How does trandolapril work in the body. What are the common side effects of trandolapril. When should you not take trandolapril. How should trandolapril be taken for maximum effectiveness. What precautions should be taken while using trandolapril.

Understanding Trandolapril: An ACE Inhibitor for Blood Pressure Management

Trandolapril is a medication belonging to the class of angiotensin-converting enzyme (ACE) inhibitors. It plays a crucial role in managing hypertension and reducing the risk of cardiovascular events in certain patients. This article delves into the various aspects of trandolapril, including its uses, dosage, side effects, and important considerations for patients.

What is Trandolapril?

Trandolapril is primarily used to treat mild-to-moderate high blood pressure. It works by relaxing blood vessels, which allows the heart to pump blood more efficiently throughout the body. Additionally, trandolapril is prescribed to patients who have recently experienced a heart attack to reduce the risk of another cardiac event and prevent the onset or worsening of congestive heart failure.

How Does Trandolapril Work in the Body?

As an ACE inhibitor, trandolapril blocks the action of angiotensin-converting enzyme. This enzyme is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting this conversion, trandolapril helps to:

• Relax and widen blood vessels
• Reduce blood pressure
• Decrease the workload on the heart
• Improve blood flow throughout the body

Trandolapril Dosage and Administration Guidelines

The proper dosage of trandolapril varies depending on the patient’s condition and individual factors. It’s crucial to follow the prescribing physician’s instructions carefully.

Dosage for Hypertension

For treating high blood pressure, the typical starting dose for adults is 1 mg once daily. The dosage may be adjusted every 2 to 4 weeks until blood pressure is adequately controlled. The maximum recommended dose is 4 mg once daily.

Dosage After a Heart Attack

When prescribed after a heart attack, the recommended dosing schedule is as follows:

1. Starting dose: 1 mg once daily, beginning no earlier than the third day after the heart attack
2. After 2 days: Increase to 2 mg once daily
3. After one month: Increase to 4 mg once daily if tolerated

Can trandolapril be taken with or without food? Trandolapril may be taken with or without food, providing flexibility for patients in their daily routine.

Available Forms and Strengths of Trandolapril

Trandolapril is available in various strengths to accommodate different patient needs:

• 0.5 mg capsules
• 1 mg capsules
• 2 mg capsules
• 4 mg capsules

Each strength has specific nonmedicinal ingredients and appearance characteristics to help distinguish between doses.

Common Side Effects and Precautions of Trandolapril

While trandolapril is generally well-tolerated, it’s important for patients to be aware of potential side effects and take necessary precautions.

Common Side Effects

Some of the most frequently reported side effects of trandolapril include:

• Dizziness
• Headache
• Fatigue
• Dry cough
• Nausea
• Low blood pressure

Are there any serious side effects to be aware of? While rare, serious side effects can occur and may include severe allergic reactions, kidney problems, or changes in blood cell counts. Patients should seek immediate medical attention if they experience symptoms such as difficulty breathing, swelling of the face or throat, or unusual bleeding or bruising.

Precautions and Contraindications

Trandolapril may not be suitable for everyone. It’s important to inform your healthcare provider about any existing medical conditions or medications you’re taking. Trandolapril is contraindicated in the following situations:

• Known allergy to trandolapril or other ACE inhibitors
• History of angioedema related to previous ACE inhibitor therapy
• Pregnancy (especially in the second and third trimesters)
• Concomitant use with aliskiren in patients with diabetes or moderate to severe kidney impairment

Drug Interactions and Special Considerations

Trandolapril can interact with various medications and substances, potentially affecting its efficacy or increasing the risk of side effects.

Common Drug Interactions

Patients should be cautious when taking trandolapril with the following:

• Potassium supplements or potassium-sparing diuretics
• Lithium
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Other blood pressure medications
• Certain diabetes medications

How can patients minimize the risk of drug interactions? It’s crucial to provide a complete list of all medications, supplements, and herbal products to your healthcare provider before starting trandolapril.

Special Populations

Certain groups of patients may require special consideration when taking trandolapril:

• Elderly patients: May be more sensitive to the effects of trandolapril
• Patients with kidney or liver impairment: May require dose adjustments
• Patients undergoing dialysis: Trandolapril may not be suitable
• Patients with a history of angioedema: Increased risk of recurrence

Monitoring and Follow-up While Taking Trandolapril

Regular monitoring is essential for patients taking trandolapril to ensure its effectiveness and detect any potential issues early.

Blood Pressure Monitoring

Patients should have their blood pressure checked regularly, especially during the initial period of treatment and after any dose adjustments.

