Prescription metoprolol. Metoprolol Interactions: A Comprehensive Guide to Drug, Disease, and Food Interactions
What are the major drug interactions with metoprolol. How many disease interactions does metoprolol have. What are the alcohol and food interactions with metoprolol. How is metoprolol classified in terms of drug interactions.
Overview of Metoprolol Interactions
Metoprolol, a widely prescribed beta-blocker, is known to have numerous interactions with other medications, diseases, and even food and alcohol. Understanding these interactions is crucial for both healthcare providers and patients to ensure safe and effective use of the medication.
According to the drug database, metoprolol has:
- 503 drug interactions
- 19 disease interactions
- 4 alcohol/food interactions
These interactions are further classified based on their severity:
- 26 major interactions
- 440 moderate interactions
- 37 minor interactions
Major Drug Interactions with Metoprolol
Major drug interactions are considered highly clinically significant and should be avoided due to the potential risks outweighing the benefits. Some of the medications that have major interactions with metoprolol include:
- Fluticasone/salmeterol (Advair Diskus)
- Warfarin (Coumadin)
- Apixaban (Eliquis)
- Rivaroxaban (Xarelto)
Healthcare providers should carefully consider these interactions when prescribing metoprolol or any of the above medications.
Moderate and Minor Drug Interactions
While moderate and minor interactions may not be as severe as major interactions, they still require attention and potential adjustments in treatment. Some common medications with moderate or minor interactions include:
- Aspirin
- Diphenhydramine (Benadryl)
- Rosuvastatin (Crestor)
- Duloxetine (Cymbalta)
- Escitalopram (Lexapro)
- Atorvastatin (Lipitor)
- Sertraline (Zoloft)
Patients taking metoprolol should inform their healthcare provider about all medications they are taking, including over-the-counter drugs and supplements.
Disease Interactions with Metoprolol
Metoprolol has 19 known disease interactions. These conditions may affect how the medication works or increase the risk of side effects. Some of the key disease interactions include:
- Bradyarrhythmia/AV block
- Cardiogenic shock/hypotension
- Congestive heart failure (CHF)
- Diabetes
- Liver disease
- Asthma/COPD
- Hyperthyroidism
- Peripheral vascular disease (PVD)
Patients with these conditions should be closely monitored when taking metoprolol, and dosage adjustments may be necessary.
Alcohol and Food Interactions
While the specific details of the 4 alcohol/food interactions are not provided in the given information, it’s important to note that such interactions can affect the efficacy and safety of metoprolol. Patients should discuss any dietary concerns or alcohol consumption habits with their healthcare provider.
Potential Effects of Alcohol
Alcohol consumption while taking metoprolol may lead to increased side effects such as dizziness, lightheadedness, and fainting. It’s generally advised to limit or avoid alcohol while on this medication.
Food Considerations
Certain foods may interact with metoprolol, potentially affecting its absorption or metabolism. Patients should follow their healthcare provider’s advice regarding any dietary restrictions or recommendations.
Understanding Drug Interaction Classifications
Drug interactions are classified into different categories based on their clinical significance and potential risks. For metoprolol, these classifications are:
- Major: Highly clinically significant. Combinations should be avoided as the risk outweighs the benefit.
- Moderate: Moderately clinically significant. These combinations should usually be avoided or used only under special circumstances.
- Minor: Minimally clinically significant. The risk should be minimized by considering alternative drugs, taking steps to circumvent the interaction risk, or implementing a monitoring plan.
- Unknown: No interaction information is available.
These classifications serve as guidelines to help healthcare providers make informed decisions about medication management.
Importance of Medication Reconciliation
Given the extensive list of potential interactions, medication reconciliation is crucial for patients taking metoprolol. This process involves:
- Reviewing all current medications, including over-the-counter drugs and supplements
- Identifying potential interactions
- Making necessary adjustments to the medication regimen
- Educating patients about potential risks and warning signs
Healthcare providers should perform medication reconciliation regularly, especially when changes are made to a patient’s treatment plan.
Patient Education and Monitoring
Educating patients about potential interactions and the importance of adhering to their prescribed regimen is essential for safe and effective use of metoprolol. Key points to emphasize include:
- The need to inform all healthcare providers about their metoprolol use
- The importance of not starting or stopping any medications without consulting their doctor
- Being aware of potential side effects and when to seek medical attention
- Understanding the impact of alcohol and certain foods on their medication
Regular monitoring of patients taking metoprolol is crucial to ensure the medication’s effectiveness and to detect any adverse effects early.
