What are the primary uses of Rapaflo. How should Rapaflo be taken for maximum efficacy. What are the most common side effects of Rapaflo. Are there any precautions to consider when using Rapaflo. How does Rapaflo interact with other medications.

Understanding Rapaflo: A Targeted Treatment for BPH

Rapaflo, also known by its generic name silodosin, is a medication specifically designed to address the symptoms of benign prostatic hyperplasia (BPH) in men. BPH is a common condition characterized by an enlarged prostate gland, which can lead to various urinary symptoms. While Rapaflo does not reduce the size of the prostate, it works by relaxing the muscles in the prostate and bladder, effectively alleviating BPH symptoms.

Key Symptoms Relieved by Rapaflo

• Difficulty initiating urination
• Weak urine stream
• Frequent urination, including nocturia (nighttime urination)
• Urgent need to urinate

Rapaflo belongs to a class of medications known as alpha blockers. It’s important to note that while effective for BPH, Rapaflo is not intended for treating high blood pressure.

Proper Administration of Rapaflo for Optimal Results

To ensure the best possible outcomes when using Rapaflo, it’s crucial to follow the prescribed dosage and administration guidelines. How should Rapaflo be taken? The medication is typically taken orally once daily with a meal, as directed by a healthcare provider.

Alternative Administration Method

For individuals who have difficulty swallowing capsules whole, Rapaflo offers a unique administration option:

1. Sprinkle the entire contents of a capsule onto a small amount (approximately one tablespoon) of cool, soft applesauce.
2. Consume the mixture immediately (within 5 minutes).
3. Do not chew the mixture or save it for later use.
4. Avoid using hot applesauce.
5. Follow each dose with a glass of cool water.

Dosage Considerations

The appropriate dosage of Rapaflo is determined based on individual medical conditions and response to treatment. It’s essential to take the medication regularly and consistently to maximize its benefits. To aid in adherence, consider taking Rapaflo with the same meal each day.

Navigating Potential Side Effects of Rapaflo

As with any medication, Rapaflo may cause side effects in some individuals. What are the most common side effects associated with Rapaflo? The primary side effects reported include:

• Dizziness
• Lightheadedness
• Ejaculation problems

If these effects persist or worsen, it’s important to consult a healthcare provider promptly. To minimize the risk of dizziness and lightheadedness, patients should rise slowly from sitting or lying positions.

Serious Side Effects Requiring Immediate Attention

While rare, some serious side effects may occur. Patients should seek immediate medical attention if they experience:

• Fainting
• Painful or prolonged erections lasting 4 hours or more
• Signs of a severe allergic reaction (rash, itching/swelling, severe dizziness, difficulty breathing)

It’s important to note that this list is not exhaustive, and patients should report any unusual symptoms to their healthcare provider.

Essential Precautions and Considerations for Rapaflo Use

Before initiating treatment with Rapaflo, it’s crucial to inform healthcare providers of any allergies, medical conditions, or medications being taken. Are there specific precautions to consider when using Rapaflo? Indeed, several factors warrant attention:

Medical History Considerations

Patients should disclose their complete medical history, particularly if they have:

• Kidney disease
• Liver disease
• Low blood pressure
• Eye problems (cataracts, glaucoma)

Lifestyle Precautions

Rapaflo may cause dizziness, which can be exacerbated by alcohol or marijuana use. Patients should exercise caution when operating machinery or driving until they understand how the medication affects them. It’s advisable to limit alcohol consumption and consult a healthcare provider regarding marijuana use while taking Rapaflo.

Surgical Considerations

Prior to any surgical procedure, including eye surgeries for cataracts or glaucoma, patients should inform their healthcare providers about their use of Rapaflo. This information is crucial for ensuring safe surgical outcomes.

Rapaflo and Special Populations: Elderly, Pregnant, and Breastfeeding Individuals

The effects of Rapaflo may vary among different population groups. How does Rapaflo impact special populations? Let’s examine the considerations for elderly patients, pregnant individuals, and those who are breastfeeding.

Elderly Patients

Older adults may be more susceptible to certain side effects of Rapaflo, particularly:

• Dizziness
• Orthostatic hypotension (low blood pressure when standing up)

These effects can increase the risk of falls in elderly patients. Healthcare providers may need to adjust dosages or monitoring for this population.

