What are the key benefits of methylcobalamin. How does it differ from other forms of vitamin B12. Can methylcobalamin effectively treat vitamin B12 deficiency. What are the potential side effects and precautions when taking methylcobalamin supplements.

Understanding Methylcobalamin: A Vital Form of Vitamin B12

Methylcobalamin is a crucial form of vitamin B12 that plays a significant role in maintaining optimal health. As an active form of B12, it is readily used by the body for various essential functions. This article delves into the uses, benefits, and potential side effects of methylcobalamin supplementation.

The Role of Methylcobalamin in Treating Vitamin B12 Deficiency

Methylcobalamin is primarily used to address vitamin B12 deficiency, a condition that can have serious health implications if left untreated. Vitamin B12 is essential for several bodily functions, including:

• Brain and nerve health
• Production of red blood cells
• DNA synthesis
• Energy metabolism

Is methylcobalamin effective in treating vitamin B12 deficiency. Research suggests that methylcobalamin is highly effective in addressing B12 deficiency, particularly because it is an active form of the vitamin that can be readily utilized by the body. This makes it an excellent choice for individuals with absorption issues or those following vegetarian or vegan diets.

Methylcobalamin vs. Other Forms of Vitamin B12

How does methylcobalamin differ from other forms of vitamin B12. Methylcobalamin is one of several forms of vitamin B12, with the most common alternatives being cyanocobalamin and hydroxocobalamin. The key differences include:

• Bioavailability: Methylcobalamin is more bioavailable, meaning it is more easily absorbed and used by the body.
• Conversion: Unlike cyanocobalamin, methylcobalamin does not require conversion in the body, making it more efficient.
• Retention: Studies suggest that methylcobalamin may be retained in the body’s tissues for longer periods compared to other forms.

These factors contribute to methylcobalamin’s popularity as a supplement and its effectiveness in treating B12 deficiency.

Medical Conditions Treated with Methylcobalamin

Beyond addressing vitamin B12 deficiency, methylcobalamin has shown promise in treating various medical conditions. Some of these include:

• Pernicious anemia
• Diabetic neuropathy
• Alzheimer’s disease
• Sleep-wake rhythm disorders
• Chronic fatigue syndrome

How effective is methylcobalamin in treating these conditions. While research is ongoing, many studies have shown promising results, particularly in the areas of neuropathy and cognitive function. However, it’s essential to consult with a healthcare provider before using methylcobalamin for any specific medical condition.

Proper Dosage and Administration of Methylcobalamin

Determining the right dosage of methylcobalamin is crucial for its effectiveness and safety. The appropriate dose can vary depending on factors such as age, health condition, and the severity of B12 deficiency. Common forms of methylcobalamin supplements include:

• Oral tablets or capsules
• Sublingual tablets
• Lozenges
• Injectable solutions

How should methylcobalamin be taken for optimal absorption. For oral supplements, it’s often recommended to take them on an empty stomach or between meals. Sublingual tablets and lozenges should be allowed to dissolve under the tongue for better absorption. Injectable methylcobalamin is typically administered by a healthcare professional.

Recommended Dosages

While specific dosages should be determined by a healthcare provider, general guidelines for methylcobalamin supplementation include:

• For general health maintenance: 500-1000 mcg daily
• For treating B12 deficiency: 1000-5000 mcg daily, or as prescribed
• For specific medical conditions: Dosages may vary and should be determined by a healthcare professional

It’s important to note that these are general guidelines and individual needs may vary.

Potential Side Effects and Precautions of Methylcobalamin

While methylcobalamin is generally considered safe, it’s essential to be aware of potential side effects and take necessary precautions. Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching

Are there any serious side effects associated with methylcobalamin use. While rare, some individuals may experience more severe reactions, such as anaphylaxis or severe allergic reactions. It’s crucial to seek immediate medical attention if you experience symptoms like difficulty breathing, chest pain, or severe swelling.

Precautions and Contraindications

Certain individuals should exercise caution or avoid methylcobalamin supplementation, including:

• Those allergic to vitamin B12 or cobalt
• Individuals with Leber’s disease or other forms of optic nerve damage
• People with low potassium levels
• Pregnant or breastfeeding women (consult with a healthcare provider)

Always inform your healthcare provider about any medical conditions, allergies, or medications you’re taking before starting methylcobalamin supplementation.

Drug Interactions with Methylcobalamin

Methylcobalamin can interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Some notable drug interactions include:

• Chloramphenicol (an antibiotic)
• Colchicine
• Metformin and other oral diabetes medications
• Stomach acid-reducing medications (e.g., omeprazole, lansoprazole)

How do these medications interact with methylcobalamin. Some antibiotics may reduce the absorption of B12, while acid-reducing medications can interfere with its release in the stomach. In the case of metformin, long-term use may lead to B12 deficiency, making supplementation necessary.

It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking to avoid potential interactions.

Methylcobalamin and Special Populations

Certain groups of people may have unique considerations when it comes to methylcobalamin supplementation:

Vegetarians and Vegans

Plant-based diets often lack natural sources of vitamin B12, making supplementation crucial. Methylcobalamin is an excellent choice for vegetarians and vegans due to its bioavailability and the fact that it’s not derived from animal sources.

Older Adults

As we age, our ability to absorb vitamin B12 from food sources may decrease. Methylcobalamin supplementation can help ensure adequate B12 levels in older adults, potentially supporting cognitive function and overall health.

Pregnant and Breastfeeding Women

Adequate B12 levels are crucial during pregnancy and breastfeeding for fetal development and infant health. However, it’s essential to consult with a healthcare provider before starting any supplementation during these periods.

Individuals with Gastrointestinal Disorders

People with conditions that affect nutrient absorption, such as Crohn’s disease or celiac disease, may benefit from methylcobalamin supplementation. The sublingual or injectable forms may be particularly useful in these cases.

How does methylcobalamin supplementation benefit these special populations. By providing a readily absorbable form of B12, methylcobalamin can help prevent deficiency and support overall health in groups at higher risk of B12 deficiency.

The Future of Methylcobalamin Research

As interest in methylcobalamin continues to grow, researchers are exploring its potential benefits in various areas of health and medicine. Some promising areas of research include:

• Neuroprotective effects in neurodegenerative diseases
• Potential role in cancer prevention and treatment
• Impacts on cardiovascular health
• Effects on mood and mental health disorders

What new discoveries might we see in methylcobalamin research? While it’s difficult to predict specific outcomes, ongoing studies may reveal new therapeutic applications for methylcobalamin beyond its current uses. This could potentially lead to more targeted treatments for various health conditions.

As research progresses, it’s essential to stay informed about the latest findings and consult with healthcare professionals to determine the most appropriate use of methylcobalamin for individual health needs.

Methylcobalamin vitamin B12 Uses, Side Effects & Warnings

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Generic name: methylcobalamin (vitamin B12) oral/injection [ METH-il-koe-BAL-a-min ]
Brand names: Methyl B-12, Vitamin B12 Methylcobalamin
Dosage forms: injectable solution (1 mg/mL; 10 mg/mL; 5 mg/mL), oral capsule (2000 mcg), oral lozenge (1 mg; 500 mcg), oral tablet, disintegrating (1 mg), sublingual tablet (5000 mcg)
Drug class: Vitamins

Medically reviewed by Drugs.com on Sep 28, 2022. Written by Cerner Multum.

What is methylcobalamin?

Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Methylcobalamin may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use methylcobalamin if you are allergic to vitamin B12 or cobalt.

Tell your doctor if you have ever had:

• Leber’s disease or other form of optic nerve damage;

• an iron or folic acid deficiency; or

• low levels of potassium in your blood.

Tell your doctor if you are pregnant or breastfeeding.

Do not give methylcobalamin to a child without medical advice.

How should I use methylcobalamin?

Use exactly as directed on the label, or as prescribed by your doctor.

Methylcobalamin oral is taken by mouth.

Methylcobalamin injection is injected into a muscle, usually 1 to 3 times per week. A healthcare provider can teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions.

Do not swallow a lozenge, disintegrating tablet, or sublingual tablet whole. Allow it to dissolve in your mouth without chewing. The sublingual tablet should be placed under your tongue.

Your dose needs may change if you become pregnant, if you breastfeed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.

For more information you may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Dietary Reference Intakes (formerly “Recommended Daily Allowances”) listings for more information.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking methylcobalamin?

Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb methylcobalamin.

Methylcobalamin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of methylcobalamin may include:

• nausea, vomiting, diarrhea;

• loss of appetite; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect methylcobalamin?

Tell your doctor about all your other medicines, especially:

• chloramphenicol;

• colchicine

• antibiotic medicine;

• oral diabetes medicine that contains metformin; or

• medicines that reduce stomach acid, such as cimetidine, omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Zantac, and others.

This list is not complete. Other drugs may affect methylcobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about methylcobalamin

• Check interactions
• Compare alternatives
• Reviews (2)
• Side effects
• Drug class: vitamins

Patient resources

• Patient Information

Professional resources

• Advanced Reading

Related treatment guides

• Dietary Supplementation

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01.

Causes, Symptoms and Treatment Options

Medically reviewed by Drugs.com. Last updated on Mar 24, 2023.

What is Anemia?

Anemia is an abnormally low level of red blood cells.

Red blood cells contain hemoglobin. Hemoglobin is a protein that carries oxygen in the blood.

Red blood cells are produced in the bone marrow and then released into the bloodstream. Normally, they live for 110 to 120 days. Older red blood cells are removed from the blood by the spleen and liver.

