What are the primary uses of Larpose 2 MG Tablet. How does lorazepam work in the body. What are the most common side effects of Larpose. Is Larpose safe during pregnancy and breastfeeding. How does Larpose interact with other medications.

Understanding Larpose 2 MG Tablet: Composition and Mechanism of Action

Larpose 2 MG Tablet is a pharmaceutical product containing lorazepam, a potent benzodiazepine medication. Manufactured by CIPLA LIMITED, this tablet is designed to address various neurological and psychological conditions. But how exactly does it work?

Lorazepam, the active ingredient in Larpose, operates by influencing the central nervous system. It targets specific neurotransmitters in the brain, particularly gamma-aminobutyric acid (GABA). By enhancing GABA’s inhibitory effects, lorazepam promotes a calming effect throughout the nervous system.

This mechanism of action is responsible for the sedative, anxiolytic, and anticonvulsant properties of Larpose. The tablet’s effects are typically felt within 20-30 minutes of oral administration, with peak concentrations reached after about 2 hours.

Key Therapeutic Applications of Larpose 2 MG Tablet

Larpose 2 MG Tablet has a wide range of clinical applications, making it a versatile tool in the medical field. Its primary uses include:

• Treatment of insomnia
• Management of anxiety disorders
• Control of status epilepticus
• Alleviation of panic attacks and disorders
• Pre-operative sedation
• Relief of premenstrual syndrome symptoms
• Treatment of specific phobias
• Management of alcohol withdrawal syndrome

In the context of insomnia, how does Larpose promote sleep? The medication enhances GABA activity, which helps to slow down brain activity and induce a state of relaxation conducive to sleep. For anxiety disorders, Larpose works by dampening the excessive neuronal activity associated with anxiety, providing a sense of calm and reducing symptoms like restlessness and worry.

Potential Side Effects and Safety Considerations

While Larpose 2 MG Tablet can be highly effective, it’s crucial to be aware of potential side effects. Common adverse reactions include:

• Sedation and drowsiness
• Headaches and dizziness
• Difficulty concentrating
• Memory impairment
• Constipation
• Blurred vision
• Nausea and vomiting
• Low blood pressure

Are these side effects a cause for immediate concern? While most side effects are mild and transient, it’s important to consult a healthcare provider if they persist or worsen. Severe side effects, though rare, may include respiratory depression, particularly when Larpose is combined with other central nervous system depressants.

Contraindications and Precautions for Larpose Use

Certain conditions and factors may contraindicate the use of Larpose 2 MG Tablet. These include:

• Known allergy to lorazepam or other benzodiazepines
• Severe liver problems
• Respiratory depression
• Acute narrow-angle glaucoma
• Concurrent use of opioids
• Chronic alcoholism
• Sleep apnea
• Myasthenia gravis
• History of drug dependence or abuse

Why is Larpose contraindicated in patients with respiratory depression? Benzodiazepines like lorazepam can further depress respiratory function, potentially leading to dangerous breathing difficulties in susceptible individuals.

Special Populations: Pregnancy and Breastfeeding

Can Larpose be used during pregnancy? The use of Larpose during pregnancy is generally not recommended due to potential risks to the fetus. It’s classified as a category D medication, indicating evidence of fetal risk. Similarly, Larpose is not advised during breastfeeding as lorazepam can be excreted in breast milk, potentially affecting the infant.

Dosage Guidelines and Administration

The appropriate dosage of Larpose 2 MG Tablet varies depending on the condition being treated and individual patient factors. Generally, the tablet is taken orally, with or without food. It can also be administered sublingually for faster absorption in some cases.

How should Larpose be taken for optimal effect? It’s crucial to follow the prescribed dosage and timing instructions provided by your healthcare provider. The tablet should be swallowed whole, not crushed or chewed. For sublingual administration, place the tablet under the tongue and allow it to dissolve.

Dosage Adjustments

Dosage adjustments may be necessary for certain populations, such as elderly patients or those with liver or kidney impairment. In these cases, lower doses are typically recommended to minimize the risk of adverse effects.