Pregnancy and Breastfeeding

The use of Rapaflo during pregnancy should be approached with caution. It should only be used when clearly necessary, and the potential risks and benefits should be thoroughly discussed with a healthcare provider.

Regarding breastfeeding, it is currently unknown whether Rapaflo passes into breast milk. Nursing mothers should consult their healthcare providers before using this medication.

Understanding Drug Interactions with Rapaflo

Drug interactions can significantly impact the effectiveness and safety of medications. How does Rapaflo interact with other medications? While a comprehensive list of interactions is beyond the scope of this article, it’s crucial to be aware of potential interactions and their implications.

Types of Drug Interactions

Drug interactions with Rapaflo may manifest in several ways:

• Altered effectiveness of Rapaflo
• Increased risk of side effects
• Changes in the effects of other medications

Importance of Full Disclosure

To minimize the risk of adverse interactions, patients should provide their healthcare providers with a complete list of all medications they are taking, including:

• Prescription drugs
• Over-the-counter medications
• Herbal supplements
• Vitamins and minerals

Healthcare providers can then assess potential interactions and adjust treatment plans accordingly.

Monitoring and Follow-up: Ensuring Optimal Outcomes with Rapaflo

Regular monitoring and follow-up are essential components of successful treatment with Rapaflo. How can patients ensure they are achieving optimal results? Consider the following strategies:

Regular Check-ins with Healthcare Providers

Patients should maintain open communication with their healthcare providers throughout their treatment with Rapaflo. This includes:

• Reporting any changes in symptoms, both positive and negative
• Discussing any side effects experienced
• Addressing any concerns or questions about the medication

Monitoring Effectiveness

Patients should track their BPH symptoms to assess the effectiveness of Rapaflo. This may include keeping a log of:

• Frequency of urination
• Urgency of urination
• Strength of urine stream
• Instances of nocturia

If symptoms do not improve or worsen over time, patients should inform their healthcare providers promptly.

Adherence to Treatment Plan

Consistent adherence to the prescribed treatment plan is crucial for achieving optimal results with Rapaflo. Patients should:

• Take the medication as directed, without skipping doses
• Avoid abruptly stopping the medication without consulting a healthcare provider
• Follow any additional recommendations provided by their healthcare team

By maintaining open communication, monitoring symptoms, and adhering to the treatment plan, patients can maximize the benefits of Rapaflo while minimizing potential risks.

Rapaflo Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Silodosin is used by men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It does not shrink the prostate, but it works by relaxing the muscles in the prostate and the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate often or urgently (including during the middle of the night).Silodosin belongs to a class of drugs known as alpha blockers.Do not use this medication to treat high blood pressure.

How to use Rapaflo

Take this medication by mouth as directed by your doctor, usually once daily with a meal.

If you have difficulty swallowing this medication whole, you may sprinkle the entire contents of a capsule on a small amount (such as a tablespoon) of cool soft applesauce just before taking. Swallow the mixture right away (within 5 minutes). Do not chew the mixture, and do not save it for future use. Do not use hot applesauce. Drink a glass of cool water after each dose.

Silodosin may cause a sudden drop in your blood pressure, which could lead to dizziness or fainting. This risk is higher when you first start taking this drug, after your doctor increases your dose, or if you restart treatment after you stop taking it. During these times, avoid situations where you may be injured if you faint.

To avoid injury from dizziness or fainting, your doctor may tell you to take your first dose of silodosin with food at bedtime so that your body can get used to its effects.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly to get the most benefit from it. To help you remember, take it with the same meal each day.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Dizziness, lightheadedness, or ejaculation problems may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting.

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking silodosin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, low blood pressure, certain eye problems (cataracts, glaucoma).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist if you are taking or have ever taken this medication, and about all the other products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and low blood pressure when getting up from a sitting or lying position. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: other alpha blocker drugs (such as prazosin, terazosin).

If you are also taking a drug to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may need to adjust your medications to minimize this risk.

Other medications can affect the removal of silodosin from your body, which may affect how silodosin works. Examples include azole antifungals (such as itraconazole, ketoconazole), clarithromycin, cobicistat, cyclosporine, HIV protease inhibitors (such as lopinavir), mifepristone, ribociclib, ritonavir, among others.

