What are the primary uses of Metaxalone 400mg. How should Metaxalone be taken for optimal results. What are the potential side effects and interactions of Metaxalone. How does Metaxalone work as a muscle relaxant. What precautions should be taken when using Metaxalone.

Understanding Metaxalone: A Powerful Muscle Relaxant

Metaxalone, commonly prescribed in 400mg doses, is a potent muscle relaxant used to alleviate discomfort associated with acute musculoskeletal conditions. This medication works by affecting the central nervous system to produce muscle relaxation, providing relief from pain and stiffness.

How does Metaxalone differ from other muscle relaxants? Unlike some alternatives, Metaxalone doesn’t directly act on the muscles or nerves. Instead, it works within the brain and spinal cord to reduce pain sensations and promote relaxation. This unique mechanism of action makes it an effective choice for many patients suffering from muscle-related discomfort.

Key Benefits of Metaxalone

• Effective pain relief for acute musculoskeletal conditions
• Promotes muscle relaxation without directly affecting muscle tissue
• Can be used in combination with physical therapy and rest for optimal results
• Generally well-tolerated with fewer side effects compared to some other muscle relaxants

Proper Usage and Dosage Guidelines for Metaxalone 400mg

Adhering to proper dosage instructions is crucial for maximizing the benefits of Metaxalone while minimizing potential risks. The typical recommended dose is 800mg (two 400mg tablets) taken three to four times daily. However, dosage may vary based on individual patient needs and medical conditions.

Should Metaxalone be taken with food? It’s generally recommended to take Metaxalone with food to enhance its absorption and potentially reduce the risk of gastrointestinal side effects. Some studies suggest that taking it with a high-fat meal can significantly increase its bioavailability.

Important Dosage Considerations

1. Always follow your healthcare provider’s instructions
2. Do not exceed the prescribed dose
3. Take with food for optimal absorption
4. If you miss a dose, take it as soon as you remember, unless it’s close to the next scheduled dose
5. Avoid doubling up on doses to make up for a missed one

Potential Side Effects and Precautions of Metaxalone

While Metaxalone is generally well-tolerated, it’s essential to be aware of potential side effects. Common side effects may include drowsiness, dizziness, headache, and nausea. In rare cases, more severe side effects can occur.

Can Metaxalone cause allergic reactions? Although rare, some individuals may experience allergic reactions to Metaxalone. Symptoms of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

Less Common but Serious Side Effects

• Severe dizziness or fainting
• Unusual weakness or fatigue
• Yellowing of the eyes or skin (jaundice)
• Dark urine or pale stools
• Persistent nausea or vomiting

If you experience any of these serious side effects, contact your healthcare provider immediately.

Drug Interactions and Contraindications

Metaxalone can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking.

Is it safe to consume alcohol while taking Metaxalone? Combining Metaxalone with alcohol can intensify its sedative effects, leading to increased drowsiness and impaired coordination. It’s strongly advised to avoid alcohol consumption while taking this medication.

Notable Drug Interactions

• MAO inhibitors (e.g., isocarboxazid, phenelzine)
• Certain antidepressants (e.g., fluoxetine, paroxetine)
• Opioid pain medications
• Other central nervous system depressants
• Some antihistamines

Always consult with your healthcare provider or pharmacist before starting any new medication or supplement while taking Metaxalone.

Metaxalone in Pregnancy and Breastfeeding

The safety of Metaxalone during pregnancy and breastfeeding has not been thoroughly established. Limited data is available on its effects on fetal development or its presence in breast milk.

Can Metaxalone be used during pregnancy? The use of Metaxalone during pregnancy should be carefully considered and only under the guidance of a healthcare provider. The potential benefits must be weighed against possible risks to the developing fetus.

Considerations for Pregnant and Breastfeeding Women

• Inform your healthcare provider if you are pregnant or planning to become pregnant
• Discuss the potential risks and benefits of Metaxalone use during pregnancy
• If breastfeeding, consult your doctor before taking Metaxalone
• Consider alternative treatments if advised by your healthcare provider

Long-term Use and Potential for Dependence

While Metaxalone is not considered habit-forming in the same way as some other medications, long-term use should be monitored closely by a healthcare provider. Prolonged use may lead to tolerance, where higher doses are needed to achieve the same effect.

