About all

Pills for glaucoma. Comprehensive Guide to Glaucoma Medications: Types, Effects, and Treatment Options

What are the main types of glaucoma medications. How do different glaucoma eye drops work. What are the potential side effects of glaucoma treatments. How can patients ensure proper medication adherence for glaucoma management.

Содержание

Understanding Glaucoma and Its Treatment Approaches

Glaucoma is a complex eye condition that requires careful management to prevent vision loss. While there are various treatment options available, medications, particularly eye drops, play a crucial role in managing glaucoma symptoms and slowing disease progression. This comprehensive guide delves into the world of glaucoma medications, exploring their types, mechanisms of action, and considerations for effective treatment.

The Role of Eye Drops in Glaucoma Management

Eye drops are often the first line of defense in treating glaucoma. They work by either improving fluid drainage from the eye or reducing the production of intraocular fluid, both of which help lower eye pressure. For many patients, a combination of medications and laser treatment can effectively control eye pressure for years, preserving vision and quality of life.

How do glaucoma eye drops function?

Glaucoma eye drops primarily work through two mechanisms:

  1. Enhancing the drainage of fluid from the eye
  2. Decreasing the amount of fluid produced by the eye

These actions help reduce intraocular pressure, which is the primary goal of glaucoma treatment.

Major Classes of Glaucoma Medications

Glaucoma medications are classified based on their active ingredients. Each class has a unique mechanism of action and potential side effects. Understanding these differences can help patients and healthcare providers make informed decisions about treatment options.

Prostaglandin Analogs

Prostaglandin analogs are a popular class of glaucoma medications that work by increasing the outflow of fluid from the eye. Some common examples include:

  • Xalatan® (latanoprost)
  • Lumigan® (bimatoprost)
  • Travatan Z® (Travoprost)
  • Zioptan™ (tafluprost)
  • Vyzulta™ (latanoprostene bunod)

These medications are known for their effectiveness and relatively few systemic side effects. However, they may cause changes to the eye itself, such as alterations in iris color and eyelash growth. It’s worth noting that the efficacy and side effect profile can vary among individuals, so finding the right prostaglandin analog may require some trial and adjustment.

Beta Blockers

Beta blockers, with timolol being a prime example, are the second most commonly used class of glaucoma medications. They function by decreasing the production of intraocular fluid. Beta blockers are available in generic form, which can make them a more cost-effective option for some patients.

To minimize systemic side effects of beta blockers, patients can employ techniques such as closing their eyes after application or using punctal occlusion. This method prevents the drug from entering the tear drainage duct and systemic circulation, potentially reducing unwanted effects.

Alpha Agonists

Alpha agonists, such as Alphagan®P (brimonidine) and Iopidine®, have a dual action mechanism. They work to:

  1. Decrease the production of intraocular fluid
  2. Increase fluid drainage from the eye

Alphagan P features a unique purite preservative that breaks down into natural tear components, potentially making it more tolerable for patients who are sensitive to preservatives in other eye drops.

Carbonic Anhydrase Inhibitors (CAIs)

Carbonic anhydrase inhibitors reduce eye pressure by decreasing the production of intraocular fluid. These medications are available in both eye drop and pill form:

  • Eye drops: Trusopt® (dorzolamide), Azopt® (brinzolamide)
  • Pills: Diamox (acetazolamide), Neptazane® (methazolamide)

The availability of CAIs in different formulations provides flexibility in treatment options, allowing healthcare providers to tailor the approach to individual patient needs.

Rho Kinase Inhibitors

Rho kinase inhibitors, such as Rhopressa® (netarsudil), represent a newer class of glaucoma medications. These drugs increase the drainage of intraocular fluid through a unique mechanism. Introduced in April 2018, rho kinase inhibitors offer an additional tool in the glaucoma treatment arsenal, particularly for patients who may not respond adequately to other medication classes.

Combination Medications: Simplifying Glaucoma Treatment

For patients requiring multiple types of medication to manage their glaucoma, combination drugs can offer several advantages:

  • Convenience of using a single eyedrop bottle
  • Reduced exposure to preservatives
  • Potential cost savings, depending on insurance coverage

Some popular combination medications include:

  1. Cosopt®: Combines a beta blocker (timolol) and a carbonic anhydrase inhibitor (dorzolamide)
  2. Combigan®: Combines an alpha agonist (brimonidine) with a beta blocker (timolol)
  3. Simbrinza®: A beta blocker-free combination of brinzolamide and brimonidine

Addressing Treatment Challenges and Ensuring Medication Adherence

While glaucoma medications can be highly effective, their success largely depends on proper adherence to the prescribed regimen. Several factors can impact a patient’s ability to take their medications as directed:

How can patients improve their medication adherence?

