What is Piroxicam and how does it work. What are the common side effects of Piroxicam. How should Piroxicam be taken for optimal results. What are the potential drug interactions with Piroxicam. Who should avoid taking Piroxicam. What are the FDA warnings associated with Piroxicam. How does Piroxicam compare to other NSAIDs.

Understanding Piroxicam: An Overview of This Anti-Inflammatory Medication

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat symptoms of osteoarthritis and rheumatoid arthritis. Available as both a brand-name drug (Feldene) and in generic form, piroxicam comes as an oral capsule and requires a prescription. Its mechanism of action, while not fully understood, is believed to involve reducing levels of prostaglandin, a hormone-like substance that typically causes inflammation.

How Piroxicam Works in the Body

Piroxicam’s primary function is to alleviate pain, reduce inflammation, and lower fever. By targeting prostaglandin levels, it helps minimize swelling and discomfort associated with various forms of arthritis. This action makes piroxicam an effective choice for managing chronic pain conditions.

FDA Warnings and Precautions for Piroxicam Use

The Food and Drug Administration (FDA) has issued several black box warnings for piroxicam, which are the most serious warnings given to medications. These warnings highlight potential risks that both doctors and patients should be aware of before starting treatment.

• Heart disease risk: NSAIDs like piroxicam may increase the risk of serious heart-related problems, including heart attack and stroke.
• Ulcers and stomach bleeding: Piroxicam can cause ulcers and bleeding in the stomach and intestines, which can be fatal.
• Coronary artery bypass graft surgery: Piroxicam should not be used for pain relief after this type of surgery due to increased risk of heart attack or stroke.

Additional Warnings for Piroxicam

Beyond the black box warnings, there are several other precautions to consider when taking piroxicam:

• High blood pressure: Piroxicam can cause or worsen hypertension.
• Water retention: Patients with existing water retention or heart issues should monitor for symptoms of fluid retention.
• Asthma: Piroxicam may trigger asthma attacks in susceptible individuals.

Common Side Effects and How to Manage Them

While piroxicam is generally well-tolerated, it can cause various side effects. Understanding these potential reactions can help patients better manage their treatment.

Most Frequent Side Effects

The most common side effects associated with piroxicam include:

• Diarrhea
• Dizziness
• Headache
• Heartburn

These side effects are typically mild and may subside as the body adjusts to the medication. However, if they persist or worsen, it’s important to consult with a healthcare provider.

How can patients manage common side effects of piroxicam?

Patients can often manage common side effects by:
1. Taking the medication with food to reduce stomach upset
2. Staying hydrated to help alleviate dizziness
3. Using over-the-counter antacids for heartburn, if approved by their doctor
4. Resting and avoiding activities that require full alertness if experiencing dizziness

Serious Side Effects: When to Seek Immediate Medical Attention

While less common, piroxicam can cause serious side effects that require immediate medical attention. Recognizing these symptoms is crucial for patient safety.

Critical Side Effects to Watch For

• Allergic reactions (skin rash, itching, swelling of face or tongue)
• Signs of heart attack or stroke (chest pain, shortness of breath, weakness on one side, slurred speech)
• Kidney damage symptoms (decreased urination, swelling in extremities)
• Heart failure indicators (unusual weight gain, swelling)
• Stomach problems (severe pain, black stools, vomiting blood)
• Liver issues (yellowing of skin/eyes, flu-like symptoms, abdominal pain)
• Severe skin reactions (reddening, blistering, peeling)

What should patients do if they experience serious side effects from piroxicam?

If any serious side effects occur, patients should:
1. Stop taking piroxicam immediately
2. Contact their healthcare provider or seek emergency medical attention
3. Report the side effects to the FDA’s MedWatch program
4. Keep a detailed record of symptoms for discussion with their doctor

Dosage Guidelines and Administration Tips for Piroxicam

Proper dosage and administration of piroxicam are essential for maximizing its benefits while minimizing potential risks. The dosage may vary based on the condition being treated and individual patient factors.

