Explore the differences between Vagisil and Monistat. Discover which one is more effective, the coverage and cost comparison, and the potential side effects of each. Get a thorough understanding of the treatment options for yeast infections.

Understanding the Differences: Vagisil vs. Monistat

Vagisil and Monistat are two popular over-the-counter (OTC) medications commonly used for yeast infection treatment. While they are both used to address vaginal symptoms, such as itching and discomfort, they are quite different in terms of their ingredients and mechanisms of action.

Vagisil is an OTC local anesthetic cream that contains benzocaine and resorcinol, which work as external analgesics to relieve symptoms of burning and itching. Monistat, on the other hand, is an OTC antifungal cream that contains the active ingredient miconazole nitrate, which helps stop the growth of the fungus causing the yeast infection.

Conditions Treated by Vagisil vs. Monistat

Vagisil is intended to provide relief for external itching and irritation, but it does not actually treat the underlying yeast infection. Monistat, however, is specifically formulated to treat yeast infections by targeting the fungal infection internally.

So, while Vagisil may temporarily alleviate some of the symptoms, it will not cure the yeast infection. Monistat, on the other hand, is an effective antifungal that can help resolve the underlying issue causing the yeast infection.

Efficacy: Which One Works Better?

Comparing the efficacy of Vagisil and Monistat is challenging because they work in different ways. Vagisil can help with external itching, but it will not cure a yeast infection. Monistat, as an antifungal, has been shown to be effective in treating the root cause of the yeast infection.

If the itching is due to a yeast infection, Vagisil may provide temporary relief, but Monistat would be a more appropriate choice to address the underlying issue. Conversely, if the itching is not associated with a yeast infection, Vagisil may be helpful, while Monistat would not be an effective treatment.

Insurance Coverage and Cost Comparison

Since both Vagisil and Monistat are available OTC, they are typically not covered by insurance. Occasionally, an insurance plan may cover the generic form of Monistat. You can use a SingleCare card to save on either medication, but you’ll need a prescription in order to process the SingleCare savings, even though they are OTC products.

The prices for both Vagisil and Monistat can vary, so it’s important to compare prices and explore any available savings options to find the most cost-effective solution for your needs.

Potential Side Effects

The most common side effects of Vagisil include local skin irritation or inflammation and skin peeling. Other, less common side effects may include itching, redness, hives, stinging, and allergic reactions.

For Monistat, the most common side effects include headache, local burning sensation or irritation, and lower stomach cramping. Allergic reactions are very rare, but you should seek immediate medical attention if you experience symptoms such as swelling of the face, tongue, or throat, trouble breathing, dizziness, and/or rash.

Frequently Asked Questions

What is the difference between Vagisil and Monistat? Vagisil is a local anesthetic cream that provides relief for external itching and irritation, while Monistat is an antifungal cream that treats the underlying yeast infection.

Is Vagisil or Monistat more effective? Monistat is more effective in treating the root cause of a yeast infection, as it contains an antifungal agent. Vagisil may provide temporary relief for external symptoms, but it does not cure the yeast infection.

Are Vagisil and Monistat covered by insurance? Generally, no. Since they are both available OTC, they are typically not covered by insurance. Occasionally, the generic form of Monistat may be covered.

Prevention and Alternatives

To prevent yeast infections, it’s important to maintain good hygiene, wear breathable underwear, and avoid douching or using scented products. If over-the-counter treatments are not effective, it’s recommended to consult a healthcare provider for a proper diagnosis and treatment plan.

Other alternatives to Vagisil and Monistat may include prescription antifungal medications, as well as natural remedies such as boric acid suppositories or yogurt applications. It’s always best to discuss these options with your healthcare provider to determine the most appropriate course of action.

Differences, similarities, and which is better for you

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ | Prevention | Alternatives

If you’re suffering from a vaginal yeast infection, you’re not alone— about 75% of women will experience a yeast infection at least once. Yeast infections are most commonly caused by a fungus called Candida albicans and cause pesky symptoms such as itching, burning, and discharge. Vagisil and Monistat are two popular over-the-counter (OTC) medications commonly chosen by women for yeast infection treatment. 