Drug Interactions and Precautions

Larpose 2 MG Tablet can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. Significant interactions may occur with:

• Opioid medications (e.g., fentanyl, morphine)
• Other central nervous system depressants
• Certain antidepressants
• Antipsychotic medications
• Anticonvulsants
• Certain antifungal drugs

Why are interactions with opioids particularly concerning? The combination of Larpose with opioids can lead to profound sedation, respiratory depression, coma, and even death. This interaction underscores the importance of informing your healthcare provider about all medications you’re taking.

Alcohol and Larpose

Is it safe to consume alcohol while taking Larpose? Alcohol consumption should be strictly avoided when using Larpose. The combination can dramatically increase sedation and impair cognitive and motor functions, potentially leading to dangerous situations.

Long-term Use and Dependence Potential

While Larpose can be highly effective for short-term use, long-term administration requires careful consideration due to the potential for dependence and tolerance. Prolonged use may lead to physical and psychological dependence, making it difficult to discontinue the medication.

How can the risk of dependence be minimized? Healthcare providers typically prescribe Larpose for short durations and at the lowest effective dose. When discontinuation is necessary, a gradual tapering of the dose under medical supervision is recommended to minimize withdrawal symptoms.

Withdrawal Symptoms

Abrupt discontinuation of Larpose, especially after prolonged use, can lead to withdrawal symptoms such as:

• Increased anxiety and restlessness
• Insomnia
• Irritability
• Tremors
• Sweating
• Nausea and vomiting
• In severe cases, seizures

Monitoring and Follow-up

Regular monitoring is crucial for patients taking Larpose 2 MG Tablet, especially during the initial treatment period and any dose adjustments. This may include:

• Assessment of therapeutic response
• Evaluation of side effects
• Monitoring for signs of dependence or misuse
• Periodic liver and kidney function tests
• Assessment of cognitive function, particularly in elderly patients

How often should follow-up appointments be scheduled? The frequency of follow-up appointments can vary based on individual patient needs, but typically, more frequent visits are recommended during the initial treatment phase, with less frequent follow-ups once the patient is stable on the medication.

Patient Education

Effective patient education is crucial for the safe and appropriate use of Larpose. Key points to emphasize include:

• The importance of adhering to the prescribed dosage
• Potential side effects and when to seek medical attention
• The risks associated with alcohol consumption and operating machinery
• The need to inform healthcare providers about all medications being taken
• The importance of not abruptly discontinuing the medication

Alternative Treatments and Complementary Approaches

While Larpose can be highly effective, it’s not the only option for managing conditions like anxiety and insomnia. Alternative treatments may include:

• Other classes of anxiety medications (e.g., SSRIs, SNRIs)
• Cognitive-behavioral therapy (CBT)
• Relaxation techniques and mindfulness practices
• Lifestyle modifications (e.g., sleep hygiene improvements, stress reduction strategies)
• Natural supplements (under medical supervision)

Can these alternatives be as effective as Larpose? The efficacy of alternative treatments can vary depending on the individual and the specific condition being treated. In many cases, a combination of pharmacological and non-pharmacological approaches may provide the best outcomes.

Integrative Approach

An integrative approach to treatment, combining medication like Larpose with complementary therapies, may offer comprehensive management of anxiety, insomnia, and related conditions. This approach can potentially reduce the required medication dose and minimize the risk of dependence.

How can patients incorporate complementary approaches alongside Larpose treatment? It’s essential to discuss any complementary therapies with your healthcare provider to ensure they are safe and appropriate in conjunction with Larpose. Some techniques, such as deep breathing exercises or progressive muscle relaxation, can be safely practiced at home to enhance the overall treatment effect.

Larpose in Special Clinical Scenarios

Larpose 2 MG Tablet may be used in various specialized clinical situations, each requiring careful consideration:

Perioperative Use

Larpose is often employed in perioperative settings for its anxiolytic and amnestic properties. How does it benefit surgical patients? By reducing preoperative anxiety, Larpose can contribute to smoother anesthetic induction and potentially improve postoperative outcomes. However, careful dosing is crucial to avoid excessive sedation or respiratory depression.