Standard Dosage for Adults

• For osteoarthritis or rheumatoid arthritis: Typically 20 mg once daily
• Maximum daily dose: Should not exceed 20 mg

How should piroxicam be taken for optimal results?

To optimize piroxicam treatment:
1. Take the medication at the same time each day
2. Swallow the capsule whole with a full glass of water
3. Consider taking it with food to reduce stomach upset
4. Do not crush, chew, or open the capsule
5. Follow your doctor’s instructions precisely regarding dosage and duration of treatment

Drug Interactions: Medications to Avoid While Taking Piroxicam

Piroxicam can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbs you’re taking.

Common Drug Interactions

• Other NSAIDs (including aspirin)
• Blood thinners (e.g., warfarin)
• Certain antidepressants (SSRIs)
• ACE inhibitors and ARBs for blood pressure
• Diuretics
• Methotrexate
• Lithium

How can patients minimize the risk of drug interactions with piroxicam?

To reduce interaction risks:
1. Maintain an up-to-date list of all medications and supplements
2. Consult with a pharmacist or doctor before starting any new medication
3. Avoid over-the-counter NSAIDs unless approved by a healthcare provider
4. Consider alternative pain management strategies if multiple interactions are present

Special Populations: Who Should Exercise Caution with Piroxicam?

Certain groups of people may be at higher risk for complications when taking piroxicam. Understanding these risk factors is essential for safe and effective treatment.

High-Risk Groups

• Adults over 65 years old
• Patients with a history of stomach ulcers or bleeding
• Individuals with heart disease or risk factors for heart disease
• Those with kidney or liver problems
• Patients with asthma, especially if sensitive to aspirin
• Pregnant women, particularly in the third trimester
• Individuals with a history of allergic reactions to NSAIDs

What precautions should high-risk individuals take when prescribed piroxicam?

High-risk patients should:
1. Undergo regular monitoring by their healthcare provider
2. Start with the lowest effective dose
3. Use the medication for the shortest duration necessary
4. Be vigilant for signs of side effects or complications
5. Consider alternative treatments if risks outweigh benefits

Comparing Piroxicam to Other NSAIDs: Pros and Cons

While piroxicam shares many characteristics with other NSAIDs, it has unique properties that may make it more or less suitable for certain patients. Understanding these differences can help in making informed treatment decisions.

Advantages of Piroxicam

• Long half-life allowing for once-daily dosing
• Effective for both osteoarthritis and rheumatoid arthritis
• May have a lower risk of certain gastrointestinal side effects compared to some other NSAIDs

Disadvantages of Piroxicam

• Higher risk of serious cardiovascular events compared to some other NSAIDs
• Not suitable for acute pain relief due to slower onset of action
• May have more drug interactions than some newer NSAIDs

How does piroxicam compare to ibuprofen in terms of effectiveness and safety?

Comparing piroxicam to ibuprofen:
1. Piroxicam has a longer duration of action, allowing for once-daily dosing
2. Ibuprofen may have a faster onset of pain relief
3. Both carry risks of gastrointestinal and cardiovascular side effects
4. Piroxicam may be preferred for chronic conditions, while ibuprofen is often used for acute pain
5. Individual patient factors should guide the choice between these medications

In conclusion, piroxicam is a potent NSAID that offers effective relief for patients with osteoarthritis and rheumatoid arthritis. However, its use comes with significant warnings and potential side effects that require careful consideration. Patients should work closely with their healthcare providers to determine if piroxicam is the right choice for their specific situation, taking into account their medical history, other medications, and individual risk factors. Regular monitoring and open communication about any side effects or concerns are essential for safe and effective use of this medication. As with all NSAIDs, the goal is to achieve symptom relief while minimizing potential risks, making piroxicam a valuable but carefully managed option in the treatment of chronic inflammatory conditions.

Side Effects, Dosage, Uses, and More

Highlights for piroxicam

1. Piroxicam oral capsule is available as a brand-name drug and a generic drug. Brand name: Feldene.
2. Piroxicam comes only as a capsule you take by mouth.
3. Piroxicam oral capsule is used to treat rheumatoid arthritis and osteoarthritis.

