Nystatin clotrimazole or miconazole: A comparison between the effects of nystatin, clotrimazole and miconazole on vaginal candidiasis

09.02.202120.07.2023 by alexxlab

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Miconazole Topical vs Nystatin Topical Comparison

Miconazole Topical vs Nystatin Topical Comparison – Drugs.com
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May also be prescribed off label for Balanoposthitis. ”>
Prescription and OTC

Prescribed for Vaginal Yeast Infection, Cutaneous Candidiasis, Oral Thrush, Tinea Cruris, Tinea Pedis, Tinea Versicolor, Intertrigo, Tinea Corporis. May also be prescribed off label for Balanoposthitis.
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nystatin topical may also be used for purposes not listed in this comparison guide. ”>
Prescription only

Prescribed for Cutaneous Candidiasis, Vaginal Yeast Infection, Paronychia. nystatin topical may also be used for purposes not listed in this medication guide.

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Clotrimazole Topical vs Nystatin Topical Comparison

Clotrimazole Topical vs Nystatin Topical Comparison – Drugs.com
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View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.

May also be prescribed off label for Balanoposthitis. ”>
Prescription and OTC

Prescribed for Cutaneous Candidiasis, Intertrigo, Vaginal Yeast Infection, Tinea Corporis, Tinea Pedis, Paronychia, Tinea Cruris, Tinea Versicolor. May also be prescribed off label for Balanoposthitis.
View more

nystatin topical may also be used for purposes not listed in this comparison guide. ”>
Prescription only

Prescribed for Cutaneous Candidiasis, Vaginal Yeast Infection, Paronychia. nystatin topical may also be used for purposes not listed in this medication guide.

Related suggestions

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Fluconazole
Diflucan
Gyne-Lotrimin
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Which drug to choose: nystatin or clotrimazole?

Nystatin or clotrimazole: which drug to choose for the treatment of fungal infections? Learn about the benefits and uses of each to help you make the right choice.

Fungal infections are one of the most common problems in the field of dermatology. Often people experience such unpleasant symptoms as itching, redness and peeling of the skin. Various drugs are widely used to treat fungal infections, some of which are nystatin and clotrimazole.

Nystatin is an antifungal drug that is effective against Candida. It is used to treat fungal infections of the skin, mucous membranes and internal organs. Nystatin is available in various forms: ointment, cream, mouthwash. It has a high degree of safety and is well tolerated by patients.

Clotrimazole is another antifungal drug that is widely used to treat fungal infections of the skin and mucous membranes. It is effective against most types of fungi, including Candida. Clotrimazole is available as a cream, ointment, or solution. It is well absorbed into the skin and has a quick healing effect.

The choice between nystatin and clotrimazole depends on the individual situation and the doctor’s advice. Nystatin is usually recommended for the treatment of Candida infections, especially in the oral area. Clotrimazole is usually recommended for the treatment of infections of the skin and mucous membranes caused by various types of fungi. In any case, before using any drug, you should consult your doctor.

Nystatin or clotrimazole: which drug should I choose?

When choosing between nystatin and clotrimazole, it is important to consider the characteristics of each drug and the nature of the disease. Nystatin and clotrimazole are antifungal drugs, but act differently on pathogenic fungi.

Nystatin is widely used in the treatment of candidiasis caused by Candida albicans. It inhibits the growth and reproduction of fungi, which helps to eliminate the symptoms of the disease, such as itching, burning, and discharge. Nystatin is usually applied as a topical treatment in the form of a cream, ointment, or mouthwash.

Clotrimazole is also effective against Candida albicans as well as other fungi such as Trichophyton and Epidermophyton. It penetrates into the cells of fungi and breaks their membrane, which leads to their death. Clotrimazole is available in various forms including cream, ointment, solution, suppositories, and tablets.

When choosing between nystatin and clotrimazole, it is important to consider the site of the lesion and the severity of the disease. For example, nystatin may be preferred for treating oral candidiasis, and clotrimazole for treating fungal infections of the skin or nails. In some cases, a doctor may recommend a combination treatment using both drugs.

It is important to remember that nystatin and clotrimazole are drugs and should only be used as directed by a physician. If you have any doubts or side effects, you should contact a specialist for advice and recommendations.

Nystatin versus clotrimazole

Nystatin and clotrimazole are two drugs that are widely used to treat fungal infections. They have different mechanisms of action and methods of application, which affects their effectiveness and choice depending on the specific situation.

Nystatin is an antifungal drug that works by inhibiting the growth and reproduction of fungi. It is mainly used to treat candidiasis, including thrush and fungal infections of the mouth. Nystatin is available in various forms, including ointment, capsules, and suspension. It has low toxicity and is well tolerated by most patients.

Clotrimazole is also an antifungal drug, but its mode of action is different from that of nystatin. It acts on fungal cells, damaging their membranes and preventing their reproduction. Clotrimazole is used to treat various fungal infections of the skin, nails and mucous membranes. It is available as a cream, ointment, solution, and tablets.

The effectiveness of nystatin and clotrimazole may vary depending on the type of fungal infection and its location. For example, nystatin may be more effective in treating oral candidiasis because it has antifungal activity at the contact surface. However, clotrimazole may be preferable for the treatment of fungal infections of the skin and nails, as it has a broader spectrum of action and can penetrate deeper into tissues.

In general, the choice between nystatin and clotrimazole should be based on the advice of the physician, the type and location of the fungal infection, and the individual patient. It is important to follow the recommendations for dosage and duration of treatment to achieve the best results and prevent relapses.

Differences in formulations

Nystatin and clotrimazole are two different drugs used to treat fungal infections of the skin and mucous membranes. They have a different composition, which determines their different mechanisms of action and range of applications.

Nystatin is an antifungal drug whose main active ingredient is nystatin. This antimicrobial drug prevents the reproduction of fungi, inhibiting their growth and development. Nystatin acts on the cell membranes of fungi, damaging their structure and preventing the normal functioning of fungal cells.

Clotrimazole, in turn, contains the active ingredient clotrimazole. This antifungal drug has a wide spectrum of action and is effective against various types of fungi. Clotrimazole acts by inhibiting the synthesis of ergosterol, which is an important component of fungal cell membranes. This leads to damage to the structure of fungal cells and their death.

Thus, nystatin and clotrimazole have different active components and mechanisms of action, which determines their different properties and effectiveness in the treatment of fungal infections. When choosing a drug, it is necessary to take into account the characteristics of the disease and the recommendations of the doctor.

Spectrum of action of nystatin and clotrimazole

Nystatin and clotrimazole are two antimycotic drugs that are often used to treat fungal infections. However, they have a different spectrum of action and can be effective in different cases.

Nystatin is a polyene antibiotic that is active against various types of fungi, including Candida albicans. It is highly effective against fungal infections of the skin, mucous membranes of the mouth, gastrointestinal tract and vagina. Nystatin works by destroying the cell membranes of fungi, which leads to their death.

Clotrimazole is an imidazole antimycotic that is also effective against various fungal species, including Candida albicans. However, it can also be used to treat infections caused by dermatophytes and yeasts. Clotrimazole inhibits the growth of fungi by blocking their ability to produce ergosterol, an important component of fungal cell membranes.

In general, nystatin and clotrimazole have a broad spectrum of activity against fungal infections. However, when choosing between them, it is important to take into account the specific disease and its localization. For example, nystatin is often used to treat infections of the oral mucosa, while clotrimazole may be more effective for fungal infections of the skin and nails.

Advantages of nystatin over clotrimazole

1. Wider spectrum of action. Nystatin is an antifungal drug that is effective against most types of fungal infections, including Candida spp. and other fungi that cause diseases of the skin and mucous membranes.

2. Less likely to develop resistance. Nystatin acts by penetrating the cell membranes of fungi and disrupting their structure. This reduces the likelihood of developing resistance to the drug, in contrast to clotrimazole, which can cause the development of resistant strains of fungi.

3. Fewer side effects. Nystatin is poorly absorbed into the systemic circulation and therefore has minimal systemic effects. This avoids many side effects associated with exposure to organs and body systems. Unlike nystatin, clotrimazole can cause skin irritation and dryness, burning and redness, which can be unpleasant for the patient.

4. Safe for use in pregnant and lactating women. Nystatin has no toxic properties and can be used to treat fungal infections in pregnant and lactating women without risk to the development of the fetus or child.

5. Availability and low cost. Nystatin is one of the most affordable and affordable antifungals on the market. This makes it the preferred choice for patients with limited financial means.

Advantages of clotrimazole over nystatin

Clotrimazole is a drug that has several advantages over nystatin in the treatment of fungal infections.

First, clotrimazole has a broad spectrum of activity, which makes it suitable for the treatment of various types of fungal infections, including candidal infections. Nystatin, in turn, has limited activity and is not always effective against all types of fungi.

Secondly, clotrimazole is highly effective and has a fast onset of action. It is able to quickly destroy fungi and eliminate the symptoms of infection. Nystatin, on the other hand, requires longer use to achieve the same effect.

In addition, clotrimazole is available in various forms such as creams, ointments and solutions, making it easy to apply to different areas of the body. Nystatin is most often available only in the form of a cream or ointment.

It is also worth noting that clotrimazole has fewer side effects than nystatin. This makes it safer for long-term use and allows it to be used even if there are certain contraindications.

In general, clotrimazole is the preferred choice in the treatment of fungal infections due to its broad potency, rapid action, variety of formulations, and fewer side effects.

Side effects of nystatin and clotrimazole

Nystatin:

Allergic reactions: possible skin rashes, itching, redness, swelling;
Discomfort: some patients may experience discomfort, burning or heat at the site of application of the drug;
Dry skin: Nystatin can cause dry skin, so moisturizers are recommended;
Local irritations: in rare cases, redness, peeling or irritation may occur at the site of application of the drug;
Indigestion: some patients may experience nausea, vomiting, or diarrhea after taking nystatin.

Clotrimazole:

Allergic reactions: possible skin rashes, itching, redness, swelling;
Skin burns: some patients may experience a burning sensation or burns at the site of application of the drug;
Local irritations: in rare cases, redness, peeling or irritation may occur at the site of application of the drug;
Dry skin: clotrimazole may cause dry skin, so moisturizers are recommended;
Vaginal burning: Some patients may experience vaginal burning or discomfort after using clotrimazole.

It should be noted that side effects may be different for each patient. If you experience any discomfort or reaction after using nystatin or clotrimazole, it is recommended that you consult your doctor or pharmacist.

Which drug to choose for certain symptoms

In the presence of symptoms of fungal infections of the skin and mucous membranes, it is important to choose the appropriate drug for effective treatment. The two most common drugs for the treatment of fungal infections – nystatin and clotrimazole – have their own characteristics and are recommended depending on the symptoms and the site of the lesion.

Nystatin is widely used to treat fungal infections of the skin and mucous membranes caused by Candida. The drug is available in various forms: ointment, cream, tablets, suspension. Nystatin has an antifungal effect and is effective in superficial infections of the skin and mucous membranes. It can be used to treat thrush, yeast dermatitis, and other fungal infections.

Clotrimazole is also an antifungal drug that can be used to treat fungal infections of the skin and mucous membranes. It is available in various forms: cream, ointment, solution. Clotrimazole is effective in the treatment of foot fungus, thrush and other fungal infections. It has a wide spectrum of activity and can be used to treat various types of fungal infections.

When choosing between nystatin and clotrimazole, it is important to consider the location of the lesion and the nature of the symptoms. For example, nystatin may be preferred in the treatment of fungal infections of the mucous membranes, such as thrush, while clotrimazole may be more effective in the treatment of fungal infections of the skin, such as foot fungus. It is important to consult your doctor or pharmacist to choose the most appropriate drug and dosage for your particular case.

Q&A:

Which drug is more effective: nystatin or clotrimazole?

Both drugs are effective in treating fungal infections, but the choice depends on the type of infection and the individual patient. Nystatin is commonly used to treat candidiasis, while clotrimazole can be used for various fungal infections of the skin and mucous membranes.

Which drug helps with fungal infections faster?

