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Is dicyclomine a narcotic. Dicyclomine Hydrochloride: A Comprehensive Guide to IBS Treatment

by alexxlab

Is dicyclomine a narcotic. How does dicyclomine hydrochloride treat irritable bowel syndrome. What are the side effects of dicyclomine. When should you take dicyclomine hydrochloride. Can dicyclomine hydrochloride help with bowel movements.

Understanding Dicyclomine Hydrochloride: An Anticholinergic for IBS

Dicyclomine hydrochloride is a medication primarily used in the treatment of irritable bowel syndrome (IBS). It belongs to a class of drugs known as anticholinergics or antispasmodics. These medications work by blocking the action of acetylcholine, a neurotransmitter responsible for involuntary muscle movements in the digestive tract.

Contrary to common misconceptions, dicyclomine is not a narcotic or a controlled substance. It is a prescription medication designed to alleviate symptoms associated with IBS, particularly abdominal pain and discomfort caused by muscle spasms in the gastrointestinal system.

How Does Dicyclomine Work?

Dicyclomine hydrochloride functions by slowing down the natural movements of the gut and relaxing the muscles in the stomach and intestines. This mechanism of action helps reduce the frequency and severity of muscle spasms, which are often the source of pain and discomfort in IBS patients.

  • Blocks acetylcholine action
  • Reduces involuntary muscle movements
  • Slows gastrointestinal motility
  • Relaxes stomach and intestinal muscles

Proper Usage and Dosage of Dicyclomine Hydrochloride

For optimal results, it’s crucial to take dicyclomine hydrochloride as prescribed by your healthcare provider. Typically, the medication is taken orally four times a day. To minimize the risk of side effects, doctors often start patients on a low dose and gradually increase it as needed.

Is there a specific time to take dicyclomine hydrochloride? It is generally recommended to take this medication on an empty stomach, approximately 30 minutes to 1 hour before meals. This timing allows for better absorption and efficacy of the drug.

Dosage Forms and Administration

  1. Tablets: Usually available in 10mg and 20mg strengths
  2. Liquid: Requires careful measurement using a special device or spoon
  3. Capsules: Often prescribed for extended-release formulations

When using the liquid form, it’s important to mix the dose with an equal amount of water before ingestion. Avoid using household spoons for measurement, as they may not provide accurate dosing.

Potential Side Effects and Precautions

While dicyclomine hydrochloride is effective in managing IBS symptoms, it’s not without potential side effects. Common adverse reactions include drowsiness, dry mouth, blurred vision, and constipation. More severe side effects, though rare, can occur and require immediate medical attention.

Can dicyclomine hydrochloride cause drowsiness? Yes, one of the notable side effects of this medication is drowsiness or light-headedness. Due to this, it’s advised not to drive or operate heavy machinery until you understand how the drug affects you personally.

Important Precautions

  • Avoid alcohol consumption while taking dicyclomine
  • Inform your doctor of all other medications you’re taking
  • Do not use in children younger than 6 months old
  • Use caution if you have a history of glaucoma or urinary retention

It’s crucial to consult your healthcare provider if you experience any unusual or severe side effects such as mental confusion, rapid heartbeat, or hallucinations.

Interactions with Other Medications

Dicyclomine hydrochloride can interact with various other medications, potentially altering their effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all medications, supplements, and herbal products you’re currently taking.

Which medications should not be taken with dicyclomine? Dicyclomine may interact seriously with several types of drugs, including:

  • Opioids
  • Antipsychotics
  • Antihistamines
  • Muscle relaxants
  • Certain seizure medications
  • Medications affecting gastrointestinal motility

It’s particularly important to note that antacids can lower the absorption of dicyclomine. If you need to take both, ensure they are not taken simultaneously. Consult your healthcare provider for guidance on proper timing and potential alternatives.

Efficacy in Treating Irritable Bowel Syndrome

Dicyclomine hydrochloride has shown significant efficacy in alleviating symptoms associated with IBS, particularly in managing abdominal pain and discomfort. Its antispasmodic properties help reduce the frequency and intensity of muscle spasms in the digestive tract, providing relief to many patients.

Does dicyclomine hydrochloride help with bowel movements? While the primary function of dicyclomine is to reduce muscle spasms and associated pain, some studies have indicated that it may also help promote better bowel movements in certain patients. However, its main therapeutic effect is centered on pain relief rather than directly affecting bowel habits.

