Mrsa sinus infection symptoms. MRSA Sinus Infection: Symptoms, Causes, and Treatment Options
What are the symptoms of MRSA sinus infection. How is MRSA sinus infection diagnosed. What treatments are available for MRSA sinus infection. How can MRSA sinus infections be prevented.
Understanding Staphylococcus Aureus and MRSA
Staphylococcus aureus, commonly known as staph, is a bacterium that frequently colonizes the human body. While it’s often harmless, under certain conditions, it can cause infections ranging from minor skin issues to life-threatening diseases. Methicillin-resistant Staphylococcus aureus (MRSA) is a strain of staph that has developed resistance to many common antibiotics, making it particularly challenging to treat.
Is MRSA always harmful? Not necessarily. Many people carry MRSA on their skin or in their nasal passages without experiencing any symptoms or health issues. However, when MRSA enters the body through a cut, wound, or other means, it can cause serious infections, including sinus infections.
The Prevalence of Staph and MRSA
How common is staph colonization in humans? Studies suggest that between 20-80% of people carry Staphylococcus aureus in their nasal passages. This wide range reflects variations in populations and testing methods. The prevalence of MRSA is generally lower but has been increasing in recent years, particularly in healthcare settings and among certain at-risk populations.
MRSA Sinus Infection: Causes and Risk Factors
MRSA sinus infections occur when the MRSA bacteria enter the sinus cavities and cause inflammation and infection. Several factors can increase the risk of developing an MRSA sinus infection:
- Recent antibiotic use
- Prolonged hospital stays
- Weakened immune system
- Chronic sinus problems
- Nasal surgery or procedures
- Close contact with MRSA-positive individuals
Can nasal habits contribute to MRSA sinus infections? Yes, certain behaviors can increase the risk of introducing MRSA into the sinuses:
- Excessive nose picking
- Frequent nose blowing or rubbing
- Plucking or tweezing nasal hairs
These actions can create small abrasions or breaks in the skin, providing an entry point for MRSA bacteria.
Recognizing MRSA Sinus Infection Symptoms
The symptoms of an MRSA sinus infection can be similar to those of other types of sinus infections. However, MRSA infections may be more severe and resistant to standard treatments. Common symptoms include:
- Facial pain and pressure
- Nasal congestion and discharge
- Reduced sense of smell
- Headache
- Fever
- Fatigue
Are there any unique symptoms that might indicate an MRSA sinus infection? While not definitive, some signs that may suggest MRSA involvement include:
- Persistent or worsening symptoms despite standard antibiotic treatment
- Unusually severe pain or swelling
- Presence of boils or abscesses in or around the nose
- Rapid progression of symptoms
Potential Complications of Untreated MRSA Sinus Infections
If left untreated, MRSA sinus infections can lead to serious complications. These may include:
- Facial cellulitis: A bacterial infection of the deeper layers of skin
- Cavernous sinus thrombosis: A blood clot in the hollow space between the brain and eye sockets
- Osteomyelitis: Infection of the bones in the face or skull
- Meningitis: Inflammation of the protective membranes covering the brain and spinal cord
- Orbital cellulitis: Infection of the soft tissues surrounding the eye
How quickly can these complications develop? The progression of MRSA sinus infections can vary, but complications can develop rapidly in some cases, emphasizing the importance of prompt diagnosis and treatment.
Diagnosing MRSA Sinus Infections
Diagnosing an MRSA sinus infection typically involves a combination of clinical evaluation and laboratory tests. The process may include:
- Medical history review: The doctor will ask about symptoms, recent illnesses, and potential risk factors for MRSA.
- Physical examination: This includes examining the nose, sinuses, and surrounding areas for signs of infection.
- Nasal swab: A sample is taken from the inside of the nose to test for the presence of MRSA.
- Sinus culture: If possible, a sample of sinus drainage may be collected for culture and sensitivity testing.
- Imaging studies: CT scans or MRI may be used to assess the extent of the infection and rule out complications.
How long does it take to get MRSA test results? Rapid tests can provide preliminary results within hours, but confirmatory culture results typically take 24-48 hours.
