What are the active ingredients in Advil Cold & Sinus. How does this medication work to relieve cold and sinus symptoms. What are the recommended dosages for adults and children. Who should not take Advil Cold & Sinus.

Understanding Advil Cold & Sinus: Composition and Mechanism of Action

Advil Cold & Sinus is a combination medication designed to provide relief from various cold and sinus symptoms. It contains two active ingredients: ibuprofen and pseudoephedrine. Each plays a specific role in addressing different aspects of cold and sinus discomfort.

Ibuprofen: The Pain and Fever Fighter

Ibuprofen belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing the production of prostaglandins, substances in the body that contribute to inflammation, pain, and fever. By inhibiting these prostaglandins, ibuprofen effectively:

• Alleviates pain associated with colds and sinus infections
• Reduces fever
• Decreases inflammation in the nasal passages and sinuses

Pseudoephedrine: The Decongestant

Pseudoephedrine is a decongestant that targets nasal and sinus congestion. It works by:

• Constricting blood vessels in the nasal passages
• Reducing swelling in the nasal and sinus tissues
• Promoting drainage of mucus from the sinuses

This combination of effects helps to clear blocked nasal passages and relieve the pressure often associated with sinus congestion.

Available Forms and Formulations of Advil Cold & Sinus

Advil Cold & Sinus comes in various forms to suit different preferences and needs. The available formulations include:

1. Liqui-Gels: Light gold, liquid-filled gelatin capsules
2. Caplets: Beige, sugar-coated tablets
3. Daytime Caplets: Similar to regular caplets but formulated for daytime use

Each form contains 200 mg of ibuprofen and 30 mg of pseudoephedrine as the active ingredients. The different formulations may contain varying inactive ingredients to enhance stability, absorption, and ease of use.

Inactive Ingredients and Their Purpose

While the active ingredients provide the therapeutic effects, the inactive ingredients serve various functions:

• Gelatin (in Liqui-Gels): Forms the capsule shell
• Cellulose and cornstarch: Act as fillers and binders
• Titanium dioxide and iron oxides: Provide coloring
• Carnauba wax: Adds a protective coating
• Croscarmellose sodium: Aids in disintegration of the tablet

These inactive ingredients help to ensure the medication’s stability, ease of swallowing, and proper dissolution in the body.

Proper Usage and Dosage Guidelines for Advil Cold & Sinus

To achieve optimal relief from cold and sinus symptoms while minimizing the risk of side effects, it’s crucial to follow the recommended dosage guidelines for Advil Cold & Sinus.

Adult Dosage

For adults and children over 12 years of age, the standard dosage is:

• 1 or 2 caplets or liqui-gels every 4 to 6 hours as needed
• Do not exceed 6 caplets or liqui-gels in a 24-hour period
• Limit use to 3 days for fever or 5 days for cold symptoms, unless directed otherwise by a healthcare professional

Children’s Dosage

For children under 12, a suspension form is available. The dosage depends on the child’s age and weight:

• Administer every 6 hours as needed
• Do not exceed 4 doses in 24 hours
• Use an oral syringe or medication cup for accurate measurement
• Shake the suspension well before each use

Is it safe to give Advil Cold & Sinus to children under 12? It’s important to consult with a pediatrician before administering this medication to young children, as they may be more sensitive to its effects and require different dosing.

Precautions and Contraindications for Advil Cold & Sinus Use

While Advil Cold & Sinus can provide effective relief for many individuals, it’s not suitable for everyone. Certain medical conditions and factors may increase the risk of adverse effects or interactions.

Who Should Avoid Advil Cold & Sinus?

The following groups should not use Advil Cold & Sinus:

• Individuals allergic to ibuprofen, pseudoephedrine, or any ingredients in the medication
• Those allergic to other NSAIDs or aspirin
• Patients about to have or recovering from heart surgery
• People who are dehydrated due to vomiting, diarrhea, or insufficient fluid intake
• Individuals already taking another NSAID
• Pregnant or breastfeeding women
• Those with stomach ulcers or intestinal bleeding

Why is Advil Cold & Sinus not recommended during pregnancy or breastfeeding? NSAIDs like ibuprofen may pose risks to fetal development, particularly in the third trimester, and can be passed through breast milk. Pseudoephedrine may also affect milk production in nursing mothers.

