How is N-acetylcysteine inhalation used to treat respiratory conditions. What are the proper administration methods for N-acetylcysteine inhalation. What precautions should be taken when using N-acetylcysteine inhalation.

Understanding N-Acetylcysteine Inhalation Therapy

N-acetylcysteine inhalation is a powerful mucolytic agent used in the treatment of various respiratory conditions. This medication works by thinning mucus secretions in the airways, making it easier for patients to expel them and breathe more freely. It’s particularly beneficial for individuals suffering from chronic respiratory diseases such as asthma, emphysema, bronchitis, and cystic fibrosis.

The active ingredient, acetylcysteine, belongs to a class of medications known as mucolytic agents. Its primary function is to break down the molecular structure of thick, viscous mucus, transforming it into a more liquid state. This action facilitates easier expectoration and helps clear the airways, providing relief from chest congestion and improving overall respiratory function.

Indications and Therapeutic Applications

N-acetylcysteine inhalation therapy is prescribed for a variety of respiratory conditions characterized by excessive or abnormal mucus production. These include:

• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Emphysema
• Chronic bronchitis
• Cystic fibrosis
• Bronchiectasis

In these conditions, N-acetylcysteine helps to alleviate symptoms by reducing the viscosity of mucus, improving mucociliary clearance, and enhancing lung function. This can lead to better breathing, reduced coughing, and improved quality of life for patients struggling with chronic respiratory issues.

Can N-acetylcysteine inhalation be used for other medical purposes?

While primarily used for respiratory conditions, N-acetylcysteine has shown potential in other medical applications. One notable use is in the treatment of acetaminophen (Tylenol) overdose. In such cases, intravenous administration of N-acetylcysteine can help protect the liver from severe damage. However, this use is distinct from the inhalation therapy and should only be administered under close medical supervision in a hospital setting.

Proper Administration and Dosage Guidelines

N-acetylcysteine inhalation is typically administered using a nebulizer, a device that converts the liquid medication into a fine mist for inhalation. The standard dosing regimen usually involves using the medication three to four times daily, but this can vary based on individual patient needs and the specific condition being treated.

To ensure optimal therapeutic benefit and minimize potential side effects, it’s crucial to follow these administration guidelines:

1. Use the medication at approximately the same times each day to maintain consistent levels in the body.
2. Follow the prescription instructions carefully, and consult your healthcare provider or pharmacist if any part of the directions is unclear.
3. Do not alter the prescribed dosage or frequency without consulting your doctor.
4. When using the concentrated solution, mix it with normal saline or sterile water as directed, and use the prepared solution within one hour.
5. Be aware that there may be a slight unpleasant odor when using N-acetylcysteine, but this typically dissipates quickly.

What types of nebulizers are suitable for N-acetylcysteine administration?

N-acetylcysteine should only be used with nebulizers made of plastic or glass. It’s important to note that this medication should not be routinely used in hand-bulb operated nebulizers or placed directly into heated nebulizers. Always consult with your healthcare provider or pharmacist about the correct type of nebulizer to use with N-acetylcysteine to ensure safe and effective administration.

Potential Side Effects and Precautions

While N-acetylcysteine inhalation is generally well-tolerated, it can cause some side effects. Common side effects may include:

• Nausea
• Vomiting
• Fever
• Runny nose
• Swelling of the mouth’s interior
• Throat irritation
• Drowsiness
• Cool, moist skin

Most of these side effects are mild and tend to resolve on their own. However, if they persist or worsen, it’s important to consult your healthcare provider.

Are there any serious side effects associated with N-acetylcysteine inhalation?

While rare, some patients may experience more severe side effects that require immediate medical attention. These can include:

• Chest tightness
• Wheezing
• Difficulty breathing or swallowing
• Coughing up blood
• Hives
• Rash
• Severe itching

If you experience any of these symptoms, seek emergency medical care immediately. These could be signs of a serious allergic reaction or other severe complications.

