What are the uses of Selsun Blue for skin conditions. How does selenium sulfide work in treating dandruff and seborrheic dermatitis. What are the proper application methods for Selsun Blue. How effective is Selsun Blue in treating tinea versicolor. What are the potential side effects of using Selsun Blue. Are there any precautions to consider when using Selsun Blue. How does Selsun Blue interact with other medications.

Understanding Selsun Blue and Its Active Ingredient

Selsun Blue is a widely recognized brand of medicated shampoo primarily used to treat various scalp conditions. The active ingredient in Selsun Blue is selenium sulfide, which belongs to a class of medications known as anti-infectives. This powerful compound works by slowing down the growth of yeast and fungi that cause certain skin and scalp issues.

But how exactly does selenium sulfide combat these pesky microorganisms? The mechanism of action involves disrupting the cell membranes of fungi and yeasts, ultimately leading to their demise. This process helps alleviate symptoms associated with conditions like dandruff, seborrheic dermatitis, and tinea versicolor.

The Science Behind Selenium Sulfide

Selenium sulfide’s effectiveness lies in its ability to:

• Reduce the production of oleic acid, a substance that can irritate the scalp
• Slow down skin cell turnover, which helps prevent excessive flaking
• Inhibit the growth of Malassezia, a type of yeast commonly associated with dandruff and seborrheic dermatitis
• Possess antifungal properties that combat the fungus responsible for tinea versicolor

Primary Uses of Selsun Blue in Dermatology

While Selsun Blue is commonly associated with dandruff treatment, its applications extend beyond just flaky scalps. The medication has proven effective in addressing several dermatological concerns. What are the main conditions that Selsun Blue can help treat?

Dandruff and Seborrheic Dermatitis

Dandruff, characterized by flaking of the scalp, is perhaps the most well-known use of Selsun Blue. Seborrheic dermatitis, a more severe form of dandruff, also responds well to this medication. The selenium sulfide in Selsun Blue helps reduce itching, flaking, irritation, and redness associated with these conditions.

Tinea Versicolor

Tinea versicolor is a fungal infection that causes discolored patches on the skin. Selsun Blue has shown efficacy in treating this condition when applied directly to affected areas. The antifungal properties of selenium sulfide work to eliminate the yeast responsible for tinea versicolor, helping restore normal skin pigmentation.

Proper Application Methods for Maximum Effectiveness

To achieve optimal results with Selsun Blue, it’s crucial to follow the correct application methods. How should one use this medication for different skin conditions?

For Dandruff and Seborrheic Dermatitis

1. Wet the scalp thoroughly
2. Apply the shampoo and massage it into the scalp
3. Leave on for 2-3 minutes
4. Rinse thoroughly
5. Repeat if necessary (check product instructions)
6. Use 1-2 times per week or as directed by a healthcare professional

For Tinea Versicolor

1. Apply selenium sulfide to affected skin areas
2. Lather with a small amount of water
3. Leave on for 10 minutes
4. Rinse thoroughly
5. Apply once daily for 7 days or as directed by a doctor

Is shaking the product necessary before use? Some brands of Selsun Blue require shaking before application. Always check the product package for specific instructions.

Potential Side Effects and Precautions

While Selsun Blue is generally well-tolerated, it’s essential to be aware of potential side effects and take necessary precautions. What are the most common side effects associated with using Selsun Blue?

Common Side Effects

• Skin irritation
• Dry skin
• Oily or dry hair/scalp
• Temporary hair loss
• Hair discoloration (can be minimized by thorough rinsing)

If these side effects persist or worsen, it’s advisable to discontinue use and consult a healthcare professional. In rare cases, serious allergic reactions may occur. Seek immediate medical attention if you experience symptoms such as rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

Important Precautions

Before using Selsun Blue, consider the following precautions:

• Inform your doctor of any allergies or sensitivities
• Avoid use on broken or irritated skin
• Not recommended for children under 2 years old
• Use with caution during pregnancy (consult a doctor)
• Avoid contact with eyes, nose, mouth, and genital areas
• Remove jewelry before application to prevent damage

Selsun Blue and Drug Interactions

When using any medication, it’s crucial to be aware of potential drug interactions. Can Selsun Blue interact with other medications? While selenium sulfide is primarily used topically, which limits systemic absorption, it’s still important to inform your healthcare provider about all medications you’re currently taking.

Some potential interactions to be mindful of include:

• Other topical medications applied to the same area
• Systemic antifungal medications
• Certain hair care products that may interact with selenium sulfide

To ensure safety and effectiveness, always consult with a healthcare professional or pharmacist about potential drug interactions before using Selsun Blue alongside other medications or products.

