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Is meloxicam mobic. The Comprehensive Guide to Meloxicam (Mobic): Uncovering the Side Effects and Safety Concerns

by alexxlab

What are the potential side effects of meloxicam (Mobic)? How can long-term use impact health? Get the answers to these and other crucial questions about this prescription NSAID medication.

Meloxicam (Mobic): Understanding the Drug and Its Uses

Meloxicam, commonly known by its brand name Mobic, is a prescription nonsteroidal anti-inflammatory drug (NSAID) approved by the Food and Drug Administration (FDA) in the United States in 2000. This medication is primarily used to alleviate pain, inflammation, tenderness, and stiffness associated with conditions such as rheumatoid arthritis and osteoarthritis.

Common Side Effects of Meloxicam (Mobic)

While many of the side effects experienced when taking meloxicam as prescribed are not considered serious, it is important to be aware of them and consult a healthcare provider if they persist or become troublesome. Some of the more common side effects of meloxicam include:

  • Diarrhea
  • Gas
  • Heartburn
  • Indigestion

Less frequent side effects may include:

  • Abnormal dreaming
  • Difficulty falling or staying asleep
  • Tiredness
  • Anxiety
  • Mild depression
  • Irritability
  • Confusion
  • Trouble concentrating
  • Appetite changes, especially an increased appetite
  • Stomach pain
  • Nausea/vomiting
  • Bloating
  • Constipation
  • Changes in vision
  • Itchy, burning, or dry eyes
  • Ringing in the ears, or tinnitus
  • Hearing loss
  • Dry mouth
  • Changes in taste
  • Unpleasant or unusual aftertaste
  • Rapid breathing
  • Tingling or pinprick sensations
  • Thinning hair

Dangerous Side Effects of Meloxicam (Mobic)

While many of the side effects associated with meloxicam are not considered serious, there are some that can be dangerous and require immediate medical attention. If a person experiences any of the following symptoms, they should seek emergency medical help by calling 911:

  • Chest pain
  • Shortness of breath
  • Slurred speech
  • Weakness on one side or part of the body

Additionally, if a person experiences any of the following side effects, they should immediately stop taking meloxicam and contact their healthcare provider:

  • Stomach pain
  • Heartburn
  • Bloody vomit
  • Vomit with a coffee-ground appearance
  • Bloody, black, and/or tarry stools
  • Swelling (especially of the throat, tongue, lips, eyes, or face)
  • Trouble breathing or swallowing
  • Rash/blisters/itching
  • Fever
  • Hoarseness
  • Pale skin
  • Fast or irregular heartbeat
  • Nausea
  • Unexplained weight gain
  • Yellowed eyes or skin
  • Pain in the back or upper right part of the stomach
  • Discolored, bloody, or cloudy urine
  • Painful or difficult urination
  • Fatigue
  • Flu-like symptoms

Meloxicam (Mobic) Overdose Symptoms

It is possible to overdose on meloxicam. If a person takes too much of this medication, they should call the poison control helpline at 1-800-222-1222. If they had a seizure, have difficulty breathing, collapsed, or cannot be woken up, they should call 911 immediately. Symptoms of a meloxicam overdose include:

  • Loss of energy
  • Drowsiness
  • Nausea or vomiting
  • Bloody vomit
  • Vomit with a coffee-ground appearance
  • Stomach pain
  • Bloody, black, and/or tarry stools
  • Trouble breathing
  • Seizures
  • Coma

Long-Term Risks of Meloxicam (Mobic) Use

While meloxicam is generally well-tolerated, long-term use of this medication, as well as other NSAIDs, can increase the risk of serious health complications. These include:

  • Stomach or intestinal bleeding, ulcers, or holes
  • Increased risk of heart attack or stroke

Factors that can increase the risk of these complications include being older, consuming large amounts of alcohol, being in poor health, taking other NSAIDs or certain other medications, and long-term use of the medication. It’s important to be aware of the signs and symptoms of these issues, which may include heartburn, stomach pain, vomiting blood, bloody stools, and black/tarry stools. If any of these symptoms occur, it is crucial to stop taking meloxicam and seek immediate medical attention.

