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Medicine wellbutrin: Drug Database | Medication Decision Support

by alexxlab

WELLBUTRIN XL® for HCP’s, Clinical Experience in MDD & SAD

INDICATION

WELLBUTRIN XL® (bupropion hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase the risk of suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. People who have (or have a family history of) bipolar illness or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in patients under the age of 18.

Call your healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

Although WELLBUTRIN XL is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking.

Some people have had serious side effects while taking bupropion to help them quit smoking, including:

New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, or suicidal thoughts or actions. Some people had these symptoms when they began taking bupropion, and others developed them after several weeks of treatment, or after stopping bupropion. These symptoms happened more often in people who had a history of mental health problems before taking bupropion than in people without a history of mental health problems.

Stop taking WELLBUTRIN XL and call your healthcare provider right away if you, your family, or caregiver notice any of these symptoms. Work with your healthcare provider to decide whether you should continue to take WELLBUTRIN XL. In many people, these symptoms went away after stopping WELLBUTRIN XL, but in some people, symptoms continued after stopping WELLBUTRIN XL. It is important for you to follow-up with your healthcare provider until your symptoms go away.

Before taking WELLBUTRIN XL, tell your healthcare provider if you have ever had depression or other mental health problems. You should also tell your healthcare provider about any symptoms you had during other times you tried to quit smoking, with or without bupropion.

What Other Important Information Should I Know About WELLBUTRIN XL?

  • Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and call your healthcare provider right away.
  • High blood pressure (hypertension): Some people get high blood pressure that can be severe while taking WELLBUTRIN XL.
  • Manic episodes: Some people may have periods of mania while taking WELLBUTRIN XL. If you have any of the following symptoms of mania, call your healthcare provider:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • talking more or faster than usual
  • Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking WELLBUTRIN XL, including delusions (e.g., believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or feeling confused. If this happens to you, call your healthcare provider.
  • Visual problems: Some people are at risk of glaucoma which can present as: eye pain, changes in vision, or swelling and redness around the eye if they take WELLBUTRIN XL. You should see an eye doctor to determine whether you are at risk prior to starting therapy.
  • Severe allergic reactions: Some patients have severe allergic reactions to WELLBUTRIN XL. Stop taking WELLBUTRIN XL and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take WELLBUTRIN XL if you:

  • have or had a seizure disorder or epilepsy
  • have or had an eating disorder such as anorexia nervosa or bulimia
  • are taking any other medicines that contain bupropion, including WELLBUTRIN or WELLBUTRIN SR, APLENZIN®, ZYBAN, or FORFIVO XL. Bupropion is the same active ingredient that is in WELLBUTRIN XL
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines, and you stop using them all of a sudden
  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid
    • do not take an MAOI within 2 weeks of stopping WELLBUTRIN XL unless directed to do so by your healthcare provider
    • do not start WELLBUTRIN XL if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider
  • are allergic to the active ingredient in WELLBUTRIN XL, bupropion, or to any of the inactive ingredients

Although WELLBUTRIN XL is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking. Before taking WELLBUTRIN XL, tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental health problems or any symptoms you had during other times you tried to quit smoking with or without bupropion. Also, tell your healthcare provider about your other medical conditions, including if you:

  • have liver problems, especially cirrhosis of the liver
  • have kidney problems
  • have, or have had, an eating disorder such as anorexia nervosa or bulimia
  • have had a head injury
  • have had a seizure (convulsion, fit)
  • have a tumor in your nervous system (brain or spine)
  • have had a heart attack, heart problems, or high blood pressure
  • are a diabetic taking insulin or other medicines to control your blood sugar
  • drink alcohol
  • abuse prescription medicines or street drugs
  • are pregnant or plan to become pregnant. Talk to your healthcare provider about the risk to your unborn baby if you take WELLBUTRIN XL during pregnancy, and about registering with the National Pregnancy Registry by calling 1-844-405-6185
  • are breastfeeding. WELLBUTRIN XL passes into your milk in small amounts

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are using WELLBUTRIN XL.

The most common side effects of WELLBUTRIN XL include: trouble sleeping, stuffy nose, dry mouth, dizziness, feeling anxious, nausea, constipation, and joint aches.

Click here to read the Medication Guide carefully before you start using WELLBUTRIN XL. If you have any questions about WELLBUTRIN XL, ask your healthcare provider or pharmacist.

Click here for full Prescribing Information, including Medication Guide and Boxed Warning regarding suicidal thoughts and actions.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also contact Bausch Health Customer Service at 1-800-321-4576.