Does Rapaflo interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.

Do not share this medication with others.

Lab and/or medical tests (such as prostate exams, blood pressure) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Rapaflo 8 mg capsule

Color: whiteShape: oblongImprint: WATSON 152 8 MG

This medicine is a white, oblong, capsule imprinted with “WATSON 152” and “8 MG”.

Rapaflo 4 mg capsule

Color: whiteShape: oblongImprint: WATSON 151 4 MG

This medicine is a white, oblong, capsule imprinted with “WATSON 152” and “8 MG”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

About RAPAFLO® (silodosin) | Treat Symptoms of BPH

About RAPAFLO® (silodosin) | Treat Symptoms of BPH

RAPAFLO^® relieves both your
obstructive and irritative BPH
symptoms.

When it comes to BPH, the choice to
seek medical help is often based on how “bothersome” or “disruptive” BPH symptoms are to your daily life.

Like many patients, you may have suffered with BPH symptoms for weeks, months, or even years before seeking treatment. If you’ve been prescribed or are currently taking RAPAFLO^®, the good news is you have a treatment proven to alleviate a range of BPH symptoms.

OBSTRUCTIVE SYMPTOMS

• Hesitancy and straining (finding it difficult to start urinating)
• Weak stream (a trickle is all that
  flows out)
• Intermittency (stopping and starting while urinating)
• Incomplete emptying, or voiding (feeling your bladder is
  not completely empty)

IRRITATIVE SYMPTOMS

• Frequency (having to go again less than 2 hours after finishing)
• Urgency (having to go “right now”)
• Nocturia (getting up at night to urinate)

Sustained BPH

Symptom Relief

You want relief now. And you want relief to last. In two 12-week clinical studies, many patients taking RAPAFLO^® (vs a placebo) reported that their BPH symptoms continually decreased throughout the 12-week period, beginning in as few as 3 to 4 days. In other words, these patients experienced notable symptom relief within a few days that continued to improve over time.

Patients recorded both their obstructive and irritative symptoms throughout the 12-week study, which yielded a composite score called the International Prostate Symptom Score, or IPSS. In this case, the lower the score, the milder the symptoms. (Our BPH Symptom
Calculator is based on this system.)

SYMPTOM CALCULATOR

A STUDY IN RELIEF

This graph shows how patients taking RAPAFLO^® recorded a greater decrease
in
BPH symptoms over time than did patients taking a placebo.

Combined data from two 12-week, randomized, double-blind, placebo-controlled multicenter studies conducted in 923 patients (466 received RAPAFLO^® and 457 received placebo once daily).

TAKE THE 90-DAY CHALLENGE

In the RAPAFLO^® studies, many patients saw their BPH symptoms improve over 90 days
of therapy. If you’ve been prescribed RAPAFLO^®, challenge yourself to stick with treatment
for 90 days. To make it easier, ask your healthcare provider for a 90-day instead of a 30-day
prescription. *

^*Remember to follow your doctor’s advice when taking medication. Any side effects should be reported to your healthcare provider.

Rapaflo (Oral) – instructions for use, dosage, composition, analogs, side effects / Pillintrip

WARNINGS

Contained as part of PRECAUTIONS Section.

PRECAUTIONS

Orthostatic effects

Postural hypotension, with or without symptoms (Z.,
Dizziness) may develop at the start of treatment with RAPAFLO. Like others
alpha blocker, there is a potential for syncope. Patients should be warned
about driving, operating machinery or performing dangerous tasks, if
Start therapy.

Renal failure

Plasma concentrations in a clinical pharmacological study
(AUC and Cmax) of silodosin were approximately three times higher in subjects
with moderate renal insufficiency compared with subjects with normal renal insufficiency
function while the half-life of silodosin doubles in duration. Dose
RAPAFLO should be reduced to 4 mg in patients with moderate renal impairment.
Be careful and monitor these patients for adverse events.

RAPAFLO is contraindicated in patients with severe renal insufficiency
Impairment.

Liver failure

RAPAFLO has not been used in patients with severe
Therefore, hepatic insufficiency should not be administered to such patients.

