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Reaction to benzoyl peroxide: Benzoyl Peroxide (Topical Route) Precautions

Side effects of benzoyl peroxide

Like all medicines, benzoyl peroxide can cause side effects, although not everyone gets them.

Common side effects

These common side effects of benzoyl peroxide happen in more than 1 in 10 people. There are things you can do to help cope with them:

Dry skin

Apply a moisturiser and lip balm regularly. The best type of moisturiser is an oil-free face moisturiser for sensitive skin. Try to take shorter showers, using warm water rather than hot.

Peeling or red skin

Redness may be less obvious on brown or black skin. Try using the gel or wash less often, or stop using it for a few days until the irritation goes away, then start again. Do not use other products on your skin until it gets better.

Speak to a doctor if your symptoms do not get better or are severe.

Burning or stinging (skin irritation)

Try using the gel or wash less often (once a day instead of twice, or every other day). It might help to stop using the gel for a few days until the irritation goes away, then start again.

If the irritation does not go away after this time, stop using it and speak to a doctor.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Stop using benzoyl peroxide if:

  • the skin that you’re treating becomes swollen
  • you get blisters on your skin

If your symptoms do not get better within a couple of days or if they get worse at any time, call a doctor or call 111 straight away.

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to benzoyl peroxide.

Immediate action required: Call 999 now if:

  • your lips, mouth, throat or tongue suddenly become swollen
  • you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • your throat feels tight or you’re struggling to swallow
  • your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • you suddenly become very confused, drowsy or dizzy
  • someone faints and cannot be woken up
  • a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Other side effects

These are not all the side effects of benzoyl peroxide. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 30 September 2022

Next review due: 30 September 2025

Benzoyl Peroxide Topical (Acne Treatment)

Brand Names:Acne-10, Acne-Clear, Acne Foaming Cream Face Cleanser, Acne Treatment, Ben-Aqua, Benoxyl 10

Reviewed:

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect, which allows excess oils and dirt to be easily washed away from the skin.

Benzoyl peroxide topical (for the skin) is used to treat acne.

There are many brands and forms of benzoyl peroxide available. Not all brands are listed on this leaflet.

Benzoyl peroxide topical may also be used for purposes not listed in this medication guide.

uses

What is Benzoyl Peroxide Topical (Acne Treatment) used for?

  • Acne

warnings

What is the most important information I should know about Benzoyl Peroxide Topical (Acne Treatment)?

You should not use benzoyl peroxide if you are allergic to it, or if you have:

  • very sensitive skin.

Ask a doctor or pharmacist if this medicine is safe to use if you have any skin conditions or allergies.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not use this medicine on a child without medical advice.

Side Effects

What are the side effects of Benzoyl Peroxide Topical (Acne Treatment)?

Benzoyl peroxide topical can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using benzoyl peroxide and call your doctor at once if you have any of these side effects on the treated skin:

  • severe itching or burning;
  • severe stinging or redness;
  • swelling; or
  • peeling.

Common side effects may include:

  • mild stinging or burning;
  • itching or tingly feeling;
  • skin dryness, peeling, or flaking; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Benzoyl Peroxide Topical (Acne Treatment) if I’m pregnant or breastfeeding?

C

Risk cannot be ruled out

Based on FDA pregnancy categories

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Interactions

What drugs and food should I avoid while taking Benzoyl Peroxide Topical (Acne Treatment)?

Rinse with water if this medicine gets in your eyes or mouth.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid exposure to sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Dosage Guidelines & Tips

How to take Benzoyl Peroxide Topical (Acne Treatment)?

Use Benzoyl Peroxide Topical (Acne Treatment) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Benzoyl Peroxide Topical (Acne Treatment)?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

Overdose Signs

What happens if I overdose on Benzoyl Peroxide Topical (Acne Treatment)?

If you think you or someone else may have overdosed on: Benzoyl Peroxide Topical (Acne Treatment),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Benzoyl Peroxide Topical (Acne Treatment), call 911

911

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Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health. 

ICSC 0225 – BENZOYL PEROXIDE

ICSC 0225 – BENZOYL PEROXIDE

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Chinese – ZHEnglish – ENFinnish – FIFrench – FRGerman – DEHebrew – HEHungarian – HUItalian – ITJapanese – JAKorean – KOPersian – FAPolish – PLPortuguese – PTRussian – RUSpanish – ES

BENZOYL PEROXIDE ICSC: 0225 (April 2002)


CAS #: 94-36-0
UN#: 3104
EINECS #: 202-327-6

SPECIAL HAZARDS PREVENTIVE MEASURES FIRE EXTINGUISHING
FIRE AND EXPLOSION Many reactions can lead to fire or explosion. Risk of fire or explosion. Explosive. See Chemical Hazards. DO NOT use open flames, DO NOT spark, DO NOT SMOK. NO contact with flammable substances. DO NOT allow contact with hot surfaces. DO NOT subject to friction or shock. Use a hand tool that does not generate sparks. Use plenty of water. In case of fire: cool drums, etc. spraying water. Fight fire from cover.

PREVENT DUST!
SYMPTOMS PREVENTIVE MEASURES FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or respiratory protection. Fresh air, peace.
Leather Redness. Protective gloves. Protective clothing. Remove contaminated clothing. Rinse and then wash skin with soap and water.
Eyes Redness. Wear protective goggles. First of all, rinse with plenty of water for several minutes (remove contact lenses if possible without difficulty), then seek medical advice.
Ingestion Do not eat, drink or smoke while working. Rinse your mouth. Give one or two glasses of water to drink. Seek medical attention.

