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Podofilox solution side effects: Podofilox (Topical Route) Side Effects

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Podofilox (Topical Route) Side Effects

Side Effects

Drug information provided by: IBM Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

  1. Bad odor (solution only)

  2. bleeding of treated skin

  3. blistering, crusting, or scabbing of treated skin

  4. bloody urine (solution only)

  5. burning feeling of treated skin

  6. dizziness (solution only)

  7. headache (gel only)

  8. itching of treated skin

  9. pain during sexual intercourse (solution only)

  10. pain of treated skin

  11. problems with foreskin of penis (solution only)

  12. redness or swelling of treated skin

  13. scarring of treated skin (solution only)

  14. skin ulcers of treated skin

  15. vomiting (solution only)
Symptoms of overdose

  1. Nausea

  2. vomiting

  3. diarrhea

  4. chills

  5. fever

  6. sore throat

  7. unusual bleeding or bruising

  8. oral ulcers

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Dryness of treated skin

  2. peeling of treated skin

  3. soreness or tenderness of treated skin

  4. stinging or tingling of treated skin

  5. trouble in sleeping (solution only)
Less common

  1. Changes in color of treated skin (gel only)

  2. skin rash (gel only)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Feb. 01, 2021

Copyright © 2021 IBM Watson Health. All rights reserved. Information is for End User’s use only and may not be sold, redistributed or otherwise used for commercial purposes.


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Podofilox Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Read the Patient Information Leaflet available from your pharmacist before you start using podofilox solution and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is for use on the skin only. Only apply this medication to the genital warts that your doctor has identified for you. Do not use this medication on warts around the anus or on the mucous membranes (such as in the urethra, rectum, and vagina), inside your body, or on any other skin growths.

Use this medication usually twice daily (once in the morning and once in the evening, every 12 hours), for 3 days in a row, followed by no treatment for the next 4 days. If the warts do not go away, you may repeat this 7-day cycle up to a total of 4 treatment weeks in a row. Follow your doctor’s directions exactly.

First wash the area to be treated with soap and water, and dry thoroughly. Use an applicator that comes with this product, dip it into the solution just enough to wet it, but not so much that solution is dripping from the tip. Apply this medication only to the warts your doctor has directed you to treat. Do not apply it to the area surrounding the warts. It may help to use a hand mirror.

For warts within skin folds, pull the skin fold open and apply the medication. Let the medication dry before allowing the skin folds around the warts to return to their normal position.

Only use the applicator once. Do not dip it into the solution again. Throw it away in a safe place after use. Wash your hands with soap and water after each application.

Do not cover the treated area with bandages or other waterproof dressings. Covering the area with cotton gauze, or cotton underwear for the genital area, is permitted.

Use this medication regularly to get the most benefit from it. To help you remember, use a calendar to mark the days you will be applying the medication each week.

Avoid getting this medication in the eyes/nose/mouth, on healthy skin, or on other areas as mentioned above. If the medication gets on healthy skin, wipe it off right away and wash the area thoroughly with soap and water and rinse off. If the medication gets in your eyes, nose, or mouth, flush the area with plenty of water for 15 minutes and contact your doctor.

Do not apply a large amount of this medication or apply it to a large area. Ask your doctor or pharmacist for details. Do not use it more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition persists after 4 weeks of treatment, or if it worsens, or if new growths appear during treatment. Genital warts often return after treatment.

Podofilox topical solution

What is this medicine?

PODOFILOX (po do FIL ox) is a medication used to remove genital warts. The topical solution should only be used to treat genital warts located on the outside skin of the genitals (i.e., penis or vagina). The solution should not be used to treat warts near the rectal area.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Condylox

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to podofilox, podophyllum resin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for external use only on the skin. Do not take by mouth. The solution may be used on the outside (external) areas of the skin around the vagina or penis to remove warts. The solution should not be used in the area between the rectum and the genitals. The solution should only be used on the outside skin. It should not be used to treat warts that are inside the rectum, vagina, or penis. Do not use this medicine more often or for longer than directed. Do not use a larger dose than directed by your health care professional.

Wash hands before and after use. Read package directions carefully before using. Apply the medication to the specific wart as instructed by your physician. Apply the solution using the applicator provided or a cotton-tipped applicator. Applicators should not be re-used. Additionally, used applicators should not be dipped into the bottle to prevent contamination. After application, you should make sure that the medication is dry before normal, untreated skin comes into contact with the treated skin. This medicine can cause severe irritation of normal skin. If contact with normal skin occurs, immediately flush the area thoroughly with water.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not use any other medicines on the affected area without asking your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. This medicine is not a cure. New warts may develop during or after treatment.

Tell your doctor or health care professional if your symptoms do not start to get better within one week. The weekly treatment course can be repeated up to 4 times. If the wart does not resolve in 4 weeks, a different treatment should be considered. If you are pregnant or think you might be pregnant, contact your doctor or health care professional.

Sexual (genital, oral, anal) contact should be avoided while the medication is on the skin.

The only way to prevent infecting others with the HPV virus (the virus that causes genital warts) is to avoid direct skin-to-skin contact. If warts are visible in the genital area, sexual contact should be avoided until the warts are treated. Experts advise that using latex condoms during sexual contact may reduce, but not entirely prevent, infecting others.

Avoid contact with the eyes. If eye contact occurs, patients should immediately flush the eye with large quantities of water for 15 minutes and seek medical attention.

This medicine contains alcohol and is flammable. Do not use near heat, open flame, or while smoking.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • bleeding, blistering, burning, crusting, or scabbing of treated skin
  • blood in the urine
  • dizziness
  • severe skin rash or swelling
  • vomiting (may indicate excessive dosage)

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dryness, flaking or peeling of the skin
  • headache
  • mild redness, itching or stinging of the skin

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 to 30 degrees C (59 to 86 degrees F). Do not freeze. Keep container tightly closed. This medicine contains alcohol and is flammable. Do not store near heat or open flame. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Condylox (podofilox) dosing, indications, interactions, adverse effects, and more.

PODOFILOX GEL – TOPICAL

(poe-DOF-il-ox)

COMMON BRAND NAME(S): Condylox

USES: This medication is used on the skin to treat external genital warts.

HOW TO USE: This medication is for topical use only. Apply it on the warts pointed out by your doctor. It is usually applied once in the morning and again in the evening for 3 days followed by a 4 day rest period. If the warts do not go away, then this cycle is repeated up to 4 times. Contact your doctor for other options if the warts do not go away after 4 weeks of treatment.To apply, use the provided applicator tip or your finger. Apply a small amount of medication to the wart to cover it. Allow the gel to dry. Wash your hands thoroughly afterwards. Be careful with this medication because it can irritate normal skin around the application site.Do not use large amounts, apply more often or use for a longer period than directed. Your condition will not clear faster, and the chance for side effects may be increased.Avoid contact with the eyes and mucous membranes. If contact occurs, immediately wash with plenty of water and contact your doctor.Read the Patient Information Leaflet available from your pharmacist. Consult your doctor or pharmacist if you have any questions.

SIDE EFFECTS: Swelling, pain, burning, itching, peeling skin, small sores, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if this serious side effect occurs: bleeding.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking podofilox, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: other skin problems (e.g., skin cancer).This medication must not be used during pregnancy. Women of child-bearing age should use a reliable form of birth control while using this medication. If you become pregnant or think you may be pregnant, inform your doctor right away.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medicine may be harmful if swallowed. If accidentally swallowed, you may experience symptoms such as: nausea, vomiting, diarrhea, change in mental status, weakness or fatigue, unusually slowed breathing, and seizures.

NOTES: This medication is prescribed for your current condition only. Do not use it later for another skin problem unless directed by your doctor. A different medication may be necessary in those cases.Do not share this medication with others.This medication is not a cure. New warts or return of old warts may occur, especially in the first 3 months after treatment. Follow-up medical visits may be periodically necessary to monitor your progress or check for side effects. Consult your doctor for more details.Refrain from sexual intercourse on the days you apply this drug. Using condoms may help prevent the spread of genital warts to your partner.

MISSED DOSE: If you miss a dose, apply it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat or open flame. Do not freeze. Replace the cap tightly after use. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

PODOFILOX | Healthgrades | (solution)

Brand Name: PODOFILOX

Generic Name: PODOFILOX

Drug Type: HUMAN PRESCRIPTION DRUG

Route: TOPICAL

Dosage Form: SOLUTION

Data Current As Of: 2018-11-15

Podofilox Topical Solution 0.5% is indicated for the topical treatment of external genital warts (Condyloma acuminatum). This product is not indicated in the treatment of perianal or mucous membrane warts (see PRECAUTIONS ).

Although genital warts have a characteristic appearance, histopathologic confirmation should be obtained if there is any doubt of the diagnosis. Differentiating warts from squamous cell carcinoma (so-called “Bowenoid papulosis”) is of particular concern. Squamous cell carcinoma may also be associated with human papillomavirus but should not be treated with Podofilox Topical Solution 0. 5%.

Podofilox Topical Solution 0.5% is contraindicated for patients who develop hypersensitivity or intolerance to any component of the formulation.

In clinical trials, the following local adverse reactions were reported at some point during treatment.

Adverse Experience Males Females

Burning

64%

78%

Pain

50%

72%

Inflammation

71%

63%

Erosion

67%

67%

Itching

50%

65%

Reports of burning and pain were more frequent and of greater severity in women than in men.

Adverse effects reported in less than 5% of the patients included pain with intercourse, insomnia, tingling, bleeding, tenderness, chafing, malodor, dizziness, scarring, vesicle formation, crusting edema, dryness/peeling, foreskin irretraction, hematuria, vomiting and ulceration.

Manufactured By

Perrigo ®

Minneapolis, MN 55427

2124159

(05-12)

PODOFILOX TOPICAL SOLUTION 0.5% AND GENITAL WARTS

  • 1.APPLY PODOFILOX TOPICAL SOLUTION ONLY ON THE WARTS POINTED OUT BY YOUR DOCTOR.
  • 2.STOP TREATMENT AND CALL YOUR DOCTOR IF YOU HAVE BLEEDING, SWELLING, OR EXCESSIVE PAIN, BURNING, OR ITCHING.
  • 3.DO NOT USE MORE THAN TWO TIMES A DAY.
  • 4.DO NOT USE FOR MORE THAN THREE DAYS IN A ROW.
  • 5.DO NOT HAVE SEXUAL INTERCOURSE ON THE DAYS YOU ARE APPLYING PODOFILOX TOPICAL SOLUTION.
  • 6.WASH HANDS AFTER EVERY USE.

INTRODUCTION

Podofilox Topical Solution slowly kills external genital warts. The warts will change from a fleshy skin color to a dry, crusted, dead look, then disappear. Three out of four patients feel some burning or pain after they apply Podofilox Topical Solution. Other side effects may include redness, soreness, tenderness, and small sores. These usually go away within a week after Podofilox Topical Solution is stopped. If pain or other side effects bother you too much, stop applying Podofilox Topical Solution and contact your doctor.

HOW TO USE PODOFILOX TOPICAL SOLUTION

Follow these and your doctor’s instructions carefully. Apply Podofilox Topical Solution only on the warts pointed out by your doctor. Do not use it on any other warts on or inside your body, or for any other skin growth.

  • 1.Open the bottle and put it on a flat surface. Hold the bottle and dip the applicator tip into the liquid. Touch the applicator tip against the inside edge of the bottle so the applicator is wet with no liquid dripping. Make sure to close the bottle tightly after use.

APPLY PODOFILOX TOPICAL SOLUTION ONLY WHERE YOUR DOCTOR HAS INSTRUCTED YOU

  • 2.Apply Podofilox Topical Solution to the wart. Do not get it on normal skin. If a wart is in a skin fold, spread the skin apart so you can reach the wart. A hand mirror can help sometimes. Let Podofilox Topical Solution dry before letting the skin folds return to their normal position. Wash your hands well with soap and water after you use Podofilox Topical Solution.
  • 3.Apply Podofilox Topical Solution once in the morning and once in the evening for three days in a row. Then stop applying Podofilox Topical Solution and wait four days. Using Podofilox Topical Solution like this is called a treatment week.There is no need to wash Podofilox Topical Solution off the wart area.

DO NOT APPLY PODOFILOX TOPICAL SOLUTION MORE THAN TWICE EACH DAY OR FOR MORE THAN THREE DAYS IN A ROW. USING PODOFILOX TOPICAL SOLUTION MORE OFTEN WILL NOT MAKE IT WORK BETTER BUT MAY INCREASE SIDE EFFECTS

  • 4.If the warts do not go away, repeat the Podofilox Topical Solution treatment for another week. You can use Podofilox Topical Solution up to four treatment weeks (REMEMBER: a treatment week is twice a day for three days, then four days with no treatment). Your doctor may ask you to come back for a check-up visit during treatment. If the warts have not gone away after four treatment weeks, stop applying Podofilox Topical Solution and contact your doctor.

IF THE AREA YOU ARE PUTTING PODOFILOX TOPICAL SOLUTION ON IS BLEEDING OR SWOLLEN, OR IF THERE IS EXCESSIVE PAIN, BURNING OR ITCHING, STOP APPLYING PODOFILOX TOPICAL SOLUTION AND CONTACT YOUR DOCTOR

  • 5. Genital warts can come back. If your warts come back, contact your doctor.

SPECIAL CAUTIONS

  • Genital warts are contagious. You can give them to or get them from your sexual partner. Make sure your sexual partner has been checked for genital warts. Condoms can help protect both you and your partner. Do not have sexual intercourse for the three days you are applying Podofilox Topical Solution.
  • Women should make sure to use birth control so they will not get pregnant while on Podofilox Topical Solution. The effects on the unborn baby are not known. Women can use Podofilox Topical Solution during their menstrual period.
  • Podofilox Topical Solution is prescribed only for your external genital warts. Do not let anyone else use it.

REMEMBER:

  • Do not use the applicator more than once. Throw it away so it can not infect anyone else.
  • Always wash your hands after using Podofilox Topical Solution.
  • Do not get it in your eyes. If you do, immediately flush your eyes with water and contact your doctor.
  • Keep the bottle tightly closed and store in an upright position.
  • Be sure to keep this and all medications out of the reach of children.

CONTACT YOUR DOCTOR IF YOU HAVE QUESTIONS ABOUT PODOFILOX TOPICAL SOLUTION

Manufactured By

Perrigo®

Minneapolis, MN 55427

2124160

(05-12)

Tips From Other Journals – American Family Physician

Tips from Other Journals

 

Am Fam Physician. 1998 Jul 1;58(1):249.

Anogenital warts (condylomata acuminata) are difficult to treat successfully. The 0.5 percent podofilox solution is approved for self-use and, when used in three-day treatment cycles over a four-week period, appears to be less toxic than podophyllum resin. Previous studies have demonstrated a patient preference for self-treatment of genital warts. The gel was formulated as an easier-to-apply alternative. Tyring and associates performed a double-blind, randomized, vehicle-controlled study of podofilox gel in patients with anogenital warts.

A total of 292 immunocompetent patients were included in the study. The majority of the warts were located on the penile shaft in men and on the labia in women. Approximately 20 percent of the subjects had received previous treatment for warts. During the study period, participants were randomized to receive podofilox gel or vehicle gel. The topical medication was applied twice a day for three consecutive days, followed by four days without treatment (one cycle). Patients used the medication for two to eight treatment cycles.

The 0.5 percent podofilox gel was significantly more effective than vehicle gel for clearing anogenital and external genital warts after four weeks and eight weeks of treatment. Treatment success increased 31 percent (from 62 to 81 patients) with an additional four to eight weeks of podofilox gel therapy. No significant differences in clearance rates in men or women were apparent. Significantly fewer warts remained after active drug therapy. Physician assessment of response to treatment demonstrated that 73.8 percent of the patients treated with 0.5 percent podofilox gel had either moderate or marked improvement or complete clearing of warts after four weeks. At eight weeks, 81.1 percent of the patients treated with podofilox gel had either moderate or complete clearance of warts, compared with 17.2 percent of the patients treated with the vehicle gel. Significantly more patients discontinued treatment with the vehicle gel because of ineffective clearance of warts.

Adverse effects were significantly greater in the active drug group. The most common adverse events were burning, inflammation, itching, erosion, pain and bleeding. Burning was the most frequently reported side effect in the active drug group during the first six weeks. Almost all local adverse effects resolved within four weeks of cessation of treatment. The incidence of inflammation and erosion was significantly greater in men than in women. In women with external warts, the most common adverse event was burning (75.3 percent). For those with perianal warts, the most common local adverse events were burning in women (91.7 percent) and inflammation and pain in men (71.4 percent).

The authors conclude that 0.5 percent podofilox gel was significantly more effective than the vehicle gel in reducing numbers of genital warts (external and perianal) in both men and women. The gel form is easier to apply than the solution and does not have a higher adverse event profile.

Krames Online – Podofilox Topical Solution 0.5%

Uses

For genital warts.

Instructions

DO NOT take this medicine by mouth.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

Only apply this medicine to the warts identified by the doctor. Do not use this medicine on any other warts.

Apply a thin layer of medicine on each wart and do not rub it in. Do not wash area between doses.

Use the applicator to apply the medicine to the affected area.

Follow the instructions on the package to use this medicine correctly.

Discard applicator after use. Do not reuse.

Store in original bottle, tightly closed and upright.

Keep the medicine at room temperature. Avoid heat and direct light.

This medicine should only be used on the skin.

Avoid getting the medicine in the eyes, nose, or mouth. Wash the medicine off your fingers after applying it.

Avoid getting this medicine inside the vagina.

Do not use this medicine inside the rectum.

Let the medicine dry completely before allowing anyone else to touch the area.

Try not to get the medicine on normal-looking skin.

Wash your hands before and after handling this medicine.

Do not touch your eyes, nose or mouth after handling the medicine.

If medicine gets in your eyes, rinse well with cool water.

If medicine gets into the mouth or nose, rinse with water for 15 minutes and then seek medical care right away.

Please tell your doctor and pharmacist about all the medicines you take. Include both prescription and over-the-counter medicines. Also tell them about any vitamins, herbal medicines, or anything else you take for your health.

Do not freeze the medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Symptoms of an allergic reaction can include trouble breathing, skin rash, itching, swelling, or severe dizziness.

Do not use the medication any more than instructed.

Avoid sexual intercourse while on this medicine.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

This medicine can cause birth defects. Speak with your doctor about birth control methods that should be used while on this medicine.

Ask your pharmacist if this medicine can interact with any of your other medicines. Be sure to tell them about all the medicines you take.

Please tell all your doctors and dentists that you are on this medicine before they provide care.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Do not start or stop any other medicines without first speaking to your doctor or pharmacist.

Do not share this medicine with anyone who has not been prescribed this medicine.

Contact your doctor if your symptoms do not improve or worsens after 4 weeks of using this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • burning or stinging
  • itching
  • skin irritation such as redness, itching, rash, or burning
  • skin irritation where medicine is applied

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • blistering or peeling of the skin

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Extra

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

https://krames.meducation.com/V2.0/fdbpem/9193


IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all
there is to know about it.Your doctor or pharmacist may give you other documents about your medicine.
Please talk to them if you have any questions.Always follow their advice. There is a more complete
description of this medicine available in English.Scan this code on your smartphone or tablet or use
the web address below. You can also ask your pharmacist for a printout. If you have
any questions, please ask your pharmacist.


Lidamitol instructions for use: indications, contraindications, side effects – description Lidamitol solution for intravenous and intramuscular administration 100 mg + 2.5 mg / 1 ml: amp. 1 ml 5 or 10 pcs. (55528)

Classification of the incidence of side effects recommended by WHO: very often (≥1 / 10), often (≥1 / 100 and <1/10), infrequently (≥1 / 1000 and <1/100), rarely (≥1 / 10,000 and <1/1000), very rare (<1/10000), frequency unknown (cannot be estimated from available data).

Blood and lymphatic system disorders: very rarely – anemia, lymphadenopathy.

From the immune system: rarely – hypersensitivity reactions, anaphylactic reactions; very rarely – anaphylactic shock.

From the side of metabolism: infrequently – anorexia; very rarely, polydipsia.

Mental disorders: infrequently – insomnia, sleep disorders; rarely – loss of activity, depression.

From the nervous system: infrequently – headache, dizziness, drowsiness; rarely – attention deficit disorder, tremors, seizures, loss of sensitivity, sensory disorders, lethargy.

From the side of the organ of vision: rarely – visual impairment.

On the part of the organ of hearing and labyrinthine disorders: rarely – ringing in the ears, vertigo.

From the side of the heart: rarely – angina pectoris, tachycardia, heart palpitations; very rarely – bradycardia.

From the side of the vessels: infrequently – arterial hypotension; rarely – hot flushes.

Respiratory system: rarely – shortness of breath, epistaxis, rapid breathing.

From the gastrointestinal tract: infrequently – gastrointestinal discomfort, diarrhea, dry mouth, dyspepsia, nausea; rarely – epigastric pain, constipation, flatulence, vomiting.

From the liver and biliary tract: rarely – liver dysfunction.

Skin and subcutaneous tissue disorders: rarely – allergic dermatitis, sweating, pruritus, urticaria, skin rash.

From the musculoskeletal system: infrequently – muscle weakness, myalgia, pain in the limbs; rarely – discomfort in the limbs; very rarely – osteopenia.

From the kidneys and urinary tract: rarely – enuresis, proteinuria.

General disorders and disorders at the injection site: often – redness of the injection site; infrequently – asthenia (weakness), malaise, fatigue; rarely – a feeling of intoxication, a feeling of heat, irritability, thirst; very rarely – a feeling of discomfort in the chest.

Laboratory and instrumental data: rarely – a decrease in blood pressure, an increase in the concentration of bilirubin, impaired liver function tests, a decrease in the number of platelets, an increase in the number of leukocytes; very rarely – an increase in creatinine levels.

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ® , contains all the information you need to know about the drug, including the indications, route of administration, side effects, and when you should contact your healthcare provider.

Trade names: USA

Condylox

Trade names: Canada

Condyline [DSC]

What is this drug used for?

  • Used for the treatment of genital warts.
  • It is used for the treatment of genital warts in the anus.

What do I need to tell my doctor BEFORE taking this drug?

  • In case of an individual allergic reaction to podofilox or any other component of this drug.
  • If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.
  • if you are breast-feeding or planning to breast-feed.

Combination of this drug with certain medicines and medical conditions may be adverse.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural products and vitamins) and your health problems. You need to make sure that this drug is safe for your medical conditions and in combination with other drugs you are already taking.Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

  • Tell all healthcare providers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
  • Avoid any sexual contact if this medicinal product is applied to the genital skin or to the skin around the anus.
  • Do not use this drug for longer than the period prescribed by your doctor.
  • If symptoms do not improve and get worse after taking the drug for 4 weeks, consult your doctor.
  • During treatment, skin reactions may occur at the site of application of the drug. These reactions may include burning or tingling, itching, pain, or redness. See your doctor if you have a very bad skin reaction that bothers you or does not go away.
  • Tell your doctor if you are pregnant or planning to become pregnant. The benefits and risks of taking this drug during pregnancy will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can cause serious and sometimes deadly side effects. Call your doctor or get medical help right away if you have any of the following signs or symptoms, which may be associated with serious side effects:

  • Signs of an allergic reaction such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
  • Bleeding at the site of drug administration.
  • Swelling at the site of drug administration.

What are some other side effects of this drug?

Any medicine can have side effects. However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

  • Headache.

This list of potential side effects is not comprehensive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you. Follow all instructions strictly.

All forms of issue:

  • Follow your doctor’s instructions for taking this drug. Do not exceed the prescribed dose.
  • Do not take this medication by mouth. For skin application only.Avoid contact with mouth, nose and eyes (possible burns).
  • In case of contact with eyes, rinse immediately with cool water and seek medical attention.
  • Wash hands before and after use.
  • Apply a thin layer to the affected skin.
  • Apply this drug according to the doctor’s instructions or label directions.
  • Apply only to warts and follow your doctor’s directions.
  • Avoid contact with unaffected skin.
  • Avoid contact with untreated leather until treated leather is dry.

Gel:

  • This preparation is flammable. Do not use near open flames or while smoking.

What should I do if a dose of a drug is missed?

  • Take the missed dose as soon as you can.
  • If it is time for your next dose, do not take the missed dose and then return to your normal drug schedule.
  • Do not use 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

All forms of issue:

  • Store at room temperature. Do not freeze.
  • The lid must be tightly closed.
  • Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
  • Dispose of unused or expired drugs.Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

Gel:

  • Keep away from heat or open flame.

Solution:

  • Protect from heat.

General information on medicinal products

  • If your health does not improve or even worsens, see your doctor.
  • Do not give your medicine to anyone or take other people’s medicines.
  • Some medicines may come with other patient information sheets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
  • Some medicines may come with other patient information sheets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
  • If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Use of information by consumer and limitation of liability

This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are suitable for a particular patient.This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient. Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional.Check with your doctor for complete information on the possible risks and benefits of taking this drug. Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Copyright

© UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

90,000 Human papillomavirus, treatment and prevention

To date, there is no specific treatment for human papillomavirus, but it is possible to get rid of genital warts.In addition, you can vaccinate with Gardasil against the four most common HPV types.

For women over 26 years old, the best protection against HPV will be knowledge about this disease, which will minimize the risk of infection. Using condoms, reducing the number of sexual contacts, regular Pap tests are actions that greatly reduce the risk of illness.

Most people with HPV do not need treatment because the immune system gets rid of the virus itself.Only a small number of women develop neoplasms requiring treatment, ranging from warts to cervical cancer.

Generally, genital warts are removed because people don’t like the way they look or because of symptoms, not because treatment prevents more serious illness or transmission of infection to others.

In fact, even after treatment, at least every fourth person will relapse after 3 months.

According to studies, small warts that appeared recently (less than a year ago) respond better to treatment than large ones that appeared long ago.

Experts in the treatment of genital warts believe that there is no perfect treatment for all women. They recommend actively participating in treatment discussions with their doctor. It is very important that the patient is aware of the various options for their treatment.

There is no ideal treatment for asymptomatic genital warts caused by HPV infection (that is, warts that are invisible to the naked eye, diagnosed by colposcopy, biopsy, acetic acid, or laboratory Pap tests) because there is no single way to diagnose asymptomatic genital warts caused by infection.

Treatment previously prescribed by doctors often did more harm than good. Traditional treatments are cryotherapy, when the warts are frozen with liquid nitrogen, and electrocautery, when the warts are electrocuted.

Today, there are many treatments that you or your doctor can apply.

The Centers for Disease Control (USA) has developed the following guidelines:

Self-administered treatment:

    • Podofilox (Condylox).This 0.5 or 0.15 percent solution or gel is relatively inexpensive, safe and easy to use. It is applied directly to the wart daily for three weeks, or twice a day for three days, with a break of four days for three or four weeks. Studies have shown that for warts on the penis, a higher concentration of the drug is needed, and for warts on the female genital organs and in the anus, a lower concentration is needed. It is known that podofilox removes warts in 29 to 90 percent of patients within four to six weeks of using the drug.But after treatment, warts may appear again
  • Imiquimod (Aldara). This 5% cream is used to treat external genital warts as well as perianal warts. The drug is safe, effective and easy to use. To remove warts, the cream stimulates the immune system. It is used three times a week at bedtime for 16 weeks. Warts may reappear after treatment.

Patients tolerate these drugs differently.For example, for you, podofilox may be more effective, and for some, imiquimod. Talk to your doctor about which one is best for you.

Side effects of both drugs may include soreness, irritation, and burning in the area of ​​the skin where the drug was applied. None of these are recommended for use during pregnancy.

Medical treatment:

    • Cryodestruction (freezing of a wart with liquid nitrogen).This is a relatively cheap way. Usually it is not anesthetized and you may feel a little discomfort. Multiple treatments per week for six weeks can be performed to remove all warts
    • Radio wave and laser destruction (using intense radiation to remove a wart) allows you to get rid of warts in one step. However, treatment can be more expensive and the doctor must be qualified.Local or general anesthesia can be given. If the laser correction procedure is not carried out correctly, burns and scars may remain
    • Podophyllin resin 10 – 25 percent. This solution is applied once a week, usually for four weeks. To avoid irritation, it must be washed off 12 hours after application. This treatment has more side effects than the less toxic over-the-counter podofilox.There is no clear confidence that it can be used during pregnancy
    • Trichloroacetic acid (TCA) or dichloroacetic acid (DCU) 10 – 90 percent. These two preparations are applied to the surface of the wart once a week for four weeks. They are stronger forms of over-the-counter acids used to treat external warts. Most doctors prefer to use anesthesia because the procedure can be painful
  • Interferon, a natural human protein known for its antiviral and immunostimulating properties, is injected directly into the wart.The standard dose is one million IU per day for 12 weeks. At this dose, side effects are usually mild. Interferon will be ineffective in people with suppressed immune systems.

Since HPV is a virus, it depends on the immune system whether the warts will return or not. HPV spreads deep into tissues and can remain there indefinitely. Most relapses can occur within the first three months after treatment.

A balanced diet, regular exercise, the use of only certified drugs, and abstinence from smoking and alcohol will help maintain a good immune system.

Prevention of human papillomavirus

At least 75 percent of sexually active adults by the age of 50 have some form of HPV infection that causes genital warts.

HPV vaccination with “Gardasil” is desirable for girls 9 years of age and recommended for girls 11 and 12 years old. In addition, vaccination can be carried out between the ages of 13 and 26 (if it has not been done before).

Clinical trials have shown that the vaccine is safe and prevents 100 percent of HPV 16 and 18, which cause 70 percent of cervical cancers. Gardasil prevents 99 percent of the development of HPV 6 and 11, which cause 90 percent of genital warts.

US Department of Health recommends the use of this drug to prevent vaginal dysplasia, vulvar and cervical dysplasia in women, which cause HPV 16 and 18, and to prevent genital warts, which cause HPV 6 and 11.

Vaccination with Gardasil is carried out in three stages every six months. However, you must remember that Gardasil prevents the emergence of only the four more common types of HPV, but does not protect against all HPVs, therefore, it is necessary to regularly conduct Pap tests and HPV tests.

Vaccination will not work against rare types of the virus if the woman is already infected with this type of HPV. Therefore, the best option to protect against the virus would be to vaccinate before a woman becomes sexually active and vulnerable to the virus.

The CDC recommends vaccinating all women between the ages of 9 and 26 to prevent contracting the four HPV strains targeted by the vaccine.

Even with vaccinations, screening remains an effective way to prevent cervical cancer. The examination includes a PAP, a test that detects abnormalities at the cellular level caused by the human papillomavirus, as well as testing women 30 years of age and older by PCR, a diagnosis for HPV that can detect an existing virus.

To reduce possible contact with the virus transmitted through skin contact, doctors recommend that women follow one or more of the following guidelines:

  • Use condoms with new or casual sex partners. Latex condoms, when used correctly and appropriately throughout intercourse, can protect against HPV by covering an area of ​​infected skin. However, please note that while using a condom reduces the risk of HPV infection, it does not provide 100% protection as the infection can be found on skin cells throughout the genital area
  • Please note that sperm-destroying foams, creams or gels do not protect against sexually transmitted diseases, including HPV.The US Department of Health recommends against the use of vaginal contraceptives containing nonoxynol-9, as it causes increased irritation of the vagina, which may increase the risk of infection 90 090
  • For oral sex, use a rubber dam, plastic wrap, or smooth, unlubricated condom. These materials create a waterproof barrier between the mouth and the vagina or anus during oral sex. Do not brush or floss your teeth before oral sex, as they can cut your skin and increase your risk of contracting the virus
  • Be wary of sharing sex toys.HPV can be transmitted through them if they are poorly washed after your partner.

More detailed information about the human papillomavirus can be obtained from the gynecologists of the Zdorovye 365 clinic in Yekaterinburg.

Related topics:

Removal of papillomas

STD

Inflammatory diseases

Bacterial vaginosis

Menstrual pain

Ovulatory syndrome

Pain in the lower abdomen

Signs of pregnancy

Colposcopy

Miscarriage

Ectopic pregnancy

Premature birth

Hysterosalpingography

Hysteroscopy

Laparoscopy

Gynecological operations

Removal of the uterus

Uterine myoma

Endometriosis

Ovarian cyst

Adenomyosis

Ultrasound of the small pelvis

Ultrasound of mammary glands

Mastopathy

Menopause

90,000 Podofilox Topical: uses, side effects, interactions, pictures, warnings and dosing –

Benefits

Benefits

Podofilox solution is used to treat external genital warts.This stops the growth of the wart and the wart eventually falls off. Podofilox belongs to a group of drugs called antimitotics.

How to use Podofilox Solution, not

Read the Patient Information Leaflet available from your pharmacist before you start using Podofilox Solution and each time you receive a supplement. If you have any questions, ask your doctor or pharmacist.

This medication is for use on the skin only.Only use this medication on genital warts that your doctor has identified for you. Do not use this medication on warts around the anus or on mucous membranes (such as in the urethra, rectum, and vagina), inside your body, or on any other skin growth.

Use this medication usually twice a day (once in the morning and once in the evening, every 12 hours), for 3 consecutive days, and then no treatment for the next 4 days.If the warts persist, you can repeat this 7-day cycle for up to 4 consecutive weeks of treatment. Follow your doctor’s instructions exactly.

First wash the area to be treated with soap and water and dry thoroughly. Use the applicator that comes with this product, soak it in the solution just enough to wet it, but not so much that the solution drips from the tip. Use this medication only on warts that your doctor has prescribed for you to treat. Do not apply it to the area around the warts.It can help to use a hand mirror.

For warts in folds of skin, open folds of skin and apply medication. Let the medicine dry before allowing the skin folds around the warts to return to their normal position.

Use the applicator only once. Do not immerse it in the solution again. Throw it away in a safe place after use. Wash your hands with soap and water after each use.

Do not cover the treated area with bandages or other waterproof dressings.Covering the area with cotton gauze or cotton underwear for the genitals is allowed.

Use this medication regularly to get the most out of it. To help you remember, use a calendar to mark the days on which you will use the medicine each week.

Avoid getting this medication in the eyes / nose / mouth, on healthy skin, or in other areas as directed above. If the medicine comes into contact with healthy skin, wipe it off immediately, wash the area thoroughly with soap and water, and wash off.If the medicine gets into your eyes, nose, or mouth, flush the area with plenty of water for 15 minutes and see a doctor.

Do not apply large amounts of this medication or apply over a large area. Ask your doctor or pharmacist for details. Do not use it more often or for longer than prescribed. Your condition will not improve any faster and your risk of side effects will increase.

Tell your doctor if your condition persists after 4 weeks of treatment, or if it gets worse, or if a lump develops during treatment.Genital warts often come back after treatment.

Related links

In what conditions is Podofilox Solution, without treatment?

Side effects

Side effects

Redness, itching, burning and pain may occur in the treated area. If any of these effects persist or worsen, or if you have bleeding, severe swelling, or severe pain, wash the medicine off with soap and water. Stop using this medication and tell your doctor or pharmacist immediately

Remember that your doctor prescribed this medication for you because he or she thought the benefit to you was greater than the risk of side effects.Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, see your doctor immediately if you notice any symptoms of a serious allergic reaction, including: rash, itching / swelling (especially of the face / tongue / throat), severe dizziness, trouble breathing.

This is not a complete listing of potential side effects. If you notice other effects not listed above, ask your doctor or pharmacist.

In the USA –

Ask your doctor about side effects. You can report side effects to the FDA by calling 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You can report side effects to Health Canada at 1-866-234-2345.

Related links

List Podofilox Solution, side effects by likelihood and severity.

Precautions

Precautions

Before using podofilox, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients that may cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially about: damaged / irritated / inflamed skin around the treated area, recent surgery on the treated area.

This medicine is not a medicine for genital warts. These warts are caused by a virus called human papillomavirus (HPV). Podofilox does not kill the virus. It only helps to remove the warts, but new warts may appear, or old warts may come back during and after treatment.

Do not have sex on the days you were using this medicine.

Genital warts are spread by sexual intercourse. Condoms (such as latex or polyurethane) can help prevent genital warts from spreading to your partner.Check with your doctor or pharmacist for more details.

This medication should not be used during pregnancy. It could harm the unborn baby. Talk to your doctor about using reliable forms of birth control. If you become pregnant or think you might become pregnant, tell your doctor right away.

It is unknown if this drug passes into breast milk. Talk to your doctor before breastfeeding.

Related links

What should I know regarding pregnancy, breastfeeding, and administration of Podofilox Solution, not for children or the elderly?

interactions

interactions

The effect of some medicines may change if you take other medicines or herbal products at the same time. Doing so can increase your risk of serious side effects, or it can cause your medications to not work properly. These drug interactions are possible, but not always the case.Your doctor or pharmacist can often prevent or control interactions by changing the way you use the drugs or by carefully monitoring them.

To help your doctor and pharmacist provide you with the best possible care, be sure to tell your doctor and pharmacist about all products you use (including prescription, over-the-counter, and herbal products) before starting treatment with this product. When using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor’s permission.

Keep a list of all the products you use. Share this list with your doctor and pharmacist to reduce your risk of serious medication problems.

overdose

overdose

This product may be harmful if swallowed. If too much of this medication is applied to your skin, wash it off with plenty of soap and water. If someone has overdosed and has severe symptoms such as fainting or breathing problems, call 911. Otherwise, contact a poison control center immediately.US residents can call their local poison control center at 1-800-222-1222. Residents of Canada can call the provincial poison control center. Overdose symptoms may include: nausea, vomiting, diarrhea, fever, coma, breathing problems, convulsions.

Notes

Do not share this medicine with others.

Keep all medical appointments.

Missed dose

If you miss a dose, use it as soon as you remember. If it is close to your next dose, skip the missed dose and resume your normal dosing regimen.Don’t double your dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat and open flames. Do not freeze. Keep container tightly closed. Keep all medicines out of the reach of children and pets.

Do not flush medicines down the toilet or pour them down the drain unless directed to do so. Correctly discard this product when it has expired or is no longer needed.Consult your pharmacist or local waste disposal company for more information on how to safely dispose of your product. The latest information was revised in July 2016. Copyright (c) 2016 First Databank, Inc.

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