What is nabumetone used for. How does nabumetone work to treat arthritis. What are the potential side effects and risks of taking nabumetone. Who should not take nabumetone. How to take nabumetone safely and effectively.

What is Nabumetone and How Does it Work?

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat certain types of arthritis. It works by reducing inflammation and pain in the joints. Nabumetone is available under the brand names Relafen and Relafen DS.

How exactly does nabumetone work in the body? Nabumetone inhibits the production of prostaglandins, which are chemicals in the body that cause inflammation, pain, and fever. By blocking prostaglandin synthesis, nabumetone helps reduce arthritis symptoms like joint pain, stiffness, and swelling.

Indications and Uses for Nabumetone

The primary use of nabumetone is for treating arthritis, including:

• Rheumatoid arthritis
• Osteoarthritis
• Juvenile rheumatoid arthritis

Is nabumetone only used for arthritis? While arthritis is the main indication, doctors may sometimes prescribe nabumetone off-label for other conditions involving pain and inflammation. However, it’s important to only use nabumetone as directed by your healthcare provider for approved uses.

Important Safety Warnings for Nabumetone

There are some critical safety warnings to be aware of with nabumetone:

Cardiovascular Risks

Nabumetone may increase the risk of serious cardiovascular events like heart attack and stroke. This risk may be higher with longer use or higher doses. The risk exists even for people without pre-existing heart disease or risk factors.

Gastrointestinal Risks

Nabumetone can increase the chance of severe gastrointestinal problems like ulcers and bleeding in the stomach or intestines. These issues may occur without warning signs and can be life-threatening, especially in older adults.

Can these risks be mitigated? While the risks cannot be completely eliminated, using the lowest effective dose for the shortest duration necessary can help reduce potential adverse effects. Close monitoring by your doctor is also important.

Who Should Not Take Nabumetone?

Certain people should avoid taking nabumetone due to increased risks. You should not use this medication if you:

• Are allergic to nabumetone or other NSAIDs
• Have a history of asthma, hives, or allergic reactions to aspirin
• Have active stomach or intestinal bleeding
• Have severe kidney problems
• Have recently had or are about to have heart bypass surgery
• Are in the last trimester of pregnancy

Are there any other conditions that require caution with nabumetone? Yes, people with a history of ulcers, bleeding disorders, heart disease, high blood pressure, liver disease, or asthma should use nabumetone cautiously and only under close medical supervision.

Potential Side Effects of Nabumetone

Like all medications, nabumetone can cause side effects. Common side effects may include:

• Stomach pain or discomfort
• Nausea
• Heartburn
• Diarrhea
• Constipation
• Headache
• Dizziness
• Drowsiness

What are some of the more serious side effects to watch out for? Serious side effects that require immediate medical attention include:

• Signs of heart problems (chest pain, shortness of breath, weakness, slurred speech)
• Signs of stomach bleeding (bloody or tarry stools, coughing up blood)
• Signs of liver problems (nausea, upper stomach pain, fatigue, dark urine, jaundice)
• Signs of kidney problems (little or no urination, swelling in feet or ankles)
• Severe skin reactions (fever, sore throat, burning eyes, skin pain, red or purple skin rash)

Drug Interactions with Nabumetone

Nabumetone can interact with various medications, potentially increasing risks or altering effectiveness. Some important drug interactions to be aware of include:

• Other NSAIDs or aspirin
• Blood thinners like warfarin
• Certain antidepressants (SSRIs)
• Diuretics
• ACE inhibitors or ARBs for blood pressure
• Methotrexate
• Lithium

How can you prevent drug interactions? Always inform your healthcare provider about all medications, supplements, and herbal products you’re taking. Your doctor may need to adjust dosages or monitor you more closely if you’re taking any interacting drugs.

Proper Usage and Dosing of Nabumetone

To use nabumetone safely and effectively:

1. Take nabumetone exactly as prescribed by your doctor
2. Use the lowest effective dose for the shortest duration possible
3. Take nabumetone with food to reduce stomach upset
4. Do not crush, chew, or break extended-release tablets
5. Avoid alcohol while taking nabumetone
6. Do not take more than the recommended dose

What is the typical dosage for nabumetone? The usual starting dose for adults is 1000 mg taken once daily. Some patients may require 1500-2000 mg daily, often divided into two doses. However, dosage can vary based on individual factors and should be determined by your doctor.

Monitoring and Follow-up While Taking Nabumetone

Regular monitoring is crucial when taking nabumetone long-term. Your healthcare provider may recommend:

• Periodic blood tests to check liver and kidney function
• Blood pressure checks
• Monitoring for signs of gastrointestinal bleeding
• Assessing cardiovascular risk factors

How often should you follow up with your doctor while taking nabumetone? The frequency of follow-ups will depend on your individual health status and risk factors. Generally, patients on long-term NSAID therapy should have check-ups at least every 3-6 months.

Alternative Treatments for Arthritis

While nabumetone can be effective for managing arthritis symptoms, it’s not the only option. Other treatments that may be considered include:

• Other NSAIDs (ibuprofen, naproxen, celecoxib)
• Acetaminophen for pain relief
• Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis
• Corticosteroid injections
• Physical therapy and exercise
• Weight management
• Complementary therapies (acupuncture, massage)

Are there any natural alternatives to nabumetone for arthritis? Some people find relief with natural remedies like omega-3 fatty acids, turmeric, or glucosamine and chondroitin supplements. However, it’s important to discuss any alternative treatments with your healthcare provider before trying them.

Special Considerations for Nabumetone Use

Pregnancy and Breastfeeding

Nabumetone should be avoided during the last trimester of pregnancy due to risks to the fetus. It may be used cautiously during early pregnancy if the benefits outweigh the risks. Nabumetone can pass into breast milk, so breastfeeding mothers should consult their doctor before using it.

Elderly Patients

Older adults may be at higher risk for side effects from nabumetone, particularly gastrointestinal bleeding and kidney problems. Careful monitoring and potentially lower doses may be necessary for elderly patients.

Patients with Pre-existing Conditions

People with a history of ulcers, bleeding disorders, heart disease, or liver problems require extra caution when using nabumetone. Close monitoring and dose adjustments may be necessary.

How does nabumetone affect fertility? NSAIDs like nabumetone may temporarily affect ovulation in women, potentially making it harder to conceive. This effect is reversible upon stopping the medication.

Managing Side Effects of Nabumetone

If you experience side effects while taking nabumetone, there are several strategies that may help:

• Take the medication with food to reduce stomach upset
• Use antacids or acid-reducing medications as recommended by your doctor
• Stay well-hydrated to help prevent kidney issues
• Report any unusual symptoms to your healthcare provider promptly
• Consider taking the medication at a different time of day if drowsiness occurs

When should you seek immediate medical attention for side effects? Seek emergency care if you experience signs of a heart attack, stroke, or severe allergic reaction. Also seek prompt medical attention for signs of gastrointestinal bleeding or severe skin reactions.

Long-term Outlook for Patients Taking Nabumetone

For many patients with arthritis, nabumetone can provide effective long-term symptom relief when used as directed. However, it’s important to be aware of the potential risks associated with long-term NSAID use, including cardiovascular and gastrointestinal effects.

Regular follow-ups with your healthcare provider are crucial for monitoring the ongoing benefits and risks of nabumetone therapy. Your treatment plan may need to be adjusted over time based on your response to the medication and any changes in your overall health status.

Can nabumetone slow the progression of arthritis? While nabumetone effectively manages symptoms like pain and inflammation, it does not alter the underlying disease process in conditions like rheumatoid arthritis or osteoarthritis. For this reason, it’s often used in combination with other treatments that may help slow disease progression.

Nabumetone in Comparison to Other Arthritis Treatments

Nabumetone is one of many options available for managing arthritis. Here’s how it compares to some other common treatments:

Nabumetone vs. Other NSAIDs

Nabumetone belongs to the same class of drugs as ibuprofen, naproxen, and celecoxib. While all these medications work similarly to reduce inflammation and pain, they may differ in terms of dosing frequency, side effect profiles, and individual patient response.

Nabumetone vs. Acetaminophen

Unlike nabumetone, acetaminophen (Tylenol) does not have anti-inflammatory properties. It may be less effective for inflammatory conditions like rheumatoid arthritis but can be useful for pain relief in osteoarthritis with less risk of gastrointestinal side effects.

Nabumetone vs. DMARDs

Disease-modifying antirheumatic drugs (DMARDs) like methotrexate or biologics are used primarily in rheumatoid arthritis to slow disease progression. Nabumetone may be used alongside these medications for symptom management.

How do you choose between nabumetone and other arthritis treatments? The choice of treatment depends on various factors including the type and severity of arthritis, individual patient characteristics, and potential side effects. Your healthcare provider will work with you to determine the most appropriate treatment plan.

Practical Tips for Patients Taking Nabumetone

If you’ve been prescribed nabumetone, here are some practical tips to help you use it safely and effectively:

• Keep a medication diary to track your doses and any side effects
• Store nabumetone at room temperature, away from moisture and heat
• If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose
• Avoid drinking alcohol while taking nabumetone
• Use caution when driving or operating machinery, as nabumetone can cause drowsiness
• Inform all healthcare providers, including dentists, that you’re taking nabumetone before any procedures
• Consider wearing a medical alert bracelet indicating you’re taking an NSAID

How can you remember to take nabumetone regularly? Setting a daily alarm on your phone or using a pill organizer can help ensure you don’t miss doses. Taking the medication at the same time each day can also help establish a routine.

Future Directions in Arthritis Treatment

While nabumetone and other current treatments can effectively manage arthritis symptoms, research continues to explore new therapies and approaches. Some areas of ongoing research include:

• Development of more targeted NSAIDs with fewer side effects
• Gene therapy for rheumatoid arthritis
• Stem cell treatments for osteoarthritis
• Personalized medicine approaches to tailor treatments to individual patients
• Novel biologic therapies for autoimmune forms of arthritis

What potential breakthroughs are on the horizon for arthritis treatment? While it’s difficult to predict future developments, researchers are exploring innovative approaches like nanotechnology-based drug delivery systems and regenerative medicine techniques that could revolutionize arthritis treatment in the coming years.

In conclusion, nabumetone can be an effective treatment option for many people with arthritis when used appropriately under medical supervision. By understanding its benefits, risks, and proper usage, patients can make informed decisions about their arthritis management in partnership with their healthcare providers.

Memorial Sloan Kettering Cancer Center

Adult Medication

This information from Lexicomp^® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Relafen DS; Relafen [DSC]

Warning

• This drug may raise the risk of heart and blood vessel problems like heart attack and stroke. These effects can be deadly. The risk may be greater if you have heart disease or risks for heart disease. However, it can also be raised even if you do not have heart disease or risks for heart disease. The risk can happen within the first weeks of using this drug and may be greater with higher doses or long-term use. Do not use this drug right before or after bypass heart surgery.
• This drug may raise the chance of severe and sometimes deadly stomach or bowel problems like ulcers or bleeding. The risk is greater in older people, and in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs.

What is this drug used for?

• It is used to treat some types of arthritis.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have an allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
• If you have gotten nasal polyps or had swelling of the mouth, face, lips, tongue, or throat; unusual hoarseness; or trouble breathing with aspirin or NSAID use.
• If you have any of these health problems: GI (gastrointestinal) bleeding or kidney problems.
• If you have any of these health problems: Heart failure (weak heart) or a recent heart attack.
• If you are taking any other NSAID, a salicylate drug like aspirin, or pemetrexed.
• If you are having trouble getting pregnant or you are having your fertility checked.
• If you are pregnant, plan to become pregnant, or get pregnant while taking this drug. This drug may cause harm to an unborn baby if taken at 20 weeks or later in pregnancy. If you are between 20 to 30 weeks of pregnancy, only take this drug if your doctor has told you to. Do not take this drug if you are more than 30 weeks pregnant.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

• Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
• Have your blood work checked if you are on this drug for a long time. Talk with your doctor.
• High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
• Talk with your doctor before you drink alcohol.
• If you smoke, talk with your doctor.
• If you have asthma, talk with your doctor. You may be more sensitive to this drug.
• Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
• Do not take this drug for longer than you were told by your doctor.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• If you are taking aspirin to help prevent a heart attack, talk with your doctor.
• This drug may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
• The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.
• Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• If you are 65 or older, use this drug with care. You could have more side effects.
• NSAIDs like this drug may affect egg release (ovulation). This may affect being able to get pregnant. This goes back to normal when this drug is stopped. Talk with the doctor.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
• Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Chest pain or pressure.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Feeling very tired or weak.
• Ringing in ears.
• Flu-like signs.
• Severe skin reactions may happen with this drug. These include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions. Sometimes, body organs may also be affected. These reactions can be deadly. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, eyes, genitals, or any areas of skin; fever; chills; body aches; shortness of breath; or swollen glands.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dizziness or headache.
• Constipation, diarrhea, stomach pain, upset stomach, or throwing up.
• Heartburn.
• Gas.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food. Take with food if it causes an upset stomach.
• Take with a full glass of water.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

• Store at room temperature protected from light. Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2022-06-13

Copyright

© 2023 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated

Monday, December 12, 2022

Side Effects, Dosage, Uses, and More

Nabumetone | Side Effects, Dosage, Uses, and More

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Medically reviewed by Femi Aremu, PharmD — By University of Illinois — Updated on August 16, 2021

Highlights for nabumetone

1. Nabumetone oral tablet is only available as a generic drug.
2. Nabumetone only comes as a tablet you take by mouth.
3. Nabumetone oral tablet is used to help reduce pain, inflammation, and swelling caused by osteoarthritis and rheumatoid arthritis.

Nabumetone is a prescription drug. It comes only as an oral tablet.

Nabumetone oral tablet is only available as a generic drug.

Why it’s used

Nabumetone is used to reduce pain, inflammation, and swelling in people with osteoarthritis or rheumatoid arthritis.

How it works

Nabumetone belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

NSAIDs block the production of chemicals in your body that cause inflammation and pain.

NSAIDs help to manage the symptoms of pain, stiffness, inflammation, and swelling caused by osteoarthritis and rheumatoid arthritis.

Nabumetone oral tablet doesn’t cause drowsiness. However, it can cause other side effects.

More common side effects

The more common side effects that can occur with nabumetone include:

• headache
• dizziness
• nausea
• stomach pain
• constipation
• swelling of the hands, feet, and ankles
• mild rash
• ringing in the ears
• sensitivity to the sun

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Heart attack. Symptoms can include:
  • severe chest pain
  • nausea
  • trouble breathing
• Ulcers or bleeding in the stomach or intestines. Symptoms can include:
  • severe stomach pain
• Stroke. Symptoms can include:
  • trouble speaking or thinking
  • weakness on one side of the body
  • blurred vision
• Blood clot. Symptoms can include:
  • cramping or pain in legs
  • coughing
  • trouble breathing
• Heart failure or kidney toxicity. Symptoms can include:
  • weakness
  • coughing
  • swelling
  • unusual weight gain
• Liver toxicity. Symptoms can include:
  • abdominal cramping or pain
  • yellowing of the skin or the whites of the eyes
• Severe allergic reaction. Symptoms can include:
  • trouble breathing
  • sudden or severe rash
• High blood pressure
• Skin reactions. Symptoms can include:
  • red, swollen, blistered, or peeling skin
  • red or irritated eyes
  • sores in your mouth, nose, throat, or eyes

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

Nabumetone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.

Examples of drugs that can cause interactions with nabumetone are listed below.

Drugs you should not use with nabumetone

Do not take these drugs with nabumetone. Doing so can cause dangerous effects in your body. Examples of these drugs include:

• Ketorolac, an anti-inflammatory drug. Using ketorolac with nabumetone increases your risk for bleeding and ulcers.
• Omacetaxine, a chemotherapy drug. Using omacetaxine with nabumetone can increase your risk for bleeding and ulcers.

Interactions that increase your risk for side effects

• Increased side effects from both drugs: Taking nabumetone with certain medications raises your risk for side effects from both drugs. Examples of these drugs include:
  • Warfarin, aspirin, and other NSAIDs such as ibuprofen, naproxen, and celecoxib. Increased side effects can include increased risk of ulcers and bleeding. These drugs should be used cautiously or not at all with nabumetone.
• Increased side effects from other drugs: Taking nabumetone with certain medications raises your risk for side effects from these drugs. Examples of these drugs include:
  • Methotrexate. Increased side effects of methotrexate can include reduction in your white blood cells, red blood cells, and platelets, and a decrease in your body’s ability to fight infections.
  • Lithium. Increased side effects of lithium can include nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, and ringing in your ears.

Interactions that can make your drugs less effective

• When other drugs are less effective: When certain drugs are used with nabumetone, they may not work as well. Examples of these drugs include:
  • Angiotensin-converting enzyme (ACE) inhibitors such as captopril, enalapril, and lisinopril. If you need to take any of these drugs with nabumetone, your doctor may monitor your blood pressure closely.
  • Diuretics (water pills) such as thiazide diuretics (including chlorothiazide and hydrochlorothiazide) and furosemide. If you need to take any of these drugs with nabumetone, your doctor may monitor your fluid levels, blood pressure, and kidney function closely.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Nabumetone oral tablet comes with several warnings.

Allergy warning

People who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) should not take this drug. If you’re not certain about your allergy risk, talk with your doctor or pharmacist.

Warnings for people with certain health conditions

For people with ulcers or gastrointestinal bleeding: Nabumetone may increase risk of ulcers or bleeding from the stomach or intestines. The drug should be used with extreme caution in people with a history of ulcers or bleeding. Risk factors of getting an ulcer or bleeding increases with:

• cigarette smoking
• drinking alcohol
• older adults
• past history of stomach ulcers, or stomach or intestinal bleeding with the use of NSAIDs.

For people with heart disease: Nabumetone can increase the risk of heart attack, stroke, and high blood pressure. It should be used with caution in people with a history of heart disease or those at risk for heart disease. Risk factors for heart disease include:

• high blood pressure
• high cholesterol
• diabetes
• cigarette smoking
• family history of heart disease
• obesity
• being a postmenopausal woman. The risk of heart disease increases after menopause.

For people with heart failure: Nabumetone can increase fluid retention and worsen heart failure.

For people with asthma: People with asthma sometimes have an increased risk of allergic reactions to nabumetone.

Warnings for other groups

For pregnant women: Nabumetone is a pregnancy category C drug. That means two things:

1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
2. There haven’t been enough studies done in humans.

Nabumetone should not be used during pregnancy, especially in late stage pregnancy. If you’re pregnant and need treatment for rheumatoid arthritis or osteoarthritis, talk with your healthcare professional about your treatment options.

Women who are breastfeeding: It’s not known if this drug passes into breast milk. Talk with your doctor about whether you should continue breastfeeding while taking this drug.

For seniors: If you’re an older adult, you may be more likely to have stomach upset or bleeding.

This dosage information is for nabumetone oral tablet. All possible dosages and forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• the severity of your condition
• other medical conditions you have
• how you react to the first dose
• your weight

Forms and strengths

Generic: Nabumetone

• Form: oral tablet
• Strength: 500 mg, 750 mg, 1,000 mg

Dosage for osteoarthritis

Adult dosage (ages 18 years and older)

• Typical starting dosage: 1,000 mg per day. It may be taken once per day or in two divided doses.
• Dosage increases: Your doctor may increase your dosage to 1,500–2,000 mg per day.
• Maximum dosage: 2,000 mg per day.

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in children under the age of 18 years.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

• Typical starting dosage: 1,000 mg per day. It may be taken once a day or in two divided doses.
• Dosage increases: Your doctor may increase your dosage to 1,500–2,000 mg per day.
• Maximum dosage: 2,000 mg per day.

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in children under the age of 18 years.

Special dosage considerations

People with kidney disease generally should not use this drug. Kidney disease can affect the way this drug is processed in the body. Talk with your doctor about your treatment with nabumetone if you have kidney disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Nabumetone oral tablet comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: You risk:

• increasing inflammation and swelling in your joints
• decreasing ability to control your pain

If you miss doses or don’t take the drug on schedule: Not taking nabumetone every day, skipping days, or taking doses at different times of day may increase your risk for inflammation or decrease control of your pain.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• drowsiness
• stomach pain
• trouble breathing
• nausea
• vomiting

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

If you miss a dose: If you miss a dose, just take the next dose as scheduled. Don’t double your dose.

How to tell if the drug is working: Your arthritis pain and swelling should be controlled.

Keep these considerations in mind if your doctor prescribes nabumetone oral tablet for you.

General

• You can take this drug with or without food. However, taking it with food may help decrease nausea.
• The tablet is film coated and should not be cut, crushed, or chewed.

Storage

• Store at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable.You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They won’t damage your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk with your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Last medically reviewed on August 16, 2021

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

• Nabumetone — nabumetone tablet. (2021).
  dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ef7c3da8-797f-4ea9-8999-53509785a0f7&type=display

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

Aug 16, 2021

Medically Reviewed By

Femi Aremu, PharmD

Jun 30, 2018

Written By

University of Illinois-Chicago

Edited By

Yvette Brazier

Copy Edited By

Kim Shaw

VIEW ALL HISTORY

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Medically reviewed by Femi Aremu, PharmD — By University of Illinois — Updated on August 16, 2021

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Description of NABUMETONE indications, dosages, contraindications of the active substance NABUMETONE

Nabumeton – description of the substance, pharmacology, use, contraindications, formula

Contents

• Structural formula

• Russian name

• English name

• Latin name

• chemical name

• Gross formula

• Pharmacological group of the substance Nabumeton

• Nosological classification

• CAS code

• pharmachologic effect

• Characteristic

• Pharmacology

• Application of the substance Nabumeton

• Contraindications

• Application restrictions

• Use during pregnancy and lactation

• Side effects of the substance Nabumeton

• Interaction

• Dosage and administration

Structural formula

Russian name

Nabumeton

English name

Nabumetone

Latin name

Nabumetonum (born 9 0057 Nabumetoni)

Chemical name

4-(6-Methoxy-2-naphthalenyl)- 2-butanone

Gross formula

C ₁₅ H ₁₆ O ₂

Pharmacological group of the substance Nabumeton

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Nosological classification

ICD-10 code list

• M06. 9 Rheumatoid arthritis, unspecified

• M10 Gout

• M13.9 Arthritis, unspecified

• M15-M19 Arthrosis

CAS code

42924-53-8

Pharmacological action

Pharmacological action –

analgesic , antipyretic , anti-inflammatory .

Characteristics

White or colorless crystalline powder. Practically insoluble in water. Soluble in alcohol and most organic solvents.

Pharmacology

The mechanism of action is associated with the blockade of cyclooxygenase, which leads to a violation of the metabolism of arachidonic acid and a decrease in the concentration of PG, thromboxanes. It suppresses exudative and proliferative processes in the focus of inflammation, reduces the concentration of bradykinin and histamine, and also increases the threshold of pain receptor susceptibility. The hypothermic effect is due to a decrease in the concentration of pyrogens in the cerebrospinal fluid and the hypothalamic zone, an increase in heat transfer (it does not affect heat production).

Rapidly and completely absorbed after oral administration. Bioavailability – about 80%. Biotransformed with the formation of an active metabolite (35% of the dose) – 6-methoxy-2-naphthylacetic acid (6-MHA) and 50% of unidentified metabolites. 6-MHA binds to blood proteins by 99%, undergoes terminal transformations in the liver (inactivation). T _1/2 – 24 hours 75% of the dose taken is excreted by the kidneys within 48 hours.

Contraindications

Hypersensitivity, peptic ulcer of the stomach and duodenum, bronchial asthma, nasal polyposis, heart failure, peripheral edema, liver and kidney failure, hemophilia, hypocoagulation conditions.

Restrictions for use

There are no data on the safety of use in pregnant and lactating women, as well as in children.

Pregnancy and Lactation Use

FDA Fetal Category C.

Side effects of the substance Nabumeton

Dyspepsia, NSAID-gastropathy, nausea, vomiting, heartburn, diarrhea, abdominal pain, ulceration of the gastrointestinal mucosa, gastrointestinal bleeding, bronchospasm, heart failure, vasculitis, arrhythmia, arterial hypertension , edema, kidney damage, dizziness, headache, sweating, insomnia, drowsiness, tinnitus, dysuria, hematuria, crystalluria, albuminuria, agranulocytosis, leukopenia, thrombocytopenia, anemia, allergic reactions.