Drug-drug interaction

In a drug interaction study, co-administration
Single dose of 8 mg RAPAFLO with 400 mg ketoconazole, strong CYP3A4
inhibitor, causes a 3.8-fold increase in the maximum amount of basilodosin in plasma
Concentrations and 3.2-fold increase in silodosin exposure (D.H. AUC).
Concurrent use of ketoconazole or other strong CYP3A4 inhibitors (Z.,
Therefore, itraconazole, clarithromycin, ritonavir) are contraindicated.

Pharmacodynamic interactions between drugs and drugs

Pharmacodynamic interactions between silodosin and
other alpha blockers have not been identified. However, interactions can be
expected and RAPAFLO should not be used in combination with other
alpha blocker.

Pharmacodynamic interaction case study between
silodosin and antihypertensive agents were not administered. However, patients
in phase 3 clinical trials of concomitant antihypertensive drugs
with RAPAFLO there is no significant increase in incidence
Fainting, dizziness or orthostasis. However, be careful
concomitant use with antihypertensives and patient monitoring for potential
adverse events.

Care should also be taken with alpha-adrenergic blocking
Active substances, including RAPAFLO, are administered together with PDE5 inhibitors.
Alpha-adrenergic blockers and PDE5 inhibitors are vasodilators
low blood pressure. Concomitant use of these two classes of drugs can potentially
Causes symptomatic hypotension.

Prostate cancer

Prostate and BPH carcinoma cause many of the same
Description of the problem. These two diseases often coexist. Therefore, patients thought
to have BPH must be investigated prior to starting therapy with RAPAFLO to rule
from prostate carcinoma.

Intraoperative flexible iris syndrome

Intraoperative flexible iris syndrome observed
during cataract surgery in some patients with or before alpha-1 blockers
processed by alpha-1 blockers. This variant of the small pupil syndrome is
characterized by a combination of flaccid iris that reacts to
intraoperative flushes; progressive intraoperative miosis despite
preoperative dilatation with standard mydratic preparations; and possible fallout
the iris in the direction of the faculgification incisions. Patients are planning a cataract
It should be said that the operation informs your ophthalmologist about what you are taking
RAPAFLO.

Interactions with laboratory tests

No interactions with laboratory tests observed
clinical reviews. RAPAFLO treatment up to 52 weeks had no
significant effect on prostate-specific antigen (PSA).

Preclinical toxicology

Carcinogenesis, mutagenesis, impaired fertility

In a 2-year oral carcinogenicity study in rats
administered doses up to 150 mg/kg/day [approximately 8 times the exposure
recommended maximum human dose (MRHE) based on silodosin aucs], increase
The frequency of tumors of follicular cells in the thyroid gland was observed in male rats.
Doses 150 mg/kg/day. Stimulate silodosin-induced thyroid stimulation
Secretion of hormones (TSH) in male rats as a result of increased metabolism and
decrease in the level of thyroxine in the circulation (T4). These changes are believed to be
specific morphological and functional changes in the rat thyroid gland, including
Hypertrophy, hyperplasia and neoplasia. Silodosin didn’t change TSH or T4
Levels in clinical trials and did not affect thyroid studies
indicated. The relationship to human risk of these thyroid tumors in rats is not
famous.

In a 2-year oral carcinogenicity study in mice
administered doses up to 100 mg/kg/day in men (about nine times greater than MRHE
based on silodosin AUC) and 400 mg/kg/day in women (about 72 times the MRHE
based on AUC) there were no significant tumor findings in male mice. Female
Mice treated with doses of 150 mg/kg/day for 2 years (about 29 times more than MRHE
based on AUC) or higher statistically significant increases in
The incidence of mammary adenoacanthomas and adenocarcinomas. Increase
The incidence of mammary tumors in female mice was considered secondary.
silodosin-induced hyperprolactinemia measured in treated mice. Increase
Prolactin levels have not been observed in clinical studies. Relevance to people
the risk of prolactin-mediated endocrine tumors in mice is unknown. Rats and mice
do not produce glucuronidated silodosin in human serum
about four times the level of circulating silodosin, and this has
pharmacological activity is similar to that of silodosin.

