What They Are and How to Manage Them

If you have depression, your doctor might suggest Pristiq as a treatment option for you.

Pristiq is a prescription drug that’s used to treat major depressive disorder in adults.

The active ingredient in Pristiq is desvenlafaxine. An active ingredient is what makes a drug work. Pristiq comes as a tablet that you swallow. It’s usually taken long term.

For more information about Pristiq, including details about its uses, see this in-depth article.

Like other drugs, Pristiq can cause mild to serious side effects. Keep reading to learn more.

Some people may experience mild to serious side effects during Pristiq treatment. Examples of Pristiq’s commonly reported side effects include:

• dizziness
• trouble sleeping
• increased sweating
• loss of appetite
• nausea*

* To learn more about this side effect, see the “Side effects explained” section below.

Read on to learn about other potential mild and serious side effects of Pristiq.

Pristiq may cause mild side effects. Examples of mild side effects that have been reported with Pristiq include:

• dizziness
• vomiting
• trouble sleeping
• increased sweating
• drowsiness
• loss of appetite
• anxiety
• dry mouth
• sexual side effects*
• nausea*
• headache*
• constipation*
• mild allergic reaction*

* To learn more about this side effect, see the “Side effects explained” section below.

In most cases, these side effects should be temporary. And some may be easily managed, too. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. And do not stop taking Pristiq unless your doctor recommends it.

Pristiq may cause mild side effects other than the ones listed above. See the Pristiq prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Pristiq, visit MedWatch.

Pristiq can cause serious side effects, though these are usually rare. Serious side effects that have been reported with Pristiq are listed below. Some of these side effects were reported in studies of Pristiq. But others were reported after the drug became available on the market.

• increased blood pressure
• mania and hypomania, which cause elevated mood
• serotonin syndrome, resulting from a buildup of the chemical serotonin
• increased risk of bleeding, which may be life threatening
• angle-closure glaucoma, a serious eye condition
• discontinuation syndrome, which causes withdrawal symptoms
• seizures
• low level of sodium in the blood
• risk of suicidal thoughts and actions*
• severe allergic reaction†‡

* Pristiq has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effects explained” section below.
† To learn more about this side effect, see the “Side effects explained” section below.
‡ An allergic reaction is possible after taking Pristiq. But this side effect wasn’t reported in studies.

If you develop serious side effects while taking Pristiq, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Get answers to some frequently asked questions about Pristiq’s side effects.

Does Pristiq cause weight gain?

It’s possible. In studies of Pristiq, weight gain was not a reported side effect. But after Pristiq was made available on the market, some people who took it reported gaining weight.

It’s important to note that weight changes, including weight gain, can be a symptom of depression.

If you experience weight gain while taking Pristiq, talk with your doctor. They may have tips to help with this side effect.

If I suddenly stop taking Pristiq, will I have withdrawal symptoms?

Yes, it’s possible. Withdrawal symptoms may be a side effect of stopping Pristiq, and they can be mild or serious. Some of the mild symptoms of withdrawal include:

• nausea
• sweating
• dizziness
• headache
• trouble sleeping
• “brain zaps” (feeling an electrical jolt in the head that may travel to other parts of the body)
• irritability, anxiety, or agitation

Some serious symptoms of withdrawal include:

• seizure
• suicidal thoughts
• severe aggression
• increased blood pressure
• blurry vision

These side effects are more likely to happen if you stop taking Pristiq suddenly. If you want to stop taking Pristiq, talk with your doctor first. They’ll likely recommend that you take a smaller dose for a while rather than stopping Pristiq abruptly. It may take several months to stop taking Pristiq completely.

Will my risk of side effects be higher with the 100-mg dose of Pristiq than with lower doses of the drug?

It’s possible. During studies of Pristiq, people took different doses of the drug. The side effects that were reported were the same for each dosage. But more people who took the 100-milligram (mg) dose reported certain side effects than those who took the 50-mg dose. Some of these side effects were:

• dry mouth
• sleepiness
• trouble sleeping
• certain sexual side effects*
• nausea*

* To learn more about this side effect, see the “Side effects explained” section below.

Learn more about some of the side effects Pristiq may cause.

Risk of suicidal thoughts and actions

Pristiq carries a boxed warning about the risk of suicidal thoughts and actions in children, adolescents, and adults ages 24 years and younger. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Antidepressants such as Pristiq may increase the risk of suicidal thoughts and actions in people under 25 years of age. The FDA has not approved the use of Pristiq in people ages 18 years or younger.

Symptoms of suicidal thoughts and actions include:

• sudden changes in mood, behaviors, thoughts, or feelings
• trouble sleeping
• new or worsened irritability or depression
• extreme anger, violence, or aggression
• extreme increase in talking, excitement, and activity, which can result from mania
• panic attack
• impulsive behavior
• thoughts about dying or hurting yourself
• suicide attempts

What might help

Keep track of how you feel while taking Pristiq. If you experience any of the symptoms listed above while taking Pristiq, tell your doctor right away.