Insomnia: A Potential Adverse Effect of Meloxicam (Mobic)

Insomnia is another potential adverse effect associated with the use of meloxicam. Insomnia can have significant impacts on a person’s health and well-being, including decreased cognitive function, increased risk of accidents, and a higher likelihood of developing other health problems. If insomnia persists or becomes problematic, it is important to discuss this with a healthcare provider.

Conclusion

In summary, meloxicam (Mobic) is a prescription NSAID medication used to treat the pain, inflammation, tenderness, and stiffness associated with conditions like rheumatoid arthritis and osteoarthritis. While many of the side effects of this medication are not considered serious, there are some that can be dangerous and require immediate medical attention. Additionally, long-term use of meloxicam, as well as other NSAIDs, can increase the risk of serious health complications such as stomach/intestinal bleeding, ulcers, heart attack, and stroke. Insomnia is another potential adverse effect that should be monitored. It is important for patients taking meloxicam to be aware of the potential side effects and risks, and to communicate openly with their healthcare providers about any concerns or issues that arise.

Side Effects of Meloxicam (Mobic)

Reviewed by: Sophie Stein, MSN

Updated: Feb 17, 2023

Meloxicam (brand name Mobic) is a prescription nonsteroidal anti-inflammatory drug (NSAID). Mobic uses include: treating pain, inflammation, tenderness, and stiffness typically from rheumatoid arthritis or osteoarthritis.

Mobic was approved for use in the United States by the Food and Drug Administration (FDA) in 2000. Unlike opioid medications, meloxicam is not considered addictive. However, meloxicam is sometimes abused because it is mistakenly believed to have opioids in it. The medication does not induce euphoria, but it can lead to serious side effects, especially if taken excessively.

General Side Effects of Meloxicam

Some of the side effects associated with meloxicam are usually not serious. However, you should consult with your healthcare provider if they do not go away on their own or if they are troublesome.

Some of the Meloxicam side effects that are more common include:

  • Diarrhea
  • Gas
  • Heartburn
  • Indigestion

Some of the Meloxicam side effects that are less frequent include:

  • Abnormal dreaming
  • Difficulty falling or staying asleep
  • Tiredness
  • Anxiety
  • Mild depression
  • Irritability
  • Confusion
  • Trouble concentrating
  • Appetite changes, especially an increased appetite
  • Stomach pain
  • Nausea/vomiting
  • Bloating
  • Constipation
  • Changes in vision
  • Itchy, burning, or dry eyes
  • Ringing in the ears, or tinnitus
  • Hearing loss
  • Dry mouth
  • Changes in taste
  • Unpleasant or unusual aftertaste
  • Rapid breathing
  • Tingling or pinprick sensations
  • Thinning hair

Harmful Side Effects of Meloxicam

While many of the side effects from taking meloxicam as prescribed will pass and are not serious, some can be dangerous. The risk of these side effects may go up if a person takes too much meloxicam or uses meloxicam for a long time.

If a person experiences any of the below symptoms, they should get emergency medical help by calling 911:

  • Chest pain
  • Shortness of breath
  • Slurred speech
  • Weakness on one side or part of the body

If a person experiences any of the below side effects, they should immediately stop taking meloxicam and contact their healthcare provider:

  • Stomach pain
  • Heartburn
  • Bloody vomit
  • Vomit with a coffee-ground appearance
  • Bloody, black, and/or tarry stools
  • Swelling (especially of the throat, tongue, lips, eyes, or face)
  • Trouble breathing or swallowing
  • Rash/blisters/itching
  • Fever
  • Hoarseness
  • Pale skin
  • Fast or irregular heartbeat
  • Nausea
  • Unexplained weight gain
  • Yellowed eyes or skin
  • Pain in the back or upper right part of the stomach
  • Discolored, bloody, or cloudy urine
  • Painful or difficult urination
  • Fatigue
  • Flu-like symptoms

Overdose Symptoms

It is possible to overdose on meloxicam. If a person takes too much meloxicam, call the poison control helpline at 1-800-222-1222. If they had a seizure, have difficulty breathing, collapsed, or cannot be woken up, call 911 immediately. Symptoms of an overdose include:

  • Loss of energy
  • Drowsiness
  • Nausea or vomiting
  • Bloody vomit
  • Vomit with a coffee-ground appearance
  • Stomach pain
  • Bloody, black, and/or tarry stools
  • Trouble breathing
  • Seizures
  • Coma

Meloxicam Can Cause Long-Term Harm

All medications have potential side effects. Long-term use of NSAIDs may increase the risk of stomach or intestinal bleeding, ulcers, or holes. Long-term use of non-aspirin NSAIDs may increase the risk of heart attack or stroke.