Treatment Options for MRSA Sinus Infections
Treating MRSA sinus infections requires a targeted approach due to the bacteria’s resistance to many common antibiotics. Treatment options may include:
Antibiotic Therapy
The choice of antibiotics for MRSA sinus infections depends on the specific strain’s susceptibility pattern. Commonly used antibiotics include:
- Vancomycin
- Linezolid
- Daptomycin
- Trimethoprim-sulfamethoxazole
- Clindamycin
Is intravenous antibiotic treatment necessary for MRSA sinus infections? In severe cases or when oral antibiotics are ineffective, intravenous antibiotics may be required.
Topical Treatments
In addition to systemic antibiotics, topical treatments may be used to reduce MRSA colonization in the nose. These can include:
- Mupirocin ointment
- Chlorhexidine nasal gel
- Povidone-iodine nasal spray
Supportive Care
Supportive measures can help alleviate symptoms and promote healing:
- Saline nasal irrigation
- Over-the-counter pain relievers
- Warm compresses
- Adequate hydration
- Rest
Surgical Intervention
In some cases, surgical intervention may be necessary, particularly if abscesses have formed or if there are complications involving the surrounding structures.
How long does it take to treat an MRSA sinus infection? Treatment duration can vary but typically ranges from 7-14 days for uncomplicated cases, with longer courses necessary for severe or complicated infections.
Preventing MRSA Sinus Infections
Preventing MRSA sinus infections involves a combination of good hygiene practices and targeted strategies to reduce MRSA colonization. Key prevention measures include:
- Practicing good hand hygiene
- Avoiding touching your face, especially your nose, with unwashed hands
- Not sharing personal items like towels, razors, or nasal sprays
- Keeping your nasal passages moist with saline sprays or gels
- Managing underlying conditions that may increase your risk, such as allergies or chronic sinusitis
- Following your healthcare provider’s instructions if you’re known to be colonized with MRSA
Can probiotics help prevent MRSA sinus infections? While research is ongoing, some studies suggest that certain probiotics may help reduce MRSA colonization in the nasal passages. However, more evidence is needed before specific recommendations can be made.
Living with MRSA: Long-term Management and Considerations
For individuals who have experienced an MRSA sinus infection or who are colonized with MRSA, long-term management is crucial. This may involve:
- Regular follow-up with healthcare providers
- Periodic screening for MRSA colonization
- Decolonization protocols as recommended by your doctor
- Vigilant monitoring for signs of recurrent infection
- Education of family members and close contacts about MRSA prevention
Is it possible to completely eliminate MRSA colonization? While decolonization efforts can be successful, complete elimination of MRSA is challenging, and recolonization can occur. The goal is often to manage MRSA colonization and prevent active infections.
Psychological Impact of MRSA Infections
Living with MRSA can have psychological effects, including anxiety about potential infections or transmission to others. It’s important to address these concerns and seek support when needed. Healthcare providers can offer guidance on managing the emotional aspects of MRSA colonization or recurrent infections.
Emerging Research and Future Directions in MRSA Treatment
The field of MRSA research is rapidly evolving, with ongoing efforts to develop new treatment strategies and prevention methods. Some areas of current research include:
- Novel antibiotics effective against MRSA
- Bacteriophage therapy as an alternative to antibiotics
- Immunotherapies to boost the body’s natural defenses against MRSA
- Advanced diagnostic techniques for rapid MRSA detection
- Innovative approaches to biofilm disruption in chronic MRSA infections
What promising treatments are on the horizon for MRSA sinus infections? While still in early stages, researchers are exploring the use of nasal bacteriophage sprays and genetically engineered probiotics as potential treatments for MRSA nasal colonization and infection.
The Role of Antibiotic Stewardship
Antibiotic stewardship programs play a crucial role in combating antibiotic resistance, including MRSA. These initiatives aim to optimize antibiotic use, reduce unnecessary prescriptions, and slow the development of resistant bacteria. Healthcare providers and patients alike have a part to play in responsible antibiotic use.
How can patients contribute to antibiotic stewardship? Patients can help by not pressuring healthcare providers for antibiotics when they’re not necessary, completing prescribed antibiotic courses as directed, and never sharing or using leftover antibiotics.