Clinical Evidence

Research has demonstrated the effectiveness of dicyclomine in IBS treatment:

  • Reduction in abdominal pain intensity
  • Decrease in frequency of painful episodes
  • Improvement in overall quality of life for IBS patients
  • Potential positive effects on bowel movement regularity in some cases

It’s important to note that individual responses to dicyclomine can vary, and what works well for one patient may not be as effective for another. Regular follow-ups with your healthcare provider are crucial to assess the medication’s efficacy and make any necessary adjustments to your treatment plan.

Dicyclomine vs. Other IBS Treatments

While dicyclomine hydrochloride is a widely prescribed medication for IBS, it’s not the only treatment option available. Understanding how it compares to other treatments can help patients and healthcare providers make informed decisions about managing IBS symptoms.

Comparison with Other Antispasmodics

  • Hyoscyamine: Similar mechanism of action, but may have different side effect profiles
  • Mebeverine: Less systemic side effects, but may not be as potent for severe spasms
  • Peppermint oil: Natural alternative with antispasmodic properties, but may cause heartburn

Other IBS Treatment Approaches

  1. Dietary modifications: Eliminating trigger foods, increasing fiber intake
  2. Stress management techniques: Cognitive behavioral therapy, mindfulness
  3. Probiotics: May help balance gut microbiota
  4. Antidepressants: Low-dose tricyclic antidepressants or SSRIs for pain modulation
  5. Loperamide: For IBS with predominant diarrhea

The choice of treatment often depends on the specific symptoms, severity of the condition, and individual patient factors. A comprehensive approach combining medication with lifestyle modifications often yields the best results in managing IBS.

Long-term Use and Safety Considerations

While dicyclomine hydrochloride can be an effective treatment for IBS symptoms, long-term use requires careful consideration and monitoring. Patients and healthcare providers should weigh the benefits against potential risks associated with prolonged use of anticholinergic medications.

Is it safe to use dicyclomine hydrochloride long-term? Long-term use of dicyclomine is generally considered safe when used as directed and under medical supervision. However, regular follow-ups and periodic reassessment of the treatment plan are essential to ensure continued efficacy and safety.

Potential Long-term Effects

  • Cognitive impacts: Some studies suggest a potential link between long-term anticholinergic use and cognitive decline in older adults
  • Tolerance: Some patients may develop tolerance over time, requiring dose adjustments
  • Dependence: While not a narcotic, sudden discontinuation may lead to withdrawal symptoms in some cases
  • Gastrointestinal changes: Prolonged use may affect gut motility patterns

It’s crucial for patients to communicate openly with their healthcare providers about any changes in symptoms, side effects, or concerns regarding long-term use. Regular monitoring and periodic attempts to reduce dosage or frequency of use may be recommended to minimize potential risks while maintaining symptom control.

Special Populations and Considerations

Certain groups of patients require special consideration when it comes to using dicyclomine hydrochloride. These populations may be at higher risk for side effects or may require dosage adjustments to ensure safe and effective treatment.

Elderly Patients

Older adults may be more sensitive to the effects of anticholinergic medications like dicyclomine. They may experience more pronounced side effects, particularly cognitive impacts and increased risk of falls due to dizziness or blurred vision. Dosage adjustments and closer monitoring are often necessary for this population.

Pregnant and Breastfeeding Women

The safety of dicyclomine during pregnancy and breastfeeding is not well-established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider to weigh the potential risks and benefits of treatment.

Patients with Comorbidities

  • Glaucoma: Dicyclomine may increase intraocular pressure
  • Prostatic hypertrophy: Risk of urinary retention may be increased
  • Cardiovascular conditions: Caution is advised due to potential effects on heart rate
  • Liver or kidney impairment: May affect drug metabolism and elimination

Individualized treatment plans and close monitoring are crucial for these special populations to ensure safe and effective management of IBS symptoms while minimizing risks associated with dicyclomine use.

In conclusion, dicyclomine hydrochloride remains an important tool in the management of irritable bowel syndrome. Its efficacy in reducing abdominal pain and discomfort associated with IBS has been well-documented. However, like all medications, it comes with potential side effects and considerations for long-term use. Proper usage, regular follow-ups with healthcare providers, and awareness of individual risk factors are key to maximizing the benefits of dicyclomine while minimizing potential risks. As research in IBS treatment continues to evolve, dicyclomine hydrochloride maintains its place as a valuable option in the therapeutic arsenal against this challenging gastrointestinal disorder.

