MethylPREDNISolone Dose Pack Interactions – Drugs.com

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There are 561 drugs known to interact with
MethylPREDNISolone Dose Pack (methylprednisolone), along with
23 disease interactions, and 3 alcohol/food interactions.

Of the total drug interactions,
93 are major, 431 are moderate, and 37 are minor.

Does MethylPREDNISolone Dose Pack interact with my other drugs?

Enter other medications to view a detailed report.

• View all 561 medications that may interact with MethylPREDNISolone Dose Pack
• View MethylPREDNISolone Dose Pack alcohol/food interactions (3)
• View MethylPREDNISolone Dose Pack disease interactions (23)

Most frequently checked interactions

View interaction reports for MethylPREDNISolone Dose Pack (methylprednisolone) and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• albuterol
• amlodipine
• aspirin
• atorvastatin
• Benadryl (diphenhydramine)
• cyclobenzaprine
• doxycycline
• fluticasone nasal
• gabapentin
• hydrochlorothiazide
• hydroxyzine
• ibuprofen
• levothyroxine
• lisinopril
• losartan
• melatonin
• meloxicam
• metformin
• naproxen
• omeprazole
• pantoprazole
• prednisone
• tizanidine
• tramadol
• trazodone
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Zyrtec (cetirizine)

MethylPREDNISolone Dose Pack alcohol/food interactions

There are 3 alcohol/food interactions with MethylPREDNISolone Dose Pack (methylprednisolone).

MethylPREDNISolone Dose Pack disease interactions

There are 23 disease interactions with MethylPREDNISolone Dose Pack (methylprednisolone) which include:

• infections
• prematurity
• (+) tuberculin test
• cirrhosis
• depression/psychoses
• diabetes
• electrolyte imbalance
• fluid retention
• GI perforation
• hyperadrenocorticalism
• hyperlipidemia
• hypothyroidism
• liver disease
• MI
• myasthenia gravis
• myopathy
• ocular herpes simplex
• ocular toxicities
• osteoporosis
• PUD
• scleroderma
• strongyloidiasis
• thromboembolism

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More about MethylPREDNISolone Dose Pack (methylprednisolone)

• MethylPREDNISolone Dose Pack consumer information
• Compare alternatives
• Pricing & coupons
• Reviews (44)
• Side effects
• Dosage information
• During pregnancy
• Drug class: glucocorticoids
• Breastfeeding
• En español

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Medrol (Pak) Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system’s response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. This medication is a corticosteroid hormone.Methylprednisolone may also be used with other medications in hormone disorders.

How to use Medrol

Take this medication by mouth as directed by your doctor, usually with food or milk. Follow your dosing instructions carefully. The dosage and length of treatment are based on your medical condition and response to treatment. Different dosing schedules exist for this medication. If you are not taking the same dose each day or if you take this medication every other day, it may help to mark your calendar with a reminder. Consult your doctor or pharmacist if you have any questions.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used methylprednisolone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. See also Precautions section.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Nausea, vomiting, heartburn, headache, dizziness, trouble sleeping, appetite changes, increased sweating, or acne may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough, white patches in the mouth).

Tell your doctor right away if you have any serious side effects, including: unusual weight gain, menstrual period changes, bone/joint pain, easy bruising/bleeding, mental/mood changes (such as mood swings, depression, agitation), muscle weakness/pain, puffy face, slow wound healing, swelling of the ankles/feet/hands, thinning skin, unusual hair/skin growth, vision problems, fast/slow/irregular heartbeat, symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds).

Get medical help right away if you have any very serious side effects, including: seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking methylprednisolone, tell your doctor or pharmacist if you are allergic to it; or to prednisone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood clots, brittle bones (osteoporosis), diabetes, eye diseases (such as cataracts, glaucoma, herpes infection of the eye), heart problems (such as recent heart attack, congestive heart failure), high blood pressure, current/past infections (such as those caused by tuberculosis, threadworm, herpes, fungus), kidney disease, liver disease, mental/mood conditions (such as psychosis, depression, anxiety), stomach/intestinal problems (such as diverticulitis, ulcer, ulcerative colitis), seizures.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information.

Methylprednisolone can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.

Tell your health care professional that you are using methylprednisolone before having any immunizations, vaccinations, or skin tests. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication. See also Medical Alert section.

Older adults may be more sensitive to the side effects of this drug, especially bone loss/pain, stomach/intestinal bleeding, and mental/mood changes (such as confusion).

This medication may slow down a child’s growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child’s height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for a long time may have hormone problems. Tell your doctor right away if you notice symptoms such as nausea/vomiting that doesn’t stop, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aldesleukin, mifepristone, other drugs that can also cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, “blood thinners” such as warfarin/dabigatran, NSAIDs such as ibuprofen, celecoxib, aspirin, salicylates).

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Other medications can affect the removal of methylprednisolone from your body, which may affect how methylprednisolone works. Examples include azole antifungals (such as ketoconazole), cyclosporine, estrogens, HIV protease inhibitors (such as darunavir), macrolide antibiotics (such as erythromycin), ritonavir, St. John’s wort, some drugs used to treat seizures (such as phenytoin, phenobarbital), among others.

This medication may interfere with certain laboratory tests (such as skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Medrol interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

If this medication is used for a long time, lab and/or medical tests (such as blood sugar/mineral levels, blood pressure, eye exams, bone density tests, height/weight measurements) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Taking this medication for a long time may cause brittle bones (osteoporosis). Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, getting enough calcium and vitamin D, and limiting alcohol. Consult your doctor for specific advice.

If you are taking this medication once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

If you do not take the same dose each day or if you take this medication every other day, ask your doctor or pharmacist what you should do if you miss a dose.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Medrol (Pak) 4 mg tablets in a dose pack

Color: whiteShape: ellipticalImprint: MEDROL 4

This medicine is a white, elliptical, double-scored, tablet imprinted with “MEDROL 4”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The use of methylprednisolone in the treatment of children with cancer

Chemotherapy
Supportive care

Trademarks:

Depo-Medrol®, Medrol®, Solu-Medrol®

Other names:

Methylprednisolone Acetate, Methylprednisolone Sodium Succinate

Often used for:

Leukemia, lymphoma, side effects of cancer treatment, graft versus host disease (GVHD) after stem cell transplant

Methylprednisolone is a corticosteroid that is also used in chemotherapy. In addition, it can be used as an anti-inflammatory agent or an immunosuppressant.

Methylprednisolone can be used to reduce the body’s natural immunity to prevent and treat GVHD during hematopoietic cell transplantation. In addition, it can be used to treat inflammation, allergies, asthma, skin rashes, pneumonia, and adrenal disorders.

During treatment, urine and blood tests may be done to monitor blood sugar, potassium, calcium, and certain hormones. With long-term use of methylprednisolone, the patient will be monitored to identify possible disturbances in the functioning of the organs of vision and changes in growth.

Oral tablets

Administered intravenously (by drip) in liquid form

Intramuscular injection in liquid form

• Sleep disorders
• Increased appetite
• Character changes or mood swings
• Anxiety
• Stomach irritation
• Heartburn
• Nausea or vomiting
• Fluid retention, swelling of the legs or feet
• Increased risk of infection
• Slow wound healing
• High blood sugar

• Increased fatigue or general weakness
• Headache
• Dizziness
• Acne
• Dry skin
• Increased sweating
• Visual disturbances
• Changes in the menstrual cycle

The listed side effects are not observed in all patients who are prescribed methylprednisolone. The most common side effects are highlighted in bold, but others are not excluded. Report all possible side effects to your doctor or pharmacist.

Some patients may experience long-term side effects or long-term effects that persist from the time of taking the drug or appear only several months or years after the end of the drug. Possible side effects with long-term use of methylprednisolone: ​​

• Muscle loss and muscle weakness
• Growth disorders
• Thin, fragile skin
• Brittle bones, osteoporosis
• Eye disorders including cataracts and glaucoma
• Secondary cancer (Kaposi’s sarcoma)

Be sure to discuss these and other recommendations with your doctor or pharmacist.

• Your healthcare team may recommend a diet that is low in sodium and sugar and high in protein. A nutritionist will give advice on healthy eating with increased appetite.
• Sexually active patients should use contraceptive methods during the course of therapy.
• Pregnant or breastfeeding patients should notify their physician.

Home use of methylprednisolone: ​​

• Methylprednisolone should be taken at the same time each day. When used once a day, the drug must be taken in the morning.
• The drug should be taken with food or milk to reduce stomach irritation.
• Methylprednisolone should be stored at room temperature.
• Take your dose as soon as possible if you miss it. Do not do this only if there is little time left until the next appointment. In no case do not double the dose at the next dose!
• Do not use an expired drug.
• Follow instructions for safe handling and disposal.

Additional information about methylprednisolone

• Safe storage and disposal of medicines
• Sex life in therapy
• Prednisone

More about methylprednisolone

Analogs, side effects, what helps

Glucocorticosteroids are hormones that are produced in our body by the adrenal cortex. In medicine, synthetic analogues are used, which are prescribed for a lack of their own hormones, to suppress inflammation, and for allergic and immune reactions.

Glucocorticosteroids (GCS) are very “strong” drugs. Synthetic analogs of natural hormones are more anti-inflammatory than hormones in the body. This property is used to treat inflammatory diseases of the musculoskeletal system, gastrointestinal tract, connective tissue, skin, and respiratory organs. GCS is prescribed for eye diseases, allergic reactions, oncological and hematological diseases, edema and organ transplantation.

Alena Podoinitsyna, a pharmacist, talks about one of these steroid hormones, Metipred: its composition, dosage, regimen of administration and withdrawal, side effects and analogues.

All products Metipred 25 reviews

Metipred: composition

Metipred contains methylprednisolone, a synthetic hormone-glucocorticoid. It has immunosuppressive, anti-allergic, anti-inflammatory, anti-shock and anti-toxic effects.

The drug is produced in the form of a lyophilisate for the preparation of an injection solution and tablets.

Metipred: dosage

For therapeutic schemes, the following dosages of the drug are used:

• Metipred tablets 4 mg and 16 mg
• Metipred lyophilisate for solution for intravenous and intramuscular administration

The dosage and regimen of the drug depends on the disease and is prescribed by the attending physician. So, with rheumatoid arthritis, two options are possible:

• 1 g per day intravenously for three or four days
• 1 g per month for six months.

In emergencies, Metipred is administered intravenously. High doses of Metipred can cause cardiac arrhythmias, so this treatment is carried out only in a hospital with an ECG and a defibrillator. The injection solution is prepared using the solvent in the kit. The prepared solution can be mixed with 5% dextrose solution or 0. 9% sodium chloride solution.

The dosage of tablets may vary according to the nature of the disease and range from 4 to 48 mg per day. High doses are prescribed for multiple sclerosis (200 mg per day), cerebral edema (200-1000 mg per day) and organ transplantation (7 mg / kg per day).

For long-term use of Metipred, alternative therapy is often prescribed. It represents a special dosing regimen: twice the daily dose is taken in the morning every other day. At the same time, the maximum therapeutic effect is achieved and side reactions are reduced, such as GCS withdrawal syndrome, suppression of the own pituitary-adrenal system, Itsenko-Cushing’s syndrome and growth retardation in children.

Children in the period of growth are prescribed Metipred only according to absolute indications and under strict medical supervision. The initial dose is 0.5 mg/kg body weight per day. When choosing a dose, the doctor focuses on the severity of the condition and the patient’s response to treatment, and not on age or body weight.

Metipred: before or after meals

Metipred tablets do not indicate when to take them in relation to food. Due to the fact that the drug can cause erosive processes in the stomach and intestines, doctors recommend doing this during meals or immediately after it, drinking a small amount of water.

Metipred withdrawal regimen

After long-term treatment with Metipred, drug withdrawal should be gradual. This is due to the occurrence of a “withdrawal syndrome” and secondary secondary insufficiency of the adrenal cortex.

When the therapy has a positive effect, the patient is adjusted to an individual maintenance dose. To do this, the initial dose at certain intervals is gradually reduced to the minimum dose that can maintain the achieved clinical effect. At the same time, the dosing regimen of Metipred is strictly controlled for timely dose adjustment according to the circumstances. Long-term therapy should not be stopped abruptly.

Metipred side effects

Therapy with Metipred carries risks of side effects that increase with long-term use and doses greater than 6 mg per day.

During the course of treatment, the following are possible:

Taking Metipred has special side effects for women – increased body hair and irregular menstruation.

Metypred crosses the placental barrier. The drug is prescribed during pregnancy only according to absolute indications in the case when the benefit to the woman is higher than the risk of a negative effect on the fetus.

There is only one contraindication for short-term use of a medicine for health reasons: hypersensitivity to methylprednisolone.

Contraindications for use

• systemic mycosis;
• simultaneous use of live and attenuated vaccines with immunosuppressive doses of the drug;
• breastfeeding period.

Metypred analogues

Methylprednisolone is a constituent of the following medicines:

• Solu-Medrol
• Medrol
• Methylprednisolone
• Ivepred

Subject to the form of release and dosage, the preparations are interchangeable.

All products Medrol 20 reviews

All products Solu-Medrol 5 reviews

Metipred or Prednisolone: ​​which is better

Prednisolone – the active ingredient in the dosage forms of Prednisolone – has the same effect on the body as Metipred. There are dosage forms of Prednisolone on the market in the form of tablets, an injection solution, a lyophilisate for the preparation of an injection solution and an ointment for external use.

Indications for both drugs are similar, contraindications for prednisolone are less – only hypersensitivity to the components. Prednisolone regimens are set individually. With prolonged therapy, the drug is also canceled gradually. The longer the course treatment was, the slower the maintenance dose is reduced.

The difference between Metipred and Prednisolone is the effectiveness of the action: Metipred at a dosage of 4 mg is equivalent in effect to 5 mg of Prednisolone. And also in a larger number of dosage forms and manufacturers of the drug under the trade name Prednisolone.

Both drugs are proven to work. Metipred or Prednisolone – the question of prescribing analogues to a particular patient is decided by the attending physician.

Summary

• The active ingredient of Metipred is a synthetic glucocorticosteroid hormone Methylprednisolone.