Vagisil contains benzocaine and resorcinol, which work as external analgesics, relieving symptoms of burning and itching. Monistat contains miconazole, which is an antifungal that stops the growth of the fungus that is causing yeast infection. While both medications are used for vaginal symptoms, such as itching and discomfort, they are very different medications in terms of ingredients and how they work.  

What are the main differences between Vagisil and Monistat?

Vagisil is an OTC local anesthetic cream containing benzocaine 5% and resorcinol 2%. There is also a Vagisil maximum strength formulation which contains benzocaine 20% and resorcinol 3%, as well as a Vagisil sensitive anti-itch cream which contains hydrocortisone 1%, a steroid that helps with external itching. Although Vagisil is often thought of as a yeast infection treatment, it does not actually cure yeast infections.

Monistat is an OTC antifungal cream that contains the active ingredient miconazole nitrate. Monistat is available in a variety of formulations: a one-day (Monistat 1), three-day (Monistat 3), or seven-day (Monistat 7) treatment. You can buy Monistat as an internal vaginal cream or suppository. Some types of Monistat are available as a combination pack, with a tube of miconazole 2% cream that you can use externally to relieve symptoms. 

RELATED: Vagisil details | Monistat details | Miconazole details

Conditions treated by Vagisil vs.

Monistat

Vagisil contains benzocaine and resorcinol, which are local anesthetics used externally to relieve itching and irritation. Vagisil does not contain an antifungal, so while it may relieve symptoms externally, it will not treat the source of the yeast infection. 

Monistat contains the antifungal miconazole and is used vaginally, both internally and externally, to treat yeast infections. 

Is Vagisil or Monistat more effective?

It is difficult to compare the two drugs because they work differently. Vagisil can help with external itching, but will not cure a yeast infection. Therefore, if the itching is due to a yeast infection, Vagisil may help relieve symptoms temporarily, but will not cure the yeast infection that is causing the symptoms. If you are experiencing itching due to local irritation not associated with a yeast infection, Vagisil may be helpful, while Monistat would not be an effective treatment. 

Monistat has been shown to be effective as an antifungal and will help cure a yeast infection. Using the external cream in the combination pack (in addition to using the internal cream at bedtime) can help relieve symptoms while you wait for the infection to be cured.

You can always check with your doctor to see if Vagisil or Monistat is an appropriate choice for you because he or she should be familiar with your medical condition(s) and history.

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Coverage and cost comparison of Vagisil vs. Monistat

Because Vagisil and Monistat are available OTC, they are typically not covered by insurance. Occasionally, an insurance plan may cover the generic form of Monistat. You can use a SingleCare card to save on Vagisil or Monistat, but you’ll need your doctor to write a prescription in order to process the SingleCare savings. Even though the drugs are both OTC, the SingleCare card will only work with a prescription. 

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing.

Common side effects of Vagisil vs. Monistat

The most common side effects of Vagisil include local skin irritation or inflammation and skin peeling. Other, less common side effects that may occur include itching or redness, hives, stinging, and an allergic reaction. 

The most common side effects of Monistat include headache, local burning sensation or irritation, and lower stomach cramping. An allergic reaction is very rare, but you should seek immediate medical attention if symptoms occur. Symptoms can include swelling of the face, tongue, or throat, trouble breathing, dizziness, and/or rash.

Other side effects may occur. Consult your gynecologist for a full list of side effects. 

Drug interactions of Vagisil vs. Monistat

Both drugs have very few drug interactions since they are used topically. Vagisil should not be used with retinoids, such as adapalene or tretinoin, because the combination could be too irritating to the skin.  

Monistat should not be used in combination with Coumadin (warfarin), an anticoagulant that is also known as a blood thinner. The combination could lead to increased levels of warfarin in the body, which could lead to bleeding. 

Consult your healthcare provider for more information on drug interactions of Vagisil or Monistat. 