The speed of action of drugs may depend on the type of infection and the individual patient. In some cases, nystatin may be more effective and faster acting, in other cases, clotrimazole may show better results. It is better to consult a doctor to choose the most suitable drug.

What is the best drug to use to treat fungal infections in men?

For the treatment of fungal infections in men, the use of clotrimazole is generally recommended. This drug is effective in treating fungal balanitis (inflammation of the glans penis) and other fungal infections on the skin of the genitals.

Which drug is better to choose for the treatment of fungal infections in children?

Nystatin is generally recommended for the treatment of fungal infections in children. This drug is considered safe and effective for treating candidiasis in children, including fungal infections in the navel, mouth, and groin.

What is the best drug for the treatment of fungal infections of the vagina?

Clotrimazole is generally recommended for the treatment of fungal infections of the vagina. This drug is available as a cream or suppository and is indicated for the treatment of vaginal candidiasis (thrush) in women.

What is the best drug for the treatment of fungal infections of the nails?

Clotrimazole is generally recommended for the treatment of fungal nail infections. This medication is available as a cream or nail polish and can help clear up a fungal nail infection. In some cases, a systemic antifungal drug may be required.

Physicians’ advice on choosing a drug

When choosing between nystatin and clotrimazole for the treatment of fungal infections of the skin and mucous membranes, physicians recommend proceeding from the specific situation and characteristics of the patient.

Clotrimazole is a more commonly used drug that is effective against a wide range of fungal infections. It can be used to treat candidiasis of the skin, vagina, oral cavity, as well as to prevent relapses. Clotrimazole is available in various forms, including creams, ointments, solutions and suppositories, which allows you to choose the most convenient form of application for the patient.

Nystatin, on the other hand, is a narrow-spectrum drug that is only effective against Candida albicans. It has a high degree of safety and can be used even in pregnant and lactating women. Nystatin is available as a cream, ointment, and suspension.

When choosing a drug, doctors also take into account the individual preferences of the patient, his age, the presence of allergic reactions and other diseases. It is important to remember that self-treatment of fungal infections can lead to worsening of symptoms and complications. Therefore, before starting treatment, it is necessary to consult a doctor and follow his recommendations.

Antifungal suppositories: types, how to choose, effectiveness

Where can I buy?

Encyclopedia

Fungus

In women, intravaginal antifungal suppositories are indicated for infections of the vaginal mucosa caused by Candida fungi.

The author of the article

Molchanov Oleg Leonidovich

Gynecologist, reproductive specialist, doctor of medical sciences.

What is vaginal candidiasis?

Vulvovaginal candidiasis (thrush) is an infectious disease accompanied by inflammation of the mucous membrane of the vagina and vulva (external genitalia) caused by fungi of the genus Candida ¹ . Vaginal candidiasis is one of the most common gynecological diseases ² .

The incidence of thrush

In recent years, the incidence of thrush has increased by 2 times. At present, the prevalence of this disease in the world is about 3 million cases per year ^2.3 .

Approximately 75% of women of childbearing age suffer one case of thrush, 40-45% have 2 or more episodes of the disease, and 10-20% of women have a chronic thrush with frequent exacerbations ² .

Causes of thrush

Under the influence of adverse factors (stress, decreased immunity, hormonal disorders, antibiotics), active growth and reproduction of yeast-like fungi of the genus Candida on the mucous membrane of the female genital organs is stimulated. In 76-89% of cases ³ thrush is caused by a certain type of fungus – Candida albicans. Less commonly, this disease can be caused by Candida glabrata, Candida krusei, and other species that belong to the Candida non-albicans group ³ . Determining the type of fungus is important for choosing a drug for the treatment of thrush.

Symptoms of thrush

Symptoms of thrush on the external genitalia:

Redness and swelling

Cutting, burning pain

Discomfort and itching in the perineum

Thick whitish discharge with a sour smell om

Treatment of thrush

The main goal of therapy is the destruction of pathogens, fungi of the genus Candida.

Modern antifungal (antimycotic) agents must meet the following requirements:

efficiency
minimal risk of side effects
good tolerance
affordable price

Mechanism of action of antifungal drugs – inhibition of reproduction processes, violation of the integrity of the fungal cell and its subsequent death ^{1-4. 5} .

Groups of drugs for the treatment of vaginal candidiasis (thrush)

There is a wide range of antifungal agents with different chemical structures that are used to treat thrush.

Polyene preparations

Nystatin, Natamycin

Imidazole preparations

Ketoconazole, Clotrimazole, Miconazole, Sertaconazole, Butoconazole

Triazole preparations

900 02 Fluconazole, Itraconazole

Other preparations

Griseofulvin, Flucytosine, Decamine, Nitrofugin, Potassium iodide

Features of topical remedies for the treatment of thrush

Topical antifungal agents are drugs that are applied / injected directly at the site of inflammation. Such funds are produced in the form of vaginal suppositories (suppositories), vaginal tablets, in the form of a cream or solutions for douching.

Types of antifungal suppositories

Sertaconazole

Features of action

Sertaconazole destroys the cell wall of the fungus, causes its death. Stops inflammation, relieves pain, swelling and redness.

Effective against Candida albicans and non-albicans.

How to treat thrush with antifungal suppositories, see a short video by Professor, Doctor of Medical Sciences, Shikh Evgenia Valerievna.

Zalain

^® suppositories based on sertaconazole. Dosage and administration regimen

The drug is prescribed for the treatment of vulvovaginal candidiasis (thrush). Suitable for the treatment of both an acute case of the disease and for the treatment of relapses of thrush.

Inserted into the vagina once for the entire course of treatment. If symptoms persist, it is recommended to repeat a single injection of one Zalain ^® suppository 7 days after the initial application. The use of 1 vaginal suppository is explained by the fact that sertaconazole has a high lipophilicity – it dissolves well in lipid (fat) cell structures. Due to this, the drug is stored in the vaginal mucosa for a long time (7 days) in a therapeutic concentration, having a triple mechanism of action on Candida fungi: it stops the growth and reproduction of fungi, contributes to their death and prevents the transition of fungi into a pathogenic form ¹⁴ .

How to choose antifungal suppositories?

Based on these criteria, preparations based on sertaconazole, a modern molecule that is the main active ingredient in Zalain ^® suppositories, meet modern consumer requirements in terms of ease of use and effect.

Antifungal suppositories Zalain ^®

Zalain ^® It is enough to use suppositories once, which is a course dose for the treatment of vulvovaginal candidiasis. In case of recurrent candidiasis, after 7 days, 1 suppository should be reintroduced into the vagina. An essential feature of Zalain ^® is that the treatment can be carried out on critical days ¹² .

In scientific studies, sertaconazole (the main active ingredient Zalain ^® ) has shown greater activity in the treatment of thrush than a number of other drugs ⁷ .

Treatment with sertaconazole was generally free of side effects ⁸ .

Given that Zalain ^® in the form of vaginal suppositories acts locally (on the vaginal mucosa) and is not absorbed into the general circulation, the use of this drug is possible for the treatment of thrush during pregnancy, as well as during lactation (breastfeeding a child), if the benefit to the mother is higher than the potential negative effects for the child ^9.10 . The criteria for cure are the disappearance of manifestations of the disease and negative tests for the presence of the pathogen in vaginal smears ¹¹ .

Only 1 suppository per course

Local effect of the drug

No absorption of sertaconazole into the bloodstream ¹³

Can be used during pregnancy and lactation*

*if the benefits outweigh the risks

Where to buy Antifungal suppositories Zalain ^®

Instruction

Prevention of vaginal candidiasis in women

Currently, there is an increase in the number of chronic forms of vulvovaginal candidiasis, so the prevention of its repeated episodes is given great attention by gynecologists ^3.6 . The prevention of primary episodes of thrush remains relevant. Vaginal candidiasis is often observed in conditions associated with the use of antibiotics. Fungi of the genus Candida actively multiply when the microflora in the vagina is disturbed and the rules of intimate hygiene are not observed.

Therefore, for the prevention of thrush, it is necessary to adhere to the following recommendations:

maintain immunity

treat chronic diseases

lead a healthy lifestyle, give up bad habits

properly and regularly exercise intimate hygiene (use special products for hygiene of delicate areas)

apply barrier methods of contraception (use condoms)

refuse to wear synthetic materials and panty liners

For intimate care, including in cases of vaginal candidiasis and / or at risk of their occurrence, many gynecologists recommend the use of special products, for example, cosmetic product Zalagel ^® Intim with tea tree oil. This tool has in its composition unique components that have antibacterial, soothing and antiprotozoal (detrimental to protozoan organisms) action. Due to the special pH (8-9), the components of this gel create a destructive environment for fungi.

Frequently Asked Questions

Which is better, antifungal suppositories or vaginal tablets?

Answer: The base of suppositories is usually oily, which ensures ease of insertion and rapid dissolution under the influence of body temperature.

Vaginal tablets can be more difficult to insert into the vagina due to the “dry” texture, burning and discomfort may occur during insertion. This should be remembered especially if there is severe vaginal dryness or severe inflammation.

How to wash with thrush at home?

Answer: Proper cleansing of the genital organs is a very important measure along with treatment. It is possible to use running water to keep the intimate area clean. Regular soaps, non-intimate products, and frequent douching can disrupt the natural acidity (pH) of the vagina and lead to infection. It can also aggravate the condition with an already ongoing illness. It is important to choose the right product for the hygiene of the genital organs. For example, the cosmetic Zalagel ^® Intimacy with tea tree oil gently cleanses and moisturizes the intimate area.

What amount of Candida is considered normal in a vaginal swab?

Answer: fungi are normally present in the vagina in an amount not exceeding 10 ⁴ CFU/ml. With an increase in the number of fungi above this value, symptoms of the disease develop.

Resources

Guidelines for outpatient care in obstetrics and gynecology. Edited by V. N. Serov, G. T. Sukhikh, V. N. Prilepskaya, V. E. Radzinsky. 3rd edition, revised and enlarged; publishing house // GEOTAR-Media
Prilepskaya V. N., Kira E. F., Apolikhina I. A. et al. ROAG. Clinical Guidelines for the diagnosis and treatment of diseases accompanied by pathological discharge from the female genital tract; 2019.
Ogneshchenko N. A. Vulvovaginal candidiasis: what’s new? Published online 2012:70-72.
A. L. Popova, S. A. Dvoryansky. Modern aspects of treatment and prevention of vulvovaginal candidiasis (literature review).
Abdellatif M. M, Khalil I. A, Elakkad Y. E, Eliwa H. A, Samir T. M, Al-Mokaddem A. K. Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis. Int J Nanomedicine. 2020. doi:10.2147/IJN.S250960
Torres J., Márquez M., Camps F. Sertaconazole i. n the treatment of mycoses: from dermatology to gynecology // Int J Gynaecol Obstet. 2000 Dec;71 Suppl 1:S3-20
Pfaller M. A., Sutton D. A. // Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections // Diagn Microbiol Infect Dis. 2006 Oct;56(2):147-52 // doi: 10.1016/j.diagmicrobio.2006.04.006.
Carrillo-Muñoz A. J, Giusiano G., Ezkurra P. A, Quindós G. Sertaconazole: updated review of a topical antifungal agent. Expert Rev Anti Infect Ther. 2005 PMID: 15954850.
Prilepskaya VN, Bayramova GR Efficacy and acceptability of combination therapy for chronic recurrent vulvovaginal candidiasis. Venerologist 2006; 4: 55–57
Savicheva A. M., Kisina V. I., Sokolovsky E. V. et al. Vulvovaginal candidiasis. Methodical recommendations for doctors. St. Petersburg: Publishing House N. L. // 2009
According to the information leaflet Zalagel Intim®
According to the official instructions for use of the drug Zalain (State Register of Medicines https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=3bd5386b-0075-43 4d-a6ef-74ab056650ae)
Rogovskaya S.I., Bebneva T.N., Tkachenko L.V. Possibilities of local forms of antifungal agents in the treatment of genital candidiasis. Obstetrics and gynecology. 2015; 11: 121-125
Carrillo-Muñoz AJ, Tur-Tur C, Giusiano G, Marcos-Arias C, Eraso E, Jauregizar N, Quindós G. Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis.