Levocetirizine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

How to use Levocetirizine DIHYDROCHLORIDE

If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

This medication is taken by mouth with or without food, usually once daily in the evening.

If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.

If your condition does not get better or if it gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Drowsiness, tiredness, and dry mouth may occur. Fever or cough may also occur, especially in children. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty urinating, weakness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking levocetirizine, tell your doctor or pharmacist if you are allergic to it; or to cetirizine; or to hydroxyzine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (such as due to an enlarged prostate), kidney disease.

This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as diphenhydramine, promethazine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Levocetirizine is very similar to hydroxyzine and cetirizine. Do not use these medications while using levocetirizine.

This medication may interfere with certain laboratory tests (including allergy skin testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Levocetirizine DIHYDROCHLORIDE interact with other drugs you are taking?

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness. In children, mental/mood changes (such as restlessness, agitation) may occur before drowsiness.

Keep all regular medical and lab appointments.

If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: APO L 5

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: S G 1 36

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: G G

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 2.5 mg/5 mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: I 12

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: M 17

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 2.5 mg/5 mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: 9 3 7701

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 2.5 mg/5 mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: roundImprint: 161 H

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: L9CZ 5

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 5 mg tablet

Color: whiteShape: ovalImprint: S

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 2.5 mg/5 mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

levocetirizine 2.5 mg/5 mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, scored, film-coated, tablet imprinted with “APO” and “L 5”.

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Drug Survey

Are you currently using Levocetirizine DIHYDROCHLORIDE?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Side effects, dosage, uses, and more

1. Prescription levocetirizine oral tablet is available as both a generic and a brand-name drug. Brand name: Xyzal.
2. Prescription levocetirizine comes as an oral tablet and an oral solution. Both forms are also available in over-the-counter forms.
3. Prescription levocetirizine oral tablet is used to treat the symptoms of seasonal and year-round allergies. It’s also used to relieve itching caused by hives.

Prescription levocetirizine oral tablet is available as the brand-name drug Xyzal. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Prescription levocetirizine comes as an oral tablet and an oral solution. Both forms are also available in over-the-counter versions.

Why it’s used

Prescription levocetirizine oral tablet is used to treat the symptoms of seasonal and year-round allergies. It’s also used to relieve itching caused by hives (patches of red, swollen, itchy skin).

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

How it works

Levocetirizine belongs to a class of drugs called antihistamines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Levocetirizine works by blocking the release of a chemical called histamine from the cells in your body. This helps relieve symptoms of allergies, such as sneezing, runny nose, and red, watery, itchy eyes. This drug also helps relieve itching caused by hives.

Levocetirizine oral tablet may cause drowsiness. This occurs more often during the first few hours after you take the drug. It may also cause other side effects.

More common side effects

Side effects of levocetirizine can vary according to age.

In adults and children ages 12 and older, the more common side effects that can occur include:

• tiredness
• dry mouth
• sore throat
• nasopharyngitis (redness and inflammation in the nose and throat)

In children ages 6–11 years, the more common side effects that can occur include:

• fever
• cough
• sleepiness
• nose bleeds

In children ages 1–5 years, the more common side effects that can occur include:

• fever
• diarrhea
• vomiting
• ear infections

In children ages 6–11 months, the more common side effects that can occur include:

• diarrhea
• constipation

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Allergic reactions. Symptoms can include:
  • rash
  • itching
  • hives
  • swelling of your lips, tongue, face, or throat
• Kidney problems. Symptoms can include:
  • trouble urinating
  • changes in the amount you urinate
  • blood in your urine
• Blurry vision

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Levocetirizine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with levocetirizine are listed below.

Asthma or COPD drug

Theophylline is used to treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). Using this drug with levocetirizine may cause increased amounts of levocetirizine in your body. This raises your risk of side effects.

HIV drug

Ritonavir is used to treat HIV. Using this drug with levocetirizine can cause increased amounts of levocetirizine in your body. This raises your risk of side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This dosage information is for levocetirizine oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Levocetirizine

• Form: Oral tablet
• Strengths: 5 mg

Brand: Xyzal

• Form: Oral tablet
• Strengths: 5 mg

Dosage for seasonal and year-round allergies

Adult dosage (ages 18–64 years)

The typical dosage is one 5-mg tablet once per day in the evening.

Child dosage (ages 12–17 years)

The typical dosage is one 5-mg tablet once per day in the evening.

Child dosage (ages 6–11 years)

The typical dosage is one half-tablet (2.5 mg) once per day in the evening.