WELLBUTRIN XL®, HCP Information on Patient Savings Program

INDICATION

WELLBUTRIN XL® (bupropion hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase the risk of suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. People who have (or have a family history of) bipolar illness or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in patients under the age of 18.

Call your healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

Although WELLBUTRIN XL is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking.

Some people have had serious side effects while taking bupropion to help them quit smoking, including:

New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, or suicidal thoughts or actions. Some people had these symptoms when they began taking bupropion, and others developed them after several weeks of treatment, or after stopping bupropion. These symptoms happened more often in people who had a history of mental health problems before taking bupropion than in people without a history of mental health problems.

Stop taking WELLBUTRIN XL and call your healthcare provider right away if you, your family, or caregiver notice any of these symptoms. Work with your healthcare provider to decide whether you should continue to take WELLBUTRIN XL. In many people, these symptoms went away after stopping WELLBUTRIN XL, but in some people, symptoms continued after stopping WELLBUTRIN XL. It is important for you to follow-up with your healthcare provider until your symptoms go away.

Before taking WELLBUTRIN XL, tell your healthcare provider if you have ever had depression or other mental health problems. You should also tell your healthcare provider about any symptoms you had during other times you tried to quit smoking, with or without bupropion.

What Other Important Information Should I Know About WELLBUTRIN XL?

  • Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and call your healthcare provider right away.
  • High blood pressure (hypertension): Some people get high blood pressure that can be severe while taking WELLBUTRIN XL.
  • Manic episodes: Some people may have periods of mania while taking WELLBUTRIN XL. If you have any of the following symptoms of mania, call your healthcare provider:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • talking more or faster than usual
  • Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking WELLBUTRIN XL, including delusions (e.g., believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or feeling confused. If this happens to you, call your healthcare provider.
  • Visual problems: Some people are at risk of glaucoma which can present as: eye pain, changes in vision, or swelling and redness around the eye if they take WELLBUTRIN XL. You should see an eye doctor to determine whether you are at risk prior to starting therapy.
  • Severe allergic reactions: Some patients have severe allergic reactions to WELLBUTRIN XL. Stop taking WELLBUTRIN XL and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take WELLBUTRIN XL if you:

  • have or had a seizure disorder or epilepsy
  • have or had an eating disorder such as anorexia nervosa or bulimia
  • are taking any other medicines that contain bupropion, including WELLBUTRIN or WELLBUTRIN SR, APLENZIN®, ZYBAN, or FORFIVO XL. Bupropion is the same active ingredient that is in WELLBUTRIN XL
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines, and you stop using them all of a sudden
  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid
    • do not take an MAOI within 2 weeks of stopping WELLBUTRIN XL unless directed to do so by your healthcare provider
    • do not start WELLBUTRIN XL if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider
  • are allergic to the active ingredient in WELLBUTRIN XL, bupropion, or to any of the inactive ingredients

Although WELLBUTRIN XL is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking. Before taking WELLBUTRIN XL, tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental health problems or any symptoms you had during other times you tried to quit smoking with or without bupropion. Also, tell your healthcare provider about your other medical conditions, including if you:

  • have liver problems, especially cirrhosis of the liver
  • have kidney problems
  • have, or have had, an eating disorder such as anorexia nervosa or bulimia
  • have had a head injury
  • have had a seizure (convulsion, fit)
  • have a tumor in your nervous system (brain or spine)
  • have had a heart attack, heart problems, or high blood pressure
  • are a diabetic taking insulin or other medicines to control your blood sugar
  • drink alcohol
  • abuse prescription medicines or street drugs
  • are pregnant or plan to become pregnant. Talk to your healthcare provider about the risk to your unborn baby if you take WELLBUTRIN XL during pregnancy, and about registering with the National Pregnancy Registry by calling 1-844-405-6185
  • are breastfeeding. WELLBUTRIN XL passes into your milk in small amounts

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are using WELLBUTRIN XL.

The most common side effects of WELLBUTRIN XL include: trouble sleeping, stuffy nose, dry mouth, dizziness, feeling anxious, nausea, constipation, and joint aches.

Click here to read the Medication Guide carefully before you start using WELLBUTRIN XL. If you have any questions about WELLBUTRIN XL, ask your healthcare provider or pharmacist.

Click here for full Prescribing Information, including Medication Guide and Boxed Warning regarding suicidal thoughts and actions.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also contact Bausch Health Customer Service at 1-800-321-4576.

90,000 For the first time in history, an AI-developed cure for a deadly disease is being tested on humans. It was created by a native of the USSR

Digitalization
Technique

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    Idiopathic pulmonary
    fibrosis was created entirely by artificial intelligence. Now it’s already gone
    Phase 2 placebo trials.