Special Precautions and Considerations

Before starting N-acetylcysteine inhalation therapy, it’s crucial to inform your healthcare provider about your complete medical history, especially if you have:

• A history of asthma
• Any known allergies to medications
• Other ongoing medical conditions
• Pregnancy or plans to become pregnant
• Breastfeeding status

Additionally, provide a comprehensive list of all medications, supplements, and herbal products you’re currently taking. This information helps your healthcare provider assess potential drug interactions and determine the most appropriate treatment plan for your specific situation.

How should N-acetylcysteine be stored and handled?

Proper storage and handling of N-acetylcysteine are essential to maintain its effectiveness and safety. Store the medication at room temperature, away from heat, moisture, and direct light. Keep it out of reach of children and pets. If you notice any color changes in an opened bottle of N-acetylcysteine, such as a light purple hue, be aware that this is normal and does not affect the medication’s efficacy.

Maintenance and Cleaning of Nebulizer Equipment

Proper maintenance of your nebulizer is crucial for ensuring the effective delivery of N-acetylcysteine and preventing potential complications. Follow these guidelines for nebulizer care:

1. Clean your nebulizer immediately after each use to prevent medication residue from clogging the device.
2. Follow the manufacturer’s instructions for cleaning and disinfecting your specific nebulizer model.
3. Use sterile water or a mild soap solution for cleaning, and rinse thoroughly with sterile water.
4. Allow all components to air dry completely before reassembling the device.
5. Replace nebulizer parts as recommended by the manufacturer to maintain optimal performance.

Regular cleaning and maintenance not only ensure the proper functioning of your nebulizer but also help prevent the growth of harmful bacteria or mold that could potentially cause respiratory infections.

How often should nebulizer equipment be replaced?

The frequency of nebulizer replacement depends on the specific model and manufacturer recommendations. Generally, disposable nebulizer cups should be replaced every 2-4 weeks, while more durable components may last several months to a year. Always refer to your device’s user manual or consult with your healthcare provider for precise guidance on equipment replacement schedules.

Interactions with Other Medications and Substances

While N-acetylcysteine inhalation therapy is generally safe, it’s important to be aware of potential interactions with other medications or substances. Some key considerations include:

• Bronchodilators: N-acetylcysteine may enhance the effects of certain bronchodilators, potentially leading to increased bronchial secretions.
• Antibiotics: Some studies suggest that N-acetylcysteine might affect the absorption or efficacy of certain antibiotics when administered concurrently.
• Activated charcoal: If used for treating overdoses, activated charcoal may reduce the effectiveness of oral N-acetylcysteine.

Always inform your healthcare provider about all medications, supplements, and herbal products you’re using to avoid potential adverse interactions.

Can N-acetylcysteine be mixed with other inhaled medications?

In some cases, your healthcare provider may instruct you to mix N-acetylcysteine with other inhaled medications. However, this should only be done under specific guidance from your doctor. Improper mixing of medications can potentially reduce their effectiveness or cause adverse reactions. If you’re unsure about combining N-acetylcysteine with other inhaled treatments, always consult your healthcare provider or pharmacist for clarification.

Long-term Use and Monitoring

For patients with chronic respiratory conditions, long-term use of N-acetylcysteine inhalation therapy may be necessary. In such cases, regular monitoring by a healthcare provider is essential to assess the ongoing effectiveness of the treatment and detect any potential long-term side effects.

During follow-up appointments, your healthcare provider may:

• Evaluate your lung function through spirometry or other pulmonary function tests
• Assess your symptom control and quality of life
• Monitor for any adverse effects or complications
• Adjust the dosage or treatment plan as needed

Regular check-ups also provide an opportunity to address any concerns or questions you may have about your treatment regimen.

How long does it typically take to see improvements with N-acetylcysteine inhalation therapy?

The time frame for noticing improvements with N-acetylcysteine inhalation therapy can vary depending on the individual and the specific condition being treated. Some patients may experience relief from symptoms within a few days of starting treatment, while others might require several weeks of consistent use before noticing significant improvements. It’s important to continue using the medication as prescribed, even if you don’t immediately feel a difference. If you have concerns about the effectiveness of your treatment, discuss them with your healthcare provider rather than discontinuing the medication on your own.

Acetylcysteine Oral Inhalation: MedlinePlus Drug Information

pronounced as (a seet” il sis’ teen)

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Acetylcysteine inhalation is used along with other treatments to relieve chest congestion due to thick or abnormal mucous secretions in people with lung conditions including asthma, emphysema, bronchitis and cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction). Acetylcysteine is in a class of medications called mucolytic agents. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.

Acetylcysteine comes as a solution (liquid) and concentrated solution to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled). When using a nebulizer, it is usually used 3 to 4 times a day. When given by other methods, acetylcysteine should be used as directed. Use acetylcysteine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use acetylcysteine exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Only mix acetylcysteine with other medications if instructed to do so by your doctor.

The concentrated solution of acetylcysteine should be mixed with normal saline or sterile water and used within an hour.

There may be a slight unpleasant odor when you use acetylcysteine that goes away quickly. In an opened bottle of acetylcysteine, there may be a color change to a light purple, but it will not affect use.

Acetylcysteine should only be used with nebulizers made of plastic or glass. Acetylcysteine should not be routinely used in a hand bulb operated nebulizer or put directly into a heated nebulizer. Talk to your doctor or pharmacist about the correct nebulizer to use with acetylcysteine.

Clean your nebulizer immediately following each use. If you do not clean your nebulizer properly, the nebulizer may become clogged and may not allow medication to be inhaled. Follow the manufacturer’s directions carefully and ask your doctor or pharmacist if you have any questions about cleaning your nebulizer.

Acetylcysteine is also sometimes used to treat people who have taken or received an overdose of acetaminophen (Tylenol, others). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using acetylcysteine,

• tell your doctor and pharmacist if you are allergic to acetylcysteine, any other medications, or any of the ingredients in acetylcysteine inhalation. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have or have ever had asthma.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using acetylcysteine, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

Acetylcysteine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• vomiting
• fever
• runny nose
• swelling of the inside of the mouth
• throat irritation
• drowsiness
• cool, moist skin

Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:

• chest tightness
• wheezing
• difficulty breathing or swallowing
• coughing up blood
• hives
• rash
• itching

Acetylcysteine may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). After opening, keep this medication in the refrigerator, and dispose of any unused medication after 96 hours.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Mucomyst^®¶

• N-Acetylcysteine

^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 03/15/2017

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Acetylcysteine inhalation Uses, Side Effects & Warnings

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Generic name: acetylcysteine (inhalation) [ a-SEET-il-SIS-teen ]
Dosage form: inhalation solution (10%; 20%)
Drug classes: Antidotes, Mucolytics

Medically reviewed by Drugs. com on Nov 29, 2022. Written by Cerner Multum.

What is acetylcysteine inhalation?

Acetylcysteine inhalation is used to thin the mucus in people with certain lung conditions such as cystic fibrosis, emphysema, bronchitis, pneumonia, or tuberculosis. Acetylcysteine inhalation is also used during surgery or anesthesia, and to prepare the throat or lungs for a medical test.

Acetylcysteine inhalation may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use acetylcysteine if you are allergic to it.

Tell your doctor if you have asthma.

Tell your doctor if you are pregnant or breastfeeding.

How should I use acetylcysteine inhalation?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not use acetylcysteine inhalation at home if you do not fully understand all instructions that are specific to your use of acetylcysteine.

Acetylcysteine inhalation solution can be inhaled directly from the nebulizer or with a face mask, mouth piece, tent, or intermittent positive pressure breathing (IPPB) machine.

Use only the inhaler device provided with your medicine or you may not get the correct dose.

Do not place this medicine directly into a heated nebulizer medicine chamber.

Do not mix your dose of acetylcysteine inhalation until you are ready to use the medicine. Diluted acetylcysteine inhalation must be used within 1 hour of mixing.

Acetylcysteine inhalation liquid may change color once you have opened the bottle. This is caused by a chemical reaction and will not affect the medicine.

You may sense an unusual or unpleasant smell while using acetylcysteine inhalation. This effect should become less noticeable the longer you use the medicine.

Clean your nebulizer right after each use. The residue from acetylcysteine inhalation can clog the parts of the nebulizer.

Store an unopened vial (bottle) of acetylcysteine inhalation at room temperature, away from moisture and heat.

An opened acetylcysteine vial should be stored in a refrigerator, but you must use it within 96 hours (4 days) after opening. Do not allow the medicine to freeze.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using acetylcysteine inhalation?

Do not mix other medicines in a nebulizer with acetylcysteine inhalation, unless your doctor has told you to.

Acetylcysteine inhalation side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Acetylcysteine inhalation may cause serious side effects. Stop using acetylcysteine inhalation and call your doctor at once if you have:

Common side effects of acetylcysteine may include:

• sticky feeling around the nebulizer mask;

• white patches or sores inside your mouth or on your lips;

• nausea, vomiting;

• fever, runny nose, sore throat;

• drowsiness; or

• cold and clammy skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetylcysteine inhalation?

Other drugs may affect acetylcysteine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Fluimucil is a brand name for acetylcysteine sachets and tablets which may be used to clear phlegm and liquefy thick and viscous mucus secretions caused by respiratory conditions such as acute bronchitis, chronic bronchitis, cystic fibrosis, pneumonia, pulmonary emphysema, or bronchiectasis. It is a type of mucolytic. Fluimucil is available over the counter (without a prescription) in most countries that have it. Continue reading

NAC (N-acetyl cysteine) is a supplement that may be used to help people replenish glutathione – the most powerful antioxidant in the body. Levels of glutathione rapidly deplete during oxidative stress or after acetaminophen overdosage. NAC may also be used to help improve fertility, brain health, heart health, and long-term respiratory conditions (such as Asthma or COPD) and reduce the risk of developing certain cancers. In medicine, NAC has been used as an antidote to acetaminophen overdose since the 1960s and to treat those with acute liver failure. Continue reading

More about acetylcysteine

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• Reviews (31)
• Side effects
• Dosage information
• During pregnancy
• Drug class: antidotes
• Breastfeeding

Patient resources

• Drug Information
• Acetylcysteine (Inhalation) (Advanced Reading)
• Acetylcysteine (Intravenous) (Advanced Reading)
• Acetylcysteine (Oral) (Advanced Reading)
• Acetylcysteine Effervescent Tablets

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Professional resources

• Prescribing Information

Related treatment guides

• Acetaminophen Overdose
• Diagnostic Bronchograms
• Dietary Supplementation
• Expectoration

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01.

instructions for use, indications, composition

Per ampoule:
active substance: acetylcysteine ​​- 1000.0 mg;
excipients: disodium edetate, sodium hydroxide 2 M solution, water for injection.

Cough and cold remedies. Mucolytics.
ATS code: K05CB01.

Mucolytic agent. Liquefies sputum, increases its volume, facilitates sputum separation, promotes expectoration. The action of the drug is associated with the ability of free sulfhydryl groups of acetylcysteine ​​to break intra- and intermolecular disulfide bonds of sputum acid mucopolysaccharides, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity (in some cases this leads to a significant increase in sputum volume, which requires aspiration of bronchial contents). The drug remains active in the presence of purulent sputum.
It has an antioxidant effect due to the presence of the SH group, which is able to interact and neutralize electrophilic oxidative toxins. Acetylcysteine ​​promotes an increase in the synthesis of glutathione, which is an important antioxidant factor in intracellular protection and maintains the functional activity and morphological integrity of the cell.
Does not affect immunity. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates the mucous cells of the bronchi, the secret of which lyses fibrin. It has a similar effect on the secret formed in inflammatory diseases of the upper respiratory tract. Protects alpha1-antitrypsin (an elastase inhibitor) from the inactivating effect of HOCI, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has some anti-inflammatory action (by suppressing the formation of free
radicals and active oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Acute and chronic diseases of the respiratory system, accompanied by increased formation of a viscous secretion that is difficult to separate.

Adults: 3 ml 10% solution (300 mg acetylcysteine) 1-2 times a day.
Children (active participation age): 1.5 ml 10% solution (150 mg acetylcysteine) 1-2 times a day. Duration of treatment: 5-10 days.
For aerosol therapy of respiratory diseases, ultrasound devices and devices with a distribution valve can be used.
If the drug is well tolerated, the frequency of use and doses can be changed by the doctor, taking into account the clinical condition and therapeutic effect, without the need to differentiate doses for adults and children.

Acetylcysteine ​​ampoule is opened before use.
To obtain a 10% (100 mg/ml) solution, the initial 20% (200 mg/ml) solution of acetylcysteine ​​is diluted with water for injection in a ratio of 1:1. When diluted, the solution may acquire a violet-pink color.
The opened ampoule and ready-made solution for inhalation can be stored at a temperature of 2 ° C to 8 ° C for 24 hours (see section “Shelf life”).
When acetylcysteine ​​solution is mixed with bronchodilators or other drugs, it should be used as soon as possible and should not be stored.

Like all medicines, acetylcysteine ​​can cause side effects, although not everyone gets them.
Stop taking acetylcysteine ​​immediately and call your doctor if you experience any of the following side effects:
frequency unknown (frequency of occurrence cannot be determined from the available data): hypersensitivity reactions, bronchospasm, bronchial obstruction.
When using acetylcysteine, the following adverse reactions may also occur:
frequency unknown (based on the available data, the frequency of occurrence cannot be determined): rhinorrhea, stomatitis, nausea, vomiting, urticaria, rash, itching.
Adverse action report
If you experience side effects, tell your doctor. This also applies to any side effects not listed in this package insert. You can also report adverse reactions to the information base, data on adverse reactions (actions) to drugs, including reports of drug inefficiency, identified in the state (UE “Center for Expertise and Testing in Healthcare of the Ministry of Health of the Republic of Belarus”, rceth.by) . By reporting adverse reactions, you help to get more information about the safety of the drug.

– hypersensitivity to acetylcysteine ​​or other components of the drug;
– peptic ulcer of the stomach and duodenum in the acute stage;
– hemoptysis, pulmonary bleeding;
– pregnancy, lactation;
– children’s age up to 6 years.
With caution: gastric ulcer and duodenal ulcer in remission, esophageal varicose veins, bronchial asthma, adrenal disease, liver and / or kidney failure, arterial hypertension.

Symptoms: high doses of the drug can initiate the release of a large amount of bronchopulmonary secretion, which can lead to airway obstruction.
Treatment: mechanical removal of mucus from the tracheobroncheal tree.

The concomitant use of acetylcysteine ​​and antitussive drugs is not recommended. The simultaneous use of these drugs can lead, by inhibition of the cough reflex and physiological self-cleaning of the airways, to the accumulation of secretions with the risk of bronchospasm and upper respiratory tract infection.
The drug should be used with caution in patients with bronchial asthma. In the event of hypersensitivity reactions or bronchospasm, the drug should be stopped immediately and appropriate measures should be taken.
Acetylcysteine ​​should be used with caution in patients with a history of peptic ulcer, especially in the case of concomitant use of other drugs that irritate the gastric mucosa.
The use of acetylcysteine, mainly at the beginning of therapy, can dilute the secret of the bronchial glands and increase its volume. If the patient is unable to effectively cough up sputum, postural drainage and bronchial aspiration should be performed.
When working with the drug, it is necessary to use glassware, avoid contact with metals and rubber (the formation of sulfides with a characteristic odor is possible), easily oxidizing substances.
The faint sulfuric odor of the solution is the characteristic odor of the active substance. The use of acetylcysteine ​​may change the results of the quantitative determination of salicylates by the colorimetric method and the results of the determination of ketones in urine.

Pregnancy
Limited data on the use of the drug during pregnancy did not show an adverse effect on the course of pregnancy or on the health of the fetus or newborn. There is no experience of epidemiological studies.
Animal studies have not revealed direct or indirect toxic effects on pregnancy, embryonic development, fetal development and / or postnatal development. Use during pregnancy is contraindicated.
Lactation
Data on the intake of acetylcysteine ​​in breast milk are not available. Acetylcysteine ​​should not be used during breastfeeding.

There is no evidence of an effect on the reaction rate.

Interaction studies of acetylcysteine ​​with other drugs have only been performed in adults.
The simultaneous use of acetylcysteine ​​and antitussives can lead to the accumulation of bronchial secretions due to the suppression of the cough reflex, so the combined use of these drugs is not recommended.
It is also recommended to avoid the simultaneous use of mucolytics and other substances that inhibit secretion (for example, anticholinergics).
Acetylcysteine ​​can be used together with bronchodilators and vasoconstrictors.
There are literature data on the in vitro interaction of N-acetylcysteine ​​and a number of antibiotics, which indicate a decrease in the activity of antibiotics. In particular, due to the presence of a thiol group (-SH), N-acetylcysteine ​​can react chemically with various penicillins, tetracyclines, cephalosporins, aminoglycosides, macrolides and amphotericin B if these substances are mixed in the same solution. Therefore, as a precaution, it is not recommended to mix the solution of N-acetylcysteine ​​and antibiotics.
The combined use of acetylcysteine ​​and nitroglycerin may enhance the vasodilating and antiplatelet effects of the latter. If the combined use of nitroglycerin and N-acetylcysteine ​​is necessary, blood pressure should be monitored in patients. Patients should be warned about the possibility of lowering blood pressure, which can be severe and accompanied by headache.
Incompatible
Acetylcysteine ​​is incompatible with most metals and is inactivated by oxidizing agents. Therefore, if possible, devices with glass or plastic parts (but not rubber) should be used when using the drug.
If devices with metal or rubber parts are used, rinse immediately with water after use.
Acetylcysteine ​​should not be used in conjunction with other drugs, in particular antibiotics, in the same solution or in the same kit due to lack of compatibility data.

Store in a dark place at a temperature not exceeding 25 °C.
Keep out of the reach of children.

4 years.
Do not use after the expiry date stated on the package.
The opened ampoule and ready-made solution for inhalation can be stored at a temperature of 2 ° C to 8 ° C for 24 hours.

Clear, colorless solution with a characteristic odour. When opening the ampoules, the solution may acquire a violet-pink color.
5 ml glass ampoules. 10 ampoules, together with instructions for use, are placed in a cardboard box. 5 ampoules are placed in a blister pack made of polyvinyl chloride film and aluminum foil, 1 or 2 blister packs, together with instructions for use, are placed in a cardboard pack.

On prescription.

Manufacturer:
RUE “Belmedpreparaty”,
Republic of Belarus, 220007, Minsk, st. Fabritsiusa, 30, phone/fax: (+37517) 220 3716, e-mail: [email protected]

The use of N-acetylcysteine ​​in children: current data and new opportunities | Drones

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4. Chalumeau M., Duijvestijn Y.C. Acetylcysteine ​​and carbocysteine ​​for acute upper and lower respiratory tract infections in pediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst. Rev. 2013; (5): CD003124. DOI: 10.1002/14651858.CD003124.pub4.

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