Does Metaxalone cause withdrawal symptoms? Unlike some other muscle relaxants, Metaxalone is not associated with significant withdrawal symptoms when discontinued. However, abrupt discontinuation after long-term use may result in a return of muscle pain or spasms.

Guidelines for Long-term Use

1. Regular follow-ups with your healthcare provider
2. Periodic reassessment of the need for continued use
3. Gradual tapering of the dose if discontinuation is recommended
4. Exploration of alternative treatments or therapies
5. Monitoring for any signs of dependence or misuse

Metaxalone and Its Impact on Daily Activities

As a muscle relaxant with potential sedative effects, Metaxalone can impact an individual’s ability to perform certain daily activities. It’s crucial to understand these effects to ensure safety and optimal functioning while taking the medication.

How does Metaxalone affect driving ability? Metaxalone can cause drowsiness and dizziness, which may impair your ability to drive or operate machinery. It’s advisable to avoid these activities until you know how the medication affects you personally.

Precautions for Daily Activities

• Avoid driving or operating heavy machinery until you know how Metaxalone affects you
• Be cautious when performing tasks that require alertness
• Avoid alcohol and other substances that can enhance drowsiness
• Plan activities around your dosing schedule if possible
• Inform your employer if your job involves potentially dangerous tasks

Comparing Metaxalone to Other Muscle Relaxants

Metaxalone is one of several muscle relaxants available for treating musculoskeletal conditions. Understanding how it compares to other options can help patients and healthcare providers make informed decisions about treatment.

What makes Metaxalone unique among muscle relaxants? Metaxalone’s mechanism of action, which focuses on the central nervous system rather than directly on muscle tissue, sets it apart from some other muscle relaxants. This can result in fewer peripheral side effects for some patients.

Comparison with Common Muscle Relaxants

Metaxalone in Combination Therapies

While Metaxalone can be effective on its own, it’s often used as part of a comprehensive treatment plan for musculoskeletal conditions. Combining Metaxalone with other therapies can enhance its effectiveness and promote faster recovery.

How does physical therapy complement Metaxalone treatment? Physical therapy can help strengthen muscles, improve flexibility, and correct posture issues that may contribute to muscle pain. When combined with Metaxalone, physical therapy can lead to more significant improvements in pain relief and function.

Common Combination Therapies

• Physical therapy exercises
• Heat or cold therapy
• Massage therapy
• Non-steroidal anti-inflammatory drugs (NSAIDs)
• Lifestyle modifications (e.g., ergonomic adjustments, stress reduction techniques)

It’s important to note that any combination therapy should be discussed with and approved by your healthcare provider to ensure safety and effectiveness.

Managing Potential Drug Interactions with Metaxalone

As with many medications, Metaxalone can interact with other drugs, potentially altering their effectiveness or increasing the risk of side effects. Understanding and managing these interactions is crucial for safe and effective treatment.

Why is it important to inform healthcare providers about all medications and supplements? Some interactions can be serious or even life-threatening. By providing a complete list of all substances you’re taking, your healthcare provider can assess potential risks and adjust your treatment plan accordingly.

Steps to Manage Drug Interactions

1. Maintain an up-to-date list of all medications, supplements, and herbal products you’re taking
2. Inform all healthcare providers about your current medications, including Metaxalone
3. Ask about potential interactions before starting any new medication or supplement
4. Be aware of the signs of potential drug interactions and report any unusual symptoms to your healthcare provider
5. Consider using a single pharmacy for all prescriptions to help track potential interactions

Metaxalone and Its Impact on Laboratory Tests

Metaxalone can potentially interfere with certain laboratory tests, leading to inaccurate results. This interference is particularly notable with urine glucose tests, where Metaxalone may cause false-positive results.

How can patients ensure accurate test results while taking Metaxalone? Informing laboratory personnel and healthcare providers about your Metaxalone use is crucial. This allows them to interpret results accurately or choose alternative testing methods if necessary.

