What are the major drug interactions with metoprolol. How many disease interactions does metoprolol have. What are the alcohol and food interactions with metoprolol. How to check metoprolol interactions with other medications.

Overview of Metoprolol Interactions

Metoprolol, a widely prescribed beta-blocker, is known to have numerous interactions with other substances. Understanding these interactions is crucial for patient safety and optimal treatment outcomes. This comprehensive guide explores the various interactions associated with metoprolol, including drug-drug interactions, disease interactions, and alcohol/food interactions.

Key Interaction Statistics

• Total drug interactions: 503
• Disease interactions: 19
• Alcohol/food interactions: 4

The drug interactions are further categorized based on their severity:

• Major interactions: 26
• Moderate interactions: 440
• Minor interactions: 37

Significant Drug Interactions with Metoprolol

While metoprolol interacts with numerous medications, some of the most frequently checked interactions include:

• Aspirin (both low strength and regular)
• Warfarin (Coumadin)
• Duloxetine (Cymbalta)
• Escitalopram (Lexapro)
• Atorvastatin (Lipitor)
• Sertraline (Zoloft)

These interactions can range from minor to major in severity. For instance, combining metoprolol with certain antidepressants like duloxetine or escitalopram may increase the risk of side effects or alter the effectiveness of either medication.

How can patients check for metoprolol interactions?

Patients can use online drug interaction checkers or consult with their healthcare provider or pharmacist. It’s crucial to provide a complete list of all medications, including over-the-counter drugs, supplements, and herbal products, to ensure a comprehensive interaction check.

Disease Interactions with Metoprolol

Metoprolol has 19 known disease interactions. These interactions are particularly important as they can affect the safety and efficacy of the medication in patients with certain medical conditions.

Key Disease Interactions

• Bradyarrhythmia/AV block
• Cardiogenic shock/hypotension
• Congestive heart failure (CHF)
• Diabetes
• Liver disease
• Asthma/COPD
• Hyperthyroidism
• Peripheral vascular disease (PVD)

For example, in patients with asthma or COPD, metoprolol may exacerbate bronchospasm, potentially worsening respiratory symptoms. Similarly, in diabetic patients, metoprolol may mask the symptoms of hypoglycemia, making blood sugar management more challenging.

Alcohol and Food Interactions with Metoprolol

Metoprolol has 4 known alcohol/food interactions. While the specifics of these interactions are not detailed in the provided information, it’s important to be aware of potential effects.

Why are alcohol and food interactions important?

Alcohol and certain foods can affect how metoprolol is metabolized in the body, potentially altering its effectiveness or increasing the risk of side effects. For instance, alcohol can enhance the blood pressure-lowering effect of metoprolol, potentially leading to dizziness or fainting.

Understanding Drug Interaction Classifications

Drug interactions are classified based on their clinical significance and the recommended course of action:

• Major: Highly clinically significant. Combinations should be avoided as the risk outweighs the benefit.
• Moderate: Moderately clinically significant. These combinations should usually be avoided or used only under special circumstances.
• Minor: Minimally clinically significant. The risk should be minimized by considering alternative drugs or implementing a monitoring plan.
• Unknown: No interaction information is available.

It’s important to note that these classifications serve as guidelines. The relevance of a particular interaction can vary between individuals, highlighting the need for personalized medical advice.

Identifying Metoprolol: Pill Images and Characteristics

Metoprolol tartrate is available in various strengths and formulations. Identifying the correct medication is crucial for patient safety and proper dosing.

Common Metoprolol Tartrate Formulations

• 50 mg: Pink, round tablet with imprint “M 32”
• 100 mg: Blue, round tablet with imprint “M 47”
• 100 mg: White, round tablet with imprint “GG 415”
• 100 mg: White, oval tablet with imprint “167”

These descriptions can help patients and healthcare providers verify the medication. However, it’s important to note that appearances may vary depending on the manufacturer.

Managing Metoprolol Interactions: Best Practices

Given the numerous interactions associated with metoprolol, careful management is essential for safe and effective treatment.

How can patients minimize the risk of metoprolol interactions?

1. Maintain an up-to-date list of all medications, including over-the-counter drugs and supplements.
2. Inform all healthcare providers about metoprolol use before starting any new medications.
3. Discuss any existing medical conditions with the prescribing physician.
4. Be aware of potential alcohol and food interactions, and follow dietary recommendations.
5. Regularly review medications with a healthcare provider or pharmacist to check for potential interactions.

By following these practices, patients can help ensure the safe and effective use of metoprolol while minimizing the risk of adverse interactions.

Special Considerations for Metoprolol Use

While metoprolol is an effective medication for various cardiovascular conditions, certain patient groups require special attention due to potential interactions or increased risks.

Metoprolol in Pregnancy and Breastfeeding

The use of metoprolol during pregnancy and breastfeeding requires careful consideration. While not explicitly detailed in the provided information, it’s known that beta-blockers can cross the placenta and may affect fetal development. Similarly, metoprolol can pass into breast milk, potentially affecting nursing infants.

What precautions should be taken for elderly patients on metoprolol?

Elderly patients may be more sensitive to the effects of metoprolol and may require dose adjustments. Factors to consider include:

• Increased risk of bradycardia and hypotension
• Potential for drug interactions due to polypharmacy
• Changes in drug metabolism and elimination with age
• Increased susceptibility to side effects

Healthcare providers should closely monitor elderly patients on metoprolol and adjust dosages as needed to ensure optimal therapeutic benefit while minimizing risks.

Metoprolol in Specific Medical Conditions

Metoprolol’s use in certain medical conditions requires special attention due to potential interactions or altered effectiveness.

Metoprolol in Cardiovascular Conditions

While metoprolol is primarily used to treat cardiovascular conditions, its use in certain cardiac situations requires caution:

• Congestive Heart Failure (CHF): Metoprolol may worsen heart failure symptoms initially, requiring careful titration and monitoring.
• Bradyarrhythmias: Metoprolol can exacerbate slow heart rhythms, necessitating close cardiac monitoring.
• Peripheral Vascular Disease (PVD): Beta-blockers like metoprolol may worsen symptoms of PVD in some patients.

How does metoprolol affect patients with diabetes?

Metoprolol can mask some symptoms of hypoglycemia in diabetic patients, such as increased heart rate. This can make it more difficult for patients to recognize when their blood sugar is low. Additionally, metoprolol may alter insulin sensitivity and glucose metabolism. Diabetic patients on metoprolol should:

• Monitor blood glucose levels more frequently
• Be aware of other hypoglycemia symptoms like sweating and dizziness
• Work closely with their healthcare provider to adjust diabetes management as needed

These considerations underscore the importance of individualized treatment plans and regular monitoring for patients with complex medical histories.

Metoprolol Interactions Checker – Drugs.com

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There are 503 drugs known to interact with
metoprolol, along with
19 disease interactions, and 4 alcohol/food interactions.

Of the total drug interactions,
26 are major, 440 are moderate, and 37 are minor.

Does metoprolol interact with my other drugs?

Enter other medications to view a detailed report.

• View all 503 medications that may interact with metoprolol
• View metoprolol alcohol/food interactions (4)
• View metoprolol disease interactions (19)

Most frequently checked interactions

View interaction reports for metoprolol and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Advair Diskus (fluticasone / salmeterol)
• Aspir 81 (aspirin)
• Aspirin Low Strength (aspirin)
• Benadryl (diphenhydramine)
• CoQ10 (ubiquinone)
• Coumadin (warfarin)
• Crestor (rosuvastatin)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Lantus (insulin glargine)
• Lasix (furosemide)
• Lexapro (escitalopram)
• Lipitor (atorvastatin)
• Lyrica (pregabalin)
• Nexium (esomeprazole)
• Norco (acetaminophen / hydrocodone)
• Plavix (clopidogrel)
• Protonix (pantoprazole)
• Singulair (montelukast)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Xarelto (rivaroxaban)
• Zoloft (sertraline)
• Zyrtec (cetirizine)

Metoprolol alcohol/food interactions

There are 4 alcohol/food interactions with metoprolol.

Metoprolol disease interactions

There are 19 disease interactions with metoprolol which include:

• bradyarrhythmia/AV block
• cardiogenic shock/hypotension
• CHF
• diabetes
• hemodialysis
• hypersensitivity
• ischemic heart disease
• PVD
• liver disease
• cerebrovascular insufficiency
• glaucoma
• hyperlipidemia
• hyperthyroidism
• hyperthyroidism PKs
• myasthenia gravis
• pheochromocytoma
• psoriasis
• tachycardia
• asthma/COPD

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More about metoprolol

• metoprolol consumer information
• Compare alternatives
• Reviews (628)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: cardioselective beta blockers
• Breastfeeding
• En español

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Metoprolol Pill Images – What does metoprolol look like?

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What does Metoprolol tartrate look like?

Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi ingredient medications may also be listed when applicable.
Return to Pill Identifier…

Results for “Metoprolol tartrate” (

1 – 18 of 102)

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Metoprolol Tartrate

Strength

50 mg

Imprint

M 32

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Pink

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Round

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Metoprolol Tartrate

Strength

100 mg

Imprint

M 47

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Blue

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Round

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1 / 2

Metoprolol Tartrate

Strength

100 mg

Imprint

GG 415

Color

White

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Round

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1 / 4

Metoprolol Tartrate

Strength

100 mg

Imprint

167

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White

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Metoprolol Tartrate

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50 mg

Imprint

GG 414

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White

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100 mg

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GG 415

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50 mg

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MP 184

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100 mg

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MP 185

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Metoprolol Tartrate

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50 mg

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93 733

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100 mg

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93 734

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Metoprolol Tartrate

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50 N 727

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50 mg

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WATSON 462

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Metoprolol Tartrate

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100 mg

Imprint

WATSON 463

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1 / 5

Metoprolol Tartrate

Strength

25 mg

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M 18

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White

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Metoprolol Tartrate

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50 mg

Imprint

554 R

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1 / 2

Metoprolol Tartrate

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50 mg

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166

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White

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25 mg

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1

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Metoprolol Tartrate

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100 mg

Imprint

100 N 734

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White

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Oval

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Further information

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Medical Disclaimer

What helps, analogs, prescription, dosage, mechanism of action

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.

Podoinitsyna Alena Andreevna,

Diploma in Pharmaceutical Education: 105924 3510722 reg. number 31917

All authors

Content of the article

• Metoprolol: mechanism of action
• Metoprolol: from what
• Metoprolol: prescription
• Metoprolol: dosage
• Metoprolol: analogues
• Metoprolol or Egilok: which is better
• Anaprilin or Metoprolol: which is better
• Summary
• Ask an expert on the topic of the article

Hypertension is a chronic disease, the main manifestation of which is an increase in blood pressure. High blood pressure is responsible for 10 million deaths and 200 million disabilities worldwide. Symptoms of hypertension are either absent or nonspecific: headache, dizziness, palpitations.

Hypertension can and should be treated and controlled with medicines. We asked the pharmacist Alena Podoinitsyna to tell us about the drug Metoprolol: what it is prescribed for, in what dosages it is produced and what is the mechanism of action of the drug. They gave several examples of analogues of Metoprolol, and also compared it with Egilok and Anaprilin.

All products Metoprolol

20 reviews

Metoprolol: mechanism of action

Metoprolol is a medicine that is taken for high blood pressure. The drug blocks beta-adrenergic receptors. Blockade of beta-adrenergic receptors leads to a decrease in the number of heart contractions, contractility and speed of contraction of the heart muscle, while reducing myocardial oxygen demand.

Metoprolol: from what

We understand what Metoprolol tablets are from. The drug has antihypertensive, antianginal and antiarrhythmic effects. Metoprolol is a beta-blocker. It helps to reduce pressure at rest, during stress and physical exertion.

Antianginal effect is manifested in a decrease in heart rate and a decrease in the heart’s need for oxygen. The antiarrhythmic effect is expressed in the elimination of tachycardia, a decrease in the excitability of the heart and the conduction of nerve impulses in its tissues.

Metoprolol: indications for use

• high blood pressure
• angina pectoris
• complex therapy after a heart attack
• arrhythmia, tachycardia
• migraine prophylaxis
• hyperthyroidism

Prescription metoprolol

Metoprolol is a prescription drug. When buying it, a pharmacy employee will ask you to provide a prescription from a doctor. The drug is available by prescription, as when used in recommended doses, the patient can harm himself.

Metoprolol has side effects and contraindications. Only a doctor can evaluate the benefit-risk ratio of the drug. Therefore, the decision on the need for his appointment is also made by the doctor.

Metoprolol: contraindications for use

• hypersensitivity to any component of the preparation
• atrioventricular block II and III degree
• heart failure in the stage of decompensation
• patient therapy with nootropics acting on beta-adrenergic receptors
• decrease in heart rate below 60 beats per minute
• cardiogenic shock
• circulatory disorders in the organs, or the threat of gangrene
• low blood pressure
• acute myocardial infarction
• lactose intolerance, glucose-galactose malabsorption
• children under 18 years of age
• severe form of bronchial asthma and chronic obstructive pulmonary disease.
• concomitant use of certain groups of drugs
• lactation

Metoprolol: dosage

Metoprolol contains the active ingredient: metoprolol tartrate, at a dosage of 100 mg per 1 tablet. But we note that Metoprolol is produced on the basis of 2 active ingredients, or rather, salts. Each of them carries an action peculiar only to it.

• Metoprolol tartrate – the substance is contained in tablets of immediate action, these tablets must be taken several times a day.
• Metoprolol succinate – the substance is contained in tablets with a delayed release, respectively, such tablets are drunk 1 time per day.

Metoprolol: analogues

In order to choose metoprolol analogues and substitutes, a specialist consultation is necessary. Egilok, Serdol, Metocard, Betalok, Betalok ZOK contain metoprolol as an active substance. Metoprolol can be replaced with them without consulting a doctor. We recommend that you consult with a pharmacy employee or a pharmacist in the chat on our service. The specialist will help you choose the right dosage and dosage form.

The need to change to drugs with a different active substance is determined by the doctor. Metoprolol is part of the combined preparations. For example, Logimax, Implicor, Hypotef. They, in addition to metoprolol, contain other active ingredients. You can not replace them with a simple Metoprolol.

Do you want to understand the analogues of drugs in order to skillfully select drugs for your budget? Our manual from expert pharmacists “Analogues of popular drugs” will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.

Megapharmacy in social networks: VKontakte, Telegram, OK, Viber

Metoprolol or Egilok: which is better

When choosing the best drug, you should first consult with your doctor. There are practically no differences between Metoprolol and Egilok. Preparations differ by manufacturers:

• Metoprolol is produced in Russia, Slovenia, Israel, Slovakia and Germany
• Egilok is produced only in Hungary.

Other characteristics, such as: mechanism of action, indications for use, contraindications, side effects and other special indications, are the same for both drugs. All characteristics depend on the active substance. In both preparations, it is metoprolol tartrate. Therefore, Egilok is a substitute for Metoprolol.

Anaprilin or Metoprolol: which is better

Both drugs belong to the same group of drugs – beta-blockers. But the active ingredients are different. Anaprilin contains propranolol hydrochloride.

The difference between active substances lies in the mechanism of their action.

• Metoprolol is a non-selective adrenoblocker and acts on beta1-adrenergic receptors
• Anaprilin is selective and acts on beta1- and beta2-adrenergic receptors.

Thus, Anaprilin has more side effects and contraindications than Metoprolol. For example: both drugs should be taken with caution in diabetes mellitus. Metoprolol is also with caution in: chronic obstructive pulmonary disease and bronchial asthma, and Anaprilin is completely contraindicated.

Preparations and manufacturers differ.

• Anaprilin is produced by Russia and Ukraine
• Metoprolol is produced by Russia and 4 other countries.

Follow your doctor’s advice to select the best drug.

All products Egilok

20 reviews

All products Anaprilin

21 reviews

Summary

• Metoprolol is an antihypertensive drug that is often prescribed for the treatment of hypertension, coronary heart disease and arrhythmias.
• Metoprolol is a prescription drug and is available only on prescription.
• The active substance of metoprolol is the salt of metoprolol succinate or tartrate.
• Metoprolol lowers blood pressure by reducing the heart’s need for oxygen and reducing the heart rate.
• Metoprolol has 4 analogues with which it can be substituted.
• When comparing Metoprolol with Egilok, differences were found only in manufacturers.
• Anaprilin differs from Metoprolol not only in producing companies, but also in the active substance.

Ask an expert about the topic of the article

Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.

Managing editor

Zotina Natalya Igorevna,

Expert pharmacist

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