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Mobic for: Drug Database | Medical Device Database

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Mobic, Vivlodex (meloxicam) dosing, indications, interactions, adverse effects, and more

  • acebutolol

    Monitor Closely (2)meloxicam decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    acebutolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • aceclofenac

    Monitor Closely (2)aceclofenac and meloxicam both increase anticoagulation. Use Caution/Monitor.

    aceclofenac and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)aceclofenac will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • acemetacin

    Monitor Closely (2)acemetacin and meloxicam both increase anticoagulation. Use Caution/Monitor.

    acemetacin and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)acemetacin will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • acyclovir

    Minor (1)meloxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • agrimony

    Monitor Closely (1)meloxicam and agrimony both increase anticoagulation. Use Caution/Monitor.

  • albuterol

    Monitor Closely (1)meloxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • alendronate

    Minor (1)meloxicam, alendronate.
    Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.

  • alfalfa

    Monitor Closely (1)meloxicam and alfalfa both increase anticoagulation. Use Caution/Monitor.

  • alfuzosin

    Monitor Closely (1)meloxicam decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • aliskiren

    Monitor Closely (1)meloxicam will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.

  • alteplase

    Monitor Closely (1)meloxicam and alteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • American ginseng

    Monitor Closely (1)meloxicam and American ginseng both increase anticoagulation. Use Caution/Monitor.

  • amikacin

    Minor (1)meloxicam increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • amiloride

    Monitor Closely (1)amiloride and meloxicam both increase serum potassium. Modify Therapy/Monitor Closely.

  • aminohippurate sodium

    Minor (1)meloxicam will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • aminolevulinic acid oral

    Serious – Use Alternative (1)aminolevulinic acid oral, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.

  • aminolevulinic acid topical

    Serious – Use Alternative (1)meloxicam, aminolevulinic acid topical.
    Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

  • amiodarone

    Minor (1)amiodarone will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • amobarbital

    Minor (1)amobarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • anamu

    Minor (1)meloxicam and anamu both increase anticoagulation. Minor/Significance Unknown.

  • antithrombin alfa

    Monitor Closely (1)antithrombin alfa and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • antithrombin III

    Monitor Closely (1)antithrombin III and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • apixaban

    Serious – Use Alternative (1)meloxicam and apixaban both increase anticoagulation. Avoid or Use Alternate Drug.

  • arformoterol

    Monitor Closely (1)meloxicam increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • argatroban

    Monitor Closely (1)argatroban and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • asenapine

    Monitor Closely (1)meloxicam decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • aspirin

    Monitor Closely (2)aspirin and meloxicam both increase anticoagulation. Use Caution/Monitor.

    aspirin and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • aspirin rectal

    Monitor Closely (2)aspirin rectal and meloxicam both increase anticoagulation. Use Caution/Monitor.

    aspirin rectal and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin rectal will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • aspirin/citric acid/sodium bicarbonate

    Monitor Closely (2)aspirin/citric acid/sodium bicarbonate and meloxicam both increase anticoagulation. Use Caution/Monitor.

    aspirin/citric acid/sodium bicarbonate and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin/citric acid/sodium bicarbonate will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • atenolol

    Monitor Closely (2)meloxicam decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    atenolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • azficel-T

    Monitor Closely (1)azficel-T, meloxicam. Other (see comment). Use Caution/Monitor.
    Comment: Patients taking anticoagulants may experience increased bruising or bleeding at biopsy and/or injection sites. Concomitant use of anticoagulants is not recommended. Decisions regarding continued use or cessation of anticoagulants should be made by a physician.

  • azilsartan

    Monitor Closely (2)meloxicam, azilsartan.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

  • balsalazide

    Minor (1)meloxicam will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • bemiparin

    Monitor Closely (1)bemiparin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • benazepril

    Monitor Closely (1)benazepril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, benazepril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • bendroflumethiazide

    Monitor Closely (1)meloxicam increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)bendroflumethiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • betaxolol

    Monitor Closely (2)meloxicam decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    betaxolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • betrixaban

    Monitor Closely (1)meloxicam, betrixaban.
    Either increases levels of the other by anticoagulation. Use Caution/Monitor.

  • bimatoprost

    Monitor Closely (1)bimatoprost, meloxicam. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • bisoprolol

    Monitor Closely (2)meloxicam decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    bisoprolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • bivalirudin

    Monitor Closely (1)bivalirudin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • bosentan

    Minor (1)bosentan will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • budesonide

    Monitor Closely (1)meloxicam, budesonide.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • bumetanide

    Monitor Closely (2)meloxicam decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

    meloxicam increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • butabarbital

    Minor (1)butabarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • butalbital

    Minor (1)butalbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • candesartan

    Monitor Closely (3)candesartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    candesartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • captopril

    Monitor Closely (1)captopril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • carbamazepine

    Minor (1)carbamazepine will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • carbenoxolone

    Monitor Closely (1)meloxicam increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carvedilol

    Monitor Closely (2)meloxicam decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    carvedilol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • cefadroxil

    Minor (1)cefadroxil will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefamandole

    Minor (1)cefamandole will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefixime

    Minor (1)cefixime will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefpirome

    Minor (1)cefpirome will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ceftibuten

    Minor (1)ceftibuten will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • celecoxib

    Monitor Closely (2)celecoxib and meloxicam both increase anticoagulation. Use Caution/Monitor.

    celecoxib and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)celecoxib will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • celiprolol

    Monitor Closely (2)meloxicam decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    celiprolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • cephalexin

    Minor (1)cephalexin will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorothiazide

    Monitor Closely (1)meloxicam increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorothiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorpropamide

    Monitor Closely (1)meloxicam increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)meloxicam will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorthalidone

    Monitor Closely (1)meloxicam increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorthalidone will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cholestyramine

    Monitor Closely (1)cholestyramine decreases levels of meloxicam by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

  • choline magnesium trisalicylate

    Monitor Closely (2)meloxicam and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor.

    meloxicam and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of choline magnesium trisalicylate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cinnamon

    Monitor Closely (1)meloxicam and cinnamon both increase anticoagulation. Use Caution/Monitor.

  • ciprofloxacin

    Monitor Closely (1)meloxicam, ciprofloxacin. Other (see comment). Modify Therapy/Monitor Closely.
    Comment: Mechanism: unknown. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • citalopram

    Monitor Closely (1)citalopram, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.

  • clobetasone

    Monitor Closely (1)meloxicam, clobetasone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • clomipramine

    Monitor Closely (1)clomipramine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.

  • clopidogrel

    Monitor Closely (1)clopidogrel, meloxicam.
    Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.

  • colestipol

    Minor (1)colestipol decreases levels of meloxicam by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • cordyceps

    Monitor Closely (1)meloxicam and cordyceps both increase anticoagulation. Use Caution/Monitor.

  • cortisone

    Monitor Closely (1)meloxicam, cortisone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • creatine

    Minor (1)creatine, meloxicam. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.

  • cyclopenthiazide

    Monitor Closely (1)meloxicam increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)cyclopenthiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cyclosporine

    Monitor Closely (1)meloxicam, cyclosporine.
    Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • dabigatran

    Monitor Closely (1)dabigatran and meloxicam both increase anticoagulation. Use Caution/Monitor. Caution is advised, both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.

  • dalteparin

    Monitor Closely (1)dalteparin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • danshen

    Minor (1)meloxicam and danshen both increase anticoagulation. Minor/Significance Unknown.

  • deferasirox

    Monitor Closely (1)deferasirox, meloxicam. Other (see comment). Use Caution/Monitor.
    Comment: Combination may increase GI bleeding, ulceration and irritation. Use with caution.

  • defibrotide

    Monitor Closely (1)defibrotide increases effects of meloxicam by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.

  • deflazacort

    Monitor Closely (1)meloxicam, deflazacort.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • devil’s claw

    Minor (1)meloxicam and devil’s claw both increase anticoagulation. Minor/Significance Unknown.

  • dexamethasone

    Monitor Closely (1)meloxicam, dexamethasone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • diclofenac

    Monitor Closely (2)diclofenac and meloxicam both increase anticoagulation. Use Caution/Monitor.

    diclofenac and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)diclofenac will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • diclofenac topical

    Minor (1)diclofenac topical, meloxicam.
    Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Although low, there is systemic exposure to diclofenac topical; theoretically, concomitant administration with systemic NSAIDS or aspirin may result in increased NSAID adverse effects.

  • diflunisal

    Monitor Closely (2)diflunisal and meloxicam both increase anticoagulation. Use Caution/Monitor.

    diflunisal and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)diflunisal will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • digoxin

    Monitor Closely (1)meloxicam and digoxin both increase serum potassium. Use Caution/Monitor.

  • disulfiram

    Minor (1)disulfiram will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • dobutamine

    Monitor Closely (1)meloxicam increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dong quai

    Monitor Closely (1)meloxicam and dong quai both increase anticoagulation. Use Caution/Monitor.

  • dopexamine

    Monitor Closely (1)meloxicam increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • doxazosin

    Monitor Closely (1)meloxicam decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • drospirenone

    Monitor Closely (1)drospirenone and meloxicam both increase serum potassium. Modify Therapy/Monitor Closely.

