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Is dicyclomine a narcotic. Dicyclomine Hydrochloride: Uses, Benefits, and Side Effects in IBS Treatment

by alexxlab

Is dicyclomine a narcotic. How does dicyclomine hydrochloride work for irritable bowel syndrome. What are the potential side effects of dicyclomine. When should you take dicyclomine for optimal results. Can dicyclomine cause drowsiness or affect driving ability.

Understanding Dicyclomine Hydrochloride: An Anticholinergic for IBS

Dicyclomine hydrochloride is a medication primarily used in the treatment of irritable bowel syndrome (IBS). It belongs to a class of drugs known as anticholinergics or antispasmodics. These medications work by blocking the action of acetylcholine, a neurotransmitter responsible for involuntary muscle movements in the digestive tract.

Is dicyclomine a narcotic? No, dicyclomine hydrochloride is not a narcotic or a controlled substance. It is a prescription medication specifically designed to alleviate symptoms associated with IBS, such as abdominal pain and cramping.

How Dicyclomine Works in the Body

Dicyclomine hydrochloride functions by:

  • Inhibiting involuntary muscle contractions in the gastrointestinal tract
  • Slowing down the natural movements of the gut
  • Relaxing muscles in the stomach and intestines

By reducing these muscle spasms and movements, dicyclomine helps alleviate the colicky-type pain often experienced by individuals with IBS.

Proper Usage and Dosage of Dicyclomine Hydrochloride

For optimal results, it’s crucial to take dicyclomine hydrochloride as prescribed by your healthcare provider. Typically, the medication is taken orally four times a day.

When to Take Dicyclomine

For best absorption and effectiveness, take dicyclomine:

  • On an empty stomach
  • 30 minutes to 1 hour before meals

Does the timing of dicyclomine intake matter? Yes, taking dicyclomine on an empty stomach and before meals can enhance its effectiveness in managing IBS symptoms.

Dosage Considerations

Your doctor may start you on a lower dose and gradually increase it to minimize side effects. Always follow your healthcare provider’s instructions carefully and never adjust the dosage without consultation.

Can you take dicyclomine with antacids? It’s best to avoid taking dicyclomine at the same time as antacids, as they can lower the absorption of the medication. If you need to take both, space them out by at least an hour.

Potential Side Effects and Precautions of Dicyclomine Use

While dicyclomine can be effective in managing IBS symptoms, it’s important to be aware of potential side effects and take necessary precautions.

Common Side Effects

Some individuals may experience:

  • Drowsiness
  • Light-headedness
  • Dry mouth
  • Blurred vision
  • Constipation

Does dicyclomine cause drowsiness? Yes, drowsiness is a common side effect of dicyclomine. It’s important to be cautious when driving or operating machinery until you know how the medication affects you.

Serious Side Effects

While less common, some individuals may experience more severe side effects, including:

  • Abdominal bloating
  • Mental confusion
  • Mood changes
  • Rapid heartbeat
  • Hallucinations

If you experience any of these serious side effects, it’s crucial to consult your healthcare provider immediately.

Interactions and Contraindications of Dicyclomine

Dicyclomine can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects.

Medications to Avoid

Dicyclomine may interact with:

  • Gastrointestinal motility drugs
  • Opioids
  • Antipsychotics
  • Antihistamines
  • Muscle relaxants
  • Certain seizure medications

Should you avoid alcohol while taking dicyclomine? Yes, it’s advisable to avoid alcohol consumption while on dicyclomine, as it can enhance the drowsiness caused by the medication.

Contraindications

Dicyclomine is not suitable for everyone. It should not be used by:

  • Children younger than 6 months old due to the risk of serious side effects
  • Individuals with certain medical conditions, such as glaucoma or myasthenia gravis
  • Pregnant or breastfeeding women without consulting a healthcare provider

Effectiveness of Dicyclomine in Managing IBS Symptoms

Research has shown that dicyclomine can be effective in managing various symptoms associated with IBS.