Consider letting people close to you know about this Pristiq side effect and its symptoms. They can also help you watch out for these symptoms.

If you’re 18 to 24 years of age, your doctor may monitor you more closely for symptoms of suicidal thoughts and actions during Pristiq treatment.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The Suicide and Crisis Lifeline is available 24 hours per day when you call 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 and then 800-273-8255.

Click here for more links and local resources.

Sexual side effects

Antidepressants such as Pristiq may cause sexual side effects. In studies of the drug, males* reported:

• decreased libido
• problems getting an erection
• delayed ejaculation

In studies of the drug, females* reported:

• not being able to reach orgasm
• decreased libido

* In this article, we use the terms “male” and “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

What might help

Over time, sexual side effects may lessen on their own. Sometimes, switching to a different antidepressant may help. If you experience any sexual side effects while taking Pristiq, tell your doctor. They can suggest ways to help ease sexual side effects.

Nausea

In studies, nausea was a common side effect of Pristiq. By itself, nausea may be considered a mild side effect. But it can be a symptom of withdrawal, which may occur if you stop taking Pristiq suddenly. (For more information, see the “FAQs about Pristiq’s side effects” section above.)

Nausea may also be a symptom of serotonin syndrome. This is a serious condition that can happen when too much serotonin builds up in the body.

Other symptoms of serotonin syndrome include:

• confusion
• agitation
• dizziness
• racing heartbeat or changes in blood pressure
• flushing (temporary warmth, redness, or deepening of skin color) or sweating
• seizure
• muscle twitching or tremors
• seeing or hearing things that aren’t real
• increased body temperature
• severe vomiting or diarrhea
• coma

What might help

If you have nausea with Pristiq, the following tips may help ease this side effect:

• Take your dose with some crackers or toast.
• Try drinks or foods that contain ginger.
• Ask your doctor about medications that can help decrease nausea.

If your nausea is severe or occurs with the symptoms of serotonin syndrome listed above, seek immediate medical care.

Headache

Headache was a common side effect in short-term studies of Pristiq. This side effect was usually mild.

This side effect may also occur if you suddenly stop Pristiq. (For more information, see the “FAQs about Pristiq’s side effects” section above.)

Headaches may be a symptom of a low blood level of sodium. This is a side effect of certain antidepressants such as Pristiq, and it can be a serious problem. Older adults (ages 65 years and older) and people who take diuretics may have a higher risk of this side effect. Symptoms to watch out for include:

• confusion
• problems with concentration or memory
• feeling weak and unsteady
• seeing or hearing things that aren’t real
• seizure
• fainting
• coma

What might help

Mild headaches may lessen a few weeks after starting Pristiq. But if this side effect continues to bother you, talk with your doctor. They may recommend medications to treat your headaches.

If your headaches occur with the other symptoms of a low blood level of sodium listed above, seek immediate medical treatment.

Constipation

Constipation was a common, mild side effect in studies of Pristiq.

What might help

Constipation usually goes away after taking Pristiq for a few weeks. Drinking more water and mild exercise may help with this side effect.

If you experience constipation that becomes severe, talk with your doctor. They may recommend changes in your diet or medications to help relieve this side effect.

Allergic reaction

Like most drugs, Pristiq can cause an allergic reaction in some people. But this side effect wasn’t reported in studies.

Symptoms can be mild to serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, usually in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest treatment options to manage your symptoms. Examples include:

• an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
• a product you apply to your skin, such as hydrocortisone cream

If your doctor confirms you’ve had a mild allergic reaction to Pristiq, they’ll decide if you should continue taking it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Pristiq, they may have you switch to a different treatment.

Keeping track of side effects

During your Pristiq treatment, consider taking notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful when you first start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of the drug you were taking when you had the side effect
• how soon you had the side effect after starting that dose
• what your symptoms were
• how it affected your daily activities
• what other medications you were taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help them learn more about how Pristiq affects you. They can then use this information to adjust your treatment plan if needed.

Pristiq comes with several warnings.

Boxed warning: Risk of suicidal thoughts and actions

Pristiq has a boxed warning for the risk of suicidal thoughts and actions in children, adolescents, and adults ages 24 years and younger. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

To learn more, see the “Side effects explained” section above.

Other warnings

Pristiq may cause drug-condition interactions. This means that Pristiq may not be right for you if you have certain medical conditions. Other factors may also affect whether Pristiq is a good treatment option for you.

Talk with your doctor about your health history before starting Pristiq. The list below includes factors to consider.

High blood pressure. Pristiq can cause your blood pressure to increase.If you have high blood pressure, your doctor may prescribe medication to treat it before you start taking Pristiq. Then they’ll monitor your blood pressure to make sure it’s well-managed. If your blood pressure remains high, your doctor may adjust your dosage of Pristiq or recommend a different antidepressant.

Heart disease. If you have heart disease, Pristiq may make it worse. Pristiq can increase your blood pressure, which may worsen heart disease. If you have a history of heart disease or high blood pressure, tell your doctor before starting Pristiq treatment.

