Lovenox Interactions: Uses, Dosage, Side Effects, Interactions, Warning

12.03.202214.07.2023 by alexxlab

What are the uses of Lovenox? What is the recommended dosage of Lovenox? What are the side effects of taking Lovenox? How does Lovenox interact with other drugs and diseases? What should you be aware of when taking Lovenox?

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Lovenox: Understanding the Medication

Lovenox, the brand name for the generic drug enoxaparin, is an anticoagulant medication used to prevent and treat various blood clotting disorders. It belongs to the class of drugs known as low-molecular-weight heparins (LMWHs). Lovenox is commonly prescribed to patients at risk of developing blood clots, such as those undergoing certain surgical procedures or those with certain medical conditions.

Uses of Lovenox

Lovenox has several approved uses, including:

Prevention of deep vein thrombosis (DVT) in patients undergoing orthopedic, abdominal, or pelvic surgery.
Treatment of DVT and pulmonary embolism (PE).
Reduction of the risk of ischemic complications in patients with acute coronary syndrome (unstable angina, non-Q-wave myocardial infarction).
Prevention of clot formation in patients undergoing percutaneous coronary intervention (PCI).
Treatment of acute ST-segment elevation myocardial infarction (STEMI) in combination with thrombolytic therapy.

Dosage of Lovenox

The dosage of Lovenox depends on the specific medical condition being treated and the patient’s weight. The recommended dosage ranges for various indications are as follows:

DVT prophylaxis: 40 mg once daily or 30 mg twice daily.
Treatment of DVT or PE: 1 mg/kg every 12 hours or 1.5 mg/kg once daily.
Acute coronary syndrome: 1 mg/kg every 12 hours or 0.75 mg/kg every 12 hours (with concomitant aspirin).
STEMI treatment: 30 mg IV bolus plus a 1 mg/kg SC dose, followed by 1 mg/kg SC every 12 hours (maximum 100 mg for the first two doses).

It’s important to follow the healthcare provider’s instructions and to not adjust the dosage without consulting them.

Side Effects of Lovenox

Lovenox, like any medication, can cause side effects. The most common side effects include:

Bleeding or bruising at the injection site
Nausea
Headache
Fatigue
Elevated liver enzymes

In rare cases, Lovenox can also cause more serious side effects, such as severe bleeding, heparin-induced thrombocytopenia (HIT), and osteoporosis with long-term use. Patients should report any unusual symptoms to their healthcare provider immediately.

Lovenox Interactions

Lovenox can interact with a variety of medications, diseases, and other factors. Some of the most significant interactions include:

Drug Interactions

Lovenox may interact with the following medications:

Anticoagulants (e.g., warfarin, direct-acting oral anticoagulants)
Antiplatelet drugs (e.g., aspirin, clopidogrel)
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Selective serotonin reuptake inhibitors (SSRIs)
Certain antibiotics (e.g., ciprofloxacin, doxycycline)
Corticosteroids

Concurrent use of these medications with Lovenox may increase the risk of bleeding or other complications. Healthcare providers should carefully monitor patients and adjust dosages as needed.

Disease Interactions

Lovenox should be used with caution in patients with the following conditions:

Bleeding disorders (e.g., hemophilia)
Liver disease
Kidney disease
High blood pressure
Active bleeding
Thrombocytopenia (low platelet count)

In these cases, healthcare providers may need to adjust the dosage or closely monitor the patient’s condition.

Alcohol and Food Interactions

Patients taking Lovenox should avoid consuming alcohol, as it may increase the risk of bleeding. Additionally, certain foods high in vitamin K, such as leafy green vegetables, may interact with Lovenox and affect its anticoagulant effects.

Warnings and Precautions

Patients should be aware of the following warnings and precautions when taking Lovenox:

Increased risk of bleeding, especially in patients with a history of bleeding or other risk factors
Increased risk of spinal or epidural hematoma in patients undergoing neuraxial anesthesia or spinal puncture
Potential for osteoporosis with long-term use
Contraindication in patients with active major bleeding or known hypersensitivity to Lovenox or heparin

Patients should inform their healthcare providers of all their medical conditions and medications to ensure the safe and effective use of Lovenox.

Conclusion

Lovenox is a widely used anticoagulant medication with a range of approved uses. Understanding the proper dosage, potential side effects, and various interactions is crucial for the safe and effective use of this medication. Patients should work closely with their healthcare providers to ensure the optimal management of their condition while taking Lovenox.

Lovenox Interactions Checker – Drugs.com

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There are 192 drugs known to interact with
Lovenox (enoxaparin), along with
12 disease interactions, and 2 alcohol/food interactions.

Of the total drug interactions,
94 are major, 92 are moderate, and 6 are minor.

Does Lovenox interact with my other drugs?

Enter other medications to view a detailed report.

View all 192 medications that may interact with Lovenox
View Lovenox alcohol/food interactions (2)
View Lovenox disease interactions (12)

Most frequently checked interactions

View interaction reports for Lovenox (enoxaparin) and the medicines listed below.

Major
Moderate
Minor
Unknown

albuterol
amlodipine
aspirin
Colace (docusate)
Coumadin (warfarin)
Fish Oil (omega-3 polyunsaturated fatty acids)
furosemide
gabapentin
hydrochlorothiazide
Lasix (furosemide)
levothyroxine
Lipitor (atorvastatin)
lisinopril
losartan
metformin
metoprolol
multivitamin
omeprazole
oxycodone
potassium chloride
prednisone
Protonix (pantoprazole)
simvastatin
Synthroid (levothyroxine)
tramadol
Tylenol (acetaminophen)
Vitamin C (ascorbic acid)
Vitamin D3 (cholecalciferol)
warfarin
Zofran (ondansetron)

Lovenox alcohol/food interactions

There are 2 alcohol/food interactions with Lovenox (enoxaparin).

Lovenox disease interactions

There are 12 disease interactions with Lovenox (enoxaparin) which include:

hemophilia
liver disease
peptic ulcer disease
retinopathy
subacute bacterial endocarditis
active bleeding
hypertension
renal dysfunction
thrombocytopenia
prematurity
hypertension
kidney disease

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More about Lovenox (enoxaparin)

Lovenox consumer information
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Pricing & coupons
Reviews (20)
Latest FDA alerts (5)
Side effects
Dosage information
During pregnancy
Generic availability
Support group
Drug class: heparins
Breastfeeding
En español

Related treatment guides

Acute Coronary Syndrome
Angina
Deep Vein Thrombosis
Deep Vein Thrombosis Prophylaxis after Abdominal Surgery

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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