Pain Relief

Is dicyclomine a painkiller? While not classified as a traditional painkiller, dicyclomine effectively alleviates colicky-type pain associated with IBS by reducing muscle spasms in the gastrointestinal tract.

Impact on Bowel Movements

Does dicyclomine help with bowel movements? Some studies have found that dicyclomine can promote better bowel movements in addition to relieving abdominal pain. However, its primary function is to reduce muscle spasms rather than directly affect bowel habits.

Can dicyclomine cause constipation? In some cases, dicyclomine may lead to constipation as a side effect. If you experience persistent constipation while taking this medication, consult your healthcare provider for guidance.

Dicyclomine and Weight: Separating Fact from Fiction

There are often misconceptions about the effects of medications on body weight. Let’s address a common question regarding dicyclomine and weight.

Impact on Body Weight

Does dicyclomine cause weight loss? No, dicyclomine is not designed to cause weight loss and is not used as a weight loss medication. Its primary function is to manage IBS symptoms by reducing muscle spasms in the digestive tract.

If you experience unexpected weight changes while taking dicyclomine, it’s important to consult your healthcare provider. Weight fluctuations could be related to changes in your IBS symptoms or other factors unrelated to the medication.

Dietary Considerations

While taking dicyclomine, it’s essential to maintain a balanced diet that supports your digestive health. Your healthcare provider may recommend specific dietary modifications to complement your IBS treatment plan.

Long-term Use and Safety of Dicyclomine Hydrochloride

For individuals with chronic IBS symptoms, long-term use of dicyclomine may be necessary. However, it’s important to understand the implications of extended use and follow appropriate safety measures.

Monitoring Long-term Use

When using dicyclomine for an extended period:

  • Regular check-ups with your healthcare provider are essential
  • Report any changes in symptoms or new side effects promptly
  • Periodic reassessment of the medication’s effectiveness may be necessary

Is it safe to use dicyclomine indefinitely? While dicyclomine can be used long-term for managing IBS symptoms, ongoing monitoring by a healthcare professional is crucial to ensure its continued safety and effectiveness.

Potential for Tolerance

Some individuals may develop tolerance to dicyclomine over time, requiring dosage adjustments. Never increase your dose without consulting your healthcare provider.

Alternatives and Complementary Approaches to IBS Management

While dicyclomine can be effective for many individuals with IBS, it’s not the only treatment option available. Exploring alternative and complementary approaches can provide a more comprehensive management strategy.

Other Medications

Alternative medications for IBS management may include:

  • Antidiarrheal agents
  • Antidepressants (for pain management)
  • Probiotics
  • Fiber supplements

Lifestyle Modifications

Complementary approaches to managing IBS symptoms include:

  • Dietary changes (e.g., low FODMAP diet)
  • Stress reduction techniques (e.g., meditation, yoga)
  • Regular exercise
  • Adequate sleep

Can lifestyle changes replace medication for IBS management? For some individuals, lifestyle modifications may be sufficient to manage mild IBS symptoms. However, many people benefit from a combination of medication and lifestyle changes for optimal symptom control.

It’s important to work closely with your healthcare provider to develop a comprehensive treatment plan that addresses your specific needs and symptoms. Remember that what works for one person may not be as effective for another, and finding the right approach often requires patience and some trial and error.

In conclusion, dicyclomine hydrochloride plays a significant role in managing irritable bowel syndrome symptoms for many individuals. By understanding its mechanism of action, proper usage, potential side effects, and limitations, patients can make informed decisions about their treatment in consultation with their healthcare providers. While dicyclomine can be an effective tool in the IBS management toolkit, it’s essential to consider it as part of a broader approach that may include lifestyle modifications and other therapeutic strategies.

Why Dicyclomine Hydrochloride is used in the treatment of irritable bowel syndrome.

1. Is dicyclomine hydrochloride a narcotic?

Dicyclomine hydrochloride is used in the treatment of irritable bowel syndrome. It belongs to the class of drugs known as anticholinergics/antispasmodics. Anticholinergics work by blocking the action of acetylcholine, a type of neurotransmitter, thereby inhibiting involuntary muscle movements. This drug is not a controlled substance or narcotic.