  • duloxetine

    Monitor Closely (1)duloxetine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • edoxaban

    Monitor Closely (1)edoxaban, meloxicam.
    Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.

  • efavirenz

    Monitor Closely (1)efavirenz will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • eltrombopag

    Monitor Closely (1)eltrombopag increases levels of meloxicam by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF, meloxicam.
    Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • emtricitabine

    Monitor Closely (1)emtricitabine, meloxicam.
    Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • enalapril

    Monitor Closely (1)enalapril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, enalapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • enoxaparin

    Monitor Closely (1)enoxaparin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • ephedrine

    Monitor Closely (1)meloxicam increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine

    Monitor Closely (1)meloxicam increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine racemic

    Monitor Closely (1)meloxicam increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • eplerenone

    Minor (1)meloxicam decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • epoprostenol

    Monitor Closely (1)meloxicam and epoprostenol both increase anticoagulation. Use Caution/Monitor.

  • eprosartan

    Monitor Closely (3)meloxicam decreases effects of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    eprosartan and meloxicam both increase serum potassium. Use Caution/Monitor.

    eprosartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • escitalopram

    Monitor Closely (1)escitalopram, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • esmolol

    Monitor Closely (2)meloxicam decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    esmolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • ethacrynic acid

    Monitor Closely (1)meloxicam increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • etodolac

    Monitor Closely (2)etodolac and meloxicam both increase anticoagulation. Use Caution/Monitor.

    etodolac and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)etodolac will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • etravirine

    Minor (1)etravirine will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • felbamate

    Minor (1)felbamate will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • fennel

    Monitor Closely (1)meloxicam and fennel both increase anticoagulation. Use Caution/Monitor.

  • fenoprofen

    Monitor Closely (2)fenoprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.

    fenoprofen and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)fenoprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • feverfew

    Monitor Closely (1)meloxicam and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)meloxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

  • fish oil triglycerides

    Monitor Closely (1)fish oil triglycerides will increase the level or effect of meloxicam by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.

  • fluconazole

    Minor (1)fluconazole will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • fludrocortisone

    Monitor Closely (1)meloxicam, fludrocortisone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • fluoxetine

    Monitor Closely (2)fluoxetine will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

    fluoxetine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • flurbiprofen

    Monitor Closely (2)flurbiprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.

    flurbiprofen and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)flurbiprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • fluvoxamine

    Monitor Closely (1)fluvoxamine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding; SSRIs inhib. srotonin uptake by platelets.

  • fondaparinux

    Monitor Closely (1)fondaparinux and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • formoterol

    Monitor Closely (1)meloxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • forskolin

    Monitor Closely (1)meloxicam and forskolin both increase anticoagulation. Use Caution/Monitor.

  • fosinopril

    Monitor Closely (1)fosinopril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, fosinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • furosemide

    Monitor Closely (1)meloxicam increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)meloxicam decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • ganciclovir

    Minor (1)meloxicam will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • garlic

    Monitor Closely (1)meloxicam and garlic both increase anticoagulation. Use Caution/Monitor.

  • gemifloxacin

    Monitor Closely (1)gemifloxacin, meloxicam. Other (see comment). Modify Therapy/Monitor Closely.
    Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • gentamicin

    Monitor Closely (1)meloxicam increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)meloxicam increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • ginger

    Monitor Closely (1)meloxicam and ginger both increase anticoagulation. Use Caution/Monitor.

  • ginkgo biloba

    Monitor Closely (1)meloxicam and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

  • glimepiride

    Monitor Closely (1)meloxicam increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • glipizide

    Monitor Closely (1)meloxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • glyburide

    Monitor Closely (1)meloxicam increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • green tea

    Monitor Closely (1)green tea, meloxicam. Other (see comment). Use Caution/Monitor.
    Comment: Combination may increase risk of bleeding.

  • heparin

    Monitor Closely (1)heparin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • horse chestnut seed

    Monitor Closely (1)meloxicam and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

  • hydralazine

    Monitor Closely (1)meloxicam decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • hydrochlorothiazide

    Monitor Closely (1)meloxicam increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • hydrocortisone

    Monitor Closely (1)meloxicam, hydrocortisone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • ibrutinib

    Monitor Closely (1)ibrutinib will increase the level or effect of meloxicam by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.

  • ibuprofen

    Monitor Closely (2)ibuprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.

    ibuprofen and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ibuprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ibuprofen IV

    Monitor Closely (2)ibuprofen IV and meloxicam both increase anticoagulation. Use Caution/Monitor.

    ibuprofen IV and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ibuprofen IV will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • imatinib

    Monitor Closely (2)imatinib will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

    imatinib, meloxicam.
    Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely.
    Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.

  • imidapril

    Minor (1)meloxicam decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • indapamide

    Monitor Closely (1)meloxicam increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • indomethacin

    Monitor Closely (2)indomethacin and meloxicam both increase anticoagulation. Use Caution/Monitor.

    indomethacin and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)indomethacin will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • irbesartan

    Monitor Closely (3)irbesartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of irbesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    irbesartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • isoproterenol

    Monitor Closely (1)meloxicam increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ketoconazole

    Minor (1)ketoconazole will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • ketoprofen

    Monitor Closely (2)ketoprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.

    ketoprofen and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ketorolac

    Monitor Closely (2)ketorolac and meloxicam both increase anticoagulation. Use Caution/Monitor.

    ketorolac and meloxicam both increase serum potassium. Use Caution/Monitor. Serious – Use Alternative (1)meloxicam, ketorolac.
    Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.Minor (1)ketorolac will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ketorolac intranasal

    Monitor Closely (2)ketorolac intranasal and meloxicam both increase anticoagulation. Use Caution/Monitor.

    ketorolac intranasal and meloxicam both increase serum potassium. Use Caution/Monitor.Serious – Use Alternative (1)meloxicam, ketorolac intranasal.
    Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.Minor (1)ketorolac intranasal will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • labetalol

    Monitor Closely (2)meloxicam decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    labetalol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • latanoprost

    Monitor Closely (1)latanoprost, meloxicam. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • latanoprostene bunod ophthalmic

    Monitor Closely (1)latanoprostene bunod ophthalmic, meloxicam. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • leflunomide

    Minor (1)leflunomide will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • levalbuterol

    Monitor Closely (1)meloxicam increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • levofloxacin

    Monitor Closely (1)levofloxacin, meloxicam. Other (see comment). Modify Therapy/Monitor Closely.
    Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

  • levomilnacipran

    Monitor Closely (1)levomilnacipran, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.

  • lisinopril

    Monitor Closely (1)lisinopril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, lisinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • lithium

    Monitor Closely (1)meloxicam increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.

  • lornoxicam

    Monitor Closely (2)lornoxicam and meloxicam both increase anticoagulation. Use Caution/Monitor.

    lornoxicam and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)lornoxicam will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • losartan

    Monitor Closely (3)losartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of losartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    losartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • meclofenamate

    Monitor Closely (2)meclofenamate and meloxicam both increase anticoagulation. Use Caution/Monitor.

    meclofenamate and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)meclofenamate will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • mefenamic acid

    Monitor Closely (2)mefenamic acid and meloxicam both increase anticoagulation. Use Caution/Monitor.

    mefenamic acid and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)mefenamic acid will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • mesalamine

    Monitor Closely (1)mesalamine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.Minor (1)meloxicam will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • metaproterenol

    Monitor Closely (1)meloxicam increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • methotrexate

    Serious – Use Alternative (1)meloxicam increases levels of methotrexate by decreasing renal clearance. Avoid or Use Alternate Drug. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity. .

  • methyclothiazide

    Monitor Closely (1)meloxicam increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .Minor (1)methyclothiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • methyl aminolevulinate

    Serious – Use Alternative (1)meloxicam, methyl aminolevulinate.
    Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

  • methylprednisolone

    Monitor Closely (1)meloxicam, methylprednisolone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • metolazone

    Monitor Closely (1)meloxicam increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)metolazone will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • metoprolol

    Monitor Closely (2)meloxicam decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    metoprolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • metronidazole

    Minor (1)metronidazole will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • miconazole vaginal

    Minor (1)miconazole vaginal will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • milnacipran

    Monitor Closely (1)milnacipran, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • mipomersen

    Monitor Closely (1)mipomersen, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

  • mistletoe

    Monitor Closely (1)meloxicam increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • moexipril

    Monitor Closely (1)moexipril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, moexipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • moxifloxacin

    Monitor Closely (1)moxifloxacin, meloxicam. Other (see comment). Modify Therapy/Monitor Closely.
    Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • moxisylyte

    Monitor Closely (1)meloxicam decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • mycophenolate

    Monitor Closely (1)meloxicam will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

  • nabumetone

    Monitor Closely (2)meloxicam and nabumetone both increase anticoagulation. Use Caution/Monitor.

    meloxicam and nabumetone both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • nadolol

    Monitor Closely (2)meloxicam decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    nadolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • naproxen

    Monitor Closely (2)meloxicam and naproxen both increase anticoagulation. Use Caution/Monitor.

    meloxicam and naproxen both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • nateglinide

    Minor (1)nateglinide will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • nebivolol

    Monitor Closely (2)meloxicam decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    nebivolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • nefazodone

    Monitor Closely (1)nefazodone, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • neomycin PO

    Minor (1)meloxicam increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • nettle

    Monitor Closely (1)meloxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nevirapine

    Monitor Closely (1)nevirapine will decrease the level or effect of meloxicam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • nilotinib

    Minor (1)nilotinib will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • noni juice

    Minor (1)meloxicam and noni juice both increase serum potassium. Minor/Significance Unknown.