Bleeding, ulcers, or holes in the stomach or intestines can develop at any time during use of NSAIDs and can be fatal if untreated. People who are older, drink large amounts of alcohol, are in poor health, or are also taking other NSAIDs or certain other medications, as well as people who have been taking NSAIDs for a long time, may be at increased risk of developing these problems. These issues may happen without any warning signs, or they may present with heartburn, stomach pain, vomit with a coffee-ground appearance, bloody vomit, bloody stools and/or black and tarry stools. Contact a healthcare professional right away and stop taking meloxicam if you experience any of those symptoms.

Taking NSAIDs other than aspirin may increase a person’s risk of having a stroke or heart attack, which can be deadly. Long-term use of NSAIDs may increase this risk. People who have recently had a heart attack should not take an NSAID unless their healthcare provider specifically tells them to. Before starting an NSAID, let your health care provider know if you or anyone in your family has or has in the past had heart disease, a stroke, or a heart attack, as well as if you have or have in the past smoked, had high cholesterol, had high blood pressure, or had diabetes. Heart attack or stroke can occur without warning. Call 911 for emergency medical help if you have shortness of breath, chest pain, slurred speech, and/or weakness in one part or side of your body.

Insomnia is a potential adverse effect, as well. Insomnia can cause sleepiness during the day and lack of energy. This can cause serious problems, for instance if a person is driving when drowsy and gets into an accident. It can also lead to feeling depressed, anxious, or irritable, as well as cause difficulty focusing, learning, and remembering.

It is also possible to develop kidney damage from taking meloxicam. However, drug-induced kidney damage is often reversible if the drug causing it is stopped.

Meloxicam use can also lead to liver damage. Studies show that up to 7 percent of people who take meloxicam experience some elevated liver enzymes. This sometimes resolves on its own, even if the person is still taking meloxicam. Symptoms of liver damage may include fatigue, decreased appetite, nausea, yellowing of the skin or eyes, or dark urine.

Some people who take NSAIDs retain water, which can lead to swelling that is uncomfortable or even dangerous, as it can cause heart failure. Fluid retention may also lead to anemia. This swelling, also known as edema, is typically most noticeable in a person’s arms, hands, legs, ankles, and feet.

Women who are pregnant should consult their healthcare provider before beginning a prescription for meloxicam, and women taking meloxicam who think they may have become pregnant should let their healthcare provider know right away. Meloxicam may cause harm to the fetus.

Patients should make sure their healthcare provider is aware of all their past and current health conditions and any use of alcohol, tobacco, or other drugs, as well as all medications, vitamins, and supplements they are taking. This enables the provider to discuss with the patient the risks versus benefits of taking meloxicam, including the risks of possible interactions or adverse effects, and to decide if meloxicam is the right choice for that patient.

Get Help for Substance Abuse Involving Meloxicam or Other Drugs

Meloxicam is not addictive and does not cause feelings of euphoria, but some people may mistakenly believe it is an opioid since it is prescribed for pain. These individuals may try to get high from taking excessive amounts of this medication. The drug is sometimes diverted for illicit distribution, so it sometimes can be obtained through those routes.

People who struggle with substance use problems should seek help. If their addiction is not addressed, it can cause long-term harm to their bodies and minds. Treatment programs can help you overcome addiction. These programs typically include therapy to help people understand their addiction, to develop better coping mechanisms, and to find a healthy routine that does not involve drugs or alcohol.

You aren’t alone. You deserve to get help.

We are here to help you get sober and learn how to stay that way. Laguna Treatment Hospital is located in Orange County within easy reach of the entire Los Angeles metro. We are the premier chemical dependency recovery hospital in the OC. We offer safe medical detox, mental health support, and wellness programs.

Meloxicam | VCA Animal Hospital

What is meloxicam?

Meloxicam (brand names Metacam® Loxicom®, OroCAM®, Rheumocam) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever in dogs and cats. It is indicated for the treatment of osteoarthritis in dogs and cats. Meloxicam is also used to treat pain associated with surgery.