Laboratory Tests

Healthcare providers may recommend periodic blood tests to monitor:

• Kidney function
• Electrolyte levels (particularly potassium)
• Blood cell counts

How often should patients have follow-up appointments? The frequency of follow-up appointments will depend on individual factors, but typically, patients should see their healthcare provider at least once every 3-6 months or as recommended.

Lifestyle Modifications to Complement Trandolapril Treatment

While trandolapril is effective in managing blood pressure, combining medication with lifestyle changes can enhance its benefits and improve overall cardiovascular health.

Dietary Recommendations

Patients taking trandolapril should consider the following dietary modifications:

• Reduce sodium intake
• Increase consumption of fruits, vegetables, and whole grains
• Limit alcohol consumption
• Maintain a balanced diet rich in potassium, magnesium, and calcium

Exercise and Physical Activity

Regular physical activity can complement the effects of trandolapril in managing blood pressure. Patients should aim for:

• At least 150 minutes of moderate-intensity aerobic exercise per week
• Strength training exercises 2-3 times per week
• Consistency in their exercise routine

What precautions should be taken when exercising while on trandolapril? Patients should start slowly and gradually increase the intensity of their workouts. It’s also important to stay hydrated and be aware of any dizziness or lightheadedness, especially during the initial stages of treatment.

Stress Management

Chronic stress can negatively impact blood pressure. Patients can incorporate stress-reduction techniques such as:

• Meditation or mindfulness practices
• Deep breathing exercises
• Yoga or tai chi
• Regular relaxation time

Long-term Considerations for Trandolapril Use

Patients prescribed trandolapril for long-term use should be aware of certain considerations to ensure safe and effective treatment.

Adherence to Medication Schedule

Consistent adherence to the prescribed trandolapril regimen is crucial for maintaining its therapeutic effects. Patients should:

• Take trandolapril at the same time each day
• Use pill organizers or reminders if needed
• Never abruptly stop taking the medication without consulting their healthcare provider

Managing Missed Doses

If a dose is missed, patients should take it as soon as they remember. However, if it’s close to the time for the next dose, they should skip the missed dose and continue with their regular schedule. Double dosing should be avoided.

Long-term Side Effect Monitoring

While many side effects of trandolapril occur early in treatment, some may develop over time. Patients should be vigilant for:

• Changes in kidney function
• Persistent dry cough
• Unexplained swelling or weight gain
• Any new or worsening symptoms

How often should patients have their kidney function checked while on long-term trandolapril therapy? Typically, kidney function should be assessed at least annually, or more frequently if the patient has pre-existing kidney issues or is at higher risk for complications.

Pregnancy and Breastfeeding Considerations

Trandolapril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Women of childbearing age should use effective contraception while taking trandolapril and inform their healthcare provider immediately if they become pregnant or plan to become pregnant.

Regarding breastfeeding, limited data suggest that trandolapril may be present in breast milk. The decision to continue or discontinue breastfeeding while taking trandolapril should be made in consultation with a healthcare provider, considering the benefits of breastfeeding and the importance of the medication for the mother’s health.

Potential Alternatives to Trandolapril

While trandolapril is effective for many patients, some may require alternative treatments due to side effects, contraindications, or personal preferences.

Other ACE Inhibitors

If trandolapril is not well-tolerated, other ACE inhibitors may be considered, such as:

• Lisinopril
• Enalapril
• Ramipril
• Perindopril

Alternative Antihypertensive Medications

Other classes of blood pressure medications that may be used as alternatives or in combination with trandolapril include:

• Angiotensin II receptor blockers (ARBs)
• Calcium channel blockers
• Beta-blockers
• Diuretics

What factors determine the choice of alternative medications? The selection of alternative medications depends on various factors, including the patient’s overall health, comorbidities, potential drug interactions, and individual response to treatment.