    First ever AI drug

    Clinical trials started
    trials of the first drug entirely developed by artificial intelligence (AI),
    reports CNBC. INSO18_055 is indicated for the treatment of idiopathic pulmonary fibrosis (IPF),
    a fairly common chronic disease, as a result of which the pulmonary
    tissue is covered with scars.

    USA only from this
    diseases now affect up to 100 thousand people. Without treatment, it can
    take the patient to the grave within 2-5 years.

    Applied to
    To date, drugs are predominantly aimed at slowing down the development of
    diseases, but often give extremely unpleasant side effects.

    INSO18_055 was created with the aim of
    to overcome the main problems of modern drugs for IPF.

    Direct
    the manufacturer of the drug is the biotechnology startup Insilico Medicine, whose headquarters
    is located in Hong Kong. Its founder and CEO Alexander
    Zhavoronkov     was born in 1979 in Riga (then the USSR), studied in Canada and the USA,
    defended his Ph.D. thesis in Moscow at the Moscow State University. M. V. Lomonosov.

    Photo: en.freepik

    First AI drug in clinical trials

    “This is the first ever
    generative AI drug that has reached the second phase of clinical
    human trials, says Zhavoronkov.
    “There are already other drugs developed by AI, but ours is the first where AI
    determined both the key object of influence and the structure of the drug.

    Mobile office for medical representatives: SberCRM helped automate the business processes of a pharmaceutical company

    Business

    According to Zhavoronkov,
    when the company was created, its founders immediately focused on algorithms
    — on the development of technology capable of independently detecting and
    design new molecules.

    “In those days I imagine
    could not imagine that our AI drugs would be undergoing clinical trials on
    patients. But we realized that in order to adequately test our AI platform
    it is necessary not only to create new drugs with a new mechanism of action, but also
    bring them to clinical trial. Only then can we say that our
    the technology works,” said Zhavoronkov.

    Phase 2

    Currently
    the drug is being double-blind, randomized, placebo-controlled
    study involving 60 patients in 40 different US clinics and
    China. If this phase is successful, the test will continue with more
    people involved. The current study will take about 12 weeks, and its results
    planned to be delivered next year.

    How to optimize the internal logistics of the enterprise?

    BY

    “Using AI for
    creating new drugs is one of the main arguments in favor of continuing its
    developments against the backdrop of growing fears around the world, says Alexey Vodyasov , technical director
    SEQ company. —
    Apparently, AI will really be able to advance medicine far ahead.
    The problem is that it is capable of creating new ones with the same efficiency.
    poisonous substances and weapons. AI is a potential weapon in its own right.
    needs tight control. As for the efforts to create with it
    new means of saving lives, this is to be welcomed.”

    Two more drugs,
    created by Insilico Medicine
    with the participation of AI, are now undergoing clinical trials: a cure for COVID-19 (in the first phase) and
    drug against oncological diseases, which will have to help in
    treatment of solid tumors. They were, however, created
    AI only partially.

    • Choose the best virtual VPS/VDS server on the Market.CNews IT marketplace

    Roman Georgiev

    Therapist Sukhova explained what happens if you don’t take pills with water. Find out why water and milk are good for this purpose, but fruit juice is not.

    July 5, 20231

    Source:
    iStockphoto

    When a doctor prescribes medicine, we usually don’t think about the requirement to take it with water. What happens if you ignore this recommendation? What kind of water is best to drink drugs? These questions are answered by therapist Vera Sukhova.

    Most drugs should be taken with water. This is a neutral substance that serves as an excellent medium for chemical reactions between compounds, which will help the drug to be better absorbed.

    Will something terrible happen if you don’t take a pill with anything? At best, the drug will not dissolve well in the stomach and its action will simply be slower. But at worst, the pill can get stuck while passing through the esophagus.

    Read also

    How should I ideally take pills? The most optimal drink is purified warm water (or water at room temperature) without gas. Cold water interferes with normal absorption and can cause eating disorders: diarrhea, nausea, vomiting, and so on. Hot – can burn the esophagus and dissolve the tablet prematurely. The recommended volume of liquid is from 100 ml.

    Read also

    The use of milk is acceptable, it envelops the gastric mucosa and facilitates the absorption of the drug. This is especially important with the constant use of non-steroidal anti-inflammatory drugs and certain hormones.

    Mineral water increases the risk of a chemical reaction with the active substance contained in the preparation. Therefore, mineral water, especially carbonated water, is not suitable for drinking tablets.