Stroke or ministroke. Pristiq can increase your blood pressure, so it may increase your risk of stroke if you’ve had one before. If you’ve had a stroke or if you’ve had any problems with high blood pressure, let your doctor know. This will help them determine whether it’s safe for you to take Pristiq.

Bleeding problems. Medications like Pristiq may increase your risk of bleeding. If you take medications that increase bleeding, your risk may be greater. Before you take Pristiq, make sure your doctor knows all of the medications you take.

Angle-closure glaucoma. Pristiq may cause dilation of the pupils in the eye. This can cause an episode of glaucoma in certain people. Because of this, doctors will likely not prescribe Pristiq to anyone with this kind of glaucoma. If you have a history of glaucoma or if you take any eye drops for glaucoma, tell your doctor. They’ll discuss with you treatment options that are safe for you to take.

Mania, hypomania, or bipolar disorder. Pristiq may not be the right medication for people who have had mania, hypomania, or bipolar disorder. It also may not be safe for people who have a family history of these mental health conditions. If you have bipolar disorder, Pristiq can increase your risk of a manic episode. Before you start Pristiq treatment, tell your doctor about any mental health conditions you or close family members have had.

Allergic reaction. If you’ve had an allergic reaction to Pristiq or any of its ingredients, your doctor will likely not prescribe Pristiq. Ask them what other medications are better options for you.

Seizures or epilepsy. Pristiq was not studied in people with a history of seizures or epilepsy. If you’ve ever had a seizure or have epilepsy, tell your doctor. They’ll let you know if Pristiq is safe for you to take.

Low sodium level. Pristiq can lower the blood level of sodium, which can become a serious problem. Older adults (ages 65 years and older) or people who take diuretics may have a higher risk of this side effect. If you are an older adult or take a diuretic, or have had problems with a low sodium level in the past, your doctor will let you know whether it’s safe to take Pristiq.

Liver problems. If you have liver problems, your body may have trouble getting rid of Pristiq. Before you start treatment, tell your doctor about any liver problems you have or have had. They may prescribe a lower dosage of Pristiq.

Kidney problems. If you have kidney problems, your body may have trouble getting rid of Pristiq. Before you start treatment, tell your doctor about any kidney problems you have or have had. They may recommend that you take a lower dosage of Pristiq.

High cholesterol or triglycerides. Pristiq may increase cholesterol or triglycerides in certain people. If you’ve had high cholesterol or triglycerides or take medication to treat these conditions, tell your doctor. They may recommend more frequent blood tests to check levels of these substances while you’re taking Pristiq.

Alcohol and Pristiq

You should not take Pristiq with alcohol. Alcohol may increase your risk of side effects and may make depression worse.

Before you start taking Pristiq, tell your doctor if you drink alcohol. They may suggest ways to stop drinking or recommend a different medication for you.

Pregnancy and breastfeeding while taking Pristiq

Before taking Pristiq, talk with your doctor if you are pregnant or plan to become pregnant. They can help you decide if Pristiq is the best choice for you during this time.

Certain antidepressants can increase the risk of preeclampsia or bleeding complications during pregnancy. Taking Pristiq in the third trimester of pregnancy may cause withdrawal symptoms in your newborn.

If you become pregnant during treatment with Pristiq, ask your doctor about registering with the National Pregnancy Registry for Antidepressants. This registry gathers data from people who’ve taken Pristiq while pregnant. This data can help determine the safety of taking antidepressants such as Pristiq during pregnancy.

Small amounts of Pristiq may pass into breast milk. But it’s not known if Pristiq is safe to take during breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about ways to safely feed your child during treatment with Pristiq.

Pristiq may help treat your depression symptoms. Some people have mild side effects from the drug, such as nausea and constipation. More serious side effects from Pristiq aren’t common.

If you have questions about Pristiq’s side effects, talk with your doctor or pharmacist. Here are a few questions to ask about treatment with Pristiq:

• Is my risk of sexual side effects higher when I first start treatment?
• Does my risk of nausea and vomiting depend on what dose I take?
• Does Pristiq have more side effects than other drugs that treat my condition?

For tips on managing your mental health, sign up for Healthline’s anxiety and depression newsletter.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

What They Are and How to Manage Them

If you have depression, your doctor might suggest Pristiq as a treatment option for you.

Pristiq is a prescription drug that’s used to treat major depressive disorder in adults.

The active ingredient in Pristiq is desvenlafaxine. An active ingredient is what makes a drug work. Pristiq comes as a tablet that you swallow. It’s usually taken long term.

For more information about Pristiq, including details about its uses, see this in-depth article.

Like other drugs, Pristiq can cause mild to serious side effects. Keep reading to learn more.

Some people may experience mild to serious side effects during Pristiq treatment. Examples of Pristiq’s commonly reported side effects include:

• dizziness
• trouble sleeping
• increased sweating
• loss of appetite
• nausea*

* To learn more about this side effect, see the “Side effects explained” section below.

Read on to learn about other potential mild and serious side effects of Pristiq.

Pristiq may cause mild side effects. Examples of mild side effects that have been reported with Pristiq include:

• dizziness
• vomiting
• trouble sleeping
• increased sweating
• drowsiness
• loss of appetite
• anxiety
• dry mouth
• sexual side effects*
• nausea*
• headache*
• constipation*
• mild allergic reaction*

* To learn more about this side effect, see the “Side effects explained” section below.

In most cases, these side effects should be temporary. And some may be easily managed, too. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. And do not stop taking Pristiq unless your doctor recommends it.

Pristiq may cause mild side effects other than the ones listed above. See the Pristiq prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Pristiq, visit MedWatch.

Pristiq can cause serious side effects, though these are usually rare. Serious side effects that have been reported with Pristiq are listed below. Some of these side effects were reported in studies of Pristiq. But others were reported after the drug became available on the market.

• increased blood pressure
• mania and hypomania, which cause elevated mood
• serotonin syndrome, resulting from a buildup of the chemical serotonin
• increased risk of bleeding, which may be life threatening
• angle-closure glaucoma, a serious eye condition
• discontinuation syndrome, which causes withdrawal symptoms
• seizures
• low level of sodium in the blood
• risk of suicidal thoughts and actions*
• severe allergic reaction†‡

* Pristiq has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effects explained” section below.
† To learn more about this side effect, see the “Side effects explained” section below.
‡ An allergic reaction is possible after taking Pristiq. But this side effect wasn’t reported in studies.

If you develop serious side effects while taking Pristiq, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Get answers to some frequently asked questions about Pristiq’s side effects.

Does Pristiq cause weight gain?

It’s possible. In studies of Pristiq, weight gain was not a reported side effect. But after Pristiq was made available on the market, some people who took it reported gaining weight.

It’s important to note that weight changes, including weight gain, can be a symptom of depression.

If you experience weight gain while taking Pristiq, talk with your doctor. They may have tips to help with this side effect.

If I suddenly stop taking Pristiq, will I have withdrawal symptoms?

Yes, it’s possible. Withdrawal symptoms may be a side effect of stopping Pristiq, and they can be mild or serious. Some of the mild symptoms of withdrawal include:

• nausea
• sweating
• dizziness
• headache
• trouble sleeping
• “brain zaps” (feeling an electrical jolt in the head that may travel to other parts of the body)
• irritability, anxiety, or agitation

Some serious symptoms of withdrawal include:

• seizure
• suicidal thoughts
• severe aggression
• increased blood pressure
• blurry vision

These side effects are more likely to happen if you stop taking Pristiq suddenly. If you want to stop taking Pristiq, talk with your doctor first. They’ll likely recommend that you take a smaller dose for a while rather than stopping Pristiq abruptly. It may take several months to stop taking Pristiq completely.

Will my risk of side effects be higher with the 100-mg dose of Pristiq than with lower doses of the drug?

It’s possible. During studies of Pristiq, people took different doses of the drug. The side effects that were reported were the same for each dosage. But more people who took the 100-milligram (mg) dose reported certain side effects than those who took the 50-mg dose. Some of these side effects were:

• dry mouth
• sleepiness
• trouble sleeping
• certain sexual side effects*
• nausea*

* To learn more about this side effect, see the “Side effects explained” section below.

Learn more about some of the side effects Pristiq may cause.

Risk of suicidal thoughts and actions

Pristiq carries a boxed warning about the risk of suicidal thoughts and actions in children, adolescents, and adults ages 24 years and younger. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Antidepressants such as Pristiq may increase the risk of suicidal thoughts and actions in people under 25 years of age. The FDA has not approved the use of Pristiq in people ages 18 years or younger.

Symptoms of suicidal thoughts and actions include:

• sudden changes in mood, behaviors, thoughts, or feelings
• trouble sleeping
• new or worsened irritability or depression
• extreme anger, violence, or aggression
• extreme increase in talking, excitement, and activity, which can result from mania
• panic attack
• impulsive behavior
• thoughts about dying or hurting yourself
• suicide attempts

What might help

Keep track of how you feel while taking Pristiq. If you experience any of the symptoms listed above while taking Pristiq, tell your doctor right away.

Consider letting people close to you know about this Pristiq side effect and its symptoms. They can also help you watch out for these symptoms.

If you’re 18 to 24 years of age, your doctor may monitor you more closely for symptoms of suicidal thoughts and actions during Pristiq treatment.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The Suicide and Crisis Lifeline is available 24 hours per day when you call 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 and then 800-273-8255.

Click here for more links and local resources.

Sexual side effects

Antidepressants such as Pristiq may cause sexual side effects. In studies of the drug, males* reported:

• decreased libido
• problems getting an erection
• delayed ejaculation

In studies of the drug, females* reported:

• not being able to reach orgasm
• decreased libido

* In this article, we use the terms “male” and “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

What might help

Over time, sexual side effects may lessen on their own. Sometimes, switching to a different antidepressant may help. If you experience any sexual side effects while taking Pristiq, tell your doctor. They can suggest ways to help ease sexual side effects.

Nausea

In studies, nausea was a common side effect of Pristiq. By itself, nausea may be considered a mild side effect. But it can be a symptom of withdrawal, which may occur if you stop taking Pristiq suddenly. (For more information, see the “FAQs about Pristiq’s side effects” section above.)

Nausea may also be a symptom of serotonin syndrome. This is a serious condition that can happen when too much serotonin builds up in the body.

Other symptoms of serotonin syndrome include:

• confusion
• agitation
• dizziness
• racing heartbeat or changes in blood pressure
• flushing (temporary warmth, redness, or deepening of skin color) or sweating
• seizure
• muscle twitching or tremors
• seeing or hearing things that aren’t real
• increased body temperature
• severe vomiting or diarrhea
• coma

What might help

If you have nausea with Pristiq, the following tips may help ease this side effect:

• Take your dose with some crackers or toast.
• Try drinks or foods that contain ginger.
• Ask your doctor about medications that can help decrease nausea.

If your nausea is severe or occurs with the symptoms of serotonin syndrome listed above, seek immediate medical care.

Headache

Headache was a common side effect in short-term studies of Pristiq. This side effect was usually mild.

This side effect may also occur if you suddenly stop Pristiq. (For more information, see the “FAQs about Pristiq’s side effects” section above.)

Headaches may be a symptom of a low blood level of sodium. This is a side effect of certain antidepressants such as Pristiq, and it can be a serious problem. Older adults (ages 65 years and older) and people who take diuretics may have a higher risk of this side effect. Symptoms to watch out for include:

• confusion
• problems with concentration or memory
• feeling weak and unsteady
• seeing or hearing things that aren’t real
• seizure
• fainting
• coma

What might help

Mild headaches may lessen a few weeks after starting Pristiq. But if this side effect continues to bother you, talk with your doctor. They may recommend medications to treat your headaches.

If your headaches occur with the other symptoms of a low blood level of sodium listed above, seek immediate medical treatment.

Constipation

Constipation was a common, mild side effect in studies of Pristiq.

What might help

Constipation usually goes away after taking Pristiq for a few weeks. Drinking more water and mild exercise may help with this side effect.

If you experience constipation that becomes severe, talk with your doctor. They may recommend changes in your diet or medications to help relieve this side effect.

Allergic reaction

Like most drugs, Pristiq can cause an allergic reaction in some people. But this side effect wasn’t reported in studies.

Symptoms can be mild to serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, usually in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest treatment options to manage your symptoms. Examples include:

• an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
• a product you apply to your skin, such as hydrocortisone cream

If your doctor confirms you’ve had a mild allergic reaction to Pristiq, they’ll decide if you should continue taking it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Pristiq, they may have you switch to a different treatment.

Keeping track of side effects

During your Pristiq treatment, consider taking notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful when you first start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of the drug you were taking when you had the side effect
• how soon you had the side effect after starting that dose
• what your symptoms were
• how it affected your daily activities
• what other medications you were taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help them learn more about how Pristiq affects you. They can then use this information to adjust your treatment plan if needed.

Pristiq comes with several warnings.

Boxed warning: Risk of suicidal thoughts and actions

Pristiq has a boxed warning for the risk of suicidal thoughts and actions in children, adolescents, and adults ages 24 years and younger. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

To learn more, see the “Side effects explained” section above.

Other warnings

Pristiq may cause drug-condition interactions. This means that Pristiq may not be right for you if you have certain medical conditions. Other factors may also affect whether Pristiq is a good treatment option for you.

Talk with your doctor about your health history before starting Pristiq. The list below includes factors to consider.

High blood pressure. Pristiq can cause your blood pressure to increase.If you have high blood pressure, your doctor may prescribe medication to treat it before you start taking Pristiq. Then they’ll monitor your blood pressure to make sure it’s well-managed. If your blood pressure remains high, your doctor may adjust your dosage of Pristiq or recommend a different antidepressant.

Heart disease. If you have heart disease, Pristiq may make it worse. Pristiq can increase your blood pressure, which may worsen heart disease. If you have a history of heart disease or high blood pressure, tell your doctor before starting Pristiq treatment.

Stroke or ministroke. Pristiq can increase your blood pressure, so it may increase your risk of stroke if you’ve had one before. If you’ve had a stroke or if you’ve had any problems with high blood pressure, let your doctor know. This will help them determine whether it’s safe for you to take Pristiq.

Bleeding problems. Medications like Pristiq may increase your risk of bleeding. If you take medications that increase bleeding, your risk may be greater. Before you take Pristiq, make sure your doctor knows all of the medications you take.

Angle-closure glaucoma. Pristiq may cause dilation of the pupils in the eye. This can cause an episode of glaucoma in certain people. Because of this, doctors will likely not prescribe Pristiq to anyone with this kind of glaucoma. If you have a history of glaucoma or if you take any eye drops for glaucoma, tell your doctor. They’ll discuss with you treatment options that are safe for you to take.

