Side effects of allopurinol 300mg: Allopurinol Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Allopurinol Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Uses
Allopurinol is used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells. Allopurinol works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.
How to use Allopurinol
Take this medication by mouth as directed by your doctor, usually once daily. Take this medication after a meal to reduce stomach upset. If your dose is more than 300 milligrams a day, you will need to take several smaller doses during the day to get this amount (ask your doctor for directions).
It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions.
Your doctor may also instruct you on how to decrease acid in your urine (such as avoiding large amounts of ascorbic acid/vitamin C).
Dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
For the treatment of gout, it may take up to several weeks for this medicine to have an effect. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Allopurinol is not a pain reliever. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (such as colchicine, ibuprofen, indomethacin) as directed by your doctor.
Tell your doctor if your condition lasts or gets worse.
Side Effects
Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: numbness/tingling of arms/legs, easy bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), signs of liver disease (such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), unusual weight loss, eye pain, vision changes.
Allopurinol may rarely cause very serious (possibly fatal) skin reactions. Some people in certain ethnic groups (such as people of African, Asian, or Native Hawaiian/Pacific Islander descent) are at greater risk. Your doctor may order a blood test to measure your risk before you start this medication. If the blood test shows you are at greater risk, your doctor should discuss the risks and benefits of allopurinol and other treatment choices with you. Get medical help right away if you develop any symptoms of a serious skin reaction, including: skin rash/blisters/peeling, itching, or swelling.
Ask your doctor or pharmacist for more details.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; or if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (such as fasting).
This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Alcohol may also decrease the effectiveness of this drug. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Allopurinol passes into breast milk. Consult your doctor before breast-feeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug are: “blood thinners” (such as warfarin), capecitabine, didanosine.
Does Allopurinol interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
Lab and/or medical tests (such as uric acid blood levels, liver/kidney function, complete blood count) may be done while you are taking this medication.
Keep all medical and lab appointments. Consult your doctor for more details.
If you are taking allopurinol to treat kidney stones, you may benefit from a special diet. Consult your doctor for more details.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
allopurinol 300 mg tablet
Color: orangeShape: roundImprint: 2084 V
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: AW
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: light peachShape: roundImprint: 1 2 10
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: 1 209
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: off-whiteShape: roundImprint: 0524 0405
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: orangeShape: roundImprint: DAN DAN 5544
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: orangeShape: roundImprint: MP 80
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: orangeShape: roundImprint: 5544 DAN DAN
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: 5543 DAN DAN
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: orangeShape: roundImprint: N021
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: M 31
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: MP 71
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: off-whiteShape: roundImprint: AL3
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: whiteShape: roundImprint: AX
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: 349 U
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: whiteShape: roundImprint: M 71
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: 2083 V
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 300 mg tablet
Color: whiteShape: roundImprint: 350 U
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: N020
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
allopurinol 100 mg tablet
Color: whiteShape: roundImprint: RG 10
This medicine is a orange, round, scored, tablet imprinted with “2084 V”.
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Selected from data included with permission and copyrighted by First Databank, Inc.
This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Side effects of allopurinol – NHS
Like all medicines, allopurinol can cause side effects, but many people have no side effects or only minor ones.
Common side effects
There are things you can do to cope with these common side effects of allopurinol:
Feeling or being sick (nausea or vomiting)
If you’re feeling sick, eat little and often and drink lots of fluids such as water or squash.
Also try taking your medicine with, or just after, a meal or snack. Stick to simple meals and do not eat rich or spicy food.
If you’re being sick, take small, frequent sips of water to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.
If you take contraceptive pills and you’re being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.
Serious side effects
It’s unusual to have serious side effects after taking allopurinol. Tell a doctor or call 111 now if:
- the whites of your eyes or your skin turn yellow, although this is less obvious on black or brown skin – these can be signs of a liver problem
- you get a high temperature, sore throat and swollen glands or feel generally unwell – this could mean there are problems with your white blood cells
- you have bruising for no obvious reason or bleeding gums (which takes a long time to stop) when brushing your teeth
- you are unusually thirsty, going to the toilet to pee a lot, unusually tired, losing weight without trying, or have blurred vision – these could be signs of diabetes
Skin rashes
Stevens-Johnson syndrome is a rare side effect of allopurinol.
It causes flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off.
It’s more likely to happen in the first 8 weeks of taking allopurinol, or when the dose is increased too quickly. It can also happen if allopurinol is stopped suddenly for a few days and then restarted at the same dose as before. It’s better to reduce the dose and then increase it slowly.
Stevens-Johnson syndrome is more common in:
- children
- people who developed a rash with an epilepsy medicine in the past
- people who are allergic to an antibiotic called trimethoprim
- people also taking a medicine called sodium valproate
To help prevent the chance of you getting a rash that could be confused with Stevens-Johnson syndrome, it’s best not to try new medicines or food during the first 3 months of treatment with allopurinol.
It’s also best to not start taking allopurinol within 2 weeks of a viral infection, vaccination, or rash caused by something else.
Immediate action required: Go to A&E now if:
- you get a skin rash with flushing, blisters or ulcers – these can be signs of Stevens-Johnson syndrome
Find your nearest A&E
Serious allergic reaction
In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to allopurinol.
Immediate action required: Call 999 now if:
- your lips, mouth, throat or tongue suddenly become swollen
- you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- your throat feels tight or you’re struggling to swallow
- your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- you suddenly become very confused, drowsy or dizzy
- someone faints and cannot be woken up
- a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)
You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.
These can be signs of a serious allergic reaction and may need immediate treatment in hospital.
Other side effects
These are not all the side effects of allopurinol. For a full list, see the leaflet inside your medicines packet.
Information:
You can report any suspected side effect using the Yellow Card safety scheme.
Visit Yellow Card for further information.
Page last reviewed: 23 January 2023
Next review due: 23 January 2026
Arpimed
What Allopurinol is and what it is used for
Allopurinol is the active ingredient in Allopurinol. Allopurinol slows down the rate of certain chemical reactions in the human body, resulting in lower levels of uric acid in the blood and urine.
Allopurinol is prescribed to reduce or prevent the deposition of uric acid and its salts (urates) in conditions where the body produces too much uric acid.
These include gout, certain types of urolithiasis and kidney dysfunction, cancer treatment, and some other conditions. With gout, uric acid accumulates in the joints and in the muscle ligaments in the form of salt crystals. These crystals lead to the development of inflammatory reactions. Inflammatory reactions contribute to the development of edema of the periarticular tissue, excessive sensitivity and pain with a light touch. When moving in the joints, severe pain may begin.
What you need to know before you use Allopurinol
Do not take Allopurinol. If you have any doubts, you should consult your doctor or pharmacist before using allopurinol. Warnings and precautions Talk to your doctor or pharmacist before using allopurinol, Special care must be taken when using allopurinol: If you develop a rash or other skin reaction, stop taking allopurinol and call your healthcare provider right away. Children In children, the use of allopurinol is limited, except for certain types of cancer (particularly leukemia) and certain enzymatic disorders such as Lö’s syndrome sha – Nihena. Drug interactions Tell your doctor or pharmacist if you are taking the following medicines: Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including OTC and herbal medicines. Allopurinol may interfere with the effects of certain drugs. Some drugs can also interfere with the effects of allopurinol. Pregnancy and lactation Talk to your doctor before using allopurinol if you are pregnant, think you might be pregnant, or are breastfeeding. Influence on the ability to drive vehicles and mechanisms If you feel drowsiness, dizziness or incoordination, do not drive vehicles or other mechanisms. How to take Allopurinol Allopurinol should be taken exactly as directed by your doctor. If you have any doubts, you should consult your doctor or pharmacist. Allopurinol should be taken after meals with 1 glass of water. The recommended daily dose is 100-900 mg. Start treatment with allopurinol, usually at a low dose, gradually increasing to the optimal maintenance dose that meets the needs of the patient. If you are an elderly patient or have liver or kidney failure, your doctor may prescribe a lower dose or increase the interval between taking allopurinol. If you are on dialysis 2-3 times a week, your doctor may prescribe a dose of 300-400 mg to be taken immediately after the dialysis session. Children under 15: The daily maintenance dose is usually 100-400 mg.
If you have taken more Allopurinol than recommended
If you have taken more Allopurinol than recommended, contact your doctor or go to the nearest hospital. Take the medicine package with you. Overdose symptoms are nausea, vomiting, diarrhea and dizziness.
If you forget to take Allopurinol
If you forget to take your next dose, take it as soon as you remember. If it is time for your next allopurinol dose, skip the missed dose.
Do not take a double dose to make up for a missed one.
If you stop taking Allopurinol
You should talk to your doctor before stopping allopurinol.
If you have any further questions about taking this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, allopurinol can cause side effects, although not everybody gets them. These symptoms include:
Hypersensitivity
Uncommon side effects (may affect up to 1 in 100 people)
If you experience an allergic reaction, stop taking allopurinol immediately and contact your doctor or the nearest hospital.
These symptoms include:
- exfoliative dermatitis, furunculosis and stomatitis
- very rare symptoms such as sudden wheezing, anxiety and tightness in the chest and collapse
Rare side effects (may affect up to 1 in 1000 people)
- fever, chills, headache, muscle aches (flu-like symptoms) and general malaise.
- severe allergic reactions, including fever, skin rash, joint pain, abnormal blood and liver tests, which are signs of multiple organ dysfunction.
- Bleeding from lips, eyes, mouth, nose and genitals.