How do I give my pet meloxicam?

Meloxicam is available as an oral liquid, oral spray (spray not available in Canada), injection, or chewable tablets for dogs, but only as an oral liquid or injection for cats. It is also available in pill form (brand name Mobic®, Mobicox®) for human use, which your veterinarian may prescribe ‘off label’ or ‘extra-label’ for large dogs.

Many drugs are commonly prescribed for off label use in veterinary medicine. In these cases, follow your veterinarian’s directions and cautions very carefully.

Your veterinarian will administer the injectable version of the drug.

Before giving the oral liquid, shake the bottle well. Carefully measure the dose as directed by your veterinarian. Chewable tablets should be given as directed by your veterinarian.

Give meloxicam with food to reduce gastrointestinal side effects.

The oral spray is sprayed inside the cheek space. Your veterinarian will provide you with specific instructions for administering the medication.

This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.

What if I miss giving my pet the medication?

If you miss giving your pet a dose, give the next dose as soon as you remember, but if it is closer than 12 hours before the next scheduled dose, either:

  1. skip the dose you missed, give it at the next scheduled time, and continue with the regular dosing schedule, OR
  2. give the missed dose and then wait the recommended interval before giving the next dose (continue giving it regularly at that new time).

Never give your pet two doses at once or give extra doses.

Are there any potential side effects?

Dogs: The most common side effect of meloxicam in dogs is gastrointestinal upset, including vomiting, soft stools, and lack of appetite.

Rarely, more serious adverse effects can occur. If there are changes in urination or yellowing of the skin (often noted on the inside of ear flaps), stop giving the medication and contact your veterinarian right away.

Cats: Meloxicam should be used with caution in cats. Cats with early undiagnosed kidney disease can suffer kidney damage with use of meloxicam, depending on the dose prescribed. Your veterinarian will carefully weigh the pros and cons of medicating your cat with meloxicam, and may order blood work and urinalysis to check your cat’s kidney function before prescribing meloxicam. Gastrointestinal upset, including vomiting, diarrhea, and lack of appetite are side effects sometimes seen in cats.

Never give meloxicam prescribed for one pet in your household to another pet without first consulting your veterinarian.

Any side effects that you observe should be reported to your veterinarian.

This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Meloxicam should not be used in patients with allergies to aspirin or other NSAIDs.

It should not be used in:

  • pets with bloody stools or vomit
  • pets that have pre-existing kidney or liver conditions
  • pets that have loss of appetite
  • pets that are taking other NSAIDs (e.g., carprofen, etodolac, firocoxib, and aspirin) or corticosteroids (e.g., prednisone and dexamethasone)
  • pets that are dehydrated
  • breeding, pregnant, lactating animals
  • puppies younger than 6 months of age, or in kittens under 4 months of age

Meloxicam should be used with caution in:

  • cats (see above)
  • pets that have ulcers or have had them in the past
  • pets that have pre-existing heart conditions
  • pets that are old, weak, or frail
  • pets that have a bleeding disorder

Are there any drug interactions I should be aware of?

Caution must be taken when meloxicam is used in conjunction with many different drugs including certain antibiotics (e. g., gentamicin, amikacin), anaesthetics, anticoagulants (e.g., heparin, warfarin), diuretics (e.g., furosemide), antifungals (e.g., fluconazole), and immunosuppressive drugs (e.g., methotrexate, cyclosporine).

It is never a good idea to mix meloxicam with corticosteroids (such as prednisone, prednisolone) or other NSAID drugs.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

Annual blood testing before and after starting the use of meloxicam is recommended to monitor liver and kidney function primarily or to detect other signs consistent with gastrointestinal ulceration. It is common for your veterinarian to recommend or require annual blood tests to assess for effects on organ function.

How do I store meloxicam?

Store meloxicam at room temperature. Do not use after the expiration date stated on the bottle.

Keep out of reach of children.

What should I do in case of emergency?

If you suspect an overdose, or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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The description of Meloxicam is a simplified author’s version of the a.com.ua website.

DO NOT SELF-MEDIATE! IT CAN BE DANGEROUS TO YOUR HEALTH!

Meloxicam: brief instructions for use

Meloxicam is a drug belonging to the group of non-steroidal anti-inflammatory drugs that have analgesic and antipyretic effects.

The composition of Meloxicam includes the main active ingredient – meloxicam. In addition, each tablet contains excipients such as lactose, starch, magnesium and povidone.

Buy Meloxicam is recommended by many experts, as the drug in question shows high anti-inflammatory activity in all models of inflammatory processes without exception.

Indications for use Meloxicam

  • Arthritis of rheumatoid type.
  • Osteoporosis, osteoarthritis.
  • Inflammation localized in the joints.
  • Other inflammatory processes accompanied by intense pain.

What are the possible contraindications to Meloxicam?

  • Hypersensitivity to meloxicam or any of the other ingredients of the medicinal product.
  • Meloxicam is not recommended for patients who have a history of pathologies such as bronchial asthma, urticaria while taking aspirin and angioedema.
  • Pregnancy, lactation and adolescence in patients under 16 years of age.
  • Abdominal bleeding that occurred while taking non-steroidal anti-inflammatory drugs.
  • Ulcerative lesions of the walls of the gastrointestinal tract.
  • Liver or kidney failure.
  • Cardiac or vascular insufficiency.

Interactions of Meloxicam with other drugs

If it is recommended to buy Meloxicam for co-administration with other non-steroidal anti-inflammatory drugs, it should be understood that such drug interactions may significantly increase the risk of bleeding.

Meloxicam significantly enhances the effect of anticoagulants, which can cause bleeding.

At the same time taking this drug with diuretics, there may be a violation of the functioning of the renal system.

Antihypertensive drugs slightly lose their effectiveness when combined with meloxicam components.

Meloxicam: method of administration and dosage

How to take Meloxicam, you can consult your doctor or read the instructions for this drug yourself. The daily dose of the drug is taken once a day during a meal, drinking plenty of water.

In order to minimize the possibility of adverse reactions, the lowest effective dosage is recommended initially. In addition, the specialist must keep the patient’s condition under control, timely conducting all the necessary studies, analyzes and examinations.

Meloxicam should be used with caution in elderly patients. This is justified by the fact that in this age group the risk of negative reactions is significantly increased. If any side effects are detected, you should immediately inform your doctor about this and stop taking the medication.

Meloxicam is not recommended for patients under 16 years of age.

In the online pharmacy apteka.com, you can check the price of Meloxicam online, as well as place an order for medicines remotely. We will help you decide on the choice of the drug, as well as send the purchase to your address.

Manual Meloxicam

Manufacturer

HELP S. A., Greece

Country of origin

Greece

Synonyms

MELOXICAM, APO-MELOXICAM, AROXICAM, ARTROZAN, ASPICAM, BI-KSIKAM, ZELOXIM, ZELOXIM FORTE, LOKSIDOL, M-KAM®, MELBEK®, MELOX, MELOXAM, MELOXAN, MELOXIC, MELOXICAM, MELOXICAM ORION, MELOKSIKAM PFAYZER ®, MELOXICAM SOPHARMA, MELOXICAM-APO, MELOXICAM-ASTRAPHARM, MELOXICAM-ZENTIVA, MELOXICAM-KV, MELOXICAM-LUGAL, MELOXICAM-MAXPHARMA, MELOXICAM-RATIOPHARM, MELOMAX, MELOMAX™, MOBIK, MOVALGIN, MOVALIS, MOVALIS®, MOVIX,MOVIKSIKAM ®, REVMALGIN, REVMOKSIKAM, REVMOKSIKAM®, RECOX, SANALIS, EXISTEN-SANOVEL

Meloxicam price in online pharmacy ampoule 1.5ml №5 PL / Berkana /

131.4 UAH Meloxicam tab. 0.0075g №20 71.8 UAH Meloxicam-KV tablets 7.5mg №20 74.6 UAH Meloxicam-LH tablets 0.0 15g №20 97 UAH Meloxicam-KV tablets 15mg №20 UAH 122.8 Meloxicam solution for injections 15mg/1. 5ml ampoule 1.5ml №5 PL/Berkana/ UAH 134.4 Meloxicam-Berkana solution for infusion 15mg/1.5 ml ampoules 1.5 ml No. 5 153 hryvnia Meloxicam-Teva solution 15mg/1.5ml №5 241.2 UAH

How long does meloxicam last? – Drugs

Disclaimer

If you have any medical questions or concerns, contact your physician. Articles in the Health Guide are based on peer-reviewed research and information from medical societies and government agencies. However, they are not a substitute for professional medical advice, diagnosis or treatment.