Child dosage (ages 5 years and younger)

Dosage for levocetirizine oral tablet hasn’t been established for children younger than 6 years of age. (The oral solution is recommended for children ages 6 months to 5 years.)

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for chronic itching

Adult dosage (ages 18–64 years)

The typical dosage is one 5-mg tablet once per day in the evening.

Child dosage (ages 12–17 years)

The typical dosage is one 5-mg tablet once per day in the evening.

Child dosage (ages 6–11 years)

The typical dosage is one half-tablet (2.5 mg) once per day in the evening.

Child dosage (ages 5 years and younger)

Dosage for levocetirizine oral tablet hasn’t been established for children younger than 6 years of age. (The oral solution is recommended for children ages 6 months to 5 years.)

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special dosage considerations

The typical dosages for people with kidney problems include:

• Mild kidney disease: 2. 5 mg once per day.
• Moderate kidney disease: 2.5 mg once every other day.
• Severe kidney disease: 2.5 mg twice per week (taken once every 3–4 days).
• End-stage kidney disease and on hemodialysis: Do not take levocetirizine.

Warnings

Don’t take more than the recommended dose of levocetirizine. There is an increased risk of sleepiness at higher doses.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Levocetirizine oral tablet is used for short-term treatment of seasonal allergies and long-term treatment of chronic itching. It comes with risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: If you’re taking this drug to treat allergy symptoms, these symptoms may not be controlled or may get worse. These symptoms can include sneezing, runny nose, and red, watery, itchy eyes.

If you’re taking this drug to treat itching caused by hives, this itching may not be controlled or may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• increased drowsiness (adults)
• agitation and restlessness, followed by drowsiness (children)

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: If you’re taking this drug to treat allergy symptoms, these symptoms should improve. These can include sneezing, runny nose, and red, watery, itchy eyes.

If you’re taking this drug to treat itching caused by hives, this itching should improve.

As with all medications, the costs of levocetirizine can vary.

Keep these considerations in mind if your doctor prescribes levocetirizine oral tablet for you.

General

• You can take this drug with or without food.
• You should take this drug in the evening. This can help prevent daytime drowsiness. You can cut or crush the tablet.
• Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.

Storage

• Store this drug at room temperature between 68°F and 77°F (20°C and 25°C).
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport x-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may monitor your kidney function to make sure it’s safe for you to take this drug. If your kidney function gets worse, your doctor may have you stop taking this drug. They may switch you to a different medication.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Increased tiredness warning: This drug can cause tiredness. Don’t drive, use machinery, or do other dangerous activities until you know how this drug affects you. Also, don’t drink alcohol or take other medications that may cause you to feel tired. It could make your tiredness worse.

Levocetirizine oral tablet comes with several warnings.

Allergy warning

This drug can cause a severe allergic reaction. Symptoms can include:

• rash
• itching
• hives
• swelling of your lips, tongue, face, or throat

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or cetirizine before. Taking it again could be fatal (cause death).

Warnings for people with certain conditions

For people with kidney disease: More of this drug may stay in your body for a longer time. This raises your risk of side effects. Don’t use this drug if you have severe kidney problems or are on hemodialysis.

Warnings for other groups

For pregnant women: This drug is a category B pregnancy drug. That means two things:

1. Research in animals has not shown a risk to the fetus when the mother takes the drug.
2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed. Call your doctor if you become pregnant while taking this drug.

Women who are breastfeeding: This drug may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: It isn’t known if this drug is safe or effective for children younger than 6 months of age.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

October 05, 2017

REPORT

October 05, 2017 for doctors – dermatovenerologists, cosmetologists and doctors of other specialties, in accordance with the order of the Minister of Health of the Samara Region dated 01.10.2017 . No. 776-r, the public organization “Samara Regional Association of Doctors” together with the Ministry of Health of the Samara Region and the Samara State Medical University held a scientific and practical conference on the topic: “Order” for the provision of cosmetic care to the population of the Samara Region. Standards, protocols and algorithms of modern therapeutic approaches in the practice of dermatovenereologists and cosmetologists” within the framework of the twenty-eighth educational week, as well as the XII specialized interregional exhibition “Sharm-PROFI”.

The chief freelance specialist of the Ministry of Health of the Samara Region in dermatovenereology and cosmetology, chief physician of the Samara Regional Dermatovenerologic Dispensary, Doctor of Medical Sciences, Professor Shakurov I.G.

Orlov E.V. , Doctor of Medical Sciences, Professor, Head of the Department of Skin and Venereal Diseases, Samara State Medical University of the Ministry of Health of Russia, spoke about professional retraining, advanced training for a cosmetologist.