Potential Side Effects and Interactions of Advil Cold & Sinus

As with any medication, Advil Cold & Sinus can cause side effects in some individuals. It’s important to be aware of these potential effects and to discontinue use and seek medical attention if severe symptoms occur.

Common Side Effects

Some users may experience:

• Stomach upset or nausea
• Heartburn
• Dizziness or lightheadedness
• Nervousness or restlessness
• Difficulty sleeping

Serious Side Effects

While rare, some individuals may experience more severe reactions, such as:

• Allergic reactions (rash, itching, swelling)
• Stomach bleeding
• Cardiovascular events (especially in those with pre-existing conditions)
• Changes in blood pressure
• Kidney problems

Can Advil Cold & Sinus interact with other medications? Yes, it can interact with various drugs, including:

• Blood thinners (e.g., warfarin)
• Other NSAIDs
• Certain antidepressants
• Some blood pressure medications

Always consult with a healthcare provider or pharmacist about potential interactions before starting Advil Cold & Sinus, especially if you’re taking other medications.

Proper Storage and Disposal of Advil Cold & Sinus

To maintain the effectiveness and safety of Advil Cold & Sinus, proper storage and disposal practices are essential.

Storage Guidelines

• Store at room temperature
• Keep away from direct sunlight and excessive heat
• Protect from moisture
• Keep out of reach of children and pets

Disposal Methods

When disposing of unused or expired Advil Cold & Sinus:

• Do not flush down the toilet or sink
• Do not throw in household trash
• Use community drug take-back programs if available
• Consult a pharmacist for proper disposal methods in your area

Why is proper disposal of medications important? Improper disposal can lead to environmental contamination and potential misuse by others. Following recommended disposal methods helps protect both the environment and public health.

Alternatives and Complementary Treatments for Cold and Sinus Relief

While Advil Cold & Sinus can be effective for many people, some may prefer alternative or complementary approaches to managing cold and sinus symptoms.

Over-the-Counter Alternatives

• Acetaminophen-based cold and sinus medications
• Nasal sprays (saline or medicated)
• Throat lozenges
• Single-ingredient decongestants or pain relievers

Natural Remedies

Some individuals find relief through natural methods, such as:

• Steam inhalation
• Neti pot or nasal irrigation
• Herbal teas (e.g., ginger, echinacea)
• Vitamin C and zinc supplements
• Rest and increased fluid intake

Are natural remedies as effective as Advil Cold & Sinus? While some natural remedies may provide symptomatic relief, their effectiveness can vary widely between individuals. They may be most beneficial when used in conjunction with proper rest and hydration.

Lifestyle Modifications

In addition to medication or natural remedies, certain lifestyle changes can support recovery and symptom management:

• Getting adequate sleep
• Staying hydrated
• Using a humidifier
• Avoiding irritants like smoke or strong odors
• Practicing good hand hygiene to prevent spread of infection

By combining appropriate medication use with lifestyle modifications and complementary treatments, many individuals can effectively manage their cold and sinus symptoms and promote faster recovery.

In conclusion, Advil Cold & Sinus offers a combination of pain relief and decongestant properties that can effectively alleviate various cold and sinus symptoms. However, it’s crucial to use this medication responsibly, following recommended dosages and being aware of potential side effects and interactions. For those who cannot use Advil Cold & Sinus or prefer alternative approaches, numerous other options exist for managing cold and sinus discomfort. As with any health concern, consulting with a healthcare professional can help determine the most appropriate treatment strategy for individual needs and circumstances.

Advil Cold & Sinus – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

This product is a combination of 2 medications: ibuprofen and pseudoephedrine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation by reducing a substance in the body that leads to inflammation and pain. Pseudoephedrine is a decongestant that relieves the symptoms of nasal and sinus congestion by reducing swelling in nasal passages and sinuses.

This medication is used to relieve nasal congestion, sinus congestion, sinus pain, fever, headache, sore throat, and body aches and pains that are associated with the common cold, sinusitis, or the flu.

