Piroxicam anti inflammatory. Piroxicam: A Comprehensive Guide to Uses, Dosage, and Side Effects

13.02.202120.07.2023 by alexxlab

What are the uses of piroxicam. How does piroxicam work. What are the common side effects of piroxicam. What are the serious side effects to watch out for with piroxicam. How does piroxicam interact with other medications. What precautions should be taken when using piroxicam.

Содержание

Understanding Piroxicam: An Overview of the Anti-inflammatory Medication

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat symptoms of osteoarthritis and rheumatoid arthritis. Available as both a brand-name drug (Feldene) and in generic form, piroxicam comes as an oral capsule and requires a prescription. This medication works by reducing inflammation, pain, and fever, though its exact mechanism of action is not fully understood.

NSAIDs like piroxicam are believed to function by lowering levels of prostaglandin, a hormone-like substance that typically causes inflammation. By doing so, they help alleviate swelling and associated discomfort. While piroxicam can be an effective treatment option for many patients, it’s crucial to understand its potential side effects and interactions before use.

The Uses and Benefits of Piroxicam in Treating Arthritis

Piroxicam is primarily prescribed for two main conditions:

Osteoarthritis
Rheumatoid arthritis

For patients suffering from these forms of arthritis, piroxicam can provide significant relief from symptoms such as joint pain, stiffness, and inflammation. By reducing these symptoms, the medication can help improve mobility and quality of life for many individuals.

How effective is piroxicam in managing arthritis symptoms? Clinical studies have shown that piroxicam can be as effective as other NSAIDs in reducing pain and inflammation associated with both osteoarthritis and rheumatoid arthritis. However, individual responses may vary, and some patients may find greater relief with piroxicam compared to other NSAIDs, or vice versa.

Dosage and Administration: How to Take Piroxicam Safely

Piroxicam is available only as an oral capsule, typically taken once daily. The specific dosage will depend on various factors, including:

The condition being treated
The severity of symptoms
The patient’s age and overall health
Other medications being taken

It’s crucial to follow your healthcare provider’s instructions carefully when taking piroxicam. Taking more than the prescribed dose or using the medication for longer than recommended can increase the risk of side effects.

Can piroxicam be taken with or without food? Piroxicam can typically be taken with or without food. However, if you experience stomach upset when taking the medication, it may be helpful to take it with food or milk to reduce gastrointestinal discomfort.

Common Side Effects: What to Expect When Taking Piroxicam

Like all medications, piroxicam can cause side effects. While not everyone experiences these effects, it’s important to be aware of the possibilities. Common side effects of piroxicam include:

Diarrhea
Dizziness
Headache
Heartburn

These side effects are generally mild and may subside as your body adjusts to the medication. However, if these symptoms persist or worsen, it’s important to consult your healthcare provider.

How long do side effects typically last? The duration of side effects can vary from person to person. Some individuals may experience side effects only during the initial days or weeks of treatment, while others may have ongoing symptoms. If side effects are persistent or bothersome, your doctor may adjust your dosage or recommend alternative treatment options.

Serious Side Effects and Warnings: When to Seek Medical Attention

While less common, piroxicam can cause serious side effects that require immediate medical attention. These include:

Allergic reactions (skin rash, itching, swelling of face or tongue)
Heart attack or stroke symptoms
Kidney damage
Heart failure
Stomach problems, including ulcers and bleeding
Liver problems
Severe skin reactions

It’s crucial to be aware of the symptoms associated with these serious side effects and seek immediate medical care if they occur. Additionally, piroxicam carries several FDA black box warnings, which are the most serious warnings issued by the Food and Drug Administration.

FDA Black Box Warnings for Piroxicam

The FDA has issued the following black box warnings for piroxicam:

Increased risk of serious cardiovascular events, including heart attack and stroke
Risk of gastrointestinal ulcers, bleeding, and perforation, which can be fatal
Contraindication for use in treating pain following coronary artery bypass graft (CABG) surgery

These warnings highlight the importance of careful consideration and monitoring when using piroxicam, particularly in patients with existing cardiovascular risk factors or a history of gastrointestinal issues.

Drug Interactions: Understanding How Piroxicam Affects Other Medications

Piroxicam can interact with various other medications, potentially altering their effectiveness or increasing the risk of side effects. Some important drug interactions to be aware of include:

Other NSAIDs, including aspirin
Blood thinners (anticoagulants)
Certain antidepressants
Diuretics
ACE inhibitors and ARBs (used to treat high blood pressure)
Methotrexate (used to treat certain cancers and autoimmune conditions)

This list is not exhaustive, and it’s crucial to inform your healthcare provider about all medications, vitamins, and herbal supplements you’re taking before starting piroxicam.