  • norepinephrine

    Monitor Closely (1)meloxicam increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ofloxacin

    Minor (1)ofloxacin, meloxicam. Other (see comment). Minor/Significance Unknown.
    Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

  • olmesartan

    Monitor Closely (3)olmesartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of olmesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    olmesartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • oxaprozin

    Monitor Closely (2)meloxicam and oxaprozin both increase anticoagulation. Use Caution/Monitor.

    meloxicam and oxaprozin both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • panax ginseng

    Monitor Closely (1)meloxicam and panax ginseng both increase anticoagulation. Use Caution/Monitor.

  • parecoxib

    Monitor Closely (2)meloxicam and parecoxib both increase anticoagulation. Use Caution/Monitor.

    meloxicam and parecoxib both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • paromomycin

    Minor (1)meloxicam increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • paroxetine

    Monitor Closely (1)paroxetine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • pau d’arco

    Monitor Closely (1)meloxicam and pau d’arco both increase anticoagulation. Use Caution/Monitor.

  • pegaspargase

    Monitor Closely (1)pegaspargase increases effects of meloxicam by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of bleeding events.

  • pemetrexed

    Serious – Use Alternative (1)meloxicam increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug. Interrupt dosing in all patients taking NSAIDs with long elimination half-lives for at least 5d before, the day of, and 2d following pemetrexed administration. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity.

  • penbutolol

    Monitor Closely (2)meloxicam decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    penbutolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • pentobarbital

    Minor (1)pentobarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • perindopril

    Monitor Closely (1)perindopril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, perindopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • phenindione

    Monitor Closely (1)phenindione and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • phenobarbital

    Minor (1)phenobarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • phenoxybenzamine

    Monitor Closely (1)meloxicam decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • phentolamine

    Monitor Closely (1)meloxicam decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • phytoestrogens

    Monitor Closely (1)meloxicam and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

  • pindolol

    Monitor Closely (2)meloxicam decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    pindolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • pirbuterol

    Monitor Closely (1)meloxicam increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • piroxicam

    Monitor Closely (2)meloxicam and piroxicam both increase anticoagulation. Use Caution/Monitor.

    meloxicam and piroxicam both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • pivmecillinam

    Monitor Closely (2)pivmecillinam, meloxicam.
    Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

    pivmecillinam, meloxicam.
    Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • potassium acid phosphate

    Monitor Closely (1)meloxicam and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium chloride

    Monitor Closely (1)meloxicam and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium citrate

    Monitor Closely (1)meloxicam and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium iodide

    Monitor Closely (1)potassium iodide and meloxicam both increase serum potassium. Use Caution/Monitor.

  • pralatrexate

    Monitor Closely (1)meloxicam increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Adjust the pralatrexate dose as needed.

  • prasugrel

    Monitor Closely (1)meloxicam, prasugrel.
    Either increases effects of the other by anticoagulation. Use Caution/Monitor. Chronic use of NSAIDs with prasugrel may increase bleeding risk.

  • prazosin

    Monitor Closely (1)meloxicam decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • prednisolone

    Monitor Closely (1)meloxicam, prednisolone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • prednisone

    Monitor Closely (1)meloxicam, prednisone.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • primidone

    Minor (1)primidone will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • probenecid

    Monitor Closely (1)meloxicam will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

  • propranolol

    Monitor Closely (2)meloxicam decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    propranolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • protamine

    Monitor Closely (1)protamine and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • quinapril

    Monitor Closely (1)quinapril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, quinapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • ramipril

    Monitor Closely (1)ramipril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, ramipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • reishi

    Monitor Closely (1)meloxicam and reishi both increase anticoagulation. Use Caution/Monitor.

  • reteplase

    Monitor Closely (1)meloxicam and reteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • rifampin

    Minor (2)rifampin will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

    rifampin decreases levels of meloxicam by increasing metabolism. Minor/Significance Unknown.

  • rifapentine

    Minor (1)rifapentine will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • rivaroxaban

    Monitor Closely (1)rivaroxaban, meloxicam. Other (see comment). Use Caution/Monitor.
    Comment: NSAIDs are known to increase bleeding. Bleeding risk may be increased when NSAIDs are used concomitantly with rivaroxaban. Monitor for signs/symptoms of blood loss.

  • rivastigmine

    Monitor Closely (1)rivastigmine increases toxicity of meloxicam by pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for symptoms of active or occult gastrointestinal bleeding.

  • rose hips

    Minor (1)rose hips will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • sacubitril/valsartan

    Monitor Closely (3)sacubitril/valsartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    sacubitril/valsartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • salicylates (non-asa)

    Monitor Closely (2)meloxicam and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.

    meloxicam and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • salmeterol

    Monitor Closely (1)meloxicam increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • salsalate

    Monitor Closely (2)meloxicam and salsalate both increase anticoagulation. Use Caution/Monitor.

    meloxicam and salsalate both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • saw palmetto

    Monitor Closely (1)saw palmetto increases toxicity of meloxicam by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.

  • secobarbital

    Minor (1)secobarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • sertraline

    Monitor Closely (1)sertraline, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • Siberian ginseng

    Monitor Closely (1)meloxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

  • silodosin

    Monitor Closely (1)meloxicam decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • sodium picosulfate/magnesium oxide/anhydrous citric acid

    Monitor Closely (1)meloxicam, sodium picosulfate/magnesium oxide/anhydrous citric acid.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May be associated with fluid and electrolyte imbalances.

  • sodium polystyrene sulfonate

    Contraindicated (1)meloxicam increases toxicity of sodium polystyrene sulfonate by Other (see comment). Contraindicated.
    Comment: Cases of intestinal necrosis (possibly fatal) described with concomitant sorbitol and sodium polystyrene sulfonate; due to sorbitol in meloxicam oral suspension, coadministration is not recommended.

  • sodium sulfate/?magnesium sulfate/potassium chloride

    Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of meloxicam by Other (see comment). Use Caution/Monitor.
    Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium sulfate/magnesium sulfate

    Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of meloxicam by Other (see comment). Use Caution/Monitor.
    Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

    Monitor Closely (1)meloxicam, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Other (see comment). Use Caution/Monitor.
    Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance.

  • sotalol

    Monitor Closely (2)meloxicam decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    sotalol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • spironolactone

    Monitor Closely (1)spironolactone and meloxicam both increase serum potassium. Modify Therapy/Monitor Closely.

  • streptomycin

    Minor (1)meloxicam increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • succinylcholine

    Monitor Closely (1)meloxicam and succinylcholine both increase serum potassium. Use Caution/Monitor.

  • sulfamethoxazole

    Minor (1)sulfamethoxazole will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • sulfasalazine

    Monitor Closely (2)meloxicam and sulfasalazine both increase anticoagulation. Use Caution/Monitor.

    meloxicam and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • sulindac

    Monitor Closely (2)meloxicam and sulindac both increase anticoagulation. Use Caution/Monitor.

    meloxicam and sulindac both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • tacrolimus

    Serious – Use Alternative (1)meloxicam, tacrolimus.
    Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug.
    Comment: Concomitant administration increases risk of nephrotoxicity.

  • tafluprost

    Monitor Closely (1)tafluprost, meloxicam. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • telmisartan

    Monitor Closely (3)telmisartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of telmisartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    telmisartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • temocillin

    Monitor Closely (2)temocillin, meloxicam.
    Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

    temocillin, meloxicam.
    Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • tenecteplase

    Monitor Closely (1)meloxicam and tenecteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • tenofovir DF

    Monitor Closely (1)tenofovir DF, meloxicam.
    Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of tenofovir DF with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • terazosin

    Monitor Closely (1)meloxicam decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • terbutaline

    Monitor Closely (1)meloxicam increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ticagrelor

    Monitor Closely (1)ticagrelor, meloxicam.
    Either increases effects of the other by anticoagulation. Use Caution/Monitor. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. .

  • ticarcillin

    Monitor Closely (2)ticarcillin, meloxicam.
    Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

    ticarcillin, meloxicam.
    Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • ticlopidine

    Minor (1)ticlopidine will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • timolol

    Monitor Closely (2)meloxicam decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

    timolol and meloxicam both increase serum potassium. Use Caution/Monitor.

  • tobramycin

    Minor (1)meloxicam increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • tolazamide

    Monitor Closely (1)meloxicam increases effects of tolazamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • tolbutamide

    Monitor Closely (1)meloxicam increases effects of tolbutamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • tolfenamic acid

    Monitor Closely (2)meloxicam and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.

    meloxicam and tolfenamic acid both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • tolmetin

    Monitor Closely (2)meloxicam and tolmetin both increase anticoagulation. Use Caution/Monitor.

    meloxicam and tolmetin both increase serum potassium. Use Caution/Monitor.Minor (1)meloxicam will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • tolvaptan

    Monitor Closely (1)meloxicam and tolvaptan both increase serum potassium. Use Caution/Monitor.

  • torsemide

    Monitor Closely (1)meloxicam increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • trandolapril

    Monitor Closely (1)trandolapril, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious – Use Alternative (1)meloxicam, trandolapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

  • travoprost ophthalmic

    Monitor Closely (1)travoprost ophthalmic, meloxicam. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • trazodone

    Monitor Closely (1)trazodone, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • triamcinolone acetonide injectable suspension

    Monitor Closely (1)meloxicam, triamcinolone acetonide injectable suspension.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. .

  • triamterene

    Monitor Closely (1)triamterene and meloxicam both increase serum potassium. Modify Therapy/Monitor Closely.Minor (2)triamterene, meloxicam. Other (see comment). Minor/Significance Unknown.
    Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.

    meloxicam increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

  • valganciclovir

    Minor (1)meloxicam will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • valproic acid

    Minor (1)valproic acid will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • valsartan

    Monitor Closely (3)valsartan, meloxicam.
    Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.
    Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

    meloxicam decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

    valsartan and meloxicam both increase serum potassium. Use Caution/Monitor.

  • vancomycin

    Minor (1)meloxicam increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.

  • venlafaxine

    Monitor Closely (1)venlafaxine, meloxicam.
    Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • vitamin K1 (phytonadione)

    Monitor Closely (1)meloxicam increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • voclosporin

    Monitor Closely (1)voclosporin, meloxicam.
    Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

  • vorapaxar

    Monitor Closely (1)meloxicam, vorapaxar.
    Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.

  • voriconazole

    Minor (1)voriconazole will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • vortioxetine

    Monitor Closely (1)meloxicam, vortioxetine.
    Either increases effects of the other by anticoagulation. Use Caution/Monitor.

  • warfarin

    Monitor Closely (1)warfarin and meloxicam both increase anticoagulation. Modify Therapy/Monitor Closely.

  • willow bark

    Minor (1)meloxicam will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • zafirlukast

    Minor (1)zafirlukast will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • zanubrutinib

    Monitor Closely (1)meloxicam, zanubrutinib.
    Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.

  • zotepine

    Monitor Closely (1)meloxicam decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • Mobic (meloxicam) Tablets | CenterWatch

    General Information

    Mobic (meloxicam) is a non-steroidal anti-inflammatory drug (NSAID).

    Mobic is specifically indicated for:

    • relief of the signs and symptoms of osteoarthritis
    • relief of the signs and symptoms of rheumatoid arthritis
    • relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis in patients who weigh ≥60 kg

    Mobic is supplied as tablets for oral administration. In adults, the maximum recommended daily oral dose of Mobic is 15 mg regardless of formulation. In patients with hemodialysis, a maximum daily dosage of 7.5 mg is recommended. Mobic may be taken without regard to timing of meals.

    The recommended dosing is as follows:

    Osteoarthritis

    • For the relief of the signs and symptoms of osteoarthritis the recommended starting and maintenance oral dose of Mobic is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.

    Rheumatoid Arthritis

    • For the relief of the signs and symptoms of rheumatoid arthritis, the recommended starting and maintenance oral dose of Mobic is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.

    Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polyarticular Course

    • For the treatment of juvenile rheumatoid arthritis, the recommended oral dose of Mobic is 7.5 mg once daily in children who weigh ≥60 kg. There was no additional benefit demonstrated by increasing the dose above 7.5 mg in clinical trials. Mobic tablets should not be used in children who weigh <60 kg.

    Mechanism of Action

    Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in models. The mechanism of action of meloxicam, like that of other NSAIDs, may be related to prostaglandin synthetase (cyclooxygenase) inhibition.

    Side Effects

    Adverse effects associated with the use of Mobic may include, but are not limited to, the following:

    • diarrhea
    • upper respiratory tract infections
    • dyspepsia
    • influenza like symptoms

    The Mobic drug label comes with the following Black Box Warning: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Mobic is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

    Clinical Trial Results

    Osteoarthritis

    A double-blind, controlled study was conducted in the U.S. to evaluate the safety and efficacy of Mobic. The 12-week study involved 464 patients who had osteoarthritis of the knee and hip. When three different doses of Mobic (3.5 mg, 7.5 mg, and 15 mg daily) were compared to placebo, results indicated that both the 7.5 and 15 mg daily doses of Mobic significantly decreased symptoms of pain, function, and stiffness in patients, with a low incidence of gastrointestinal side effects. Six similar studies were conducted outside of the U.S. Results were consistent with those found in the U.S. study.

    Rheumatoid Arthritis

    The use of Mobic for the treatment of the signs and symptoms of rheumatoid arthritis was evaluated in a 12-week, double-blind, controlled multinational trial. Mobic (7.5 mg, 15 mg, and 22.5 mg daily) was compared to placebo. The primary endpoint in this study was the ACR20 response rate, a composite measure of clinical, laboratory, and functional measures of RA response. Patients receiving Mobic 7.5 mg and 15 mg daily showed significant improvement in the primary endpoint compared with placebo. No incremental benefit was observed with the 22.5 mg dose compared to the 15 mg dose.

    Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polyarticular Course

    The use of Mobic for the treatment of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis in patients 2 years of age and older was evaluated in two 12-week, double-blind, parallel-arm, active-controlled trials. Both studies included three arms: naproxen and two doses of meloxicam. In both studies, meloxicam dosing began at 0.125 mg/kg/day (7.5 mg maximum) or 0.25 mg/kg/day (15 mg maximum), and naproxen dosing began at 10 mg/kg/day. One study used these doses throughout the 12-week dosing period, while the other incorporated a titration after 4 weeks to doses of 0.25 mg/kg/day and 0.375 mg/kg/day (22.5 mg maximum) of meloxicam and 15 mg/kg/day of naproxen. The efficacy analysis used the ACR Pediatric 30 responder definition, a composite of parent and investigator assessments, counts of active joints and joints with limited range of motion, and erythrocyte sedimentation rate. The proportion of responders were similar in all three groups in both studies, and no difference was observed between the meloxicam dose groups.

    Meloxicam [Mobic] in Juvenile Rheumatoid Arthritis (JRA) – Full Text View

    107.235.23 Arkansas Children’s Hospital
    Little Rock, Arkansas, United States
    107.235.17 Valley Children’s Hospital
    Madera, California, United States
    107.235.37
    San Diego, California, United States
    107.235.4 Boehringer Ingelheim Investigational Site
    Denver, Colorado, United States
    107.235.12 Boehringer Ingelheim Investigational Site
    Hartford, Connecticut, United States
    107.235.13 Alfred I. DuPont Hospital for Children
    Wilmington, Delaware, United States
    107.235.36 Arthritis Associates Clinical Research of South Florida
    Del Ray Beach, Florida, United States
    107.235.21 Miami Children’s Hospital
    Miami, Florida, United States
    107.235.38 Clinical Research Dept #7006
    St. Petersberg, Florida, United States
    107.235.8 Boehringer Ingelheim Investigational Site
    Chicago, Illinois, United States
    107.235.7 Boehringer Ingelheim Investigational Site
    Kansas City, Kansas, United States
    107.235.25 University of Louisville
    Louisville, Kentucky, United States
    107.235.16 Children’s Hospital – Department of Rheumatology
    New Orleans, Louisiana, United States
    107.235.26 Deparment of Rheumatology
    Boston, Massachusetts, United States
    107.235.2 E15 Mayo Clinic
    Rochester, Minnesota, United States
    107.235.18 Washington University School of Medicine
    St. Louis, Missouri, United States
    107.235.9 Boehringer Ingelheim Investigational Site
    St. Louis, Missouri, United States
    107.235.31 Department of Pediatrics
    Omaha, Nebraska, United States
    107.235.35 Arthritis and Rheumatic Disease Center
    Livingston, New Jersey, United States
    107.235.24 The Children’s Hospital of Buffalo
    Buffalo, New York, United States
    107.235.19 Columbia Presbyterian Medical Center
    New York, New York, United States
    107.235.22 Oklahoma Medical Research Foundation
    Oklahoma City, Oklahoma, United States
    107.235.33 Healthcare Research Consultants
    Tulsa, Oklahoma, United States
    107.235.32 Arthritis and Osteoporosis Center
    Duncansville, Pennsylvania, United States
    107.235.39 Division of Ambulatory Pediatrics
    Providence, Rhode Island, United States
    107.235.10 Texas Scottish Rite Hospital
    Dallas, Texas, United States
    107.235.1 University of Utah School of Medicine
    Salt Lake CIty, Utah, United States
    107.235.30 Children’s Hospital
    Seattle, Washington, United States
    107.235.20 Medical College of Wisconsin
    Milwaukee, Wisconsin, United States
    107.235.61
    Cerqueira César, Brazil
    107.235.62
    Santa Cecília, Brazil
    107.235.60
    Sao Paulo, Brazil
    107.235.40
    México, D.F., Mexico
    107.235.71 Institute of Children and Adolescents Health
    Kharkov, Ukraine
    107.235.70 Children Clinical Hospital No. 1
    Kiev, Ukraine
    107.235.72 Institute of Pediatrics
    Kiev, Ukraine
    107.235.73 2nd Children Specialized Clinical Hospital “OHMADIT”
    Kiev, Ukraine

    8 Uses of Meloxicam (Mobic) + Side Effects

    Meloxicam (Mobic) is a relatively newer medication used for pain relief. It is commonly used for osteoarthritis and rheumatoid arthritis. It may also cause side effects and interactions that patients should be aware of. Learn about the uses of meloxicam as well as the health risks.

    What is Meloxicam?

    Meloxicam is a prescription medication that belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAID). This class of drugs is typically used to help reduce fever, pain, and inflammation [1].

    NSAIDs are associated with several health risks, including side effects that impact the stomach and heart. Meloxicam may have a lower risk of stomach side effects due to how it works [1].

    Meloxicam is FDA-approved to treat chronic inflammatory diseases, including osteoarthritis and rheumatoid arthritis in adults and children. It is also used off-label for other painful conditions, such as lower back pain and pain after surgery [2, 3].

    Mechanism of Action

    Meloxicam primarily works by blocking COX enzymes [4].

    There are two types of COX enzymes, COX-1 and COX-2. Both of these enzymes are responsible for producing various compounds, including prostaglandins and thromboxane [5].

    Prostaglandins play a number of different roles in the body, such as regulating inflammation, pain, and fever. For this reason, NSAIDs can reduce pain and inflammation by blocking COX enzymes, which reduces the amount of prostaglandins produced [5].

    However, prostaglandins also protect the stomach by regulating acid and mucus production. By blocking prostaglandin activity, NSAIDs can cause problems in the stomach, like ulcers [5].

    Meloxicam is unique among NSAIDs because it has selective activity on COX-2. The COX-2 enzyme is not present in the stomach like COX-1 is. This means that meloxicam may not cause as many side effects in the stomach compared to NSAIDs that are non-selective for COX enzymes [4].

    Meloxicam Uses

    FDA-Approved Uses

    1) Osteoarthritis

    Osteoarthritis (OA) is a common form of arthritis that affects the joint cartilage that protects the ends of the bones. A number of clinical trials show that meloxicam can reduce pain and inflammation associated with this condition.

    For example, a 12-week randomized placebo-controlled trial including 774 patients with OA found that meloxicam can reduce symptoms of pain and stiffness. In the study, the number of stomach side effects did not differ between meloxicam and placebo [6].

    Meloxicam also reduced pain in a 6-month multicenter randomized trial of 336 patients with OA. Meloxicam caused fewer side effects than diclofenac, another type of NSAID [7].

    In another randomized trial of 229 patients with OA of the lumbar spine, meloxicam improved pain and movement. Meloxicam was better tolerated than diclofenac once again [8].

    2) Rheumatoid Arthritis in Adults

    Rheumatoid arthritis (RA) is an autoimmune disorder where the body’s immune system attacks its own cells, causing pain and inflammation throughout the body. Meloxicam is approved to treat rheumatoid arthritis in both adults and children [3].

    A 12-week randomized placebo-controlled trial of 894 patients with RA suggests that meloxicam may reduce joint swelling, tenderness, pain, and overall symptoms. Meloxicam did not cause significantly more stomach side effects compared to placebo [9].

    In a 6 month double-blind trial of 379 patients with RA, meloxicam reduced joint pain and swelling better than naproxen, another common NSAID. Significantly more patients had to discontinue naproxen due to stomach side effects than those on meloxicam [10].

    According to an 18-month long-term trial of 357 patients with RA, meloxicam may reduce stiffness and pain, while increasing grip st65rength. When taken daily for 1.5 years, meloxicam was deemed safe, but about 1/3 of patients did experience stomach side effects [11].

    Meloxicam is also available as an intramuscular injection. Injections may have similar effectiveness to oral forms, according to a randomized trial of 173 patients with RA. Other studies have found similar results. Injections may have some benefits over oral forms, such as quicker onset of action [12, 13].

    3) Rheumatoid Arthritis in Children

    Children under the age of 16 can have a type of arthritis called juvenile rheumatoid arthritis. Meloxicam is FDA-approved to treat this condition in patients 2 years of age or older. A liquid suspension form of meloxicam is often used for children [3].

    An international multicenter randomized trial of 232 children evaluated the short-term (3 months) and long-term safety and effectiveness of daily meloxicam in liquid form. The researchers suggest that meloxicam is safe and effective for both short-term and long-term use in children [14].

    Off-Label Uses

    Meloxicam is used for several off-label conditions, which we’ll discuss in the following sections. If you are prescribed this medication, always take the medication as directed by your doctor.

    4) Lower Back Pain

    A randomized controlled trial of 169 patients with lower back pain (lumbago) found that a 1-week treatment with meloxicam injection and oral doses may reduce pain and limitations to daily life. Other studies have found similar results [15, 16, 17].

    Intravenous (IV) meloxicam is also an option for patients in need of immediate pain relief, as the medication can act quickly (within 30 minutes) when given this way [18].

    In a randomized controlled trial of 183 patients experiencing sudden lower back pain, meloxicam IV injections followed by daily tablets for 8 days significantly reduced pain [18].

    5) Sciatica

    Sciatica can be caused by inflammation or pressure on the sciatic nerves in the lower back, which causes pain that can spread down into the legs. Research suggests that meloxicam may be an alternative to opioids for nerve pain relief [19].

    In a 6-year open-label study of 72 patients with painful nerve inflammation (including sciatica), meloxicam injections provided long-term pain relief to most patients after 1 to 3 doses [16].

    Two randomized placebo-controlled trials with 532 and 489 patients each found that oral meloxicam may be effective for sudden (acute) sciatica [20].

    6) Neck Pain

    An open-label study of 48 patients with neck and shoulder pain found that 1-3 injections of meloxicam may provide pain relief that lasts up to 90 days. In the study, the functional activity level of all patients increased after receiving the injection [21].

    7) Pain Associated with Dental Surgery

    In a randomized trial of 60 patients with inflammatory gum disease, an adhesive film containing meloxicam was applied to the gums after gum surgery for 3 days. Researchers found that the higher doses of meloxicam film (30 and 45 mg) may reduce pain after dental surgery [22].

    A randomized study of 36 patients suggests that one dose of oral meloxicam before a molar tooth extraction may reduce post-surgery pain, swelling, and symptoms of lockjaw (trismus) [23].

    8) Pain After Surgery

    Meloxicam is sometimes given as a single dose to reduce pain after surgery. However, a systematic review did not identify any strong clinical trials that support this use [24].

    Meloxicam Safety

    Side Effects

    Meloxicam can cause several side effects. If any side effects persist or worsen, let your doctor know. This is also not a complete list of possible side effects. Tell your doctor if you experience any serious side effects or notice any effects not listed here.

    Some common side effects include [3]:

    • Dizziness
    • Nausea
    • Upset stomach
    • Diarrhea
    • Upper respiratory tract infections
    • Indigestion
    • Flu-like symptoms

    Some serious side effects include [3]:

    • Bloody or black stools
    • Severe stomach pain
    • Severe or persistent headache
    • Swelling in the ankles or feet
    • Sudden weight gain
    • Dark urine
    • Persistent nausea or vomiting

    Warnings

    Heart Risks

    Meloxicam is associated with an increased risk for serious cardiovascular complications, including heart attack and stroke. Meloxicam should be used cautiously in patients with heart conditions, such as heart failure [25].

    Gastrointestinal Risks

    Meloxicam is associated with an increased risk for serious gastrointestinal complications, including ulcers and bleeding. Patients taking meloxicam, especially elderly patients and those with a history of peptic ulcer disease, should be aware of these risks and symptoms [25].

    Liver Toxicity

    There’s evidence that meloxicam may have toxic effects on the liver. This medication should be discontinued if there are any signs or symptoms of liver disease [25].

    Kidney Toxicity

    Meloxicam may be toxic to the kidneys. Patients on meloxicam should have their renal function monitored. This medication should not be used in those with advanced kidney disease unless a doctor determines that the benefits outweigh the risks [25].

    Contraindications

    Meloxicam should not be taken if a patient has any of the following [3]:

    • Allergies or sensitivity to meloxicam
    • Any allergies to aspirin or other NSAIDs
    • Is undergoing CABG surgery

    Pregnancy and Breastfeeding

    There’s evidence that meloxicam may increase the risk of birth defects when taken during the third trimester of pregnancy. The FDA recommends avoiding the use of NSAIDs, in general, starting in the third trimester (30 weeks) of pregnancy [3].

    It’s unclear if meloxicam is present in breast milk. A doctor will weigh the benefits and risks when determining if the use of meloxicam is appropriate during breastfeeding.