Your doctor or pharmacist may have suggested this medication for conditions other than the ones listed in this drug information article. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor or pharmacist.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor or pharmacist has not recommended it.

What form(s) does this medication come in?

Liqui-Gels

Each light gold, liquid-filled gelatin capsule contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: D&C Yellow No. 10, FD&C Red No. 40, fractionated coconut oil, gelatin, iron oxide, polyethylene glycol, polyvinyl acetate phthalate, potassium hydroxide, propylene glycol, purified water, sorbitan, and sorbitol.

Caplets

Each beige, sugar-coated caplet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: acetylated monoglyceride, ammonium hydroxide, carnauba wax, cellulose, cornstarch, croscarmellose sodium, iron oxides, parabens, pharmaceutical glaze, pharmaceutical shellac, povidone, pregelatinized starch, silicon dioxide, sodium benzoate, sodium lauryl sulfate, stearic acid, sucrose, and titanium dioxide.

Daytime

Each caplet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: acetylated monoglycerides, carnauba wax, cellulose, cornstarch, croscarmellose sodium, ethoxyethanol, iron oxides, lecithin, parabens, pharmaceutical glaze, pharmaceutical shellac, povidone, pregelatinized starch, silicon dioxide, simethicone, sodium benzoate, sodium lauryl sulfate, stearic acid, sucrose, and titanium dioxide.

How should I use this medication?

The usual recommended dose for adults and children older than 12 years is 1 or 2 caplets or liqui-gels every 4 to 6 hours as needed. Do not take more than 6 caplets or liqui-gels in 24 hours unless recommended by your doctor. Do not take for more than 3 days for a fever or for more than 5 days for cold symptoms.

For the children’s suspension, the dose depends on the child’s age and weight and is given every 6 hours as needed. Do not give more than 4 doses a day unless recommended by your doctor. Use an oral syringe or medication cup to measure each dose of the suspension, as it gives a more accurate measurement than household teaspoons. Shake the suspension well before measuring a dose.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as recommended by your doctor or pharmacist. If you are taking this medication regularly and you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

• are allergic or sensitive to ibuprofen, pseudoephedrine, or any ingredients of the medication
• are allergic to other NSAIDs (e.g., naproxen, ketoprofen, diclofenac) or ASA (acetylsalicylic acid)
• are about to have or have just had heart surgery
• are dehydrated due to vomiting, diarrhea, or not drinking enough fluids
• are taking another NSAID (e.g., naproxen, diclofenac, ketoprofen)
• are pregnant or breast-feeding
• have a stomach ulcer, intestinal ulcer, ulcerative colitis, or Crohn’s disease
• have angioedema syndrome
• have experienced wheezing or difficulty breathing from ASA or other NSAIDs (e. g., naproxen, diclofenac, ketoprofen)
• have kidney disease, or reduced or worsening kidney function
• have nasal polyps
• have Raynaud’s Syndrome
• have serious liver disease or reduced liver function
• have severe heart disease
• have severe high blood pressure
• have high levels of potassium in the blood
• have systemic lupus erythematosus
• have taken a monoamine oxidase (MAO) inhibitor (e.g., phenelzine, tranylcypromine) within the last 14 days
• have thyroid disease

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• bloating or gas
• constipation
• diarrhea
• difficulty sleeping
• heartburn
• nausea
• nervousness
• vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision or other eye symptoms
• dizziness
• fast, pounding heartbeat (palpitations)
• fluid retention
• ringing in the ears
• signs of clotting problems (e. g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don ‘t stop bleeding)
• skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
• symptoms of a severe allergic reaction (difficulty breathing, hives, swelling of the mouth or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

June 8, 2021

Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.

A previous advisory on non-steroidal anti-inflammatory drugs (NSAIDs) was issued on October 30, 2020.

Allergy: Some people who are allergic to acetylsalicylic acid (ASA) or other anti-inflammatory medications also experience allergic reactions to ibuprofen. Before you take this medication, inform your doctor about any previous adverse reactions you have had to medications, especially anti-inflammatory medications. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Bleeding problems: If you have bleeding problems (e. g., hemophilia) or are taking anticoagulants (e.g., warfarin), you should not take this medication, unless recommended by your doctor.