Special Considerations for High-Risk Populations
Certain groups are at higher risk for MRSA infections, including sinus infections. These populations may require special attention and preventive measures:
- Healthcare workers
- Individuals with frequent hospitalizations
- People with chronic medical conditions
- Athletes in contact sports
- Military personnel
- Residents of long-term care facilities
What additional precautions should high-risk individuals take? High-risk individuals may benefit from regular MRSA screening, more aggressive decolonization protocols, and heightened vigilance for early signs of infection.
MRSA in the Community vs. Healthcare Settings
MRSA infections are often categorized as either community-associated (CA-MRSA) or healthcare-associated (HA-MRSA). While there is some overlap, these strains can differ in their characteristics and treatment approaches:
- CA-MRSA: Often causes skin and soft tissue infections, may be more virulent but potentially more susceptible to certain antibiotics
- HA-MRSA: More likely to cause invasive infections, often more resistant to multiple antibiotics
Do CA-MRSA and HA-MRSA require different treatment approaches for sinus infections? While the fundamental treatment principles are similar, the choice of antibiotics may differ based on the strain’s resistance pattern and the setting in which the infection was acquired.
The Global Impact of MRSA and Antibiotic Resistance
MRSA and other antibiotic-resistant infections represent a significant global health challenge. The World Health Organization (WHO) has identified antibiotic resistance as one of the biggest threats to global health, food security, and development.
Some key points regarding the global impact of MRSA include:
- Increased healthcare costs due to longer hospital stays and more expensive treatments
- Higher mortality rates for infections caused by resistant bacteria
- Challenges in treating common infections as antibiotics become less effective
- Economic impacts due to lost productivity and increased healthcare expenditures
What international efforts are underway to combat MRSA and antibiotic resistance? Global initiatives include surveillance programs to track resistant bacteria, research collaborations to develop new antibiotics, and education campaigns to promote appropriate antibiotic use.
The One Health Approach
The One Health approach recognizes that human health is closely connected to the health of animals and the environment. This concept is particularly relevant to antibiotic resistance and MRSA, as resistant bacteria can spread between humans, animals, and the environment.
How does the One Health approach apply to MRSA prevention? It emphasizes the need for coordinated efforts across human medicine, veterinary medicine, and environmental science to address MRSA and other resistant bacteria holistically.
Staph infection in nose: Symptoms, treatment, and diagnosis
A staphylococcus, or staph, infection is an infection caused by the bacteria Staphylococcus aureus.
Many people carry Staphylococcus aureus (S.aureus) on their skin or within their nose.
Here we look at the various causes and symptoms of a staph infection in the nose. We also outline the available treatment options for a nasal staph infection, as well as some tips for prevention.
Share on PinterestExcessively blowing or rubbing the nose is a possible cause of a staph infection in the nose.
The bacteria S. aureus cause staph infection.
Between 20–80% of humans carry S. aureus within their nasal passages. Most of the time, the bacteria do not cause any harm. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause an infection.
Damage to the surface of the skin may trigger a mild to a moderate staph infection. Damage to the deeper layers of the skin may trigger a severe or even life-threatening staph infection.
Staph bacteria are contagious and can spread to other people through:
- skin-to-skin contact
- sharing personal items, such as toothbrushes, razors, or washcloths
- coughing or sneezing, although these types of transmission are less common
A staph infection in the nose can occur as a result of a scratch, sore, or other types of damage to the skin of the nose.
Some potential causes of a nasal staph infection include:
- nose picking
- excessively blowing or rubbing the nose
- plucking or tweezing nasal hairs
A person who has a nasal staph infection may develop the following symptoms:
- redness and swelling of the nose
- crusting around the nostrils
- boils inside one or both nostrils
- facial swelling
- pain
- fever
In some cases, a staph infection may resolve by itself. In other cases, a person will require treatment to clear the infection and prevent further complications.
Some people may succeed in treating minor nasal infections at home. People can soothe sores and crusting by holding a clean, warm, damp cloth onto affected areas. It is important to wash the cloth afterward to avoid spreading the bacteria.
Some people may develop pus-filled boils inside the nostrils. A doctor will need to drain the boil in order to treat the infection and promote wound healing. This procedure typically involves the use of a local anesthetic.
If a nasal staph infection does not clear up by itself, a person may need to take oral antibiotics or apply topical antimicrobial treatments.
Without treatment, staph infections may recur. This is because S.aureus remains inside the nasal passages.