To enhance medication adherence, patients can try the following strategies:

  • Link medication use to daily routines (e.g., taking drops while brushing teeth)
  • Set reminders using alarm clocks or smartphone apps
  • Use pill organizers or medication tracking tools
  • Communicate openly with healthcare providers about any challenges or concerns

Economic Considerations in Glaucoma Treatment

The cost of glaucoma medications can be a significant barrier to treatment adherence. Some ways to address this issue include:

  1. Discussing generic alternatives with your eye doctor
  2. Exploring patient assistance programs offered by pharmaceutical companies
  3. Checking with insurance providers about coverage options
  4. Considering combination medications that may offer cost savings

Managing Side Effects of Glaucoma Medications

Side effects can be a major concern for patients using glaucoma medications. These can range from mild irritation to more serious systemic effects. Understanding and addressing these side effects is crucial for maintaining treatment adherence and overall eye health.

What are common side effects of glaucoma eye drops?

Common side effects may include:

  • Ocular surface irritation (conjunctival and corneal)
  • Redness or itching of the eyes
  • Changes in iris color or eyelash growth (with prostaglandin analogs)
  • Systemic effects (e.g., respiratory issues with beta blockers)

For patients experiencing ocular surface irritation, preservative-free medications or those without the preservative BAK (benzalkonium chloride) may be beneficial. Examples include Zioptan, Cosopt PF, Timoptic in Ocudose, Travatan Z, and Alphagan P.

Advancing Glaucoma Treatment: New Developments and Future Directions

The field of glaucoma treatment is continuously evolving, with researchers and pharmaceutical companies working to develop new medications and delivery methods. Some promising areas of research include:

What innovative approaches are being explored for glaucoma treatment?

Emerging trends in glaucoma management include:

  1. Sustained-release drug delivery systems
  2. Gene therapy approaches
  3. Neuroprotective agents
  4. Combination therapies targeting multiple pathways
  5. Personalized medicine based on genetic profiles

These advancements aim to improve treatment efficacy, reduce side effects, and enhance patient compliance, ultimately leading to better outcomes for individuals living with glaucoma.

The Importance of Regular Monitoring and Follow-up Care

Effective glaucoma management extends beyond medication use. Regular monitoring and follow-up care are essential components of a comprehensive treatment plan. These visits allow healthcare providers to assess the effectiveness of current medications, make necessary adjustments, and detect any disease progression early.

How often should glaucoma patients have follow-up appointments?

The frequency of follow-up appointments can vary based on individual factors such as:

  • Severity of glaucoma
  • Stability of intraocular pressure
  • Presence of other eye conditions
  • Overall health status

Typically, patients may need to see their eye doctor every 3-6 months, but this can be more or less frequent depending on their specific situation.

During these appointments, healthcare providers may:

  1. Measure intraocular pressure
  2. Assess visual field and optic nerve health
  3. Review medication efficacy and side effects
  4. Discuss any concerns or questions the patient may have
  5. Adjust treatment plans as needed

Empowering Patients: Education and Self-Management in Glaucoma Care

Patient education plays a crucial role in successful glaucoma management. When patients understand their condition and treatment options, they are better equipped to actively participate in their care and make informed decisions.

How can patients become more involved in their glaucoma care?

Strategies for patient empowerment include:

  • Staying informed about glaucoma and its treatments
  • Keeping a record of symptoms, medication use, and side effects
  • Participating in support groups or educational programs
  • Communicating openly with healthcare providers
  • Adopting lifestyle changes that support eye health (e.g., regular exercise, healthy diet)

By taking an active role in their care, patients can work collaboratively with their healthcare team to achieve the best possible outcomes in managing their glaucoma.

Glaucoma Medications and their Side Effects

Currently, in the US, eye drops are often the first choice for treating patients. For many people a combination of medications and laser treatment can safely control eye pressure for years.

Eye drops used in managing glaucoma decrease eye pressure by helping the eye’s fluid to drain better and/or decreasing the amount of fluid made by the eye.

Drugs to treat glaucoma are classified by their active ingredient. These include: prostaglandin analogs, beta blockers, alpha agonists, carbonic anhydrase inhibitors, and rho kinase inhibitors. In addition, combination drugs are available for patients who require more than one type of medication. An older class of medications, the cholinergic agonists (such as pilocarpine) are not commonly used these days due to their side effects.

Types of Glaucoma Eye Drops

Prostaglandin analogs include Xalatan® (latanoprost), Lumigan® (bimatoprost), Travatan Z® (Travoprost), and Zioptan™ (tafluprost), and Vyzulta™ (latanoprostene bunod), and they work by increasing the outflow of fluid from the eye. They have few systemic side effects but are associated with changes to the eye itself, including change in iris color and growth of eyelashes. Depending on the individual, one of these preparations may be more effective and produce fewer side effects. Latanoprost and some formulations of bimatoprost are now available in generic form. Tafluprost is a preservative-free prostaglandin analog.

Beta blockers such as timolol are the second most often used class of medication and work by decreasing production of fluid. They are available in generic form and, therefore, may be less expensive. Timolol is also available in a preservative-free formulation. Systemic side effects of beta blockers can be minimized by closing the eyes following application or using a technique called punctal occlusion that prevents the drug from entering the tear drainage duct and systemic circulation.

Alpha agonists [Alphagan®P (brimonidine), Iopidine®] work to both decrease production of fluid and increase drainage. Alphagan P has a purite preservative that breaks down into natural tear components and may be better tolerated in people who have allergic reactions to preservatives in other eye drops. Alphagan is available in a generic form.

Carbonic anhydrase inhibitors (CAIs) reduce eye pressure by decreasing the production of intraocular fluid. These are available as eye drops [Trusopt® (dorzolamide), Azopt® (brinzolamide)] as well as pills [Diamox (acetazolamide) and Neptazane® (methazolamide)]. Except for brinzolamide, all CAIs are available in generic form.

Rho khinase inhibitors [Rhopressa® (netarsudil)] increase the drainage of intraocular fluid. This new class of glaucoma drug has been available since April 2018.

Combined medications can offer an alternative for patients who need more than one type of medication. In addition to the convenience of using one eyedrop bottle instead of two, there is decreased exposure to preservatives. There may also be a financial advantage, depending on your insurance plan. Cosopt® is a combination of a beta blocker (timolol) and a carbonic anhydrase inhibitor (dorzolamide) and is available in generic form and also as a preservative-free formulation (Cosopt® PF). Combigan® combines an alpha agonist (brimonidine) with a beta blocker (timolol). Simbrinza® is a beta blocker-free combination medication consisting of brinzolamide and brimonidine.

Treatment Concerns

Of course, no eye drop medication can be effective if it is not taken as prescribed. There are a number of reasons why people being treated for glaucoma may not take their medications.

One reason is that they simply forget! Remembering to take a daily medication is one of the challenges in the treatment of any chronic condition, and glaucoma is no exception. Some ways to help remember include tying a regular daily activity (such as brushing one’s teeth) to taking one’s medication, or setting timed reminders such as an alarm clock or cell phone.

A second factor in not taking medication as prescribed is economics. Glaucoma drugs can be expensive. Also, some medications may be covered by your insurance while others are not. Your eye doctor will work with you to recommend the best choice for you.

Another factor that influences the use of eyedrops is side effects. Besides adverse reactions specific to the active ingredient, ocular surface irritation (conjuctival and corneal) can occur with any type of eye drop. This irritation can be either new in a patient who never had symptoms before or can manifest as worsening of pre-existing ocular surface disease (such as dry eye, meibomitis, etc.). Preservative-free medications (Zioptan, Cosopt PF, Timoptic in Ocudose) or those without the preservative BAK (Travatan Z, Alphagan P) are often useful in this situation.

Laser Treatment

For patients who cannot tolerate medications or for whom medication alone has not been adequate, laser treatment continues to be an excellent alternative. It should be noted that laser may also be used as primary treatment. The advantage of this approach is that if adequate pressure lowering is achieved with laser treatment alone, the need for taking a daily medication may be delayed, along with the associated side effects.

The effect of laser treatment is typically not permanent, and many patients will eventually require medications. The most common laser treatments for glaucoma are selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT).

Side Effects of Glaucoma Medications

Following are some of the potential side effects of glaucoma medications.

  • Prostaglandin Analogs: eye color change, darkening of eyelid skin, eyelash growth, droopy eyelids, sunken eyes, stinging, eye redness, and itching
  • Beta Blockers: low blood pressure, reduced pulse rate, fatigue, shortness of breath; rarely: reduced libido, depression.
  • Alpha Agonists: burning or stinging, fatigue, headache, drowsiness, dry mouth and nose, relatively higher likelihood of allergic reaction.
  • Carbonic Anhydrase Inhibitors: in eye drop form: stinging, burning, eye discomfort; in pill form: tingling hands and feet, fatigue, stomach upset, memory problems, frequent urination.
  • Rho Kinase Inhibitors: eye redness, corneal deposits, stinging, and small bleeds on the white of the eye.

 

Side effects of combined medications may include any of the side effects of the drug types they contain.