Dependence and withdrawal: Physical dependence can occur with the use of pseudoephedrine for too long a period of time or at doses that are greater than the recommended amount. If this medication is stopped suddenly after using it for longer than recommended or at high doses, you may experience withdrawal symptoms such as anxiety, agitation, and hallucinations. If you have been taking this medication for a while, it should be stopped gradually as directed by your doctor.

Diabetes: Ibuprofen – pseudoephedrine may cause a loss of blood glucose control, and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Drowsiness and dizziness: This medication can cause drowsiness and dizziness that may affect your ability to drive or operate machinery safely. If this medication affects you this way, do not perform these tasks.

Fluid retention: This medication can cause fluid retention. If you have heart failure or high blood pressure, fluid retention may worsen your condition. If you notice worsening of the symptoms of heart failure or your blood pressure increases while taking this medication, contact your doctor.

General: If your symptoms do not improve, contact your doctor. Do not use this medication for longer than 3 days for a fever or 5 days for pain or cold symptoms without consulting your doctor or pharmacist.

Glaucoma: This medication may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.

Heart problems: The cardiovascular system (heart and blood vessels) may be affected by the use of this medication. Ibuprofen can cause fluid to build up in the body. This alone can cause increased blood pressure and symptoms of congestive heart failure to become worse.

Pseudoephedrine can cause blood vessels to narrow, increasing blood pressure. It may also cause increased heart rate or irregular heartbeat. If you have a history of heart attack, angina, stroke or other conditions that can be worsened by changes to the heart and blood vessels, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney problems:  This medication may cause kidney problems. If you have reduced kidney function, heart failure, are taking diuretics (e. g., hydrochlorothiazide, furosemide), or are a senior, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Although rare, people taking ibuprofen-pseudoephedrine may have changes in liver function that produce abnormal liver test results. If you have a history of liver problems, discuss with your doctor or pharmacist how this medication may affect your medical condition and whether any special monitoring is needed.

Stomach ulcers and bleeding: Ibuprofen may cause ulcers or bleeding in the stomach or intestines. If you experience black, tarry stools, vomit that looks like coffee grounds, or stomach pain while taking this medication, contact your doctor immediately. If you have a history of stomach problems, discuss with your doctor or pharmacist how this medication may affect your medical condition and whether any special monitoring is needed.

Thyroid problems: If you have a thyroid condition, this medication may cause symptoms of overactive thyroid. If you are taking medications for an overactive thyroid or experience symptoms such as feeling hot all the time, weight loss without a change in your diet or amount of exercise you get, or feeling emotional, contact your doctor.

Urinary tract problems: This medication may cause bladder pain, painful or difficult urination, or increased frequency of urination. If you have an enlarged prostate gland, the difficulty urinating may be more pronounced. If these symptoms occur without an explanation (e.g., infection), stop taking this medication and contact your doctor.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication should not be used while breast-feeding.

Children: The caplets and liquid-gels should not be given to children less than 12 years old. The liquid form of the medication should not be given to children less than 6 years old.

Seniors: Seniors may be more likely to experience side effects from this medication.

What other drugs could interact with this medication?

There may be an interaction between ibuprofen – pseudoephedrine and any of the following:

• acetazolamide
• acetylsalicylic acid (ASA)
• alcohol
• aliskiren
• alpha-agonists (e.g., clonidine, methyldopa)
• alpha-blockers (e.g., alfuzosin, doxazosin, silodosin, tamsulosin)
• aminoglycoside antibiotics (e.g., amikacin, gentamicin, tobramycin)
• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
• angiotensin-converting enzyme inhibitors (ACEIs; captopril, ramipril)
• angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)
• anticoagulants (e.g., dalteparin, enoxaparin, heparin, warfarin, apixaban, dabigatran, rivaroxaban)
• antipsychotics (e. g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
• atomoxetine
• “azole” antifungals (e.g., fluconazole, voriconazole)
• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• bimatoprost
• bisphosphonates (e.g., alendronate, etidronate)
• brinzolamide
• caffeine
• calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
• cannabis
• celecoxib
• cholestyramine
• clopidogrel
• colestipol
• corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
• cyclosporine
• dasatinib
• decongestant cold medications (e.g., phenylephrine, pseudoephedrine)
• decongestant eye drops and nose sprays (e.g., naphazoline, oxymetazoline, xylometazoline)
• deferasirox
• desmopressin
• dexmethylphenidate
• diabetes medications (e.g., chlorpropamide, glyburide, insulin, metformin, rosiglitazone)
• digoxin
• dipyridamole
• diuretics (e. g., hydrochlorothiazide, furosemide, triamterene)
• dorzolamide
• drospirenone
• eplerenone
• epinephrine
• ergot alkaloids (e.g., ergotamine, dihydroergotamine)
• fast-acting bronchodilators (e.g., salbutamol, terbutaline)
• fentanyl
• glucosamine
• herbs that may increase the risk of bleeding (e.g., cat’s claw, dong quai, feverfew, garlic, ginger)
• imatinib
• latanoprost
• linezolid
• lithium
• long-acting bronchodilators (e.g., formoterol, salmeterol)
• lumacaftor and ivacaftor
• MAO inhibitors (i.e., moclobemide, phenelzine, selegiline)
• methotrexate
• methylphenidate
• modafinil
• obinutuzumab
• omega-3 fatty acids
• other NSAIDs (e.g., naproxen, diclofenac, ketorolac)
• pemetrexed
• pentosan polysulfate sodium
• pentoxifylline
• prasugrel
• quinolone antibiotics (e. g., ciprofloxacin, norfloxacin, ofloxacin)
• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; desvenlafaxine, duloxetine, venlafaxine)
• sodium phosphates
• sulfasalazine
• tacrolimus
• tenofovir
• theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
• thyroid replacements (e.g., dessicated thyroid, levothyroxine)
• ticagrelor
• ticlopidine
• tipranavir
• topiramate
• tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, and street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Advil-Cold-Sinus

Common and Rare Side Effects for Advil Cold and Sinus oral

COMMON side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

RARE side effects

If experienced, these tend to have a Severe expression i

If experienced, these tend to have a Less Severe expression i

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Ibuprofen / pseudoephedrine: side effects, dosages, treatments, interactions, warnings

ibuprofen

Checked on 04/16/2020

• What is
  • What is ibuprofen/pseudoephedrine and how does it work?
• Side effects
  • What side effects are associated with the use of ibuprofen/pseudoephedrine?
• Drug interactions
  • What other drugs interact with ibuprofen/pseudoephedrine?
• Warnings and precautions
  • What are the warnings and precautions for taking ibuprofen/pseudoephedrine?

What is ibuprofen/pseudoephedrine and how does it work?

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Brand Name: Advil Cold & Sinus
Generic name: Ibuprofen/Pseudoephedrine
Drug class: Cough/cold, other combinations; Combinations of analgesics and decongestants

Ibuprofen/pseudoephedrine is an over-the-counter product used to treat the symptoms of the common cold.

Ibuprofen/pseudoephedrine is available under the following brand names: Advil Cold and Sinus.

Ibuprofen/pseudoephedrine dosages:

Formulations and strengths

Caplet

• 200 mg / 30 mg

Liquid gel capsule

• 200 mg / 30 mg

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Dosage recommendations:

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Cold symptoms

• Adults and children over 12 years: 1 capsule/capsule orally every 4-6 hours as needed; if necessary, may increase to 2 capsules / capsules every 4-6 hours until symptoms disappear.
• Do not exceed 6 doses / 24 hours
• Children under 12: safety and efficacy not established.
• Administration
• Take with food or milk if stomach upset occurs.

What side effects are associated with the use of ibuprofen/pseudoephedrine?

