What is cefpodoxime used for. How does cefpodoxime work. What are the common side effects of cefpodoxime. How should cefpodoxime be taken. Are there any interactions with cefpodoxime. What precautions should be taken when using cefpodoxime.

Understanding Cefpodoxime: A Powerful Antibiotic

Cefpodoxime is a cephalosporin antibiotic used to treat various bacterial infections. This broad-spectrum antibiotic is effective against a wide range of bacteria, making it a versatile choice for healthcare providers. Cefpodoxime is available as tablets and oral liquid medicine, providing flexibility in administration for different patient needs.

How does cefpodoxime work?

Cefpodoxime works by interfering with the bacterial cell wall synthesis. It binds to specific proteins called penicillin-binding proteins (PBPs) in the bacterial cell wall, inhibiting the final step of peptidoglycan synthesis. This action weakens the cell wall, leading to bacterial cell lysis and death.

Common Uses of Cefpodoxime

Cefpodoxime is prescribed for various bacterial infections, including:

• Urinary tract infections
• Respiratory tract infections (chest and throat)
• Skin and soft tissue infections
• Sinusitis

Can cefpodoxime treat viral infections? No, cefpodoxime is only effective against bacterial infections. It will not work for colds, flu, or other viral infections.

Proper Administration of Cefpodoxime

To ensure the best results from cefpodoxime treatment, follow these guidelines:

1. Take the medicine with a full glass of water.
2. Follow the dosage instructions on the prescription label.
3. Shake the oral suspension well before use.
4. Use a specially marked spoon or container for accurate measurement.
5. Take the medicine at regular intervals as directed.
6. Complete the full course of treatment, even if you feel better.

Is it necessary to take cefpodoxime with food? Cefpodoxime can be taken with food or on an empty stomach, depending on your healthcare provider’s instructions.

Potential Side Effects of Cefpodoxime

While cefpodoxime is generally well-tolerated, some patients may experience side effects. These can be categorized into common and serious side effects:

Common Side Effects

• Diarrhea
• Nausea or vomiting
• Stomach upset or gas
• Headache
• Dizziness or drowsiness
• Joint or muscle pain
• Trouble sleeping

Serious Side Effects

Serious side effects are rare but require immediate medical attention:

• Allergic reactions (skin rash, itching, hives, swelling of face, lips, or tongue)
• Breathing problems
• Severe skin reactions (fever, flu-like symptoms, rash, blistering, or peeling skin)
• Unusual weakness or tiredness
• Fast or irregular heartbeat
• Vaginal irritation or discharge

Do side effects of cefpodoxime always require medical attention? While common side effects often resolve on their own, serious side effects should be reported to a healthcare provider immediately.

Important Precautions and Interactions

Before taking cefpodoxime, inform your healthcare provider about:

• Any allergies, especially to cephalosporins, penicillins, or other antibiotics
• Medical conditions, particularly kidney disease or bowel disorders
• Pregnancy or breastfeeding status
• All medications, supplements, and herbal products you are taking

Cefpodoxime may interact with certain medications, including:

• Antacids
• Diuretics
• Probenecid
• Stomach acid reducers (e.g., cimetidine, famotidine, omeprazole)

Should you avoid alcohol while taking cefpodoxime? While there are no specific alcohol-related warnings for cefpodoxime, it’s generally advisable to avoid alcohol during antibiotic treatment to support your body’s healing process.

Dosage Guidelines for Cefpodoxime

Cefpodoxime dosage varies depending on the type and severity of the infection, as well as the patient’s age and overall health. Typical dosages include:

• Adults: 100-400 mg twice daily
• Children (2 months and older): 5-10 mg/kg/day, divided into two doses

The duration of treatment usually ranges from 5 to 14 days, depending on the infection being treated.

What should you do if you miss a dose of cefpodoxime? Take the missed dose as soon as you remember. If it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.

Storage and Handling of Cefpodoxime

Proper storage of cefpodoxime is crucial for maintaining its effectiveness:

• Keep the medication out of reach of children
• Store tablets at room temperature, away from heat and moisture
• Refrigerate the oral suspension between 2-8°C (36-46°F)
• Do not freeze the oral suspension
• Discard any unused oral suspension after 14 days

How long can you keep cefpodoxime oral suspension after mixing? Once mixed by your pharmacist, the oral suspension should be used within 14 days and kept refrigerated.

Special Considerations for Cefpodoxime Use

While cefpodoxime is an effective antibiotic, there are some special considerations to keep in mind:

Use in Pediatric Patients

Cefpodoxime can be prescribed for children as young as 2 months old for certain conditions. However, special care and dosage adjustments may be needed. Always consult with a pediatrician regarding the use of this medicine in children.

Pregnancy and Breastfeeding

If you are pregnant, trying to conceive, or breastfeeding, discuss the risks and benefits of cefpodoxime use with your healthcare provider. While cefpodoxime is generally considered safe during pregnancy, it’s important to weigh the potential risks against the benefits of treating the infection.

Antibiotic Resistance

To prevent the development of antibiotic-resistant bacteria, it’s crucial to use cefpodoxime only as prescribed. Do not use it for viral infections, and complete the full course of treatment even if you start feeling better.

Can cefpodoxime contribute to antibiotic resistance? Like all antibiotics, improper use of cefpodoxime can contribute to the development of antibiotic-resistant bacteria. Always follow your healthcare provider’s instructions carefully.

Monitoring During Treatment

Your healthcare provider may recommend regular check-ups or laboratory tests to monitor your response to cefpodoxime and check for any potential side effects, especially if you’re on a long-term treatment plan or have underlying health conditions.

Alternatives to Cefpodoxime

While cefpodoxime is effective for many bacterial infections, there may be situations where alternative antibiotics are preferred. Some alternatives include:

• Other cephalosporins (e.g., cefuroxime, cefixime)
• Penicillins (e.g., amoxicillin, ampicillin)
• Fluoroquinolones (e.g., ciprofloxacin, levofloxacin)
• Macrolides (e.g., azithromycin, clarithromycin)

The choice of antibiotic depends on various factors, including the type of infection, bacterial susceptibility, patient allergies, and potential drug interactions.

Are there natural alternatives to cefpodoxime? While some natural remedies may have antimicrobial properties, they are not substitutes for prescribed antibiotics in treating bacterial infections. Always consult with your healthcare provider before considering any alternative treatments.

Cefpodoxime in Clinical Practice

Cefpodoxime has proven to be a valuable tool in the treatment of various bacterial infections. Its broad-spectrum activity makes it particularly useful in empiric therapy, where the specific causative organism is unknown. Some key points about cefpodoxime in clinical practice include:

Efficacy in Respiratory Tract Infections

Cefpodoxime has shown excellent efficacy in treating community-acquired pneumonia, acute exacerbations of chronic bronchitis, and acute bacterial sinusitis. Its ability to penetrate respiratory tissues makes it a good choice for these infections.

Urinary Tract Infections

For uncomplicated urinary tract infections, cefpodoxime has demonstrated high cure rates and good tolerability. It’s particularly useful in cases where resistance to first-line antibiotics is a concern.

Skin and Soft Tissue Infections

Cefpodoxime is effective against many of the common pathogens causing skin and soft tissue infections, including Staphylococcus aureus and Streptococcus pyogenes.

How does cefpodoxime compare to other antibiotics in terms of efficacy? While cefpodoxime is highly effective for many infections, its comparative efficacy depends on the specific infection and local resistance patterns. Your healthcare provider will consider these factors when choosing the most appropriate antibiotic.

Patient Education and Compliance

Proper patient education is crucial for the successful use of cefpodoxime and to prevent antibiotic resistance. Key points to emphasize include:

• The importance of completing the full course of antibiotics
• Proper storage and handling of the medication
• Potential side effects and when to seek medical attention
• The need to inform healthcare providers about all medications and supplements being taken
• The importance of taking the medication at regular intervals as prescribed

How can patients improve their compliance with cefpodoxime treatment? Setting reminders, using pill organizers, and understanding the importance of completing the full course can help improve compliance. If side effects are a concern, discuss them with your healthcare provider rather than discontinuing the medication on your own.

Future Developments and Research

As with all antibiotics, ongoing research is crucial to understand the evolving patterns of bacterial resistance and to develop new strategies for using cefpodoxime effectively. Some areas of current research include:

• Combination therapies to enhance efficacy and reduce resistance
• Development of new formulations for improved bioavailability
• Studies on the use of cefpodoxime in specific patient populations (e.g., elderly, immunocompromised)
• Investigation of cefpodoxime’s potential in treating emerging infectious diseases

What new developments can we expect in cefpodoxime research? While specific predictions are difficult, research is likely to focus on optimizing dosing regimens, exploring new indications, and developing strategies to combat antibiotic resistance.

In conclusion, cefpodoxime remains an important antibiotic in the treatment of various bacterial infections. Its broad-spectrum activity, good tissue penetration, and favorable safety profile make it a valuable option for healthcare providers. However, as with all antibiotics, it should be used judiciously to preserve its effectiveness and prevent the development of antibiotic resistance. Patients should always follow their healthcare provider’s instructions carefully and report any concerns or side effects promptly.

Cefpodoxime oral suspension

What is this medicine?

CEFPODOXIME (sef pode OX eem) is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Vantin

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• bleeding problems
• bowel disease, like colitis
• kidney disease
• other chronic illness
• an unusual or allergic reaction to cefpodoxime, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take with food or on an empty stomach. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine early even if you feel better.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 2 months of age for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• antacids
• diuretics
• medicines for stomach acid or ulcer like cimetidine, famotidine, lansoprazole, nizatidine, omeprazole, ranitidine
• probenecid
• sodium bicarbonate

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care provider if your symptoms do not improve or if you get new symptoms.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• confused, nervous, shaky
• fast or irregular heartbeat
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• unusually weak or tired
• vaginal irritation, discharge

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• dizzy, drowsy
• dry mouth
• headache
• joint or muscle pain
• stomach upset, gas
• trouble sleeping
• vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

After this medicine is mixed by your pharmacist, store it in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Throw away any unused medicine after 14 days.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Cefpodoxime for infections. Cefpodoxime info – Patient

About cefpodoxime

Cefpodoxime is a broad-spectrum antibiotic, which means that it is active against a wide variety of bacteria. It is used to treat bacterial infections such as urinary tract infections, chest and throat infections, skin infections and sinusitis. Cefpodoxime treats an infection by killing the bacteria that are causing it.