Prescription antibiotic treatments can reduce numbers of staph bacteria, thereby helping to prevent the staph infection from recurring.
Researchers have been investigating the best treatment to prevent recurrent staph infections. According to a 2015 review, topical antimicrobial medications may be more effective than oral antibiotics. This is because S. aureus may have a lower resistance to topical treatments.
Practicing good personal hygiene may also help to reduce the risk of repeat infections.
If a staph infection enters the bloodstream, it can cause serious complications. We list some potential complications below.
Facial cellulitis
Facial cellulitis is a bacterial infection affecting the deeper layers of the skin. Without treatment, the condition can be life-threatening.
Symptoms of facial cellulitis include:
- tenderness and pain in the face
- rash
- skin redness
- lockjaw
- a fever
- chills
- loss of appetite
Cavernous sinus thrombosis
A cavernous sinus thrombosis (CST) is a blood clot that forms in the cavernous sinuses. This is the hollow space between the brain and the eye sockets.
A CST can develop when an infection in the face or skull spreads to the cavernous sinuses. Although rare, the condition can be life-threatening.
Symptoms of a CST include:
- a fever
- a severe headache
- swelling around the eyes
- a weakness of the eye muscles, resulting in drooping eyelids, or double vision
- severe eye pain
Endocarditis
An infection can sometimes spread to the inner lining of the heart chambers and valves. The medical term for this is endocarditis.
Symptoms of endocarditis include:
- a fever
- chills
- fatigue
- aching muscles and joints
- difficulty breathing
- nausea and vomiting
- blood in the urine
Pneumonia
Pneumonia is the medical term for inflammation of one or both lungs. It typically occurs as a result of infection.
In pneumonia, the tiny air sacs, or alveoli, within the lungs fill with fluid or pus. This makes it difficult for a person to breathe.
Some common symptoms of pneumonia include:
- rapid or shallow breathing
- breathlessness, even when resting
- chest pain that worsens when breathing or coughing
- rapid heartbeat
- a fever
- chills
- feeling generally unwell
- loss of appetite
Sepsis
Sepsis is a potentially life-threatening condition in which the body’s immune system overreacts to an infection. This overreaction leads to a toxic build-up of chemicals within the blood.
Symptoms of sepsis include:
- rapid breathing
- increased heart rate
- a fever
- chills
- feeling confused or disorientated
Toxic shock syndrome
Toxic shock syndrome (TSS) is a rare condition in which staph bacteria release dangerous levels of toxins into the bloodstream. TSS can be life-threatening.
The symptoms of TSS come on suddenly and worsen rapidly. They include:
- a fever
- flu-like symptoms, such as a headache, body aches, and a sore throat
- nausea and vomiting
- diarrhea
- a widespread skin rash that appears similar to sunburn
- a bright red coloring of the lips, tongue, and eye-whites
- difficulty breathing
- fainting
- confusion
There are steps a person can take to reduce their risk of developing or spreading a staph infection of the nose or skin. These include:
- regularly washing hands with soap and clean water
- showering or bathing daily to keep skin clean
- covering any cuts or wounds with sterile bandaids or dressings
- avoiding sharing personal items, such as toothbrushes, razors, and washcloths
- covering the mouth and nose when coughing or sneezing
- disposing of tissues after blowing the nose
- avoiding picking the nose
- using only sterile equipment to pluck or tweeze nasal hair, or avoiding these practices altogether
Some staph infections may resolve by themselves, while others may require treatment.
People should see a doctor if the staph infection:
- is severe
- lasts longer than a week, or keeps coming back
- is getting worse, or spreading to other parts of the face
- causes a skin rash or redness
- causes fever or chills
- causes breathing difficulty, or a change in heart rate
Anyone who has a weakened immune system should see a doctor at the first sign of a staph infection. This includes people who:
- are elderly
- have an autoimmune disease
- are receiving chemotherapy
- have received an organ transplant
Staph bacteria commonly live inside the nose and are usually harmless. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause infection.
A person who has a nasal staph infection may develop redness, sores, or crusting around the nostrils. A person may need antibiotics or topical antimicrobial medications to treat the infection.
People should seek treatment if their infection is severe or persistent or accompanied by other symptoms. People who have a weakened immune system should seek treatment as soon as possible to reduce the risk of complications.