Status Epilepticus

In cases of status epilepticus, a life-threatening condition characterized by prolonged seizures, Larpose may be administered intravenously. Why is rapid action crucial in this scenario? Quick control of seizure activity is essential to prevent neurological damage and other complications associated with prolonged seizures.

Alcohol Withdrawal Syndrome

Larpose can play a vital role in managing alcohol withdrawal syndrome, helping to prevent and treat symptoms such as anxiety, tremors, and seizures. How does it compare to other benzodiazepines in this context? While several benzodiazepines are used for alcohol withdrawal, Larpose’s intermediate duration of action can provide a good balance between symptom control and flexibility in dosing.

Future Directions and Research

As our understanding of neuropsychiatric disorders and pharmacology evolves, research continues to explore new applications and refinements for medications like Larpose:

Novel Formulations

Researchers are investigating alternative delivery methods for lorazepam, such as intranasal sprays or long-acting formulations. How might these innovations benefit patients? Novel formulations could potentially offer faster onset of action, improved bioavailability, or reduced frequency of dosing, enhancing both efficacy and patient compliance.

Personalized Medicine Approaches

Advancements in pharmacogenomics may lead to more personalized prescribing of benzodiazepines like Larpose. What potential benefits does this approach offer? By considering individual genetic factors that influence drug metabolism and response, healthcare providers may be able to optimize dosing and minimize adverse effects on a patient-specific basis.

Combination Therapies

Research is ongoing into the potential benefits and risks of combining Larpose with other medications or therapeutic approaches. Could strategic combinations enhance efficacy while mitigating risks? Some studies are exploring whether combining lower doses of benzodiazepines with other anxiolytic or sleep-promoting agents might provide effective treatment with reduced risk of dependence.

As research in these areas progresses, it’s likely that our approach to using medications like Larpose will continue to evolve, potentially offering more tailored and effective treatment options for patients with anxiety, insomnia, and related conditions.

Larpose 2 MG Tablet (10): Uses, Side Effects, Price & Dosage

HomeLarpose 2mg Tablet

By CIPLA LIMITED

10 Tablet(s) in Strip

All the Products are packed and stored Safely

Larpose 2 MG Description

Larpose Tablet contains an active ingredient called lorazepam which belongs to a class of medications known as benzodiazepines. This medicine acts on the brain and nerves (central nervous system). It

is an intermediate-acting tranquilliser that interferes with the natural state of certain neurotransmitters called gamma-aminobutyric (GABA). Lorazepam binds to these GABA receptors and enhances the GABA enhanced synaptic inhibition, responsible for its calmness and sedation effects.

Product Summary

Check more medicines with composition as Lorazepam(2. 0 Mg)

Uses of Larpose 2 MG

• Insomnia

• Anxiety disorders

• Status epilepticus

• Panic attacks and disorders

• Before surgery

• Premenstrual syndrome

• Phobias

• Alcohol Withdrawal Syndrome

Contraindications of Larpose 2 MG

If you are allergic to lorazepam
If you have liver problems
If you have respiratory depression
If you have glaucoma (optic nerve damage)
If you are using it with opioids
If you are a chronic alcoholic
If you have sleep apnoea
If you have chronic respiratory illness
If you have myasthenia gravis (neuromuscular disease)
If you have medicine dependency or medicine abuse
If you have kidney disease
If you have Chronic Obstructive Pulmonary Disease (COPD)…

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Side effects of Larpose 2 MG

• Sedation

• Drowsiness

• Headaches

• Dizziness

• Lightheadedness

• Irritability

• Difficulty concentration

• Memory loss

• Impaired judgement

• Constipation

• Depression

• Blurred vision

• Talkativeness

• Nausea

• Vomiting

• Low blood pressure

• Increased salivation

• Nasal congestion

Precautions and Warnings of Larpose 2 MG

Pregnancy

Q:

Can I take Larpose Tablet during pregnancy?