- Any changes in the skin, such as sores in the mouth, throat, nose, genitals, conjunctivitis (red and swollen eyes), blistering and desquamation of the epidermis throughout the body.
Do not take more allopurinol than prescribed by your doctor.
Other possible side effects
Common side effects (may affect up to 1 in 10 people)
- skin rash 9 0018
Uncommon side effects (may affect up to 1 in 100 people)
- nausea and vomiting
- violation of liver tests
Rare side effects (may affect up to 1 in 1000 people)
- liver problems such as inflammation of the liver
Very rare side effects (may affect up to 1 in 10,000 people)
- disorders of the hematopoietic system, which may lead to bruising from minor exposures or sore throat or other symptoms of infection. These symptoms often appear in patients with impaired liver or kidney function. In this case, you should immediately consult a doctor.
- lymph node involvement
- high temperature
- presence of blood in the urine (hematuria)
- elevated blood cholesterol level (hyperlipidemia)
- general feeling unwell or feeling weak
- weakness, numbness, unsteadiness when standing, feeling unable to make voluntary muscle movements (paralysis) or loss of consciousness
- headache, dizziness, drowsiness or blurred vision
- chest pain (angina pectoris), high blood pressure or weak pulse
- male infertility or erectile dysfunction
- breast enlargement in both men and women
- bowel dysfunction
- taste disorders
- cataract
- hair loss or discoloration
- depression
- disorders of voluntary coordination of muscular movements (ataxia)
- tingling, tickling and burning sensation (paresthesia)
- swelling of the lower extremities, especially in the ankles.
- Impaired glucose tolerance. If this occurs, your doctor will need to periodically check your blood glucose levels.
These symptoms often appear in patients with impaired liver or kidney function. In this case, you should immediately consult a doctor.
If you experience any serious side effects or side effects not listed in this package leaflet, contact your doctor or pharmacist.
Reporting side effects
If you notice any side effects, tell your doctor, pharmacist or pharmacist, including any side effects not listed in this package insert. You can also report side effects to Arpimed LLC by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a medicine” and to the Scientific Center for Expertise of Drugs and Medical Technologies named after. Academician E.Gabrielyan, by going to the website www.pharm.am in the section “Report a side effect of a drug” and fill out the form “Map of reporting a side effect of a drug”. Scientific center hotline: +37410237665; +37498773368
How to store Allopurinol
- Keep out of the reach of children, protected from moisture and light at a temperature of 15 0 C-25 0 C.
- Shelf life – 3 years. Do not use allopurinol after the expiry date which is stated on the package. When specifying the expiration date, the last day of the specified month is meant.
- Drugs should not be disposed of into wastewater or sewers. Ask your pharmacist how to dispose of a medicine you no longer need. These measures are aimed at protecting the environment.
Contents of the pack and additional information
What Allopurinol
contains One tablet contains:
active substance : allopurinol-300 mg;
excipients : microcrystalline cellulose, corn starch, sodium starch glycolate, magnesium stearate, sodium lauryl sulfate.
What Allopurinol looks like and contents of the pack
White, round, biconvex tablets scored on one side.
Carton containing 30 tablets (3 blisters of 10 tablets) with leaflet.
Dispensing conditions
Prescription
Allopurinol – description of the substance, pharmacology, use, contraindications, formula
Contents
Structural formula
Russian name
English name
Latin name
chemical name
Gross formula
Pharmacological group of the substance Allopurinol
Nosological classification
CAS code
pharmachologic effect
Characteristic
Pharmacology
The use of the substance Allopurinol
Contraindications
Application restrictions
Use during pregnancy and lactation
Side effects of Allopurinol
Interaction
Overdose
Dosage and administration
Precautionary measures
Trade names with the active substance Allopurinol
Structural formula
Russian name
Allopurinol
English name
Allopurinol
Latin name
Allopurinolum ( born Allopurinoli)
Chemical name
1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
General formula
C 5 H 4 9 0418 N 4 O
Pharmacological group of the substance Allopurinol
Drugs affecting the metabolism of uric acid
Nosological classification
List of ICD-10 codes
CAS code
315-30-0
Pharmacological action
Pharmacological action –
hypouricemic , antigout .
Characteristics
White or creamy white fine crystalline powder, insoluble in water and alcohol.
Pharmacology
Inhibits xanthine oxidase, disrupts the conversion of hypoxanthine to xanthine and xanthine to uric acid; thus limits the synthesis of uric acid. Lowers the content of urates in the blood serum and prevents their deposition in tissues, incl. renal. Reduces the excretion of uric acid in the urine and increases the more readily soluble hypoxanthine and xanthine.