    Drug Interactions

    The following drugs have been reported to interact with meloxicam. However, this is not a complete list, let your doctor know of all the medications you are currently taking to avoid any unexpected interactions.

    • Aspirin – Use of meloxicam together with aspirin (even at low doses) is not recommended and can increase the risk of stomach damage [26].
    • ACE Inhibitors – Meloxicam can reduce the blood pressure-lowering effect of ACE inhibitors [27].
    • Lithium – Meloxicam may dangerously increase lithium levels, causing overdose [28].
    • Warfarin – There is an increased risk of severe bleeding (internal or external) in combination with meloxicam [29].

    Meloxicam Dosage

    The dosing of meloxicam can vary. Always take this medication as directed by a doctor.

    Meloxicam is available as tablets, capsules, liquid suspensions, and injections (IV or IM). Gels and patches are also being developed [30, 31].

    In general, meloxicam should be used at the lowest effective dose for the shortest duration possible for pain relief.

    Tablets are available in strengths of 7.5 and 15 mg.

    For osteoarthritis and rheumatoid arthritis in adults, patients are usually started on 7.5 mg per day, which may be increased to 15 mg per day if needed.

    Complementary Options

    The following section details some complementary options that may help with pain. You should always consult your doctor before changing or stopping your medications.

    It’s also important to let your doctor know of all the supplements you are currently taking, in case of potential interactions. These alternatives should not be used to replace medical treatment.

    Fish Oil

    There’s some evidence that fish oils (DHA and EPA) may help reduce pain and inflammation.

    A review of 42 clinical trials found that fish oil supplements may help reduce pain associated with osteoarthritis and rheumatoid arthritis. However, the quality of evidence was low for osteoarthritis, while the quality was only moderate for rheumatoid arthritis [32].

    White Willow Bark

    White willow bark (Salix alba) contains salicin, the same compound that aspirin is derived from [33, 34].

    A review of 14 clinical trials involving 2,050 participants suggests that white willow bark may reduce lower back pain. However, the quality of evidence was moderate at best [35].

    Willow bark also shares many of the same safety concerns with aspirin, including interactions with blood thinners and the risk of Reye’s syndrome in children [36, 37].

    Resveratrol

    Resveratrol is a compound found in many foods, like berries, peanuts, and most famously in red wine [38].

    Resveratrol may be effective as an add-on to conventional NSAIDs. A randomized trial of 110 people with osteoarthritis of the knee found that resveratrol supplements plus meloxicam may provide more pain relief than meloxicam alone [39].

    Boswellia, Curcumin, and Pycnogenol

    A systematic review investigated the effectiveness of 20 different supplements for pain associated with osteoarthritis. According to the 69 trials included in the review, Boswellia, curcumin, and Pycnogenol may be effective for short-term pain relief [40].

    However, the researchers concluded that the quality of evidence was very low. There was also no evidence that these supplements improve long-term pain [40].

    Alcohol & Mobic – The Recovery Village Drug and Alcohol Rehab

    If you have chronic pain, you may be prescribed a pain medication called Mobic. This drug works very well against some types of pain, making it easier for you to take part in your daily activities. Unfortunately, if your normal activities include drinking alcohol, you may be putting yourself at risk. Combining Mobic and alcohol can harm your health.

    Article at a Glance:

    Important points to remember about alcohol and Mobic include:

    • Mobic is a prescription-strength NSAID drug which should not be mixed with alcohol
    • Your risk of bleeding, especially in your stomach and intestines, increases if you drink and use Mobic
    • Your risk of gout flares, for which Mobic is prescribed, increases if you drink alcohol
    • Your risk of gastritis is higher if you combine alcohol and Mobic
    • Mobic and drinking alcohol can harm the heart and lead to cardiovascular problems

    Mixing Alcohol and Mobic

    Mobic is one of several brand names for the drug meloxicam. The drug is also sold under other brand names of Vivlodex and Qmiiz. Mobic belongs to a class of medicines called non-steroidal anti-inflammatory drugs, or NSAIDs. Mobic is a very strong NSAID and is only available with a prescription.

    Mobic treats pain related to:

    • Different forms of arthritis, including rheumatoid arthritis and osteoarthritis
    • Gout flares
    • Other pain conditions

    Mixing alcohol and Mobic can be dangerous, as it can increase your risk of several complications, including:

    Bleeding Risk

    Doctors advise not to drink alcohol while taking Mobic because, like other NSAIDs, Mobic can increase bleeding risk. Although doctors do not know how NSAIDs increase bleeding risk, many different studies have found that internal bleeding can occur. The Food and Drug Administration (FDA) has put a black box warning on prescription NSAIDs like Mobic because it can cause bleeding.

    The warning is for increased risk of:

    • Bleeding
    • Ulcers
    • Holes in your stomach or intestine

    Alcohol use and abuse can also increase bleeding risk. The more you drink, and the longer you drink, the more you are at risk of bleeding from drinking. Drinking harms your body’s ability to make a type of blood cell called platelets. Platelets help your blood clot when you are bleeding. However, if you struggle with alcohol use, your body often has trouble making platelets.

    In some cases, your body may make platelets that are abnormal and do not work as well as they should. This condition can be harmful, because if your platelets cannot stop bleeding, then you may continue to bleed internally. Sometimes you may not even know that you are bleeding, especially if the bleeding is on the inside of your body.

    Because both alcohol and Mobic can each increase bleeding risk, using them together can be dangerous. Doctors think that if you use alcohol and Mobic together, your risk of bleeding may be even higher.

    Gastritis Risk

    Both alcohol and Mobic increase your risk of gastritis, which is inflammation of the stomach. Therefore, using alcohol and Mobic together can make your risk of gastritis even higher.

    Gastritis can cause health problems like:

    • Ulcers
    • Permanent stomach damage
    • Low blood iron, which means your blood cells cannot transport oxygen as well as they should
    • Low vitamin B12, which can cause mental changes and irreversible nerve damage
    • Stomach cancer

    Gout Risk

    If you are taking Mobic for gout flares, it is crucial to remember that drinking can cause a gout flare. Therefore, it is doubly important to avoid alcohol if the reason you are taking Mobic is gout.

    If you are drinking alcohol while using Mobic for a gout flare, it is also important to look out for gout symptoms like:

    • Severe pain in a single joint (often your big toe)
    • Swelling in a single joint
    • Redness in a single joint
    • Feeling like a single joint is hot when you touch it

    Heart Attack and Stroke

    The FDA has a black box warning on NSAIDs like Mobic for increasing the risk of heart attack and stroke.

    Watch for symptoms of a heart attack or stroke, including:

    • Chest pain
    • Shortness of breath
    • Left arm or shoulder pain
    • Exhaustion (in women)
    • Nausea (in women)
    • Weakness on one side of the body
    • Sudden changes in vision
    • Suddenly slurred speech

    Excessive use of alcohol can also lead to problems with the heart, including cardiomyopathy, which is a condition that can lead to heart failure. Therefore, mixing alcohol and NSAIDs like Mobic is not recommended as it increases the risk of heart problems.

    Symptoms of Mixing Alcohol and Mobic

    Because mixing alcohol and Mobic can increase your risk of bleeding in your stomach and intestines, it is essential to be aware of bleeding symptoms, including:

    • Red blood in your vomit
    • Red blood in your stool
    • Particles that look like coffee grounds in your vomit
    • Stool that is black and tarry

    As Mobic and alcohol can increase your risk of gastritis, it is also important to be aware of gastritis symptoms like:

    • Stomach pain
    • Stomach discomfort
    • Nausea or vomiting

    If you or a loved one struggle with alcohol addiction, a compassionate team of medical professionals at The Recovery Village Drug and Alcohol Rehab can help. We offer many different addiction treatment options to help you lead a healthier life. Contact us today for more information on how to lead a life free from drinking.

    • Sources
      1. DailyMed. “Mobic.” Updated October 11, 2018. Accessed June 7, 2019.
      2. Ballard, Harold S. “The Hematological Complications of Alcoholism.” Alcohol Health and Research World, 1997. Accessed June 7, 2019.
      3. The National Institute of Diabetes and Digestive and Kidney Diseases. “Gastritis.” Published July 2015. Accessed June 7, 2019.
      4. The Centers for Disease Control and Prevention. “Gout.” Reviewed January 28, 2019. Accessed June 7, 2019.
      5. The National Institutes of Health, News in Health. “Can You Recognize a Heart Attack or Stroke?” Published August 2014. Accessed June 7, 2019.

    Meloxicam (Anti-inflammatory Painkiller) | Patient

    About meloxicam

    Type of medicine Non-steroidal anti-inflammatory drug (NSAID)
    Used for Pain and inflammation in rheumatoid arthritis, ankylosing spondylitis and osteoarthritis
    Available as Tablets and melt-in-the-mouth (orodispersible) tablets

    Anti-inflammatory painkillers like meloxicam are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just ‘anti-inflammatories’. Meloxicam eases pain and swelling (inflammation) in long-term conditions like rheumatoid arthritis and ankylosing spondylitis, but it may also be used for a shorter period of time in osteoarthritis.