Why Dicyclomine Hydrochloride is used in the treatment of irritable bowel syndrome.

1. Is dicyclomine hydrochloride a narcotic?

Dicyclomine hydrochloride is used in the treatment of irritable bowel syndrome. It belongs to the class of drugs known as anticholinergics/antispasmodics. Anticholinergics work by blocking the action of acetylcholine, a type of neurotransmitter, thereby inhibiting involuntary muscle movements. This drug is not a controlled substance or narcotic.

2. Are dicyclomine and dicyclomine hydrochloride both the same?

Yes. Both are the same. Dicyclomine hydrochloride is used to treat irritable bowel syndrome and belongs to the class of drugs known as anticholinergics/antispasmodics.

3. Does dicyclomine hydrochloride make you sleepy?

Yes, be warned that Dicyclomine Hydrochloride may cause drowsiness as well as light-headedness, which is why driving a car or operating machinery is not recommended until you know how this medication affects you. Alcohol too can add to the drowsiness caused by Dicyclomine Hydrochloride.

4. Is Dicyclomine Hydrochloride a painkiller?

Dicyclomine Hydrochloride is a prescription drug used to alleviate colicky-type pain due to muscle spasms associated with irritable bowel syndrome. Dicyclomine HCL slows the movement of the gastrointestinal tract. However, there are side effects such as drowsiness and abdominal bloating.

5. When should you take Dicyclomine Hydrochloride?

Dicyclomine hydrochloride is used in the treatment of irritable bowel syndrome. It is best to take this medication on an empty stomach and 30 minutes to 1 hour before a meal. One needs to take this medication as prescribed. And do consult a doctor if you face any side effects such as abdominal bloating, hallucinations, rapid heartbeat, or mental confusion.

6. Will Dicyclomine Hydrochloride help me poop?

In one study, researchers found that Dicyclomine HCL helped relieve abdominal pain and promoted better bowel movements. However, the drug is mostly used to alleviate colicky-type pain due to muscle spasms associated with irritable bowel syndrome.

7. Will Dicyclomine Hydrochloride make you sleepy?

One of the known side effects of Dicyclomine Hydrochloride is drowsiness and light-headedness. This is why it is not recommended for someone on the drug to drive cars or operate heavy machinery until they know what effect the drug has on them.

8. Can you take Dicyclomine Hydrochloride on an empty stomach?

Dicyclomine HCL should be taken on an empty stomach and 30 minutes to 1 hour before a meal. Do consult a doctor if you face any side effects such as abdominal bloating, mental confusion, or mood changes.

9. Can Dicyclomine Hydrochloride make you lose weight?

Dicyclomine Hydrochloride does not make you lose weight. Dicyclomine Hydrochloride is a prescription drug, which belongs to a class of medication known as anticholinergics or antispasmodics. It is used in the treatment of irritable bowel syndrome or IBS.

10. What medication should not be taken with dicyclomine?

Dicyclomine Hydrochloride can have serious interactions with medication gastrointestinal motility, opioids, growth hormone, antipsychotics, antihistamines and medications that cause sedation, muscle relaxants, some seizure medications. Consult your healthcare professional for more information.

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Dicyclomine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Dicyclomine is used to treat a certain type of intestinal problem called irritable bowel syndrome. It helps to reduce the symptoms of stomach and intestinal cramping. This medication works by slowing the natural movements of the gut and by relaxing the muscles in the stomach and intestines. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.This medication must not be used by children younger than 6 months old because of the risk of serious side effects.

How to use Dicyclomine HCL

Take this medication by mouth with or without food as directed by your doctor, usually 4 times a day. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Mix the dose of liquid with an equal amount of water before taking it.

Antacids lower the absorption of dicyclomine. Do not take this medication at the same time as antacids. If you are taking an antacid, take it after meals and take dicyclomine before meals.

The dosage is based on your age, medical condition, and response to treatment.

Do not increase your dose or take this drug more often without your doctor’s approval. Your condition will not improve any faster and the risk of serious side effects may increase.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Dizziness, drowsiness, lightheadedness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. To relieve dry eyes, consult your pharmacist for artificial tears or other eye lubricants.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: decreased sweating, dry/hot/flushed skin, fast/irregular heartbeat, loss of coordination, trouble speaking, mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement), difficulty urinating, decreased sexual ability.