Silodosin showed no signs of mutagens or genotoxicity
Potential in in vitro Ames assay, murine lymphoma assay, unscheduled DNA
synthesis test and in vivo mouse micronucleus test. Weakly positive
The answer was two in vitro Chinese Hamster Tests (CHL) for
chromosome aberration tests at high cytotoxic concentrations.

Treatment of male rats with silodosin for 15 days
resulted in decreased fertility at a high dose of 20 mg/kg/day (approximately twice
MRHE) that was reversible after a two-week recovery period. No effect
observed at 6 mg/kg/day. The clinical relevance of this finding is not
famous.

In a fertility study in female rats, the high dose is 20
mg/kg/day (approximately 1-4 times the MRHE), however, led to changes in the estrus cycle
does not affect fertility. No effect on the estrus cycle was observed at 6
mg/kg/day.

In a male rat fertility study, viability and sperm count
were significantly lower after administration of 600 mg/kg/day (approximately 65 times)
MRHE) for one month. Histopathological examination of sterile men
disclosed changes in the testicles and epididymis at a dose of 200 mg/kg/day (approx.
times MRHE).

Use in certain populations

Pregnancy

Pregnancy category B RAPAFLO not for use in. Woman.

Embryo/fetus study in rabbits showed a decrease
maternal body weight at 200 mg/kg/day (approximately 13-25 times the maximum
recommended human exposure or MRGV of silodosin via AUC). Not statistically
significant teratogenicity was observed at this dose.

Silodosin was not teratogenic when administered
pregnant rats during organogenesis at 1000 mg/kg/day (estimated
about 20 times the MRHE). No maternal or fetal effects were observed
this dose. Rats and rabbits do not produce glucuronidated silodosin, i.e.
present in human serum at about 4 times the circulating level
silodosin, which has pharmacological activity similar to that of silodosin.

Does not affect physical or behavioral development
Offspring were observed in the treatment of rats during pregnancy and lactation
up to 300 mg/kg/day.

Pediatric Use

RAPAFLO is not indicated for use in pediatric patients.
Safety and efficacy in pediatric patients have not been established.

Geriatric use

Double-blind, placebo-controlled, 12-week clinical trial
RAPAFLO studies, 259(55.6%) were under 65, 207 (44.4%)
patients were 65 years of age or older, while 60 (12.9%) patients were 75 years of age
age and older. Orthostatic hypotension was noted in 2. 3% of RAPAFLO
Patients <65 years (1.2% for placebo), 2.9% of RAPAFLO patients ≥ 65 years (1.9% for placebo) and 5.0% of patients and gr; 75 Age (0% for placebo). Otherwise, there were no significant differences in safety or efficacy between older and younger patients.

Renal failure

Effect of renal dysfunction on silodosin
Pharmacokinetics was included in a single dose study in six male patients.
moderate renal failure and seven male subjects with normal renal function.
Plasma concentrations of silodosin were about three times higher
Subjects with moderate renal impairment compared to subjects with normal
Kidney function.

RAPAFLO should be reduced to 4 mg daily in patients
with moderate renal failure. Be careful and keep an eye on patients
adverse events.

RAPAFLO has not been used in patients with severe
Renal failure. RAPAFLO is contraindicated in patients with severe renal insufficiency.
Impairment.

Liver failure

Study compared nine moderately severe male patients
liver dysfunction (Child-Pugh scores of 7 to 9) in nine healthy men
single dose pharmacokinetics of silodosin did not change significantly
Patients with liver dysfunction. Dose adjustment is not required in patients
with mild or moderate liver dysfunction.

RAPAFLO has not been used in patients with severe
liver dysfunction. RAPAFLO is contraindicated in patients with severe liver disease
Impairment.

Silodosin: Side Effects, Dosage, Uses & More

Contents

• Blackout and dizziness warning: This medicine may cause low blood pressure when you stand up after sitting or lying down, which can lead to dizziness and fainting. Don’t drive, drive cars, or take on dangerous tasks until you know how it affects you.
• Cataract surgery warning: This medicine may affect your pupils during cataract surgery. A complication known as intraoperative iris floppy syndrome (IFIS) has occurred in some people who have taken or have recently taken this type of medication.