Laboratory Tests Potentially Affected by Metaxalone

• Urine glucose tests
• Certain liver function tests
• Some drug screening tests

Always inform healthcare providers and laboratory personnel about your Metaxalone use before undergoing any tests to ensure accurate interpretation of results.

Storage and Disposal of Metaxalone

Proper storage and disposal of Metaxalone are essential for maintaining its effectiveness and preventing accidental ingestion or misuse. Following guidelines for medication storage and disposal helps ensure safety and environmental protection.

What are the best practices for storing Metaxalone? Store Metaxalone at room temperature, away from moisture and direct light. Keep it in its original container, tightly closed, and out of reach of children and pets.

Storage and Disposal Guidelines

• Store at room temperature (20-25°C or 68-77°F)
• Keep away from heat, moisture, and direct light
• Do not store in the bathroom
• Keep out of reach of children and pets
• Do not use expired medication
• Dispose of unused medication through proper channels (e.g., drug take-back programs)

Recognizing and Managing Metaxalone Overdose

While Metaxalone is generally safe when used as prescribed, overdose is possible and can be dangerous. Recognizing the signs of overdose and knowing how to respond can be life-saving.

What are the symptoms of Metaxalone overdose? Symptoms may include severe drowsiness, confusion, slowed breathing, loss of consciousness, and in severe cases, coma. If you suspect an overdose, seek emergency medical attention immediately.

Steps to Take in Case of Suspected Overdose

1. Call emergency services or poison control immediately
2. Provide information about the amount ingested and time of ingestion if known
3. Do not induce vomiting unless instructed by a medical professional
4. If the person is unconscious, turn them on their side to prevent choking
5. Have the medication container or label available for reference

Metaxalone’s Role in Managing Chronic Pain Conditions

While Metaxalone is primarily prescribed for acute musculoskeletal conditions, its use in managing chronic pain conditions is an area of ongoing research and clinical interest. Understanding its potential role in long-term pain management can help patients and healthcare providers make informed decisions about treatment options.

Can Metaxalone be effective for chronic pain conditions? While primarily used for short-term relief, some patients with chronic musculoskeletal pain may benefit from carefully monitored, intermittent use of Metaxalone as part of a comprehensive pain management plan.

Considerations for Chronic Pain Management

• Regular assessment of efficacy and side effects
• Combination with other pain management strategies (e.g., physical therapy, cognitive behavioral therapy)
• Monitoring for potential tolerance or dependence
• Exploration of alternative or complementary treatments
• Periodic medication holidays to assess ongoing need and effectiveness

It’s crucial to work closely with a healthcare provider to develop a personalized approach to chronic pain management that may or may not include Metaxalone, depending on individual circumstances and response to treatment.

Metaxalone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product (dextromethorphan/quinidine), levodopa, maprotiline, methyldopa, metoclopramide, certain opioid pain relievers (such as fentanyl, meperidine, methadone, tapentadol), certain drugs for Parkinson’s disease (such as entacapone, tolcapone), certain supplements (such as tryptophan, tyramine), tetrabenazine, tricyclic antidepressants (such as amitriptyline, doxepin), valbenazine.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including mirtazapine, SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tramadol, certain “triptans” used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Some products can interact with metaxalone if you take them together, or even if you take them weeks before or after taking metaxalone. Tell your doctor or pharmacist if you take anything in the list of products that may interact with this drug, or any of the products that increase serotonin, within 2 weeks before or after taking metaxalone. Also tell them if you have taken fluoxetine within 5 weeks before starting metaxalone. Ask your doctor how much time to wait between starting or stopping any of these drugs and starting metaxalone.

Taking other MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using metaxalone, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with metaxalone, including herbal products (such as ephedra/ma huang), nasal decongestants (such as phenylephrine, pseudoephedrine), and stimulants (such as amphetamines, ephedrine, epinephrine, phenylalanine). Metaxalone should not be used with any of these medications. Talk to your doctor or pharmacist for more details.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), other muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain lab tests (such as certain urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Metaxalone interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Metaxalone: MedlinePlus Drug Information

pronounced as (me tax’ a lone)

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Metaxalone, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

Metaxalone comes as a tablet to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metaxalone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metaxalone,