Monitoring Parameters
Healthcare providers should regularly assess:
- Blood pressure and heart rate
- Liver and kidney function
- Blood glucose levels in diabetic patients
- Signs of worsening heart failure in patients with CHF
Alternative Medications and Treatment Options
In cases where metoprolol interactions pose significant risks, healthcare providers may consider alternative medications or treatment options. Some alternatives might include:
- Other beta-blockers with different pharmacokinetic profiles
- ACE inhibitors or angiotensin receptor blockers for certain cardiovascular conditions
- Calcium channel blockers for hypertension management
The choice of alternative treatments should be based on the individual patient’s medical history, current conditions, and overall health status.
Comparing Beta-Blockers
When considering alternatives to metoprolol, healthcare providers may compare different beta-blockers based on their:
- Selectivity (cardioselective vs. non-selective)
- Half-life and duration of action
- Lipid solubility
- Metabolism and elimination pathways
These factors can influence the potential for interactions and side effects in different patient populations.
Metoprolol Interactions Checker – Drugs.com
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There are 503 drugs known to interact with
metoprolol, along with
19 disease interactions, and 4 alcohol/food interactions.
Of the total drug interactions,
26 are major, 440 are moderate, and 37 are minor.
Does metoprolol interact with my other drugs?
Enter other medications to view a detailed report.
- View all 503 medications that may interact with metoprolol
- View metoprolol alcohol/food interactions (4)
- View metoprolol disease interactions (19)
Most frequently checked interactions
View interaction reports for metoprolol and the medicines listed below.
- Major
- Moderate
- Minor
- Unknown
- Advair Diskus (fluticasone / salmeterol)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Coumadin (warfarin)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lantus (insulin glargine)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Plavix (clopidogrel)
- Protonix (pantoprazole)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Metoprolol alcohol/food interactions
There are 4 alcohol/food interactions with metoprolol.
Metoprolol disease interactions
There are 19 disease interactions with metoprolol which include:
- bradyarrhythmia/AV block
- cardiogenic shock/hypotension
- CHF
- diabetes
- hemodialysis
- hypersensitivity
- ischemic heart disease
- PVD
- liver disease
- cerebrovascular insufficiency
- glaucoma
- hyperlipidemia
- hyperthyroidism
- hyperthyroidism PKs
- myasthenia gravis
- pheochromocytoma
- psoriasis
- tachycardia
- asthma/COPD
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Drug Interaction Classification
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
|---|---|
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Metoprolol Pill Images – What does metoprolol look like?
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What does Metoprolol tartrate look like?
Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi ingredient medications may also be listed when applicable.
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What helps, analogs, prescription, dosage, mechanism of action
THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.
Podoinitsyna Alena Andreevna,
Diploma in Pharmaceutical Education: 105924 3510722 reg. number 31917
All authors
Content of the article
- Metoprolol: mechanism of action
- Metoprolol: from what
- Metoprolol: prescription
- Metoprolol: dosage
- Metoprolol: analogues
- Metoprolol or Egilok: which is better
- Anaprilin or Metoprolol: which is better
- Summary
- Ask an expert on the topic of the article
Hypertension is a chronic disease, the main manifestation of which is an increase in blood pressure.
High blood pressure is responsible for 10 million deaths and 200 million disabilities worldwide. Symptoms of hypertension are either absent or nonspecific: headache, dizziness, palpitations.
Hypertension can and should be treated and controlled with medicines. We asked the pharmacist Alena Podoinitsyna to tell us about the drug Metoprolol: what it is prescribed for, in what dosages it is produced and what is the mechanism of action of the drug. They gave several examples of analogues of Metoprolol, and also compared it with Egilok and Anaprilin.
All products Metoprolol
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Metoprolol: mechanism of action
Metoprolol is a medicine that is taken for high blood pressure. The drug blocks beta-adrenergic receptors. Blockade of beta-adrenergic receptors leads to a decrease in the number of heart contractions, contractility and speed of contraction of the heart muscle, while reducing myocardial oxygen demand.
Metoprolol: from what
We understand what Metoprolol tablets are from.
The drug has antihypertensive, antianginal and antiarrhythmic effects. Metoprolol is a beta-blocker. It helps to reduce pressure at rest, during stress and physical exertion.
Antianginal effect is manifested in a decrease in heart rate and a decrease in the heart’s need for oxygen. The antiarrhythmic effect is expressed in the elimination of tachycardia, a decrease in the excitability of the heart and the conduction of nerve impulses in its tissues.
Metoprolol: indications for use
- high blood pressure
- angina pectoris
- complex therapy after a heart attack
- arrhythmia, tachycardia
- migraine prophylaxis
- hyperthyroidism
Prescription metoprolol
Metoprolol is a prescription drug. When buying it, a pharmacy employee will ask you to provide a prescription from a doctor. The drug is available by prescription, as when used in recommended doses, the patient can harm himself.
Metoprolol has side effects and contraindications. Only a doctor can evaluate the benefit-risk ratio of the drug. Therefore, the decision on the need for his appointment is also made by the doctor.
Metoprolol: contraindications for use
- hypersensitivity to any component of the preparation
- atrioventricular block II and III degree
- heart failure in the stage of decompensation
- patient therapy with nootropics acting on beta-adrenergic receptors
- decrease in heart rate below 60 beats per minute
- cardiogenic shock
- circulatory disorders in the organs, or the threat of gangrene
- low blood pressure
- acute myocardial infarction
- lactose intolerance, glucose-galactose malabsorption
- children under 18 years of age
- severe form of bronchial asthma and chronic obstructive pulmonary disease.
- concomitant use of certain groups of drugs
- lactation
Metoprolol: dosage
Metoprolol contains the active ingredient: metoprolol tartrate, at a dosage of 100 mg per 1 tablet.
But we note that Metoprolol is produced on the basis of 2 active ingredients, or rather, salts. Each of them carries an action peculiar only to it.
- Metoprolol tartrate – the substance is contained in tablets of immediate action, these tablets must be taken several times a day.
- Metoprolol succinate – the substance is contained in tablets with a delayed release, respectively, such tablets are drunk 1 time per day.
Metoprolol: analogues
In order to choose metoprolol analogues and substitutes, a specialist consultation is necessary. Egilok, Serdol, Metocard, Betalok, Betalok ZOK contain metoprolol as an active substance. Metoprolol can be replaced with them without consulting a doctor. We recommend that you consult with a pharmacy employee or a pharmacist in the chat on our service. The specialist will help you choose the right dosage and dosage form.
The need to change to drugs with a different active substance is determined by the doctor.
Metoprolol is part of the combined preparations. For example, Logimax, Implicor, Hypotef. They, in addition to metoprolol, contain other active ingredients. You can not replace them with a simple Metoprolol.
Do you want to understand the analogues of drugs in order to skillfully select drugs for your budget? Our manual from expert pharmacists “Analogues of popular drugs” will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.
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Metoprolol or Egilok: which is better
When choosing the best drug, you should first consult with your doctor. There are practically no differences between Metoprolol and Egilok. Preparations differ by manufacturers:
- Metoprolol is produced in Russia, Slovenia, Israel, Slovakia and Germany
- Egilok is produced only in Hungary.
Other characteristics, such as: mechanism of action, indications for use, contraindications, side effects and other special indications, are the same for both drugs. All characteristics depend on the active substance. In both preparations, it is metoprolol tartrate. Therefore, Egilok is a substitute for Metoprolol.
Anaprilin or Metoprolol: which is better
Both drugs belong to the same group of drugs – beta-blockers. But the active ingredients are different. Anaprilin contains propranolol hydrochloride.
The difference between active substances lies in the mechanism of their action.
- Metoprolol is a non-selective adrenoblocker and acts on beta1-adrenergic receptors
- Anaprilin is selective and acts on beta1- and beta2-adrenergic receptors.
Thus, Anaprilin has more side effects and contraindications than Metoprolol. For example: both drugs should be taken with caution in diabetes mellitus.
Metoprolol is also with caution in: chronic obstructive pulmonary disease and bronchial asthma, and Anaprilin is completely contraindicated.
Preparations and manufacturers differ.
- Anaprilin is produced by Russia and Ukraine
- Metoprolol is produced by Russia and 4 other countries.
Follow your doctor’s advice to select the best drug.
All products Egilok
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Summary
- Metoprolol is an antihypertensive drug that is often prescribed for the treatment of hypertension, coronary heart disease and arrhythmias.
- Metoprolol is a prescription drug and is available only on prescription.
- The active substance of metoprolol is the salt of metoprolol succinate or tartrate.
- Metoprolol lowers blood pressure by reducing the heart’s need for oxygen and reducing the heart rate.
- Metoprolol has 4 analogues with which it can be substituted.
- When comparing Metoprolol with Egilok, differences were found only in manufacturers.
- Anaprilin differs from Metoprolol not only in producing companies, but also in the active substance.
Ask an expert about the topic of the article
Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.
Managing editor
Zotina Natalya Igorevna,
Expert pharmacist
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