Silodosin is a prescription drug. It comes in the form of an oral capsule.

Silodosin oral capsules are available as a protected Rapaflo formulation. It is also available as a generic drug. Generics usually cost less than branded versions. In some cases, they may not be available in all strengths or forms as brand name medicines.

Silodosin can be used in combination therapy. This means that you need to take it with other medicines.

Why it is used

Silodosin is used to treat symptoms of benign prostatic hyperplasia (BPH) in adult men. This condition is also called an enlarged prostate. It helps reduce the symptoms of BPH and improve the ability to urinate.

When the prostate becomes enlarged, it can squeeze or compress the urethra and affect your ability to urinate. This can cause:

• nocturia
• sudden urge to urinate
• frequent urination
• difficulty starting to urinate
• feeling that you cannot empty your bladder completely
• poor urine flow
• straining during urination
• dripping after urination 90 111

How it works

This medicine belongs to a class of drugs called alpha-1 blockers. A drug class is a group of drugs that work in a similar way. These drugs are often used to treat these conditions.

Alpha-1 receptors are located in the prostate and bladder. They are responsible for the contraction of the smooth muscles of the bladder and prostate gland. Silodosin blocks these receptors, causing relaxation of the smooth muscles of the prostate and bladder. This will reduce your BPH symptoms and improve your ability to urinate.

Silodosin side effects

Silodosin oral capsules do not cause drowsiness, but may cause other side effects.

More common side effects

Common side effects that may occur with silodosin include:

• dizziness
• diarrhea
• orthostatic hypotension (low blood pressure when standing up after sitting or lying down)
• headache
• retrograde ejaculation (occurs when semen enters the bladder and not outside the penis)
• cold
• Stuffy nose

Mild side effects may disappear within a few days or a few weeks. Talk to your doctor or pharmacist if they are difficult or do not go away.

Serious side effects

Call your doctor if you have serious side effects. Call 911 if your symptoms seem life-threatening or if you think you need emergency medical attention. Serious side effects and their symptoms may include the following:

• Allergic reaction (hypersensitivity to drugs). Symptoms may include:
  • swelling of the face, lips, tongue, or throat
  • trouble breathing or swallowing
  • skin rash
  • itching
  • stinging
  • blisters on the skin or in the mouth, nose, or eyes 901 11
  • peeling of the skin
  • fainting or dizziness
  • very fast heart rate
• Liver problems. Symptoms may include:
  • yellowing of the skin or whiteness of the eyes
  • nausea
  • vomiting
  • loss of appetite
  • abdominal pain and swelling
  • slight bruising
  • pale stool color 90 111
  • dark urine
  • unusual or unexplained fatigue
• Prolonged erection ( priapism). This is an erection that lasts more than four hours.
• Sudden drop in blood pressure, especially when you get up after sitting or lying down. Symptoms may include:
  • dizzy
  • feeling headless
  • unconsciousness

Disclaimer: Our goal is to provide you with the most current and up-to-date information. But because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information does not replace medical advice. Always discuss possible side effects with a doctor who knows your medical history.

Silodosin may interact with other medicines.

Silodosin Oral Capsule may interact with other medicines, vitamins, or herbs you are taking. An interaction is when a substance changes the way a drug works. It can be harmful or prevent the medicine from working well.

To avoid interactions, your doctor must carefully administer all of your medicines. Tell your doctor about any medications, vitamins, or herbs you are taking. To find out how this medicine may interact with other medicines you are taking, talk to your doctor or pharmacist.

Examples of drugs that may interact with silodosin are listed below.

antifungals

Taking these medicines with silodosin may increase the levels of silodosin in the body. Do not take these medicines with silodosin:

• itraconazole
• ketoconazole

Blood pressure medicines

Taking calcium channel blockers with silodosin can increase the level of silodosin in the body. Examples of such drugs include:

• diltiazem
• verapamil

Antibiotics

Taking clarithromycin with silodosin increases the level of silodosin in the body. Do not take this medicine with silodosin.

Taking erythromycin with silodosin may increase the level of silodosin in the body and increase the risk of side effects.

HIV medicines

These drugs are in a class of drugs called protease inhibitors. Taking these medicines with silodosin may increase the levels of silodosin in the body. Examples of such drugs include:

• atazanavir
• danmavir
• fosamprenavir
• indinavir
• nelfinavir
• saquinavir

900 04 Taking ritonavir with silodosin increases the level of silodosin in the body. Do not take this medicine with silodosin.

Immune suppressant

Taking ciclosporin with silodosin may increase the level of silodosin in the body. These drugs are not recommended.

Other drugs used to treat benign prostatic hyperplasia (BPH)

These medicines can make your blood pressure too low if you take them with silodosin. They can also increase your risk of orthostatic hypotension, which is a sudden drop in blood pressure when you stand up after sitting or lying down. This condition can cause dizziness or fainting.

Examples of such drugs include:

• alfuzosin
• doxazosin
• prazosin
• terazosin
• tamsulosin

Blood pressure medicines

These medicines can make your blood pressure too low if you take them with silodosin. They can also increase your risk of orthostatic hypotension, which is a sudden drop in blood pressure when you stand up after sitting or lying down. This condition can cause dizziness or fainting.

Examples of such drugs include:

• metoprolol
• carvedilol
• atenolol
• lisinopril
• losartan
• valsartan
• amlodipine
• clonidine

9 0002 Erectile dysfunction medicines

These medicines can make your blood pressure too low if you take them with silodosin. They can also increase your risk of orthostatic hypotension, which is a sudden drop in blood pressure when you stand up after sitting or lying down. This condition can cause dizziness or fainting.

Examples of such drugs include:

• avanafil
• Sildenafil
• tadalafil
• Vardenafil

Disclaimer: Our goal is to provide you with the most current and up-to-date information. However, because drugs affect each person differently, we cannot guarantee that these data include all possible interactions. This information does not replace medical advice. Always talk to your doctor about potential interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter medications you are taking.

Silodosin warnings

This medicine comes with a few caveats.

Allergy Warning

This medicine may cause a severe allergic reaction. Symptoms may include:

• trouble breathing
• swelling of the throat or tongue
• Osip
• itching
• Osip

Call 911 or call the nearest ambulance if you develop these symptoms.

Do not take this medicine again if you have ever had an allergic reaction to it. Repeated use may be lethal (lead to death).

Grapefruit Warning

Drinking grapefruit juice while taking silodosin may increase your levels of silodosin and increase side effects. Talk to your doctor about whether grapefruit products are safe for you.

Alcohol Interaction Warning

Silodosin may make you dizzy. Drinking alcohol can also cause dizziness and drowsiness. You should limit the amount of alcohol you drink.

Warnings for people with certain medical conditions

For people with kidney disease: Your body gets rid of this medicine partly through your kidneys. If your kidneys are not working well, more of the medicine may remain in your system. This increases the risk of side effects. This medicine is not recommended if you have severe kidney disease. If you have moderate kidney disease, your doctor may prescribe a lower dose for you.

For people with liver problems: This medicine treats your liver. If your liver is not working well, more of the medicine may remain in your body. This increases the risk of side effects. This medicine is not recommended if you have severe liver disease as it has not been studied in people with this condition.

For people with low blood pressure (hypotension): This medicine can cause low blood pressure when you get up after sitting or lying down, dizziness, and even lowering your blood pressure. Don’t drive, drive cars, or take on dangerous tasks until you know how it affects you.

Warnings for other groups

For pregnant women: This medicine is used to treat BPH in men. Not intended for use in women.

This medicine is a Category B medicine for use during pregnancy. This means two things:

For breastfeeding women: This medicine is used to treat BPH in men. Not intended for use in women. It is not known if this drug is excreted in breast milk.

For older people: If you are 65 years of age or older, you may be at higher risk of low blood pressure when you stand up from a sitting or lying position (orthostatic hypotension).

For children: It is not known if this medicine is safe and effective in children under 18 years of age.

How to take Silodosin

Not all possible dosages and regimens are included here. Your dose, form and frequency of administration will depend on:

• your age
• the condition being treated
• severity of your condition
• other health conditions you have
• how you respond to your first dose

Medications and strengths

Generic: Silodosin capsule

Brand: Rapaflo

• Form: oral capsule
• Strengths: 4 mg and 8 mg

Dosage for benign prostatic hyperplasia

Adult Dose (18-64 years)

A typical dose is 8 mg once daily with food.