For more information, please see our Glaucoma Medication Guide.

 

Article by Sunita Radhakrishnan, MD and Andrew G. Iwach, MD.
Posted on September 10, 2016.

Last reviewed on March 9, 2022.

Sunita Radhakrishnan, MD

Sunita Radhakrishnan, MD specializes in the medical and surgical treatment of glaucoma at the Glaucoma Center of San Francisco and is Research Director at the Glaucoma Research and Education Group in San Francisco.

Andrew G. Iwach, MD

Andrew G. Iwach, MD, is Associate Clinical Professor of Ophthalmology at the University of San Francisco, Executive Director of the Glaucoma Research and Education Group in San Francisco, and a faculty instructor at the California Pacific Medical Center Department of Ophthalmology.

Medication Guide | glaucoma.org

Medication Guide | glaucoma.org

Skip to content

Filter by Categories

Filter by Categories

A Guide to Glaucoma Medications

A number of medications are currently in use to treat glaucoma. Your doctor may prescribe a combination of medications or change your prescription over time to reduce side effects or provide a more effective treatment. Typically, medications are intended to reduce elevated intraocular pressure and prevent damage to the optic nerve.

>> en Español <<

Eye drops used in managing glaucoma decrease eye pressure by helping the eye’s fluid to drain better and/or decreasing the amount of fluid made by the eye. Drugs to treat glaucoma are classified by their active ingredient. These include: prostaglandin analogs, beta blockers, alpha agonists, carbonic anhydrase inhibitors, and rho kinase inhibitors. Combination drugs are available for patients who require more than one type of medication.

Alpha Agonist

Company

 Brand Name 

Generic Name

Allergan, Inc.

Alphagan®

Brimonidine tartrate 0.1%, 0.15%

Novartis

Iopidine®

Apraclonidine HCI 0. 5%, 1%

Alpha agonists work to both decrease production of fluid and increase drainage. Alphagan P has a Purite preservative that breaks down into natural tear components and may be more effective for people who have allergic reactions to preservatives in other eye drops. Brimonidine is available in a generic form.

Side Effects
Side effects can include burning or stinging upon instillation of the eye drop, fatigue, headache, drowsiness, dry mouth and dry nose.

Beta Blockers

Company

Brand Name 

Generic Name

Allergan, Inc. 

Betagan®

Levobunolol HCI 0.25%, 0.5%

Amring Pharmaceuticals Inc.

Timolol Maleate

Timolol Maleate 0. 5%

Bausch & Lomb, Inc. 

Istalol®

Timolol maleate ophthalmic solution 0.5%

OptiPranolol®

Metipranolol 0.3% 

Timoptic in Ocudose (PF)

Timolol Maleate Ophthalmic Solution 0.25%, 0.5% in Ocudose dispenser

Timoptic-XE® 

Timolol maleate ophthalmic gel forming solution 0.25%, 0.5%

Novartis

Betoptic® S

Betaxolol HCI 0.25%, 0.5%

Thea Pharma Inc.

Betimol® 

Timolol ophthalmic solution 0.25%, 0.5%

Beta blockers work by decreasing production of intraocular fluid. They are available in generic form and, therefore, are relatively inexpensive. Systemic side effects can be minimized by closing the eyes following application or using a technique called punctal occlusion that prevents the drug from entering the tear drainage duct and systemic circulation.

Side Effects
Side effects can include low blood pressure, reduced pulse rate, and fatigue. Beta blockers can also cause a shortness of breath in people who have a history of asthma or other respiratory disorders. Additionally, beta blockers can change cardiac activity by decreasing the amount of blood the heart pumps out, which may reduce the pulse rate and/or slow down the heart’s response rate during exercise. Rare side effects include reduced libido and depression.

Carbonic Anhydrase Inhibitors

Company

Brand Name 

Generic Name

Alembic Pharmaceuticals

Diamox

Acetazolamide

Fera Pharmaceuticals

Neptazane®

Methazolamide

Merck & Co. , Inc. 

Trusopt® 

Dorzolamide HCI 2%

Novartis

Azopt

Brinzolamide ophthalmic suspension 1%

Teva 

Diamox® Sequels® 

Acetazolamide

Carbonic anhydrase inhibitors (CAIs) reduce eye pressure by decreasing the production of intraocular fluid. These are available as eye drops and as pills. If you need to use more than one type of eyedrop, you may need to take each medicine in a certain order as prescribed by your doctor. If you are using more than one type of eyedrop, wait 5 minutes between eyedrop medicines. The pill form is an alternative for people whose glaucoma is not controlled by medication eye drops.