• tell your doctor and pharmacist if you are allergic to metaxalone, any other medications, or any of the ingredients in metaxalone tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking metaxolone. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had kidney disease, liver disease, seizures, or a blood disorder.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking metaxalone, call your doctor immediately.
• talk to your doctor about the risks and benefits of taking metaxalone if you are 65 years of age or older. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how metaxalone affects you.
• remember that alcohol can add to the drowsiness caused by this drug.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Metaxalone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• drowsiness
• dizziness
• headache
• nervousness

If you experience any of the following symptoms, call your doctor immediately:

• agitation, hallucinations, coma
• fast heart rate, high body temperature
• muscle twitching, loss of muscle control
• nausea, vomiting, diarrhea
• severe skin rash
• difficulty breathing
• yellowing of the skin or eyes
• unusual bruising or bleeding
• unusual tiredness or weakness
• seizures

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo. gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Skelaxin^®

Last Revised – 07/15/2022

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instructions for use, dosage, composition, analogues, side effects / Pillintrip

and PATIENT INFORMATION ).

Carcinogenesis, mutagenesis, impaired fertility

The carcinogenic potential of metaxalone has not been determined.

Pregnancy

Reproduction studies in rats showed no evidence of impaired fertility or fetal harm due to metaxalone. Post-marketing experience has not shown any evidence of fetal injury, but such experience cannot rule out the possibility of rare or subtle injury to the human fetus. The safe use of metaxalone has not been demonstrated in relation to possible adverse effects on fetal development. Therefore, metaxalone tablets should not be used in women who are or may be pregnant, especially during early pregnancy, unless the physician considers that the potential benefits outweigh the potential hazards.

Nursing mothers

It is not known if this drug is excreted in breast milk. As a general rule, caution should not be exercised when taking medications, as many medications are excreted in breast milk.

Pediatric use

Safety and efficacy in children over 12 years of age have not been established.

Overdose and Contraindications

Intentional or accidental overdose deaths have occurred with metaxalone, especially when combined with antidepressants, and this class of drug has been reported in combination with alcohol.

Serotonin syndrome has been reported when metaxalone was used at doses above the recommended dose layers (see WARNINGS ).

When determining LD ₅₀ progressive sedation, hypnosis and finally respiratory failure were found in rats and mice with increasing dosage. No LD can be found in dogs ₅₀ is determined because higher doses were emetic after 15-30 minutes.

Treatment

Gastric lavage and supportive care. It is recommended that you consult with your regional gift management center.

PRICE

Hypersensitivity to components of this product is known.

Known tendency to drug-induced, hemolytic or other anemia.

Significantly impaired renal or hepatic function.

Clinical pharmacology

CLINICAL PHARMACOLOGY

Mechanism of action

The mechanism of action of metaxalone in humans has not been established, but it can be attributed to a general depression of the central nervous system.

Metaxalone has no direct effect on the contractile mechanism of the striated muscle, motor end plate or nerve fiber.

Pharmacokinetics

The pharmacokinetics of metaxalone was studied in healthy adult volunteers after a single dose of metaxalone in sober and well-fed conditions at doses ranging from 400 to 800 mg.

Absorption

Peak plasma concentrations of metaxalone occur approximately 3 hours after an oral dose of 400 mg under sober conditions. The logarithmic concentrations of metaxalone then decrease with a finite half-life of 9.0 ± 4.8 hours. Doubling the dose of Metaxalone from 400 mg to 800 mg results in an approximately proportional increase in Metaxalone exposure as evidenced by peak plasma concentrations (Cmax) and area under the curve (AUC). Dose proportionality at doses above 800 mg has not been studied. The absolute bioavailability of metaxalone is not known.

Pharmacokinetic parameters of single dose metaxalone in two groups of healthy volunteers are shown in Table 1.