A:

No, avoid taking Larpose Tablet during pregnancy since it is a category D medicine. There are certain teratogenic or foetus-harming substances in the medicine. Therefore the use of this medicine during pregnancy is not recommended. If a benzodiazepine is required, a medicine other than Larpose can be preferred. Consult a doctor or a gynaecologist before starting any benzodiazepine during pregnancy. Never self prescribe, or self medicate.

Breast Feeding

Q:

Can I take Larpose Tablet while breastfeeding?

A:

No, Larpose Tablet is not recommended during breastfeeding as lorazepam is secreted in breast milk. It may cause withdrawal symptoms in the baby. If a benzodiazepine is required, a medicine other than Larpose can be preferred. Consult a doctor or a gynaecologist before starting any benzodiazepine during pregnancy. Never self prescribe, or self medicate.

Driving

Q:

Can I drive if I have taken Larpose Tablet?

A:

Avoid driving if you have taken tablet Larpose Tablet as it will cause sedation, drowsiness, dizziness, impaired judgement, and fainting.

Alcohol

Q:

Can I consume alcohol with Larpose Tablet?

A:

No, avoid consuming alcohol while taking Larpose Tablet as it will cause sedation, drowsiness, respiratory depression, slow and shallow breathing. Serious drinking of alcohol while taking Larpose Tablet may result in a coma.

Other General Warnings

Talk to your doctor if

• You are allergic to lorazepam.

• You have liver disease.

• You have kidney disease.

• You have a history of medicine abuse or dependence.

• You are a chronic alcoholic.

• You have sleep apnea.

• You have lung issues like Chronic Obstructive Pulmonary Disease (COPD).

• You have depression.

• You have narrow-angle glaucoma.

Mode of Action of Larpose 2 MG

How Does It Work?

Lorazepam is a benzodiazepine that binds itself to a Gamma-aminobutyric (GABA) receptor present in the postsynaptic neuron and enhances its inhibitory action. The increased neuronal excitability to chloride ions results in hyperpolarisation of the neuronal membrane and results in stabilisation….

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Directions for Use of Larpose 2 MG

• Take medicine as directed by your physician.

• You can take Larpose Tablet with or without food.

• Take the tablet orally and swallow it whole.

• Do not crush, chew, or break the pill.

• Do not share your medicine with anyone.

• You can also take the tablet sublingually by keeping it below your tongue for faster disintegration.

Interactions of Larpose 2 MG

Interactions with other medicines

• Opioids like fentanyl, morphine, codeine

• CYP3A4 Inhibitors like Ketoconazole, Clarithromycin, Itraconazole, Erythromycin, Ritonavir, Verapamil, Diltiazem

• SSRIs like sertraline, fluoxetine, etc.

• TCA like imipramine

• Antipsychotics like risperidone, clozapine

• Antihistamines and muscle relaxants

Interactions with food items

Storage and disposal of Larpose 2 MG

Store Larpose in a dry, cool place away from heat and humidity. Keep the tablets in the same packing as they came. Keep them out of reach of children and pets. The pills that are not needed anymore should be safely disposed of to avoid accidental usage. They should not be flushed in the toilet….

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Dosage of Larpose 2 MG

Overdose

• Overdose of Larpose Tablet can result in drowsiness, respiratory depression, slowed breathing, sedation, anxiety, depression, panic attacks, insomnia, headache, sweating, delirium, slurred speech, coma, muscle fatigue, ataxia, feeling lightheaded, fainting, and shallow breath. Consult your physician in case of an overdose or rush to emergency medical services….

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Missed a Dose

If one misses a dose, one should take the missed dose as soon as one remembers. If it’s time for the next dose, one should continue with the regular dosage. Do not take a double dose to compensate for the missed dose….

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Frequently Asked Questions (FAQs)

Q: How much time does it take for Larpose Tablet to start showing its effect?