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking dicyclomine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, little/no stomach acid, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), myasthenia gravis, liver problems, kidney problems.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, fast heartbeat, and urination problems. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. The manufacturer recommends that you do not breast-feed while using this drug. Consult your doctor for more details.

Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: potassium tablets/capsules, drugs that are affected by slowed gut movement (such as pramlintide).

Dicyclomine may affect the absorption of other products such as levodopa, certain azole anti-fungal drugs (ketoconazole, itraconazole), slowly-dissolving forms of digoxin, among others. If you are taking either ketoconazole or itraconazole, take it at least 2 hours before dicyclomine.

Many other drugs that also cause dry mouth and constipation may interact with anticholinergics/antispasmodics such as dicyclomine. Tell your doctor or pharmacist about all the products you take, including: other anticholinergic drugs (such as atropine, glycopyrrolate, scopolamine), other antispasmodic drugs (such as clidinium, propantheline), belladonna alkaloids, certain drugs used to treat Parkinson’s disease (such as trihexyphenidyl), certain drugs used to treat irregular heart rhythms (such as disopyramide, quinidine), MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenothiazines (such as chlorpromazine), tricyclic antidepressants (such as amitriptyline).

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or a fast heartbeat. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including gastric secretion tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Dicyclomine HCL interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: large pupils, hot/dry skin, fever, severe dizziness, severe thirst, difficulty swallowing, mental/mood changes (such as confusion, unusual excitement), fast/irregular heartbeat, muscle weakness, inability to move (paralysis), slowed breathing, fainting, seizures.

Do not share this medication with others.

Management of digestive disorders may include lifestyle changes such as stress reduction programs, exercise, stopping smoking, and dietary changes, in addition to medication. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Keep all medical appointments so that your doctor can periodically monitor your progress and check for side effects. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

dicyclomine 20 mg tablet

Color: blueShape: roundImprint: M D6

This medicine is a blue, round, tablet imprinted with “M D6”.

dicyclomine 20 mg tablet

Color: blueShape: roundImprint: LAN 1282

This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

dicyclomine 10 mg capsule

Color: blueShape: oblongImprint: LANNETT 0586

This medicine is a blue, round, tablet imprinted with “M D6”.

dicyclomine 10 mg capsule

Color: blueShape: oblongImprint: LAN 0586

This medicine is a blue, round, tablet imprinted with “M D6”.

dicyclomine 10 mg/5 mL oral solution

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This medicine is a blue, round, tablet imprinted with “M D6”.

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Color: dark blueShape: oblongImprint: WATSON 794 10 mg

This medicine is a blue, round, tablet imprinted with “M D6”.

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Color: blueShape: oblongImprint: West- ward 3126

This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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This medicine is a blue, round, tablet imprinted with “M D6”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

What is Trigan D? Its effect on the body

A common medicine – Trigan D, when the dosage increases, it begins to act like a drug. Tablets have a versatile effect on the body. They simultaneously anesthetize and have anti-vasospasm properties. Trigan D is sold both in the form of tablets and in the form of a solution.

Today there are no difficulties in purchasing drugs. Drugs that cannot be bought in pharmacies are easily obtained in other ways – via the Internet, distributors in universities, on the streets. It is enough to transfer money to a bank card and find a “bookmark” in the place indicated by the supplier. But illicit substances are not always used as drugs. Often, addiction arises from taking completely legal medications. They are available in pharmacies and available by prescription. And sometimes – and without it.

The result of taking Trigan D in the dose recommended by the doctor is a quick and effective elimination of pain. Exceeding the dosage entails completely different consequences.

Trigan D: effects on the body

Contains paracetamol and dicycloverine. The drug causes a feeling of euphoria, has hallucinogenic properties. The strongest antispasmodic causes blockage of receptors, which leads to the appearance of a trip.

Few of the young generation who use Trigan D most often know that large doses of paracetamol destroy the liver. In Trigan, there is a huge amount of this substance and taking the drug in high dosages will certainly cause the effects of toxins on the internal organs. 5-6 tablets taken at a time will cause serious damage to the liver.