Table 1: Mean (% CV) pharmacokinetic parameters of Metaxalone

Dose (mg)	Cmax (ng/ml)	Tmax (h)	AUC∞ (ng & ml; h/ml)	t½ (h)	CL / F ( L / h)
400 1	983 (53)	3. 3 (35)	7479 (51)	9, 0 (53)	68 (50)
800 2	1816 (43)	3.0 (39)	15044 (46)	8.0 (58)	66 (51)
1 Subjects received 1x400mg tablet sober (N = 42) 2 Subjects received 2x400mg tablets sober conditions (N = 59)

Food Effects

A randomized, bi-directional, crossover study was conducted in 42 healthy volunteers (31 males, 11 females) who administered a Metaxalone 400 mg tablet while sober and after a standard high-fat breakfast. Subjects ranged from 18 to 48 years (mean age = 23.5 ± 5.7 years). Compared to sober states, the presence of a high-fat meal increased by 177.5% during drug C administration and increased AUC (AUC0-t, AUC∞) by 123.5% and 115.4%, respectively. Time to peak concentration (Tmax) was also delayed (4.3 hours vs. 3.3 hours) and the terminal half-life was reduced (2. 4 hours vs. 9.0 hours) under feeding conditions compared with fasting.

In a second study with a similar effect, healthy volunteers (N = 59, 37 males, 22 females) were given two tablets of metaxalone 400 mg (800 mg) aged 18-50 years (mean age = 25). 6 ± 8.7 years). Compared to sober states, the presence of a high-fat meal increased by 193.6% during drug C administration and increased AUC (AUC0-t, AUC, ∞) by 146.4% and 142.2%, respectively. Time to Peak concentration (Tmax) was also delayed (4.9h versus 3.0 h), and the terminal half-life was shortened (4.2 h compared to 8.0 h) under fed versus fasting conditions. Similar nutritional effects were observed in the aforementioned study when a Metaxalone tablet was administered instead of two 400 mg Metaxalone tablets. An increase in metaxalone exposure, which coincides with a decrease in half-life, may be due to more complete absorption of metaxalone in the presence of a high-fat meal (Figure 1).

Figure 1: Mean (SD) concentrations of metaxalone after a dose of 800 mg under fasting and feeding conditions

Distribution, metabolism and elimination

Although plasma protein binding and absolute bioavailability of metaxalone are unknown, the apparent volume of distribution (V/F 800 L) and lipophilia (log P = 2. 42) of metaxalone indicate that the drug is mainly distributed in tissues. Metaxalone is metabolized in the liver and excreted in the urine as unidentified metabolites. Hepatic cytochrome P450 enzymes play a role in the metabolism of metaxalone. In particular, CYP1A2, CYP2D6, CYP2E1 and CYP3A4 and to a lesser extent CYP2C8, CYP2C9and CYP2C19 metabolize metaxalone.

Metaxalone does not significantly inhibit major CYP enzymes such as CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4. Metaxalone does not cause significant induction of important CYP enzymes such as CYP1A2, CYP2B6 and CYP3A4 in vitro .

Pharmacokinetics in special populations

Age

The effect of age on the pharmacokinetics of metaxalone was determined after a single administration of two 400 mg (800 mg) tablets under fasting and feeding conditions. The results were evaluated separately, as well as in combination with the results of three other studies. Using the combined data, the results show that the pharmacokinetics of metaxalone under sober conditions is significantly more dependent on age than under feeding, with bioavailability increasing with age under sober conditions.

The fasting and feeding bioavailability of metaxalone in three groups of healthy volunteers of different ages is shown in Table 2.

Table 2: Mean pharmacokinetic parameters (% CV) feeding

Gender

in which 48 healthy adult subjects (24 men, 24 women) were administered, two tablets of metaxalone 400 mg (800 mg) in sober conditions. The bioavailability of metaxalone was significantly higher in women than in men than Cmax (2115 ng/ml vs 1335 ng/ml) and AUC∞ (17884 ng h/ml vs 10328 ng h/ml). The mean half-life was 11.1 hours for women and 7.6 hours for men. The apparent volume of distribution of metaxalone was approximately 22% higher in men than in women, but the difference was not significant when adjusted for body weight. Similar results were also seen when the previously described combined data set was used in the analysis.

Liver/renal failure

The effect of liver and kidney disease on the pharmacokinetics of metaxalone has not been determined. In the absence of such information, Metaxalone should be used with caution in patients with hepatic and/or renal insufficiency.

Skelaxin (Metaxalone): Uses, Dosage, Side Effects, Interactions, Warning0294 Product Description