A: It takes around 30 mins to 1 hour for Larpose Tablet or lorazepam to show its effect clinically when taken orally. The onset of action is even faster if lorazepam is taken through the intravenous or intramuscular route. It has a total duration of action of around 11-20 hours.

Q: Can I take Larpose Tablet if I have kidney disease?

• Lorazepam: Worsening of delirium: 3 case reports. React Wkly [Internet]. 2017 [cited 2022 Jan 24];1633(1):468–468.
• Lorazepam (ativan). Med Lett Drugs Ther [Internet]. 1978 [cited 2022 Jan 24];20(6):31–2.
• Lorazepam 2.5mg Tablets [Internet]. Org.uk. [cited 2022 Jan 24].

Product Details

Brand

LARPOSE

Expires on or After

02/10/2023

• LARPOSE 1MG TABLET

Last Updated on: 02 Feb 2022 | 10:57 AM (IST)

Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner’s medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.

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Larpose 2mg Tablet: View Uses, Side Effects, Price and Substitutes

Product introduction

Larpose 2mg Tablet is a prescription medicine used to treat symptoms of short term anxiety and anxiety disorders. It helps to decrease the abnormal and excessive activity of the nerve cells and calms the brain.

Larpose 2mg Tablet is taken by mouth with or without food. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may increase seizure frequency.

Some common side effects of this medicine include fatigue and balance disorder. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Uses of Larpose Tablet

• Treatment of Short term anxiety
• Treatment of Anxiety disorder

Benefits of Larpose Tablet

In Treatment of Short term anxiety

Larpose 2mg Tablet reduces the symptoms of excessive anxiety and worry that may arise in stressful conditions such as an exam or job interview. It can also reduce feelings of restlessness, tiredness, difficulty concentrating and feeling irritable. This will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.

In Treatment of Anxiety disorder

Larpose 2mg Tablet helps relieve symptoms of many anxiety disorders including obsessive-compulsive disorder and generalised anxiety disorder by increasing the level of a chemical called GABA in your brain. This prevents abnormal symptoms of anxiety such as restlessness, tiredness, difficulty concentrating, feeling irritable and sleep problems. It helps you feel calm with a better ability to deal with problems. Exercise and a healthy diet can also improve your mood. Keep taking the medicine until your doctor advises you to stop.

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Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Larpose

• Dizziness
• Sedation
• Injection site pain
• Fatigue
• Muscle weakness
• Drowsiness

How to use Larpose Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Larpose 2mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Larpose Tablet works

Larpose 2mg Tablet is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Larpose 2mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Larpose 2mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Larpose 2mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Larpose 2mg Tablet should be used for short periods and sleepiness of the baby should be watched. The withdrawal of Larpose 2mg Tablet should be gradual.

Driving

UNSAFE

Larpose 2mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Larpose 2mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Larpose 2mg Tablet may be needed. Please consult your doctor.
However, inform your doctor if you have any underlying kidney disease.

Liver

CAUTION

Larpose 2mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Larpose 2mg Tablet may be needed. Please consult your doctor.
Use of Larpose 2mg Tablet is not recommended in patients with severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

• The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
• It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
• Avoid consuming alcohol as it may increase dizziness and drowsiness.

• Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

• Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Fact Box

Chemical Class

Benzodiazepines Derivative

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Benzodiazepines

Interaction with drugs

Taking Larpose with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Abacavir

Brand(s): Abamune, A-Bec, Virol

Serious

Adefovir

Brand(s): Adesera, Adheb, Adfovir

Serious

Amisulpride

Brand(s): Stozen, Sulpigold, Amisulide

Serious

Amitriptyline

Brand(s): Triptam

Serious

View all interactions

Patient concerns

I feel short term memory loss , anxiety and mood disorder

Dr. Vikas Sharma

Neurology

Do Mri brain and thyroid testing

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I feel fear, anxiety, fast heart beat, ear tinitus Drowsy mind, No activeness, At present im taking liofen xl 20mg, and larpose 2mg, daily night

Dr. Jyoti Kapoor Madan

Psychiatry

Based in your clinical history, your doctor plans the type of medicine and it’s dose and duration. For first episode of anxiety/ depression/ panic, the usual maintenance phase is 6 months of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. To take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist is important. For second opinion, seek a proper consultation with another psychiatrist and take along your previous prescriptions.