Staph infection in nose: Symptoms, treatment, and diagnosis
A staphylococcus, or staph, infection is an infection caused by the bacteria Staphylococcus aureus.
Many people carry Staphylococcus aureus (S.aureus) on their skin or within their nose.
Here we look at the various causes and symptoms of a staph infection in the nose. We also outline the available treatment options for a nasal staph infection, as well as some tips for prevention.
Share on PinterestExcessively blowing or rubbing the nose is a possible cause of a staph infection in the nose.
The bacteria S. aureus cause staph infection.
Between 20–80% of humans carry S. aureus within their nasal passages. Most of the time, the bacteria do not cause any harm. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause an infection.
Damage to the surface of the skin may trigger a mild to a moderate staph infection. Damage to the deeper layers of the skin may trigger a severe or even life-threatening staph infection.
Staph bacteria are contagious and can spread to other people through:
- skin-to-skin contact
- sharing personal items, such as toothbrushes, razors, or washcloths
- coughing or sneezing, although these types of transmission are less common
A staph infection in the nose can occur as a result of a scratch, sore, or other types of damage to the skin of the nose.
Some potential causes of a nasal staph infection include:
- nose picking
- excessively blowing or rubbing the nose
- plucking or tweezing nasal hairs
A person who has a nasal staph infection may develop the following symptoms:
- redness and swelling of the nose
- crusting around the nostrils
- boils inside one or both nostrils
- facial swelling
- pain
- fever
In some cases, a staph infection may resolve by itself. In other cases, a person will require treatment to clear the infection and prevent further complications.
Some people may succeed in treating minor nasal infections at home. People can soothe sores and crusting by holding a clean, warm, damp cloth onto affected areas. It is important to wash the cloth afterward to avoid spreading the bacteria.
Some people may develop pus-filled boils inside the nostrils. A doctor will need to drain the boil in order to treat the infection and promote wound healing. This procedure typically involves the use of a local anesthetic.
If a nasal staph infection does not clear up by itself, a person may need to take oral antibiotics or apply topical antimicrobial treatments.
Without treatment, staph infections may recur. This is because S.aureus remains inside the nasal passages.
Prescription antibiotic treatments can reduce numbers of staph bacteria, thereby helping to prevent the staph infection from recurring.
Researchers have been investigating the best treatment to prevent recurrent staph infections. According to a 2015 review, topical antimicrobial medications may be more effective than oral antibiotics. This is because S. aureus may have a lower resistance to topical treatments.
Practicing good personal hygiene may also help to reduce the risk of repeat infections.
If a staph infection enters the bloodstream, it can cause serious complications. We list some potential complications below.
Facial cellulitis
Facial cellulitis is a bacterial infection affecting the deeper layers of the skin. Without treatment, the condition can be life-threatening.
Symptoms of facial cellulitis include:
- tenderness and pain in the face
- rash
- skin redness
- lockjaw
- a fever
- chills
- loss of appetite
Cavernous sinus thrombosis
A cavernous sinus thrombosis (CST) is a blood clot that forms in the cavernous sinuses. This is the hollow space between the brain and the eye sockets.
A CST can develop when an infection in the face or skull spreads to the cavernous sinuses. Although rare, the condition can be life-threatening.
Symptoms of a CST include:
- a fever
- a severe headache
- swelling around the eyes
- a weakness of the eye muscles, resulting in drooping eyelids, or double vision
- severe eye pain
Endocarditis
An infection can sometimes spread to the inner lining of the heart chambers and valves. The medical term for this is endocarditis.
Symptoms of endocarditis include:
- a fever
- chills
- fatigue
- aching muscles and joints
- difficulty breathing
- nausea and vomiting
- blood in the urine
Pneumonia
Pneumonia is the medical term for inflammation of one or both lungs. It typically occurs as a result of infection.
In pneumonia, the tiny air sacs, or alveoli, within the lungs fill with fluid or pus. This makes it difficult for a person to breathe.
Some common symptoms of pneumonia include:
- rapid or shallow breathing
- breathlessness, even when resting
- chest pain that worsens when breathing or coughing
- rapid heartbeat
- a fever
- chills
- feeling generally unwell
- loss of appetite
Sepsis
Sepsis is a potentially life-threatening condition in which the body’s immune system overreacts to an infection. This overreaction leads to a toxic build-up of chemicals within the blood.