Almost completely (90%) absorbed from the gastrointestinal tract. In the liver, under the influence of xanthine oxidase, it turns into alloxanthin, which also prevents the formation of uric acid. max “> C max allopurinol is achieved after 1.5 hours, alloxanthin – 4.5 hours after a single dose. 1/2″> T 1/2 allopurinol is 1-2 hours, alloxanthin – about 15 hours. About 20% of the dose is excreted through the intestines; the rest of allopurinol and its metabolites – by the kidneys.
Application of the substance Allopurinol
Hyperuricemia: primary and secondary gout, urolithiasis with urate formation; diseases accompanied by increased breakdown of nucleoproteins, incl. hematoblastomas, cytostatic and radiation therapy of tumors, psoriasis, traumatic toxicosis, corticosteroid therapy to prevent uric acid nephropathy; Lesch-Nyhan syndrome, purine metabolism disorders in children, urolithiasis and the formation of calcium oxalate stones in hyperuricosuria (prevention and treatment).
Contraindications
Hypersensitivity, liver failure, chronic renal failure (azotemia stage), primary (idiopathic) hemochromatosis, asymptomatic hyperuricemia, acute gout attack, pregnancy, breastfeeding.
Restrictions for use
Renal failure, chronic heart failure, diabetes mellitus, arterial hypertension, children’s age (up to 14 years of age, it is prescribed only during cytostatic therapy of leukemia and other malignant diseases, as well as symptomatic treatment of enzyme disorders).
Use in pregnancy and lactation
FDA category of action on the fetus – C.
Side effects of the substance Allopurinol
From the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea , stomatitis, hyperbilirubinemia, cholestatic jaundice, increased activity of hepatic transaminases and alkaline phosphatase; rarely – hepatonecrosis, hepatomegaly, granulomatous hepatitis.
From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): pericarditis, increased blood pressure, bradycardia, vasculitis, agranulocytosis, anemia, aplastic anemia, thrombocytopenia, eosinophilia, leukocytosis, leukopenia.
From the side of the musculoskeletal system: myopathy, myalgia, arthralgia.
From the nervous system and sensory organs: headache, peripheral neuropathy, neuritis, paresthesia, paresis, depression, drowsiness, taste perversion, loss of taste, visual impairment, cataract, conjunctivitis, amblyopia.
From the genitourinary system: acute renal failure, interstitial nephritis, increased urea concentration (in patients with initially reduced kidney function), peripheral edema, hematuria, proteinuria, decreased potency, infertility, gynecomastia.
Allergic reactions: skin rash, pruritus, urticaria, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), purpura, bullous dermatitis, eczematous dermatitis, exfoliative dermatitis; rarely – bronchospasm.
Other: furunculosis, alopecia, diabetes mellitus, dehydration, epistaxis, necrotizing tonsillitis, lymphadenopathy, hyperthermia, hyperlipidemia.
Interaction
Increases blood concentration and toxicity of azathioprine, mercaptopurine, methotrexate, xanthines (theophylline, aminophylline), hypoglycemic effect of chlorpropamide, anticoagulant – indirect anticoagulants. Pyrazinamide, salicylates, uricosuric agents, thiazide diuretics, furosemide, ethacrynic acid weaken the hypouricemic effect.
Against the background of amoxicillin, ampicillin, bacampicillin, the likelihood of a skin rash increases.
Overdose
Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.
Treatment: forced diuresis, hemo- and peritoneal dialysis.
Dosage and administration
Inside. The dose of the drug is selected individually, the effectiveness of therapy is monitored in the initial stages by re-determining the level of uric acid in the blood (desired level <0.36 mmol / l). A decrease in the level of uric acid under the influence of the drug occurs after 24-48 hours. Beginning with 100 mg / day, once, then the dose is gradually increased. A daily dose of more than 300 mg should be divided into several doses.
Adults with mild disease — 100–200 mg/day, with moderate disease — 300–600 mg/day, with severe disease — 700–900 mg/day. Children from 10 to 15 years old – 10-20 mg / kg / day (up to 400 mg / day maximum), up to 10 years old – 5-10 mg / kg / day.
In patients with impaired renal excretory function, the daily dose should be reduced. Elderly patients are recommended the lowest doses.
Precautions
Maintain urine output of at least 2 liters per day and neutral or slightly alkaline urine, as this prevents urate precipitation and calculus formation. You should not start therapy until the acute attack of gout is completely relieved; during the first month of treatment, prophylactic NSAIDs or colchicine are recommended; in the event of an acute attack of gout during treatment, anti-inflammatory drugs are additionally prescribed. In case of impaired renal and hepatic function (increased risk of side effects), the dose is reduced. The first 6-8 weeks of treatment requires a regular study of liver function, with blood diseases, regular laboratory monitoring is required.
If a skin rash appears, the drug is canceled, after the disappearance of a mild rash, it is possible to re-administer the drug, if it recurs, the treatment is immediately stopped.