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My mother she is taking tablets larpose 2mg & trinicalm plus since 20yrs. Both tablet were suggested by doctor at that time now the same tablets are very difficult to get in medical & also substitutes not available. Since that she is suffering from sleeping disorder.

Dr. Jyoti Kapoor Madan

Psychiatry

Sleeping pills are not recommended for more than few weeks, and if they are needed, regular follow up with psychiatrist are recommended. The psychiatrist will need to evaluate the reason for sleep issues and treat accordingly.

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i am suffering from anxiety disorder and i am on anxiety medications does ayurveda has any treatment for anxiety disorder

Dr. Aanchal Maheshwari

Ayurveda

Yes, Panchkarma is the best you should take sitting of sirodhara

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Mixed anxiety depressive disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one’s inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

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Generalized anxiety disorder problem

Dr. Jyoti Kapoor Madan

Psychiatry

Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it’s an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it’s better to see a psychiatrist.

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Mental Depression , Anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one’s inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

MORE

User feedback

Patients taking Larpose 2mg Tablet

Once A Day

83%

Twice A Day

8%

Thrice A week

4%

Thrice A Day

3%

Alternate Day

2%

Four Times A *

1%

*Four Times A Day

What are you using Larpose Tablet for?

Short term an*

73%

Others

18%

Anxiety disor*

9%

*Short term anxiety, Anxiety disorder

How much was the improvement?

Average

44%

Excellent

39%

Poor

17%

What were the side-effects while using Larpose 2mg Tablet?

No Side Effec*

50%

Nail disorder

17%

Balance disor*

17%

Dizziness

17%

*No Side Effect, Balance disorder (loss of balance)

How do you take Larpose Tablet?

With food

67%

With or witho*

33%

*With or without food

Please rate Larpose 2mg Tablet on price

Average

56%

Expensive

22%

Not Expensive

22%

FAQs

Q.

Is Larpose 2mg Tablet an opioid? Is it a habit-forming medicine?

No, Larpose 2mg Tablet is not an opioid. It belongs to the benzodiazepine group of medicines and is used for short-term treatment (2-4 weeks) only. It is a habit-forming medicine and can make a person physically and psychologically dependent.

Q. Can Larpose 2mg Tablet be used as a sleeping pill?

Larpose 2mg Tablet is used for sleeping difficulties caused due to short-term anxiety. One of the very common side effects of Larpose 2mg Tablet is drowsiness and sleepiness. It calms the mind, and therefore, helps a person to sleep.

Q. For how long will Larpose 2mg Tablet stay in my system?

Larpose 2mg Tablet may take around 3 days to get completely removed from the system.

Q. Are there any symptoms that I would experience if I get addicted to Larpose 2mg Tablet?

The most important symptom of addiction is that you may feel unpleasant if you do not take Larpose 2mg Tablet. Another symptom could be that you may increase the dose on your own to feel its effect.

Q. If I suddenly stop taking Larpose 2mg Tablet, will it affect me adversely?

You should reduce the dose of Larpose 2mg Tablet gradually before completely stopping it. Suddenly stopping it may lead to withdrawal symptoms which include loss of the sense of reality, feeling detached from life, and unable to feel emotion. Some patients have also experienced numbness or tingling in the arms or legs, tinnitus (ringing sounds in the ears), uncontrolled or overactive movements, twitching, shaking, feeling sick, being sick, stomach upsets or stomach pain, loss of appetite, agitation and abnormally fast heart beats. It can also cause panic attacks, dizziness or feeling faint, memory loss, hallucinations, feeling stiff and unable to move easily, feeling very warm, convulsions (sudden uncontrolled shaking or jerking of the body) and oversensitivity to light, sound and touch.

Q. Does Larpose 2mg Tablet cause weight gain?

The effect of Larpose 2mg Tablet on weight gain or loss is not known.

