Neck lymph node diagram. Comprehensive Guide to Head and Neck Lymph Nodes: Anatomy, Drainage, and Clinical Significance
What are the key lymph node levels in the head and neck region. How do these lymph nodes relate to various anatomical structures and potential pathologies. Why is understanding lymph node anatomy crucial for diagnosing and treating head and neck conditions.
Anatomy and Overview of Head and Neck Lymph Nodes
The head and neck region contains a complex network of over 300 lymph nodes and associated lymphatic channels. This intricate system plays a crucial role in immune function and can provide valuable diagnostic information in various pathological conditions. Understanding the anatomy and drainage patterns of these lymph nodes is essential for healthcare professionals involved in diagnosing and treating head and neck disorders.
The lymphatic system in this region is strongly lateralized, meaning that under normal circumstances, there is minimal direct communication between the left and right sides. Lymphatic drainage typically follows a path from the base of the skull down through the jugular chain, which runs alongside the internal jugular vein. From there, lymph can either flow into the spinal accessory chain near cranial nerve XI or proceed to the supraclavicular chain.
Ultimately, lymph drains into the venous system, but the exact pathway differs between the left and right sides of the body. On the left side, drainage occurs either directly into the jugulo-subclavian venous confluence or into the thoracic duct. On the right side, lymph typically empties into the right lymphatic duct.
Key Features of Head and Neck Lymphatic Drainage
- Over 300 lymph nodes present
- Strong lateralization with minimal crossover
- Drainage follows jugular, spinal accessory, and supraclavicular chains
- Different terminal drainage pathways for left and right sides
- Most structures drain ipsilaterally, with some midline exceptions
Are there structures that drain bilaterally? Yes, certain midline structures in the head and neck region can drain to lymph nodes on both sides of the body. These include:
- Nasopharynx
- Pharyngeal wall
- Base of the tongue
- Soft palate
- Larynx
Classification of Neck Lymph Node Levels
To facilitate precise communication and standardize clinical approaches, the lymph nodes of the neck are classified into specific levels. This system is crucial for describing the location of pathological findings, guiding surgical interventions, and planning radiotherapy treatments. The classification includes levels Ia, Ib, II, III, IV, V, VI, VII, VIII, IX, and X.
Level Ia: Submental Group
The submental lymph nodes are located in a triangular region known as the submental triangle. These nodes are bounded by the following structures:
- Superior: Symphysis menti (chin)
- Inferior: Hyoid bone
- Anterior: Platysma muscle
- Posterior: Mylohyoid muscles
- Lateral: Anterior belly of the digastric muscle (on each side)
- Medial: Virtual anatomic midline
What areas drain to the submental lymph nodes? The submental group receives lymphatic drainage from:
- Skin of the mental region (chin)
- Mid-lower lip
- Anterior portion of the oral tongue
- Floor of the mouth
In the context of malignancies, the submental nodes are most commonly associated with metastases from cancers originating in:
- Floor of the mouth
- Anterior oral tongue
- Mandibular alveolar ridge
- Lower lip
Level Ib: Submandibular Group
The submandibular lymph nodes occupy the submandibular triangle, which is defined by the following boundaries:
- Superior: Mylohyoid muscle
- Inferior: Hyoid bone
- Anterior: Symphysis menti
- Posterior: Posterior edge of the submandibular gland
- Lateral: Inner surface of the mandible
- Medial: Digastric muscle
What structures drain to the submandibular lymph nodes? This group receives lymphatic drainage from a wide range of areas, including:
- Efferent lymphatics from level Ia
- Lower nasal cavity
- Hard and soft palates
- Maxillary and mandibular alveolar ridges
- Skin and mucosa of the cheek
- Upper and lower lips
- Floor of the mouth
- Anterior oral tongue
In terms of malignancies, the submandibular nodes are commonly involved in metastases from:
- Oral cavity cancers
- Anterior nasal cavity tumors
- Soft tissue malignancies of the mid-face
- Submandibular gland cancers
The Upper Jugular Group: Level II Lymph Nodes
Level II lymph nodes mark the beginning of the jugular chain and are often referred to as the upper jugular group. These nodes play a critical role in the lymphatic drainage of various head and neck structures and are frequently involved in metastatic spread of malignancies in this region.
Anatomical Boundaries of Level II
The level II lymph nodes are located within specific anatomical boundaries:
- Superior: Base of the skull
- Inferior: Inferior border of the hyoid bone
- Anterior: Stylohyoid muscle
- Posterior: Posterior border of the sternocleidomastoid muscle
- Medial: Medial aspect of the internal carotid artery
It’s important to note that Level II is further subdivided into Level IIa and Level IIb, separated by the spinal accessory nerve.
Lymphatic Drainage to Level II
Which structures drain to the upper jugular lymph nodes? Level II receives lymphatic drainage from numerous areas, including:
- Oral cavity
- Nasal cavity
- Nasopharynx
- Oropharynx
- Larynx
- Parotid gland
- Submandibular gland
Are there specific malignancies associated with Level II node involvement? Yes, these nodes are commonly affected in cases of:
- Oral cavity cancers
- Oropharyngeal cancers
- Laryngeal cancers
- Nasopharyngeal carcinomas
- Salivary gland malignancies
Level III and IV: Middle and Lower Jugular Groups
Continuing down the jugular chain, we encounter the Level III and Level IV lymph nodes, also known as the middle and lower jugular groups, respectively. These nodes are crucial in the lymphatic drainage of the head and neck and are often involved in the metastatic spread of various malignancies.
Level III: Middle Jugular Group
The anatomical boundaries of Level III are as follows:
- Superior: Inferior border of the hyoid bone
- Inferior: Inferior border of the cricoid cartilage
- Anterior: Lateral border of the sternohyoid muscle
- Posterior: Posterior border of the sternocleidomastoid muscle
What areas drain to the Level III lymph nodes? These nodes receive lymphatic drainage from:
- Base of tongue
- Tonsils
- Larynx
- Hypopharynx
- Thyroid gland
Level IV: Lower Jugular Group
The Level IV lymph nodes are bounded by:
- Superior: Inferior border of the cricoid cartilage
- Inferior: Clavicle
- Anterior: Lateral border of the sternohyoid muscle
- Posterior: Posterior border of the sternocleidomastoid muscle
Which structures primarily drain to Level IV nodes? This group receives lymphatic drainage from:
- Hypopharynx
- Cervical esophagus
- Larynx
- Thyroid gland
Are there specific malignancies commonly associated with Level III and IV node involvement? Yes, these levels are frequently affected in cases of:
- Laryngeal cancers
- Hypopharyngeal cancers
- Thyroid cancers
- Advanced stage oral cavity and oropharyngeal cancers
Level V: Posterior Triangle Group
The Level V lymph nodes, also known as the posterior triangle group, are located in the posterior neck region. This level is further subdivided into Va and Vb, separated by a horizontal plane at the inferior border of the cricoid cartilage.
Anatomical Boundaries of Level V
The posterior triangle group is defined by the following boundaries:
- Superior: Junction of the sternocleidomastoid and trapezius muscles
- Inferior: Clavicle
- Anterior: Posterior border of the sternocleidomastoid muscle
- Posterior: Anterior border of the trapezius muscle
Lymphatic Drainage and Clinical Significance
What areas primarily drain to the Level V lymph nodes? These nodes receive lymphatic drainage from:
- Nasopharynx
- Oropharynx
- Skin of the posterior scalp and neck
In the context of malignancies, Level V nodes are often involved in:
- Nasopharyngeal carcinomas
- Oropharyngeal cancers
- Cutaneous malignancies of the posterior scalp and neck
- Thyroid cancers (particularly papillary thyroid carcinoma)
Level VI: Anterior Compartment Group
The Level VI lymph nodes, also referred to as the anterior compartment group, are located in the central region of the neck. These nodes are particularly important in the context of thyroid and laryngeal pathologies.
Anatomical Boundaries of Level VI
The anterior compartment group is defined by the following boundaries:
- Superior: Hyoid bone
- Inferior: Suprasternal notch
- Lateral: Medial borders of the carotid sheaths on both sides
Lymphatic Drainage and Clinical Significance
Which structures primarily drain to the Level VI lymph nodes? This group receives lymphatic drainage from:
- Thyroid gland
- Larynx
- Hypopharynx
- Cervical trachea
- Cervical esophagus
Are there specific malignancies commonly associated with Level VI node involvement? Yes, these nodes are frequently affected in cases of:
- Thyroid cancers (particularly papillary and medullary thyroid carcinomas)
- Laryngeal cancers
- Advanced hypopharyngeal cancers
- Subglottic laryngeal cancers
Clinical Importance of Lymph Node Knowledge in Head and Neck Pathologies
Understanding the anatomy and drainage patterns of head and neck lymph nodes is crucial for several reasons in clinical practice:
Diagnostic Significance
How does lymph node knowledge aid in diagnosis? A thorough understanding of lymph node anatomy allows clinicians to:
- Accurately localize pathological findings during physical examinations
- Interpret imaging studies more effectively
- Guide the selection of appropriate diagnostic procedures, such as fine-needle aspiration or biopsy
- Correlate lymph node involvement with potential primary sites of pathology
Staging of Malignancies
Why is lymph node status important in cancer staging? The presence and extent of lymph node metastases are critical factors in:
- Determining the stage of head and neck cancers
- Assessing prognosis
- Guiding treatment decisions
Surgical Planning
How does lymph node anatomy influence surgical approaches? Detailed knowledge of lymph node levels is essential for:
- Planning the extent of neck dissections in cancer surgery
- Ensuring complete removal of at-risk lymph node groups
- Preserving critical structures while achieving oncological goals
Radiation Therapy Planning
In what way does lymph node anatomy impact radiation treatment? Understanding lymph node levels is crucial for:
- Defining target volumes in radiation therapy planning
- Ensuring adequate coverage of at-risk nodal regions
- Minimizing radiation exposure to critical structures
Follow-up and Surveillance
How does lymph node knowledge aid in post-treatment care? Familiarity with lymph node anatomy is important for:
- Conducting thorough follow-up examinations
- Interpreting post-treatment imaging studies
- Early detection of regional recurrences
By mastering the intricacies of head and neck lymph node anatomy, healthcare professionals can significantly enhance their ability to diagnose, stage, treat, and monitor a wide range of head and neck pathologies, ultimately improving patient outcomes.
Anatomy, Head and Neck, Lymph Nodes – StatPearls
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Antony Koroulakis; Zohaib Jamal; Manuj Agarwal.
Author Information and Affiliations
Last Update: December 11, 2022.
Introduction
The head and neck, as a general anatomic region, is characterized by a large number of critical structures situated in a relatively small geographic area. It is inclusive of osseous, nervous, arterial, venous, muscular, and lymphatic structures. Lymphadenopathy is a significant clinical finding associated with acute infection, granulomatous disease, autoimmune disease, and malignancy. The involvement of specific nodal groups is an indicator of pathologically-affected organs and tissues, especially in the context of malignancy. As such, intimate knowledge of the anatomic relationships of the lymphatic nodal levels and the structures they drain is critical in the delivery of appropriate therapy in many patients with cancers of the head and neck. This knowledge is especially crucial in guiding the approach to proper locoregional therapy, whether by surgery or irradiation. A detailed understanding of the principle lymphatic nodal levels of the neck is required, including their anatomical configuration and boundaries, patterns of drainage, and risk of metastatic involvement in the context of malignancy.
Blood Supply and Lymphatics
The head and neck contains a rich and elaborate lymphatic network of more than 300 nodes and their intermediate channels. Aponeuroses bind them together with the muscles, nerves, and vessels of the head and neck. These lymphatic chains are strongly lateralized and typically do not directly communicate between left and right in the absence of a pathologic process. This lymphatic drainage originates at the base of the skull, then proceeds to the jugular chain adjacent to the internal jugular vein. From there it moves into the spinal accessory chain adjacent to the spinal accessory nerve, or cranial nerve XI, and then meets the supraclavicular chain. The lymphatics then drain on both sides. On the left side, they drain either directly into the vasculature via the jugulo-subclavian venous confluence or directly into the thoracic duct. On the right side, they flow directly into the lymphatic duct. Conversely, most structures drain ipsilaterally, except in the case of structures situated at the anatomic midlines. These include the nasopharynx, pharyngeal wall, base of the tongue, soft palate, and larynx. The lymph nodes of the neck are further classified by level. These levels are Ia, Ib, II, III, IV, V, VI, VII, VIII, IX, X. [1][2][3][4][5]
Level Ia: Submental Group
- Anatomy
Level I nodes are those bounded by the mandible superiorly and laterally and by the hyoid bone inferiorly. Level Ia contains the submental nodal group, bounded superiorly by the symphysis menti and inferiorly by the hyoid bone. It is bounded anteriorly by the platysma muscle, posteriorly by the mylohyoid muscles, laterally by the anterior belly of the digastric muscle, and medially by the virtual anatomic midline. These boundaries form a triangular region also termed the submental triangle.
- Drainage
This group drains the skin of the mental region, or chin, the mid-lower lip, the anterior portion of the oral tongue, and the floor of the mouth.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the floor of the mouth, anterior oral tongue, mandibular alveolar ridge, and lower lip.
Level Ib: Submandibular Group
- Anatomy
Level Ib contains the submandibular nodal group, bounded superiorly by the mylohyoid muscle and inferiorly by the hyoid bone. It is bounded anteriorly by the symphysis menti, posteriorly by the posterior edge of the submandibular gland, laterally by the inner surface of the mandible, and medially by the digastric muscle. These boundaries form a triangular region also termed the submandibular triangle.
- Drainage
They drain the efferent lymphatics from level Ia, the lower nasal cavity, both the hard and soft palates, and both maxillary and mandibular alveolar ridges. They also drain them from the skin and mucosa of the cheek, both upper and lower lips, the floor of the mouth, and the anterior oral tongue.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the oral cavity, anterior nasal cavity, soft-tissues of the mid-face, and submandibular gland.
Level II: Upper Jugular Group
- Anatomy
Level II represents the beginning of the jugular chain. It contains the upper jugular nodal group, adjacent to the top third of the internal jugular vein (IJV) and upper spinal accessory nerve. It is bounded superiorly by the insertion of the posterior belly of the digastric muscle into the mastoid process, and inferiorly by the caudal border of the hyoid bone or alternatively, as a surgical landmark, the carotid bifurcation. It is bounded anteriorly by the posterior edge of the submandibular gland, posteriorly by the posterior edge of the sternocleidomastoid muscle (SCM), laterally by the medial surface of the SCM, and medially by the internal carotid artery and scalenus muscle.
- Drainage
This group drains the efferent lymphatics of the face, parotid gland, level Ia, level Ib, and retropharyngeal nodes. It receives direct drainage from the nasal cavity, the entire pharyngeal axis, larynx, external auditory canal, middle ear, and the sublingual and submandibular glands.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasal and oral cavities, nasopharynx, oropharynx, hypopharynx, larynx, and major salivary glands. It is the most commonly involved nodal level. [6][7][8][9][10]
Level III: Middle Jugular Group
- Anatomy
Level III contains the middle jugular nodal group, adjacent to the middle third of the IJV. It is bounded superiorly by the caudal border of the hyoid bone, and inferiorly by the caudal edge of the cricoid cartilage or alternatively, as a surgical landmark, the plan where the omohyoid muscle crosses the IJV. It is also bounded anteriorly by the anterior edge of the SCM, or the posterior third of the thyrohyoid muscle, and posteriorly by the posterior border of the SCM. Finally, it is bordered laterally by the medial surface of the SCM, and medially by the internal carotid artery and scalenus muscle.
- Drainage
This group drains the efferent lymphatics from level II and level V, and partially from the retropharyngeal, pretracheal, and recurrent laryngeal nodes. It receives direct drainage from the base of the tongue, tonsils, larynx, hypopharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. [11][12][13][14][15]
Level IVa: Lower Jugular Group
- Anatomy
Level IVa contains the lower jugular nodal group adjacent to the inferior third of the IJV. It is bounded superiorly by the caudal border of the cricoid cartilage, and inferiorly by a virtual level two centimeters superior to the sternoclavicular joint, based off surgical conventions of level IVa dissection. It is bounded anteriorly by the anterior edge of the SCM (more superiorly) and the body of the SCM (more inferiorly), and posteriorly by the posterior edge of the SCM (more superiorly) and the SM(more inferiorly. This group is also laterally bound by the medial edge of the SCM (more superiorly) and the lateral edge of the SCM (more inferiorly). Finally, it is medially bordered by the medial edge of the common carotid artery, the medial edge of the thyroid gland and scalenus muscle (more superiorly), and the medial edge of the SCM (more inferiorly).
- Drainage
This group drains the efferent lymphatics from levels III and V, and partially from the retropharyngeal, pretracheal, and recurrent laryngeal nodes. It receives direct drainage from the larynx, hypopharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the hypopharynx, larynx, thyroid, cervical esophagus, and rarely, the anterior oral cavity. Deposits from the anterior oral cavity can manifest without proximal nodal involvement.
Level IVb: Medial Supraclavicular Group
- Anatomy
This nodal group is a continuation of level IVa to the superior edge of the sternal manubrium. It is bounded anteriorly by the deep surface of the SCM. Posteriorly, it is bound by the anterior edge of the scalenus muscle (more superiorly) and the lung apex, brachiocephalic vein, and artery on the right, as well as the common carotid and subclavian arteries on the left (more inferiorly). It is bounded laterally by the lateral edge of the scalenus muscle, and medially by the medial border of the common carotid artery which is also adjacent to level VI.
- Drainage
This group drains the efferent lymphatics from levels IVa and Vc, and partially from the pretracheal and recurrent laryngeal nodes. It receives direct drainage from the larynx, trachea, hypopharynx, esophagus, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the hypopharynx, subglottic larynx, trachea, thyroid, and cervical esophagus.
Level Va and Vb: Posterior Triangle Group
- Anatomy
These nodal groups are contained with the posterior triangle. They are situated posteriorly to the SCM, and adjacent to the inferior portion of the spinal accessory nerve and transverse cervical vessels. It is bounded superiorly by the superior edge of the hyoid bone and inferiorly by a virtual plane crossing the transverse vessels. It is bound anteriorly by the posterior margin of the SCM, and posteriorly by the anterior border of the trapezius muscle. It is also bound by the platysma muscle and skin laterally, and by the levator scapulae (more superiorly) and scalenus muscle (more inferiorly) medially. A virtual plane at the inferior edge of the cricoid cartilage divides this group into upper, or Va, and lower, or Vb, posterior triangles.
- Drainage
These nodal groups drain the efferent lymphatics from the occipital, retro-auricular, occipital, and parietal scalp nodes. It receives direct drainage from the skin of the lateral and posterior neck and shoulder, the nasopharynx, oropharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx, oropharynx, and thyroid.
Level Vc: Lateral Supraclavicular Group
- Anatomy
This nodal group is a continuation of levels Va and Vb; it contains the lateral supraclavicular group. It is bounded superiorly by a virtual plan crossing the transverse vessels, and inferiorly by a virtual plan 2 cm superior to the sternoclavicular join. It is also bounded anteriorly by the skin and posteriorly by the anterior border of the trapezius muscles (more superiorly) and the serratus anterior (more inferiorly). Laterally, it is bounded by the trapezius muscle (more superiorly) and the clavicle (more inferiorly). Medially, it is bordered by the scalenus muscle and lateral edge of the SCM, and is directly adjacent to the lateral edge of level IVa.
- Drainage
- Associated primary malignancies
Level VI: Anterior Compartment Group
The anterior compartment contains this nodal group, which is symmetric about the anatomic midline. It is also further subdivided into the superficially-located anterior jugular nodes, or level VIa, and the deeper pre-laryngeal, pre-tracheal, and para-tracheal (recurrent laryngeal) nodes, or level VIb. Level VIa
Level VIb
- Anatomy
Level VIb is bounded superiorly by the superior edge of the thyroid cartilage and inferiorly by the superior border of the sternal manubrium. It is also bounded anteriorly by the posterior margin of the infrahyoid muscles, and posteriorly by the anterior larynx, thyroid gland, and trachea at the midline, the pre-vertebral muscles on the right, and the esophagus on the left. This group is bordered laterally by the common carotid artery and medially by the lateral aspects of the trachea and esophagus.
- Drainage
Level VIb drains the efferent lymphatics from the anterior floor of the mouth, tip of the oral tongue, lower lip, thyroid gland, glottic and supraglottic larynx, hypopharynx, and cervical esophagus.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the lower lip, oral cavity (floor of the mouth and anterior oral tongue), thyroid, glottic and subglottic larynx, the apex of the piriform sinus, and the cervical esophagus. [16][17]
Level VII: Prevertebral Compartment Group, including Levels VIIa and VIIbLevel VIIa: Retropharyngeal Nodes
- Anatomy
These nodes are contained in the retropharyngeal space. They are divided into medial and lateral subgroups. The lateral groups are bounded superiorly by the superior edge of the C1 vertebral body, or the hard palate, and inferiorly by the superior edge of the body of the hyoid bone. Anteriorly, they are bounded by the posterior edge of the superior/middle pharyngeal constrictor muscles. They are bordered posteriorly by the longus capitis and longus colli muscles, laterally by the medial edge of the internal carotid artery, and medially by a virtual line parallel to the lateral edge of the longus capitis muscle. The medial groups are approximated at the midline and not well-defined.
- Drainage
These nodes drain the efferent lymphatics from the nasopharynx, eustachian tube, and soft palate.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx, pharyngeal wall, and oropharynx including tonsillar fossa and soft palate.
Level VIIb: Retrostyloid Nodes
- Anatomy
These nodes are contained in the fatty space surrounding the large vessels of the neck leading to the jugular foramen. They are the superior continuation of level II. Level VIIb is bounded superiorly by the jugular foramen at the base of skull, and inferiorly by the inferior edge of the lateral process of the C1 vertebral body, the superior boundary of level II. These nodes are bounded anteriorly by the posterior edge of the prestyloid parapharyngeal space, and posteriorly by the C1 vertebral body and base of skull. Finally, they are bordered laterally by the styloid process and deep parotid lobe, and medially by the medial edge of the internal carotid artery.
- Drainage
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx and anywhere in the head and neck resulting in significant infiltration of upper-level II nodes causing via retrograde flow.
Level VIII: Parotid Group
- Anatomy
This group includes the subcutaneous pre-auricular, superficial and deep intraparotid, and subparotid nodes. It is bounded superiorly by the zygomatic arch and external auditory canal, and inferiorly by the mandibular angle. This group is bounded anteriorly by the posterior edge of the mandibular ramus, the posterior edge of the masseter muscle (more laterally), and medial pterygoid muscle (medially). It is also bordered posteriorly by the anterior edge of the SCM (more laterally) and posterior belly of the digastric muscle (more medially). These nodes are bordered laterally by superficial muscular aponeurotic system (SMAS) layer within the subcutaneous tissues, and medially by the styloid process and muscle.
- Drainage
These nodes drain the efferent lymphatics from the frontal and temporal skin, eyelids, conjunctivae, auricles, external acoustic meatus, tympanum, nasal cavities, the root of the nose, nasopharynx, and the eustachian tube.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the previously named draining structures, as well as the orbit, external auditory canal, and parotid gland.[18]
Level IX: Buccofacial group
- Anatomy
This group contains the malar and the buccofacial nodes. These are superficial nodes surrounding the facial vessels on the external surface of the buccinator muscle. It is bounded superiorly by the inferior edge of the orbit and inferiorly by the inferior border of the mandible. It is also bounded anteriorly by the SMAS layer within the subcutaneous tissue, and posteriorly by the anterior edge of the masseter muscle and the corpus adiposum buccae. The lateral border is the SMAS layer, and the medial border is the buccinator muscle.
- Drainage
These nodes drain the efferent vessels of the nose, eyelids, and cheek.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the facial skin, nose, and buccal mucosa, as well as the maxillary sinus if invading soft tissues of the cheek.
Level X: Posterior Skull Group, including Levels Xa and Xb
Level Xa: Retroauricular and Subauricular Nodes
- Anatomy
This group includes superficial nodes on the mastoid process. It is bounded superiorly by the superior edge of the external auditory canal, and inferiorly by the mastoid tip. It is also bounded anteriorly by the anterior edge of the mastoid (inferiorly) and posterior edge of the external auditory canal (superiorly), and posteriorly by the posterior edge of the SCM. This group is bordered laterally by subcutaneous tissue, and medially by the splenius capitis muscles (inferiorly) and the temporal bone (superiorly).
- Drainage
These nodes drain the efferent vessels from the posterior auricular surface, external auditory canal, and adjacent scalp.
- Associated primary malignancies
Level Xb: Occipital Nodes
- Anatomy
This group is the superior and superficial continuation of level Va. It is bounded superiorly by the external occipital protuberance, and inferiorly by the superior border of level V. It is also bounded anteriorly by the posterior edge of the SCM, which is the posterior border of level Xa, and posteriorly by the anterior/lateral side of the trapezius muscle. Finally, this group is bordered laterally by subcutaneous tissues, and medially by the splenius capitis muscle.
- Drainage
- Associated primary malignancies
Clinical Significance
The lymphatic drainage of the head and neck is unique. Its remarkably well-delineated and characterized anatomic subgroups are closely associated with draining anatomic structure. These, in turn, are related to malignant neoplasms arising from specific anatomic structures. Intimate knowledge of this network allows the surgeon to complete an oncologically-appropriate dissection. It also helps the radiation oncologist appropriately treat elective nodal levels to reduce recurrence, and the primary care physician to guide the path to the necessary work up.
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Figure
Lymphatic System, Cervical lymph nodes, Lymphatics of the mammary gland, Cisterna chyli, Lumbar lymph nodes, Pelvic lymph nodes, Lymphatics of the lower limb, Thoracic duct, Thymus, Axillary lymph nodes, Spleen, Lymphatics of the upper limb, Inguinal (more…)
Figure
Lymph nodes of the neck; Posterior view, Afferent vessel to deep cervical glands, Afferent vessels of retropharyngeal glands, Retropharyngeal glands, Glandular nodule, Gland of deep cervical chain, Efferent vessels of retropharyngeal glands. Contributed (more…)
Figure
Lymph nodes of the arm, Deltoid pectoral glands, Axillary glands, Supratrochlear gland. Contributed by Gray’s anatomy Plates
Figure
Mediastinal lymph nodes. Image courtesy S Bhimji MD
Figure
Station for cervical lymph nodes. Contributed by Shekhar Gogna MD
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Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015 Jul;24(3):491-508. [PMC free article: PMC5018209] [PubMed: 25979396]
- 13.
Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, O’Leary M, Zitsch R, Siegel BA. Lymphatic drainage patterns in oral squamous cell carcinoma: findings of the ACOSOG Z0360 (Alliance) study. Otolaryngol Head Neck Surg. 2015 Apr;152(4):673-7. [PMC free article: PMC4399646] [PubMed: 25749001]
- 14.
Woolgar JA. Histological distribution of cervical lymph node metastases from intraoral/oropharyngeal squamous cell carcinomas. Br J Oral Maxillofac Surg. 1999 Jun;37(3):175-80. [PubMed: 10454023]
- 15.
Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg. 1990 Oct;160(4):405-9. [PubMed: 2221244]
- 16.
Chung EJ, Kim GW, Cho BK, Park HS, Rho YS. Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection. Head Neck. 2016 Apr;38 Suppl 1:E1969-73. [PubMed: 26835610]
- 17.
Chung EJ, Lee SH, Baek SH, Park IS, Cho SJ, Rho YS. Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 2014 Apr;124(4):882-7. [PubMed: 23832757]
- 18.
Chisholm EJ, Elmiyeh B, Dwivedi RC, Fisher C, Thway K, Kerawala C, Clarke PM, Rhys-Evans PH. Anatomic distribution of cervical lymph node spread in parotid carcinoma. Head Neck. 2011 Apr;33(4):513-5. [PubMed: 20652975]
Disclosure: Antony Koroulakis declares no relevant financial relationships with ineligible companies.
Disclosure: Zohaib Jamal declares no relevant financial relationships with ineligible companies.
Disclosure: Manuj Agarwal declares no relevant financial relationships with ineligible companies.
Copyright © 2023, StatPearls Publishing LLC.
This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4. 0 International (CC BY-NC-ND 4.0)
(
http://creativecommons.org/licenses/by-nc-nd/4.0/
), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
Bookshelf ID: NBK513317PMID: 30020689
Anatomy, Head and Neck, Lymph Nodes – StatPearls
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Introduction
The head and neck, as a general anatomic region, is characterized by a large number of critical structures situated in a relatively small geographic area. It is inclusive of osseous, nervous, arterial, venous, muscular, and lymphatic structures. Lymphadenopathy is a significant clinical finding associated with acute infection, granulomatous disease, autoimmune disease, and malignancy. The involvement of specific nodal groups is an indicator of pathologically-affected organs and tissues, especially in the context of malignancy. As such, intimate knowledge of the anatomic relationships of the lymphatic nodal levels and the structures they drain is critical in the delivery of appropriate therapy in many patients with cancers of the head and neck. This knowledge is especially crucial in guiding the approach to proper locoregional therapy, whether by surgery or irradiation. A detailed understanding of the principle lymphatic nodal levels of the neck is required, including their anatomical configuration and boundaries, patterns of drainage, and risk of metastatic involvement in the context of malignancy.
Blood Supply and Lymphatics
The head and neck contains a rich and elaborate lymphatic network of more than 300 nodes and their intermediate channels. Aponeuroses bind them together with the muscles, nerves, and vessels of the head and neck. These lymphatic chains are strongly lateralized and typically do not directly communicate between left and right in the absence of a pathologic process. This lymphatic drainage originates at the base of the skull, then proceeds to the jugular chain adjacent to the internal jugular vein. From there it moves into the spinal accessory chain adjacent to the spinal accessory nerve, or cranial nerve XI, and then meets the supraclavicular chain. The lymphatics then drain on both sides. On the left side, they drain either directly into the vasculature via the jugulo-subclavian venous confluence or directly into the thoracic duct. On the right side, they flow directly into the lymphatic duct. Conversely, most structures drain ipsilaterally, except in the case of structures situated at the anatomic midlines. These include the nasopharynx, pharyngeal wall, base of the tongue, soft palate, and larynx. The lymph nodes of the neck are further classified by level. These levels are Ia, Ib, II, III, IV, V, VI, VII, VIII, IX, X. [1][2][3][4][5]
Level Ia: Submental Group
- Anatomy
Level I nodes are those bounded by the mandible superiorly and laterally and by the hyoid bone inferiorly. Level Ia contains the submental nodal group, bounded superiorly by the symphysis menti and inferiorly by the hyoid bone. It is bounded anteriorly by the platysma muscle, posteriorly by the mylohyoid muscles, laterally by the anterior belly of the digastric muscle, and medially by the virtual anatomic midline. These boundaries form a triangular region also termed the submental triangle.
- Drainage
This group drains the skin of the mental region, or chin, the mid-lower lip, the anterior portion of the oral tongue, and the floor of the mouth.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the floor of the mouth, anterior oral tongue, mandibular alveolar ridge, and lower lip.
Level Ib: Submandibular Group
- Anatomy
Level Ib contains the submandibular nodal group, bounded superiorly by the mylohyoid muscle and inferiorly by the hyoid bone. It is bounded anteriorly by the symphysis menti, posteriorly by the posterior edge of the submandibular gland, laterally by the inner surface of the mandible, and medially by the digastric muscle. These boundaries form a triangular region also termed the submandibular triangle.
- Drainage
They drain the efferent lymphatics from level Ia, the lower nasal cavity, both the hard and soft palates, and both maxillary and mandibular alveolar ridges. They also drain them from the skin and mucosa of the cheek, both upper and lower lips, the floor of the mouth, and the anterior oral tongue.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the oral cavity, anterior nasal cavity, soft-tissues of the mid-face, and submandibular gland.
Level II: Upper Jugular Group
- Anatomy
Level II represents the beginning of the jugular chain. It contains the upper jugular nodal group, adjacent to the top third of the internal jugular vein (IJV) and upper spinal accessory nerve. It is bounded superiorly by the insertion of the posterior belly of the digastric muscle into the mastoid process, and inferiorly by the caudal border of the hyoid bone or alternatively, as a surgical landmark, the carotid bifurcation. It is bounded anteriorly by the posterior edge of the submandibular gland, posteriorly by the posterior edge of the sternocleidomastoid muscle (SCM), laterally by the medial surface of the SCM, and medially by the internal carotid artery and scalenus muscle.
- Drainage
This group drains the efferent lymphatics of the face, parotid gland, level Ia, level Ib, and retropharyngeal nodes. It receives direct drainage from the nasal cavity, the entire pharyngeal axis, larynx, external auditory canal, middle ear, and the sublingual and submandibular glands.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasal and oral cavities, nasopharynx, oropharynx, hypopharynx, larynx, and major salivary glands. It is the most commonly involved nodal level. [6][7][8][9][10]
Level III: Middle Jugular Group
- Anatomy
Level III contains the middle jugular nodal group, adjacent to the middle third of the IJV. It is bounded superiorly by the caudal border of the hyoid bone, and inferiorly by the caudal edge of the cricoid cartilage or alternatively, as a surgical landmark, the plan where the omohyoid muscle crosses the IJV. It is also bounded anteriorly by the anterior edge of the SCM, or the posterior third of the thyrohyoid muscle, and posteriorly by the posterior border of the SCM. Finally, it is bordered laterally by the medial surface of the SCM, and medially by the internal carotid artery and scalenus muscle.
- Drainage
This group drains the efferent lymphatics from level II and level V, and partially from the retropharyngeal, pretracheal, and recurrent laryngeal nodes. It receives direct drainage from the base of the tongue, tonsils, larynx, hypopharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. [11][12][13][14][15]
Level IVa: Lower Jugular Group
- Anatomy
Level IVa contains the lower jugular nodal group adjacent to the inferior third of the IJV. It is bounded superiorly by the caudal border of the cricoid cartilage, and inferiorly by a virtual level two centimeters superior to the sternoclavicular joint, based off surgical conventions of level IVa dissection. It is bounded anteriorly by the anterior edge of the SCM (more superiorly) and the body of the SCM (more inferiorly), and posteriorly by the posterior edge of the SCM (more superiorly) and the SM(more inferiorly. This group is also laterally bound by the medial edge of the SCM (more superiorly) and the lateral edge of the SCM (more inferiorly). Finally, it is medially bordered by the medial edge of the common carotid artery, the medial edge of the thyroid gland and scalenus muscle (more superiorly), and the medial edge of the SCM (more inferiorly).
- Drainage
This group drains the efferent lymphatics from levels III and V, and partially from the retropharyngeal, pretracheal, and recurrent laryngeal nodes. It receives direct drainage from the larynx, hypopharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the hypopharynx, larynx, thyroid, cervical esophagus, and rarely, the anterior oral cavity. Deposits from the anterior oral cavity can manifest without proximal nodal involvement.
Level IVb: Medial Supraclavicular Group
- Anatomy
This nodal group is a continuation of level IVa to the superior edge of the sternal manubrium. It is bounded anteriorly by the deep surface of the SCM. Posteriorly, it is bound by the anterior edge of the scalenus muscle (more superiorly) and the lung apex, brachiocephalic vein, and artery on the right, as well as the common carotid and subclavian arteries on the left (more inferiorly). It is bounded laterally by the lateral edge of the scalenus muscle, and medially by the medial border of the common carotid artery which is also adjacent to level VI.
- Drainage
This group drains the efferent lymphatics from levels IVa and Vc, and partially from the pretracheal and recurrent laryngeal nodes. It receives direct drainage from the larynx, trachea, hypopharynx, esophagus, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the hypopharynx, subglottic larynx, trachea, thyroid, and cervical esophagus.
Level Va and Vb: Posterior Triangle Group
- Anatomy
These nodal groups are contained with the posterior triangle. They are situated posteriorly to the SCM, and adjacent to the inferior portion of the spinal accessory nerve and transverse cervical vessels. It is bounded superiorly by the superior edge of the hyoid bone and inferiorly by a virtual plane crossing the transverse vessels. It is bound anteriorly by the posterior margin of the SCM, and posteriorly by the anterior border of the trapezius muscle. It is also bound by the platysma muscle and skin laterally, and by the levator scapulae (more superiorly) and scalenus muscle (more inferiorly) medially. A virtual plane at the inferior edge of the cricoid cartilage divides this group into upper, or Va, and lower, or Vb, posterior triangles.
- Drainage
These nodal groups drain the efferent lymphatics from the occipital, retro-auricular, occipital, and parietal scalp nodes. It receives direct drainage from the skin of the lateral and posterior neck and shoulder, the nasopharynx, oropharynx, and thyroid gland.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx, oropharynx, and thyroid.
Level Vc: Lateral Supraclavicular Group
- Anatomy
This nodal group is a continuation of levels Va and Vb; it contains the lateral supraclavicular group. It is bounded superiorly by a virtual plan crossing the transverse vessels, and inferiorly by a virtual plan 2 cm superior to the sternoclavicular join. It is also bounded anteriorly by the skin and posteriorly by the anterior border of the trapezius muscles (more superiorly) and the serratus anterior (more inferiorly). Laterally, it is bounded by the trapezius muscle (more superiorly) and the clavicle (more inferiorly). Medially, it is bordered by the scalenus muscle and lateral edge of the SCM, and is directly adjacent to the lateral edge of level IVa.
- Drainage
- Associated primary malignancies
Level VI: Anterior Compartment Group
The anterior compartment contains this nodal group, which is symmetric about the anatomic midline. It is also further subdivided into the superficially-located anterior jugular nodes, or level VIa, and the deeper pre-laryngeal, pre-tracheal, and para-tracheal (recurrent laryngeal) nodes, or level VIb. Level VIa
Level VIb
- Anatomy
Level VIb is bounded superiorly by the superior edge of the thyroid cartilage and inferiorly by the superior border of the sternal manubrium. It is also bounded anteriorly by the posterior margin of the infrahyoid muscles, and posteriorly by the anterior larynx, thyroid gland, and trachea at the midline, the pre-vertebral muscles on the right, and the esophagus on the left. This group is bordered laterally by the common carotid artery and medially by the lateral aspects of the trachea and esophagus.
- Drainage
Level VIb drains the efferent lymphatics from the anterior floor of the mouth, tip of the oral tongue, lower lip, thyroid gland, glottic and supraglottic larynx, hypopharynx, and cervical esophagus.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the lower lip, oral cavity (floor of the mouth and anterior oral tongue), thyroid, glottic and subglottic larynx, the apex of the piriform sinus, and the cervical esophagus. [16][17]
Level VII: Prevertebral Compartment Group, including Levels VIIa and VIIbLevel VIIa: Retropharyngeal Nodes
- Anatomy
These nodes are contained in the retropharyngeal space. They are divided into medial and lateral subgroups. The lateral groups are bounded superiorly by the superior edge of the C1 vertebral body, or the hard palate, and inferiorly by the superior edge of the body of the hyoid bone. Anteriorly, they are bounded by the posterior edge of the superior/middle pharyngeal constrictor muscles. They are bordered posteriorly by the longus capitis and longus colli muscles, laterally by the medial edge of the internal carotid artery, and medially by a virtual line parallel to the lateral edge of the longus capitis muscle. The medial groups are approximated at the midline and not well-defined.
- Drainage
These nodes drain the efferent lymphatics from the nasopharynx, eustachian tube, and soft palate.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx, pharyngeal wall, and oropharynx including tonsillar fossa and soft palate.
Level VIIb: Retrostyloid Nodes
- Anatomy
These nodes are contained in the fatty space surrounding the large vessels of the neck leading to the jugular foramen. They are the superior continuation of level II. Level VIIb is bounded superiorly by the jugular foramen at the base of skull, and inferiorly by the inferior edge of the lateral process of the C1 vertebral body, the superior boundary of level II. These nodes are bounded anteriorly by the posterior edge of the prestyloid parapharyngeal space, and posteriorly by the C1 vertebral body and base of skull. Finally, they are bordered laterally by the styloid process and deep parotid lobe, and medially by the medial edge of the internal carotid artery.
- Drainage
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the nasopharynx and anywhere in the head and neck resulting in significant infiltration of upper-level II nodes causing via retrograde flow.
Level VIII: Parotid Group
- Anatomy
This group includes the subcutaneous pre-auricular, superficial and deep intraparotid, and subparotid nodes. It is bounded superiorly by the zygomatic arch and external auditory canal, and inferiorly by the mandibular angle. This group is bounded anteriorly by the posterior edge of the mandibular ramus, the posterior edge of the masseter muscle (more laterally), and medial pterygoid muscle (medially). It is also bordered posteriorly by the anterior edge of the SCM (more laterally) and posterior belly of the digastric muscle (more medially). These nodes are bordered laterally by superficial muscular aponeurotic system (SMAS) layer within the subcutaneous tissues, and medially by the styloid process and muscle.
- Drainage
These nodes drain the efferent lymphatics from the frontal and temporal skin, eyelids, conjunctivae, auricles, external acoustic meatus, tympanum, nasal cavities, the root of the nose, nasopharynx, and the eustachian tube.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the previously named draining structures, as well as the orbit, external auditory canal, and parotid gland.[18]
Level IX: Buccofacial group
- Anatomy
This group contains the malar and the buccofacial nodes. These are superficial nodes surrounding the facial vessels on the external surface of the buccinator muscle. It is bounded superiorly by the inferior edge of the orbit and inferiorly by the inferior border of the mandible. It is also bounded anteriorly by the SMAS layer within the subcutaneous tissue, and posteriorly by the anterior edge of the masseter muscle and the corpus adiposum buccae. The lateral border is the SMAS layer, and the medial border is the buccinator muscle.
- Drainage
These nodes drain the efferent vessels of the nose, eyelids, and cheek.
- Associated primary malignancies
These nodes most often contain metastatic deposits from malignancies of the facial skin, nose, and buccal mucosa, as well as the maxillary sinus if invading soft tissues of the cheek.
Level X: Posterior Skull Group, including Levels Xa and Xb
Level Xa: Retroauricular and Subauricular Nodes
- Anatomy
This group includes superficial nodes on the mastoid process. It is bounded superiorly by the superior edge of the external auditory canal, and inferiorly by the mastoid tip. It is also bounded anteriorly by the anterior edge of the mastoid (inferiorly) and posterior edge of the external auditory canal (superiorly), and posteriorly by the posterior edge of the SCM. This group is bordered laterally by subcutaneous tissue, and medially by the splenius capitis muscles (inferiorly) and the temporal bone (superiorly).
- Drainage
These nodes drain the efferent vessels from the posterior auricular surface, external auditory canal, and adjacent scalp.
- Associated primary malignancies
Level Xb: Occipital Nodes
- Anatomy
This group is the superior and superficial continuation of level Va. It is bounded superiorly by the external occipital protuberance, and inferiorly by the superior border of level V. It is also bounded anteriorly by the posterior edge of the SCM, which is the posterior border of level Xa, and posteriorly by the anterior/lateral side of the trapezius muscle. Finally, this group is bordered laterally by subcutaneous tissues, and medially by the splenius capitis muscle.
- Drainage
- Associated primary malignancies
Clinical Significance
The lymphatic drainage of the head and neck is unique. Its remarkably well-delineated and characterized anatomic subgroups are closely associated with draining anatomic structure. These, in turn, are related to malignant neoplasms arising from specific anatomic structures. Intimate knowledge of this network allows the surgeon to complete an oncologically-appropriate dissection. It also helps the radiation oncologist appropriately treat elective nodal levels to reduce recurrence, and the primary care physician to guide the path to the necessary work up.
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Figure
Lymphatic System, Cervical lymph nodes, Lymphatics of the mammary gland, Cisterna chyli, Lumbar lymph nodes, Pelvic lymph nodes, Lymphatics of the lower limb, Thoracic duct, Thymus, Axillary lymph nodes, Spleen, Lymphatics of the upper limb, Inguinal (more. ..)
Figure
Lymph nodes of the neck; Posterior view, Afferent vessel to deep cervical glands, Afferent vessels of retropharyngeal glands, Retropharyngeal glands, Glandular nodule, Gland of deep cervical chain, Efferent vessels of retropharyngeal glands. Contributed (more…)
Figure
Lymph nodes of the arm, Deltoid pectoral glands, Axillary glands, Supratrochlear gland. Contributed by Gray’s anatomy Plates
Figure
Mediastinal lymph nodes. Image courtesy S Bhimji MD
Figure
Station for cervical lymph nodes. Contributed by Shekhar Gogna MD
References
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Chone CT, Crespo AN, Rezende AS, Carvalho DS, Altemani A. Neck lymph node metastases to the posterior triangle apex: evaluation of clinical and histopathological risk factors. Head Neck. 2000 Sep;22(6):564-71. [PubMed: 10941157]
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Vauterin TJ, Veness MJ, Morgan GJ, Poulsen MG, O’Brien CJ. Patterns of lymph node spread of cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2006 Sep;28(9):785-91. [PubMed: 16783833]
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Ishikawa M, Anzai Y. MR imaging of lymph nodes in the head and neck. Neuroimaging Clin N Am. 2004 Nov;14(4):679-94. [PubMed: 15489148]
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Ho FC, Tham IW, Earnest A, Lee KM, Lu JJ. Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer. 2012 Mar 21;12:98. [PMC free article: PMC3353248] [PubMed: 22433671]
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Candela FC, Kothari K, Shah JP. Patterns of cervical node metastases from squamous carcinoma of the oropharynx and hypopharynx. Head Neck. 1990 May-Jun;12(3):197-203. [PubMed: 2358329]
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Candela FC, Shah J, Jaques DP, Shah JP. Patterns of cervical node metastases from squamous carcinoma of the larynx. Arch Otolaryngol Head Neck Surg. 1990 Apr;116(4):432-5. [PubMed: 2317325]
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Hicks WL, Kollmorgen DR, Kuriakose MA, Orner J, Bakamjian VY, Winston J, Loree TR. Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg. 1999 Jul;121(1):57-61. [PubMed: 10388879]
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Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer. 1990 Jul 01;66(1):109-13. [PubMed: 2354399]
- 12.
Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015 Jul;24(3):491-508. [PMC free article: PMC5018209] [PubMed: 25979396]
- 13.
Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, O’Leary M, Zitsch R, Siegel BA. Lymphatic drainage patterns in oral squamous cell carcinoma: findings of the ACOSOG Z0360 (Alliance) study. Otolaryngol Head Neck Surg. 2015 Apr;152(4):673-7. [PMC free article: PMC4399646] [PubMed: 25749001]
- 14.
Woolgar JA. Histological distribution of cervical lymph node metastases from intraoral/oropharyngeal squamous cell carcinomas. Br J Oral Maxillofac Surg. 1999 Jun;37(3):175-80. [PubMed: 10454023]
- 15.
Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg. 1990 Oct;160(4):405-9. [PubMed: 2221244]
- 16.
Chung EJ, Kim GW, Cho BK, Park HS, Rho YS. Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection. Head Neck. 2016 Apr;38 Suppl 1:E1969-73. [PubMed: 26835610]
- 17.
Chung EJ, Lee SH, Baek SH, Park IS, Cho SJ, Rho YS. Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 2014 Apr;124(4):882-7. [PubMed: 23832757]
- 18.
Chisholm EJ, Elmiyeh B, Dwivedi RC, Fisher C, Thway K, Kerawala C, Clarke PM, Rhys-Evans PH. Anatomic distribution of cervical lymph node spread in parotid carcinoma. Head Neck. 2011 Apr;33(4):513-5. [PubMed: 20652975]
Disclosure: Antony Koroulakis declares no relevant financial relationships with ineligible companies.
Disclosure: Zohaib Jamal declares no relevant financial relationships with ineligible companies.
Disclosure: Manuj Agarwal declares no relevant financial relationships with ineligible companies.
Copyright © 2023, StatPearls Publishing LLC.
This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
(
http://creativecommons.org/licenses/by-nc-nd/4.0/
), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
Bookshelf ID: NBK513317PMID: 30020689
Lymph nodes : normal anatomy
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Literature
- Terminologia Anatomica: International Anatomical Terminology – FCAT Federative Committee On Anatomical Terminology, Federative Committee on Anatomical Terminology – Thieme, 1998 – ISBN 3131152516, 9783131152510
- Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Grégoire V, Coche E, Cosnard G, Hamoir M, Reychler H. Radiother Oncol. 2000 Aug;56(2):135-50. Review.PMID: 10927132
- CT-based definition of thoracic lymph node stations: an atlas from the University of Michigan.Chapet O, Kong FM, Quint LE, Chang AC, Ten Haken RK, Eisbruch A, Hayman JA.Int J Radiat Oncol Biol Phys. 2005 Sep 1;63(1):170-8.
- Definition of the supraclavicular and infraclavicular nodes: implications for three-dimensional CT-based conformal radiation therapy. Madu CN, Quint DJ, Normolle DP, Marsh RB, Wang EY, Pierce LJ. Radiology. 2001 Nov;221(2):333-9.
- Standardizing Neck Dissection Terminology: Official Report of the Academy’s Committee for Head and Neck Surgery and Oncology
K. Thomas Robbins; Jesus E. Medina; Gregory T. Wolfe; Paul A. Levine; Roy B. Sessions; Charles W. Pruet
Arch Otolaryngol Head Neck Surg. 1991;117(6):601-605.
anatomical structures
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Lymphadenitis of the face and neck / Lipetsk city dental clinic №1
What are the lymph nodes on the face and where are they located
Lymph nodes on the face act as a kind of lymph filters from toxic substances. This defensive reaction is especially important on the face. Location of lymph nodes:
Behind both auricles on the head On the neck under the ears slightly shifted forward Under the jaw from below Under the beard Under the eyes
Causes of inflammation of the facial lymph nodes
Facial lymph nodes play the role of “guards” of the body as a whole. And they are sensitive to the invasion of any infection or the beginning of an inflammatory process in the human body.
Inflammation of the lymph nodes on the face can be the result of such troubles as:
Infectious disease (cold, flu, rhinitis, sinusitis, tonsillitis) Tuberculosis Dental problems (periodontal disease, caries) Decreased immunity Skin diseases on the face Allergy Otitis Periodontitis
Inflammation of the lymph nodes on the face often occurs as a result of hypothermia.
Lymphadenitis of the facial node
Inflammation of the lymph nodes on the face indicates that there is an infection in the human body and red blood cells “rushed into battle.” And it is worth not only treating the lymph nodes on the face, but conducting a complete diagnosis of the state of health to detect the underlying problem.
The main cause of lymphadenitis of the facial nodes are skin diseases: acne, acne.
Location of lymph nodes
Lymphadenitis of the parotid and behind the ear nodes
Thickening of the lymph nodes on the face near the ears is a companion of inflammatory processes that occur in the ear or salivary gland, or diseases of the throat.
In children there is a thickening of the parotid and behind the ear nodes on the face with rubella, chicken pox. Such allergic reactions to vaccination are not uncommon. For a more accurate diagnosis, you should consult a surgeon.
Enlarged nodes in the lower part of the face
Lymph nodes in the lower part of the face can become inflamed for various reasons:
Dental problems (gum inflammation, caries) Sialoadenitis
With these diseases, there is an intensive removal of erythrocyte breakdown products from inflammation sites. Lymph nodes in the lower body do not have time to filter the lymph. This causes stagnation in the node and, as a result, its inflammation.
Facial lymphadenitis symptoms
Inflammation of the lymph nodes on the face occurs with prolonged stagnation of lymph in the node itself. Main symptoms:
Induration of the skin in this area Redness and itching Pain when pressed Increased body temperature
Cases of purulent inflammation of the lymph nodes on the face are not uncommon. With such a complication, pus accumulates in the node itself. The final recovery of the patient occurs after the extraction of purulent accumulations. It can rupture on its own or be removed with minor surgery.
Remember! Inflammatory processes of the lymph nodes on the face are not an entirely innocent disease. It can lead to serious complications:
Meningitis Encephalitis
It is strictly forbidden to self-treat inflammation of the lymph nodes on the face.
Types of lymphadenitis
Lymphadenitis of the facial nodes is:
Acute Chronic um Nonspecific lymphadenitis
The acute form of diseases of the lymph nodes on the face is characterized by the rapid onset of painful symptoms: the course of inflammation Indistinctly expressed localization of the focus “Fading” diseases for a long time Exacerbation when the immune system is weakened
Specific lymphadenitis on the face manifests itself as concomitant manifestations of such diseases as:
AIDS Syphilis Tuberculosis
Nonspecific lymphadenitis manifests itself after various infectious bacteria enter the lymph:
Streptococcus Staphylococcus Various toxins
If pus accumulates in the lymph node on the face, this is purulent lymphadenitis.
Diagnosis
As noted above, lymphadenitis is one of the body’s signals that inflammatory processes are occurring in the human body. And it is worth making a full diagnosis to find the root cause. After all, eliminating the symptoms does not get rid of the main problem.
During the examination, the doctor pays special attention to the location of the inflamed lymph nodes. If they are near the ear, this may indicate otitis media. Purulent inflammation of the node on the face is most often the result of subcutaneous abscesses.
Purulent, inflamed lymph nodes on the face in most cases are treated with surgery. But it is not uncommon that the abscess is torn. It is very good if the content comes out. It happens that pus gets inside. Then surgery is simply a must with a more thorough approach. Need general anesthesia and a long process of cleaning the affected area of the face.
Prevention
It is quite easy to avoid inflammation in the lymph node:
Follow the strengthening of the immune system.