Then there were 3 reports.

1. “Adjuvant therapy of acne as an integral part of the treatment protocol”

Kruglova Larisa Sergeevna, Professor, MD, Head of the Department of Dermatovenereology and Cosmetology of the Central State Medical Academy of the UDP RF.

Acne is a chronic disease in which the skin barrier is damaged. Most acne medications address up to 3 of the 4 pathogenic causes of acne. To restore the skin barrier, care for the skin and minimize the adverse effects of acne drug therapy, it is necessary to use specialized concomitant therapy products that provide gentle cleansing, sebum control and an acceptable cosmetic effect. It is important that these products are non-comedogenic, well tolerated and have a balanced composition.

2. “Modern aspects of topical therapy of steroid-sensitive dermatoses in accordance with clinical guidelines”

Matushevskaya Elena Vladislavovna, MD, Professor of the Department of Dermatovenereology and Cosmetology FSBEI DPO IPK FM BA.

More than 50 years have passed since the Nobel Prize Ph. Hench and E. Kendall for introducing glucocorticosteroid hormones into clinical practice. The pronounced anti-inflammatory effect and high efficiency have made this group of drugs one of the most commonly used drugs.

The development of glucocorticosteroid therapy has come a long way from the creation of the first topical preparations with a large number of side effects to the synthesis of steroids with high efficiency and minimal local adverse reactions. In this regard, of particular interest is 0.1% methylprednisolone aceponate, which has been used in clinical practice since 1994.

Methylprednisolone aceponate belongs to the medium strength class. This is a new generation non-halogenated topical glucocorticosteroid with a proven combination of high activity and minimal risk of systemic and local adverse reactions, even with long-term use. The almost complete absence of systemic effects is due to the insignificant penetration of the drug from the skin into the blood, a short half-life in circulating blood, as well as strong binding to the transport protein transcortin and subsequent inactivation in the liver.

Of all existing glucocorticosteroids, methylprednisolone aceponate has the lowest therapeutic index, that is, a good ratio of the risk of side effects and therapeutic efficacy. The drug does not affect the level of endogenous cortisol, which is especially important in pediatrics, since children have a higher absorption of drugs due to a larger ratio of skin area to body weight. In addition, they have a weaker system of metabolism of exogenous steroids than adults.

Practitioners will be interested in a new line of domestic products based on 0.1% methylprednisolone aceponate for topical therapy of steroid-sensitive dermatoses: within the framework of import substitution programs.

3. “The role and place of antihistamines in the treatment of allergic dermatosis”

Matushevskaya Elena Vladislavovna, Doctor of Medical Sciences, Professor of the Department of Dermatovenereology and Cosmetology FGBOU DPO IPK FMBA.

Antihistamines (AHPs) are widely used in dermatology and are first-line drugs for many diseases. These dermatoses (dermatitis, urticaria, pruritus, eczema, scabies, skin lymphomas), despite differences in pathogenesis and clinical manifestations, are united by one symptom – itching.

Itching is defined as a sensation that causes a conscious or reflex desire to scratch. The sensation of itching is directly related to the skin and to the production of humoral factors, the spectrum of which is different in different pathologies. In many dermatoses (contact dermatitis, toxicoderma, urticaria), itching is caused by the release of histamine. Accordingly, antihistamines are the first line of therapy for these dermatoses.

The main target of antihistamine action is the blockade of the inflammatory process caused by the binding of IgE antibodies to the allergen. As a result of the action of antihistamines, itching and swelling are reduced. Second-generation antigens, unlike first-generation antigens, practically do not penetrate the BBB and do not cause a sedative effect. II generation antihistamines are able to selectively block h2-receptors, quickly have a clinical effect within 24 hours, practically do not cause tachyphylaxis and have a high safety profile. Levocetirizine occupies a special place among the drugs of the second generation. Along with all the advantages of non-sedating antihistamines, levocetirizine has not only high selectivity for H1 receptors, but also the fastest and longest antihistamine effect when taken once a day. There is a high adherence of patients to the drug due to the high safety profile and the possibility of long-term use of levocetirizine.

Generic levocetirizine Allerway (Dr. Reddy’s Laboratories) is available on the domestic market. Allerway is bioequivalent to the original levocetirizine. It has a wide range of indications and is recommended for the treatment of pollinosis, symptoms of allergic rhinitis and allergic conjunctivitis, urticaria and other allergic dermatoses accompanied by itching and rashes.