2. Are dicyclomine and dicyclomine hydrochloride both the same?

Yes. Both are the same. Dicyclomine hydrochloride is used to treat irritable bowel syndrome and belongs to the class of drugs known as anticholinergics/antispasmodics.

3. Does dicyclomine hydrochloride make you sleepy?

Yes, be warned that Dicyclomine Hydrochloride may cause drowsiness as well as light-headedness, which is why driving a car or operating machinery is not recommended until you know how this medication affects you. Alcohol too can add to the drowsiness caused by Dicyclomine Hydrochloride.

4. Is Dicyclomine Hydrochloride a painkiller?

Dicyclomine Hydrochloride is a prescription drug used to alleviate colicky-type pain due to muscle spasms associated with irritable bowel syndrome. Dicyclomine HCL slows the movement of the gastrointestinal tract. However, there are side effects such as drowsiness and abdominal bloating.

5. When should you take Dicyclomine Hydrochloride?

Dicyclomine hydrochloride is used in the treatment of irritable bowel syndrome. It is best to take this medication on an empty stomach and 30 minutes to 1 hour before a meal. One needs to take this medication as prescribed. And do consult a doctor if you face any side effects such as abdominal bloating, hallucinations, rapid heartbeat, or mental confusion.

6. Will Dicyclomine Hydrochloride help me poop?

In one study, researchers found that Dicyclomine HCL helped relieve abdominal pain and promoted better bowel movements. However, the drug is mostly used to alleviate colicky-type pain due to muscle spasms associated with irritable bowel syndrome.

7. Will Dicyclomine Hydrochloride make you sleepy?

One of the known side effects of Dicyclomine Hydrochloride is drowsiness and light-headedness. This is why it is not recommended for someone on the drug to drive cars or operate heavy machinery until they know what effect the drug has on them.

8. Can you take Dicyclomine Hydrochloride on an empty stomach?

Dicyclomine HCL should be taken on an empty stomach and 30 minutes to 1 hour before a meal. Do consult a doctor if you face any side effects such as abdominal bloating, mental confusion, or mood changes.

9. Can Dicyclomine Hydrochloride make you lose weight?

Dicyclomine Hydrochloride does not make you lose weight. Dicyclomine Hydrochloride is a prescription drug, which belongs to a class of medication known as anticholinergics or antispasmodics. It is used in the treatment of irritable bowel syndrome or IBS.

10. What medication should not be taken with dicyclomine?

Dicyclomine Hydrochloride can have serious interactions with medication gastrointestinal motility, opioids, growth hormone, antipsychotics, antihistamines and medications that cause sedation, muscle relaxants, some seizure medications. Consult your healthcare professional for more information.

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Dicyclomine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Dicyclomine is used to treat a certain type of intestinal problem called irritable bowel syndrome. It helps to reduce the symptoms of stomach and intestinal cramping. This medication works by slowing the natural movements of the gut and by relaxing the muscles in the stomach and intestines. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.This medication must not be used by children younger than 6 months old because of the risk of serious side effects.

How to use Dicyclomine HCL

Take this medication by mouth with or without food as directed by your doctor, usually 4 times a day. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Mix the dose of liquid with an equal amount of water before taking it.

Antacids lower the absorption of dicyclomine. Do not take this medication at the same time as antacids. If you are taking an antacid, take it after meals and take dicyclomine before meals.

The dosage is based on your age, medical condition, and response to treatment.

Do not increase your dose or take this drug more often without your doctor’s approval. Your condition will not improve any faster and the risk of serious side effects may increase.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Dizziness, drowsiness, lightheadedness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. To relieve dry eyes, consult your pharmacist for artificial tears or other eye lubricants.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: decreased sweating, dry/hot/flushed skin, fast/irregular heartbeat, loss of coordination, trouble speaking, mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement), difficulty urinating, decreased sexual ability.