Some people who are allergic to penicillin antibiotics may not be able to take cefpodoxime, so make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic.

Before taking cefpodoxime

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking cefpodoxime it is important that your doctor knows:

• If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have had a bad reaction to a penicillin or cephalosporin antibiotic.
• If you have any problems with the way your kidneys work.
• If you are pregnant, trying for a baby or breastfeeding. (Although cefpodoxime is not known to be harmful to babies, it is still important that you tell your doctor if you are expecting or breastfeeding a baby.)
• If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to take cefpodoxime

• Before you start taking cefpodoxime, read the manufacturer’s printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about the antibiotic and a full list of side-effects which you may experience from taking it.
• Usual doses of cefpodoxime are as follows, but they are intended as a guide only. Your doctor will tell you what dose is right for you (or your child), and this information will be printed on the label of the pack to remind you. You should take cefpodoxime exactly as your doctor tells you to:
  • Adults: 1 or 2 tablets twice daily, morning and evening.
  • Children aged over 9 years: 1 tablet twice daily, morning and evening.
  • Children aged 3-8 years: 10 ml twice daily, morning and evening.
  • Children aged 6 months-2 years: 5 ml twice daily, morning and evening.
• If you have been given liquid medicine for your child, read the directions carefully to make sure you measure out the correct amount of medicine. There is 40 mg of cefpodoxime in each 5 ml of medicine.
• Take cefpodoxime with a snack or just after eating a meal, as this will help your body to absorb the medicine. Space your doses out evenly throughout the day.
• Your doctor will tell you how long the course of treatment will last – this is commonly about five days. Keep taking the antibiotic until the course is finished unless you are told to stop by your doctor. Taking the full course is important (even if you feel your infection has cleared up) in order to prevent the infection from coming back.
• If you forget to take a dose, take one as soon as you remember. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

• Some people develop thrush (redness and itching in the mouth or vagina) after taking a course of antibiotics. If you think you have thrush speak with your doctor or pharmacist for advice.
• Antacids reduce the amount of cefpodoxime that your body absorbs. Because of this, it is recommended that you do not take indigestion remedies during the two hours before or the two hours after you take cefpodoxime.
• If you are using oral combined hormonal contraception (the ‘pill’), additional contraceptive precautions such as condoms are recommended for a time if you have sickness (vomiting) or diarrhoea which lasts for more than 24 hours. If you need further advice about this, speak with your doctor or pharmacist.
• If you are having an operation or any other medical treatment, tell the person carrying out the treatment that you are taking an antibiotic. This is because cefpodoxime may interfere with the results of some tests to check for sugar in urine.
• Cefpodoxime may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this antibiotic.

Can cefpodoxime cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cefpodoxime. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: if you develop an itchy rash, swollen face or mouth, or have difficulty breathing, these can be signs that you are allergic to the antibiotic. Do not take any more cefpodoxime and speak with your doctor or go to your local accident and emergency department straightaway.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

How to store cefpodoxime

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.
• If you have been given liquid medicine, store it in a refrigerator. It will have been made up by the pharmacy, so remember to check the expiry date on the bottle and do not use it after this date. 

Important information about all medicines

Cefpodoxime Proxetil | 1800PetMeds

What is Cefpodoxime Proxetil?

Cefpodoxime proxetil is an oral cephalosporin antibiotic used to treat bacterial infections of the skin, such as wounds and abscesses as well as bladder and respiratory infections in dogs and skin and soft tissue infections in cats. It does not treat viral or parasitic infections. Cefpodoxime proxetil is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to prescribe this product for dogs and it may be useful in cats as well. Cefpodoxime proxetil requires a prescription from your veterinarian.

For:

Dogs & Cats

Benefits:

• Treats bacterial skin, bladder and respiratory infections in dogs
• Treats skin & soft tissue infections in cats
• Simple oral once-daily dosing
• Can be given with or without food
• Comes in a film-coated tablet for easy administration

How does cefpodoxime proxetil work?

Cefpodoxime proxetil is used to treat skin infections in dogs susceptible to certain bacteria strains as well as bladder and respiratory infections. It is also used to treat skin and soft tissue infections in cats. It is a cephalosporin antibiotic that treats bacterial infections by suppressing the growth of micro-organisms such as bacteria, fungi, or protozoa.

Cautions:

Contact your veterinarian in the event of an allergic reaction (such as, shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, mucous or blood in the stool, unusual bleeding, or bruising). Also, do not give to animals who are hypersensitive to penicillin or cephalosporin.

Brand Name:

Vantin

Active ingredients:

Cefpodoxime proxetil

What is the most important thing I should know about cefpodoxime proxetil?

Cefpodoxime proxetil treats a range of infections, including those of the skin, bladder and respiratory system. Cefpodoxime proxetil requires a prescription from a veterinarian. The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. Safety for cats that are breeding, pregnant, or lactating also has not been demonstrated due to a lack of adequate studies. It may be used, however, if the prescribing veterinarian feels that the benefits outweigh the risks involved. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs’ test. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillin and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.

What should I discuss with my veterinarian before giving cefpodoxime proxetil to my pet?

Tell your veterinarian if your pet is on aminoglycosides (gentamicin or neomycin), blood thinners, or probenicid.

How this product should cefpodoxime proxetil be given?

Cefpodoxime proxetil is an oral antibiotic. Follow the directions given by your veterinarian. Keep plenty of water available for your pet to drink. Give all the medication prescribed even if your pet seems to be fully recovered.

What are the potential side effects of cefpodoxime proxetil?

Stop administering and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur. Continue to give cefpodoxime proxetil and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What happens if I miss giving a dose of cefpodoxime proxetil?

Give the dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and give the next regularly scheduled dose. Do not give your pet a double dose.

What happens if I overdose my pet on cefpodoxime proxetil?

Call your veterinarian immediately or take your pet to an emergency clinic. Signs of overdose may include vomiting, diarrhea, and/or jaundice.

What should I avoid while giving cefpodoxime proxetil?

Do not administer at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.

What other drugs will affect cefpodoxime proxetil?

Consult your veterinarian if your pet is currently on any other medications, as drug interactions could occur. Use with caution if your pet is on aminoglycosides (gentamicin or neomycin), blood thinners, or probenicid.

CEFPODOXIME PROXETIL Side Effects, Adverse Reactions | Healthgrades

Clinical Trials:

Film-coated Tablets (Multiple dose):

In clinical trials using multiple doses of cefpodoxime proxetil film-coated tablets, 4696 patients were treated with the recommended dosages of cefpodoxime (100 to 400 mg Q 12 hours). There were no deaths or permanent disabilities thought related to drug toxicity. One-hundred twenty-nine (2.7%) patients discontinued medication due to adverse events thought possibly or probably related to drug toxicity. Ninety-three (52%) of the 178 patients who discontinued therapy (whether thought related to drug therapy or not) did so because of gastrointestinal disturbances, nausea, vomiting, or diarrhea. The percentage of cefpodoxime proxetil-treated patients who discontinued study drug because of adverse events was significantly greater at a dose of 800 mg daily than at a dose of 400 mg daily or at a dose of 200 mg daily. Adverse events thought possibly or probably related to cefpodoxime in multiple-dose clinical trials (N=4696 cefpodoxime-treated patients) were:

Incidence Greater Than 1%:

Diarrhea                                  7%

Diarrhea or loose stools were dose-related: decreasing from 10.4% of patients receiving 800 mg per day to 5.7% for those receiving 200 mg per day. Of patients with diarrhea, 10% had C. difficile organism or toxin in the stool. (See WARNINGS .)

Nausea                                    3.3%
Vaginal Fungal Infections     1%
Vulvovaginal Infections        1.3%
Abdominal Pain                     1.2%
Headache                               1%

Incidence Less Than 1%: By body system in decreasing order:

Clinical Studies

Adverse events thought possibly or probably related to cefpodoxime proxetil that occurred in less than 1% of patients (N=4696)

Body  – fungal infections, abdominal distention, malaise, fatigue, asthenia, fever, chest pain, back pain, chills, generalized pain, abnormal microbiological tests, moniliasis, abscess, allergic reaction, facial edema, bacterial infections, parasitic infections, localized edema, localized pain.

Cardiovascular  – congestive heart failure, migraine, palpitations, vasodilation, hematoma, hypertension, hypotension.

Digestive  – vomiting, dyspepsia, dry mouth, flatulence, decreased appetite, constipation, oral moniliasis, anorexia, eructation, gastritis, mouth ulcers, gastrointestinal disorders, rectal disorders, tongue disorders, tooth disorders, increased thirst, oral lesions, tenesmus, dry throat, toothache.

Hemic and Lymphatic  – anemia.

Metabolic and Nutritional  – dehydration, gout, peripheral edema, weight increase.

Musculo-skeletal  – myalgia.

Nervous  – dizziness, insomnia, somnolence, anxiety, shakiness, nervousness, cerebral infarction, change in dreams, impaired concentration, confusion, nightmares, paresthesia, vertigo.

Respiratory – asthma, cough, epistaxis, rhinitis, wheezing, bronchitis, dyspnea, pleural effusion, pneumonia, sinusitis.

Skin – urticaria, rash, pruritus non-application site, diaphoresis, maculopapular rash, fungal dermatitis, desquamation, dry skin non-application site, hair loss, vesiculobullous rash, sunburn. 

Special Senses  – taste alterations, eye irritation, taste loss, tinnitus. 

Urogenital  – hematuria, urinary tract infections, metrorrhagia, dysuria, urinary frequency, nocturia, penile infection, proteinuria, vaginal pain. 

Granules for Oral Suspension (Multiple dose): 

In clinical trials using multiple doses of cefpodoxime proxetil granules for oral suspension, 2128 pediatric patients (93% of whom were less than 12 years of age) were treated with the recommended dosages of cefpodoxime (10 mg/kg/day Q 24 hours or divided Q 12 hours to a maximum equivalent adult dose). There were no deaths or permanent disabilities in any of the patients in these studies. Twenty-four patients (1.1%) discontinued medication due to adverse events thought possibly or probably related to study drug. Primarily, these discontinuations were for gastrointestinal disturbances, usually diarrhea, vomiting, or rashes. 

Adverse events thought possibly or probably related, or of unknown relationship to cefpodoxime proxetil for oral suspension in multiple-dose clinical trials (N=2128 patients treated with cefpodoxime) were: 

Incidence Greater Than 1%:

Diarrhea                                              6% 

The incidence of diarrhea in infants and toddlers (age 1 month to 2 years) was 12.8%. 

Diaper rash/Fungal skin rash               2% (includes moniliasis)

The incidence of diaper rash in infants and toddlers was 8.5%. 

Other skin rashes                                 1.8%
Vomiting                                              2.3%

Incidence Less Than 1%:

Body: Localized abdominal pain, abdominal cramp, headache, monilia, generalized abdominal pain, asthenia, fever, fungal infection.

Digestive: Nausea, monilia, anorexia, dry mouth, stomatitis, pseudomembranous colitis.

Hemic & Lymphatic: Thrombocythemia, positive direct Coombs’ test, eosinophilia, leukocytosis, leukopenia, prolonged partial thromboplastin time, thrombocytopenic purpura.

Metabolic & Nutritional: Increased SGPT.

Musculo-Skeletal: Myalgia.

Nervous: Hallucination, hyperkinesia, nervousness, somnolence.

Respiratory: Epistaxis, rhinitis.

Skin: Skin moniliasis, urticaria, fungal dermatitis, acne, exfoliative dermatitis, maculopapular rash.

Special Senses: Taste perversion.

Film-coated Tablets (Single dose):

In clinical trials using a single dose of cefpodoxime proxetil film-coated tablets, 509 patients were treated with the recommended dosage of cefpodoxime (200 mg). There were no deaths or permanent disabilities thought related to drug toxicity in these studies.

Adverse events thought possibly or probably related to cefpodoxime in single-dose clinical trials conducted in the United States were: 

Incidence Greater Than 1%:

Nausea                                                1.4%
Diarrhea                                              1.2%

Incidence Less Than 1%:

Central Nervous System: Dizziness, headache, syncope.
Dermatologic : Rash.
Genital: Vaginitis.
Gastrointestinal: Abdominal pain.
Psychiatric: Anxiety.

Laboratory Changes

Significant laboratory changes that have been reported in adult and pediatric patients in clinical trials of cefpodoxime proxetil, without regard to drug relationship, were: 

Hepatic : Transient increases in AST (SGOT), ALT (SGPT), GGT, alkaline phosphatase, bilirubin, and LDH. 

Hematologic : Eosinophilia, leukocytosis, lymphocytosis, granulocytosis, basophilia, monocytosis, thrombocytosis, decreased hemoglobin, decreased hematocrit, leukopenia, neutropenia, lymphocytopenia, thrombocytopenia, thrombocythemia, positive Coombs’ test, and prolonged PT, and PTT. 

Serum Chemistry : Hyperglycemia, hypoglycemia, hypoalbuminemia, hypoproteinemia, hyperkalemia, and hyponatremia. 

Renal : Increases in BUN and creatinine. 

Most of these abnormalities were transient and not clinically significant. 

Post-marketing Experience:

The following serious adverse experiences have been reported: allergic reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and serum sickness-like reactions, pseudomembranous colitis, bloody diarrhea with abdominal pain, ulcerative colitis, rectorrhagia with hypotension, anaphylactic shock, acute liver injury, in utero exposure with miscarriage, purpuric nephritis, pulmonary infiltrate with eosinophilia, and eyelid dermatitis. 

One death was attributed to pseudomembranous colitis and disseminated intravascular coagulation. 

Cephalosporin Class Labeling: 

In addition to the adverse reactions listed above which have been observed in patients treated with cefpodoxime proxetil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics: 

Adverse Reactions and Abnormal Laboratory Tests : Renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, serum sickness-like reaction, hemorrhage, agranulocytosis, and pancytopenia.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. (See DOSAGE AND ADMINISTRATION and OVERDOSAGE . ) If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Cefpodoxime for Dogs | Great Pet Care

Cefpodoxime is a commonly-used antibiotic in veterinary medicine. It is effective against a wide variety of bacteria and can be used to treat infections in dogs. Cefpodoxime has the advantage of only requiring once-daily dosing, making it a convenient choice for many pet owners. 

Cefpodoxime, known by the brand name Simplicef, is most commonly used to treat bacterial skin infections. However, this antibiotic can also be used to treat a number of other bacterial infections. It has a low risk of side effects, making it a good option for many dogs. 

What is Cefpodoxime?

Cefpodoxime was initially patented in 1980, although it was not commercially available for use in human medicine until approximately 10 years later. In 2002, the veterinary drug Simplicef was released, providing a formulation of cefpodoxime that was labeled for use in canine patients. A veterinary generic version of cefpodoxime was introduced in 2013, making this drug more affordable and increasing its availability to a larger number of clients and patients.  

Cefpodoxime belongs to a class of antibiotics called 3rd-generation cephalosporins. The first cephalosporins (now referred to as 1st-generation cephalosporins) were developed in the 1960s, in order to overcome antibiotic resistance that bacteria had developed in response to penicillin. These cephalosporins worked similarly to penicillin, but were more effective against antibiotic-resistant bacteria. Although these early cephalosporins were a significant improvement over penicillin, bacteria continued to evolve and soon developed new methods of resistance. Therefore, 2nd-generation and 3rd-generation cephalosporins were introduced to offer a broader spectrum of activity against bacteria that may be resistant to other antibiotics.

Cefpodoxime is now widely used by small animal veterinarians. It is effective against a wide variety of bacterial infections and the convenience of once-daily dosing helps ensure that pets receive all recommended doses of their medication. 

Almost all veterinary clinics in the United States carry Simplicef or the generic formulation of cefpodoxime and prescribe it to their patients when appropriate.

What Does Cefpodoxime Look Like?

Cefpodoxime is most commonly administered as an oral tablet. Simplicef, the name brand formulation, comes as an orange, oval tablet that is scored down the center. Generic versions are also often oval shaped and may be orange or red in color, but appearance may vary depending upon the manufacturer.  

Cefpodoxime is also available in a suspension formulation, although this is less commonly used. Cefpodoxime suspension is supplied as a powder, which must be mixed with water.

How Does Cefpodoxime Work?

Cefpodoxime kills susceptible bacteria by damaging the cell wall. It is very resistant to breakdown by bacterial enzymes, which makes it effective in many cases where other antibiotics, such as penicillin or cephalexin, would not be effective.

What Does Cefpodoxime Treat in Dogs?

Cefpodoxime is used to treat a variety of infections in dogs and puppies over 18 days old. The most common use of cefpodoxime is the treatment of bacterial skin infections. However, cefpodoxime’s broad spectrum and ability to reach many areas of the body make it a good option to use for the treatment of a number of different infections.

Dog conditions that are commonly treated with cefpodoxime include: 

• Skin infection
• Urinary tract infection
• Upper respiratory infection (such as kennel cough)
• Middle ear infection 

Cefpodoxime

Side Effects in Dogs

Like any medication, cefpodoxime can cause side effects in dogs. Fortunately, these side effects are rare. A small percentage of dogs taking this medication will experience gastrointestinal upset. This effect can typically be minimized by giving cefpodoxime with a full meal. In very rare circumstances, dogs may experience an allergic reaction to cefpodoxime that may vary from mild to severe.

Cefpodoxime side effects for dogs may include: 

• Vomiting
• Diarrhea
• Decreased appetite
• Hives 
• Shortness of breath 
• Facial swelling

If your pet experiences significant side effects due to cefpodoxime, contact your veterinarian to determine the best course of action for your pet. 

Reactions With Other Drugs and Medications

Cefpodoxime should not be taken within two hours of giving your dog antacids, as the use of antacids may interfere with the body’s ability to absorb cefpodoxime. Additionally, cefpodoxime should not be given with a particular class of antibiotics known as aminoglycosides.

Cefpodoxime is safe to give with your dog’s monthly flea or heartworm prevention, as well as with most other medications. Talk to your veterinarian if you have any concerns.

Cefpodoxime

Dosages for Dogs

Cefpodoxime is administered once a day. Your veterinarian will determine the appropriate dose for your dog, depending upon your dog’s weight and the condition that requires treatment. 

It is important to give this medication as directed. Give all of the medication that is prescribed for your dog, even if his condition appears to have resolved. Stopping your pet’s antibiotic treatment early can lead to antibiotic-resistant infections.  

Cefpodoxime can be given with food or on an empty stomach. 

What if My Dog Misses a Dose of Cefpodoxime?

Like any antibiotic, cefpodoxime should be given on a regular schedule with no missed doses. Missing doses will decrease the efficacy of the medication.

If you do miss a scheduled dose of medication, you should give that dose as soon as possible and resume dosing your pet every 24 hours. 

For example, imagine that you forget your dog’s morning dose of cefpodoxime and do not realize your mistake until that evening. What should you do? Give the medication at that time, as soon as you realize that you missed a dose. In order to maintain an every-24-hour dosing schedule, you will need to give your dog his cefpodoxime in the evening until you have completed the entire course of medication.

If your pet misses more than one dose of medication, contact your veterinarian. Depending on the details of your situation, you may be instructed to resume the medication or your veterinarian may elect to change your pet to a different medication.  

Cost of Cefpodoxime for Dogs

The price of cefpodoxime can vary significantly, depending on your dog’s size and the duration of therapy that is required. A one-week course of cefpodoxime for a small dog may cost as little as $20-$30, while a prolonged course of cefpodoxime for a large-breed dog may cost $150 or more. 

In general, the generic version of cefpodoxime is less expensive than the name brand Simplicef. 

Cefpodoxime

Storage Instructions

Cefpodoxime is typically dispensed as a tablet. This tablet can be stored at room temperature, in a cabinet or on your counter.

Cefpodoxime suspension is less commonly used in veterinary medicine. If your pet is prescribed cefpodoxime suspension, however, this medication must be stored in the refrigerator. Any unused pre-mixed cefpodoxime must be thrown away after two weeks, because the suspension form of this medication is only stable for 14 days after mixing. 