Symptoms of sepsis include:
- rapid breathing
- increased heart rate
- a fever
- chills
- feeling confused or disorientated
Toxic shock syndrome
Toxic shock syndrome (TSS) is a rare condition in which staph bacteria release dangerous levels of toxins into the bloodstream. TSS can be life-threatening.
The symptoms of TSS come on suddenly and worsen rapidly. They include:
- a fever
- flu-like symptoms, such as a headache, body aches, and a sore throat
- nausea and vomiting
- diarrhea
- a widespread skin rash that appears similar to sunburn
- a bright red coloring of the lips, tongue, and eye-whites
- difficulty breathing
- fainting
- confusion
There are steps a person can take to reduce their risk of developing or spreading a staph infection of the nose or skin. These include:
- regularly washing hands with soap and clean water
- showering or bathing daily to keep skin clean
- covering any cuts or wounds with sterile bandaids or dressings
- avoiding sharing personal items, such as toothbrushes, razors, and washcloths
- covering the mouth and nose when coughing or sneezing
- disposing of tissues after blowing the nose
- avoiding picking the nose
- using only sterile equipment to pluck or tweeze nasal hair, or avoiding these practices altogether
Some staph infections may resolve by themselves, while others may require treatment.
People should see a doctor if the staph infection:
- is severe
- lasts longer than a week, or keeps coming back
- is getting worse, or spreading to other parts of the face
- causes a skin rash or redness
- causes fever or chills
- causes breathing difficulty, or a change in heart rate
Anyone who has a weakened immune system should see a doctor at the first sign of a staph infection. This includes people who:
- are elderly
- have an autoimmune disease
- are receiving chemotherapy
- have received an organ transplant
Staph bacteria commonly live inside the nose and are usually harmless. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause infection.
A person who has a nasal staph infection may develop redness, sores, or crusting around the nostrils. A person may need antibiotics or topical antimicrobial medications to treat the infection.
People should seek treatment if their infection is severe or persistent or accompanied by other symptoms. People who have a weakened immune system should seek treatment as soon as possible to reduce the risk of complications.
Methicillin-resistant Staphylococcus aureus (MRSA) facts
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- MRSA facts
What is MRSA?
MRSA is an acronym for Methicillin-resistant Staphylococcus aureus , a bacterium that is resistant to certain antibiotics. Most MRSA infections cause skin conditions.
What are the symptoms of the disease?
Staphylococcal skin infections usually begin as breaks in the skin, through which bacteria enter the skin and develop into an infection. The set of symptoms includes:
- Local growth or irritation of the skin with characteristic redness, fever, swelling and pain. The affected area may be filled with pus or fluid.
- In some cases, infected individuals may experience fever or chills.
- Staphylococcal infections are often mistaken for bites from venomous arthropods.
How is the disease spread?
- MRSA infection is spread by close contact with the skin of infected individuals or by sharing objects that have been in direct contact with affected skin. Examples of objects that can be shared to spread staph infections include: towels, soap, dressings, bandages, sheets, clothing, sauna benches or hot tubs, and exercise equipment.
- Fluid or pus coming from the affected area is highly contagious.
- Some people carry MRSA in the nose or throat without experiencing symptoms; at the same time, such persons are included in the high-risk group as the most susceptible to infection.
How is MRSA diagnosed and treated?
- MRSA is usually diagnosed by swab analysis of the infected area. In the case of severe disease caused by MRSA infection, tests will help determine the antibiotic that will be effective in treating the infection.
- Treatment may also involve draining the abscess and cleaning the wound with or without antibiotics.
- Severe illness due to MRSA infection involves the use of antibiotics and, in some cases, hospitalization and surgery.
What are the ways to prevent MRSA?
- Keep cuts and scrapes clean and covered/covered.
- Avoid contact with wounds, bandages and dressings of others.
- Consult your physician immediately if you notice reddening of the wound, an increase in its temperature, or a worsening of its condition after treatment.
- Wash your hands regularly.
- Avoid sharing personal hygiene items such as razors.
- Shower after exercise and exercise.
- Last Updated February 14, 2018
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Methicillin-resistant Staphylococcus aureus of zoonotic origin – a new threat to public health | Vaganova
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