Ondansetron dissolve: Ondansetron (Oral Route, Oromucosal Route) Proper Use
Ondansetron oral dissolving tablet
Brand Name: Zofran ODT
What is this medicine?
ONDANSETRON (on DAN se tron) is used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery.
How should I use this medicine?
These tablets are made to dissolve in the mouth. Do not try to push the tablet through the foil backing. With dry hands, peel away the foil backing and gently remove the tablet. Place the tablet in the mouth and allow it to dissolve, then swallow. While you may take these tablets with water, it is not necessary to do so.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- confusion
- dizziness
- fast or irregular heartbeat
- feeling faint or lightheaded, falls
- fever and chills
- loss of balance or coordination
- seizures
- sweating
- swelling of the hands and feet
- tightness in the chest
- tremors
- unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- constipation or diarrhea
- headache
What may interact with this medicine?
Do not take this medicine with any of the following medications:
- apomorphine
- certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
- cisapride
- dofetilide
- dronedarone
- pimozide
- thioridazine
- ziprasidone
This medicine may also interact with the following medications:
- carbamazepine
- certain medicines for depression, anxiety, or psychotic disturbances
- fentanyl
- linezolid
- MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
- methylene blue (injected into a vein)
- other medicines that prolong the QT interval (cause an abnormal heart rhythm)
- phenytoin
- rifampicin
- tramadol
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 2 and 30 degrees C (36 and 86 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- heart disease
- history of irregular heartbeat
- liver disease
- low levels of magnesium or potassium in the blood
- an unusual or allergic reaction to ondansetron, granisetron, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
- breast-feeding
What should I watch for while using this medicine?
Check with your doctor or health care professional as soon as you can if you have any sign of an allergic reaction.
NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier
Ondansetron (Zofran)
How does this medicine work?
Ondansetron (on-dan-se-tron) is a medicine used to treat and prevent nausea and vomiting.
How should I give it?
Ondansetron may be given by mouth as a liquid, pill, or tablet; or in a vein (IV). It may be given in one of these ways:
- as needed
- at regular times
- continuously through an IV
Your child should be awake and alert when taking any medicine by mouth. Follow the checked instructions below:
___ If using the liquid form, draw up the correct amount in the medicine dropper or oral syringe. Give a small squirt of the medicine inside the cheek. To avoid choking, let your child swallow each squirt before giving more.
___ For babies, you may want to mix the medicine with a small amount of formula or breast milk and give it with a bottle nipple before feeding. Do not add the medicine to a whole bottle because if your baby does not finish it, you will not know how much of the medicine was taken.
___ For older children who cannot swallow pills, a special tablet called Zofran ODT (oral disintegrating tablet) is available. Place it under the tongue and it will dissolve.
Other instructions:
Are there any precautions about food or other medicines?
This medicine may be given with or without food.
Check with the doctor, nurse practitioner, or pharmacist before giving any other prescription or non-prescription medicines, herbs, or vitamins.
What should I do if a dose is missed?
If a dose is missed, give it as soon as you remember. Never give a double dose.
If your child vomits a regular dose (not of the ODT type) within 30 minutes after receiving it, give it again. If your child vomits the second dose, do not repeat it again. If your child vomits an ODT dose, do not repeat it. Ondansetron ODT is absorbed into the body right away.
If your child misses or vomits two doses in a row, please call the clinic.
What are the side effects?
Common
- headache
- constipation
Occasional
- fatigue
- change in liver tests (with long-term use)
- diarrhea
- feeling dizzy
When should I call the clinic?
- continued vomiting after 2 doses
- signs of allergic reaction:
- fever or chills
- rash or hives
- wheezing
- trouble breathing – call 911
What else do I need to know?
You and your child should know the names and doses of all medicines he or she is taking. Share this information with anyone involved in your child’s care. Please remember to bring the medicine container when your child comes to the clinic or emergency department.
Always make sure you have enough medicine on hand. Each time you refill the prescription, check to see how many refills are left. If no refills are left, the pharmacy will need 2 or 3 days to contact the clinic to renew the prescription.
Check the label and the expiration date before giving each dose. Ask your pharmacist what to do with outdated or unused medications. Empty them into the trash if there is no “take-back” program.
Store all medicines in their original containers and away from direct sunlight or heat. Do not store in humid places such as the bathroom. Keep them out of children’s reach; lock up if possible.
If too much or the wrong kind of medicine is taken, call the Poison Control Center toll-free at 1-800-222-1222. If your child is unconscious or has a seizure, call 911.
Questions?
This sheet is not specific to your child but provides general information. If you have any questions, please call the clinic or pharmacy.
Children’s Hospitals and Clinics of Minnesota
Patient/Family Education
2525 Chicago Avenue South
Minneapolis, MN 55404
Last reviewed 8/2015 ©Copyright
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Ondansetron, solution | Borimed
Prevention and treatment of nausea and vomiting caused by cytostatic chemo or radio therapy
Adult patients
The selection of dosing regime is determined by the severity of the emetogenic effect of antitumor therapy, depends on the dose and combination of the drugs used. The route of administration and daily dose of ondansetron may vary within the dose range of 8 mg to 32 mg.
Emethogenic chemotherapy and radiotherapy
Ondansetron may be administered rectally, orally (tablets or syrup), intravenously or intramuscularly.
For most patients receiving emetogenic chemotherapy or radiation therapy, ondansetron 8 mg should be given as a slow intravenous injection (over at least 30 seconds) or intramuscular injection immediately prior to chemotherapy or radiation therapy, followed by 8 mg orally every 12 hours
Ondansetron (oral or rectal) is recommended for the prevention of delayed or prolonged emesis during the first 24 hours after chemotherapy or radiotherapy, and should be continued for a further 5 days.
Highly emetogenic chemotherapy
For patients receiving highly emetogenic chemotherapy, such as high doses of cisplatin, ondansetron can be given rectally, orally (tablets or syrup), intravenously, or intramuscularly. Ondansetron is prescribed according to the following (equally effective) dosing regimens during the first 24 hours of chemotherapy:
– a single dose of 8 mg intravenously slowly (at least 30 seconds) or intramuscularly immediately before chemotherapy;
A single dose of 8 mg intravenously slowly (over at least 30 seconds) or intramuscularly immediately before chemotherapy, followed by two additional intravenous (at least 30 seconds) or intramuscular injections of 8 mg every 4 hours or continuous infusion at a rate of 1 mg/h for 24 hours;
– a single maximum initial dose of 16 mg, intravenously, diluted in 50-100 ml of isotonic sodium chloride solution or other compatible infusion fluid for at least 15 minutes immediately before chemotherapy. The initial dose of ondansetron may be followed by two additional (at a dose of 8 mg) intravenous (slow, over 30 seconds) or intramuscular injections every 4 hours. Ondansetron should not be given in a single dose exceeding 16 mg, due to the risk of increasing the length of the interval Qt.
The choice of dosing regimen is determined by the severity of emetogenic therapy. The effectiveness of ondansetron in highly emetogenic chemotherapy can be enhanced by a single intravenous administration of dexamethasone sodium at a dose of 20 mg before chemotherapy.
To prevent delayed or prolonged emesis, ondansetron (oral or rectal) is recommended for the first 24 hours after chemotherapy or radiotherapy and continued for a further 5 days.
Children
Prevention and treatment of nausea and vomiting induced by cytostatic chemotherapy in children ≥ 6 months of age
For children, the dose of ondansetron may be calculated based on surface area or body weight (see below). Ondansetron is administered intravenously, by infusion, in 25-50 ml of saline or other compatible infusion fluid over at least 15 minutes. There are no data from controlled clinical trials on the use of ondansetron for the prevention of delayed or prolonged nausea and vomiting during emetogenic chemotherapy in children.
There are no data from controlled clinical trials on the use of ondansetron for the treatment of nausea and vomiting during radiotherapy in children.
Dose calculation based on body surface area
Ondansetron should be administered immediately prior to chemotherapy as a single intravenous injection at a dose of 5 mg/m 2 . A single intravenously administered dose should not exceed 8 mg.
Oral administration may begin after 12 hours and continue for up to 5 days.
The total dose over 24 hours (as divided doses) should not exceed 32 mg.
Dose calculation chart based on body surface area in children 6 months of age and older and adolescents for the prevention and treatment of nausea and vomiting associated with chemotherapy.
Body surface area | Day 1 (1, 2) | Day 2-6 (2) |
> 0.6 m 2 | 5 mg/m 2 IV + 2 mg syrup PO 12 hours later | 2 mg syrup orally 12 hours later |
≥ 0.6 m 2 and ≤ 1.2 m 2 | 5 mg/m 2 IV + 4 mg syrup PO q 12 h | 4 mg syrup or tablet by mouth every 12 hours |
> 1.2 m 2 | 5 mg/m 2 or 8 mg IV + 8 mg syrup orally every 12 hours | 8 mg syrup or tablet every 12 hours |
Notes:
- intravenous dose should not exceed 8 mg.
- the total daily dose (administered intravenously and orally) should not exceed 32 mg.
Doses of ondansetron for children may be calculated based on body weight. In this case, the total daily dose calculated on the basis of body weight is greater than the total daily dose calculated on the basis of body surface area.
Ondansetron should be administered intravenously immediately prior to chemotherapy as a single dose of 0.15 mg/kg. A single intravenous dose should not exceed 8 mg. Two more intravenous injections at a dose of 0.15 mg / kg can be administered with an interval of 4 hours. Oral administration of the drug can be started 12 hours after the end of chemotherapy and continued for up to 5 days.
Weight-Based Dose Chart in Children 6 Months of Age and Adolescents for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting.
Weight | Day 1 (1, 2) | Day 2-6 (2) |
≤ 10 kg | Up to three doses of 0.15 mg/kg IV every 4 hours | 2 mg syrup every 12 hours |
>10 kg | Up to three doses of 0.15 mg/kg IV every 4 hours | 4 mg syrup or tablets every 12 hours |
Notes:
- intravenous dose should not exceed 8 mg.
- the total daily dose (administered intravenously and orally) should not exceed 32 mg.
Prevention of postoperative nausea and vomiting
Adult patients.
For the prevention of postoperative nausea and vomiting, ondansetron can be used in oral form or by intravenous or intramuscular injection. Ondansetron can be administered intramuscularly in a single dose of 4 mg or by slow intravenous injection at the induction of anesthesia.
For the treatment of postoperative nausea and vomiting, a single intramuscular or slow intravenous dose of 4 mg is used.
Children
Prevention of postoperative nausea and vomiting in children ≥ 1 month of age and adolescents.
For the prevention and treatment of postoperative nausea and vomiting, a single dose of ondansetron is used as a slow intravenous injection at a dose of 0.1 mg/kg (maximum 4 mg) before, during, or after anesthesia.
There are no data on the use of ondansetron for the treatment of postoperative nausea and vomiting in children under 2 years of age.
Use in special patient groups.
Elderly patients.
For patients aged 65 to 74 years, dose adjustment is not required. There is limited experience with the drug in patients over 65 years of age for the prevention of postoperative nausea and vomiting, however, it is known that elderly patients well tolerate Ondansetron, prescribed for the prevention and treatment of nausea and vomiting caused by chemotherapy.
For patients aged 75 years and older, the initial intravenous dose of ondansetron should not exceed 8 mg. All doses for intravenous infusion should be diluted in 50-100 ml of isotonic sodium chloride solution or other compatible infusion fluid and administered over 15 minutes. The initial dose of 8 mg may be followed by two additional intravenous doses of 8 mg given over 15 minutes and at least 4 hours apart.
Patients with impaired renal function.
No dosage adjustment required.
Patients with impaired liver function.
In patients with moderate to severe hepatic impairment, the clearance of ondansetron is significantly reduced, the half-life is significantly increased. In such patients, the daily dose of ondansetron should not exceed 8 mg.
Patients with a slow metabolism of sparteine-debrizoquine.
In patients with a slow metabolism of spartein and debrisoquine, the half-life of ondansetron is not changed. Therefore, when the drug is re-administered to such patients, its plasma concentration will not differ from that in patients in the general population. Therefore, adjustment of the daily dose or dosing frequency of ondansetron is not required in this case.
Ondansetron Injection 2 mg/ml Ampoules 4 ml 5 pcs
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Product code:
36086
Manufacturer:
Sotex
Country of origin:
Russia
Release form:
Ampoules
Active ingredients:
Ondansetron
Dispensing order:
By prescription
There are contraindications, consult your doctor
Payment and methods of obtaining
Price:
281 ₽
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The price is valid only when ordering on the site
There are contraindications, consult a doctor
Manufacturer:
Sotex
Country of origin:
Russia
Release form:
Ampoules
Active ingredients:
Ondansetron
Dispensing order:
Prescription
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Features
Features
Tags | Antiemetics |
Registered as | Medicine |
Pack quantity | 5 pcs |
Information
Instructions for use
Active ingredients Ampoules
Composition
1 ml ondansetron (as hydrochloride dihydrate) 2 mg. Excipients: disodium edetate dihydrate – 1.5 mg, sodium hydroxide – 0.2-1 mg.
Pharmacological effect
Antiemetic. Effectively prevents and eliminates nausea and vomiting that occur against the background of antitumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block serotonin 5-HT3 receptors. It is believed that stimulation of the afferent fibers of the vagus nerve by serotonin released from the enterochromaffin cells of the gastrointestinal mucosa plays an important role in the occurrence of nausea and vomiting during antitumor therapy. By blocking 5-HT3 receptors, ondansetron prevents the occurrence of a gag reflex. In addition, ondansetron inhibits the central links of the gag reflex by blocking 5-HT3 receptors in the bottom of the IV ventricle (area postrema).
Indications
Prevention of nausea and vomiting during anticancer chemotherapy or radiotherapy. prevention and treatment of nausea and vomiting in the postoperative period.
Contraindications
I trimester of pregnancy, hypersensitivity to ondansetron.
Use during pregnancy and lactation
Ondansetron is contraindicated for use in the first trimester of pregnancy. If necessary, use during lactation should stop breastfeeding.
Method of administration and dosage
Individual, depending on indications and treatment regimen.
Side effects
From the side of the central nervous system: headaches. rarely – transient visual disturbances and dizziness (with rapid on / in the introduction), involuntary movements. From the side of the cardiovascular system: rarely – chest pain, arrhythmias, bradycardia, arterial hypotension. From the digestive system: constipation, diarrhea, abdominal pain, transient increase in the level of transaminases in the blood serum. Allergic reactions: rarely – bronchospasm, angioedema, urticaria. in some cases – anaphylactic reactions. Others: a feeling of warmth and a rush of blood to the head and epigastric region.
Special instructions
From the side of the central nervous system: headaches. rarely – transient visual disturbances and dizziness (with rapid on / in the introduction), involuntary movements. From the side of the cardiovascular system: rarely – chest pain, arrhythmias, bradycardia, arterial hypotension. From the digestive system: constipation, diarrhea, abdominal pain, transient increase in the level of transaminases in the blood serum. Allergic reactions: rarely – bronchospasm, angioedema, urticaria. in some cases – anaphylactic reactions. Others: a feeling of warmth and a rush of blood to the head and epigastric region.
Prescription
Yes
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