Pediatric Dose (ages 0-17 years)

The safety and efficacy of silodosin in children under 18 years of age have not been established.

Higher dose (age 65 and older)

As you age, your organs (such as your liver or kidneys) may stop working. Your body may process this medicine more slowly. Too many drugs in the body can lead to additional side effects. Based on good liver and kidney function, your doctor may decide to adjust your dosage or not prescribe this medication at all.

Special dosage recommendations

For people with kidney disease: The dosage of silodosin depends on the function of the kidneys.

• Severe kidney disease: Silodosin is not recommended.
• Moderate kidney disease: The recommended dose is 4 mg once daily with food.

Disclaimer: Our goal is to provide you with the most current and up-to-date information. But because drugs affect each person differently, we cannot guarantee that this list includes all possible doses. This information does not replace medical advice. Always talk to your doctor or pharmacist about the doses that are right for you.

Take as directed

Silodosin is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all or don’t stop: If you don’t take or stop taking this medicine, your symptoms of BPH may get worse. If you stop or forget to take this medicine for a few days, talk to your doctor before starting again.

If you take too much: You may get low blood pressure, especially if you get up after sitting or lying down. Symptoms may include:

• dizziness or weakness
• unconsciousness
• weakness
• blurred vision
• confusion

Call your doctor or get help to the American Association of Poison Control Centers at 1- 800-222-1222 or online toolBut if you have severe symptoms, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take it as soon as possible. However, if your next dose is only a few hours away, skip the missed dose. Never try to compensate for taking two capsules at the same time. This can lead to dangerous side effects.

How to tell if a medicine is working: Your symptoms of BPH should improve. You may find it easier to urinate.

Keep this in mind if your doctor prescribes silodosin.

Basic information

• This medicine should be taken with food.
• Taking this medicine on an empty stomach may increase the risk of side effects such as a drop in blood pressure when you get up after sitting or lying down.
• Take this medicine at the same time each day. This may help reduce side effects.
• If you have trouble swallowing capsules, you can carefully open the capsule and sprinkle the powder in it with a tablespoon of applesauce. Swallow applesauce within five minutes without chewing. Drink an 8-inch glass of cold water to make sure you swallow the powder completely. Applesauce should not be hot and soft enough to be swallowed without chewing. Do not store this applesauce powder mixture for future use.

Warehouse

• Store Silodosin at 59°C to 86°F (15°C to 30°C).
• Keep this medicine away from light.
• Do not store this medicine in damp or damp places such as bathrooms.

tapping

The prescription for this medicine can be refilled. You do not need a new prescription to refill this medicine. Your doctor will write the number of refills on your prescription.

Travel

When traveling with medication:

• Always carry your medication with you. Never put it in your checked bag while flying. Keep it in your bag.
• Don’t worry about air devices at the airport. I can’t hurt drugs.
• You may need to show airport staff the pharmacy sticker for your medications. Always carry the original prescription container with you.
• Do not put this medicine in the glove compartment of your car or leave it in your car. Be sure to avoid this when the weather is very hot or very cold.

Clinical follow-up

During treatment with silodosin, your doctor may perform certain tests. These tests may include:

• Prostate specific blood test: The symptoms of BPH and prostate cancer may be similar. Your doctor may do a prostate exam and a blood test called prostate specific antigen (PSA) to make sure you don’t have prostate cancer before prescribing medication.
• Blood pressure check: Your doctor can check if your blood pressure is low. If you have low blood pressure (hypotension), taking this medicine may lower your blood pressure even more, and it may not be safe for you to take it.

Your diet

To reduce the symptoms of BPH, your doctor may recommend that you limit the amount of fluid you drink at night. I can also recommend that you reduce the amount of alcohol and caffeine you drink.

availability

Not every pharmacy stocks this medicine. When filling out a prescription, be sure to call ahead to make sure your pharmacies have it.

Pre-approval

Many insurance companies require pre-approval for this drug. This means that your doctor will need to get insurance company approval before your insurance company will pay for the prescription.

There are other medicines available to treat your condition. Some may suit you better than others. Talk to your doctor about other treatment options that may help you.