Gribanov A.V., Vice-President of the “National Council of the Beauty Industry”, head of the section of cosmetologists at the Samara branch of the Russian Association of Dermatovenereologists and Cosmetologists also made a report on the topic “New trends in the development of lawmaking in the beauty industry. What should a law-abiding cosmetologist do?

The final speech was made by the chief freelance specialist of the Ministry of Health of the Samara region in dermatovenereology and cosmetology, chief physician of the Samara Regional Dermatovenerologic Dispensary, Doctor of Medical Sciences, Professor Shakurov I.G., in which he thanked everyone those present for their participation and wished them success in their future work.

06/16/2017

Vol 5, No 1 (2008)

open access

access granted

Subscription or Fee Access

Articles

PROTIVOALLERGIChESKIE SVOYSTVAEKSTRAKTOV OVSA RHEALBA

Gushchin I.S.

Abstract

Data obtained on cellular pharmacological models indicate that the polyphenol
Zero extracts of oats Rhealba have an anti-inflammatory effect on important pathophysio-
logical links involved in the pathogenesis of atopic dermatitis. These extracts restore
function of the epidermal barrier and eliminate skin dryness, which leads to a decrease in skin itching,
scratching and the risk of infection. The use of oat extracts in the clinical setting suppresses
relieves manifestations of atopic dermatitis, including itching and scratching. Clinical trials showing
emollients containing Rhealba oat extract are highly effective
steroid-substituting agents and are considered as first-line agents in the management of patients
atopic dermatitis, strongly recommended by international and national consensus
telny documents and manuals.

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Russian Journal of Allergy . 2008;5(1):5-11

(Rus)

(JATS XML)

GRIBY RODA MALASSEZIA I ATOPIChESKIYDERMATIT

Mokronosova M.A.

Abstract

Data on the classification of fungi of the genus Malassezia, physiological and biochemical
properties of lipophilic fungi, features of the immune response to yeast in patients with atopic4
kim dermatitis.

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Russian Journal of Allergy . 2008;5(1):12-18

(Rus)

(JATS XML)

KOZhNAYa ChUVSTVITEL’NOST’K ATsETILKhOLINU U BOL’NYKh ATOPIChESKIMDERMATITOM (ATD) I POLLINOZOM

Grebenchenko E. I., Gushchin I.S., Fedenko E.S.

Abstract

Purpose. Assess skin sensitivity to acetylcholine (ACC) in patients with AD and patients with hay fever
zom and the influence of the sensitization factor on it.
Materials and methods. We examined 8 patients with AD with household and pollen sensitization, 10 pain>
hay fever and 8 healthy individuals. Microcirculation in two symmetrical areas intact>
of the skin of the forearms was evaluated according to the results of laser Doppler flowmetry in standard
conditions. Then, 20 µl of a 0.5 M ACH solution was injected intradermally into the back surface of the left
shoulders (for control, it was injected into the symmetrical point of the right forearm 0.9% NaCl solution in the same
volume) and within 20 minutes the reaction to ACH was evaluated by the appearance of a local sensation (according to
visual analog scale) and measurement of microcirculation (in the area 1 cm proximal to the
administration of ACH).
Results. It was found that at the injection site of ACH, patients with AD experienced a feeling of itching, and persons
suffering from hay fever, and healthy – tingling and burning. The duration of this response is
answered: patients with AD > patients with hay fever > healthy. Microcirculation changes in response
on ACH in patients with AD in the acute stage were more pronounced than in the remission stage, and in pain>
hay fever in the stage of remission is more pronounced than in healthy individuals.
Conclusions. The nature of the reaction to ACH in patients with AD (itching sensation) is different from that in patients with gender
linosis and healthy individuals (tingling and burning sensation). This difference is not related to sensitization>
tion as such and can explain the nature of the main symptom of AD – pruritus.

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Russian Journal of Allergy . 2008;5(1):19-23

(Rus)

(JATS XML)

KLINIChESKIE FORMY I PRINTsIPYTERAPII KhRONIChESKIKh KRAPIVNITs U DETEY

Pampura A.N., Solovey T.N.

Abstract

The article reflects approaches to the treatment of various forms of chronic urticaria in children.

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Russian Journal of Allergy . 2008;5(1):24-33

(Rus)

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Effektivnost’ tsiklosporinapri khronicheskoy autoimmunnoykrapivnitse

Zemskaya E.N.

Russian Journal of Allergy . 2008;5(1):34-36

(Rus)

(JATS XML)

Allergicheskiy rinit i ego vliyaniena astmu: rol’ an tigistaminn ykhpreparatov v lechenii i profilaktike

Astaf’eva N.G.