Mania, hypomania, or bipolar disorder. Pristiq may not be the right medication for people who have had mania, hypomania, or bipolar disorder. It also may not be safe for people who have a family history of these mental health conditions. If you have bipolar disorder, Pristiq can increase your risk of a manic episode. Before you start Pristiq treatment, tell your doctor about any mental health conditions you or close family members have had.

Allergic reaction. If you’ve had an allergic reaction to Pristiq or any of its ingredients, your doctor will likely not prescribe Pristiq. Ask them what other medications are better options for you.

Seizures or epilepsy. Pristiq was not studied in people with a history of seizures or epilepsy. If you’ve ever had a seizure or have epilepsy, tell your doctor. They’ll let you know if Pristiq is safe for you to take.

Low sodium level. Pristiq can lower the blood level of sodium, which can become a serious problem. Older adults (ages 65 years and older) or people who take diuretics may have a higher risk of this side effect. If you are an older adult or take a diuretic, or have had problems with a low sodium level in the past, your doctor will let you know whether it’s safe to take Pristiq.

Liver problems. If you have liver problems, your body may have trouble getting rid of Pristiq. Before you start treatment, tell your doctor about any liver problems you have or have had. They may prescribe a lower dosage of Pristiq.

Kidney problems. If you have kidney problems, your body may have trouble getting rid of Pristiq. Before you start treatment, tell your doctor about any kidney problems you have or have had. They may recommend that you take a lower dosage of Pristiq.

High cholesterol or triglycerides. Pristiq may increase cholesterol or triglycerides in certain people. If you’ve had high cholesterol or triglycerides or take medication to treat these conditions, tell your doctor. They may recommend more frequent blood tests to check levels of these substances while you’re taking Pristiq.

Alcohol and Pristiq

You should not take Pristiq with alcohol. Alcohol may increase your risk of side effects and may make depression worse.

Before you start taking Pristiq, tell your doctor if you drink alcohol. They may suggest ways to stop drinking or recommend a different medication for you.

Pregnancy and breastfeeding while taking Pristiq

Before taking Pristiq, talk with your doctor if you are pregnant or plan to become pregnant. They can help you decide if Pristiq is the best choice for you during this time.

Certain antidepressants can increase the risk of preeclampsia or bleeding complications during pregnancy. Taking Pristiq in the third trimester of pregnancy may cause withdrawal symptoms in your newborn.

If you become pregnant during treatment with Pristiq, ask your doctor about registering with the National Pregnancy Registry for Antidepressants. This registry gathers data from people who’ve taken Pristiq while pregnant. This data can help determine the safety of taking antidepressants such as Pristiq during pregnancy.

Small amounts of Pristiq may pass into breast milk. But it’s not known if Pristiq is safe to take during breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about ways to safely feed your child during treatment with Pristiq.

Pristiq may help treat your depression symptoms. Some people have mild side effects from the drug, such as nausea and constipation. More serious side effects from Pristiq aren’t common.

If you have questions about Pristiq’s side effects, talk with your doctor or pharmacist. Here are a few questions to ask about treatment with Pristiq:

• Is my risk of sexual side effects higher when I first start treatment?
• Does my risk of nausea and vomiting depend on what dose I take?
• Does Pristiq have more side effects than other drugs that treat my condition?

For tips on managing your mental health, sign up for Healthline’s anxiety and depression newsletter.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

16 Weight Loss Antidepressants

23 Lips, 2020 od Adrian

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Overview

Weight gain is a possible side effect of many antidepressants. Although each person responds differently to antidepressant treatment, subsequent antidepressants may cause weight gain during treatment.

Tricyclic antidepressants, also known as cyclic antidepressants or TCAs, may cause weight gain. These medicines include:

• amitriptyline (Elavil)
• amoxapine
• desipramine (norpramine)
• doxepin (adapin)
• imipramine (Tofranil-PM)
• nortriptyline (Pamelor)
• protriptyline (Vivaktil)
• trimipramine (Surmontil)

TCAs were among the first drugs approved for the treatment of depression. They are no longer prescribed as often because newer treatments cause fewer side effects.

According to study 19At 84, weight gain was a common reason people stopped taking these types of antidepressants. study.

However, TCAs may be effective in people who do not respond to other types of antidepressants despite side effects.

Monoamine oxidase inhibitors (MAOIs) were the first class of antidepressants to be developed. MAOs that cause weight gain include:

• phenelzine (Nardil)
• isocarboxazid (Marplan)
• tranylcypromine (parnate)

Doctors most often prescribe MAOIs when other antidepressants do not work due to certain side effects and safety concerns. Of the three MAOIs listed above, pheneline is the most likely to cause weight gain, according to 1988 data. preliminary.

However, a newer form of MAOIs known as selegiline (Emsam) has been shown to cause weight loss during treatment. Emsam is a transdermal drug that is applied to the skin with a patch.