Cefpodoxime – tabletwise.net

Your dose and how often you take Cefpodoxime will depend on the following factors:

• age
• weight
• patient’s health
• the health of the patient’s liver
• medicines recommended by the doctor
• any other medicines being used

Cefpodoxime Dosage

Dosage for throat infection

Adult (children and adults aged 12 years and older)

• Recommended: 100 mg every 12 hours for 5 to 10 days for tablets and granules for oral suspension (200 mg daily)

Children (2 months to 12 years)

• Recommended: 5 mg/kg/dose (2.3 mg/lb/dose) every 12 hours for 5 to 10 days (granules for oral suspension)
• Maximum: 100 mg/dose

Children (infants and children aged 1 month – 11 years and body weight 5 kg (11.02lb))

• Recommended: 20 mg/2.5 ml (half teaspoon) twice daily of 40 mg/5 ml granules for oral suspension

Children (infants and children aged 1 month – 11 years and body weight 10 kg (22.04lb))

• Recommended: 40 mg/5 ml (full teaspoon) twice daily of 40 mg/5 ml granules for suspension

Children (infants and children aged 1 month – 11 years and body weight 15 kg (33.1 lb))

• Recommended: 60 mg/7.5 ml (half tablespoon) twice daily of 40 mg/5 ml granules for suspension

Children (infants and children aged 1 month – 11 years and body weight 20 kg (44.1 lb))

• Recommended: 80 mg/10 ml (2 teaspoons) twice daily of 40 mg/5 ml granules for suspension

Children (infants and children aged 1 month – 11 years and body weight 25 kg (55.12 lb))

• Recommended: 100 mg/12.5 ml (two and a half teaspoon) twice daily of 40 mg/5 ml granules for suspension

Dosage for acute community-acquired pneumonia

Adult (children and adults aged 12 years and older)

• Recommended: 200 mg every 12 hours for 14 days for tablets and granules for oral suspension (400 mg daily)

Dosage for long-term inflammation of the lungs (long-terms bronchitis)

Adult (children and adults aged 12 years and older)

• Recommended: 200 mg every 12 hours for 10 days for tablets (400 mg daily)

Dosage for uncomplicated gonorrhea

Adult (children and adults aged 12 years and older)

• Recommended: 200 mg once daily for tablets and granules for oral suspension

Dosage for skin and skin structure infection

Adult (children and adults aged 12 years and older)

• Recommended: 400 mg every 12 hours for 7 to 14 days for tablets and granules for oral suspension (800 mg daily)

Dosage for the sinus infection

Adult (children and adults aged 12 years and older)

• Recommended: 200 mg every 12 hours for 10 days for tablets and granules for oral suspension (400 mg daily)

Children (2 months to 12 years)

• Recommended: 5 mg/kg (2.3 mg/lb) every 12 hours for 10 days granules for oral suspension
• Maximum: 200 mg/dose

Dosage for urinary tract infection

Adult (children and adults aged 12 years and older)

• Recommended: 100 mg every 12 hours for 7 days for tablets and granules for oral suspension (200 mg daily)

Dosage for the middle ear infection

Children (2 months to 12 years)

• Recommended: 5 mg/kg (2.3 mg/lb) every 12 hours for 5 days granules for oral suspension
• Maximum: 200 mg/dose

Dosage for rectal infection in women

Adult (children and adults aged 12 years and older)

• Recommended: 200 mg once daily for tablets and granules for oral suspension

Minimum Age

1 month

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet

Strength: 100 mg, 200 mg

Granules for oral suspension (50 mg/5 ml and 100 mg/5 ml)

Strength: 100 ml, 75 ml, 50 ml

Special Instructions

Patients with kidney dysfunction

This medicine does not require dose modification in patients with creatinine clearance more than 40ml/min. The dosing intervals should be increased to four times in 24 hours if the creatinine clearance is less than 30 ml/min. If the patient is maintained on artificial blood purifying technique called hemodialysis, then the dosing interval should be three times per week after therapy. If the creatinine clearance is less than 10 ml/min., a single dose should be given in every 48 hours.

50 ml oral suspension (50 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 29 ml of purified water is used to prepare the oral suspension.

75 ml oral suspension (50 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 44 ml of purified water is used to prepare the oral suspension.

100 ml oral suspension (50 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 58 ml of purified water is used to prepare the oral suspension.

50 ml oral suspension (100 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 29 ml of purified water is used to prepare the oral suspension.

75 ml oral suspension (100 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 43 ml of purified water is used to prepare the oral suspension.

100 ml oral suspension (100 mg/5 ml)

Shake the bottle to release the granules. Then add water in two equal portions, with vigrous shaking after adding each fraction of water. A total of 57 ml of purified water is used to prepare the oral suspension.

Missed Dose

The missed dose of Cefpodoxime should be taken immediately when you remember it, skip the dose if its almost time for the next dose. Then continue with the regular schedule. Do not take a double dose to make up the missed dose.

Overdose

What to do if you overdose on Cefpodoxime?

If this happens, the supportive measures and treatment for symptoms should be provided. The artificial blood purifying techniques should be used to remove the excessive level of Cefpodoxime from the body.

Symptoms of an overdose of Cefpodoxime

If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:

If you think you have overdosed on Cefpodoxime, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Cefpodoxime for Dogs Guide: How it Works [Dosage & Side Effects]

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Dog skin infection is a common health problem for our furry pals. Skin infection can drive dogs crazy, the sight of a scratching dog can make every caring owner miserable. One of the major reasons owners take their dogs to the vet is to seek relief from these infections.

What makes it worse is that antibiotics that have long been an important part of treating skin infections are losing the fight against drug-resistant bacteria. Especially staph strains bacteria commonly associated with canine skin infections. Cefpodoxime for dogs is a 3rd generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms.

If you find yourself in this situation, read on as we reveal the ideal medication that will solve your dog’s skin problem and bring her skin back to normal. The good news is that cefpodoxime is a very effective antibiotic that can be used to treat canine skin infections. It is effective against a wide range of bacteria. In this article, we will discuss everything you need to know about cefpodoxime for dogs. So read on and find out if cefpodoxime is a suitable option for your dog’s skin infection.

1. Chewy CefpodoximeProxetil (Generic) Tablets for Dogs-
2. Cefpoderm Tablets for dogs
3. Simplicef (CefpodoximeProxetil) Tablets for Dogs (100mg)
4. Walmart Cefpoderm Tablet for Dogs
5. Walmart Simplicef Tablet for dogs
6. Cefpodoxime Tabs 200 mg, 100 Tablets

What is cefpodoxime for dogs?

Cefpodoxime is an antibiotic used to treat skin infections in dogs. Cefpodoxime is a third-generation cephalosporin antibiotic used to treat a wide variety of bacterial infections in dogs. Veterinarians may recommend cefpodoxime to dogs suffering from bacterial infections. Cefpodoxime is effective in the treatment of bacterial infections such as wounds and open sores caused by susceptible organisms. Not viral infections such as the flu or colds.

What does cefpodoxime for dogs look like?

Cefpodoxime is usually administered as an oral pill. Simplicef, the brand name, comes in the form of an orange egg-shaped tablet that is marked in the center. Common versions are also usually elliptical in shape and can be red or orange in color, although the appearance may differ by manufacturer. Cefpodoxime is also obtainable in a suspension formulation, though this is not common. Cefpodoxime suspension is available as a powder, which must be mixed with water.

How does cefpodoxime for dogs work?

Cefpodoxime is the active substance in a drug refers to as cefpodoxime proxetil. This antibiotic is administered to dogs orally, in tablet form. If your furry pal has a skin infection caused by bacteria like Staphylococcus intermedius, Staphylococcus aureus, or Proteus mirabilis, etc. A vet may prescribe cefpodoxime proxetil, this antibiotic works by preventing bacteria from creating enough cell walls, which in turn destroys them. Cefodoxyproxetil has a lot in common with cephalexin, which is another commonly used antibiotic in dogs.

What are the infections treated with cefpodoxime?

Cefpodoxime is commonly used to treat different kinds of skin infections in dogs and puppies older than 18 days. It can also be used to treat respiratory and urinary tract infections. The United States Food and Drug Administration (FDA) has approved the use of products containing Cefpodoxime in dogs. The body authorizes veterinarians to recommend and use products containing Cefpodoxime in different species of dogs. Cefpodoxime’s ability to reach different areas of the body makes it a good choice for treating various infections. The following are dog conditions commonly treated with cefpodoxime include:

• Ear infection
• Skin infection
• An upper respiratory infection
• Urinary tract infection

Is cefpodoxime a strong antibiotic?

Cefpodoxime is a third-generation antibiotic known as cephalosporins. The first generation of cephalosporins was developed around the 1960s, to overcome the antibiotic resistance that microorganisms had developed in reaction to medication like penicillin. Cephalosporins worked just like penicillins but were very active against antibiotic-resistant bacteria. Though these first cephalosporins were a major improvement over penicillins, bacteria continued to advance and soon developed new means of resistance. So, the second and third-generation cephalosporins were developed to provide a broader spectrum of activity against bacteria that may resist other antibiotics.

How long does it take for cefpodoxime to work in dogs?

Cefpodoxime eliminates sensitive bacteria by attacking the cell wall. It is extremely resistant to attack by bacterial enzymes, this makes it effective in several conditions where other antibiotics are not effective. The medication should start working within 1 to 2 hours, although you may not see the effects of this drug externally. Your furry pal should start recovering in a day or two. The effects of this drug are short-lived, meaning that it will stop working within 24 hours, though the benefits may be prolonged if your dog has decreased kidney. ()

What are the side effects of cefpodoxime for dogs?

Cefpodoxime proxetil for dogs is just like most other medications out there, has the potential to cause side effects. Some dogs vomit shortly after taking cefpodoxime proxetil. Dogs may also experience diarrhea, decreased appetite, shortness of breath, and facial swelling as the side effect of taking cefpodoxime. Tiredness is also a possibility. If you are breeding your dog, already pregnant or presently nursing puppies, discuss with your vet about any potential problems these conditions could introduce. Inform your veterinarian if your dog is using other medications or ever experienced any problems with any cephalosporin or penicillin medications. Dogs allergic to cefpodoxime should not take it. Consult your veterinarian immediately if you have any questions about cefpodoxime’s side effects on your dog.

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If your dog experiences significant side effects from cefpodoxime, get in touch with your veterinarian to determine the best course of action for your furry pal. If the side effect is severe, or you suspect an allergic reaction or overdose, make sure you contact your vet immediately, as it could be an emergency situation. You can also consult the Pet Poison Helpline and the ASPCA’s Animal Poison Control Center if you suspect that your dog has overdosed on the medication.

Like with other medication, for example, trazodone-for-dogs, always follow the guidelines and look for any side effects.

Cefpodoxime Dosages for Dogs

CefpodoximeProxetil is a prescription for dogs to treat bacterial skin infections, wounds, and abscesses, including bladder and respiratory infections. This drug can easily be hidden in your dog’s favorite food since it comes in an uncoated tablet form. cefpodoxime dosage for dogs is once a day. Your vet will decide the right dose for your pup, depending upon your puppy’s weight and the condition that requires treatment. It is important to give this medication as directed.

Administer the entire drug that is recommended for your dog, even when his condition appears to have resolved. Discontinuing your dog antibiotic treatment quickly can lead to antibiotic-resistant infections. Cefpodoxime can be given with food or on an empty stomach.

Cefpodoxime proxetil tablets should be given once a day for five to seven days or for two to three days after the cessation of clinical symptoms, up to a maximum of 28 days. Treatment of severe infections should not be continued for more than three to four days if there is no response to treatment. The following table offers guidelines for daily dosing of cefpodoxime. Make sure you follow all of your vet’s instructions.

Cefpodoxime for dogs Tablets at 2.3 mg/lb Total Daily Dosage

 Cefpodoxime Tabs at 4.5 mg/lb Total Daily Dosage

The major benefits of cefpodoxime for dogs

Compared to other products, cefpodoxime is a commonly used antibiotic in veterinary medicine, if you are wondering. The following are some of the major benefits of Cefpodoxime proxetil for dogs:

• It is effective against a wide variety of bacteria and can be used to treat infections in dogs.
• Cefpodoxime can be administered to both dogs and cats
• Cefpodoxime takes a long time to break down in the body. This means that for most dogs, one pill a day is enough.
• The tablets are scored, coated, and odorless. This means that most dogs will easily eat them.
• Unlike many other antibiotics, cefpodoxime can be given with or without food.

Prevention is always better than trying to fix the problem. When you groom your dog look for potential skin problems and deal with potential issues as soon as you can.

Cefpodoxime for dogs: available products

Now that you have a good understanding of this medication and you now feel more confident that Cefodoxime could be an excellent choice for your dog’s skin infection. It is best to consult your veterinarian before using cefpodoxime to treat a dog infection problem. The following are the in-depth reviews on the best cefpodoxime products along with their pros and cons. If you know what you need, here are the quick links to the products.

1. Chewy CefpodoximeProxetil (Generic) Tablets for Dogs

Cefpodoximeproxetil tablets are used for the treatment of bacterial skin infections. Including wounds and abscesses, as well as bladder and respiratory infection in dogs. It comes in an uncoated tablet form and can be easily concealed in your dog’s favorite food for easy administration. The following are the pros and cons of cefpodoxime proxetil for dogs.

Pros

• It has an excellent price tag
• It’s easy to hide in your dog’s favorite food.
• It is also used in the treatment of bladder and respiratory infections in dogs.
• It treats bacterial infections by suppressing the growth of microorganisms.

Cons

• It is not suitable for dogs allergic to cephalosporins or penicillins.

2. Cefpoderm Tablets for dogs

Cefpoderm tablet is an oral drug used to treat dog skin infections caused by susceptible strains of Staphylococcus aureus, Escherichia coli, Streptococcus canis, Pasteurella multocida, and Staphylococcus intermedius. If your furry pal has a skin infection, wound, or abscess, your veterinarian may recommend Cefpoderm tablets to treat your dog’s skin infection. Cefpoderm Tablets are easy to administer to your dog and should only be given once a day.

This tablet can also help treat respiratory and bladder infections in dogs. Helping them to quickly recover to their normal, happy, and healthy self. The following are the pros and cons of Cefpoderm tablets for dogs.

Pros

• It treats skin, respiratory, and bladder infections in dogs.
• It can be administered with or without food
• It helps dogs to quickly return back to their normal self
• Simple oral once-daily dosing
• It comes in a film-coated tablet for easy administration.

Cons

• It is not suitable for pregnant or nursing dogs.

3. Simplicef (Cefpodoxime Proxetil) Tablets for Dogs (100mg)

Cefpodoxime 100mg tablets for dogs are used to treat various infections in dogs caused by both Gram-positive and Gram-negative bacteria. These infections include urinary tract, skin, bone, and respiratory tract infections. The good thing about this antimicrobial is that it comes in a tablet shape, therefore you can feed it orally. The following are the pros and cons of Simplicef tablets for dogs.

Pros

• It is used to treats several kinds of infections with mild side effects.
• It is taken two times a day, compared to some of the more frequently taken alternatives.
• cefpodoxime 100mg for dogs is available in a tablet and liquid form
• Since it comes in tablet form, you can feed your dog orally.
• It is ideal for treating skin infections such as wounds and abscesses in dogs.

Cons

• It is not suitable for pregnant or lactating dogs.
• Not good for dogs with seizure disorders, epilepsy, and kidney disease.

4. Walmart Cefpoderm Tablet for Dogs

CefpodoximeProxetil is an antibiotic tablet that helps in treating dog skin infections. It is also effective in treating respiratory and bladder infections in dogs. CefpodoximeProxetil is easy to administer on a once-daily, oral tablet. The following are the pros and cons of the Cefpoderm Tablet for Dogs.

Pros

• FDA approved for the treatment of bacterial skin infections in dogs
• Simple doses once a day
• It can be taken with or without food.

Cons

• It can cause allergic reactions in sensitized dogs

5. Walmart Simplicef Tablet for dogs

SIMPLICEF is the first once-a-day oral cephalosporin that has been approved by the FDA for vet. To use in the treatment of dog skin infections caused by susceptible strains of Streptococcus aureus, Pasteurella multocida, Escherichia coli, and Proteus mirabilis. It is made to be convenient and of good value for dogs. The following are the pros and cons of Simplicef tablets for dogs.

Pros

• It can also be used in treating other types of infections, such as ear and urinary tract infections in dogs.
• It is also effective in treating respiratory tract infection
• It is designed to be convenient when giving your dogs.
• This is the first oral once-daily cephalosporin that has been approved by the FDA for veterinary use in the treatment of dog skin infections.

Cons

• It can cause poor appetite in some dogs.

6. Cefpodoxime Tabs 200 mg, 100 Tablets

cefpodoxime 200 mg for dogs is a cephalosporin antibiotic approved by the FDA to treat skin infections such as wounds and abscesses in dogs. This particular drug is the generic equivalent of Simplicef 200mg tablets. Since cefpodoxime is less expensive than Simplicef. You can save more while continuing to treat your dog’s infection. These tablets are effective against strains of Staphylococcus aureus, Streptococcus canis, Pasteurellamultocida, Escherichia coli, and Proteus Proteus. cefpodoxime 200 mg for dogs is effective in treating bacterial infections in dogs.

Pros

• It is excellent antibiotics for dogs
• It treats a variety of infections, such as skin, urinary tract, respiratory infections in dogs.
• It is an easy medication regimen for dogs
• It can be given with or without food

Cons

• The safety of this drug is not confirmed for breeding, pregnant, or lactating dogs.

FAQ’s About Cefpoderm for dogs

Explore the questions below to learn the basics of Cefpodoxime, its use, and the possible side effects. Cefpodoxime is essential to combat canine skin infections. This is the most effective way to treat a bacterial infection in dogs. These Frequently Asked Questions (FAQs) remove some confusion and provide you with science-based information to help you make informed decisions about cefpodoxime for dogs.

Can humans take cefpodoxime?

Cefpodoxime is accepted to treat bacterial infections in humans. You may be familiar with this medication because your furry pal got it from a veterinarian. Do not take cefpodoxime unless your healthcare provider recommends it for you. Human and pet medications are not always made the same, therefore a dog’s supply of cefpodoxime may not be suitable for a human, and your cefpodoxime supply may not be suitable for your dog.

How should I store cefpodoxime?

The safety storage of cefpodoxime proxetil is something every dog owner should be aware of. Knowing how to safely store your medications is an essential part of treatment. Although cefpodoxime is designed to treat infections, it can cause great harm. A few simple safety measures can help protect your furry pals. Store cefpodoxime proxetil tablets away from heat and light between 68 ° F and 77 ° F (20-25 ° C). Liquid suspensions should be cooled between 35°F and 45°F (2°C-8°C) for up to 2 weeks.

What if I miss giving my pet the medication?

Life gets busy and we often forget to take our medicines, not to mention giving our dogs their daily dosage. Missing your dog’s medication can have serious consequences depending on the treatment for your dog. If you skip a dose, give it once you remember. But if it is time for the next dose, forget the missed dose and give it at the next scheduled time and continue your usual dosing plan. Do not give your dog more than one dose at a time or provide extra doses.

Which is better amoxicillin or cefpodoxime?

Cefpodoxime and amoxicillin are different kinds of antibiotics. Cefpodoxime is a cephalosporin antibiotic and amoxicillin is a penicillin-type antibiotic. Cefpodoxime has been shown to be better than amoxicillin in treating severe skin infections in dogs. Cefpodoxime produces a much superior clinical treatment rate than amoxicillin. Cefpodoxime is used to treat bacterial infections in different parts of the body. It belongs to the class of medication known as cephalosporin antibiotics.

What should I do in an emergency situation?

If you think that your furry pal is experiencing an adverse reaction due to cefpodoxime proxetil, or has overdosed. Contact your veterinarian or emergency veterinary hospital without delay. Signs of a cefpodoxime overdose include diarrhea, vomiting, jaundice; it can also lead to decrease appetite and lethargy.

Are there any risk factors for this medication?

Cefpodoxime is not recommended for dogs that are allergic to it or to other cephalosporins. It should be used with care in dogs with a history of seizures or kidney disease. Cefpodoxime should only be used during pregnancy with vet recommendations if necessary and should be used with carefulness in lactating dogs.

Are there any drug interactions I should be aware of?

If your veterinarian has directed you to use cefpodoxime. Your veterinarian may already be aware of any potential drug interactions and can monitor your dog for them. Do not start, stop, or change the dose of any cefpodoxime without first checking with your veterinarian. Cefpodoxime has no known serious interactions with other drugs. Although, some medications interact with cefpodoxime and reduce its absorption, so it is important to inform your vet of any medications (including supplements, vitamins, or herbal remedies) that your furry pal is taking.

Do not give Cefpodoxime at the same time as you are giving antacids like Maalox or other stomach acid reducers to your dog, as this can reduce the absorption and effectiveness of the medication. Keep a list of all the drugs your dog is taking and share this information with your veterinarian. Consult with your vet for other medical advice.

Any special considerations when giving cefpodoxime to dogs?

Despite the fact that cefpodoxime has been tested for safety in young puppies. Not enough studies have been conducted to confirm its safe use in breeding, pregnant, and lactating dogs. And it should only be used when necessary. Also, don’t administer cefpodoxime to dogs who are sensitive or allergic to penicillins, or other cephalosporins. Cefpodoxime should be used with care in dogs with seizure disorders or kidney disease.

Now that you have a thorough understanding of how this medication can help resolve your dog’s skin infection. You are ready to get Cefpodoxime for your dog. It is important to know that choosing the best product is a matter of evaluating your dog’s condition.

The next thing is to check with your vet. Your vet might consider a number of factors such as the severity of your dog’s skin infection symptoms, your dog’s medical history. Including any allergies and antibiotics, he has recently taken, and possibly perform a urinalysis to find out the kind of bacteria causing the infection.

With all this information, your vet will recommend the right cefpodoxime that is safe for your furry pal and will help eliminate the problem. Cefpodoxime is safe and effective in treating canine skin infections. The once-daily dosage makes cefpodoxime a very convenient antibiotic for dog owners and also helps increase compliance. Treating the underlying factors and following the appropriate dose and duration of the antibiotic will prevent the recurrence of the disease.

Always make sure your dog has a safe and calm place to rest they have a medical problem. For example, use a dog-proof trash can to avoid your dog getting infected by harmful bacteria in your trash.

Author: Terry Wildog – Dr. Terry is a professional veterinarian with 10 years of medical experience. He currently splits his time between part-time vet practice and writing educational material for pet parents. A passionate animal lover and expert content writer. He spent his whole life with pets, especially dogs.

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Images Canva and Pexels

Active substance CEFPODOXIMUM | Directory of medicines Compendium

Release form: p / o tablets, powder for oral suspension.

Medicinal preparations containing the active substance CEFPODOXIM

other beta-lactam antibiotics

other beta-lactam antibiotics

other beta-lactam antibiotics

other beta-lactam antibiotics

other beta-lactam antibiotics

Semisynthetic antibiotic of the third generation cephalosporin group of a broad spectrum of action for oral administration.The bactericidal effect of cefpodoxime is due to the suppression of the synthesis of the outer membrane of bacteria. It is active against many gram-positive, gram-negative, aerobic and anaerobic microorganisms. Resistant to the action of β-lactamases of many microorganisms. Insensitive to cefpodoxime Streptococcus spp. Group D; Staphylococcus spp. methicillin resistant; Corynebacterium Groups J and K; Pseudomonas spp. , including Pseudomonas aeruginosa ; Listeria monocytogenes, Acinetobacter baumanii, Clostridium difficile and Bacteroides spp .

Penetrates well into lung tissue, bronchial mucosa, pleural fluid, palatine tonsils and interstitial fluid. It is excreted mainly in the urine unchanged.

infectious and inflammatory diseases of the ENT organs, upper and lower respiratory tract in adults and adolescents caused by microorganisms sensitive to cefpodoxime, including tonsillitis, pharyngitis, acute sinusitis, acute bronchitis, acute pneumonia, exacerbation of chronic bronchitis (especially in persons who abuse alcohol and smoking, and in persons over the age of 65).

dose is set individually. The daily dose for adults and adolescents is 200-400 mg. Assign inside during meals 2 times a day (every 12 hours). In patients with severe renal impairment (creatinine clearance <40 ml / min), a single dose is halved.

Hypersensitivity to cephalosporins.

diarrhea, nausea, vomiting, abdominal pain, transient moderate increase in the activity of transaminases and alkaline phosphatase in the blood plasma, a slight increase in the level of urea and creatinine in the blood plasma, thrombocytosis, thrombocytopenia, leukopenia and eosinophilia, headache, transient skin rash, itching.

is prescribed with caution to patients with hypersensitivity to penicillins. The safety of using cefpodoxime during pregnancy and lactation has not been established. During treatment, a positive Coombs reaction may appear.

blockers H ₂ -histamine receptors (ranitidine, etc.) and antacids (aluminum hydroxide, sodium bicarbonate) reduce the bioavailability of cefpodoxime.

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ^® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

What is this drug used for?

• Used to treat various types of bacterial infections.

What do I need to tell my doctor BEFORE taking this drug?

• If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.

This drug can be adversely affected when used with certain medicines and medical conditions.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural products and vitamins) and your health problems. You need to make sure that this drug is safe for your medical condition and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

• Tell all healthcare providers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• With long-term use of the drug, a blood test must be performed. Talk to a medical professional.
• This drug may interfere with some laboratory tests. Tell all healthcare providers and lab staff that you are taking this drug.
• Do not use for longer than the prescribed time. A secondary infection is possible.
• If you are allergic to tartrazine (FD&C Yellow No. 5), consult your doctor. Some products contain tartrazine.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can cause serious and sometimes deadly side effects. Call your doctor or doctor right away if you have any of the following signs or symptoms, which may be associated with serious side effects:

• Signs of an allergic reaction such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
• Convulsions.
• Diarrhea is common with antibiotics. In rare cases, severe diarrhea caused by the bacteria Clostridium difficile (C. diff.) [CDAD] can occur. This sometimes leads to gut problems that end in death. CDAD can occur during or several months after taking antibiotics. If you have pain, abdominal cramps, or very loose, watery or bloody stools, see your doctor right away. Check with your doctor before treating diarrhea.

What are some other side effects of this drug?

Any medicine can have side effects. However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor.Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you.Follow all instructions strictly.

Pills:

• Take with food.

Liquid (suspension):

• Take with or without food. Take with food if the medicine causes nausea.
• Shake well before use.
• Care should be taken to measure liquid doses. Use the dispenser that comes with the medicine. If a dispenser is not included in the package, ask your pharmacist for a dosing product for this drug.

All forms of issue:

• Continue taking this drug as directed by your doctor or other healthcare professional, even if you feel well.
• Antacids may need to be rescheduled for a different time than when this drug was taken. Ask your doctor or pharmacist for advice.

What should I do if a dose of a drug is missed?

• Take the missed dose as soon as you can.
• If it’s time to take your next dose, do not take the missed dose and then return to your normal dose schedule.
• Do not take 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

Pills:

• Store at room temperature in a dry place. Do not store in the bathroom.

Liquid (suspension):

• Store in refrigerator.Throw away any unused portion after 2 weeks.
• The lid must be tightly closed.

All forms of issue:

• Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into toilet or drain unless directed to do so.If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

General information on medicinal products

• If your health does not improve or even worsens, see your doctor.
• You should not give your medicine to anyone and take other people’s medicines.
• Some medicines may come with other patient information sheets.If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Use of information by consumer and limitation of liability

This information should not be used to make decisions about taking this or any other drug.Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are appropriate for a particular patient. This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient. Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug.This information should not be construed as a guide to treatment and does not replace the information provided to you by your healthcare professional. For complete information on the possible risks and benefits of taking this drug, consult your doctor. Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Copyright

© UpToDate, Inc.and its affiliates and / or licensors, 2021. All rights reserved.

instructions for use, analogs, composition, indications

Cefpodoxime, like other cephalosporins, should be used with caution in patients receiving concurrent treatment with strong diuretics.

Changes in renal function have been found with the use of cephalosporin antibiotics, especially when used simultaneously with potentially nephrotoxic drugs such as aminoglycosides and / or strong diuretics.In such cases, kidney function should be monitored.

As with other antibiotics, long-term use of cefpodoxime can lead to overgrowth of insensitive microorganisms (including fungi and Clostridium difficile), which may require interruption of treatment. Reassessment of the patient’s condition is essential. If superinfection occurs during therapy, appropriate measures must be taken.

Cefpodoxime is not the antibiotic of choice for the treatment of staphylococcal pneumonia and should not be used for the treatment of SARS caused by organisms such as Legionella, Mycoplasma and Chlamydia.

Cefpodoxime should always be used with caution in patients with gastrointestinal diseases, especially a history of colitis.

As with all beta-lactam antibiotics, neutropenia and, more rarely, agranulocytosis may develop, especially with long-term treatment. In cases where treatment lasts more than 10 days, blood tests should be monitored and treatment discontinued if neutropenia occurs.

Cephalosporins can be absorbed on the surface of erythrocyte membranes and react with antibodies directed against the drug.This can lead to positive Coombs’ tests and, very rarely, hemolytic anemia. Cross-reactivity with penicillin for this reaction may occur.

Before starting therapy with cefpodoxime proxetil, the patient should be carefully asked about the history of hypersensitivity reactions to cefpodoxime, other cephalosporins, penicillins, or other drugs.

Cefpodoxime is recommended to be used with caution in patients with allergic diseases (for example, hay fever or bronchial asthma), since in these cases the risk of severe hypersensitivity reactions increases, as well as in patients with mild hypersensitivity to penicillins, as cases of cross-hypersensitivity among beta lactam antibiotics.

Cases of antibiotic-associated and pseudomembranous colitis have been reported with almost all antibacterial agents, including cefpodoxime; the severity of the disease can range from mild to life-threatening. Therefore, a correct diagnosis is required in patients with diarrhea after taking antibacterial agents.

1 Sefpotec tablet contains less than 1 mmol (23 mg) sodium – this means that the tablets are practically “sodium-free”.

Interactions with other medicinal products, other forms interactions

Antacids: Concomitant administration of high doses of antacids (sodium bicarbonate, aluminum hydroxide) or H2 blockers may reduce plasma levels and the degree of absorption of cefpodoxime proxetil.

H2-histamine receptor blockers and antacids reduce the bioavailability of cefpodoxime. Studies have shown that bioavailability is reduced by about 30% when cefpodoxime is administered with drugs that neutralize gastric pH or inhibit acid secretion.Therefore, drugs such as mineral-type antacids and H2 blockers such as ranitidine, which can increase the pH in the stomach, should be taken 2-3 hours after taking cefpodoxime.

Concomitant oral administration of anticholinergic drugs slows down the time to peak concentration (Tmax), but does not affect the degree of absorption (AUC) of cefpodoxime proxetil.