    Meloxicam works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

    Before taking meloxicam

    Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meloxicam, it is important that your doctor or pharmacist knows:

    • If you have asthma or any other allergic disorder.
    • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
    • If you are pregnant, trying for a baby or breastfeeding.
    • If you have liver or kidney problems.
    • If you have a heart condition or a problem with your blood vessels or circulation.
    • If you have high blood pressure.
    • If you have high blood sugar or cholesterol levels.
    • If you are a smoker.
    • If you have ever had blood clotting problems.
    • If you have systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.
    • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as as herbal and complementary medicines.
    • If you have ever had an allergic reaction to any other NSAID (such as aspirin, ibuprofen, diclofenac, and indometacin), or to any other medicine.

    How to take meloxicam tablets

    • Before you start taking meloxicam, read the manufacturer’s printed information leaflet from inside the pack. The leaflet will give you more information about the tablets and provide a full list of side-effects which you may experience from taking them.
    • Take meloxicam exactly as your doctor has told you to. The usual dose is one tablet a day. You will be prescribed either 7.5 mg tablets or 15 mg tablets.
    • Swallow the tablet whole with a drink of water.
    • Take each dose with a snack or just after eating a meal and drink plenty of water whilst on meloxicam.
    • If your doctor has prescribed melt-in-the-mouth (orodispersible) tablets:
      • Moisten your mouth first, taking a sip of water if needed.
      • Remove the tablet from the packaging, taking care not to moisten it.
      • Place the tablet on your tongue and allow it to dissolve slowly. This should take about five minutes.
      • After five minutes drink a large glass of water and swallow the dissolved tablet.
      • Do not chew the tablet or swallow it before it has dissolved.
    • Try to take your doses at the same time each day, as this will help you to remember to take them.
    • If you do forget to take a dose, take it as soon as you remember along with something to eat. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

    Getting the most from your treatment

    • Your doctor will try to prescribe you the lowest dose for the shortest time to reduce the risk of side-effects. Your doctor may also want to prescribe another medicine for you to take along with meloxicam to protect your stomach from irritation.
    • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
    • If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories like meloxicam. If this happens to you, you should stop taking the tablets and see your doctor as soon as possible.
    • If you buy any medicines, check with a pharmacist that they are safe to take with an anti-inflammatory like meloxicam.
    • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

    Can meloxicam cause problems?

    Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

    Common meloxicam side-effects
    What can I do if I experience this?
    Feeling sick (nausea) or being sick (vomiting) Stick to simple foods. Drink plenty of liquid to replace any lost fluids
    Loose, watery stools (diarrhoea) Stick to simple foods. Drink plenty of liquid to replace any lost fluids
    Constipation Try to eat more foods that are high in fibre, such as fruits and vegetables, and drink plenty of water
    Indigestion, stomach discomfort, wind Remember to take the tablets after a meal if you are not already doing so. If the discomfort continues, speak with your doctor
    Other less common side-effects: headache, feeling dizzy or sleepy, nervousness, mood changes, difficulty sleeping, a spinning sensation (vertigo), and ringing noises (tinnitus) If any of these become troublesome, speak with your doctor

    Important: if you experience any of the following uncommon but possibly serious symptoms, stop taking meloxicam and contact your doctor for advice straightaway:

    • If you have any breathing difficulties such as wheeze or breathlessness.
    • If you have any signs of an allergic reaction such as swelling around your mouth or face, or an itchy skin rash.
    • If you pass blood or black stools, vomit blood, or have tummy (abdominal) pains.

    If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

    How to store meloxicam

    • Keep all medicines out of the reach and sight of children.
    • Store in a cool, dry place, away from direct heat and light.
    • Keep the tablets in their original packaging. 

    Important information about all medicines

    Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

    This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

    Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

    If you have any questions about this medicine ask your pharmacist.

    Discount Generic & Prescription Drugs

    GENERIC ALTERNATIVE LISTING – Meloxicam

    Price Guarantee

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    Dosage: 

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    Pack Size & Price: 

    Pack Size – Price30.00 pills – $26.0990.00 pills – $35.09180.00 pills – $69.49

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    BRAND LISTING – Mobic (Meloxicam)

    Price Guarantee

    Dosage Pack Size & Price Qty

    Dosage: 

    7.5mg

    Pack Size & Price: 

    Pack Size – Price100.00 pills – $148.29 (Out Of Stock)

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    Mobic Description

    Mobic or the generic alternative called Meloxicam is a non-steroidal anti-inflammatory drug referred to as an NSAID. If you are enduring the pain of arthritis, your doctor may prescribe Mobic to reduce the joint pain and swelling that inflammation can cause. Prescription strength Mobic or generic Meloxicam is taken orally, usually once per day and may be taken with or without food. The generic alternative is not manufactured by the company that makes the brand product.

    How This Cyclooxygenase Inhibitor Works to Reduce Inflammation

    When taken as directed, Mobic and Meloxicam generic works as a non-selective cyclooxygenase (COX) inhibitor. This means that its purpose is to block both of the enzymes (COX 1 and COX 2) that are responsible for the production of prostaglandins, a chemical that causes the pain and swelling as an immune response to injury.

    Conditions Treated by Mobic

    Arthritis is an ongoing inflammatory disease that occurs because of cartilage erosion and degradation of your synovial tissue and fluid that cushions your joints. Osteoarthritis is the most common form of arthritis and can happen from normal wear and tear on your body joints over the years. Mobic will not cure your arthritis, but it can help bring you relief from joint pain so you can perform daily tasks and enjoy other activities.

    Rheumatoid arthritis is the 2nd most common type of chronic arthritis that occurs in joints on both sides of the body. Rheumatoid arthritis can also affect other body parts such as skin, eyes, heart, lungs, nerves or blood. This is an autoimmune disease which means that the body’s immune system attacks its own healthy tissues when it believes a threat is imminent and is characterized by joint swelling and pain, stiffness, and fatigue.

    Before Mobic is Prescribed

    Advise your doctor if you have any of the following medical conditions that may affect your ability to safely take Mobic: seizure disorder; nasal polyps; asthma; liver or kidney disease; stomach ulcers; high blood pressure; history of heart attack or stroke. It is important to tell your doctor about any medications you are taking to know if there is a risk of an adverse reaction with Mobic.

    Mobic Risks and Precautions

    Taking Mobic or generic Meloxicam may increase your risk of stroke or heart attack. Keep Mobic out of children’s reach and never share your meds with anyone else. Long-term use of Mobic should be monitored by your doctor as it suppresses your immune system.

    Possible Side Effects of Mobic

    • Nausea
    • Diarrhea
    • Dizziness
    • Abdominal pain

    You should contact your physician if you experience any of the following more serious side effects associated with meloxicam: back pain; lack of energy; fast heartbeat; weight gain; difficult or painful urination.

    Drugs Similar to Mobic

    The information provided on the NorthWestPharmacy.com website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.

    Mobil ™ | Russia

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    Office Mobile Windows 10 Apps Getting Started

    Note: We strive to provide you with up-to-date reference materials in your language as quickly as possible.This page has been automatically translated and may contain inaccuracies and grammatical errors. It is important for us that this article is useful to you. We ask you to take a couple of seconds and let us know if she helped you using the buttons at the bottom of the page. For convenience, we also provide a link to the original (in English).

    The Office Mobile applications (Word Mobile, Excel Mobile, PowerPoint Mobile, and OneNote) are touch-based, offer familiar experiences for Office users and give users the ability to work on the go.

    Note: This article applies to Office Mobile applications on a tablet or touchscreen computer with Windows 10.

    Install applications

    You may already have applications installed. However, if you’ve installed Windows 10 or purchased a new device, you can install them.

    How to find applications

    To find mobile apps, tap All apps in Windows 10.If you want the desktop versions, click All Applications , and then select the Microsoft Office folder.

    Word Mobile Features

    “Reading View” – a new way of viewing documents: Word improved the flow of the document to adapt to small screens. And Bing-powered smart search brings additional online resources, such as images and web links, directly into a document to provide you with more details and new ideas.

    Excel Mobile Capabilities

    All the power and precision of Excel is now lightweight for mobile devices. In this animation, we will show you how to enter a formula. When using the on-screen keyboard, you’ll find familiar touch-friendly controls so you can work with extended spreadsheets on a small tablet.

    PowerPoint Mobile Features

    This animation shows you how to scroll through your presentation.But PowerPoint Mobile can do more. You can easily create gorgeous slides, and use all the transitions and animations familiar to you on a desktop computer. In addition, new ink, laser pointer, and highlighting features let you focus on key concepts.

    Features OneNote on Tablet

    Record, organize and share your ideas.You can open your notebooks on any device. You can enter text using the keyboard, write by hand, sketch and quickly find the notes you want (even handwritten). Make your notes more eloquent by adding tags, tables, and images. You can also share your notebook with others to collaborate on.