Warnings of Vagisil and Monistat

Vagisil warnings: 

• Vagisil is intended for external use only and applied to the affected area. Do not apply to large areas of the body.
• Avoid contact with the eyes.
• Keep out of reach of children.
• If symptoms do not improve within 7 days, consult your doctor. 

Monistat warnings:

• Consult a doctor if you have never been diagnosed with a yeast infection. Do not use Monistat unless you have previously been diagnosed with a vaginal yeast infection. A yeast infection can have similar symptoms to bacterial vaginosis, so if this is the first time you are experiencing symptoms, it is best to get evaluated by a doctor.  
• Check with your doctor before using Monistat if:
  • Your symptoms are accompanied by lower abdominal, back, or shoulder pain, fever, chills, nausea, vomiting, or foul-smelling vaginal discharge. These symptoms may indicate a more serious condition. 
  • You have vaginal yeast infections often.
  • You have been exposed to HIV.
• Ask your doctor before using Monistat if you take Coumadin (warfarin).
• While using Monistat:
  • Avoid tampons, douches, spermicides, and other vaginal products. Monistat may damage condoms or diaphragms, which could expose you to pregnancy or sexually transmitted disease (STDs). 
  • Do not have vaginal sexual intercourse.
  • You may experience local burning, itching, or irritation.
• Consult your healthcare professional if your symptoms do not improve.  
• Keep out of the reach of children.

If you are pregnant, consult your doctor about the appropriate treatment for a yeast infection and/or vaginal itching. 

Frequently asked questions about Vagisil vs. Monistat

What is Vagisil?

Vagisil is an OTC cream that contains local anesthetics called benzocaine and resorcinol. It can help relieve vaginal itching and irritation, but will not cure an underlying infection. 

What is Monistat?

Monistat contains miconazole, an antifungal used to treat vaginal yeast infections. It is available OTC in a variety of formulations as a one-day, three-day, or seven-day treatment. The internal cream comes with disposable applicators and is used at bedtime. Some formulations of Monistat also contain a tube of miconazole cream to be used externally. 

Does Monistat burn if you don’t have a yeast infection? 

Monistat may cause a mild increase of vaginal burning, itching, and irritation when used, even without a yeast infection. The vaginal area is sensitive in general and prone to these side effects when applying any type of medication there. However, burning may be worse if you already have a yeast infection present. This is because Monistat may worsen vaginal discomfort that is caused by a yeast infection. Additionally, the shorter the duration of treatment, the more potent the medication is. Therefore, if you are prone to vaginal irritation from vaginal products in general, it may be better to try the three-day or seven-day treatment instead of the one-day treatment. 

Can Monistat cause burning?: How to stop monistat burning

One way to reduce the risk of irritation with Monistat is to use the combination pack that comes with external itch relief cream. To reduce the chances of side effects, use the ovule insert as directed, apply the external cream to the outside of the vagina only, and dry the genital area thoroughly after a shower, bath, or swim. Another important thing to remember is to not scratch the area, no matter how tempting it may be. Scratching can break the skin, potentially worsening irritation and increasing the risk of infection. Overall, it is normal to feel a mild increase of burning when taking Monistat, but if it becomes worse or intolerable, it is important to stop taking it and seek medical help.  

Are Vagisil and Monistat the same?

No. Vagisil helps relieve itching but does not cure infections. Monistat contains an antifungal, so it can help cure a yeast infection. 

Which is the best vaginal itch cream?: Vagisil vs. Monistat

If you have local itching that is not associated with a yeast infection, Vagisil may be sufficient to relieve symptoms. However, if your symptoms are due to a yeast infection, you need treatment with an antifungal, such as Monistat, to cure the infection. 

Can I use Vagisil with Monistat? 

While Vagisil and Monistat do not interact, it may be best to not use them together. Monistat’s product insert says that it should not be used with any other vaginal products because they may interfere with its effectiveness. Another thing to note is that using Vagisil with Monistat may make it difficult to see if Monistat is working to treat a yeast infection. Vagisil could cover up yeast infection side effects. If Monistat is ineffective and it is hard to tell, it could delay seeking medical care. However, it is best to consult a healthcare provider to see if it is okay to use these two products together based on individual circumstances. 