Non-pharmacological Approaches

In some cases, lifestyle modifications alone may be sufficient to manage mild hypertension. These approaches include:

• Dietary changes (e.g., DASH diet)
• Regular exercise
• Weight management
• Stress reduction techniques
• Limiting alcohol and caffeine intake

Trandolapril is a valuable medication in the management of hypertension and cardiovascular risk reduction. By understanding its uses, potential side effects, and important considerations, patients can work closely with their healthcare providers to optimize their treatment and maintain their cardiovascular health. Regular monitoring, adherence to prescribed regimens, and open communication with healthcare professionals are key to achieving the best outcomes with trandolapril therapy.

pms-Trandolapril – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Trandolapril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It is used to treat mild-to-moderate high blood pressure. It works by relaxing blood vessels, allowing the heart to pump more efficiently. It is also used after heart attacks to reduce the risk of another heart attack and prevent the onset or worsening of congestive heart failure.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.  If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

0.5 mg
Each opaque, hard gelatin, Coni-Snap®, size No. 3 capsule, ink-printed in black with “T 0.5 mg” in radial position on the red body, nothing on the yellow cap, and filled with white-to-off-white powder, contains 0.5 mg of trandolapril. Nonmedicinal ingredients: colloidal silicon dioxide, dimeticone, lactose, magnesium stearate, microcrystalline cellulose, starch maize, and gelatin capsules; shell cap: black iron oxide, red iron oxide, yellow iron oxide, titanium dioxide, and gelatin; shell body: erythrosine FD&C Red No.  3, Sunset Yellow FCF-FD&C Yellow No. 6, titanium dioxide, and gelatin.

1 mg
Each opaque, hard gelatin, Coni-Snap®, size No. 3 capsule, ink-printed in black with “T1 mg” in radial position on the red body, nothing on the orange cap, and filled with white-to-off-white powder, contains 1 mg of trandolapril. Nonmedicinal ingredients: colloidal silicon dioxide, dimeticone, lactose, magnesium stearate, microcrystalline cellulose, starch maize, and gelatin capsules; shell cap: erythrosine FD&C Red No. 3, quinoline yellow, titanium dioxide, and gelatin; shell body: erythrosine FD&C Red No. 3, sunset yellow FCF-FD&C Yellow No. 6, titanium dioxide, and gelatin.

2 mg
Each opaque, hard gelatin, Coni-Snap®, size No. 3 capsule, ink-printed in black with “T 2 mg” in radial position on the red body, nothing on the red cap, and filled with white-to-off-white powder, contains 2 mg of trandolapril. Nonmedicinal ingredients: colloidal silicon dioxide, dimeticone, lactose, magnesium stearate, microcrystalline cellulose, starch maize, and gelatin capsules; shell cap: erythrosine FD&C Red No.  3, sunset yellow FCF-FD&C Yellow No. 6, titanium dioxide, and gelatin; shell body: erythrosine FD&C Red No. 3, sunset yellow FCF-FD&C Yellow No. 6, titanium dioxide, and gelatin.

4 mg
Each opaque, hard gelatin, Coni-Snap®, size No. 2 capsule, ink-printed in black with “T 4 mg” in radial position on the red body, nothing on the brown cap, and filled with white-to-off-white powder, contains 4 mg of trandolapril. Nonmedicinal ingredients: colloidal silicon dioxide, dimeticone, lactose, magnesium stearate, microcrystalline cellulose, starch maize and gelatin capsules; shell cap: erythrosine FD&C Red No. 3, Indigo Carmine-FD&C Blue No. 2, titanium dioxide, and gelatin; shell body: erythrosine FD&C Red No. 3, sunset yellow FCF-FD&C Yellow No. 6, titanium dioxide, and gelatin.

How should I use this medication?

For treatment of high blood pressure, the recommended adult starting dose is 1 mg once daily with increases in dose every 2 to 4 weeks until blood pressure is controlled. The maximum recommended dose is 4 mg once daily. After a heart attack, the recommended starting dose is 1 mg once daily starting no earlier than the third day after the heart attack has taken place. After 2 days, the recommended dose is increased to 2 mg once daily and after one month, the recommended dose is increased to 4 mg once daily if the medication is tolerated.

Trandolapril may be taken with or without food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.  Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take trandolapril if you:

• are allergic to trandolapril or any ingredients of the medication
• are allergic to any other ACE inhibitors
• are pregnant or plan to become pregnant
• are breast-feeding
• are taking the medication sacubitril – valsartan
• are taking the medication aliskiren or another ACE inhibitor or an angiotensin receptor blocker (ARB) and have one of the following conditions:
• diabetes
• kidney disease
• high levels of potassium in the blood
• have congestive heart failure combined with low blood pressure
• have been diagnosed with hereditary angioedema
• have severely low blood pressure
• have any condition that makes you intolerant to lactose
• have had angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any other ACE inhibitors (e. g., captopril, ramipril)
• have narrowing of the blood vessels in the kidneys

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• cough (dry, persistent)
• diarrhea
• dizziness
• fatigue
• headache
• loss of appetite
• nasal stuffiness
• nausea
• unusual tiredness
• vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• confusion
• flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
• numbness or tingling in hands, feet, or lips
• signs of bleeding (e.g., unusual nosebleeds, blood in urine, coughing blood, bruising easily, cuts that won’t stop bleeding)
• signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• signs of fluid and electrolyte imbalance (e.g., drowsiness, muscle pain or cramps, weakness, irregular heartbeat)
• signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs of liver problems (e. g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of low blood pressure (e.g., dizziness, lightheadedness, fainting)
• signs of too much potassium in the body (e.g., confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs)
• skin rash, with or without itching, fever, or joint pain

Stop taking the medication and seek immediate medical attention if any of the following occur:

• abdominal pain, with or without nausea or vomiting
• signs of angioedema (e.g., swollen mouth, lips, tongue, difficulty swallowing or breathing)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed.  Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Angioedema: Angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) may occur with trandolapril, although uncommonly. Angioedema may also affect the digestive system. If swelling of the face, tongue, or glottis occurs, or you experience unexpected abdominal pain that may be accompanied by nausea or vomiting, stop the medication at once and seek immediate medical attention. If you experience angioedema with trandolapril, you should not take any of the other ACE inhibitors, such as enalapril, lisinopril, or quinapril.

People who have had angioedema caused by other substances may be at increased risk of angioedema while taking an ACE inhibitor such as trandolapril.

Blood disorders: In rare cases, a low white blood cell count has been reported by people taking this medication. Your doctor may occasionally monitor your level of white blood cells by performing blood tests. Low white blood cell levels may increase your risk for infection. If you notice any signs of infection (e.g., fever, sore throat), contact your doctor as soon as possible.

Cough: People taking trandolapril may develop a dry, persistent cough that usually disappears only after stopping or lowering the trandolapril dose. Be sure to tell your doctor of any cough which does not seem to be related to a usual cause.

Dizziness/reduced alertness: Trandolapril can cause side effects such as dizziness, drowsiness, headache or fatigue that may reduce alertness, especially when you first start to take this medication. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by this medication.

Fluid and electrolyte balance: Increases in blood levels of potassium may occur as a result of taking trandolapril. This rarely causes problems, but your doctor will probably want to monitor your potassium levels regularly with blood tests. If you experience unexplained nausea, fatigue, muscle weakness, or tingling sensations, contact your doctor.

Kidney function: Certain people who take this medication may experience changes in kidney function. Some people may be more likely to experience changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), aliskiren, or nonsteroidal anti-inflammatory drugs (NSAIDs), may further increase risk of kidney problems for those at risk for this problem. If you have kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

This medication may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, blood pressure drops too low after taking trandolapril. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur for those who take aliskiren, water pills, have a salt restricted diet, are on dialysis, or are experiencing diarrhea or vomiting. These individuals should be monitored closely by their doctor for the first weeks of treatment and whenever the dose of the medication is increased. To reduce the risk of dizziness, get up slowly from a lying down or sitting position. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Excessive sweating and lack of fluid intake may lead to an excessive fall in blood pressure because of reduced fluid in your blood vessels. Vomiting or diarrhea may also lead to a fall in blood pressure. Consult your doctor if you feel your blood pressure is too low.

Pregnancy: ACE inhibitors such as trandolapril may cause severe harm or death to a developing baby if taken by the mother during pregnancy. This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking trandolapril, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors may have an increased risk of experiencing side effects when taking trandolapril due to reduced kidney function. Lower doses may be necessary to minimize side effects.

What other drugs could interact with this medication?

There may be an interaction between trandolapril and any of the following:

• acetylsalicylic acid (ASA)
• alcohol
• aldesleukin
• aliskiren
• allopurinol
• alpha-agonists (e.g., clonidine, methyldopa)
• alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
• amifostine
• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
• angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
• angiotensin II receptor blockers (ARBs; e. g., candesartan, irbesartan, losartan)
• antacids (e.g., calcium carbonate, magnesium hydroxide)
• azathioprine
• barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• brimonidine
• calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
• cyclosporine
• dexmethylphenidate
• diabetes medications (e.g., canagliflozin, chlorpropamide, glipizide, glyburide, insulin, metformin,  rosiglitazone)
• diazoxide
• dipyridamole
• diuretics (water pills; e.g., furosemide, amiloride, spironolactone, triamterene)
• drospirenone
• duloxetine
• eplerenone
• everolimus
• gold salts
• grass pollen allergen extract
• guanfacine
• heparin
• iron dextran
• iron gluconate
• levodopa
• lithium
• low molecular weight heparins (e. g., dalteparin, enoxaparin, tinzaparin)
• medications that increase blood levels of potassium (e.g., potassium chloride, salt substitutes containing potassium)
• medications that lower blood pressure
• methylphenidate
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., indomethacin)
• obinutuzumab
• pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
• pregabalin
• sacubitril
• second generation anti-psychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
• sirolimus
• sodium phosphates
• tacrolimus
• temsirolimus
• tizanidine
• tolvaptan
• trimethoprim
• yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/pms-Trandolapril