Exploring Selsun Blue’s Potential for Vitiligo Treatment

While Selsun Blue is not primarily marketed for vitiligo treatment, there has been some interest in its potential benefits for this condition. Vitiligo is a skin disorder characterized by the loss of skin pigment, resulting in white patches on various parts of the body. Can Selsun Blue offer any relief for vitiligo sufferers?

The Selenium Connection

Selenium, the key component in Selsun Blue, has been studied for its potential role in skin health and pigmentation. Some research suggests that selenium deficiency might be associated with vitiligo progression. While this doesn’t necessarily mean that topical application of selenium sulfide can treat vitiligo, it has sparked interest in exploring its potential benefits.

Anecdotal Evidence and Research

There have been anecdotal reports of individuals experiencing some repigmentation after using Selsun Blue on vitiligo-affected areas. However, it’s important to note that these claims are not backed by substantial scientific evidence. Rigorous clinical trials are needed to establish the efficacy and safety of using Selsun Blue for vitiligo treatment.

If you’re considering using Selsun Blue for vitiligo, it’s crucial to consult with a dermatologist first. They can provide personalized advice and discuss more established treatment options for vitiligo management.

Comparing Selsun Blue to Other Dandruff Treatments

With numerous anti-dandruff products available on the market, how does Selsun Blue stack up against its competitors? Let’s explore some comparisons to help you make an informed decision about your scalp care routine.

Selsun Blue vs. Head & Shoulders

• Active Ingredient: Selsun Blue uses selenium sulfide, while Head & Shoulders primarily uses zinc pyrithione
• Mechanism: Both target the Malassezia yeast, but through different pathways
• Strength: Selsun Blue is often considered more potent for severe dandruff cases
• Frequency of Use: Selsun Blue is typically used less frequently (1-2 times per week) compared to daily use for Head & Shoulders

Selsun Blue vs. Nizoral

• Active Ingredient: Nizoral contains ketoconazole, an antifungal agent
• Prescription Status: Nizoral is available in both over-the-counter and prescription strengths, while Selsun Blue is primarily OTC
• Range of Use: Nizoral is also effective against a wider range of fungal infections
• Frequency: Both are typically used 1-2 times per week for maintenance

Selsun Blue vs. T/Gel

• Active Ingredient: T/Gel uses coal tar as its primary active ingredient
• Targeting: T/Gel is particularly effective for psoriasis and seborrheic dermatitis, while Selsun Blue excels in dandruff control
• Scent: T/Gel has a distinct coal tar odor, which some users find less pleasant compared to Selsun Blue
• Staining: Coal tar in T/Gel may stain light-colored hair or fabrics, a concern not typically associated with Selsun Blue

Tips for Maximizing Selsun Blue’s Effectiveness

To get the most out of your Selsun Blue treatment, consider implementing these tips and best practices:

For Scalp Treatments

1. Start with a thorough scalp massage: This helps distribute the product evenly and increases blood flow to the scalp
2. Use lukewarm water: Extremely hot water can irritate the scalp and exacerbate dandruff
3. Leave on for the recommended time: Resist the urge to rinse too quickly; allow the active ingredients to work
4. Rinse thoroughly: Ensure all product is removed to prevent build-up and potential irritation
5. Alternate with a gentle shampoo: This can help maintain scalp health between medicated washes
6. Be consistent: Regular use as directed is key to seeing improvements

For Tinea Versicolor Treatment

1. Cleanse the affected area before application: This ensures better contact between the medication and the skin
2. Apply to dry skin: This can help the product adhere better to the affected areas
3. Use a timer: Ensure you’re leaving the product on for the full recommended 10 minutes
4. Pat dry after rinsing: Avoid rubbing, which can irritate the skin
5. Wash clothes and bedding regularly: This helps prevent reinfection

By following these guidelines, you can enhance the effectiveness of Selsun Blue and potentially see faster results in managing your skin or scalp condition.

Long-term Use and Maintenance with Selsun Blue

For many individuals, conditions like dandruff and seborrheic dermatitis are chronic issues that require ongoing management. How should Selsun Blue be incorporated into a long-term skin and scalp care routine?

Establishing a Maintenance Routine

Once you’ve achieved control over your symptoms, it’s important to develop a maintenance plan to prevent recurrence. This typically involves:

• Reducing the frequency of Selsun Blue use (e.g., once a week or every other week)
• Alternating with a gentle, non-medicated shampoo
• Monitoring your scalp condition and adjusting usage as needed
• Incorporating other scalp-healthy practices, such as proper nutrition and stress management

When to Consult a Healthcare Professional

While Selsun Blue can be effective for long-term management, there are instances where professional medical advice is necessary:

• If symptoms persist or worsen despite regular use
• If you experience new or unusual side effects
• If you’re using Selsun Blue for an extended period without improvement
• If you’re considering using it for conditions not listed on the product label (e.g., vitiligo)

Remember, a dermatologist can provide personalized advice and may recommend alternative treatments or combinations that best suit your individual needs.

The Future of Selsun Blue and Skin Treatment Research

As dermatological research continues to advance, what might the future hold for Selsun Blue and similar treatments? While it’s impossible to predict with certainty, several exciting avenues of research are worth noting:

Potential New Applications

Researchers are exploring the potential of selenium sulfide and related compounds in treating a wider range of skin conditions. This could potentially lead to new formulations or expanded uses for products like Selsun Blue. Areas of interest include:

• Acne treatment
• Management of other fungal skin infections
• Potential applications in hair loss prevention

Improved Formulations

Future iterations of Selsun Blue might feature:

• Enhanced delivery systems for better penetration and efficacy
• Combination with other active ingredients for synergistic effects
• More cosmetically elegant formulations to improve user experience
• Specialized versions for different hair and skin types

Personalized Treatment Approaches

As our understanding of individual skin microbiomes grows, we may see a shift towards more personalized treatment regimens. This could involve:

• Customized formulations based on an individual’s specific scalp flora
• Integration with genetic testing to predict treatment responsiveness
• Tailored treatment plans that combine multiple approaches for optimal results

While these developments are still on the horizon, they underscore the ongoing importance of products like Selsun Blue in the dermatological landscape. As research progresses, we can look forward to even more effective and targeted treatments for a range of skin and scalp conditions.

Selsun Blue Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used to treat dandruff and a certain scalp infection (seborrheic dermatitis). It reduces itching, flaking, irritation, and redness of the scalp. Selenium sulfide is also used for a condition that causes discoloration of the skin (tinea versicolor). This medication belongs to a class of medications called anti-infectives. It works by slowing the growth of the yeast that causes the infection.

How to use Selsun Blue 1 % Shampoo

This medication is for use on the skin only. Some brands require shaking before use. Check your product package to see if your brand needs to be shaken. Before using this medication, remove any jewelry to avoid damage to it. Avoid getting this medication into your eyes, inside your nose or mouth, or on any areas of broken/inflamed skin since it may cause irritation. If this occurs, flush the area with plenty of water. Consult your doctor or pharmacist if you have any questions about how to use this medication properly.

For the treatment of dandruff or scalp dermatitis, follow the manufacturer’s instructions, or use as directed by your doctor. Wet the scalp and massage the medication onto the wet scalp. Leave it on your scalp for 2-3 minutes and rinse thoroughly. Some brands may require a second application. Check your product package to see if your brand requires a repeat application. Be sure to rinse your hair and scalp well with water after each application, especially on bleached, tinted, or permed hair. This medication is usually used 1 or 2 times per week to treat dandruff or seborrheic dermatitis, or less often to maintain control of dandruff.

For the treatment of tinea versicolor, apply selenium sulfide to the affected skin. Lather with a small amount of water. Allow it to remain on your skin for 10 minutes. Rinse your skin thoroughly with water after each use. If the medication touches the genital areas or skin folds, rinse the area well with water for a few minutes to prevent irritation. This medication is applied usually once daily for 7 days to treat tinea versicolor, or use as directed by your doctor.

Wash your hands after using selenium sulfide. Do not leave this medication on your hair, scalp, or skin for a longer period or use it more often than directed. Your condition will not clear faster, but side effects may be increased.

If your condition worsens or does not improve, tell your doctor or pharmacist promptly.

Side Effects

Skin irritation, dry skin, oily or dry hair/scalp, or temporary hair loss may occur. If any of these effects last or get worse, discontinue use and consult your doctor or pharmacist promptly. Hair discoloration may occur and can be reduced by carefully rinsing the hair thoroughly after each treatment.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using selenium sulfide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: red/irritated/broken skin.

This medication is not recommended for children younger than 2 years. Consult your doctor before using this medication.

If you are using selenium sulfide on the body for tinea versicolor, this medication should be used during pregnancy only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Selsun Blue 1 % Shampoo interact with other drugs you are taking?