Can I use Vagisil or Monistat while pregnant?

Yeast infections can be common in pregnancy. According to the American Pregnancy Association, treatment with a vaginal suppository or cream is recommended under the care of your doctor. Ask your OB/GYN if it is safe for you to use Monistat. The manufacturer of Vagisil states that you should contact your doctor before using Vagisil if you are pregnant.

Can I use Vagisil or Monistat with alcohol?

The manufacturers of Vagisil and Monistat do not list any contraindications with alcohol. However, alcohol can increase the risk of yeast infections, so if you are experiencing a yeast infection or are prone to recurrent yeast infections, you may want to skip the alcohol.

Does Vagisil work for yeast infections?

No. Vagisil will help relieve itching but does not contain an antifungal to help the source of the infection. There is a product called Vagistat, from the manufacturers of Vagisil, which contains miconazole in an internal and external cream, similar to Monistat 3. If you are looking to cure a yeast infection, you will want to choose a product that contains an antifungal agent (such as Vagistat or Monistat), but not Vagisil. 

Which Monistat is most effective?

All three formulations of Monistat are similarly effective in treating yeast infections in approximately the same amount of time. If you are not feeling better in three days, or you have symptoms for more than seven days, see your doctor. 

How long does it take for Monistat to work?

Regardless of which product you choose, it can take up to seven days until you are fully cured.

What cures a yeast infection fast?

Using an antifungal medication as directed can be very helpful for fast relief. Studies have shown that creams and oral pills work in more than 90% of cases. 

How do I treat recurring yeast infections? 

You should talk to your doctor if you get four or more yeast infections per year because you may need to take prescription antifungal medicine for a few weeks or longer. This occurs in less than 5% of women. However, being immunocompromised increases the risk of recurrent yeast infections. You should also see your doctor if you do not have improvement within three days or if you have symptoms for more than seven days after starting a treatment. If you experience serious side effects, such as developing a rash, hives, abdominal pain, fever, chills, nausea vomiting, foul smelling vaginal discharge, or severe vaginal burning, stop the treatment and seek medical help. 

Yeast infection Prevention

The following lifestyle tips promote vaginal health and may help to prevent yeast infections:

• Wear cotton clothing and underwear.
• Wash with an unscented hypoallergenic soap, and dry thoroughly.
• Wipe from front to back.
• Change out of your swimsuit or any damp clothing (such as workout clothing) as soon as possible.
• Avoid the use of douches (such as Summer’s Eve), feminine hygiene sprays, sanitary products that contain deodorant, scented soaps, bubble baths, and perfumed toilet paper. 
• Eat yogurt with live and active cultures and/or take probiotics, especially if you are taking antibiotics.
• Limit sugar in your diet.
• Drink more water and stay hydrated.

Yeast infection alternatives to Monistat and Vagisil

There are some alternatives to Monistat and Vagisil for treating and alleviating the symptoms of a yeast infection. They should never be used internally without consulting a doctor. These alternatives include:

• Apple cider vinegar: Drinking one spoonful mixed into a glass of water daily can inhibit the growth of Candida albicans.
• Cranberry juice or pills: These can help prevent the formation of Candida albicans in the urine. 
• Tea tree oil suppositories: Tea tree oil has antimicrobial and antifungal properties. It has been found to be effective against Candida albicans.
• Garlic: Garlic has antifungal properties and consuming it can help prevent or speed up treatment of yeast infections.
• Boric acid vaginal suppositories: These have been shown to treat recurrent or hard-to-treat yeast infections because of their potency. Milder treatments should be used first. Remember, if you are having difficulty treating a yeast infection, it is best to consult a doctor.
• Prescriptions: No matter what treatment you try, if there is no improvement within three days or if a yeast infection is still present after seven days, it may be time to get a prescription. You will most likely be prescribed an antifungal, such as fluconazole (oral tablets) or terconazole (vaginal cream).

Antifungal medicines: used to treat fungal infections

Antifungal medicines are used to treat fungal infections, which usually affect your skin, hair and nails.