Ibuprofen/pseudoephedrine side effects include:

• Gastrointestinal upset
• Insomnia
• Irregular heartbeat (arrhythmia)
• Palpitations
• Convulsions
• Dizziness
• Drowsiness
• Excitability
• Headache
• Tremor
• Weak spot
• Nausea
• Vomiting
• Hemolytic anemia
• Aplastic anemia
• Bronchospasm
• Chronic heart failure
• Exfoliative dermatitis
• Constipation
• High blood pressure (hypertension)
• Low white blood cells (neutropenia)
• Thromboembolism
• Abdominal pain
• Anxiety
• Central nervous system (CNS) stimulation
• Liver toxicity
• Dizziness 90 012

This document does not contain all possible side effects that may occur. For more information about side effects, please consult your doctor.

What other medicines interact with ibuprofen/pseudoephedrine?

If you have been advised by your doctor to use this medicine, your doctor or pharmacist may already be aware of any possible drug interactions and can monitor you for them. Do not start, stop, or change the dosage of any medicine without talking to your doctor, health care provider, or pharmacist.

Severe ibuprofen/pseudoephedrine interactions include:

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• iobenguane I 123
• isocarboxazid
• linezolid
• phenelzine
• procarbazine
• rasagiline
• selegiline 9001 2
• selegiline transdermal
• tranylcypromine

Ibuprofen/pseudoephedrine has serious interactions with at least 52 different drugs.

Ibuprofen/pseudoephedrine interacts moderately with at least 293 different drugs.

Ibuprofen/pseudoephedrine interacts poorly with at least 35 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share it with your doctor and pharmacist. Check with your doctor if you have questions or health concerns.

What are the warnings and precautions for taking ibuprofen/pseudoephedrine?

Warnings

This medicine contains ibuprofen/pseudoephedrine. Do not take Advil Cold & Sinus if you are allergic to ibuprofen/pseudoephedrine or any of the ingredients in this medicine.

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Keep out of the reach of children. In case of overdose, seek medical attention or contact a Poison Control Center immediately.

Contraindications.

• Hypersensitivity
• Immediately before or after heart surgery
• History of asthma or urticaria caused by non-steroidal anti-inflammatory drugs (NSAIDs)
• Do not use with monoamine oxidase inhibitors (MAOIs) or within 2 weeks of stopping MAOIs due to risk of hypertension crisis.

Consequences of drug abuse

• No information available

Short-term effects

• See “What side effects are associated with the use of ibuprofen/pseudoephedrine?”

Long-term effects

• See What side effects are associated with the use of ibuprofen/pseudoephedrine?

Warnings

• Use with caution in hypertension, heart disease, kidney or liver failure, asthma, thyroid disease, diabetes, prostate adenoma, peptic ulcer.
• Non-steroidal anti-inflammatory drugs (NSAIDs) content
• May increase the risk of gastrointestinal ulcers, increased risk if age over 60 years or history of peptic ulcer
• Caution when used concomitantly with antiplatelet agents / anticoagulants.
• May reduce the effectiveness of low-dose cardioprotective aspirin
• NSAIDs other than aspirin increase the risk of heart attack, heart failure, and stroke; which can lead to death; the risk is higher if patients consume more than recommended or for longer than necessary
• Use caution in patients with high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, difficulty urinating due to prostate enlargement, or who have had a stroke.
• Patients should tell their healthcare provider if they have symptoms of heart problems or stroke, chest pain, difficulty breathing, weakness in one part or one side of the body, slurred speech, swelling of the legs.
• Pseudoephedrine
• May exacerbate poorly controlled hypertension
• Caution if major cardiovascular risks are present

Pregnancy and lactation

Use ibuprofen with caution /pseudoephedrine during pregnancy in the first 2 trimesters if the benefits outweigh the risks . Animal studies show a risk, and human studies are not available, or studies in animals or humans have not been conducted. Use ibuprofen/pseudoephedrine during the last 3 months of pregnancy in a LIFE-THREAKING EMERGENCY when no safer medications are available. There is positive evidence for the risk of fetal development in humans. Do not take NSAIDs within 3 months before delivery due to the risk of premature closure of the ductus arteriosus.

Ibuprofen/pseudoephedrine is excreted in breast milk. The American Academy of Pediatrics (AAP) states that it is compatible with breastfeeding. Consult your doctor. used literaturehttps://reference.medscape.com/drug/advil-cold-sinus-ibuprofen-pseudoephedrine-999654

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