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Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Keep all medical and lab appointments.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Avoid freezing. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

How To Use, Benefits, And Side Effects

Selsun Blue is a common trade name for selenium sulfide. It is used commonly in anti-dandruff shampoos. It reduces scalp greasiness and itchiness and slows down the growth of dandruff-causing skin cells on the scalp. Besides, anecdotal evidence suggests that using Selsun Blue on the skin may help treat several skin conditions apart from an itchy scalp.

But what does science say? Is Selsun Blue safe to use on the skin? Or does it cause more harm? In this article, we discuss the benefits of Selsun Blue for skin and its potential risks. Keep reading.

In This Article

Benefits Of Selsun Blue For Skin

The Selsun shampoo contains selenium sulfide, a substance that effectively treats a number of scalp disorders like dandruff and psoriasis by reducing inflammation and inhibiting the proliferation of skin cells. Keep reading to know more Selsun shampoo uses and benefits that you should know about.

1. May Help Treat Thickening Of Skin

Image: Shutterstock

A study suggests that topical application of a selenium sulfide lotion or shampoo may treat hyperkeratosis (thickening of skin’s outer layer), especially involving palms and soles (1). As part of the study, three individuals with hyperkeratosis were successfully treated with selenium sulfide in either a 2.5% lotion/shampoo or a 2.75% foam without any adverse effects. Besides, the response was not only rapid but also complete and sustained.

Trivia

In the US, 1.5% selenium sulfide is available over the counter. However, you’ll need a prescription to get 2.5% selenium sulfide. However, in Canada, 2.5% is the maximum strength of selenium sulfide sold over the counter.

2. May Help Treat Seborrheic Dermatitis

Image: Shutterstock

This skin condition is characterized by red patches with yellow-gray scales that mostly appear on the face, scalp, upper chest, and back. A study found that selenium sulfide used in concentrations of 0.5% to 2.5% in lotion, ointment, cream, and jelly vehicles may help treat the skin condition effectively. Besides, concentrations of 0.5% and 1% were found to be less irritating than and as effective as the higher concentrations (2).

This disease may often occur in conjunction with other skin conditions like acne vulgarisⁱ  XA skin condition caused by inflammation and obstruction of the hair follicles by oil and dead skin cells. and eczema (3). Hence, treating seborrheic dermatitis may help reduce the flare-up of these conditions, as it works as an anti-infective agent.

Related: 4 Remedies For Seborrheic Dermatitis Hair Loss & Treatment

3. May Help Treat Pityriasis Versicolor

Image: Shutterstock

Pityriasis (tinea) versicolor is a skin condition that causes hyperpigmented and hypopigmented scaly patches. It is caused by the fungus Malassezia furfur. Research suggests that selenium sulfide may treat this skin condition effectively with its antifungal properties, besides showing better efficacy than sodium sulfacetamideⁱ  XA medication with antibiotic properties that is applied topically to treat pimples and seborrheic dermatitis. (4). However, it may cause certain adverse effects. Hence, practice caution.

Related: 3 Ways To Treat Hyperpigmentation And Tips To Prevent It

4. May Help Treat Rashes

Image: Shutterstock

Selenium sulfide is an antifungal agent. Anecdotal reports suggest that it may be used to treat skin rashes. However, consult a dermatologist before using Selsun Blue for rashes as it may cause side effects in some individuals.

These are the potential skin benefits of Selsun Blue. But how do you use it for achieving the desired results?

How To Use Selsun Blue For Skin

Image: Shutterstock

Related: How To Get Rid Of Dandruff Naturally – 18 Tips And Remedies

•  Selsun Blue is meant for use on the skin only. Ensure you shake the package before use (as directed on the package). Remove jewelry before using the product. Rinse your hair and scalp before applying the product to treat seborrheic dermatitis or scalp dandruff. Massage the product in and leave it on for the prescribed duration. Check the label to understand if the product can be used on color-safe and processed hair. Keep in mind that each skin or hair care product may have slightly different application instructions, so be sure to look out for those.
•  For tinea versicolor, apply selenium sulfide to the affected area. Add a few drops of water to form lather. Leave it on the skin for about 10 minutes and wash off.
•  Wash your hands after using selenium sulfide. Do not leave this medication on your hair, scalp, or skin for a longer period. Also, do not use it more often than directed.
•  Consult a doctor or pharmacist if your condition worsens or does not improve despite using Selsun Blue.

Note: Do not apply any products containing Selsun Blue into your eyes, nose, or mouth. Avoid applying it to broken or inflamed skin, unless directed by a medical professional, as it may cause swelling and irritation.

Quick Tip

The United States approved using selenium sulfide for medical purposes around 1951. The chemical is also included in the World Health Organization (WHO) Essential Medicines List.

Selenium compounds are not easily absorbed through the skin. Hence, using medicated shampoos containing selenium is generally considered safe. However, one may still experience side effects like contact dermatitisⁱ  XAn itchy rash on the skin caused by contact with a specific substance or allergen, making the skin red and inflamed. (5). Read to know the other side effects of Selsun Blue in the following section.

Selsun Blue: Side Effects And Precautions

The side effects of Selsun Blue include (6):

•  Redness, burning, itching, stinging, and irritation of the skin
•  Scalp sores, increased skin oiliness, and nail hyperpigmentation
•  Scalp hyperpigmentation
•  Scalp discoloration
•  Alopecia (hair loss)
•  Rarely, nausea may occur due to the medication’s odor

Note: Children aged below five years and women who are pregnant or breastfeeding should not use Selsun shampoo.

Do not use Selsun shampoo if:

• You are allergic (hypersensitive) to selenium sulfide or any of the other ingredients of the medicated shampoo. You should always do a patch test before using it as directed for your condition to ensure that you do not have any sensitivities to the product.
• You have broken or severely inflamed skin

Do you know that food we take contains selenium? But does it make the food healthy or harmful? Keep scrolling to know the answers.

Is It Wrong To Eat Food With Selenium?

No. Selenium is an essential nutrient for humans and animals. People receive a majority of their daily selenium intake from food, and to a lesser extent, from water. However, selenium can be harmful when regularly taken in amounts higher than those needed (6).

The seriousness of the adverse effects depends on how much selenium is taken and how often. Brittle hair and deformed nails can develop even if mildly excessive amounts of selenium are taken over long periods.

Anecdotal evidence suggests that people may also lose feeling and control in their arms and legs in extreme cases. Swallowing a large amount of selenium supplement pills could be life-threatening without immediate treatment.

In A Nutshell

Selsun Blue or selenium sulfide is a common ingredient in anti-dandruff shampoos. The antifungal properties of the ingredient help protect the skin from infections and treat several skin issues. The benefits of Selsun Blue include treating skin conditions like tinea versicolor, dermatitis, rashes, and hyperkeratosis. You can use this ingredient on your skin and hair, but remove your jewelry before using it. Also, do not keep the skin in contact with this ingredient for more than the prescribed duration. It may also cause side effects like discoloration, blistering, and rashes. Finally, always use the product as per the instructions given outside the package or by a doctor.

Frequently Asked Questions

Can you sleep with Selsun Blue on?

No. Leaving Selsun Blue on your skin for too long may result in an allergic reaction (6). Ensure you follow the instructions for safe results.

Can we use Selsun Blue for skin psoriasis?

Yes. Scientific evidence suggests that topical selenium sulfide may effectively improve psoriatic plaques (1).

Does Selsun Blue get rid of white spots on skin?

Yes. Selsun Blue has antifungal properties that may treat the white spots (hypopigmentation) on the skin (7). Consult your doctor for proper instructions and dosage.

Can we use selenium sulfide for burnt skin?

There is currently no research to support the use of Selsun Blue on burnt skin. Consult a doctor for more information.

How long should you leave Selsun Blue on sunspots?

Leave Selsun Blue on the affected areas for 10 to 15 minutes before washing it off with water.

Key Takeaways

• Selsun Blue (or selenium sulfide) is a common ingredient in anti-dandruff shampoos that also reduces scalp greasiness.
• It works as an antifungal agent and reduces the risk of infections, such as tinea versicolor, flaky scalp, and seborrheic dermatitis.
• Selsun Blue should only be applied to the skin and left on for the prescribed time duration.

Learn how to use anti-dandruff shampoo safely and effectively to clear up acne. Check out this video to get more information.

References:

Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Read our editorial policy to learn more.

1. Topical Selenium Sulfide for the Treatment of Hyperkeratosis
   https://www.researchgate.net/publication/327564660_Topical_Selenium_Sulfide_for_the_Treatment_of_Hyperkeratosis
2. Observations on the Use of Selenium Sulfide and Hydrocortisone Ointment
   https://jamanetwork.com/journals/jamadermatology/article-abstract/524873
3. Seborrheic Dermatitis and Malassezia species
   https://www. ncbi.nlm.nih.gov/labs/pmc/articles/PMC2923939/
4. A Double-Blind Comparative Study of Sodium Sulfacetamide Lotion 10% Versus Selenium Sulfide Lotion 2.5% in the Treatment of Pityriasis (Tinea) Versicolor
   https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/073060425.pdf
5. CONTACT DERMATITIS FROM SELENIUM SULFIDE SHAMPOO
   https://jamanetwork.com/journals/jamadermatology/article-abstract/524452
6. Selenium
   https://www.ncbi.nlm.nih.gov/books/NBK557551/
7. Tinea Versicolor – An Epidemiology
   https://www.researchgate.net/publication/45459485_Tinea_Versicolor_-_An_Epidemiology

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A cream has been developed to eliminate and prevent vitiligo spots on the skin – Newspaper.Ru

A cream has been developed to eliminate and prevent vitiligo spots on the skin – Gazeta.Ru | News

June 06, 2023, 10:26

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At the Clinic of Skin and Venereal Diseases of Sechenov University in cooperation with the Institute of Pharmacy named after A. I. A.P. Nelyubina created a new cream for the treatment of vitiligo based on carnosine, a domestically developed antioxidant. Previously, carnosine was not used in the treatment of vitiligo. This was reported to Gazeta.Ru at the First Moscow State Medical University named after I.M. Sechenov.

The cream is aimed at preventing the progression of the disease, that is, it prevents the appearance of new spots.

Vitiligo is a discoloration of the skin, characterized by the appearance of discolored, often symmetrically located spots of various sizes and shapes, milky white in color. For health, this disease is not dangerous, but some spots of vitiligo seem ugly, causing psychological discomfort. Today in Russia, about 4% suffer from vitiligo.

“The fact is that in vitiligo, oxidative processes occur in the skin, and imported antioxidant drugs are quite expensive, so we have developed a domestic drug based on carnosine. At present, we have started its preclinical studies,” Konstantin Lomonosov, professor at the Clinic for Skin and Venereal Diseases at Sechenov University, told Gazeta. Ru.

Treatment of vitiligo is a very time-consuming process and includes a whole range of different medicines (ointments, tablets, injections) and physiotherapy methods, which should be selected individually for the patient, taking into account his age, comorbidity, prescription, degree of progression, localization and prevalence of the disease.

Currently, Sechenov University is working on the creation of a progressive method for the treatment of vitiligo using cell technologies. The new method will make it possible to obtain a pronounced and longer therapeutic effect in patients with vitiligo who are resistant to other methods of treating the disease.

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90,000 own clinical experience. Scientific section of the IAKI clinic

Konstantinova Veronika Albertovna

Dermatologist, cosmetologist, Institute of Allergology and Clinical Immunology, Moscow

Abstract

Oxidative stress is considered one of the reasons for the violation of melanogenesis, leading to the development of vitiligo. In the scientific literature, there are reports that melanocytes in the foci of vitiligo retain their viability, but their pigment-forming function is suppressed. Under the influence of some stimuli, they can restore their activity, in particular, a therapeutic effect is noted not only from the use of selective phototherapy with UV radiation, but also from the use of antioxidants.

In this article, the author describes his own clinical experience of successfully treating patients with vitiligo using intradermal injections of an antioxidant cocktail.

Key words: vitiligo, antioxidants, mesotherapy.

Introduction

Vitiligo is one of the most common types of hypomelanosis. According to official data, it affects from 3 to 6% of the world’s population (the largest number of cases was recorded in Asia and the Middle East). however, in recent years, it appears that the number of patients with vitiligo has been steadily increasing. Recall that dyschromia is manifested by depigmentation spots due to the loss of the ability to produce melanin in certain areas of the skin. This is due to the absence of the tyrosinase enzyme in melanocytes, which stimulates the process of pigment formation. Due to the presence of a pronounced cosmetic defect, patients with vitiligo experience severe stress and psycho-emotional discomfort. This dictates to clinicians and researchers the need to find new ways to treat this disease.

Currently, the lack of a holistic concept of the pathogenesis of vitiligo makes it difficult to develop a unified approach to treatment and predict the clinical course of this disease. In a number of scientific studies of the pathogenesis of vitiligo, various theories are preferred: genetic, neurogenic, autoimmune, the theory of oxidative stress, etc. All these theories have been repeatedly confirmed experimentally, but scientists have not yet come to a consensus. In addition, there are also a number of provoking factors: exposure to UV radiation, psycho-emotional stress, changes in the state of the peripheral nervous system, etc.