LEAK DISPOSAL CLASSIFICATION AND LABELING
Leave the danger area! Remove all sources of ignition. Wash off the residue with plenty of water. DO NOT cover with sawdust or other combustible absorbents.

According to UN GHS criteria

Transport
UN classification
UN hazard class: 5. 2; UN Packing Group: II

STORAGE
Ensure fire resistance. Separated from combustible substances and reducing agents. Store only in original packaging. See chemical hazards.
PACKAGING
BENZOYL PEROXIDE ICSC: 0225
PHYSICAL AND CHEMICAL PROPERTIES

Physical Condition; Appearance

WHITE CRYSTALLINE OR POWDER.

Physical hazards

Chemical

May decompose very violently on impact, friction or concussion. May explode if heated above 103-105°C. On combustion, forms irritating and toxic gases or benzoic acid (see ICSC 0103) and carbon monoxide (see ICSC 0023). The substance is a strong oxidizing agent. Actively reacts with combustible materials and reducing agents. Reacts violently with many organic acids, inorganic acids, alcohols and amines. Gives a fire and explosion hazard.

Formula: C 1 4 H 1 0 O 4
Molecular weight: 242.2

Decomposes at 103-105°C
Density: 1.3 g/cm³
Solubility in water: slightly soluble
Vapor pressure, kPa at 20°C: Autoignition temperature : 80°C
Octanol-water partition coefficient (Log Pow): 3.46

BODY AND EXPOSURE EFFECTS

Routes of exposure

The substance can be absorbed into the body by inhalation of the substance in aerosol form.

Short term effects

The substance is irritating to the eyes, skin and respiratory tract.

Inhalation risk

Evaporation at 20°C negligible; however, dangerous concentrations of airborne particles can be reached quickly when dispersed, especially in powdered form.

Effects of prolonged or repeated exposure

Repeated or prolonged contact may cause skin sensitization.

Maximum Permissible Concentrations
TLV: 5 mg/m 3 as TWA; A4 (not classified as a human carcinogen).
MAC: 5 mg/m 3 ; Peak Exposure Limitation Category: I(1)

ENVIRONMENT

NOTES
Carrier solvents used in commercial formulations may alter physical and toxicological properties.
Wash contaminated clothing with plenty of water as there is a risk of fire.

ADDITIONAL INFORMATION

EC classification
Symbol: E, Xi; R: 2-36-43; S: (1/2)-3/7-14-36/37/39

(en) Neither the ILO nor the WHO nor the European Union accept any responsibility for the quality and accuracy of the translation or for the possible use of this information.
© Russian version, 2018

What can benzoyl peroxide do in cosmetics? Beauty educational program per minute

Contents:

  1. Benzoyl peroxide: action
  2. Properties of benzoyl peroxide
  3. Indications for use
  4. Precautions
  5. Application of Benzoyl Peroxide
  6. Benzoyl peroxide side effects

Upon contact with the skin, benzoyl peroxide decomposes into benzoic acid and oxygen. Benzoic acid stimulates the process of cell renewal, due to which keratinized scales are removed from the surface of the epidermis, which prevent the proper secretion of sebum.

The basis of the effectiveness of this substance against acne is the destruction of Propionibacterium acnes bacteria, which, as you might guess from the name, provoke rashes on the skin. And it is oxygen that kills them – one of the decomposition products of benzoyl peroxide.

The healing properties of benzoyl peroxide are due to its strong antibacterial action: it inhibits the growth of P. Acnes bacteria and exfoliates the upper layer of the epidermis, preventing the accumulation of fat and dirt in the pores.

With prolonged use, cosmetics with benzoyl peroxide can greatly reduce the number of rashes and prevent the appearance of new ones, and at the same time even out skin tone and relief.

Indications for the use of benzoyl peroxide – acne, seborrhea, excessive sebum secretion, characteristic of oily and combination skin. As a rule, cosmetologists and dermatologists prescribe cosmetic preparations containing this component for people with mild to moderate acne.

Since cosmetics, which include benzoyl peroxide, are freely sold in any Russian pharmacy, many people prescribe it to themselves as a measure to combat rashes.

It is better not to self-medicate – first consult a dermatologist or cosmetologist.

Despite the fact that only cosmetic products with a conditionally safe percentage of benzoyl peroxide are in free circulation in the Russian Federation, it is still worth following some recommendations.

1. Although benzoyl peroxide is not prohibited during pregnancy, it should be used with caution. Dermatologists insist: when pregnancy occurs, the dose should be reduced and such cosmetic products should be applied only pointwise.

2. Like all exfoliating ingredients, benzoyl peroxide increases the skin’s photosensitivity to UVA and UVB rays. When applying cosmetics with this component, protect your skin from the sun with an SPF cream.

3. Many people who have experienced the use of benzoyl peroxide report dry, irritated skin. And it’s true: benzoyl peroxide mercilessly dries the skin, and in combination with salicylic acid, which is effective against acne, it can even turn it into a state of parchment.

But this is exactly the case when beauty requires sacrifice: a period that is unpleasant for the skin can only be endured, the main thing is to intensely moisturize and nourish the skin, and also do not forget about protection from the sun.

4. When using cosmetics with benzoyl peroxide, add a good nourishing cream to your skin care routine, as this substance destroys the hydrolipidic mantle of the skin, which needs to be restored and strengthened.

Apply cosmetics with benzoyl peroxide once a day is sufficient. This should be done in the evening on dry, cleansed skin, avoiding the area around the eyes. The most effective will be the use of the course – for an obvious and lasting result, three months of use will be enough.