What is Trigan D

Why produce such hazardous drugs? Trigan is a medical remedy used to relieve spasms, pain relief, and sedation. Tablets have a prolonged powerful action, therefore they are used to relieve acute and severe pain – renal and hepatic colic, with irritable bowel syndrome, dysmenorrhea, pylorospasm. A doctor can also prescribe Trigan for a severe cold as an antipyretic, if other drugs do not have the desired effect.

If at small doses the drug causes pleasant relaxation and calmness, then when they are exceeded, on the contrary, irrepressible energy, hallucinations, trips, which are not inferior in intensity to those caused by the use of synthetic drugs.

Features of the effect of Trigan on the body

The onset of the effect of Trigan D on the body becomes noticeable 30 minutes after taking the drug. After 2 hours, the effect reaches its peak and becomes as strong as possible. What happens to the person who has taken the substance? He begins to see hallucinations, unrealistic pictures, can communicate with “imaginary friends.” In some cases, addicts see happy and funny pictures, in others they get into a terrifying and frightening virtual environment.

In many ways, the effect of taking Trigan tablets depends on the individual characteristics of the organism. For this reason, sometimes even a small dose of the drug can cause nightmarish hallucinations, panic, provoking dangerous actions on the part of the patient.

The hallucinogenic effect of Trigan D is the result of exposure to dicycloverine. Often, in order to obtain the most powerful result from taking the drug, the substance is isolated from the composition of the funds and sold in the form of an extract.

Why is addiction to Trigan D dangerous? Unfortunately, teenagers, who most often fall victim to the drug, do not think about what is happening to their body, more and more plunging into addiction. And a terrible thing happens – liver failure, the development of mental illness, the risk of developing a coma increases at times.

How to help a sick person

How to understand that a loved one needs help? Symptoms of an overdose of Trigan D are immediately noticeable:

  • very severe chills up to fever;
  • convulsions, paralysis;
  • severe drowsiness;
  • nausea, vomiting;
  • pain in the gastrointestinal tract;
  • auditory and visual hallucinations.

Failure to provide assistance to the patient leads to the development of necrosis of the liver and kidneys, resulting in death. Simple analgesics can cause a quick and painful death.

What to do? First of all, accept a simple fact – you cannot cope with the dependence on Trigan D on your own. The help of specialists is needed, and it should be versatile. Intervention requires both the physical condition of the patient and psychological dependence.

Trigan D is as addictive as cocaine, heroin, amphetamines. Heart-to-heart conversations will not help solve the problem – the treatment will take a long time and considerable strength.

Drug addiction treatment at the Novaya Zhizn medical center will help solve the problem of drug addiction from Trigan D in the most effective way. The specialists of the clinic will carry out all the necessary procedures for the rapid cleansing of the body from traces of the drug, work out the psychological aspects of addiction, and help you learn how to live without hallucinogenic substances. Complex treatment gives the most effective result.

Dicyclomine | tor4 – here about the culture of consumption and the whole truth about drugs!

Dicyclomine is an anticholinergic (tertiary amine) that blocks muscarinic receptors. Dicyclomine is known as dicycloverine hydrochloride. Dicycloverine contains 72 percent of the anti-muscarinic potency of atropine. It was invented in the USA in 1947.

Chemical compound:
IUPAC 2-(diethylamino)ethyl bi(cyclohexane)-1-carboxylate
Gross
formula: C19h45NO2
Mol.
mass: 309.487 g/mol
CAS 77-19-0
PubChem: 3042
DrugBank: APRD00113
Classification: ATC A03AA07
Pharmacokinetics: Plasma protein binding >99%
Half-life: 5 hours

Pharmacodynamics and clinical use

Pharmacological action: anticholinergic, myotropic , antispasmodic. Eliminates spasm of smooth muscles and reduces the pain syndrome caused by it.
Animal studies (in vitro studies using isolated guinea pig small intestine) show that the effect is mediated by two mechanisms: firstly, a specific anticholinergic effect on acetylcholine receptor sites, similar to that of atropine (antimuscarinic activity), secondly direct effect on smooth muscles, as evidenced by the ability of dicycloverine to block bradykinin- and histamine-induced spasms (atropine does not change the response to these two agonists). In in vivo studies in cats and dogs, dicycloverine was approximately equally effective against acetylcholine and barium chloride induced intestinal spasms. The absence of a significant effect of dicycloverine on the pupil was shown (in tests for evaluating mydriatic effects in mice, the activity was approximately 1/500 of the activity of atropine), as well as on the secretion of the salivary glands (in studies in rabbits, it showed 1/300 of the activity of atropine).