Why is it important to avoid taking multiple NSAIDs together? Taking multiple NSAIDs simultaneously can significantly increase the risk of gastrointestinal side effects, including ulcers and bleeding. It can also heighten the risk of cardiovascular events. Always consult your healthcare provider before combining NSAIDs or adding a new medication to your regimen.

Special Precautions and Considerations for Piroxicam Use

Certain individuals may need to take special precautions when using piroxicam or may not be suitable candidates for this medication. These include:

Elderly patients (over 65 years old)
Individuals with a history of ulcers or gastrointestinal bleeding
Patients with cardiovascular disease or risk factors
Those with kidney or liver disease
Individuals with asthma, especially if sensitive to aspirin
Pregnant women, particularly in the third trimester
Breastfeeding mothers

If you fall into any of these categories, it’s essential to discuss the risks and benefits of piroxicam use with your healthcare provider. They may recommend alternative treatments or additional monitoring while using the medication.

How does age affect the risk of side effects with piroxicam? Elderly patients (over 65 years old) are at higher risk of experiencing serious side effects from piroxicam, particularly gastrointestinal bleeding and cardiovascular events. This increased risk is due to age-related changes in drug metabolism and the higher likelihood of comorbid conditions. Healthcare providers may recommend lower doses or alternative treatments for older patients.

Alternatives to Piroxicam: Exploring Other Treatment Options

While piroxicam can be effective for many patients, it’s not the only option for managing arthritis symptoms. Depending on your specific condition and risk factors, your healthcare provider may recommend alternative treatments, such as:

Other NSAIDs (e.g., ibuprofen, naproxen, celecoxib)
Acetaminophen (paracetamol)
Topical pain relievers
Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis
Corticosteroid injections
Physical therapy and exercise
Lifestyle modifications (e.g., weight loss, dietary changes)

The choice of treatment will depend on various factors, including the type and severity of arthritis, individual response to different medications, and overall health status.

What non-pharmacological approaches can help manage arthritis symptoms? In addition to medication, several non-pharmacological approaches can help manage arthritis symptoms and improve quality of life. These include regular exercise, maintaining a healthy weight, using hot or cold therapy, practicing stress-reduction techniques, and utilizing assistive devices when necessary. Many patients find that a combination of pharmacological and non-pharmacological treatments provides the best symptom relief.

Monitoring and Follow-up: Ensuring Safe Long-term Use of Piroxicam

If you’re prescribed piroxicam for long-term use, regular monitoring is essential to ensure its continued safety and effectiveness. Your healthcare provider may recommend:

Periodic blood tests to check kidney and liver function
Regular blood pressure checks
Monitoring for signs of gastrointestinal bleeding
Assessing cardiovascular risk factors
Evaluating the medication’s effectiveness in managing your symptoms

It’s important to attend all follow-up appointments and report any new or worsening symptoms to your healthcare provider promptly.

How often should patients on long-term piroxicam therapy be monitored? The frequency of monitoring will depend on individual factors, including age, overall health, and the presence of any risk factors. Generally, patients on long-term NSAID therapy should have their kidney and liver function checked at least annually, with more frequent monitoring for those at higher risk of complications. Your healthcare provider will determine the appropriate monitoring schedule based on your specific situation.

Side Effects, Dosage, Uses, and More

Highlights for piroxicam

Piroxicam oral capsule is available as a brand-name drug and a generic drug. Brand name: Feldene.
Piroxicam comes only as a capsule you take by mouth.
Piroxicam oral capsule is used to treat rheumatoid arthritis and osteoarthritis.

FDA warning

This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.
Heart disease risk warning: Piroxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of serious heart-related problems, such as heart attack and stroke. Your risk may be higher if you’re taking this drug long term or at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
Warning about ulcers and stomach bleeding that can result in death: Piroxicam can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. These conditions can be fatal. You’re at higher risk of these problems if you’re older than 65 years.
Coronary artery bypass graft surgery warning: Don’t take piroxicam for pain after coronary artery bypass graft surgery. Doing so may increase your risk of a heart attack or stroke.

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Other warnings

High blood pressure warning: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking this drug.
Water retention and swelling warning: If you have water retention issues or heart problems, watch for symptoms of water retention when taking piroxicam.
Asthma warning: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, don’t take piroxicam. It could also trigger an asthma attack.

Piroxicam is a prescription drug. It comes only as an oral capsule.

Piroxicam is available as the brand-name drug Feldene. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Why it’s used

Piroxicam is used to treat symptoms of osteoarthritis and rheumatoid arthritis.

How it works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Piroxicam oral capsule doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects that can occur with piroxicam include:

diarrhea
dizziness
headache
heartburn

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Allergic reaction. Symptoms can include:

skin rash
itching or hives
swelling of your face, lips, or tongue

Heart attack or stroke. Symptoms can include:

chest pain
shortness of breath
weakness on one side of your body
slurred speech

Kidney damage. Symptoms can include:

decreased urination
swelling in your arms, legs, hands, or feet

Heart failure. Symptoms can include:

unusual weight gain
swelling in your arms, legs, hands, or feet

Stomach problems, such as ulcers and bleeding. Symptoms can include:

stomach pain or upset stomach
black, tarry stools
vomiting blood

Liver problems. Symptoms can include:

yellowing of your skin or the whites of your eyes
flu-like symptoms, such as body aches, fever, nausea, and vomiting
tiredness
pain in the upper part of your stomach
itching

Skin reactions. Symptoms can include:

reddening, blistering, or peeling skin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Piroxicam oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with piroxicam are listed below.

Nonsteroidal anti-inflammatory drugs

Taking piroxicam with other NSAIDs may increase side effects, including stomach pain. Examples of other NSAIDs include:

aspirin
ibuprofen
naproxen

Disease-modifying anti-inflammatory drug

Taking methotrexate with piroxicam can lead to dangerous levels of methotrexate in your body. This may cause side effects such as nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs

Taking certain blood pressure drugs with piroxicam might make those drugs not work as well. Examples of these drugs include:

angiotensin-converting enzyme (ACE) inhibitors
diuretics (water pills)

Anticoagulant/blood thinner

Taking warfarin with piroxicam increases your risk of stomach and intestinal bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Piroxicam can cause a severe allergic reaction. Symptoms may include:

shortness of breath or trouble breathing
chest pain
weakness in one part or side of your body
trouble speaking
swelling of your face or throat

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interactions warning

Combining piroxicam and alcohol increases your risk of ulcer or stomach bleeding.

Warnings for people with certain health conditions

For people with asthma: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use piroxicam. It may have the same effect as aspirin.

For people with stomach ulcers or bleeding: This medication increases your risk of bleeding, ulcers, and tears (perforation) in the esophagus, stomach, and intestines. If you have a history of ulcers or stomach or intestinal bleeding and take piroxicam, watch for symptoms of these conditions. Symptoms include stomach pain, black, tarry stools, and vomiting blood. You’re at higher risk if you smoke, use alcohol, or are older than 65 years. Other factors that can increase your risk of bleeding include smoking and taking piroxicam with certain other medications, including antiplatelet drugs (such as aspirin), corticosteroids, selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors.

For people with kidney disease: Piroxicam can cause kidney damage if you use it for a long time. If you have serious kidney disease, you shouldn’t use this drug.

For people with high blood pressure: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

Warnings for other groups

For pregnant women: Piroxicam is a category C pregnancy drug. That means two things:

Research in animals has shown adverse effects to the fetus when the mother takes the drug.
There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking piroxicam during your third trimester of pregnancy. It may harm your pregnancy.

Talk to your doctor if you’re pregnant or planning to become pregnant.

For women who are breastfeeding: Piroxicam passes through breast milk and may cause side effects in a child who is breastfed. It’s not recommended to breastfeed while taking this medication.

For seniors: If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dosage so that too much of the drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

For children: The safety and effectiveness of piroxicam haven’t been established in children younger than 18 years.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

your age
the condition being treated
how severe your condition is
other medical conditions you have
how you react to the first dose

Drug forms and strengths

Generic: Piroxicam

Form: oral capsule
Strengths: 10 mg and 20 mg

Brand: Feldene

Form: oral capsule
Strengths: 10 mg and 20 mg

Dosage for osteoarthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children than 18 years hasn’t been established.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Piroxicam oral capsule is used for short-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop or miss doses: If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If you take too much: If you take too much piroxicam, you may experience:

fatigue
drowsiness
nausea
vomiting
stomach pain
stomach bleeding

In rare cases, taking too much can cause dangerous allergic reactions, high blood pressure, kidney failure, trouble breathing, or coma.

If you think you’ve taken too much of this drug, call your doctor or local poison control center.

If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until your next dose, wait and take a single dose at the usual time. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have reduced arthritis pain.

Keep these considerations in mind if your doctor prescribes piroxicam for you.

General

You can take piroxicam with food to reduce stomach irritation.
This is an oral capsule, so it shouldn’t be cut or crushed.

Storage

Store this drug at a temperature between 59°F and 86°F (15°C and 30°C).
Keep the container tightly closed.
Protect this medication from light.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
Don’t worry about airport X-ray machines. They can’t harm your medication.
You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do tests to check your health and make sure this drug is working for you. These tests include:

blood test
kidney function test
liver function test

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Side Effects, Dosage, Uses, and More

Highlights for piroxicam

Piroxicam oral capsule is available as a brand-name drug and a generic drug. Brand name: Feldene.
Piroxicam comes only as a capsule you take by mouth.
Piroxicam oral capsule is used to treat rheumatoid arthritis and osteoarthritis.

FDA warning

This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.
Heart disease risk warning: Piroxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of serious heart-related problems, such as heart attack and stroke. Your risk may be higher if you’re taking this drug long term or at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
Warning about ulcers and stomach bleeding that can result in death: Piroxicam can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. These conditions can be fatal. You’re at higher risk of these problems if you’re older than 65 years.
Coronary artery bypass graft surgery warning: Don’t take piroxicam for pain after coronary artery bypass graft surgery. Doing so may increase your risk of a heart attack or stroke.

Was this helpful?

Other warnings

High blood pressure warning: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking this drug.
Water retention and swelling warning: If you have water retention issues or heart problems, watch for symptoms of water retention when taking piroxicam.
Asthma warning: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, don’t take piroxicam. It could also trigger an asthma attack.

Piroxicam is a prescription drug. It comes only as an oral capsule.

Why it’s used

Piroxicam is used to treat symptoms of osteoarthritis and rheumatoid arthritis.

How it works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Piroxicam oral capsule doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects that can occur with piroxicam include:

diarrhea
dizziness
headache
heartburn

Serious side effects

Allergic reaction. Symptoms can include:

skin rash
itching or hives
swelling of your face, lips, or tongue

Heart attack or stroke. Symptoms can include:

chest pain
shortness of breath
weakness on one side of your body
slurred speech

Kidney damage. Symptoms can include:

decreased urination
swelling in your arms, legs, hands, or feet

Heart failure. Symptoms can include:

unusual weight gain
swelling in your arms, legs, hands, or feet

Stomach problems, such as ulcers and bleeding. Symptoms can include:

stomach pain or upset stomach
black, tarry stools
vomiting blood

Liver problems. Symptoms can include:

yellowing of your skin or the whites of your eyes
flu-like symptoms, such as body aches, fever, nausea, and vomiting
tiredness
pain in the upper part of your stomach
itching

Skin reactions. Symptoms can include:

reddening, blistering, or peeling skin

Examples of drugs that can cause interactions with piroxicam are listed below.

Nonsteroidal anti-inflammatory drugs

Taking piroxicam with other NSAIDs may increase side effects, including stomach pain. Examples of other NSAIDs include:

aspirin
ibuprofen
naproxen

Disease-modifying anti-inflammatory drug

Taking methotrexate with piroxicam can lead to dangerous levels of methotrexate in your body. This may cause side effects such as nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs

Taking certain blood pressure drugs with piroxicam might make those drugs not work as well. Examples of these drugs include:

angiotensin-converting enzyme (ACE) inhibitors
diuretics (water pills)

Anticoagulant/blood thinner

Taking warfarin with piroxicam increases your risk of stomach and intestinal bleeding.

This drug comes with several warnings.

Allergy warning

Piroxicam can cause a severe allergic reaction. Symptoms may include:

shortness of breath or trouble breathing
chest pain
weakness in one part or side of your body
trouble speaking
swelling of your face or throat

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interactions warning

Combining piroxicam and alcohol increases your risk of ulcer or stomach bleeding.

Warnings for people with certain health conditions

For people with asthma: Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use piroxicam. It may have the same effect as aspirin.

For people with kidney disease: Piroxicam can cause kidney damage if you use it for a long time. If you have serious kidney disease, you shouldn’t use this drug.

For people with high blood pressure: Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

Warnings for other groups

For pregnant women: Piroxicam is a category C pregnancy drug. That means two things:

Research in animals has shown adverse effects to the fetus when the mother takes the drug.
There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking piroxicam during your third trimester of pregnancy. It may harm your pregnancy.

Talk to your doctor if you’re pregnant or planning to become pregnant.

For women who are breastfeeding: Piroxicam passes through breast milk and may cause side effects in a child who is breastfed. It’s not recommended to breastfeed while taking this medication.

For children: The safety and effectiveness of piroxicam haven’t been established in children younger than 18 years.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

your age
the condition being treated
how severe your condition is
other medical conditions you have
how you react to the first dose

Drug forms and strengths

Generic: Piroxicam

Form: oral capsule
Strengths: 10 mg and 20 mg

Brand: Feldene

Form: oral capsule
Strengths: 10 mg and 20 mg

Dosage for osteoarthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children than 18 years hasn’t been established.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

The typical dosage is 20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child dosage (ages 0-17 years)

Dosage for children younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Piroxicam oral capsule is used for short-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop or miss doses: If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If you take too much: If you take too much piroxicam, you may experience:

fatigue
drowsiness
nausea
vomiting
stomach pain
stomach bleeding

In rare cases, taking too much can cause dangerous allergic reactions, high blood pressure, kidney failure, trouble breathing, or coma.

If you think you’ve taken too much of this drug, call your doctor or local poison control center.

If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You should have reduced arthritis pain.

Keep these considerations in mind if your doctor prescribes piroxicam for you.

General

You can take piroxicam with food to reduce stomach irritation.
This is an oral capsule, so it shouldn’t be cut or crushed.

Storage

Store this drug at a temperature between 59°F and 86°F (15°C and 30°C).
Keep the container tightly closed.
Protect this medication from light.

Refills

Travel

When traveling with your medication:

Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
Don’t worry about airport X-ray machines. They can’t harm your medication.
You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do tests to check your health and make sure this drug is working for you. These tests include:

blood test
kidney function test
liver function test

Prior authorization

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Interaction of Piroxicam-obl with other drugs

Learn about the interaction of Piroxicam-obl with other drugs, its side effects and rules of use. Piroxicam-obl is an effective anti-inflammatory drug that can be prescribed by a doctor for the treatment of various diseases. Before using the drug, it is necessary to familiarize yourself with information about its interaction with other drugs in order to avoid undesirable consequences and maximize the effectiveness of treatment.

Piroxicam is an effective anti-inflammatory drug that is often prescribed for the treatment of various diseases of the musculoskeletal system. However, before you start taking this drug, you must consider its interaction with other drugs.

It is important to remember that the simultaneous use of Piroxicam with other anti-inflammatory drugs may increase their action, which can lead to an increased risk of side effects.

In addition, while taking Piroxicam-reg with anticoagulants (drugs that reduce blood clotting), it is possible to increase their effect and increase the risk of bleeding.

It is important to note that with the simultaneous use of Piroxicam-reg with diuretics (drugs that increase the excretion of fluid from the body), water and electrolyte imbalance may occur.

Before you start taking Piroxicam-reg, you should consult with your doctor, who can assess the possible risks and side effects when taken with other drugs.

Drugs that affect the effectiveness of Piroxicam-reg

When Piroxicam-reg is used simultaneously with some other drugs, interactions may occur, as a result of which its effectiveness may change.

One of the drugs that affect the effectiveness of Piroxicam-reg is agents that have a negative effect on kidney function. Interaction with such drugs can lead to deterioration of kidney function and increased side effects of Piroxicam-reg.

The interaction of Piroxicam with anticoagulants (drugs that increase blood clotting) should also be taken into account, as this may lead to an increased risk of bleeding.

The simultaneous use of Piroxicam with other anti-inflammatory drugs is not recommended, as this may increase the risk of unwanted side effects and complications.

It is important to note that this information is not exhaustive, and before starting treatment with Piroxicam, you should consult your doctor and clarify possible interactions with other drugs.

Drugs that enhance the effect of Piroxicam-reg

Piroxicam-reg can be effectively enhanced when used simultaneously with other drugs. Some of them can increase the effectiveness and speed of action of Piroxicam-reg, which allows you to achieve faster pain relief and recovery of health.

One of the drugs that enhance the effect of Piroxicam-region is the analgesic Nimesulide. This drug has an analgesic and anti-inflammatory effect, which complements the action of Piroxicam-reg. Taking these medications in combination can greatly enhance pain relief and reduce inflammation.

Another drug that has shown good results in combination with Piroxicam is the glucocorticosteroid Prednisolone. This drug has a powerful anti-inflammatory effect and can enhance the effect of Piroxicam-reg, accelerating pain relief and recovery of health.

It is also worth noting the drug Meloxicam, which has a similar mechanism of action to Piroxicam-reg. Taking these drugs in combination can increase pain relief and reduce inflammation, allowing for faster recovery.

It is important to remember that before taking any medicines, including drugs that enhance the effect of Piroxicam-reg, you should consult your doctor and strictly follow the recommendations for dosage and regimen. Misuse of medications can lead to unwanted side effects and poor health.

Drugs that reduce the effectiveness Piroxicam-reg

Piroxicam-reg is an effective anti-inflammatory and analgesic drug that is widely used in medicine. However, there are some drugs that can reduce its effectiveness and reduce the desired therapeutic effect.

First of all, it is not recommended to combine Piroxicam-reg with other non-steroidal anti-inflammatory drugs such as Ibuprofen, Naproxen, Diclofenac, etc. This is due to the fact that all these drugs act on the same group of enzymes and can interact with each other, which will lead to a decrease in the effectiveness of Piroxicam-reg.

The concomitant use of Piroxicam with acetylsalicylic acid (aspirin) should also be avoided as this may increase the risk of side effects such as bleeding and stomach ulcers.

It is important to note that Piroxicam may increase the effects of anticoagulants (blood thinners), so you should be especially careful and consult your doctor if you are taking such medications.

In general, it is recommended that you consult your doctor or pharmacist before taking Piroxicam or any other medicines to avoid unwanted interactions and maximize the effectiveness of your treatment.

Drugs that interact with Piroxicam in the liver

Piroxicam is an anti-inflammatory and analgesic drug that is extensively metabolized in the liver. In this regard, there are a number of drugs that can affect its processing and effectiveness. The following is a list of drugs that interact with Piroxicam-reg in the liver:

Acetylsalicylic acid: The use of Piroxicam-reg together with acetylsalicylic acid may increase the risk of bleeding and ulcerative lesions of the gastrointestinal tract.
Methotrexate: Simultaneous use of Piroxicam-reg and methotrexate may increase the toxicity of the latter, especially to the liver.
Lithium: Simultaneous use of Piroxicam-obl and lithium may cause an increase in the concentration of lithium in the blood, which can lead to toxic effects.
Furosemide: Furosemide may reduce the effectiveness of Piroxicam-reg, because it reduces its plasma concentration.

It is important to remember that this is not a complete list of drugs that interact with Piroxicam in the liver. Before you start taking any medicines, including Piroxicam-reg, you should consult your doctor or pharmacist to avoid possible negative consequences.

Drugs that interact with Piroxicam-reg in the kidneys

Piroxicam-reg is a drug that is used to relieve pain and inflammation. However, when using it, it is necessary to take into account possible interactions with other drugs, especially with kidney damage.

Diuretics : Interactions with Piroxicam-reg can lead to a decrease in the effectiveness of diuretics, which can lead to fluid retention in the body and deterioration of kidney function. With the simultaneous use of these drugs, it is necessary to monitor the level of electrolytes in the blood and kidney function.

Anti-inflammatory and analgesic drugs : The combined use of Piroxicam-reg with other anti-inflammatory and analgesic drugs may increase the risk of side effects, especially on the kidneys. If you need a combined use, you should consult a doctor and monitor kidney function.

Antihypertensive drugs : Piroxicam may reduce the effectiveness of antihypertensive drugs, which can lead to an increase in blood pressure. With simultaneous use, it is necessary to regularly monitor blood pressure and, if necessary, adjust the dosage of antihypertensive drugs.

Anticoagulants : Piroxicam may increase the effect of anticoagulants, which may increase the risk of bleeding. With simultaneous use, it is necessary to control blood clotting and, if necessary, adjust the dosage of anticoagulants.

It is important to remember that this information is not exhaustive, and before starting the use of Piroxicam or combined treatment, you should consult your doctor and read the instructions for use.

Drugs that interact with Piroxicam-reg in the blood

When using the drug Piroxicam-reg, it is necessary to take into account its possible interaction with other drugs. Some drugs may affect the blood concentration of Piroxicam, which may cause unwanted effects or reduce its effectiveness.

Interactions of Piroxicam with acetylsalicylic acid (aspirin) may increase the risk of bleeding. Therefore, with the simultaneous use of these drugs, it is necessary to be especially careful and monitor the state of bleeding.

Some antiplatelet agents, such as cardioaspirin and clofibrate, may also increase the effect of Piroxicam and increase the risk of bleeding. When combining these drugs, it is necessary to carefully monitor the patient’s condition and, if necessary, adjust the dosage.

Preparations containing glucocorticosteroids (eg prednisolone) may also increase the effect of Piroxicam and increase the risk of erosive ulcerative lesions of the gastrointestinal tract. With the simultaneous use of these drugs, it is necessary to be especially careful and monitor the patient’s condition.

Interaction of Piroxicam with anticoagulants (eg warfarin) may increase their effect and increase the risk of bleeding. With the combination of these drugs, it is necessary to regularly monitor blood coagulability and, if necessary, adjust the dosage.

Some drugs, such as lithium and methotrexate, may increase the renal toxicity of Piroxicam. With the simultaneous use of these drugs, it is necessary to regularly monitor kidney function and, if necessary, adjust the dosage.

Piroxicam may decrease the effectiveness of diuretics such as furosemide. With the combination of these drugs, it is necessary to control diuresis and, if necessary, adjust the dosage of the diuretic.

Preparations containing magnesium, aluminum or calcium may reduce the absorption of Piroxicam and reduce its effectiveness. With the simultaneous use of these drugs, it is necessary to observe an interval of 2 hours between taking Piroxicam-reg and drugs containing these microelements.

Drugs that interact with Piroxicam-reg in the gastrointestinal tract

Piroxicam-reg is a drug that is widely used to treat various inflammatory diseases. However, when using it, it is necessary to take into account the possible interaction with other drugs, especially in the gastrointestinal tract.

Interaction of Piroxicam-reg with some drugs may lead to an increase or decrease in its effect. For example, concomitant use with anticoagulants (drugs that reduce blood clotting) may increase the risk of bleeding.

Caution should also be exercised when Piroxicam is used in combination with other anti-inflammatory drugs, as this may increase the risk of side effects, especially on the gastrointestinal tract.

It is important to remember that the interaction of Piroxicam with other drugs can be individual and depends on many factors, including dosage and duration of drug administration. Therefore, before starting treatment, it is necessary to consult a doctor and inform about all medications taken.

In general, when used correctly and following the doctor’s recommendations, Piroxicam is an effective drug for the treatment of inflammatory diseases. However, it is necessary to be careful and cautious when it is combined with other drugs, especially in the gastrointestinal tract.

Drugs that affect the pharmacokinetics Piroxicam-reg

Piroxicam-reg is an effective anti-inflammatory and analgesic drug, which is often used to treat various diseases of the musculoskeletal system. However, it is worth remembering that the interaction of Piroxicam with some other drugs can affect its pharmacokinetics.

One such drug is acetylsalicylic acid, which can enhance the effects of Piroxicam and increase the risk of side effects, especially on the digestive system. Therefore, with the simultaneous use of these drugs, it is necessary to be especially careful and consult a doctor.

Another drug that can affect the pharmacokinetics of Piroxicam is lithium salts. They can increase the toxic effect of Piroxicam-region on the kidneys, therefore, with the simultaneous use of these drugs, it is necessary to regularly monitor kidney function and monitor the level of lithium in the blood.

It should also be noted that the simultaneous use of Piroxicam-reg with diuretics can lead to an increase in their diuretic effect and an increased risk of kidney complications. Therefore, with the combined use of these drugs, it is necessary to regularly monitor kidney function and monitor the level of electrolytes in the blood.

It is important to remember that the interaction of Piroxicam with other drugs can be individual and depends on many factors, including dosage, duration of administration and the characteristics of the patient’s body. Therefore, before starting treatment with Piroxicam-Oblom, it is necessary to consult a doctor and inform about all medications taken.

Q&A:

Can Piroxicam-reg be taken with aspirin?

Yes, you can take Piroxicam with aspirin, but care must be taken as this may increase the risk of gastrointestinal side effects.

Can Piroxicam be taken with antibiotics?

Yes, you can usually take Piroxicam with antibiotics, but you should consult your doctor or pharmacist before starting the combination to avoid possible interactions and side effects.

Can Piroxicam-reg be taken with high blood pressure medicines?

No, it is not recommended to take Piroxicam with high blood pressure medications without first consulting a doctor, as this may increase the effect of high blood pressure medications and lead to serious side effects.

Can Piroxicam-reg be taken with diabetes medications?

Yes, in most cases you can take Piroxicam with your diabetes medications, but you should consult your doctor or pharmacist before starting the combination to avoid possible interactions and side effects.

Can I take Piroxicam with allergy medications?

Yes, you can usually take Piroxicam with allergy medications, but you should consult your doctor or pharmacist before taking it in combination to avoid possible interactions and side effects.

Can Piroxicam-reg be taken with gastritis drugs?

Yes, it is possible to take Piroxicam with gastritis medications, but care must be taken as this may increase the risk of gastrointestinal side effects.

Can Piroxicam obl be taken with headache medications?

Yes, Piroxicam-reg can be taken with anticoagulants, but this may increase the risk of bleeding. Therefore, it is necessary to consult a doctor before taking these drugs at the same time.

Can Piroxicam-reg be taken with aspirin?

Yes, Piroxicam can be taken with aspirin, but this may increase the risk of side effects such as bleeding or stomach ulcers. It is recommended that you consult your doctor before taking these drugs at the same time.

Can Piroxicam be taken with antibiotics?

Yes, Piroxicam-reg can be taken with antibiotics. However, some antibiotics may interact with Piroxicam and increase its side effects. Therefore, if you experience any side effects, you should consult your doctor.

Can Piroxicam-reg be taken with antifungal drugs?

Yes, in most cases Piroxicam can be taken with an antifungal medication. However, some antifungal medications may interact with Piroxicam and increase its side effects. It is recommended that you consult your doctor before taking these drugs at the same time.

Can I take Piroxicam-reg with medicines for high blood pressure?

Yes, Piroxicam-reg can be taken with high blood pressure medications. However, some high blood pressure medications may interact with Piroxicam and reduce its effectiveness or increase its side effects. It is recommended that you consult your doctor before taking these drugs at the same time.

Non-steroidal anti-inflammatory drugs – NCCH

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of non-hormonal anti-inflammatory drugs.

The drugs listed below are most commonly used in pediatric practice.

Aspirin, analgin, diclofenac, ibuprofen, ketoprofen, napraxen, piroxicam, meloxicam, nimesulide

Available in tablets, capsules, injection solutions, ointments, gels, suppositories (candles).

What are NSAIDs and how do they work?

NSAIDs have anti-inflammatory, analgesic and antipyretic effects. The main mechanism of action is inhibition of the formation of prostaglandins. Prostaglandins are tissue hormones that promote inflammation and the pain that accompanies it.

What are non-steroidal anti-inflammatory drugs used for?

Preparations are designed to relieve pain of various nature.

Non-steroidal anti-inflammatory drugs are indicated for inflammatory diseases of the joints (rheumatoid arthritis, rheumatism, ankylosing spondylitis, chronic gouty arthritis), degenerative diseases (deforming osteoarthrosis, osteochondrosis), lumbago, sciatica, neuralgia, myalgia, diseases of extra-articular tissues (tendovaginitis, bursitis, rheumatic soft tissue lesions), post-traumatic pain syndrome accompanied by inflammation, postoperative pain, acute attack of gout, migraine attacks, renal and hepatic colic, infections of the upper respiratory tract, residual effects of pneumonia. Locally – injuries of tendons, ligaments, muscles and joints (to relieve pain and inflammation during sprains, dislocations, bruises), localized forms of soft tissue rheumatism (elimination of pain and inflammation).

What should I tell my doctor before starting treatment with non-steroidal anti-inflammatory drugs?

O the patient has gastric and/or duodenal ulcer
About the presence of a chronic kidney or liver disease in a patient
Patient has ever had a reaction to salicylates or any other drug
That the patient is taking any other medications, including over-the-counter drugs, vitamins
Pregnancy or lactation

What are the rules for taking non-steroidal anti-inflammatory drugs?

Take this medicine as directed by your doctor.
NSAIDs are taken 1-2 hours after meals with plenty of water
Never take more non-steroidal anti-inflammatory drugs (NSAIDs) than prescribed by your doctor. If you have taken an excessive dose, contact your doctor immediately or call an ambulance.
During treatment, carry the package of the medicine with you, keep a constant supply of the drug.
This medicine has been prescribed for you only. Never give it to other people, even if you think they have the same disease.
With long-term use of non-steroidal anti-inflammatory drugs, regular monitoring of parameters reflecting the function of the liver, kidneys, as well as peripheral blood parameters should be carried out.

What if you miss a dose?

Take the missed dose as soon as you remember.
If you miss a dose and it’s already time for your next dose, continue taking your non-steroidal anti-inflammatory drugs as usual.
Do not take a double or extra dose of the drug.

What is needed to make the treatment effective and safe?

Visit your doctor regularly to evaluate the effectiveness of your treatment.