SSRIs are the most commonly prescribed class of drugs for depression. Long-term use of the following SSRIs may cause weight gain:

• paroxetine (Paxil, Pexeva, Brisdel)
• sertraline (Zoloft)
• fluoxetine (Prozac)
• citalopram (Celexa)

Although some SSRIs are initially associated with weight loss , long-term use of SSRIs is mainly associated with weight gain. Long-term use is considered treatment lasting more than six months.

Of the above SSRIs, paroxetine is most commonly associated with weight gain in both long-term and short-term use.

4. Some atypical antidepressants

Mirtazapine (Remeron) is a noradrenergic antagonist that is a type of atypical antidepressant. The drug has been shown several times more likely to cause weight gain and increase appetite than other drugs.

Mirtazapine is less likely to make people gain weight than TCAs.

It also does not cause as many other side effects as other antidepressants. However, it may cause:

• nausea
• vomiting
• sexual dysfunction

Other antidepressants are associated with less weight gain as a side effect. These antidepressants include:

• escitalopram (Lexapro, Cipralex), SSRI
• duloxetine (Cymbalta), a serotonin and norepinephrine reuptake inhibitor (SNRI), may cause moderate weight gain. long-term use
• bupropion (Wellbutrin, Forfivo and Aplenzin), an atypical antidepressant
• nefazodone (serzone), a serotonin antagonist and reuptake inhibitor
• venlafaxine (Effexor) and venlafaxine ER (Effexor XR), both of which are SNRIs
• desvenlafaxine (Pristiq ), SNRI
• levomilnacipran (Fetzima), SNRI
• vilazodone (Viibryd), serotonergic antidepressant
• vortioxetine (Trintellix), atypical antidepressant
• selegiline (Emsam), a new you apply to the skin, which may result in less more side effects than oral MAOIs.

Weight gain is also less likely if the following SSRIs are taken for less than six months: 2 Not everyone will take antidepressants to gain weight. Some people will actually lose weight.

Experts emphasize that concerns about weight gain should not influence the choice of antidepressants in most people. There are other side effects and factors to consider when choosing an antidepressant.

If you gain weight while taking an antidepressant, the drug may not be the direct cause of the weight gain. For example, improving mood when taking antidepressants can increase appetite, leading to weight gain.

Do not stop taking your medicine right away, even if you are a little older. You will need to work with your doctor to find an antidepressant that helps with depressive symptoms and does not cause unwanted side effects. This may take a little patience.

Your doctor can also give you some advice on how to prevent weight gain while on antidepressants.

Weight loss antidepressants – Weight Management

Disclaimer

If you have any medical questions or concerns, contact your physician. Articles in the Health Guide are based on peer-reviewed research and information from medical societies and government agencies. However, they are not a substitute for professional medical advice, diagnosis or treatment.

If you have been prescribed an antidepressant, you may be curious about its potential effect on weight, especially if it causes weight gain or loss. Here’s what the study says about how antidepressant use can affect what you see on the scale.

Do some antidepressants cause weight loss?

There are over a dozen antidepressants commonly prescribed. But only one has been consistently linked to weight loss in studies: bupropion (brand name Wellbutrin).

K A 2019 meta-analysis of 27 studies looking at antidepressants and weight gain found that antidepressant use can increase body weight by an average of 5%, excluding bupropion, which has been associated with weight loss (Alonso-Pedrero, 2019 ).

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Another 2016 study looked at the long-term weight loss effects of various antidepressants and found that non-smokers taking bupropion lost 7.1 pounds in two years. (This effect was not observed in smokers.) Users of other antidepressants in the study gained weight (Arterburn, 2016).

Bupropion also helps support weight loss. A 2012 study found that obese adults who took bupropion SR (standard release) at doses of 300 or 400 mg lost 7.2% and 10% of their body weight, respectively, at 24 weeks and retained most of that weight loss at 48 weeks. (Anderson, 2012).

In fact, bupropion is part of the popular weight loss drug naltrexone-bupropion (brand name Contrave), approved by the FDA to treat overweight or obesity.

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Why do antidepressants affect weight?

Experts are not exactly sure. The effect of antidepressants on weight, according to one study, is only partially understood and poorly described (Gafoor, 2018).

In a very broad sense, antidepressants act on various chemicals, neurotransmitters, and receptors in the brain. This changes the level of exposure of these neurotransmitters to the brain. Ideally, this improves mental health issues such as depression and anxiety. In some cases, not ideally, these effects seem to cause metabolic changes that lead to weight gain.

For example: Bupropion is a drug known as an NDRI (norepinephrine-dopamine reuptake inhibitor). It prevents the brain from absorbing free-floating norepinephrine (aka adrenaline) and dopamine (also known as the feel-good hormone). When they are not reabsorbed quickly, adrenaline and dopamine stay and act on the brain for longer. This can affect metabolism and appetite, leading to weight loss.