The time it takes for meloxicam to relieve pain depends on the dosage prescribed to you and the severity of your underlying condition. While some people may experience relief within two to three weeks of starting treatment, it may take months for the full effect to take place.

Meloxicam, a non-steroidal anti-inflammatory drug (NSAID) most commonly used to relieve pain and swelling associated with inflammatory conditions such as osteoarthritis and rheumatoid arthritis, is stronger than over-the-counter pain relievers such as Advil and Motrin.

Vitals

  • Black box warning: Meloxicam may increase the risk of heart attacks and strokes, especially in people with heart disease or other risk factors for cardiovascular disease. This risk may be higher if you take meloxicam for a long time. Meloxicam should not be used to treat pain immediately before or after heart surgery, such as after a coronary artery bypass graft (CABG) procedure. Meloxicam may also increase the risk of stomach ulcers, bleeding, and holes (perforations) in the stomach or intestines.
  • Meloxicam is an NSAID (non-steroidal anti-inflammatory drug) used to treat pain and inflammation associated with conditions such as rheumatoid arthritis and osteoarthritis.
  • Meloxicam may improve some symptoms of osteoarthritis and rheumatoid arthritis within two or three weeks.
  • Those who take higher doses of this NSAID may experience more relief during this time.
  • Meloxicam may take six months to fully show its effects.

Even one day can be a long time to suffer from arthritis pain and swelling, so quick relief is especially important when starting any new treatment. Studies show that people with rheumatoid arthritis (RA) may experience some relief as early as three weeks after starting treatment. A study that tested NSAIDs for only three weeks. found a significant improvement in patients’ morning joint pain by the end of the study (Reginster, 1996).

Patients with osteoarthritis (OA) may experience a reduction in joint pain even faster. The researchers noted evidence that meloxicam worked after just two weeks in patients receiving prescription drugs at a daily dose of 7.5 mg or 15 mg. The results were also dose-dependent; those who received higher doses of meloxicam experienced greater relief (Yocum, 2000).

But even if your symptoms do not completely disappear after a few weeks, your doctor may ask you to wait. One study showed that the effect of the drug increased during the first six months of treatment in patients with rheumatoid arthritis (Huskisson, 1996).

What is meloxicam?

Meloxicam is a prescription NSAID. approved by the US Food and Drug Administration (FDA) for the treatment of joint pain and inflammation associated with osteoarthritis (the most common form of arthritis, usually caused by wear and tear on the joints), rheumatoid arthritis (a chronic inflammatory condition), and juvenile rheumatoid arthritis (which is RA). affecting children aged two years and older) (FDA, 2012). None of these conditions can be cured, but NSAIDs such as meloxicam can manage the pain associated with joint inflammation.

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Meloxicam may also be used off-label to treat pain associated with gout flares. Gout is a painful type of arthritis characterized by sudden pain, redness, and swelling that most commonly affects one joint of the big toe, but can occur anywhere in the body. This is a result of the accumulation of uric acid in the body and exacerbations can be caused by a number of behavioral factors in susceptible individuals (Jin, 2012). Certain foods such as shellfish and red meat, and medications such as aspirin and some diuretics (water pills) increase uric acid levels in the body (ACR, 2019). While avoiding triggers is critical to preventing gout flares, meloxicam can be used to relieve gout symptoms (Gaffo, 2019).

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Meloxicam has also been used off-label. for the treatment of pain associated with ankylosing spondylitis (AS), a chronic inflammatory condition of the spine (Song, 2008). This condition is also incurable, but NSAIDs help manage joint and back pain associated with it (NIH, 2020).

Side effects of meloxicam

The most common side effects of meloxicam are diarrhea, indigestion (dyspepsia), and flu-like symptoms (FDA, 2012). Headache, dizziness, skin rashes, and other gastrointestinal problems such as heartburn, nausea, and gas are also possible. possible side effects (DailyMed, 2019).