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking dicyclomine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, little/no stomach acid, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), myasthenia gravis, liver problems, kidney problems.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, fast heartbeat, and urination problems. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. The manufacturer recommends that you do not breast-feed while using this drug. Consult your doctor for more details.

Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: potassium tablets/capsules, drugs that are affected by slowed gut movement (such as pramlintide).

Dicyclomine may affect the absorption of other products such as levodopa, certain azole anti-fungal drugs (ketoconazole, itraconazole), slowly-dissolving forms of digoxin, among others. If you are taking either ketoconazole or itraconazole, take it at least 2 hours before dicyclomine.

Many other drugs that also cause dry mouth and constipation may interact with anticholinergics/antispasmodics such as dicyclomine. Tell your doctor or pharmacist about all the products you take, including: other anticholinergic drugs (such as atropine, glycopyrrolate, scopolamine), other antispasmodic drugs (such as clidinium, propantheline), belladonna alkaloids, certain drugs used to treat Parkinson’s disease (such as trihexyphenidyl), certain drugs used to treat irregular heart rhythms (such as disopyramide, quinidine), MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenothiazines (such as chlorpromazine), tricyclic antidepressants (such as amitriptyline).

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or a fast heartbeat. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including gastric secretion tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Dicyclomine HCL interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: large pupils, hot/dry skin, fever, severe dizziness, severe thirst, difficulty swallowing, mental/mood changes (such as confusion, unusual excitement), fast/irregular heartbeat, muscle weakness, inability to move (paralysis), slowed breathing, fainting, seizures.

Do not share this medication with others.

Management of digestive disorders may include lifestyle changes such as stress reduction programs, exercise, stopping smoking, and dietary changes, in addition to medication. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Keep all medical appointments so that your doctor can periodically monitor your progress and check for side effects. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

dicyclomine 20 mg tablet

Color: blueShape: roundImprint: M D6

This medicine is a blue, round, tablet imprinted with “M D6”.

dicyclomine 20 mg tablet

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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Color: blueShape: oblongImprint: LAN 0586

This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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Color: blueShape: oblongImprint: West- ward 3126

This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

What is Trigan D? Its effect on the body

A common medicine – Trigan D, when the dosage increases, it begins to act like a drug. Tablets have a versatile effect on the body. They simultaneously anesthetize and have anti-vasospasm properties. Trigan D is sold both in the form of tablets and in the form of a solution.

Today there are no difficulties in purchasing drugs. Drugs that cannot be bought in pharmacies are easily obtained in other ways – via the Internet, distributors in universities, on the streets. It is enough to transfer money to a bank card and find a “bookmark” in the place indicated by the supplier. But illicit substances are not always used as drugs. Often, addiction arises from taking completely legal medications. They are available in pharmacies and available by prescription. And sometimes – and without it.

The result of taking Trigan D in the dose recommended by the doctor is a quick and effective elimination of pain. Exceeding the dosage entails completely different consequences.

Trigan D: effects on the body

Contains paracetamol and dicycloverine. The drug causes a feeling of euphoria, has hallucinogenic properties. The strongest antispasmodic causes blockage of receptors, which leads to the appearance of a trip.

Few of the young generation who use Trigan D most often know that large doses of paracetamol destroy the liver. In Trigan, there is a huge amount of this substance and taking the drug in high dosages will certainly cause the effects of toxins on the internal organs. 5-6 tablets taken at a time will cause serious damage to the liver.

What is Trigan D

Why produce such hazardous drugs? Trigan is a medical remedy used to relieve spasms, pain relief, and sedation. Tablets have a prolonged powerful action, therefore they are used to relieve acute and severe pain – renal and hepatic colic, with irritable bowel syndrome, dysmenorrhea, pylorospasm. A doctor can also prescribe Trigan for a severe cold as an antipyretic, if other drugs do not have the desired effect.

If at small doses the drug causes pleasant relaxation and calmness, then when they are exceeded, on the contrary, irrepressible energy, hallucinations, trips, which are not inferior in intensity to those caused by the use of synthetic drugs.