Probenecid: probenecid slows down the renal excretion of cefpodoxime proxetil, reduces the excretion of cephalosporins, like other beta-lactam antibiotics, which leads to an increase in AUC and peak plasma levels of the drug.

Nephrotoxic drugs: Although nephrotoxicity has not been established with monotherapy with cefpodoxime proxetil, careful monitoring of renal function is required while taking cefpodoxime proxetil with other drugs with known nephrotoxic potential.

Interaction with laboratory tests :

A false positive urinary glucose reaction can occur with Fehling’s or Benedict’s solutions or copper sulfate tablets, but not with tests based on enzymatic reactions for glucose oxidase.

Cephalosporins increase the anticoagulant effect of coumarins and reduce the contraceptive effect of estrogens.

Oral anticoagulants:

The simultaneous administration of cefpodoxime with warfarin can lead to an increase in its anticoagulant effect. There are many reports of an increase in the activity of oral anticoagulants in patients receiving antibacterial agents, including cephalosporins. The risk may vary depending on the type of infection, age and general condition of the patient, so the contribution of cephalosporins to the increase in INR (international normalized ratio) is difficult to assess.

It is recommended to frequently monitor INR during and immediately after co-administration of cefpodoxime with oral anticoagulants.

Pregnancy and lactation period

The safety of the drug during pregnancy and lactation has not been established. Sefpotec can be used in pregnant women only if absolutely necessary. Cefpodoxime is excreted in mother’s milk. If it is necessary to use the drug Sefpotec in the mother, it is necessary to decide on the termination of breastfeeding.

Influence on the ability to drive vehicles and other mechanisms

During treatment with cefpodoxime, dizziness may occur, which may affect the ability to drive vehicles and other mechanisms.

Adverse reactions

Adverse reactions characteristic of the class of cephalosporins: renal dysfunction, toxic nephropathy, liver dysfunctions, including cholestasis, aplastic anemia, bleeding, agranulocytosis and pancytopenia, convulsions (especially in patients with renal failure in the absence of dosage adjustment).

Allergic reactions: anaphylactic reactions, bronchospasm, angioedema.

From the side of the central nervous system, of the peripheral nervous system of the system and sensory organs: anxiety, nervousness, impaired concentration, increased fatigue, confusion, sleep disturbances, drowsiness, insomnia, dizziness, headaches, changes or loss of taste, irritation eyes, ringing in the ears, paresthesias, cerebral infarction.

From the genitourinary system: acute renal failure, hematuria, metrorrhagia, dysuria, nocturia, proteinuria, frequent urination, urinary tract infections, vaginal pain, menstrual irregularities.

From the liver: liver dysfunctions.

From the digestive system: dry mouth, thirst, belching, nausea, vomiting, abdominal pain, flatulence, stool retention, persistent diarrhea, dysbiosis (Clostridium difficile growth), loss of appetite, gastritis, ulcerative colitis, oral ulcers , disorders of the rectum, pain in the teeth, tenesmus.

From the side of metabolism and nutrition: dehydration, weight gain, gout, peripheral edema, hyperkalemia, hyponatremia.

Respiratory system: cough, shortness of breath, bronchial asthma, bronchitis, pleurisy, pneumonia, rhinitis, sinusitis, nosebleeds.

From the side of of the cardiovascular system : arterial hypertension, lowering blood pressure, congestive heart failure, migraine, palpitations, vasodilation.

From the hematopoietic system: thrombocytosis, thrombocytopenia, leukocytosis, leukopenia, lymphocytosis, granulocytosis, basophilia, monocytosis, neutropenia, lymphocytopenia, eosinophilia, anemia, hemolytic anemia, decreased hematocrit.

Skin and subcutaneous tissue disorders: dry skin, peeling, itching, skin rash, urticaria, fungal dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Infections and invasions : overgrowth of insensitive microflora and development of infections (fungal, bacterial and parasitic infections) vulvovaginal infections, oral candidiasis.

Other: myalgia, asthenia, fever, chills, weakness, fainting, dehydration, chest pain, back pain, other local pains, hematomas, hair loss.

Laboratory indicators: increased activity of hepatic transaminases, hyperbilirubinemia, increased concentration of LDH, GGT, urea, serum creatinine, hyper- or hypoglycemia, hypoproteinemia and hypoalbuminemia, decreased Hb, positive Coombs reaction, increased prothrombin time.

If the listed reactions occur, as well as a reaction not specified in the instructions, you must consult a doctor.

Is alcohol compatible with antibiotics – Rossiyskaya Gazeta

View from London

The British BBC Future recently published material that, in fact, debunks the long-standing belief that antibiotic treatment is completely incompatible with alcohol.

“Alcohol does not block the action of most drugs and usually does not cause side effects when combined with drugs,” citing recent studies, the report said.- So is it necessary to abstain from alcohol in combination with a course of antibiotics? Many people are convinced that alcohol can prevent drugs from working, and that the combination increases the risk of side effects. In one of the urogenital clinics in London, 300 patients were interviewed – it turned out that the majority (81%) agree with the first statement and almost the same (71%) – with the second.

But in the case of most antibiotics, neither the first nor the second is true, says the English edition.Moreover, from the point of view of doctors, it is much more dangerous when a patient who believes in one of these myths decides not to take the medicine after drinking a glass of wine. Any factor that makes you miss a dose of the drug worsens the effectiveness of treatment, and if you look globally, the serious problem of the emergence of bacterial strains that are resistant to all known antibiotics is aggravated.

However, there are exceptions, the edition stipulates: for example, the drug of the cephalosporin group, cefotetan, slows down the process of alcohol breakdown, as a result of which the level of its decay products increases in the body.And this can lead to undesirable consequences in the form of dizziness, vomiting, flushing of the face, headaches, shortness of breath and chest pains.

Disulfiram has a similar side effect. It is not an antibiotic. The drug is used in the treatment of alcohol addiction. Its action is based on the fact that the patient undergoing treatment begins to feel bad after drinking alcohol – and this should force him to refuse further drinking.

But there is also an antibiotic that has similar properties and therefore is poorly compatible with alcohol – this is metronidazole.It is used in the treatment of infections caused by many types of protozoa and bacteria, including lesions of the nervous system and even some sexually transmitted diseases. When combined with alcohol, it produces the same side effects as the cephalosporins already mentioned.

However, this point of view was questioned after a 2003 review of pharmacological studies. In addition, an experiment was conducted on a small control group of Finnish men, during which they consumed alcohol with metronidazole for 5 days without any unpleasant consequences, writes BBC.

Nevertheless, the authors of the study admit that the likelihood of undesirable effects cannot be completely ruled out, and now doctors still do not recommend combining alcohol with metronidazole.

There are also a few other antibiotics that are best used to avoid drinking, such as tinidazole, linezolid, and erythromycin. But the incompatibility of these drugs with alcohol is well known, and doctors specifically warn patients about it when prescribing a medicine.”Thus, there remains an extensive list of other antibiotics, while taking which it is not dangerous to drink. Of course, alcohol is unlikely to help the treatment of the disease: it can make your body dehydrated and lethargic, but it has nothing to do with drugs,” concludes the publication.

“Perhaps the myth about the incompatibility of antibiotics and alcohol appeared after some unpleasant incidents, but there are two more interesting theories. One is that antibiotics are used in the treatment of common sexually transmitted diseases, and doctors allegedly punished patients for promiscuous behavior, forbidding them to drink a glass or two.

There is another explanation given by James Bingham, one of the authors of the above-mentioned survey of patients at the London Urogenital Clinic. He met with retired Brigadier General Ian Fraser, who during World War II began using penicillin to treat wounded soldiers in North Africa. At that time, there was so little penicillin that after taking the drug by mouth, urine was taken from patients and the drug was again isolated from it. The military who were on treatment were allowed to drink beer, but this led to an increase in the volume of urine produced by the body and, as a result, made it difficult to obtain the medicine.According to General Fraser, therefore, the command decided to ban beer.

Agree, a good story, regardless of whether it influenced the spread of the myth about the incompatibility of alcohol and antibiotics. But debunking myths is a double-edged sword. When a patient, who cannot live without a glass of wine, nevertheless diligently takes a course of antibiotics, it is good, because it helps to fight drug resistance of bacteria.

But if the general public finds out the whole truth, then women who do not want to talk about their pregnancy will have to more ingeniously give up alcohol at parties. “

View from Moscow

How to treat such publications? Is it worth the risk of combining medications with alcohol, or is it better to take care of it? Here is the opinion of the cardiologist Irina Letinskaya.

– I am very wary of such reports, especially when they do not contain clear indications of scientific sources. It should be understood that the compatibility of certain drugs with ethyl alcohol is not specifically tested during clinical trials. Therefore, contraindications are based on the detection of side effects already based on medical practice.

Of course, there are drugs that contain alcohol: tinctures of medicinal plants – hawthorn, peony, valerian, motherwort. But they are used as sedatives, and ethyl alcohol itself in small doses soothes and relaxes.

With regard to antibiotics, I would be very careful here. These are generally very “capricious” drugs. They do not work well with each other and with other medications. They are generally best taken separately from all others.For example, the antibiotic erythromycin is not combined with antihypertensive drugs, antidepressants, antiarrhythmic drugs, and other antibacterial drugs. When mixed with alcohol, the result is even more unpredictable. For example, the antibiotics levomycytin, doxycycline, metronidazole, when taken simultaneously with alcohol (and even the next day after excessive drinking), often cause severe allergic reactions, and the effectiveness of their antibacterial action is reduced. Both the active ingredient of the antibiotic and ethanol are excreted from the body using enzymes produced mainly in the liver.It is no coincidence that most of these drugs are used with caution in patients with impaired liver and kidney function. So why take the risk of loading the liver even more with alcohol?

By the way, there are serious consequences when you combine other drugs with alcohol. So, the old, proven analgin slows down the breakdown of alcohol, increases intoxication. A mixture of alcohol with clonidine leads to the fact that a person “turns off”, plunging into a deep, heavy sleep, his memory is impaired, which was used by criminals more than once.

The combination of alcohol with sleeping pills and tranquilizers is dangerous. Alcohol enhances their effect, which can result in overdose and severe poisoning, up to and including death.