Q. Does Larpose 2mg Tablet cause depression?

If you have a history of depression then it may increase the risk of developing depression again. Larpose 2mg Tablet should not be used alone in depressed patients because it may cause suicidal tendencies in such patients.

Q. My old uncle is taking Larpose 2mg Tablet for sleeplessness associated with anxiety. Can it affect his memory?

Though it is rare, but use of Larpose 2mg Tablet can cause memory impairment, which may be more apparent in old age patients.

Q. Are there any harmful effects of taking more than the recommended doses of Larpose 2mg Tablet?

Taking more than the recommended dose of Larpose 2mg Tablet may cause loss of muscle control, low blood pressure, mental confusion, slow breathing and even coma. If you have taken higher than the recommended dose of Larpose 2mg Tablet, seek immediate medical help immediately.

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Disclaimer:

Tata 1mg’s sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

1. Stahl SM, editor. Lorazepam. In: Stahl’s Essential Pschopharmacology: Prescriber’s Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 367-71.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 819-20.

3. Drugs.com. Lorazepam Pregnancy and Breastfeeding Warnings. [Accessed 25 Mar. 2019] (online) Available from:

4. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 20 Mar. 2019] (online) Available from:

5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:

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Name: Cipla Ltd

Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: India

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What to do if you suspect that you are having side effects from a vaccine? – vaktsineeri.ee

Maija Uusküla , Head of the Safety Supervision Bureau of the Medicines Board

The vast majority of those vaccinated do not experience any particular side effects after being vaccinated against COVID-19. But if you suspect you have some more serious side effects, you should definitely contact your family doctor.

Reports of side effects in Estonia are collected by the State Medicines Board. The collected information on side effects received by the Medicines Board is published on a weekly basis on the website of the agency www.ravimiamet.ee

Most often, after vaccination, one has to deal with a post-vaccination reaction that lasts a couple of days, for example, soreness or sensitivity at the injection site, flu-like symptoms such as dizziness, headache, slight fever, drowsiness, and the like.

These reactions can be relieved with pain medication or a cold compress if necessary. In most cases, these symptoms resolve within a couple of days. However, if the discomfort persists for longer, or if you feel really bad after the vaccination, contact your family doctor. All post-vaccination complaints must be reported to the family doctor. To further describe the safety profile of COVID-19 vaccines, all healthcare professionals should report all systemic and serious (including local) adverse events that may be associated with the vaccine. If the doctor reports this to the Department of Medicines, then the person who received the vaccine does not need to do this separately.

You can also report on the website of the Department of Medicines those reactions that, according to the doctor, are not related to the vaccine. The Department collects information in Estonia related to the use of vaccines (and other medicines) and the occurrence of side effects in order to identify new side effects or to clarify changes in the severity and frequency of already known side effects. And also whether a new message can better minimize the risks.

Information sent requires control

The Department of Medicines analyzes the data received in the report and makes an initial assessment of whether these health problems are related to a particular drug or vaccine, or if the problems were caused by other causes. If reports are received containing information about serious reactions, the Department of Medicines always asks the patient for the contact details of the doctor in order to obtain medical confirmation and additional data, for example, whether the patient has comorbidities or other risk factors, what tests and studies were performed.

The data collected in Estonia are transferred to the side effects database of the European Medicines Agency. The safety assessment of vaccines is carried out by the Risk Assessment Committee of the European Medicines Agency and the Committee for Medicinal Products for Human Use, which also includes experts from the Estonian Medicines Board. Experts regularly evaluate all new possible side effects by analyzing large amounts of data, taking into account the frequency of manifestation of the disease / health disorder in the general population. Similarities found in the general population and more frequent than previously thought reactions identified during the analysis lead to the assertion of an association between the vaccine and the reaction to it.

The Estonian and European side effects database (adrreports.eu) cannot be used to decide on the safety of any vaccine or medicinal product, because it contains all the reports that are received about drugs and vaccines, and only after that they are evaluated and control.

The Centers for Disease Control and Prevention (CDC) Vaccine Adverse Event Reporting System (VAERS) database is compiled in the same way. Reports enter the database without control and there are reports of cases where there is no connection between the vaccine, the drug and the reaction.

A lot of people are being vaccinated against the coronavirus infection in a very short time. This means a noticeably greater than usual probability that the manifestation of a particular disease or its aggravation occurs at the time of vaccination, but is not a consequence of it.

Knowledge is growing

When assessing safety, it is important to take into account the frequency of manifestation of certain diseases in the general population. If, when evaluating data from all over Europe, it turns out that the vaccinated as a whole get a certain disease more often, or, for example, it manifests itself in a certain age group more often than in the general population, then this is a very significant danger signal. If the danger signal is confirmed, it is subjected to a separate assessment, and if a clear justification for the relationship is determined, then this is included in the instructions for use of the drug as a side effect.

Thus, myocarditis was added as a possible side effect to mNRK vaccines (Pfizer/Corminatry and Moderna/Spikevax), and thrombosis syndrome with thrombocytopenia was added to adenoviral vaccines (Janssen, AstraZeneca/Vaxzevria) as a possible side effect. All side effects that are now associated with vaccines are listed in the instructions for use.

Evaluation of COVID-19 vaccine safety data so far shows that all four COVID-19 vaccines used in Estoniaserious side effects are very rare, can be avoided with precautions, and can be quickly diagnosed and treated. For timely diagnosis and treatment, the patient must necessarily report all his complaints to his doctor.

Warnings on what to be aware of are in the package leaflet. If you have any questions, you can contact your family doctor or call the family doctor consultation telephone number 1220.

What are the side effects of the Johnson & Johnson vaccine? – Kommersant FM

• Radio “Kommersant FM”

Cases of rare illness reported in US following Johnson & Johnson vaccination. But doctors say the effects of COVID-19 are more serious than the side effects of the vaccine. This is the Guillain-Barré syndrome. Because of this disease, the immune system attacks the nerve cells. According to the American regulator, there were only about 100 cases of the syndrome for 13 million injections. However, a side effect warning will be added to the drug label. Details are in the review of the foreign press on Kommersant FM.

Photo: Lucas Landau, Reuters

Photo: Lucas Landau, Reuters

According to The Wall Street Journal , Guillain-Barré syndrome can appear after an injection with adenovirus vaccines. These, in addition to Johnson & Johnson, include the drug from AstraZeneca. For vaccines based on modified RNA (these are Pfizer and Moderna), such effects are not typical. According to the American regulator, the syndrome appeared two weeks after vaccination – mainly in men over 50 years old.

Guillain-Barré syndrome is a very rare autoimmune disorder that can cause muscle weakness, tingling in the arms and legs, difficulty walking and speaking, and paralysis. As The New York Times clarifies, most symptoms resolve within a few weeks, but in some cases the nerve damage may be permanent. Every year in the United States, the syndrome is detected in 3-6 thousand patients. Why the disease occurs is unknown. But often Guillain-Barré syndrome appears against the background of infections, such as influenza. There are also cases of illness after suffering COVID-19.

CNN clarifies that the injection rarely causes illness. Only 100 cases out of 13 million vaccinations are known. At the same time, 95 people were hospitalized, one died. US health authorities recommend not delaying vaccination. According to experts, during a large-scale vaccination campaign, rare side effects are always observed. The benefits of the vaccine outweigh the potential harm.

Although the syndrome is rare, this news could hit Johnson & Johnson and US plans to vaccinate as many people as possible, writes The Washington Post . There are high expectations for Janssen because it is one-component and can be easily transported due to the relatively high storage temperature. That is, the vaccine is especially useful for use in poor and hard-to-reach areas.

But information about new side effects may increase skepticism among those who have not yet been vaccinated, especially given Johnson & Johnson’s past problems. In April, the regulator forbade the use of the drug for several days due to the risk of thrombosis, as a result, fears were considered exaggerated. In the spring, one of the factories where the vaccine is produced was also closed.