    How these applications differ from other versions

    Comparison of different versions of Excel

    Comparison of Word Features for Different Platforms

    Additional information

    Excel Mobile for Windows Help

    PowerPoint Mobile for Windows Help

    Word Mobile for Windows Help

    OneNote Help Topics

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    Supports iPhone SE, 6S, 6S Plus, 7, 7 Plus, 8, 8 Plus, X, XS, XR; iPad Mini 4, 5; iPad Air 2, 3; iPad Pro

    Call of Duty: Mobile does not support iPhone 5S, 6, 6 Plus; iPad Air, Mini 2, 3; iPod Touch ‘

    Official release of Call of Duty® specifically for phones.Play legendary maps in various modes anytime, anywhere. 100-player battle royale? A quick 5v5 team fight? Sniper duel? Free Call of Duty®: Mobile from Activision has it all.

    FREE ON MOBILE

    Awesome console quality game for your phone with custom controls, voice and text chat and incredible graphics and sound. Plunge into the world of the most popular shooter right now, on your phone anytime, anywhere.

    CULTURAL GAME MODES AND MAPS

    Play legendary maps from Call of Duty®: Black Ops and Call of Duty®: Modern Warfare®, free for the first time. Or team up with friends in the all-new

    survival mode in a 100-man battle royale. Join millions of players from all over the world!

    RICH EQUIPMENT

    As you participate in CALL OF DUTY®: MOBILE battles, you will gain access to a variety of characters, weapons, costumes, scores, and gear.All this you can add to your personal outfit. These sets can be used in battle royale, as well as exciting online modes, which include Team Battle, Frontline, Every Man, Search and Destroy, Domination and Stronghold.

    COMPETITIVE GAME AND COMMUNITY

    Prove your strategic superiority by storming the first lines of the ratings and win special clan prizes with your friends. Fight against millions of allies and opponents in our exciting online shooter.

    RIGHTS AND POSSIBILITIES OF CHOICE

    Call of Duty®: Mobile offers rich choice and depth in everything from gameplay and activities to controls and kits.

    Want to measure your strength with the best fighters? Download Call of Duty®: Mobile Now!

    _________________________________________________________

    NOTE: We’d love to hear from you about our game. To leave feedback, launch the game and select Settings> Feedback> Contact Us.To provide feedback, start the game and select Options> Feedback> Contact us.

    Subscribe and follow the news! —> profile.callofduty.com/cod/registerMobileGame

    _________________________________________________________

    Note: An internet connection is required to access this game.

    Keep in mind that the game contains social features that allow you to chat and play with friends, as well as a push notification system for interesting events and new content.You can enable or disable these features of your choice.

    © 2019 Activision Publishing, Inc. ACTIVISION and CALL OF DUTY are trademarks of Activision Publishing, Inc. All other trademarks and trade names are the property of their respective owners. By downloading, installing or using this Application, you agree to Activision’s privacy policies and terms of use as updated by Activision from time to time. The privacy policy is published at https: // www.activision.com/legal/privacy-policy and the terms of use are at https://www.activision.com/legal/terms-of-use.

    Choice of MOBIL oil for Volkswagen car

    Today, ExonnMobil manufactures a wide range of Mobil engine oils suitable for various Volkswagen vehicle models, including both gasoline and Volkswagen TDI diesel engine oils. For example, Mobil engine oils are produced, specially designed for Volkswagen Golf cars, such as the VW Golf 1.9 TDI as well as engine oils for Volkswagen Polo vehicles such as VW Polo 1.2 TSI.

    Oil Mobile for Volkswagen cars with VW 504 00 and VW 507 00 90 142 approvals

    Mobil 1 ESP Formula 5W-30 is a fully synthetic low ash oil approved by Volkswagen for gasoline vehicles requiring VW 504 00 approval and for VW diesel vehicles requiring a VW diesel engine. oils with VW 507 00 approval.

    Oil for Volkswagen cars with VW 502 00, VW 505 00 90 142 approvals

    Mobil 1 0W-40 is a fully synthetic oil approved by Volkswagen for its gasoline vehicles requiring VW 502 00 approved oils and for VW diesel vehicles requiring approval VW 505 00.

    Oil selection on the site allows you to choose the right one or another Mobile engine oil that is most suitable for the design of your VW car engine.The site contains various technical documentation for Mobil 1 engine oil, containing complete information on the various physical and chemical properties of engine oil for the engine of your Volkswagen car.

    How does Mobil 1 save money?

    Fully synthetic oils such as Mobil 1 are lighter than conventional mineral oils and provide better fluidity in your VW engine, allowing your vehicle to run more efficiently.In addition, Mobile 1 engine oil starts to work faster, the engine reaches its maximum efficiency earlier. Each of these benefits provides improved fuel efficiency, which translates into savings.

    How does Mobile Fully Synthetic Oil protect Volkswagen engines?

    Tests have shown that Mobil 1 engine oil can reach any friction point in the engine 15 seconds faster than conventional mineral oils.Before the engine oil can fully circulate, dry friction can occur between engine parts, which is inevitable and will significantly shorten engine life. Synthetic motor oils like Mobil 1 begin to circulate immediately, protecting every moving part at the friction points, resulting in reduced maintenance costs.

    How to choose the right engine oil for your VW car?

    It is important to use an original oil that meets the VW manufacturer’s specifications and approvals.In order not to violate the warranty conditions and to maintain the VW manufacturer’s warranty coverage, the correct Mobil 1 oil must be used, and the vehicle’s operating instructions must be followed. Recommendations for the use of one or another Mobile oil can be obtained using the appropriate oil selection software by searching for a specific make and model of a VW car engine.

    Use our oil selection functionality – this will allow you to get the right recommendations for choosing an original oil for your car.

    How to Add Another User for Authentication with IBKR Mobile – Android

    Overview:

    This article shows you how to add another user in the Authentication section of the IBKR Mobile app for Android devices.

    Requirements:

    • The Android device must have the IBKR Mobile app installed and IBKR Mobile authentication activated.
    • More information on installation and activation on Android devices is available in KB2270.

    Instructions:

    1. Open the IBKR Mobile app on your Android device.

    1.a. If after starting the application a login window opens ( fig. 1 ), click on Services (Services) in the upper left corner (marked with a red arrow) and go to step 2.

    1.b. If after launching the application, the main page, portfolio, watchlists or another page opens, click on the button More than in the upper left corner ( image 2 ). Select Two-Factor Authentication (Two-Factor Authentication) ( Image 3 ) and then Add User (Add User) ( Image 4 ) and go to Step 3.

    Fig. 1. Fig. 2. Fig. 3.

    Fig. 4.

    2. Select Authenticate (Authenticate) ( Img.5 ) and then Add User (Add User) ( Img.6 ).

    Fig. 5 Fig. 6.

    3. Read the instructions, then press Next (Continue) ( fig. 7 ).

    Fig. 7

    4. Enter your username and password and press Next (Continue) ( fig.8 ).

    Fig. 8.

    5. An SMS message with the code ( fig. 9) will be sent to your phone. Enter received code in the field activation code and press Send (Send) ( image 10 ).

    Fig. 9. Fig. 10.

    6.Enter your PIN code and press Activate (Activate) ( fig. 11 ).

    Fig. 11.

    7. Confirmation will be displayed upon successful authentication. Press to finish Done (Done) ( fig. 12 ).

    Fig. 12

    SAP introduced an updated version of SAP SuccessFactors Mobile for iOS

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    SAP SE announced an update to SAP SuccessFactors Mobile for iOS, which will be available in the Apple App Store later this month.Through the joint efforts of Apple and SAP developers, the updated iOS application will help modernize current HR processes, increase employee engagement and improve the overall efficiency of all solutions based on SAP SuccessFactors human capital management (HCM) for more than 47 million users worldwide.

    The mobile application was announced during the SuccessConnect conference, which took place June 12-14 in London.

    SAP SuccessFactors Mobile will improve business agility by providing instant access to HR services in SAP SuccessFactors HCM Suite and eliminating office outages delays.HR services can now take a completely new approach to work with employees, constantly maintaining and developing a lively and effective interaction. As a result, digital transformation of the workspace will lead to greater engagement and productivity of the entire team.

    “Brooks Brothers has a long history in the United States of America retail market and we pride ourselves on the people – our people, our customers and partners,” said Justin Watras , Director of Product Development. talent management and organizational performance Brooks Brothers.“We strive for global expansion and our talent strategy is also constantly transforming: we add new functionality to the system almost every quarter. Having the ability for management and employees to organize work processes remotely from various devices – whether it be accessing a company’s organizational chart, approving transactions, submitting any materials or feedback from production – ensured efficiency and increased our productivity. ”

    “Our employees must be able to work anywhere, anytime.For an electronics retailer looking to grow from 750,000 to 10 million products in the B2B market within two years, being able to remain an attractive employer in the region is critical. All SAP SuccessFactors solutions are mobile-friendly – they not only save time and empower users to get the job done, but they also involve people in the digitalization process, ”said Aleš Drábek, Chief Digital Officer at Conrad Electronic “.

    New version of SAP SuccessFactors Mobile has merged SAP Fiori with Apple iOS and includes performance management and overview, training certificates, history, task list, cataloged search, time tracking, pending requests and approvals, updated search engine and organizational chart, unified work space on iPhone and iPad.