Interaction with other medicinal products (PM): Effects of dicycloverine, incl. side effects, may enhance drugs with anticholinergic activity: amantadine, class I antiarrhythmics (eg quinidine), antihistamine drugs, antipsychotic drugs (eg phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetics, tricyclic antidepressants. Anticholinergic drugs counteract the effect of antiglaucoma drugs. In the presence of elevated intraocular pressure, anticholinergic drugs can be dangerous when used simultaneously with corticosteroids; may affect the absorption of digoxin in the gastrointestinal tract and, as a result, increase the concentration of digoxin in the blood serum; may counteract the effects of substances that alter gastrointestinal motility (metoclopramide). Antacids can affect the absorption of anticholinergic drugs, so their combined use should be avoided. Inhibition of hydrochloric acid secretion by anticholinergic drugs counteracts the action of substances used to treat achlorhydria or test gastric secretion.
In particular, dicyclomine is used to treat intestinal motility, a symptom of irritable bowel syndrome (also known as colon spasms). It relieves muscle spasms and spasms in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells (smooth muscle relaxant). Its effectiveness as a drug against urinary incontinence is being investigated.

Dosage:
Single and daily doses depend on the type of pathology and individual characteristics. The drug is recommended to be taken only after consultation with your doctor. Usually, the drug is prescribed in the following dosages:
Oral: Initial dose 80 mg/day (4 equal doses), adjusted to 160 mg/day.
Intramuscular: 20 mg 4 times a day.
IV: Not used.

Contraindications and side effects

Contraindications: hypersensitivity; intestines; use may contribute to the appearance or exacerbation of such a serious complication as toxic megacolon), peptic ulcer of the stomach and duodenum, reflux esophagitis, unstable conditions of the cardiovascular system, acute bleeding, glaucoma, myasthenia gravis, children’s age (up to 6 months).

Restrictions for use: autonomic neuropathy, impaired liver and kidney function (decreased excretion by the kidneys may increase the risk of side effects), tachycardia, incl. with hyperthyroidism (possibly increased), hypertension (possible exacerbation), heart disease (including coronary artery disease, congestive heart failure, tachyarrhythmia), hiatal hernia, prostatic hypertrophy.

Use during pregnancy and lactation: during pregnancy, use only if necessary. There are no adequate and well-controlled studies in humans. Contraindicated in breastfeeding (diccycloverine hydrochloride has been reported to be excreted in breast milk; respiratory distress syndrome may develop in breastfed children).

Side effects: can cause a wide range of anticholinergic side effects, which are conventionally divided into two types: mental (confusion, delirium, short-term memory impairment, disorientation, decreased attention (including driving vehicles)) and physical (dry mouth, constipation, drop in blood pressure, urinary retention (especially in men with prostatic hyperplasia), decreased visual acuity, reduced sweating against the background of elevated body temperature, sexual disorders, deterioration in the condition of patients suffering from glaucoma (due to increased intraocular pressure ), nausea
Data on the potential carcinogenicity and mutagenicity of dicycloverine hydrochloride in humans are not available. Long-term animal studies evaluating the potential carcinogenicity of dicycloverine hydrochloride have not been conducted. In studies in rats, when administered at doses up to 100 mg / kg / day, dicycloverine hydrochloride did not have a dangerous effect on reproduction, conception and childbirth.

Overdose: Symptoms: headache, nausea, vomiting, prolonged blurred vision, dilated pupils, fever, dry skin, dizziness, dry mouth, difficulty swallowing, CNS stimulation. Perhaps curariform action i.e. neuromuscular blockade leading to muscle weakness and paralysis. In some cases, premature death (death) has been observed after taking a single dose of 200 mg or more. If you have symptoms of an overdose and / or mistakenly taking the drug, you should immediately consult a doctor. In Egypt, Brazil, Ukraine, dicyclomine is popular as a drug.

Brand names

In America it is sold under the brand names Bentyl, Byclomine, Dibent, Di-Spaz, Dilomine.
In the UK it is sold under the brand names Merbentyl (containing 10 mg dicycloverine) and Merbentyl 20 (containing 20 mg dicycloverine).