Memorial Sloan Kettering Cancer Center

Adult Medication

This information from Lexicomp^® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: Canada

APO-Trandolapril; AURO-Trandolapril; Mavik; Odrik; PMS-Trandolapril; SANDOZ Trandolapril; TEVA-Trandolapril

Warning

• Do not take if you are pregnant. Use during pregnancy may cause birth defects or loss of the unborn baby. If you get pregnant or plan on getting pregnant while taking this drug, call your doctor right away.

What is this drug used for?

• It is used to treat high blood pressure.
• It is used to help heart function after a heart attack.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have ever had a very bad or life-threatening reaction called angioedema. Signs may be swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; unusual hoarseness.
• If you are taking a drug that has aliskiren in it and you also have diabetes or kidney problems.
• If you have taken a drug that has sacubitril in it in the last 36 hours.
• If you are breast-feeding. Do not breast-feed while you take this drug.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

• Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• Check your blood pressure as you have been told.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
• If you are on a low-salt or salt-free diet, talk with your doctor.
• Low white blood cell counts have happened with captopril, a drug like this one. This may lead to more chance of getting an infection. Most of the time, this has happened in people with kidney problems, mainly if they have certain other health problems. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
• If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and some natural products or aids.
• Talk with your doctor before you drink alcohol.
• Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
• Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. This may lead to low blood pressure.
• This drug may not work as well to lower blood pressure in Black patients. Sometimes another drug may need to be given with this drug. If you have any questions, talk with the doctor.
• A severe and sometimes deadly reaction called angioedema has happened. The chance of angioedema may be higher in Black patients.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
• Very bad dizziness or passing out.
• Severe stomach pain.
• Very upset stomach or throwing up.
• Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Cough.
• Dizziness.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take this drug at the same time of day.
• Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

• Store at room temperature in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2020-06-04

Copyright

© 2023 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated

Monday, December 12, 2022

Description TRANDOLAPRIL indications, dosages, contraindications of the active ingredient TRANDOLAPRIL

instructions for use, description, reviews of patients and doctors, analogues

Some facts about the product:

Instructions for use

Description

Gopten is one of the angiotensin-converting enzyme inhibitors. Has a hypotensive effect. You can buy Gopten in our online pharmacy with delivery to the specified address in Russia. Our Gopten price is affordable. Before buying and starting to use the drug, be sure to read the instructions for its use, indications and contraindications for taking, side effects, composition, dosage regimen and other necessary information. You can purchase Gopten in Moscow and other regions.

Pharmacological action

The antihypertensive effect of the drug is based on its structural component trandolapril. It is one of the drugs that lower blood pressure by suppressing the formation of angiotensin type 2 and dilating blood vessels. A single oral dose of two milligrams of trandolapril per day contributes to a pronounced normalization of blood pressure and heart rate within two days. The drug is eighty percent bound to plasma proteins. It is excreted from the body unchanged in the urine.

Presentation, composition and packaging

Gopten is produced and sold in the dosage form of capsules. Capsules are placed in aluminum blisters with a capacity of fourteen pieces. There are two such blisters in a carton box, which corresponds to twenty-eight capsules in a pack. One capsule contains two milligrams of trandolapril, supplemented with such auxiliary components as corn starch, povidone, lactose monohydrate, titanium dioxide, gelatin and sodium lauryl sulfate. Capsules have a reddish tint and an oblong oval shape. Inside are white granules. The manufacturer of the drug is the German pharmaceutical company Abbvi Deutschland GmbH.

Readings

The drug is used to eliminate the symptoms of hypertension and mild to moderate arterial hypertension. Helps to normalize blood pressure, stabilize the heart rate, eliminate pain. The drug is also used to normalize the patient’s condition and eliminate dysfunctions of the left ventricle after a myocardial infarction. The drug can be used both as a monotherapeutic drug and as part of a combination therapy for pathologies along with thiazide diuretics. It is taken only on doctor’s orders.

Contraindications

The drug is not recommended for use if the patient has an increased susceptibility to trandolapril and any other components of the drug. