Mavik Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), fainting.

Although trandolapril may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause kidney problems or make them worse. Your doctor will check your kidney function while you are taking this medication. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Mavik – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Trandolapril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It is used to treat mild-to-moderate high blood pressure. It works by relaxing blood vessels, allowing the heart to pump more efficiently. It is also used after heart attacks to reduce the risk of another heart attack and prevent the onset or worsening of congestive heart failure.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.  If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

0.5 mg
Each red opaque body and yellow opaque cap, No. 4 gelatin capsule, contains 0.5 mg of trandolapril. Nonmedicinal ingredients: lactose, maize starch, povidone, and sodium stearyl fumarate; capsule cap and body: erythrosine, iron oxides and hydroxides, sodium lauryl sulfate, and titanium dioxide.

1 mg
Each red opaque body and orange opaque cap, No. 4 gelatin capsule, contains 1 mg of trandolapril. Nonmedicinal ingredients: lactose, maize starch, povidone, and sodium stearyl fumarate; capsule cap and body: erythrosine, iron oxides and hydroxides, sodium lauryl sulfate, and titanium dioxide.

2 mg
Each red opaque body and red opaque cap, No. 4 gelatin capsule, contains 2 mg of trandolapril. Nonmedicinal ingredients: lactose, maize starch, povidone, and sodium stearyl fumarate; capsule cap and body: erythrosine, iron oxides and hydroxides, sodium lauryl sulfate, and titanium dioxide.

4 mg
Each red opaque body and brown opaque cap, No. 4 gelatin capsule, contains 4 mg of trandolapril. Nonmedicinal ingredients: lactose, maize starch, povidone, and sodium stearyl fumarate; capsule cap and body: erythrosine, iron oxides and hydroxides, sodium lauryl sulfate, and titanium dioxide.

How should I use this medication?

For treatment of high blood pressure, the recommended adult starting dose is 1 mg once daily with increases in dose every 2 to 4 weeks until blood pressure is controlled. The maximum recommended dose is 4 mg once daily. After a heart attack, the recommended starting dose is 1 mg once daily starting no earlier than the third day after the heart attack has taken place. After 2 days, the recommended dose is increased to 2 mg once daily and after one month, the recommended dose is increased to 4 mg once daily if the medication is tolerated.

Trandolapril may be taken with or without food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take trandolapril if you:

• are allergic to trandolapril or any ingredients of the medication
• are allergic to any other ACE inhibitors
• are pregnant or plan to become pregnant
• are breast-feeding
• are taking the medication sacubitril – valsartan
• are taking the medication aliskiren or another ACE inhibitor or an angiotensin receptor blocker (ARB) and have one of the following conditions:
• diabetes
• kidney disease
• high levels of potassium in the blood
• have congestive heart failure combined with low blood pressure
• have been diagnosed with hereditary angioedema
• have severely low blood pressure
• have any condition that makes you intolerant to lactose
• have had angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any other ACE inhibitors (e. g., captopril, ramipril)
• have narrowing of the blood vessels in the kidneys

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• cough (dry, persistent)
• diarrhea
• dizziness
• fatigue
• headache
• loss of appetite
• nasal stuffiness
• nausea
• unusual tiredness
• vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• confusion
• flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
• numbness or tingling in hands, feet, or lips
• signs of bleeding (e.g., unusual nosebleeds, blood in urine, coughing blood, bruising easily, cuts that won’t stop bleeding)
• signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• signs of fluid and electrolyte imbalance (e.g., drowsiness, muscle pain or cramps, weakness, irregular heartbeat)
• signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs of liver problems (e. g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of low blood pressure (e.g., dizziness, lightheadedness, fainting)
• signs of too much potassium in the body (e.g., confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs)
• skin rash, with or without itching, fever, or joint pain

Stop taking the medication and seek immediate medical attention if any of the following occur:

• abdominal pain, with or without nausea or vomiting
• signs of angioedema (e.g., swollen mouth, lips, tongue, difficulty swallowing or breathing)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed.  Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Angioedema: Angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) may occur with trandolapril, although uncommonly. Angioedema may also affect the digestive system. If swelling of the face, tongue, or glottis occurs, or you experience unexpected abdominal pain that may be accompanied by nausea or vomiting, stop the medication at once and seek immediate medical attention. If you experience angioedema with trandolapril, you should not take any of the other ACE inhibitors, such as enalapril, lisinopril, or quinapril.

People who have had angioedema caused by other substances may be at increased risk of angioedema while taking an ACE inhibitor such as trandolapril.

Blood disorders: In rare cases, a low white blood cell count has been reported by people taking this medication. Your doctor may occasionally monitor your level of white blood cells by performing blood tests. Low white blood cell levels may increase your risk for infection. If you notice any signs of infection (e.g., fever, sore throat), contact your doctor as soon as possible.

Cough: People taking trandolapril may develop a dry, persistent cough that usually disappears only after stopping or lowering the trandolapril dose. Be sure to tell your doctor of any cough which does not seem to be related to a usual cause.

Dizziness/reduced alertness: Trandolapril can cause side effects such as dizziness, drowsiness, headache or fatigue that may reduce alertness, especially when you first start to take this medication. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by this medication.

Fluid and electrolyte balance: Increases in blood levels of potassium may occur as a result of taking trandolapril. This rarely causes problems, but your doctor will probably want to monitor your potassium levels regularly with blood tests. If you experience unexplained nausea, fatigue, muscle weakness, or tingling sensations, contact your doctor.

Kidney function: Certain people who take this medication may experience changes in kidney function. Some people may be more likely to experience changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), aliskiren, or nonsteroidal anti-inflammatory drugs (NSAIDs), may further increase risk of kidney problems for those at risk for this problem. If you have kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

This medication may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, blood pressure drops too low after taking trandolapril. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur for those who take aliskiren, water pills, have a salt restricted diet, are on dialysis, or are experiencing diarrhea or vomiting. These individuals should be monitored closely by their doctor for the first weeks of treatment and whenever the dose of the medication is increased. To reduce the risk of dizziness, get up slowly from a lying down or sitting position. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Excessive sweating and lack of fluid intake may lead to an excessive fall in blood pressure because of reduced fluid in your blood vessels. Vomiting or diarrhea may also lead to a fall in blood pressure. Consult your doctor if you feel your blood pressure is too low.

Pregnancy: ACE inhibitors such as trandolapril may cause severe harm or death to a developing baby if taken by the mother during pregnancy. This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking trandolapril, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors may have an increased risk of experiencing side effects when taking trandolapril due to reduced kidney function. Lower doses may be necessary to minimize side effects.

What other drugs could interact with this medication?

There may be an interaction between trandolapril and any of the following:

• acetylsalicylic acid (ASA)
• alcohol
• aldesleukin
• aliskiren
• allopurinol
• alpha-agonists (e.g., clonidine, methyldopa)
• alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
• amifostine
• amphetamines (e. g., dextroamphetamine, lisdexamfetamine)
• angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
• angiotensin II receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)
• antacids (e.g., calcium carbonate, magnesium hydroxide)
• azathioprine
• barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• brimonidine
• calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
• cyclosporine
• dexmethylphenidate
• diabetes medications (e.g., canagliflozin, chlorpropamide, glipizide, glyburide, insulin, metformin,  rosiglitazone)
• diazoxide
• dipyridamole
• diuretics (water pills; e.g., furosemide, amiloride, spironolactone, triamterene)
• drospirenone
• duloxetine
• eplerenone
• everolimus
• gold salts
• grass pollen allergen extract
• guanfacine
• heparin
• iron dextran
• iron gluconate
• levodopa
• lithium
• low molecular weight heparins (e. g., dalteparin, enoxaparin, tinzaparin)
• medications that increase blood levels of potassium (e.g., potassium chloride, salt substitutes containing potassium)
• medications that lower blood pressure
• methylphenidate
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., indomethacin)
• obinutuzumab
• pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
• pregabalin
• sacubitril
• second generation anti-psychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
• sirolimus
• sodium phosphates
• tacrolimus
• temsirolimus
• tizanidine
• tolvaptan
• trimethoprim
• yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Mavik

Trandolapril – an ACE inhibitor.

Side effects and dosage.

About trandolapril

Trandolapril belongs to a class of medicines called angiotensin-converting enzyme (ACE) inhibitors. You may be prescribed it to reduce high blood pressure (hypertension), or to protect your heart and blood vessels from further damage following a heart attack. Your doctor will tell you why it has been prescribed for you.

ACE inhibitors like trandolapril prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. This widens your blood vessels and helps to reduce the amount of water put back into your blood by your kidneys. These actions help to reduce high blood pressure. People with high blood pressure often do not feel unwell but, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke.

Trandolapril also has a protective effect on the heart in people who have recently had a heart attack.

Before taking trandolapril

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking trandolapril it is important that your doctor knows:

• If you are pregnant or breastfeeding.
• If you have any problems with the way your kidneys work, or any problems with the way your liver works.
• If you are lacking in fluid in the body (dehydrated) – for example, if you have had diarrhoea or sickness very recently.
• If you have been told you have a build-up of fatty deposits on the walls of your arteries, a condition called atherosclerosis.
• If you have a particular type of poor circulation called peripheral arterial disease.
• If you have collagen vascular disease – this includes conditions such as systemic lupus erythematosus (SLE) and scleroderma.
• If you have been told you have heart muscle disease (cardiomyopathy), or narrowing of the main blood vessel from your heart (aortic stenosis).
• If you have ever had a reaction where your face, tongue or throat swells (angio-oedema).
• If you are having desensitisation treatment to protect against bee and wasp stings.
• If you are having dialysis treatment, or treatment to remove cholesterol from your blood by a machine (LDL apheresis).
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
• If you have ever had an allergic or unusual reaction to any other ACE inhibitor (such as captopril, lisinopril, ramipril or perindopril), or to any other medicine.

How to take trandolapril

• Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about trandolapril and will provide you with a full list of side-effects which you could experience from taking it.
• Take the capsules exactly as your doctor tells you to. Trandolapril is taken once a day. Your doctor may advise you to take your very first dose at bedtime. This is because you may feel dizzy when you first start taking it. With the exception of the first dose, you can generally take trandolapril at a time of day you find easy to remember. For most people this will be in the morning.
• Try to take your doses at the same time of day each day as this will help you to remember to take your doses regularly. You can take the capsule either with or without food. It is best to swallow the capsule with a drink of water. Do not open or chew the capsules.
• There are several strengths of trandolapril capsules – 500 micrograms, 2 mg and 4 mg. It is usual to start with a low strength and then for the strength to be increased as necessary after a few weeks. This allows your doctor to make sure that you have the dose that helps your condition, but helps avoid unwanted side-effects. Each time you collect a new supply of trandolapril, check to make sure it contains the strength of capsule that you are expecting.
• If you forget to take a capsule at your usual time, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

• Try to keep your regular appointments with your doctor. This is so your progress can be monitored. Your doctor will want you to have some blood tests from time to time to check that your kidneys are working well.
• It is very important that you follow any dietary and lifestyle advice that you have been given by your doctor. This can include advice about eating a healthy diet, not smoking, and taking regular exercise.
• If you buy any medicines, check with a pharmacist that they are suitable to take with trandolapril. This is because some medicines (such as anti-inflammatory painkillers and indigestion remedies) can interfere with your treatment.
• It is likely that your doctor will advise that you do not use salt substitutes while you are taking trandolapril. These products have a high content of potassium which could be harmful for you.
• If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on trandolapril. Alcoholic drinks can make you feel light-headed or dizzy, and they may not be advisable for you.
• If you have diabetes you may need to check your blood sugar (glucose) more frequently, as the capsules can lower the levels of sugar in your blood. Your doctor will advise you about this.
• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking trandolapril. This is because some anaesthetics could cause your blood pressure to drop too low.
• Treatment with trandolapril is often long-term unless you experience an adverse effect. Continue to take the capsules unless you are advised otherwise by your doctor.

Can trandolapril cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with trandolapril. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer’s printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer’s information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common trandolapril side-effects (these affect less than 1 in 10 people)	What can I do if I experience this?
Dry irritating cough	If this continues, speak with your doctor, as a different type of medicine may be more suitable for you
Feeling dizzy or tired	Getting up more slowly should help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing. If this continues beyond the first few days, speak with your doctor. Do not drive and do not use tools or machines while affected
Headache	Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
Feeling sick (nausea), diarrhoea	Stick to simple foods – avoid fatty or spicy meals
Kidney problems	Your doctor will check for this

Important: if you experience any of the following rare but serious symptoms, stop taking trandolapril and contact your doctor for advice straightaway:

• Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.
• Any yellowing of your skin or the whites of your eyes. These can be signs of a liver problem called jaundice, which is a rare side-effect.

If you experience any other symptoms which you think may be due to the capsules, speak with your doctor or pharmacist for further advice. 

How to store trandolapril

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Memorial Sloan Kettering Cancer Center

This information from Lexicomp^® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: Canada

AURO-Trandolapril; Mavik; Odrik; PMS-Trandolapril; SANDOZ Trandolapril; TEVA-Trandolapril

Warning

• Do not take if you are pregnant. Use during pregnancy may cause birth defects or loss of the unborn baby. If you get pregnant or plan on getting pregnant while taking this drug, call your doctor right away.

What is this drug used for?

• It is used to treat high blood pressure.
• It is used to help heart function after a heart attack.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have ever had a very bad or life-threatening reaction called angioedema. Signs may be swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; unusual hoarseness.
• If you are taking a drug that has aliskiren in it and you also have diabetes or kidney problems.
• If you have taken a drug that has sacubitril in it in the last 36 hours.
• If you are breast-feeding. Do not breast-feed while you take this drug.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

• Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• Check your blood pressure as you have been told.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
• If you are on a low-salt or salt-free diet, talk with your doctor.
• Low white blood cell counts have happened with captopril, a drug like this one. This may lead to more chance of getting an infection. Most of the time, this has happened in people with kidney problems, mainly if they have certain other health problems. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
• If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and some natural products or aids.
• Talk with your doctor before you drink alcohol.
• Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
• Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. This may lead to low blood pressure.
• This drug may not work as well to lower blood pressure in Black patients. Sometimes another drug may need to be given with this drug. If you have any questions, talk with the doctor.
• A severe and sometimes deadly reaction called angioedema has happened. The chance of angioedema may be higher in Black patients.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
• Very bad dizziness or passing out.
• Very bad belly pain.
• Very upset stomach or throwing up.
• Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take this drug at the same time of day.
• Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

• Store at room temperature in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. The use of this information is governed by the Lexicomp End User License Agreement, available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Last Reviewed Date

2020-06-04

Copyright

© 2021 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Diabetes Clinic

Trandolapril tablets

What is this medicine?

TRANDOLAPRIL (tran DOLE a pril) is an ACE inhibitor. This medicine is used to treat high blood pressure. It is also used to treat patients who have heart failure following a heart attack.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Mavik

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• bone marrow disease
• heart or blood vessel disease
• if you are on a special diet, such as a low salt diet
• immune system disease like lupus
• kidney or liver disease
• low blood pressure
• previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
• an unusual or allergic reaction to trandolapril, other ACE inhibitors, insect venom, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medication with any of the following medications:

This medicine may also interact with the following:

• diuretics
• lithium
• medicines for high blood pressure
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• potassium salts or potassium supplements

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. Call your doctor or health care professional if you notice an irregular or fast heart beat.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash or hives, swelling of the hands, feet, face, lips, throat, or tongue
• chest pain
• decreased amount of urine passed
• difficulty breathing, or difficulty swallowing
• dizziness, light headedness or fainting spells
• fever or chills
• numbness or tingling in your fingers or toes
• nausea and vomiting
• stomach or abdominal pain
• swelling of your legs or ankles

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• cough
• decreased sexual function or desire
• diarrhea
• headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Mavik (trandolapril) dosing, indications, interactions, adverse effects, and more

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ^® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

Trade names: Canada

AURO-Trandolapril; Mavik; Odrik; PMS-Trandolapril; SANDOZ Trandolapril; TEVA-Trandolapril

Warning

• Not for use by pregnant women.The use of the drug during pregnancy can cause birth defects or intrauterine death of the child. If you become pregnant or plan to become pregnant while taking this drug, call your doctor right away.

What is this drug used for?

• Used to treat high blood pressure.
• It is used to improve the functioning of the heart after a heart attack.
• This medicinal product may also be used for other indications.Consult your doctor.

What do I need to tell my doctor BEFORE taking this drug?

• If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.
• If you have ever had a serious allergic reaction called angioedema (angioedema). Symptoms include swelling of the hands, face, lips, tongue, or throat; breathing disorder; swallowing disorder; uncharacteristically hoarse voice.
• If you are taking a drug containing aliskiren if you have diabetes or kidney disease.
• If you have taken a preparation containing sacubitrile in the past 36 hours.
• If you are breastfeeding. Do not breast-feed while taking this drug.

This list of drugs and diseases that may be adversely associated with this drug is not exhaustive.

Tell your doctor and pharmacist about all the medicines you take (both prescription and over-the-counter, natural products and vitamins) and your health problems.You need to make sure that this drug is safe for your medical condition and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

• Tell all healthcare providers that you are taking this drug.These are doctors, nurses, pharmacists and dentists.
• Avoid driving or other activities that require increased attention until you see how this drug affects you.
• To reduce the risk of dizziness or loss of consciousness, get up slowly from a lying or sitting position. Use caution when climbing and descending stairs.
• Check blood pressure as directed.
• Perform blood tests as directed by your doctor.Please consult your doctor.
• If you are using a salt substitute containing potassium, a potassium-sparing diuretic, or a potassium supplement, consult your doctor.
• Consult your doctor if you are on a salt-free or low-salt diet.
• With the use of captopril (a drug similar to this drug), a low level of leukocytes was noted. This can lead to an increased risk of infection.Most of the time, this has happened in people with kidney problems, mostly with some other health problem. See your doctor right away if you have symptoms of an infection such as high fever, chills, or sore throat.
• If you are taking this drug and have high blood pressure, talk to your doctor before taking any over-the-counter drugs that can raise blood pressure. These drugs include medicines for coughs and colds, diet pills, stimulants, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, and some naturally occurring drugs.
• Consult a physician before drinking alcohol.
• Exercise caution in hot weather and during vigorous activity. Drink plenty of fluids to stay hydrated.
• Tell your doctor if you experience excessive sweating, fluid loss, vomiting, or loose stools. This can lead to a drop in blood pressure.
• The ability of this drug to lower blood pressure may be less pronounced in Blacks.In some cases, you may need to take another drug at the same time in addition to this drug. If you have any questions, please consult your doctor.
• A serious and sometimes fatal reaction called angioedema has occurred. The risk of developing angioedema may be increased in the Negroid race.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can have serious and sometimes deadly side effects. Call your healthcare professional or get medical attention right away if you have any of the following signs or symptoms, which may be associated with serious side effects:

• Signs of an allergic reaction such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
• Signs of kidney problems, including lack of urination, change in urine volume, blood in the urine, or rapid weight gain.
• Signs of elevated potassium levels such as a feeling of a disturbed heartbeat, confusion, feeling weak or dizzy, feeling light-headed, feeling numb or tingling, or shortness of breath.
• Severe dizziness or fainting.
• Severe abdominal pain.
• Severe nausea or vomiting.
• Liver dysfunctions have been reported while taking drugs of this kind. Sometimes these cases were fatal. Call your doctor right away if you have signs of liver dysfunction, such as dark urine, tired feeling, lack of appetite, nausea or abdominal pain, light colored stools, vomiting, yellow skin or eyes.

What are some other side effects of this drug?

Any medicine can have side effects.However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

• Cough.
• Dizziness.

This list of potential side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you. Follow all instructions strictly.

• Take this drug at about the same time of the day.
• Continue taking this drug as directed by your doctor or other healthcare professional, even if you feel well.
• Drink plenty of decaffeinated fluids, unless your doctor tells you to drink less fluids.

What should I do if a dose of a drug is missed?

• Take the missed dose as soon as you can.
• If it is time for your next dose, do not take the missed dose and then return to your normal dose schedule.
• Do not take 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

General information on medicinal products

• If your health does not improve or even worsens, see your doctor.
• You should not give your medicine to anyone or take someone else’s medicine.
• Some medicines may have different patient information sheets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• Some medicines may come with other patient information sheets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• If you think there has been an overdose of a drug, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Use of information by the consumer and limitation of liability

This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are suitable for a particular patient.This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient. Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional.Check with your doctor for complete information on the possible risks and benefits of taking this drug. Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Copyright

© UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

Mavik Tablet in English – Item

Accessories (Mavic Pro) – Page 122 – Mavic Pro

https: //ru.aliexpres…0308.0.0.POq673 replacement of the original car charger is much cheaper.

This one charges me up to 95-98%, no more ((

Added later (12 April 2018 – 16:32)

phone is evil, you fly and they call you…..

I answer on the headset, and the subscriber’s number is on the side screen. But 5-6 “is still not enough, 10” is needed at least. Today came this https: //ru.aliexpres…2311.0.0.YGouC0

Added later (12 April 2018 – 16:38)

https: //ru.aliexpres…iceBeautifyAB=0 Somehow it is suspiciously cheap for a charger that charges so many batteries at the same time.

Came for ~ 620 rubles. such https: // ru.aliexpres … 2311.0.0.YGouC0 for 3 batteries, I’ll see in the evening how it charges

in parallel

Added later (12 April 2018 – 18:13)

I would like to say separately about the polaric (polarizing filter). Indeed, this is a wonderful filter, but absolutely not suitable for shooting from the air.

Works great from the air, set it up and that’s it.

Added later (12 April 2018 – 18:16)

So the polaric is adjusted by turning the filter, that is, the filter itself needs to be turned and in real time select the most correct angle of rotation when the reflections disappear.

Other settings of the polar explorer are in real time:

If you turn the circular polarizing filter backwards, you can get a neutral filter, when you rotate such a filter around its axis, you can shift the white balance to warm and cold tones, while the polarizing filter stops blocking polarized light.

Tilt-shift lens effect / CopterTime’s blog / Habr

There is something attractive about tiny things, they are fascinating in nature.Tilt-shift photography is a great example of how large real-life objects can be made into miniature works of art.

Tilt-shift is a type of photography where you can manipulate focus and depth of field to produce photographs that simulate miniature models by selectively focusing.

The effect can be achieved with special Tilt-shift lenses, but you can also simulate this effect in post-processing in Photoshop.

If you don’t want to spend $ 2,500 on a lens like this to get the effect you want, here are some tips to help you do it with Photoshop CC.

In addition to the actual retouching and software, I will give some tips for getting the most suitable source images.

There are several ways to get a tilt-shift effect using Photoshop CC, but we will use a simple method that will give exactly the same results as using specialized equipment.

1. Choose the most suitable image

Choose a high vantage point (in your DJI Mavic Pro, Mavic Air or Phantom 4, I think it will be easy for you to do this) to achieve the atmosphere of the model (we always look on the model from a height). Choose a photo with enough detail, lots of elements and few blank spaces to give your photo a more impact.

2. Step two

In the “layers” menu, right-click on the preview, in the drop-down menu select “convert to smart object”.

3. Step three

Now in the top menu, click “filter”, then the pointer to the “blur gallery”, then select “tilt-offset”.

4. Step four

There are 2 panels on the right side of the screen: basic blur tools at the top with tilt-shift filter options and settings and a blur panel at the bottom with some additional bokeh settings.

To move the field of focus, simply click in the center and drag to a new location, then release the mouse button.To change the strength of the impact, click on the “button” and you can move the lines up and down to change the place of the blur.

5. Step five

You can solve it differently, but I choose “symmetric distortion”

6. Step six

Select the “high quality” option for better detail … To achieve the most “toy” effect, it might make sense to tweak the colors a little (maybe add a little saturation).Top menu-image-correction-hue / saturation. Another important step to keep in mind is the correction of the brightness curves. Top menu-image-correction-curves. And finally, the last step is to add sharpness. I recommend cropping the image a little to remove all unnecessary surroundings for a more tilt-shift effect.

When it comes to colors, curves and sharpening, don’t overdo it.

I hope these short tips will help you discover a new and enjoyable way of shooting and then add a tilt-shift effect to some of your photos.

Thank you for reading, enjoy flying with your drone.

ps: The tilt-shift effect does not only work in photography, you can also use this technique with your video material. I’m using Final Cut Pro X, which makes it easy to add this effect to your footage as well.

Examples of photo processing

Dominican Church

Crossroads

Embankment

Uluwatu Rock

Nusa Dua Beach

Church

Rice

Church

Rice

Terraces

Pandawa Pier part II

instructions, composition, dosage, side effects

NOXA 20 is an anti-inflammatory drug that is prescribed for various types of arthritis, including osteoarthritis, rheumatoid arthritis, gout and ankylosing spondylitis.

NOXA 20 Instructions for use

1. Composition:

Each capsule contains 20 mg of piroxicam.

2. Description

NOXA 20 is an anti-inflammatory drug designed to relieve pain, swelling and stiffness caused by arthritis. It can be used for various types of arthritis, including osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.

Piroxicam is also sometimes used to relieve pain caused by menstrual cramps, postoperative pain.

This drug belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). It works by stopping certain substances in the body that can cause inflammation.

3. Precautions

Taking NOXA 20 may increase the risk of heart attack or stroke, especially in people who have cardiovascular disease or who have been taking medication for a long time.

This medicine may increase the risk of stomach ulcers and bleeding.These problems can be serious and sometimes fatal.

Do not take piroxicam before or immediately after heart surgery.

Before taking NOXA 20, tell your doctor if you or anyone in your family has had the following conditions:

• Heart disease.
• Heart attack.
• High blood pressure.
• Diabetes.
• High cholesterol.
• Asthma.
• Polyps in the sinuses.
• Swelling of hands, feet, ankles or lower legs.
• Liver disease.
• Kidney disease.
• Problems with the gastrointestinal tract or intestinal bleeding.
• Low blood sodium levels.
• History of alcohol abuse.
• Allergy to medicines.

Elderly people and those who take NSAIDs for a long time are at greater risk of developing gastrointestinal diseases.Drinking alcohol can also increase your risk of bleeding or stomach ulcers.

3.1. Pregnancy and lactation

Do not take NOXA 20 if pregnant or nursing without your doctor’s approval.

3.2. Impact on vehicle management

Piroxicam may cause dizziness or drowsiness. Do not drive or operate vehicles if you experience similar effects.

3.3. Consumption of alcohol and tobacco

The use of alcohol or tobacco products may increase the risk of serious side effects while taking the drug.

4. Side effects:

Get medical attention if you experience any of the following side effects:

• Shortness of breath.
• Chest pain.
• Weakness on one side of your body.
• Slurred speech.
• Abdominal pain.
• Heartburn.
• Vomit that looks like coffee grounds.
• Bloody or black stools.
• Diarrhea or constipation.
• Gases.
• Dizziness.
• Ringing in the ears.
• Headache.
• Vision problems.
• Unexplained weight gain.
• Joint pain.
• High temperature.
• Rash, itching or hives.
• Difficulty breathing or swallowing.
• Swelling of the face, eyes, lips, tongue, throat, hands, arms, legs, ankles or lower legs.
• Hoarseness.
• Pale skin.
• Excessive fatigue.
• Rapid heartbeat.
• Unusual bleeding or bruising.
• Loss of appetite.
• Pain in the upper right side of the stomach.
• Flu symptoms.
• Yellowing of the eyes or skin.
• Back pain.
• Difficulty or painful urination.
• Discolored, cloudy, or bloody urine.