Anemia can occur when the bone marrow does not produce enough red blood cells to replace those that have died. Or it can occur if the red blood cells die or are destroyed more quickly than usual.

Reasons for under-production of red blood cells by the bone marrow include:

• iron deficiency caused by inadequate intake, blood loss, or poor absorption from the intestine
• vitamin B₁₂ deficiency from either a strict vegetarian diet or an inability to absorb vitamin B₁₂ (known as pernicious anemia).
• some infections, such as parvovirus infection
• chronic diseases, especially inflammatory diseases such as rheumatoid arthritis
• a side effect of some medications, especially chemotherapy
• a disease of the bone marrow, such as aplastic anemia.

When red blood cells are destroyed too quickly, it’s known as hemolytic anemia. This can happen when:

• red blood cells have an abnormally short life span
• there is something wrong with the red blood cells
• the red blood cells are normal but are destroyed by an external process.

Causes of hemolytic anemia include:

• inherited abnormalities of red blood cells, such as sickle cell anemia
• physical damage to red blood cells, which can occur, for example, during heart bypass surgery or as the blood flows through artificial heart valves
• autoimmune hemolytic anemia, a condition in which the body’s immune system mistakenly destroys its own red blood cells
• an enlarged and overactive spleen (hypersplenism), which can trap circulating red blood cells and destroy them before they are old.

Symptoms

Symptoms vary widely. Mild cases often don’t cause any symptoms. The condition may only be discovered during a routine blood test.

In other people, obvious symptoms of anemia can develop. These include:

• pale skin
• fatigue
• weakness
• dizziness
• lightheadedness
• breathlessness.

Diagnosis

Your doctor will review your medical history. He or she will ask you to describe your symptoms.

During your physical examination, your doctor will look for signs of anemia. These include:

• pale skin and fingernails
• rapid pulse
• heart murmur
• enlarged spleen and liver.

This exam will be followed by blood tests to

• measure the levels of red blood cells
• look at the size and shape of red blood cells
• measure the hemoglobin level
• determine the number of immature red blood cells (the bone marrow may pour out immature blood cells in an effort to make up for the anemia).

Your doctor may also order tests to check for blood in your stool. This can identify whether your anemia is caused by blood loss. Other blood tests check for anemia resulting from a lack of iron or certain vitamins in your diet.

Any other tests you may receive will depend on the suspected cause of your anemia.

Expected duration

How long anemia lasts depends on its cause and how easily it can be corrected. If the reason for the anemia is only inadequate intake of iron or vitamin B₁₂, the anemia will start to correct within days of treatment.

Anemia caused by an inherited illness is a lifelong condition. Its impact on a person’s quality of life and life span can vary greatly, and depends on the specific inherited disorder and its severity. Some people don’t have any symptoms. Others have severe, persistent symptoms.

Prevention

Anemia caused by nutritional deficiency can be prevented by eating a healthy diet or taking a vitamin and mineral supplement when iron or B₁₂ intake might be insufficient.

Most other types of anemia cannot be prevented.

Treatment

Treatment of anemia depends on its severity and cause. Severe anemia may require blood transfusion.

Iron and vitamin B₁₂ deficiency require supplements, which are usually taken by mouth.

Anemia caused by a drug is treated by stopping the drug.

Autoimmune hemolytic anemia is usually treated with drugs called corticosteroids first. Other therapies are added if needed.

Inherited hemolytic anemia may require removal of the spleen (a procedure called splenectomy).

Treatment options

The following list of medications are in some way related to or used in the treatment of this condition.

• epoetin alfa
• Procrit
• Vitamin B6
• Reblozyl
• Epogen

View more treatment options

When to call a professional

Call your doctor promptly if you develop symptoms of anemia. Also call if you notice a yellowish tint to your skin or in the whites of your eyes.

If an inherited form of anemia runs in your family, you may wish to consider genetic testing before you start a family.

Prognosis

The outlook for anemia depends on its cause and severity, as well as the underlying health of the affected person.

Cases that are caused by medications or infections usually go away quickly. Anemia caused by chronic diseases tends to be persistent, but is rarely severe.

People with autoimmune hemolytic anemia usually respond well to treatment.

The outlook for people with inherited anemias depends on the type of inherited illness and its severity.

National Heart, Lung, and Blood Institute (NHLBI)

www.nhlbi.nih.gov/

Learn more about Anemia

Treatment options

• Medications for Anemia
• Medications for Pernicious Anemia

Care guides

• Anemia

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Methylcobalamin/Vitamin B12 2500 mcg 60 tabs

Swanson™ Methylcobalamin/Vitamin B12 2500 mcg

Quantity: 60 tabs.

Swanson™ Methylcobalamin / Vitamin B-12 2500 mcg. is an advanced formula vitamin containing Methylcobalamin which is the active form of vitamin B-12 . Unlike other forms of vitamin B-12, this active form does not need to be converted in the human body before the vitamin can work.

Vitamins B-12:

• Needed for energy production†
• Supports a healthy nervous system †
• Supports healthy brain function †
• Due to their rapid absorption, these vitamins can replace injections

Today’s active lifestyle requires a lot of energy. Every day we are forced to follow a tight schedule, and also have some energy in reserve for what we love to do. Such a pace of life requires a significant amount of energy, and therefore, essential vitamin supplements, such as vitamin B-12. † Maintaining adequate levels of Vitamin B-12 in the body is vital to our health, as Vitamin B-12 is a key vitamin in our body’s enzymatic processes and is essential for the body to function properly to keep the nervous system and brain functioning properly. It helps keep us in good shape. †

Vitamin B12 is known to become less effective with age, so it is recommended that vitamin B12 be taken as a daily supplement by persons over 50 years of age. Vitamin B12 is also recommended for vegetarians, as vitamin B12 is mainly found in animal products.

Features of the formula of these vitamins:

• Rapid absorption by the body
• High Bioavailability Formula Methylcobalamin B-12
• Excellent cherry flavor.

These vitamins use an advanced formula that provides high bioavailability of methylcobalamin , in the form of vitamin B-12. This is an active form B-12 and should not be converted. Therefore, sublingual tablets ensure optimal transfer of vitamin B-12 to the human body. Also, sublingual tablets of vitamin B-12 5000 mcg . can replace injections of of this vitamin.

Other Ingredients: Xylitol, microcrystalline cellulose (plant fiber), croscarmellose sodium, crospovidone, carboxymethylcellulose, citric acid, natural cherry flavor, hydroxypropyl cellulose, hydroxypropyl methylcellulose, calcium palmitate, silica, vegetable juice color [gum rabik, vegetable juice ( Beetroot, Black Carrot, Purple Sweet Potato, Red Cabbage, Red Radish), Maltodextrin, Citric Acid], Stevia Extract (Stevia rebaudiana) (leaf).

Recommended Use:

Take 1-2 tablets per day by placing under the tongue for 30 seconds and then swallowing. USP Verified

This drug has been verified by the United States Pharmacopeia (USP), which is an independent, scientific, non-profit organization that sets strict quality and purity standards for nutritional supplements manufactured and distributed throughout the world.

Our Commitment to Delivering Quality and Value

Since 1969, the Swanson™ brand has been providing high quality nutritional supplements and has earned high praise from customers in that time. Swanson™ vitamins, minerals and supplements are made from carefully selected ingredients sourced from trusted suppliers.

Additives are manufactured in accordance with good manufacturing practices. In addition, many of the ingredients listed above are tested by the United States Pharmacopeia (USP), which is an independent, scientific, non-profit organization that sets strict quality and purity standards for dietary supplements.

Made in USA

OstroVit Vitamin B12 Methylcobalamin 200 tablets

Product form:

tablets

Servings:

800

Pieces:

200

9000 4 Net weight:

38 g

Dominant component:

vitamin B12

EAN -code:

5903933

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OstroVit Vitamin B12 Methylcobalamin 200 tablets

OstroVit Vitamin B12 Methylcobalamin is a dietary supplement from the line of professional vitamins. The product is intended for everyone who wants to supplement their daily diet with vitamin B12.

Vitamin B12 Methylcobalamin

Methylcobalamin is the biologically active form of vitamin B12 recommended for all people who are struggling with the absorption of the non-methyl forms of the vitamin most commonly found in supplements. Methylcobalamin is easily absorbed, stays in tissues longer and does not contain harmful cyanide. Unlike the synthetic form of vitamin B12, it does not convert to methyl directly in the body.

OstroVit Properties Vitamin B12 Methylcobalamin:

• COMPLEX EFFECT – Without enough vitamin B12, our body cannot function properly. Vitamin B12 supports the production of red blood cells and also affects the nervous system, thereby helping you maintain memory and concentration.
• METHYLCOBALAMIN VITAMIN – Methylcobalamin is the best form of vitamin B12 on the market. Compared to the commonly used cyanocobalamin tablets, it is absorbed faster and stays in the body longer. This is a ready-made active substance that does not transform into a simpler form.
• HIGH DOSE – One OstroVit supplement tablet contains 400 micrograms of vitamin B12, equal to four daily doses. With regular use, a package of this supplement lasts for many months.
• VEGAN PRODUCT – If you are a vegetarian, vegan, or rarely eat meat or animal products, vitamin B12 is recommended.

How to use

Take 1 serving (1/4 tablet) per day. This product is intended for adults.

Do not exceed the recommended daily allowance. A food supplement should not be used as a substitute for a varied diet.