Side Effects
Side effects of the pill form of these medications can include tingling or loss of strength of the hands and feet, upset stomach, mental fuzziness, memory problems, depression, kidney stones, and frequent urination. Side effects of the eye drop include stinging, burning and other eye discomfort.

Cholinergic (Miotic)

Company

Brand Name 

Generic Name

Bausch & Lomb, Inc.

Pilocarpine HCI Ophthalmic Solution USP

Pilocarpine HCI 1%, 2%, 4%

Novartis 

Isopto® Carbachol

Carbachol 0.75%, 1.5%, 3%

Isopto® Carpine 

Pilocarpine HCI 1%, 2%, 4%

Pilopine HS® Gel 

Pilocarpine HCI gel 4%

These medications reduce eye pressure by increasing the drainage of intraocular fluid through the trabecular meshwork. Cholinergics can be used alone or combined with other glaucoma medications. A combination of medications can help control how much fluid is produced in the eye and increase the amount of fluid that drains out of the eye.

Side Effects
Many people who use these medications complain of dim vision, especially at night or in darkened areas such as movie theaters. This is due to constriction of the pupil. Miotics increase drainage of intraocular fluid by making the pupil size smaller, thereby increasing the flow of intraocular fluid from the eye.

 

Combined Medications

Company

Brand Name 

Generic Name

Alcon 

Rocklatan®

Netarsudil and Latanoprost ophthalmic solution 0.02%/0.005%

Simbrinza® 

Brinzolamide & Brimonidine tartrate 1%/0. 2%

Allergan, Inc.

Combigan®

Brimonidine tartrate & Timolol Maleate ophthalmic solution 0.2%/0.5%

Thea Pharma Inc. 

Cosopt®

Dorzolomide HCI & Timolol Maleate

Cosopt® PF 

Dorzolomide HCI & Timolol Maleate

Increases drainage of intraocular fluid.

Combined medications can offer an alternative for patients who need more than one type of medication. In addition to the convenience of using one eyedrop bottle instead of two, there may also be a financial advantage, depending on your insurance plan. Rocklatan is a combination of a rho kinase inhibitor and a prostaglandin analog. Combigan is a combination of beta blocker and alpha agonist. Cosopt is a combination of beta blocker and carbonic anhydrase inhibitor. Cosopt is available in generic form, and also as a presevative-free formulation (Cosopt PF). Simbrinza is a combination of Brinzolamide (a carbonic anhydrase inhibitor) and Brimonidine (an alpha agonist).

Side Effects
Side effects of Rocklatan include eye redness and stinging. Side effects of Combigan include the symptoms of beta blockers and alpha agonists. Side effects of Cosopt include burning and/or stinging of the eyes and changes in sense of taste. Side effects of Simbrinza Suspension include blurred vision, eye irritation, bad taste, dry mouth, and eye allergy.

Prostaglandin Analogs

Company

Brand Name 

Generic Name

Allergan, Inc. 

Durysta

Bimatoprost 10 mcg implant

Lumigan® 

Bimatoprost 0. 01%, 0.03%

Bausch & Lomb, Inc.  

Vyzulta

Latanoprostene bunod 0.024%

Novartis

Travatan® Z

Travoprost 0.004%

Pfizer 

Xalatan® 

Latanoprost 0.005%

Sun Ophthalmics

Xelpros

Latanoprost ophthalmic emulsion 0.005%

Thea Pharma Inc.

Zioptan

Tafluprost ophthalmic solution 0.0015% (PF)

Prostaglandin analogs work by increasing the outflow of intraocular fluid from the eye. They have few systemic side effects but are associated with changes to the eye itself, including change in iris color and growth of eyelashes. Depending on the individual, one brand of this type of medication may be more effective and produce fewer side effects. Prostaglandin analogs are taken as eye drops (except Durysta™ which is an implant). They are effective at reducing intraocular pressure in people who have open-angle glaucoma. Latanoprost and some formulations of bimatoprost and travoprost are available in generic form. Tafluprost is a preservative-free prostaglandin analog.

Side Effects
Side effects can include eye color change, darkening of eyelid skin, eyelash growth, droopy eyelids, sunken eyes, stinging, eye redness, and itching.

Rho Kinase Inhibitors

CompanyBrand NameGeneric Name
AlconRhopressa®Netarsudil 0.02%

Rho Kinase Inhibitors increase drainage of intraocular fluid by improving outflow of the trabecular meshwork.

Side Effects
Side effects can include eye redness, corneal deposits, stinging, and small bleeds on the white of the eye.


Last reviewed on March 17, 2023

Top of page

More About GRF

How can We Help?

Site Information

Stay in Touch