5. Interaction with other medicinal products:

Before taking NOXA 20, tell your doctor if you are taking any of the following medicines:

• Anticoagulants (blood thinners) such as Warfarin (Coumadin, Yantoven).
• Aspirin.
• Other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn).
• Oral steroids such as dexamethasone (decadron, dexon), methylprednisolone (medrol), and prednisone (deltazone).
• Angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotenzin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univopril) (Acenivin), percenone ramipril (Altace) and trandolapril (Mavik).
• Diuretics.
• Lithium (Escalite, Lithobid).
• Medicines for diabetes.
• Methotrexate (Rheumatrex).
• Phenytoin (dilantin).

Also, tell your doctor if you have ever had ulcers, stomach bleeding, gastritis, or other bleeding problems.

6. Method of application and dosage

Take the medicine 1-2 times a day for 5-12 days, or as recommended by your doctor.Take the capsules with a glass of water.

NOXA 20 can be taken with food in order not to harm the stomach.

Carefully follow the instructions in the prescription on the package of the medicine, or as directed by your doctor.

6.1. Overdose:

Overdose symptoms may include:

• Sleepiness.
• Upset stomach or abdominal pain.
• Vomiting.
• Lack of energy.
• Bloody, black, or tarry stools.
• Vomit that looks like coffee grounds.
• Coma.
• Difficulty breathing.

If you suspect you have an overdose, go to the emergency room immediately.

6.2. If you forget to take the drug on time

Do not double doses to make up for the missed dose.

7. Storage conditions:

Store in closed containers at room temperature, out of reach of children.

8. Country of origin:

Thailand

Instructions for the use of medicines are posted on this site for information purposes. Remember that medications should only be taken on the advice of a doctor.

If you have used this medicine, please leave your feedback below.

90,000 AstraZeneca vaccine startup to IPO in the US

ALL NEWS

Apr 7, 2021

WSJ: AstraZeneca vaccine startup to IPO in the US

NEW YORK, April 7./ TASS /. UK-based Vaccitech, which helped develop a coronavirus vaccine for UK-Sweden company AstraZeneca, is planning an initial public offering (IPO) in the United States this week. This was reported on Wednesday by The Wall Street Journal, citing sources.

According to her, the company, created in 2016, co-founded by scientists from the University of Oxford, can be valued at $ 700 million with a potential increase to $ 1 billion by the end of the year.Company executives want the company’s shares to trade on the Nasdaq electronic exchange. Several of the company’s current investors are expected to participate in the IPO process.

Vaccitech plans to use the technology that became the basis for the coronavirus vaccine to develop drugs for prostate cancer, hepatitis B and human papillomavirus.

The AstraZeneca vaccine is one of the most popular in the world: it was allowed to be used by more than 90 countries (including within the framework of the international COVAX mechanism, and the volume of pre-orders for the drug reaches about 2.5 billion doses.Some world leaders decided to be vaccinated with this particular vaccine, in particular, the presidents of Ukraine and South Korea, Volodymyr Zelenskyy and Moon Jae In, the Prime Ministers of Great Britain and Italy, Boris Johnson and Mario Draghi.

Currently, the drug is still awaiting approval from the Food and Drug Administration under the US Department of Health and Human Services (FDA), but the company has already produced tens of millions of doses throughout the country. At the same time, the director of the National Institute of Allergic and Infectious Diseases of the United States, Anthony Fauci, expressed the opinion that the United States could vaccinate in the country without using the AstraZeneca vaccine.In addition, the company’s drug faced a number of challenges, including a shortage of production, as well as a potential side effect associated with the formation of blood clots.

Source: https://tass.ru/ekonomika/11092705

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DRUGS ACE INHIBITORS IN THE TREATMENT OF ARTERIAL HYPERTENSION

Drugs ACE inhibitors in the treatment of arterial hypertension – Assuta Hospital, Tel Aviv, Israel

Enam – a representative of the class of drugs ACE inhibitors – treatment in the clinic Assuta

Preparations ACE inhibitors.

ACE inhibitors include:

• Kapoten (captopril).
• Enam (enap, enalopril, vazotec).
• Privil (lisinopril).
• Lotenzil (benazepril).
• Monopril (fosinopril).
• Altais (ramipril).
• Accupril (quinopril).
• Aseon (perindopril).
• Mavic (trandolapril).
• Univask (moexipril).

The action of ACE inhibitor drugs is associated with inhibition of the synthesis in the kidneys of angiotensin, a substance that constricts blood vessels.It is formed from renin under the action of a special enzyme. ACE inhibitors block this enzyme. ACE inhibitors also reduce blood flow to the heart, which reduces stress on the heart and also protects the kidneys from the effects of hypertension and diabetes.