FDA warning

• This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.
• Heart disease risk warning: Piroxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of serious heart-related problems, such as heart attack and stroke. Your risk may be higher if you’re taking this drug long term or at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
• Warning about ulcers and stomach bleeding that can result in death: Piroxicam can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. These conditions can be fatal. You’re at higher risk of these problems if you’re older than 65 years.
• Coronary artery bypass graft surgery warning: Don’t take piroxicam for pain after coronary artery bypass graft surgery. Doing so may increase your risk of a heart attack or stroke.

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Other warnings

• High blood pressure warning: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking this drug.
• Water retention and swelling warning: If you have water retention issues or heart problems, watch for symptoms of water retention when taking piroxicam.
• Asthma warning: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, don’t take piroxicam. It could also trigger an asthma attack.

Piroxicam is a prescription drug. It comes only as an oral capsule.

Piroxicam is available as the brand-name drug Feldene. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Why it’s used

Piroxicam is used to treat symptoms of osteoarthritis and rheumatoid arthritis.

How it works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Piroxicam oral capsule doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects that can occur with piroxicam include:

• diarrhea
• dizziness
• headache
• heartburn

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Allergic reaction. Symptoms can include:
• skin rash
• itching or hives
• swelling of your face, lips, or tongue
• Heart attack or stroke. Symptoms can include:
• chest pain
• shortness of breath
• weakness on one side of your body
• slurred speech
• Kidney damage. Symptoms can include:
• decreased urination
• swelling in your arms, legs, hands, or feet
• Heart failure. Symptoms can include:
• unusual weight gain
• swelling in your arms, legs, hands, or feet
• Stomach problems, such as ulcers and bleeding. Symptoms can include:
• stomach pain or upset stomach
• black, tarry stools
• vomiting blood
• Liver problems. Symptoms can include:
• yellowing of your skin or the whites of your eyes
• flu-like symptoms, such as body aches, fever, nausea, and vomiting
• tiredness
• pain in the upper part of your stomach
• itching
• Skin reactions. Symptoms can include:
• reddening, blistering, or peeling skin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Piroxicam oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with piroxicam are listed below.

Nonsteroidal anti-inflammatory drugs

Taking piroxicam with other NSAIDs may increase side effects, including stomach pain. Examples of other NSAIDs include:

• aspirin
• ibuprofen
• naproxen

Disease-modifying anti-inflammatory drug

Taking methotrexate with piroxicam can lead to dangerous levels of methotrexate in your body. This may cause side effects such as nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs

Taking certain blood pressure drugs with piroxicam might make those drugs not work as well. Examples of these drugs include:

• angiotensin-converting enzyme (ACE) inhibitors
• diuretics (water pills)

Anticoagulant/blood thinner

Taking warfarin with piroxicam increases your risk of stomach and intestinal bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Piroxicam can cause a severe allergic reaction. Symptoms may include:

• shortness of breath or trouble breathing
• chest pain
• weakness in one part or side of your body
• trouble speaking
• swelling of your face or throat

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interactions warning

Combining piroxicam and alcohol increases your risk of ulcer or stomach bleeding.

Warnings for people with certain health conditions

For people with asthma: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use piroxicam. It may have the same effect as aspirin.

For people with stomach ulcers or bleeding: This medication increases your risk of bleeding, ulcers, and tears (perforation) in the esophagus, stomach, and intestines. If you have a history of ulcers or stomach or intestinal bleeding and take piroxicam, watch for symptoms of these conditions. Symptoms include stomach pain, black, tarry stools, and vomiting blood. You’re at higher risk if you smoke, use alcohol, or are older than 65 years. Other factors that can increase your risk of bleeding include smoking and taking piroxicam with certain other medications, including antiplatelet drugs (such as aspirin), corticosteroids, selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors.

For people with kidney disease: Piroxicam can cause kidney damage if you use it for a long time. If you have serious kidney disease, you shouldn’t use this drug.

For people with high blood pressure: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

Warnings for other groups

For pregnant women: Piroxicam is a category C pregnancy drug. That means two things:

1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking piroxicam during your third trimester of pregnancy. It may harm your pregnancy.

Talk to your doctor if you’re pregnant or planning to become pregnant.

For women who are breastfeeding: Piroxicam passes through breast milk and may cause side effects in a child who is breastfed. It’s not recommended to breastfeed while taking this medication.

For seniors: If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of the drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

For children: The safety and effectiveness of piroxicam haven’t been established in children younger than 18 years.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Piroxicam

• Form: oral capsule
• Strengths: 10 mg and 20 mg

Brand: Feldene

• Form: oral capsule
• Strengths: 10 mg and 20 mg

Dosage for osteoarthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children than 18 years hasn’t been established.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Piroxicam oral capsule is used for short-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop or miss doses: If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If you take too much: If you take too much piroxicam, you may experience:

• fatigue
• drowsiness
• nausea
• vomiting
• stomach pain
• stomach bleeding

In rare cases, taking too much can cause dangerous allergic reactions, high blood pressure, kidney failure, trouble breathing, or coma.

If you think you’ve taken too much of this drug, call your doctor or local poison control center.

If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until your next dose, wait and take a single dose at the usual time. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have reduced arthritis pain.

Keep these considerations in mind if your doctor prescribes piroxicam for you.

General

• You can take piroxicam with food to reduce stomach irritation.
• This is an oral capsule, so it shouldn’t be cut or crushed.

Storage

• Store this drug at a temperature between 59°F and 86°F (15°C and 30°C).
• Keep the container tightly closed.
• Protect this medication from light.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do tests to check your health and make sure this drug is working for you. These tests include:

• blood test
• kidney function test
• liver function test

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Side Effects, Dosage, Uses, and More

Highlights for piroxicam

1. Piroxicam oral capsule is available as a brand-name drug and a generic drug. Brand name: Feldene.
2. Piroxicam comes only as a capsule you take by mouth.
3. Piroxicam oral capsule is used to treat rheumatoid arthritis and osteoarthritis.

FDA warning

• This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.
• Heart disease risk warning: Piroxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of serious heart-related problems, such as heart attack and stroke. Your risk may be higher if you’re taking this drug long term or at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
• Warning about ulcers and stomach bleeding that can result in death: Piroxicam can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. These conditions can be fatal. You’re at higher risk of these problems if you’re older than 65 years.
• Coronary artery bypass graft surgery warning: Don’t take piroxicam for pain after coronary artery bypass graft surgery. Doing so may increase your risk of a heart attack or stroke.

Was this helpful?

Other warnings

• High blood pressure warning: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking this drug.
• Water retention and swelling warning: If you have water retention issues or heart problems, watch for symptoms of water retention when taking piroxicam.
• Asthma warning: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, don’t take piroxicam. It could also trigger an asthma attack.

Piroxicam is a prescription drug. It comes only as an oral capsule.

Piroxicam is available as the brand-name drug Feldene. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Why it’s used

Piroxicam is used to treat symptoms of osteoarthritis and rheumatoid arthritis.

How it works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Piroxicam oral capsule doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects that can occur with piroxicam include:

• diarrhea
• dizziness
• headache
• heartburn

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Allergic reaction. Symptoms can include:
• skin rash
• itching or hives
• swelling of your face, lips, or tongue
• Heart attack or stroke. Symptoms can include:
• chest pain
• shortness of breath
• weakness on one side of your body
• slurred speech
• Kidney damage. Symptoms can include:
• decreased urination
• swelling in your arms, legs, hands, or feet
• Heart failure. Symptoms can include:
• unusual weight gain
• swelling in your arms, legs, hands, or feet
• Stomach problems, such as ulcers and bleeding. Symptoms can include:
• stomach pain or upset stomach
• black, tarry stools
• vomiting blood
• Liver problems. Symptoms can include:
• yellowing of your skin or the whites of your eyes
• flu-like symptoms, such as body aches, fever, nausea, and vomiting
• tiredness
• pain in the upper part of your stomach
• itching
• Skin reactions. Symptoms can include:
• reddening, blistering, or peeling skin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Piroxicam oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with piroxicam are listed below.

Nonsteroidal anti-inflammatory drugs

Taking piroxicam with other NSAIDs may increase side effects, including stomach pain. Examples of other NSAIDs include:

• aspirin
• ibuprofen
• naproxen

Disease-modifying anti-inflammatory drug

Taking methotrexate with piroxicam can lead to dangerous levels of methotrexate in your body. This may cause side effects such as nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs

Taking certain blood pressure drugs with piroxicam might make those drugs not work as well. Examples of these drugs include:

• angiotensin-converting enzyme (ACE) inhibitors
• diuretics (water pills)

Anticoagulant/blood thinner

Taking warfarin with piroxicam increases your risk of stomach and intestinal bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Piroxicam can cause a severe allergic reaction. Symptoms may include:

• shortness of breath or trouble breathing
• chest pain
• weakness in one part or side of your body
• trouble speaking
• swelling of your face or throat

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interactions warning

Combining piroxicam and alcohol increases your risk of ulcer or stomach bleeding.

Warnings for people with certain health conditions

For people with asthma: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use piroxicam. It may have the same effect as aspirin.

For people with stomach ulcers or bleeding: This medication increases your risk of bleeding, ulcers, and tears (perforation) in the esophagus, stomach, and intestines. If you have a history of ulcers or stomach or intestinal bleeding and take piroxicam, watch for symptoms of these conditions. Symptoms include stomach pain, black, tarry stools, and vomiting blood. You’re at higher risk if you smoke, use alcohol, or are older than 65 years. Other factors that can increase your risk of bleeding include smoking and taking piroxicam with certain other medications, including antiplatelet drugs (such as aspirin), corticosteroids, selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors.

For people with kidney disease: Piroxicam can cause kidney damage if you use it for a long time. If you have serious kidney disease, you shouldn’t use this drug.

For people with high blood pressure: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

Warnings for other groups

For pregnant women: Piroxicam is a category C pregnancy drug. That means two things:

1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking piroxicam during your third trimester of pregnancy. It may harm your pregnancy.

Talk to your doctor if you’re pregnant or planning to become pregnant.

For women who are breastfeeding: Piroxicam passes through breast milk and may cause side effects in a child who is breastfed. It’s not recommended to breastfeed while taking this medication.

For seniors: If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of the drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

For children: The safety and effectiveness of piroxicam haven’t been established in children younger than 18 years.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Piroxicam

• Form: oral capsule
• Strengths: 10 mg and 20 mg

Brand: Feldene

• Form: oral capsule
• Strengths: 10 mg and 20 mg

Dosage for osteoarthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children than 18 years hasn’t been established.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Piroxicam oral capsule is used for short-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop or miss doses: If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If you take too much: If you take too much piroxicam, you may experience:

• fatigue
• drowsiness
• nausea
• vomiting
• stomach pain
• stomach bleeding

In rare cases, taking too much can cause dangerous allergic reactions, high blood pressure, kidney failure, trouble breathing, or coma.

If you think you’ve taken too much of this drug, call your doctor or local poison control center.

If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until your next dose, wait and take a single dose at the usual time. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have reduced arthritis pain.

Keep these considerations in mind if your doctor prescribes piroxicam for you.

General

• You can take piroxicam with food to reduce stomach irritation.
• This is an oral capsule, so it shouldn’t be cut or crushed.

Storage

• Store this drug at a temperature between 59°F and 86°F (15°C and 30°C).
• Keep the container tightly closed.
• Protect this medication from light.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do tests to check your health and make sure this drug is working for you. These tests include:

• blood test
• kidney function test
• liver function test

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Interaction of Piroxicam-obl with other drugs

Learn about the interaction of Piroxicam-obl with other drugs, its side effects and rules of use. Piroxicam-obl is an effective anti-inflammatory drug that can be prescribed by a doctor for the treatment of various diseases. Before using the drug, it is necessary to familiarize yourself with information about its interaction with other drugs in order to avoid undesirable consequences and maximize the effectiveness of treatment.