Features of the effect of Trigan on the body

The onset of the effect of Trigan D on the body becomes noticeable 30 minutes after taking the drug. After 2 hours, the effect reaches its peak and becomes as strong as possible. What happens to the person who has taken the substance? He begins to see hallucinations, unrealistic pictures, can communicate with “imaginary friends.” In some cases, addicts see happy and funny pictures, in others they get into a terrifying and frightening virtual environment.

In many ways, the effect of taking Trigan tablets depends on the individual characteristics of the organism. For this reason, sometimes even a small dose of the drug can cause nightmarish hallucinations, panic, provoking dangerous actions on the part of the patient.

The hallucinogenic effect of Trigan D is the result of exposure to dicycloverine. Often, in order to obtain the most powerful result from taking the drug, the substance is isolated from the composition of the funds and sold in the form of an extract.

Why is addiction to Trigan D dangerous? Unfortunately, teenagers, who most often fall victim to the drug, do not think about what is happening to their body, more and more plunging into addiction. And a terrible thing happens – liver failure, the development of mental illness, the risk of developing a coma increases at times.

How to help a sick person

How to understand that a loved one needs help? Symptoms of an overdose of Trigan D are immediately noticeable:

  • very severe chills up to fever;
  • convulsions, paralysis;
  • severe drowsiness;
  • nausea, vomiting;
  • pain in the gastrointestinal tract;
  • auditory and visual hallucinations.

Failure to provide assistance to the patient leads to the development of necrosis of the liver and kidneys, resulting in death. Simple analgesics can cause a quick and painful death.

What to do? First of all, accept a simple fact – you cannot cope with the dependence on Trigan D on your own. The help of specialists is needed, and it should be versatile. Intervention requires both the physical condition of the patient and psychological dependence.

Trigan D is as addictive as cocaine, heroin, amphetamines. Heart-to-heart conversations will not help solve the problem – the treatment will take a long time and considerable strength.

Drug addiction treatment at the Novaya Zhizn medical center will help solve the problem of drug addiction from Trigan D in the most effective way. The specialists of the clinic will carry out all the necessary procedures for the rapid cleansing of the body from traces of the drug, work out the psychological aspects of addiction, and help you learn how to live without hallucinogenic substances. Complex treatment gives the most effective result.

Dicyclomine | tor4 – here about the culture of consumption and the whole truth about drugs!

Dicyclomine is an anticholinergic (tertiary amine) that blocks muscarinic receptors. Dicyclomine is known as dicycloverine hydrochloride. Dicycloverine contains 72 percent of the anti-muscarinic potency of atropine. It was invented in the USA in 1947.

Chemical compound:
IUPAC 2-(diethylamino)ethyl bi(cyclohexane)-1-carboxylate
Gross
formula: C19h45NO2
Mol.
mass: 309.487 g/mol
CAS 77-19-0
PubChem: 3042
DrugBank: APRD00113
Classification: ATC A03AA07
Pharmacokinetics: Plasma protein binding >99%
Half-life: 5 hours

Pharmacodynamics and clinical use

Pharmacological action: anticholinergic, myotropic , antispasmodic. Eliminates spasm of smooth muscles and reduces the pain syndrome caused by it.
Animal studies (in vitro studies using isolated guinea pig small intestine) show that the effect is mediated by two mechanisms: firstly, a specific anticholinergic effect on acetylcholine receptor sites, similar to that of atropine (antimuscarinic activity), secondly direct effect on smooth muscles, as evidenced by the ability of dicycloverine to block bradykinin- and histamine-induced spasms (atropine does not change the response to these two agonists). In in vivo studies in cats and dogs, dicycloverine was approximately equally effective against acetylcholine and barium chloride induced intestinal spasms. The absence of a significant effect of dicycloverine on the pupil was shown (in tests for evaluating mydriatic effects in mice, the activity was approximately 1/500 of the activity of atropine), as well as on the secretion of the salivary glands (in studies in rabbits, it showed 1/300 of the activity of atropine).