In addition to arterial hypertension, ACE inhibitors are used for the treatment of some concomitant heart diseases, including heart failure, myocardial infarction, as well as for the prevention of kidney pathology due to hypertension and diabetes.

Rules for taking ACE inhibitors.

ACE inhibitors should be taken on an empty stomach 1 hour before meals. The frequency of taking the drug, the dosage and the interval between doses are indicated by the doctor.

Do not take salt substitutes during treatment with ACE inhibitors. They contain potassium, and ACE inhibitors can cause potassium retention in the body. It is recommended that you avoid eating large amounts of potassium-rich foods. This does not mean that you need to completely abandon them, but consuming them in large quantities is not recommended.

Avoid taking non-steroidal anti-inflammatory drugs such as nurofen, brufen, etc., as they lead to sodium and water retention in the body, which can reduce the effectiveness of ACE inhibitors.

Regularly monitor blood pressure and renal function during treatment with ACE inhibitors.

Never stop taking these drugs on your own, even if you feel they are not helping to lower your high blood pressure, without your doctor’s supervision. If ACE inhibitors have been prescribed to you for the treatment of heart failure, the symptoms of this disease may not go away immediately, but only after a certain time.However, a long course of ACE inhibitors can be very effective in treating heart failure.

Is it possible to take ACE inhibitors for children.

Yes. However, children are much more sensitive to the blood pressure effects of these drugs. Therefore, the risk of side effects in them is much higher than in adults.

ACE inhibitors and pregnancy.

The use of ACE inhibitors during pregnancy is not recommended, especially in the second and third trimester.These drugs can lower blood pressure, as well as impair kidney function and increase the level of potassium in a pregnant woman’s body. They can lead to fetal death or abnormalities.

If a woman takes ACE inhibitors after childbirth, it is not recommended to breastfeed the baby, as these drugs are excreted in milk.

Side effects of ACE inhibitors.

• Dizziness and weakness. This side effect may be most pronounced after the first dose of the drug, especially if you are taking diuretics at the same time.
• Swelling of the neck, face and tongue.
• Salty or metallic taste in the mouth. Usually, this effect gradually goes away on its own.
• Cough. If this symptom persists, see your doctor.
• Renal dysfunction. Although the use of ACE inhibitors for hypertension has a positive effect on the kidneys, they can also have a negative effect.
• Redness and itching of the skin.
• Physical symptoms such as sore throat, fever, stomatitis, bruising, heart palpitations, chest pain, and leg swelling.
• Increased blood potassium levels. This is a serious side effect, so people who are taking ACE inhibitors should have regular blood tests for potassium levels. Signs of increased potassium levels in the blood: confusion, irregular heartbeats, nervousness, numbness or tingling of the hands, feet or lips, shortness of breath, weakness and heaviness in the legs.
• Severe vomiting or diarrhea.

Enam.

Enam belongs to drugs of ACE inhibitors.The mechanism of action of enam is that it inhibits the conversion of renin into angiotensin, a biologically active substance that leads to vasoconstriction and an increase in blood pressure.

Indications for the use of enam.

Enam is used for both hypertension and heart failure. It dilates blood vessels and, by lowering pressure, reduces blood flow to the heart. As a result, the load on the heart is also reduced. Enam can be used alone or in combination with other drugs to lower high blood pressure.It is also used immediately after myocardial infarction to reduce damage to the heart muscle. In addition, enam is used to prevent kidney pathology in diabetes mellitus.

Application of enam during pregnancy and lactation.

Enam is not recommended to be taken during pregnancy as it may harm the fetus.

The drug is not recommended for women who are breastfeeding.

Precautions before taking enam.

Before taking enam, tell your doctor if you have any of the following conditions:

• Allergy to any drugs.
• Pathology of the kidneys, liver.
• Blood vessel pathology.
• Hyperkalemia.
• Stroke.
• Diabetes mellitus.
• Dehydration.

It is not recommended to drink alcohol while taking Enam.

Due to the fact that the drug may cause dizziness, it is recommended to be careful when driving a car and other physical activity.

Rules for the reception of enam.

Enam is prescribed in doses from 2.5 to 40 mg 1-2 times a day. The dose of the drug depends on the degree of hypertension.

Enam can also be prescribed during a hypertensive crisis, in which case the pill is placed under the tongue and dissolves.

Side effects of enam.

In general, enam is well tolerated and the side effects from it are minor and temporary. Almost all ACE inhibitors, including enam, have a dry cough as a side effect.After stopping the drug, the cough stops.

Other possible side effects of enam include:

• Headache.
• Dizziness.
• Sore throat.
• Chest pain.
• Abdominal pain.
• Numbness of fingers and toes.
• Nausea and vomiting.
• Diarrhea.
• Loss of appetite.
• Fatigue.
• Skin rash.

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