You need a prescription for some antifungal medicines. But others are available over the counter from your pharmacy.

Talk to your GP or pharmacist if you think you have a fungal infection. They will tell you which antifungal medicine to take.

Antifungal medicines come as tablets, liquids, creams, gels, ointments, sprays, vaginal suppositories or injections.

Read the patient information leaflet that comes with your medicine for information specific to your type of antifungal medicine.

How to find your medicine’s patient information leaflet

Get emergency help

You may need emergency help if you have a serious allergic reaction or severe side effects to antifungal medicines.

Serious allergic reaction

Emergency action required: Call 999 or go to your nearest emergency department if:

you’ve taken antifungal medicines and you are:

• having difficulty breathing

Serious side effects

Urgent advice: Call your GP immediately if you’re taking antifungal medicine and:

• your face, neck or tongue swell – these are signs of an allergic reaction
• you have a severe skin reaction, such as peeling or blistering skin
• you experience loss of appetite, vomiting, nausea, jaundice, dark urine or pale faeces, tiredness or weakness

Stop using the medicine if you have these severe side effects.

Uses of antifungal medicines

Antifungals are used to treat common fungal infections such as:

• ringworm
• athlete’s foot
• fungal nail infection
• vaginal thrush
• some kinds of severe dandruff

They work by either:

• killing the fungal cells
• preventing the fungal cells growing and reproducing

Some fungal infections can grow inside the body and need to be treated in hospital.

You’re more at risk of getting a more serious fungal infection if you have a weakened immune system.

Types of antifungal medicines

Common names for antifungal medicines include:

• clotrimazole
• econazole
• miconazole
• terbinafine
• fluconazole
• ketoconazole
• amphotericin

Check if you can take antifungal drugs

Check with your GP or pharmacist if you:

• have an existing medical condition
• have any allergies
• are taking any other medication
• are trying to get pregnant, pregnant, or breastfeeding

Pregnant or breastfeeding

Many antifungal medicines are not safe to take during pregnancy or while breastfeeding. Check with your GP or pharmacist.

How and when to take antifungal medicine

Take your antifungal medicine as advised by your pharmacist or GP. The information leaflet with your medicine will also have advice on using your medicine.

Antifungal medicines for children

Children and babies can take some antifungal medicines. For example, miconazole oral gel can be used to treat oral thrush in babies.

But talk to a pharmacist or GP for more advice.

Different doses are usually needed for children of different ages.

If you take too much

Talk to your pharmacist or GP if you take too much of your antifungal medicine.

They may tell you to go to a hospital emergency department (ED).

If you go to the ED, take the medicine’s packaging with you. This is so the healthcare professionals who treat you know what you’ve taken.

Side effects of antifungal medicines

Antifungal medicines can cause side effects. These are usually mild and only last for a short time.

They can include:

• itching or burning
• redness
• feeling sick
• stomach (abdominal) pain
• diarrhoea
• a rash

See the patient information leaflet that comes with your medicine for a full list of side effects of your type of antifungal medicine.

You can report any suspected side effects to the Health Products Regulatory Authority (HPRA) – hpra.ie.

Finding your patient information leaflet online

Your patient information leaflet (PIL) is the leaflet that comes in the package of your medicine.  

Information:

To find your PIL online, visit Health Products Regulatory Authority (HPRA) – hpra.ie

1. In the ‘Find a medicine’ search box, enter the brand name of your medicine. A list of matching medicines appears.
2. To the right of your medicine, select ‘PIL’. A PDF of the PIL opens in a new window. 

You can also:

1. Select the brand name of your medicine.
2. Scroll down to the Documents section.
3. From the Package Leaflet line, select PDF version. A PDF of the PIL opens in a new window. 

If your PIL is not on the HPRA website, the European Medicines Agency (EMA) website opens in a new window when you select ‘PIL’.

You can find your PIL on the EMA website.

Finding your PIL on the EMA website

If your PIL is not on the HPRA website, you will be sent to European Medicines Agency (EMA) – ema.