Pecef instruction, price in pharmacies in Ukraine

Composition and form of release

Ingredients

active substance: cefpodoxime;

1 film-coated tablet contains cefpodoxime proxetil equivalent to cefpodoxime 100 mg or 200 mg

Excipients: calcium carboxymethyl cellulose, corn starch, crospovidone (type B), lactose, sodium lauryl sulfate, hydroxypropyl cellulose, magnesium stearate, Opadry White 03H58900 (hypromellose, titanium dioxide (E 171), propylene glycol).

Form of issue

Film-coated tablets (10 tablets in a blister. 1 blister in a cardboard box).

Pharmacological action

Pharmacodynamics

Cefpodoxime proxetil is a beta-lactam antibiotic, belongs to the third generation oral cephalosporins and is an inactive form of cefpodoxime. After oral administration, it is absorbed in the intestine, where it is rapidly hydrolyzed by nonspecific esterases to cefpodoxime, which is then systemically absorbed.

The mechanism of action of cefpodoxime is based on inhibition of the synthesis of bacterial cell walls. Cefpodoxime is resistant to most beta-lactamases.

Cefpodoxime has been shown to have in vitro bactericidal activity against numerous gram-positive and gram-negative bacteria.

Pharmacokinetics

Absorption.

Absorption of cefpodoxime proxetil, taken orally on an empty stomach in tablet form, corresponds to 100 mg of cefpodoxime, 40-50%.It increases with food intake, so it is recommended to use the drug with meals.

Cefpodoxime proxetil is absorbed in the intestine and hydrolyzed to the active metabolite cefpodoxime.

Distribution.

Plasma concentration.

After taking a single dose of 100 mg, the maximum concentration of cefpodoxime in the blood plasma (C _max ) is 1 – 1.2 mg / l. After a single dose of 200 mg, the maximum plasma concentration is 2.2 – 2.5 mg / l.In both cases (100 or 200 mg) C _max is achieved (T _max ) in 2 – 3:00.

Residual concentrations 12:00 after administration of 100 mg and 200 mg are 0.08 mg / l and 0.18 mg / l, respectively.

After taking a dose of 100-200 mg twice a day for 14.5 days, the pharmacokinetic parameters of cefpodoxime in blood plasma do not change, which means there is no accumulation of the active substance.

The volume of distribution of cefpodoxime is 30 – 35 L in young healthy volunteers (0.43 L / kg).

Binding to blood plasma proteins

The level of binding of cefpodoxime is 40%, mainly with albumin. Such binding has no saturation character.

Metabolism and excretion.

After absorption, the main metabolite is cefpodoxime, which is released as a result of the hydrolysis of cefpodoxime proxetil.

Cefpodoxime is metabolized very little.

After absorption of cefpodoxime proxetil, 80% of the released cefpodoxime is excreted unchanged in the urine.

The half-life of cefpodoxime averages 2.4 hours.

Indications for use

Treatment in adults of infections caused by drug-sensitive pathogens, such as:

• tonsillitis;
• acute sinusitis;
• acute bronchitis;
• exacerbation of chronic bronchitis;
• bacterial pneumonia.

Contraindications

Hypersensitivity to cefpodoxime or other drugs of the cephalosporin group, or to any of the excipients.

Immediate and / or severe hypersensitivity reactions (anaphylaxis) to penicillin or other beta-lactam antibiotics in history.

Rare hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndrome.

Method of administration and dosage

For adults, the drug is administered orally 2 times a day with an interval of 12:00 during meals.

Acute bacterial sinusitis: 2 tablets of 200 mg per day, 1 tablet (200 mg) in the morning and in the evening.In acute maxillary sinusitis, the drug is effective for 5 days.

Tonsillitis: 100 mg 2 times a day.

Acute bronchitis : 200 mg 2 times a day.

Exacerbation of chronic bronchitis : 200 mg 2 times a day.

Bacterial pneumonia : 200 mg 2 times a day.

Elderly patients.

No dose adjustment is required for elderly patients with normal renal function.

Renal dysfunction.

No dose adjustment of cefpodoxime is necessary if creatinine clearance exceeds 40 ml / min. If creatinine clearance is below 40 ml / min, the daily dose is halved and taken 1 time per day.

Overdose

In case of an overdose of cefpodoxime, supportive and symptomatic therapy is indicated.

In case of overdose, in particular in patients with renal insufficiency, retrograde encephalopathy may develop.The specific antidote is unknown.

Side effects

Disorders of the digestive system were mainly observed: diarrhea, nausea, vomiting, abdominal pain. General disorders: asthenia, fatigue, malaise.

Several rare cases of adverse reactions have also been reported:

• From the digestive system: as with the use of other broad-spectrum antibiotics, rare cases of enterocolitis with hemorrhagic diarrhea have been reported, as well as rare cases of pseudomembranous colitis, flatulence, acute pancreatitis.
• From the digestive system: a moderate temporary increase in transaminases, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, bilirubin, acute hepatitis.
• Skin: allergic reactions: skin rash, itching, urticaria, Quincke’s edema, anaphylactic shock, various rashes, localized blistering rash, polymorphic erythema, Stevens-Johnson syndrome, Lyell’s syndrome, erythema.
• From the nervous system: headache, dizziness, paresthesia.
• From the kidneys and urinary system: a slight increase in urea and creatininemia, acute renal failure.
• From the circulatory system: thrombocytosis, thrombocytopenia, leukopenia and hypereosinophilia, agranulocytosis, hemolytic anemia, eosinophilia, lymphocytosis, neutropenia, leukocytosis.
• On the part of the organ of hearing and balance: ringing in the ears.

Special instructions

Application during pregnancy and lactation

There are no clinical data on the effect of cefpodoxime proxetil on pregnancy.Considering the expected benefits, the use of cefpodoxime during pregnancy may be considered despite the lack of clinical and animal data. Care should be taken to prescribe the drug to pregnant women if necessary.

The results of animal studies indicate that there is no direct or indirect negative effect of the drug on pregnancy, embryonic / fetal development, childbirth or postpartum development.

Cefpodoxime passes into breast milk, therefore it is recommended to stop breastfeeding for the period of treatment.

Children

To date, there is no information on the use of the drug in children.

The ability to influence the reaction rate when driving vehicles or other mechanisms

During treatment with cefpodoxime, cases of dizziness have been reported, which may affect the ability to drive or operate machinery.

Interaction with other medicinal products and other forms of interaction

Studies have shown that bioavailability is reduced by about 30% when cefpodoxime is used with drugs that neutralize gastric pH or inhibit acid secretion.Thus, drugs such as mineral-type antacids and H ₂ blockers, such as ranitidine, which can lead to an increase in gastric pH, should be taken 2 to 3 hours after using cefpodoxime.

H ₂ histamine antagonists and antacids reduce the bioavailability of cefpodoxime.

An increase in the pH of the stomach: anti-H ₂ (ranitidine) and anti-acids (aluminum hydroxide, sodium bicarbonate) lead to a decrease in biological effectiveness.

Lowering the pH of the stomach (pentagastrin) increases biological effectiveness. The clinical implications remain unclear.

Simultaneous use with probenecid reduces the excretion of cephalosporins. Cephalosporins potentially increase the anticoagulant effect of coumarins and decrease the contraceptive effect of estrogens.

It is recommended to regularly monitor the indicators of the international normalized ratio (INR) during and shortly after the simultaneous use of cefpodoxime with an oral anticoagulant.False positive results of a glucose reaction in urine are possible when using Benedict’s or Fehling’s solution or copper sulfate test tablets, but not when carrying out enzymatic reactions in the presence of glucose oxidase.

Numerous cases of increased action of oral anticoagulants have been reported in patients receiving antibiotics. A clearly pronounced infectious or inflammatory process, the age and general condition of the patient turn out to be risk factors for such an action.

Regardless of the nature of the food, the biological effectiveness of cefpodoxime is increased if the drug is taken with food.

Storage conditions

Store at temperatures below 25 ° C, out of reach of children.

Shelf life – 3 years.

Pay attention!

Description of the drug Pecef on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.Before purchasing or using the drug, you should consult your doctor and familiarize yourself with the original manufacturer’s instructions (attached to each package of the drug).

Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the doses and methods of its use.

Cefpodoxime / Cefpodoxime in Russian – Item

What is cefpodoxime?

Cefpodoxime is an antibiotic used to treat various bacterial infections. It belongs to a group of related antibiotics called cephalosporins, which have something to do with penicillin. The drug is available in various forms and dosages.Like all antibiotics, cefpodoxime has side effects, interacts with other drugs, and may not always be the best choice given the patient’s underlying medical conditions.

Some medical conditions for which cefpodoxime is indicated include bronchitis, cystitis, and sinus infections. It can also be used to treat pneumonia, tonsil infections, and gonorrhea. Other uses for this broad-spectrum antibiotic include skin or soft tissue infections and middle ear infections.

When considering the appropriateness of using cefpodoxime, clinicians must recognize that the drug is a cephalosporin. People are often allergic to more than one cephalosporin, and the likelihood of an allergic reaction to any drug in this group is increased if patients are already allergic to penicillin. Cephalosporins can be very effective medications, but they should be used with caution in people who are allergic to penicillin.

The most common method of delivering this medication is by mouth in tablet form.It may also be available in elixirs to facilitate swallowing and in serums for intravenous delivery. Typically, doses range from 100 to 400 mg (mg) twice daily, although the exact dose may depend on the age and condition being treated. Regardless of the indication, all patients should complete their prescribed medication completely, unless otherwise advised by a physician.

Cefpodoxime has side effects. Serious ones that require immediate medical attention include an allergic reaction, jaundice, sudden onset of flu symptoms, or decreased urination.Other serious side effects include seizures and bloody diarrhea.

Minor side effects of cefpodoxime should be reported if they interfere. These include stomach problems such as vomiting or diarrhea, vaginal yeast infections, thrush, or a sudden increase in anxiety. On the other hand, many patients taking this medication do not experience any side effects.

There are some reported drug interactions with cefpodoxime.People taking medications such as lithium, antacids, or medications that contain aspirin or ibuprofen may need a different antibiotic. For safety reasons, patients should provide doctors with a list of all prescribed and over-the-counter medications they regularly take to prevent any drug interactions.

The biggest contraindication to cefpodoxime is allergy to other cephalosporins. Patients with a history of kidney disease may also need another antibiotic.Some people with past or present bowel disorders, such as irritable bowel syndrome or ulcerative colitis, may also need other medications.

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