Some antidepressants affect histamine and serotonin, which regulate appetite (Gill, 2020). Others act on neurotransmitters and receptors that are associated with weight gain (David, 2016). Some of these drugs, mostly first-generation tricyclic antidepressants, can change the way the body metabolizes lipids (fats) and glucose (blood sugar) (Hasnain, 2012; David, 2016).

However, weight gain or loss is far from guaranteed with antidepressants.

Fear of gaining weight should not prevent you from taking antidepressants if you need them. If you are concerned about weight gain, check with your doctor. Effective solutions may include adjusting diet, increasing exercise, or, in some cases, changing medications.

Weight loss diets: what are the most effective?

8 minutes to read

Symptoms of Depression

Latest Diagnostic and Statistical Manual of Mental Disorders (DSM 5) defines major depressive disorder (MDD) as two or more weeks of five of the following symptoms that cause problems with social, occupational, or other activities:

• Depressed
• Decreased interest or pleasure in activities weight gain or weight gain or increased or decreased appetite
• Insomnia or too much sleep
• Slow movement, fussiness or restlessness
• Fatigue or loss of energy
• Feeling excessive guilt or worthlessness
• Problems concentrating or making decisions
• Recurrent thoughts of death or suicide (DSM, 2013)

Do not hesitate to seek medical help if you or someone you know is suffering from depression.

Treating depression

In some cases, depression may have a medical cause, such as hypothyroidism, vitamin B12 deficiency, low testosterone, or drug side effects. The health care provider can diagnose and treat them.

Unfortunately, most depression is not caused by a medical problem. For depression without a medical cause, medications and psychotherapy are the main treatments.

Antidepressants

The most common antidepressants are selective serotonin reuptake inhibitors (SSRIs), which include fluoxetine (brand name Prozac), sertraline (brand name Zoloft), paroxetine (brand name Paxil), and escitalopram (brand name Lexapro).

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are also commonly prescribed, including venlafaxine (brand name Effexor), duloxetine (brand name Cymbalta), and desvenlafaxine (brand name Pristiq).

Talk to your doctor to find the right medicine for you.

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Therapy

Studies show that antidepressants and cognitive behavioral therapy (CBT) are about equally effective in treating depression. However, CBT may have longer lasting effects and prevent relapse (Hollon, 2005). During CBT, therapists encourage patients to replace negative, unhelpful thoughts with more positive ones.

Diet and exercise

Both aerobic and resistance exercise have been found to be effective in relieving depression (Craft, 2004). Some studies indicate that the Mediterranean diet is associated with lower levels of depression (Sánchez-Villegas, 2009).

Other things that can improve depression include better sleep, increased social interaction, and avoiding excessive alcohol and tobacco use.

Seek the depression help you need

If you feel overwhelmed, it is important to seek help. Talk to your doctor or psychiatrist to find out if antidepressants, therapy, or a combination is right for you. If you are concerned about weight gain on antidepressants, be sure to discuss this with your healthcare provider.

Recommendations

1. Alonso-Pedrero, L. , Bes-Rastrollo, M., and Marty, A. (2019). Effects of antidepressants and antipsychotics on weight gain: a systematic review. Obesity Reviews: Official Journal of the International Association for the Study of Obesity , twenty (12), 1680–1690. DOI: 10.1111 / fig.12934. Retrieved from https://pubmed.ncbi.nlm.nih.gov/31524318/
2. Craft, L. L. and Pern, F. M. (2004). Benefits of exercise for patients with clinical depression. Primary Health Care Assistant to the Journal of Clinical Psychiatry, 06 (03), 104–111. DOI: 10.4088 / pcc.v06n0301. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15361924/
3. David, D. J., & Gurion, D. (2016). Antidepressants and tolerance: determinants and treatment of major side effects. L’Encephale, 42 (6), 553–561. https://doi.org/10.1016/j.encep.2016.05.006. Retrieved from https://pubmed.ncbi.nlm.nih.gov/27423475/
4. DSM-5 (2013). depressive disorders. Diagnostic and Statistical Manual of Mental Disorders DOI: 10. 1176/appi.books.9780890425596.dsm04. https://dsm.psychiatryonline.org/doi/book/10.1176/appi.books.9780890425596
5. Gafur R., Booth H. P. & Gulliford M. K. (2018). Antidepressant use and incidence of weight gain over 10 years of follow-up: a population-based cohort study. BMJ (Clinical Investigation Edition), 361 , 1951. https://doi.org/10.1136/bmj.k1951. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29793997/
6. Gill, H., Gill, B., El-Halabi, S., Chen-Li, D., Lipsitz, O., Rosenblat , J.D., et al. (2020). Antidepressants and weight change: an overview review. Obesity, 28 (11), 2064–2072. DOI: 10.1002 / oby.22969. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22969
7. Hasnain, M., Veueg, V. V., and Hallett, B. (2012). Weight gain and glucose dysregulation with antipsychotics and second-generation antidepressants: a review for primary care physicians. Postgraduate, 124 (4), 154–167. https://doi.org/10.3810/pgm.2012.