause liver damage.

PRECAUTIONS

No information provided.

Overdose and contraindications

OVERDOSAGE

Overdose warning : Taking more than the recommended dose may cause liver damage. In case of overdose, seek medical attention or contact a Poison Control Center immediately. Prompt medical attention is important for both adults and children, even if you don’t notice any signs or symptoms.

CONTRAINDICATIONS

No information provided.

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Clinical pharmacology

CLINICAL PHARMACOLOGY

No information provided.

Medication Guide

PATIENT INFORMATION

Do not use

• with another product containing any of these active ingredients
• if you are currently taking a prescription monoamine oxidase (MA) inhibitor OI) (certain drugs used to treat depression, mental or emotional states or Parkinson’s disease), or within 2 weeks after stopping the MAOI drug. If you are unsure if your prescription drug contains an MAOI, check with your doctor or pharmacist before taking this product.
• with any other product containing diphenhydramine, even if used on the skin.

Consult a physician before use if you have heart disease

Consult your doctor or pharmacist before use if you are taking sedatives or tranquilizers.

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When using this product

do not use more than indicated

• marked drowsiness may occur
• avoid alcoholic beverages
• alcohol, sedatives and tranquilizers may increase drowsiness children

Stop using and see a doctor if

• redness or swelling
• severe sore throat
• You are nervous, experience dizziness or insomnia

,

• new symptoms of
• fever are increased or more than 3 days

,

• pain, cough or nose, accumulation worsens or lasts more than 5 days (children) or 7 days (adults) 9000,
• pain in the pain in sore throat lasts more than 2 days, accompanied by fever, headache, rash, swelling, nausea or vomiting or followed by
• cough comes back or occurs with persistent rash or headache.