Pathogenetic features of vitiligo

In recent years, scientists around the world are increasingly inclined to the leading role of oxidative stress in the development of vitiligo. Man, like other aerobic organisms, needs oxygen for his life. however, a significant increase in the level of oxygen in the tissues is detrimental to aerobes. It is not oxygen itself that has a toxic effect, but its so-called active forms (ROS), some of which are free radicals. Normally, the formation and breakdown of ROS are in a state of balance, and they do not accumulate in cells. The content of ROS can increase with an increase in the rate of their formation or a decrease in the ability of cells to neutralize them. The combination of these processes creates conditions for oxidative stress. At the cellular level, there are disturbances in the functioning of the electron transport chains of mitochondria or microsomes, changes in the activity of enzymes (including dehydrogenases – enzymes that catalyze the reactions of biological oxidation and reduction), lipid peroxidation.

The trigger factor for the formation of ACF in the body is exposure to UV radiation. In moderate doses, it stimulates melanogenesis, which manifests itself in the form of a tan. But with an increase in the intensity and duration of exposure, direct damage to melanocytes is possible, including due to disruption of the work of the cell’s own antioxidant systems [7]. In addition, under the influence of UV rays, the activity of the sympathetic division of the autonomic nervous system increases and the synthesis of catecholamines increases, which suppress the production of melanin, the main chromophore that absorbs UV rays. All this together leads to an increase in the level of ACE in the blood plasma, epidermis, interstitial fluid of depigmented areas of the skin of patients with vitiligo, contributing to the development and progression of the disease.

The drug of choice and treatment tactics

There are reports in the scientific literature that melanocytes remain viable in vitiligo foci, but their pigment-forming function is suppressed. however, under the influence of some stimuli, they can restore their activity [9]. In particular, there is a therapeutic effect from the use of not only ultraviolet (selective phototherapy), but also antioxidants.

The idea of ​​using NCTF135 (FILLMED, Laboratoires Filorga) in the treatment of vitiligo to reduce the effect of oxidative stress on melanocytes arose naturally from the analysis of its composition. it includes a polyrevitalizing complex of 55 active ingredients (13 vitamins, 23 amino acids, 6 minerals, 6 coenzymes, 5 nucleotides, glutathione and hyaluronic acid at a concentration of 0.025 mg/ml). It is known that the antioxidant system of the body is multicomponent and is divided into extra- and intracellular protection. it is represented by non-enzymatic substances (for example, tocopherols, carotenoids, ascorbic acid, uric acid, glutathione) and true enzymes (superoxide dismutase, catalase, transferase, etc. ) [8]. If you carefully study the components of the NCTF135 preparation, then it includes glutathione, hyaluronic and ascorbic acids, tocopherol (vitamin e) as antioxidants. All of them are the most important link in the protection of cells from ROS. With an increase in the intracellular concentration of glutathione, the antioxidant protection of cells increases and their trophism improves. In addition to antioxidants, NCTF135 contains hyaluronic acid, which activates neoangiogenesis, improving blood circulation in the injection area. Against this background, the introduced vitamins and microelements are better absorbed, cell proliferation is activated and the main metabolic processes in them proceed more intensively.

NCTF135 is well established in the treatment of a number of skin diseases, but we did not find any mention of the use of intradermal injections of antioxidants in vitiligo lesions. In addition, vitiligo is also absent from the list of indications for the use of NCTF135. Therefore, in this case, we can only talk about “off label” therapy, i.e. use of the drug for indications not approved by state regulatory authorities and / or not mentioned in the instructions for use. It should be noted that many medicines are used in the “off label” mode in modern medical practice in the Russian Federation, so our observation is not something extraordinary from a legal point of view.

Clinical observations

Under our supervision there were 7 patients (all women) aged 25 to 54 years. Complaints when applying for rashes in the form of multiple white spots of various shapes and sizes on the skin of the face, neck, trunk and extremities. Most of them have been sick since childhood, one patient noted the onset of the disease during pregnancy. In all patients, rashes (at the time of therapy initiation) were of a progressive nature. Heredity is not burdened: blood relatives do not have vitiligo. Allergological anamnesis is not burdened.

All patients observed by us were examined to rule out concomitant diseases. In particular, a clinical blood test, a biochemical blood test, and thyroid function (including ultrasound) were checked. In all patients, the level of TSH, T3 free, T4 free, AT to TPO and AT to TG was determined in the blood. In 2 out of 7 patients, an elevated level of antibodies to TG was detected (in one patient, the norm was exceeded by 3 times, in the second – by 50 times). both patients were consulted by an endocrinologist with a diagnosis of autoimmune thyroiditis. These patients were observed by an endocrinologist without prescribing symptomatic therapy. No other pathology from the internal organs was revealed. Prior to the start of mesotherapy, the patients received the treatment presented in the table.

• Patient 1: course of vitamin therapy (3 months), 2-month course of topical agents (ointment Protopic 0.1%) 2 times a day. The treatment was completed 4 months before the start of mesotherapy and, according to the patient, had no effect.
• Patient 2: previously used celandine tincture for 1. 5 months without any visible effect. The treatment was completed 2 months before the start of mesotherapy.
• Patients 3 and 4: previously untreated. The diagnosis was established initially.
• Patient 5: received a course of selective phototherapy 311 nm (3 times a week, 20 sessions) without visible effect. The treatment was completed 5 months before the start of mesotherapy.

rice. Fig. 1. Patient 3: vitiligo foci in the area of ​​the hands before (a) and 2 weeks after the course of NCTF135 (B)

rice. Fig. 3. Patient 5: vitiligo lesions in the décolleté before (a) and 2 weeks after the course of NCTF135 (B)

rice. Fig. 4. Patient 7: vitiligo foci in the face and neck before the course of NCTF135 (a, B) and 2 weeks after the end of the course of NCTF135 (c, D)

Patients 6 and 7: received a course of excimer laser (10 sessions each) with 1st and 2nd degree burns in the area of ​​the foci. however, according to the patients, they did not observe repigmentation after restoring the integrity of the skin in the foci. The treatment was completed 8 and 12 months before the start of mesotherapy, respectively.

Despite the lack of clinical improvement after previous treatment, all patients were motivated to undergo mesotherapy.

At the time of examination, depigmented white spots were localized on the skin of the periorbital and perioral areas, neck and décolleté, hands, axillary areas, and inner thighs (Fig. 1a, 2a, 3a, 4a, B). Photofixation of the foci was carried out before the start of therapy and 2 weeks after the 5th procedure.

Procedure protocol

Before starting therapy, all patients participating in the study signed an informed consent for the off label procedure and permission to publish their photographs in scientific journals.

The course of mesotherapeutic procedures with NCTF135 consisted of 5 sessions with a frequency of 1 time per week.
Previously, Emla cream was used for 30–45 minutes as a local anesthesia for patients. Then the NCTF135 preparation was injected in a volume of 3.0 ml intradermally, by papular technique, at a distance of approximately 1.0 cm from each other (Fig. 5). A 30G × 13 mm needle was used for injections. The duration of the procedure was 15–20 min (excluding the time of anesthesia).

Results

During therapy, all 7 patients showed the disappearance of a sharp border between lesions and healthy skin (“levelling” of the outer boundaries of lesions), as well as complete or partial repigmentation in lesions previously devoid of pigment. natural pigmentation was restored both along the periphery and in the central part of the lesions [10]. Moreover, in 6 patients, spotted (“mosaic”) repigmentation was visually recorded in all lesions in which intradermal injections of the drug were performed (Fig. 1B, 2B, 3B), and in one patient, almost complete repigmentation in the focus at the right corner of the mouth. In addition, in the last patient, on the lateral surface of the neck on the left, the focus decreased in size, was partially repigmented, and was divided into two parts by the isthmus (Fig. 4c, D).

After the therapy, the patients began to notice a decrease in the sensitivity of depigmented lesions to sunlight. Short-term exposure to UV light no longer caused pronounced prolonged hyperemia in the lesions, as it was before treatment. During the mesotherapy course, there were no allergic reactions or exacerbation of the underlying disease (appearance of new spots). At the end of the course of therapy, as a preventive measure, the patients were recommended sunscreens with SPF 50+.

At further follow-up (6 months after completion of the course of mesotherapy), repigmentation in all patients was persistent and accounted for about 30% of the entire affected area. Six months after the 1st course of mesotherapy with antioxidants, 2 out of 7 patients received a second course of mesotherapy with the same drug. As a result, the process of repigmentation in the foci continued and amounted to about 15–20% of the entire area of ​​depigmentation. the remaining 5 people refused to continue treatment due to financial difficulties.

Thus, in total, in 2 patients after two courses of mesotherapy with antioxidants, persistent repigmentation amounted to 50% of the total area of ​​the lesion. This allows us to talk about a persistent effect of repigmentation in vitiligo foci after an injection course of antioxidants, as well as an increasing effect with repeated course use of the drug.

rice. 5. intradermal injections (patient 7) in lesions on the skin of the face (a) and neck (B)

Conclusion

These results clearly demonstrate the effectiveness of combined preparations with antioxidants (in particular, NCTF135) in restoring natural pigmentation in vitiligo lesions.