The FDA has issued a black box warning, the most serious warning issued by this group, regarding the serious side effects of this drug on the gastrointestinal (GI) system. Meloxicam may increase the risk of bleeding, as well as the risk of stomach ulcers and perforation of the stomach or intestines. These conditions can occur without warning and can be fatal. Older adults and people with a history of gastrointestinal problems who take meloxicam are at higher risk for these side effects (FDA, 2012). Meloxicam also prevents blood clotting and slows down clotting time (Rinder, 2002; Martini, 2014). This may increase the risk of bleeding.

When to seek medical attention

You should seek medical attention immediately if you experience severe abdominal pain that does not go away, black or bloody stools (tarry stools), dizziness, or passing out.

Meloxicam may cause severe allergic reactions. Signs of an allergic reaction include hives, difficulty breathing, shortness of breath, or skin blisters. If you experience any of these symptoms, seek medical attention immediately (DailyMed, 2019).

Meloxicam strengths and brand names

Meloxicam is available as a generic drug and as Mobic or Vivlodex brand name products. Generic and brand name meloxicam tablets are available in 5mg, 7.5mg, 10mg and 15mg strengths. There are several forms of this medicine. Meloxicam is available as an oral suspension (7.5 mg/5 ml), a disintegrating tablet (7.5 mg and 15 mg dosage) and an intravenous solution (30 mg/ml), which is commonly used in a hospital setting.

Most people take one tablet per day by mouth. If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as usual. Do not double dose. Meloxicam tablets should be stored at room temperature out of the reach of children.

A 30-day supply costs between $4 to over $400, but many insurance plans cover meloxicam (GoodRx.com). The price depends on the strength and whether you buy branded or generic pills.

Meloxicam drug interactions

Combining meloxicam with other NSAIDs (such as over-the-counter NSAIDs, naproxen, acetaminophen or ibuprofen) increases the chance of developing gastrointestinal problems such as bleeding or ulcers. Meloxicam given intravenously can also cause gastrointestinal problems even if it is not taken by mouth.

Some medicines can put you at an increased risk of bleeding if taken with meloxicam because this prescription medicine affects the function of platelets, the component in our blood that stops bleeding. For this reason, blood thinners (eg, warfarin), antiplatelet agents (eg, aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs) should not be taken with meloxicam (DailyMed, 2019).). Drinking alcohol while taking meloxicam also increases the risk of bleeding (FDA, 2012).

Medicines for high blood pressure may not work when taken with meloxicam. Medicines that lower blood pressure (antihypertensives) such as ACE inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers may be less effective when taken with meloxicam (Fournier, 2012; Johnson, 1994).

Meloxicam warnings

The FDA has issued a black box warning for meloxicam, which is a warning about serious or life-threatening complications that may result from taking this medication. Black box warning: Meloxicam may increase the risk of heart attacks and strokes, especially in people with heart disease or other cardiovascular risk factors. This risk may be higher if you take meloxicam for a long time.

Meloxicam should not be used to treat pain immediately before or after heart surgery, such as coronary bypass surgery (CABG), as an NSAID. increase the risk of heart attack or stroke by following these procedures (Kulik, 2015). Meloxicam may also increase the risk of bleeding, ulcers, and holes (perforations) in the stomach or intestines (FDA, 2012).

NSAIDs such as meloxicam should also not be taken during the third trimester of pregnancy. These drugs can affect the development of the fetal heart and redirect blood flow in the fetal body, which can lead to progressive heart problems later (Bloor, 2013; Enzensberger, 2012).