Piroxicam is an effective anti-inflammatory drug that is often prescribed for the treatment of various diseases of the musculoskeletal system. However, before you start taking this drug, you must consider its interaction with other drugs.

It is important to remember that the simultaneous use of Piroxicam with other anti-inflammatory drugs may increase their action, which can lead to an increased risk of side effects.

In addition, while taking Piroxicam-reg with anticoagulants (drugs that reduce blood clotting), it is possible to increase their effect and increase the risk of bleeding.

It is important to note that with the simultaneous use of Piroxicam-reg with diuretics (drugs that increase the excretion of fluid from the body), water and electrolyte imbalance may occur.

Before you start taking Piroxicam-reg, you should consult with your doctor, who can assess the possible risks and side effects when taken with other drugs.

Drugs that affect the effectiveness of Piroxicam-reg

When Piroxicam-reg is used simultaneously with some other drugs, interactions may occur, as a result of which its effectiveness may change.

One of the drugs that affect the effectiveness of Piroxicam-reg is agents that have a negative effect on kidney function. Interaction with such drugs can lead to deterioration of kidney function and increased side effects of Piroxicam-reg.

The interaction of Piroxicam with anticoagulants (drugs that increase blood clotting) should also be taken into account, as this may lead to an increased risk of bleeding.

The simultaneous use of Piroxicam with other anti-inflammatory drugs is not recommended, as this may increase the risk of unwanted side effects and complications.

It is important to note that this information is not exhaustive, and before starting treatment with Piroxicam, you should consult your doctor and clarify possible interactions with other drugs.

Drugs that enhance the effect of Piroxicam-reg

Piroxicam-reg can be effectively enhanced when used simultaneously with other drugs. Some of them can increase the effectiveness and speed of action of Piroxicam-reg, which allows you to achieve faster pain relief and recovery of health.

One of the drugs that enhance the effect of Piroxicam-region is the analgesic Nimesulide. This drug has an analgesic and anti-inflammatory effect, which complements the action of Piroxicam-reg. Taking these medications in combination can greatly enhance pain relief and reduce inflammation.

Another drug that has shown good results in combination with Piroxicam is the glucocorticosteroid Prednisolone. This drug has a powerful anti-inflammatory effect and can enhance the effect of Piroxicam-reg, accelerating pain relief and recovery of health.

It is also worth noting the drug Meloxicam, which has a similar mechanism of action to Piroxicam-reg. Taking these drugs in combination can increase pain relief and reduce inflammation, allowing for faster recovery.

It is important to remember that before taking any medicines, including drugs that enhance the effect of Piroxicam-reg, you should consult your doctor and strictly follow the recommendations for dosage and regimen. Misuse of medications can lead to unwanted side effects and poor health.

Drugs that reduce the effectiveness Piroxicam-reg

Piroxicam-reg is an effective anti-inflammatory and analgesic drug that is widely used in medicine. However, there are some drugs that can reduce its effectiveness and reduce the desired therapeutic effect.

First of all, it is not recommended to combine Piroxicam-reg with other non-steroidal anti-inflammatory drugs such as Ibuprofen, Naproxen, Diclofenac, etc. This is due to the fact that all these drugs act on the same group of enzymes and can interact with each other, which will lead to a decrease in the effectiveness of Piroxicam-reg.

The concomitant use of Piroxicam with acetylsalicylic acid (aspirin) should also be avoided as this may increase the risk of side effects such as bleeding and stomach ulcers.

It is important to note that Piroxicam may increase the effects of anticoagulants (blood thinners), so you should be especially careful and consult your doctor if you are taking such medications.

In general, it is recommended that you consult your doctor or pharmacist before taking Piroxicam or any other medicines to avoid unwanted interactions and maximize the effectiveness of your treatment.

Drugs that interact with Piroxicam in the liver

Piroxicam is an anti-inflammatory and analgesic drug that is extensively metabolized in the liver. In this regard, there are a number of drugs that can affect its processing and effectiveness. The following is a list of drugs that interact with Piroxicam-reg in the liver:

• Acetylsalicylic acid: The use of Piroxicam-reg together with acetylsalicylic acid may increase the risk of bleeding and ulcerative lesions of the gastrointestinal tract.
• Methotrexate: Simultaneous use of Piroxicam-reg and methotrexate may increase the toxicity of the latter, especially to the liver.
• Lithium: Simultaneous use of Piroxicam-obl and lithium may cause an increase in the concentration of lithium in the blood, which can lead to toxic effects.
• Furosemide: Furosemide may reduce the effectiveness of Piroxicam-reg, because it reduces its plasma concentration.

It is important to remember that this is not a complete list of drugs that interact with Piroxicam in the liver. Before you start taking any medicines, including Piroxicam-reg, you should consult your doctor or pharmacist to avoid possible negative consequences.

Drugs that interact with Piroxicam-reg in the kidneys

Piroxicam-reg is a drug that is used to relieve pain and inflammation. However, when using it, it is necessary to take into account possible interactions with other drugs, especially with kidney damage.

Diuretics : Interactions with Piroxicam-reg can lead to a decrease in the effectiveness of diuretics, which can lead to fluid retention in the body and deterioration of kidney function. With the simultaneous use of these drugs, it is necessary to monitor the level of electrolytes in the blood and kidney function.

Anti-inflammatory and analgesic drugs : The combined use of Piroxicam-reg with other anti-inflammatory and analgesic drugs may increase the risk of side effects, especially on the kidneys. If you need a combined use, you should consult a doctor and monitor kidney function.

Antihypertensive drugs : Piroxicam may reduce the effectiveness of antihypertensive drugs, which can lead to an increase in blood pressure. With simultaneous use, it is necessary to regularly monitor blood pressure and, if necessary, adjust the dosage of antihypertensive drugs.

Anticoagulants : Piroxicam may increase the effect of anticoagulants, which may increase the risk of bleeding. With simultaneous use, it is necessary to control blood clotting and, if necessary, adjust the dosage of anticoagulants.

It is important to remember that this information is not exhaustive, and before starting the use of Piroxicam or combined treatment, you should consult your doctor and read the instructions for use.

Drugs that interact with Piroxicam-reg in the blood

When using the drug Piroxicam-reg, it is necessary to take into account its possible interaction with other drugs. Some drugs may affect the blood concentration of Piroxicam, which may cause unwanted effects or reduce its effectiveness.

Interactions of Piroxicam with acetylsalicylic acid (aspirin) may increase the risk of bleeding. Therefore, with the simultaneous use of these drugs, it is necessary to be especially careful and monitor the state of bleeding.

Some antiplatelet agents, such as cardioaspirin and clofibrate, may also increase the effect of Piroxicam and increase the risk of bleeding. When combining these drugs, it is necessary to carefully monitor the patient’s condition and, if necessary, adjust the dosage.

Preparations containing glucocorticosteroids (eg prednisolone) may also increase the effect of Piroxicam and increase the risk of erosive ulcerative lesions of the gastrointestinal tract. With the simultaneous use of these drugs, it is necessary to be especially careful and monitor the patient’s condition.

Interaction of Piroxicam with anticoagulants (eg warfarin) may increase their effect and increase the risk of bleeding. With the combination of these drugs, it is necessary to regularly monitor blood coagulability and, if necessary, adjust the dosage.

Some drugs, such as lithium and methotrexate, may increase the renal toxicity of Piroxicam. With the simultaneous use of these drugs, it is necessary to regularly monitor kidney function and, if necessary, adjust the dosage.

Piroxicam may decrease the effectiveness of diuretics such as furosemide. With the combination of these drugs, it is necessary to control diuresis and, if necessary, adjust the dosage of the diuretic.

Preparations containing magnesium, aluminum or calcium may reduce the absorption of Piroxicam and reduce its effectiveness. With the simultaneous use of these drugs, it is necessary to observe an interval of 2 hours between taking Piroxicam-reg and drugs containing these microelements.

Drugs that interact with Piroxicam-reg in the gastrointestinal tract

Piroxicam-reg is a drug that is widely used to treat various inflammatory diseases. However, when using it, it is necessary to take into account the possible interaction with other drugs, especially in the gastrointestinal tract.

Interaction of Piroxicam-reg with some drugs may lead to an increase or decrease in its effect. For example, concomitant use with anticoagulants (drugs that reduce blood clotting) may increase the risk of bleeding.

Caution should also be exercised when Piroxicam is used in combination with other anti-inflammatory drugs, as this may increase the risk of side effects, especially on the gastrointestinal tract.

It is important to remember that the interaction of Piroxicam with other drugs can be individual and depends on many factors, including dosage and duration of drug administration. Therefore, before starting treatment, it is necessary to consult a doctor and inform about all medications taken.

In general, when used correctly and following the doctor’s recommendations, Piroxicam is an effective drug for the treatment of inflammatory diseases. However, it is necessary to be careful and cautious when it is combined with other drugs, especially in the gastrointestinal tract.

Drugs that affect the pharmacokinetics Piroxicam-reg

Piroxicam-reg is an effective anti-inflammatory and analgesic drug, which is often used to treat various diseases of the musculoskeletal system. However, it is worth remembering that the interaction of Piroxicam with some other drugs can affect its pharmacokinetics.

One such drug is acetylsalicylic acid, which can enhance the effects of Piroxicam and increase the risk of side effects, especially on the digestive system. Therefore, with the simultaneous use of these drugs, it is necessary to be especially careful and consult a doctor.

Another drug that can affect the pharmacokinetics of Piroxicam is lithium salts. They can increase the toxic effect of Piroxicam-region on the kidneys, therefore, with the simultaneous use of these drugs, it is necessary to regularly monitor kidney function and monitor the level of lithium in the blood.

It should also be noted that the simultaneous use of Piroxicam-reg with diuretics can lead to an increase in their diuretic effect and an increased risk of kidney complications. Therefore, with the combined use of these drugs, it is necessary to regularly monitor kidney function and monitor the level of electrolytes in the blood.

It is important to remember that the interaction of Piroxicam with other drugs can be individual and depends on many factors, including dosage, duration of administration and the characteristics of the patient’s body. Therefore, before starting treatment with Piroxicam-Oblom, it is necessary to consult a doctor and inform about all medications taken.

Q&A:

Can Piroxicam-reg be taken with aspirin?

Yes, you can take Piroxicam with aspirin, but care must be taken as this may increase the risk of gastrointestinal side effects.

Can Piroxicam be taken with antibiotics?

Yes, you can usually take Piroxicam with antibiotics, but you should consult your doctor or pharmacist before starting the combination to avoid possible interactions and side effects.

Can Piroxicam-reg be taken with high blood pressure medicines?

No, it is not recommended to take Piroxicam with high blood pressure medications without first consulting a doctor, as this may increase the effect of high blood pressure medications and lead to serious side effects.

Can Piroxicam-reg be taken with diabetes medications?

Yes, in most cases you can take Piroxicam with your diabetes medications, but you should consult your doctor or pharmacist before starting the combination to avoid possible interactions and side effects.

Can I take Piroxicam with allergy medications?

Yes, you can usually take Piroxicam with allergy medications, but you should consult your doctor or pharmacist before taking it in combination to avoid possible interactions and side effects.

Can Piroxicam-reg be taken with gastritis drugs?

Yes, it is possible to take Piroxicam with gastritis medications, but care must be taken as this may increase the risk of gastrointestinal side effects.

Can Piroxicam obl be taken with headache medications?

Yes, Piroxicam-reg can be taken with anticoagulants, but this may increase the risk of bleeding. Therefore, it is necessary to consult a doctor before taking these drugs at the same time.

Can Piroxicam-reg be taken with aspirin?

Yes, Piroxicam can be taken with aspirin, but this may increase the risk of side effects such as bleeding or stomach ulcers. It is recommended that you consult your doctor before taking these drugs at the same time.

Can Piroxicam be taken with antibiotics?

Yes, Piroxicam-reg can be taken with antibiotics. However, some antibiotics may interact with Piroxicam and increase its side effects. Therefore, if you experience any side effects, you should consult your doctor.