Russian Journal of Allergy . 2008;5(1):37-48

(Rus)

(JATS XML)

retsiVOZMOZhNOSTII PERSPEKTIVY DIAGNOSTIKIALLERGIChESKOGO KONTAKTNOGO DERMATITAV SOVREMENNOY PRAKTIKE

L’vov A.N., Fedenko E.S., Ivanov O.L., Belousova T.A., Polunina S.S.

Abstract

The use of modern allergological test systems significantly complements our ideas.
information about both the epidemiology and the clinic of allergic contact dermatitis. Among modern
application test systems stands out AllerTest – a thin-layer application test system,
containing a standardized set of completely ready-to-use allergens in 24 labels.
AllerTest includes allergens that cause at least two-thirds of allergic reactions.
tact dermatitis, and was developed taking into account its pathogenetic mechanisms. The article provides
assessment of the possibilities and prospects for the use of AllerTest in a wide medical practice.

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Russian Journal of Allergy . 2008;5(1):49-55

(Rus)

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Allergicheskiy rinit

Pol’ner S.A., Boykova N.B.

Abstract

Allergic rhinitis is a widespread disease. Diagnose allergies
rhinitis and adequate therapy can be prescribed already at the outpatient stage, not by allergists,
and doctors of other specialties. Cytological examination plays an important role in establishing the diagnosis.
following the material taken from the nasal mucosa. And the study of the cellular composition, in addition to the clinical
pictures, helps in the choice of therapy. After a 2-week course of intranasal use of Flixonase
significantly decreased the number of eosinophils and inflammatory cells in the nasal mucosa, which was
indicator of the effectiveness of the treatment of allergic rhinitis.

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Russian Journal of Allergy . 2008;5(1):56-61

(Rus)

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Levotsetirizin v l echenii khronicheskoyidiopaticheskoy krapivnitsy:randomizirovannoe dvoynoe slepoeplatsebo-kontroliruemoe issledovanie

Nettis E., Kolanardi M.S., Barra L., Ferrannini A., Vakka A., Tursi A.

Abstract

Introduction. Chronic urticaria is a common skin disease. At the same time, worries
levania, disability is lost due to the persistence of clinical manifestations, unpredictable course and
negative impact on quality of life.
Target. To find out whether levocetirizine is effective in the treatment of chronic idiopathic urticaria.
Methods. conducted a randomized, double-blind, placebo-controlled study on 106 patients
patients diagnosed with chronic idiopathic urticaria. For a 1-week simple blind introductory
period (baseline) was followed by a 6-week double-blind active treatment period. Patients were wounded
housed in groups receiving treatment once a day according to one of the following schemes: (a) levocetirizine 5
mg orally or (b) placebo orally. And the study ended after another simple blind 1-week
washout period with placebo.
Results. The evaluable population included 100 patients. Levocetirizine once administered
per day is well tolerated and effective in the treatment of symptoms of chronic idiopathic urticaria
and improve the quality of life of the patient. Levocetirizine was superior to placebo in reducing mean total
assessment of symptoms, manifestation of individual symptoms, number of daily episodes and number of papules, total
severity of symptoms, and improved quality of life. The expected beneficial effect of levocetiri-
zina lasted only during the active study, while at follow-up after
At the end of the active study, there was a significant deterioration in all studied parameters
of this study (week 7).
Conclusion. Overall evaluation shows that levocetirizine 5 mg once daily is effective
drug for patients with chronic idiopathic urticaria, as its action provides
quick and satisfactory control of symptoms and subjective manifestations of the disease, although
For me, it is limited by the duration of treatment.

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Russian Journal of Allergy . 2008;5(1):62-68

(Rus)

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Effektivnost’ Rinoklenila u bol’nykhsezonn ym (intermittiruyushchim)allergicheskim rinitom

Il’ina N.I., Erokhina S.M., Emel’yanov A.V., Chachaeva L.V., Khanferyan R.A., Savchenko E.A., Pavlova K.S.

Abstract

Target. To evaluate the efficacy and safety of the use of beclomethasone dipropyl metered dose spray.
onate (rhinoclenil) in patients with pollinosis (seasonal allergic rhinitis (AR)) taking into account changes
quality of life (QoL) of patients.
Materials and methods. The study included patients suffering from hay fever with clinical
manifestations in the form of rhinitis and / or conjunctivitis, with a disease experience of at least 2 years. Assessed
the dynamics of the main symptoms of AR and QoL indicators, as well as the need for symptomatic therapy
(topical decongestants) at baseline and during therapy.
Results.