Recommendations

  1. American College of Rheumatology (ACR) (2019). Gout. Retrieved September 16, 2020 from https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Gout
  2. Bermas, B. L. (2014). Non-steroidal anti-inflammatory drugs, glucocorticoids, and disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis before and during pregnancy. Current Opinion in Rheumatology, 26(3), 334-340. DOI: 10.1097 / bor.0000000000000054. Extracted from https://pubmed.ncbi.nlm.nih.gov/24663106/
  3. Bloor, M. & Paech, M. (2013). Non-steroidal anti-inflammatory drugs during pregnancy and early lactation. Anesthesia and Pain Relief, 116(5), 1063-1075. DOI: 10.1213 / ane.0b013e31828a4b54. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23558845/
  4. DailyMed (2019). Meloxicam tablet. Retrieved September 16, 2020 from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5e12448-1ca1-46a4-8de4-e8b94567e5a8
  5. Enzensberger C, Winhard J, Weichert J, Kavetsky A., Degenhardt J., Vogel M. & Axt-Flidner R. (2012). Idiopathic narrowing of the fetal ductus arteriosus. Journal of Ultrasound in Medicine, 31(8), 1285-1291. DOI: 10.7863 / jum.2012.31.8.1285. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22837295/
  6. Food and Drug Administration (FDA) (2012). Mobik (meloxicam) tablets and oral suspension. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/012151s072lbl.pdf
  7. Fournier, J.P., Sommet, A., Burrel, R., Oustrick, S., Patak, A ., Lapeyre-Mestre, M., & Montastruc, J. L. (2012). Non-steroidal anti-inflammatory drugs (NSAIDs) and intensified treatment of hypertension: a population-based cohort study. European Journal of Clinical Pharmacology, 68(11), 1533–1540. DOI: 10.1007 / s00228-012-1283-9. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22527348/
  8. Gaffo, A.L., MD, MsPH. (2019, December 4). Treatment of attacks of gout. Retrieved September 18, 2020, from https://www.uptodate.com/contents/treatment-of-gout-flares/
  9. GoodRx.com (undated). Meloxicam. Retrieved September 16, 2020 from https://www.goodrx.com/meloxicam
  10. Huskisson, E.C., Ghozlan, R., Kurthen, R., Degner, F. L., & Bluhmki, E. (1996). A long-term study to evaluate the safety and efficacy of meloxicam therapy in patients with rheumatoid arthritis. Rheumatology, 35 (Appendix 1), 29-34. DOI: 10.1093 / rheumatology / 35.suppl_1.29. Retrieved from https://academic.oup.com/rheumatology/article/35/suppl_1/29/1782379
  11. Jin, M., Yang, F., Yang, Y., Yin, Y., Lo, J. J ., Wang, H., & Yang, X. F. (2012). Uric acid, hyperuricemia and vascular disease. Frontiers in the Biological Sciences (Landmark ed. ), 17, 656–669. DOI: 10.2741/3950. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247913/
  12. Johnson A.G., Nguyen T.V. and Day R.O. (1994). Do non-steroidal anti-inflammatory drugs affect blood pressure? Meta-analysis. Annals of Internal Medicine, 121(4), 289-300. DOI: 10.7326 / 0003-4819-121-4-199408150-00011. Retrieved from https://pubmed.ncbi.nlm.nih.gov/8037411/
  13. Martini, A.K., Rodriguez, K.M., Cap, A.P., Martini, V.Z., and Dubik , M. A. (2014). Acetaminophen and meloxicam inhibit platelet aggregation and coagulation in human blood samples. Blood Coagulation and Fibrinolysis, 25(8), 831-837. DOI: 10.1097/mbc.0000000000000162. Retrieved from https://pubmed.ncbi.nlm.nih.gov/25004022/
  14. National Institutes of Health (NIH). (2014, November 01). Symptoms and causes of peptic ulcer (stomach ulcer). Retrieved September 24, 2020, from https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers/symptoms-causes
  15. National Institutes of Health (NIH). (2020, August 17). Ankylosing Spondylitis – Home Genetics Guide – NIH. Retrieved September 22, 2020, from https://ghr.nlm.nih.gov/condition/ankylosing-spondylitis
  16. Reginster, J. Y., Distel, M., & Bloomkey, E. (1996). A double-blind, 3-week study comparing the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis. Rheumatology, 35 (Appendix 1), 17-21. DOI: 10.1093 / rheumatology / 35.suppl_1.17. Extracted from https://www.researchgate.net/profile/Erich_Bluhmki/publication/14569192_A_Double-Blind_Three-Week_Study_to_Compare_the_Efficacy_and_Safety_of_Meloxicam_75_mg_and_Meloxicam_15_mg_in_Patients_with_Rheumatoid_Arthr itis/links/599d516745851574f4b258e4/A-Double-Blind-Three-Week-Study-to-Compare-the-Efficacy-and- Safety- of-Meloxicam-75-mg-and-Meloxicam-15-mg-in-Patients-with-Rheumatoid-Arthritis.pdf
  17. Rinder, H.M., Tracey, J.B., Suhrada, M., Wang, K., Gagne, R. P., & Wood, K. S. (2002). Effect of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled study.