Interaction with other medicinal products (PM): Effects of dicycloverine, incl. side effects, may enhance drugs with anticholinergic activity: amantadine, class I antiarrhythmics (eg quinidine), antihistamine drugs, antipsychotic drugs (eg phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetics, tricyclic antidepressants. Anticholinergic drugs counteract the effect of antiglaucoma drugs. In the presence of elevated intraocular pressure, anticholinergic drugs can be dangerous when used simultaneously with corticosteroids; may affect the absorption of digoxin in the gastrointestinal tract and, as a result, increase the concentration of digoxin in the blood serum; may counteract the effects of substances that alter gastrointestinal motility (metoclopramide). Antacids can affect the absorption of anticholinergic drugs, so their combined use should be avoided. Inhibition of hydrochloric acid secretion by anticholinergic drugs counteracts the action of substances used to treat achlorhydria or test gastric secretion.
In particular, dicyclomine is used to treat intestinal motility, a symptom of irritable bowel syndrome (also known as colon spasms). It relieves muscle spasms and spasms in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells (smooth muscle relaxant). Its effectiveness as a drug against urinary incontinence is being investigated.

Dosage:
Single and daily doses depend on the type of pathology and individual characteristics. The drug is recommended to be taken only after consultation with your doctor. Usually, the drug is prescribed in the following dosages:
Oral: Initial dose 80 mg/day (4 equal doses), adjusted to 160 mg/day.
Intramuscular: 20 mg 4 times a day.
IV: Not used.

Contraindications and side effects

Contraindications: hypersensitivity; intestines; use may contribute to the appearance or exacerbation of such a serious complication as toxic megacolon), peptic ulcer of the stomach and duodenum, reflux esophagitis, unstable conditions of the cardiovascular system, acute bleeding, glaucoma, myasthenia gravis, children’s age (up to 6 months).

Restrictions for use: autonomic neuropathy, impaired liver and kidney function (decreased excretion by the kidneys may increase the risk of side effects), tachycardia, incl. with hyperthyroidism (possibly increased), hypertension (possible exacerbation), heart disease (including coronary artery disease, congestive heart failure, tachyarrhythmia), hiatal hernia, prostatic hypertrophy.

Use during pregnancy and lactation: during pregnancy, use only if necessary. There are no adequate and well-controlled studies in humans. Contraindicated in breastfeeding (diccycloverine hydrochloride has been reported to be excreted in breast milk; respiratory distress syndrome may develop in breastfed children).

Side effects: can cause a wide range of anticholinergic side effects, which are conventionally divided into two types: mental (confusion, delirium, short-term memory impairment, disorientation, decreased attention (including driving vehicles)) and physical (dry mouth, constipation, drop in blood pressure, urinary retention (especially in men with prostatic hyperplasia), decreased visual acuity, reduced sweating against the background of elevated body temperature, sexual disorders, deterioration in the condition of patients suffering from glaucoma (due to increased intraocular pressure ), nausea
Data on the potential carcinogenicity and mutagenicity of dicycloverine hydrochloride in humans are not available. Long-term animal studies evaluating the potential carcinogenicity of dicycloverine hydrochloride have not been conducted. In studies in rats, when administered at doses up to 100 mg / kg / day, dicycloverine hydrochloride did not have a dangerous effect on reproduction, conception and childbirth.

Overdose: Symptoms: headache, nausea, vomiting, prolonged blurred vision, dilated pupils, fever, dry skin, dizziness, dry mouth, difficulty swallowing, CNS stimulation. Perhaps curariform action i.e. neuromuscular blockade leading to muscle weakness and paralysis. In some cases, premature death (death) has been observed after taking a single dose of 200 mg or more. If you have symptoms of an overdose and / or mistakenly taking the drug, you should immediately consult a doctor. In Egypt, Brazil, Ukraine, dicyclomine is popular as a drug.

Brand names

In America it is sold under the brand names Bentyl, Byclomine, Dibent, Di-Spaz, Dilomine.
In the UK it is sold under the brand names Merbentyl (containing 10 mg dicycloverine) and Merbentyl 20 (containing 20 mg dicycloverine).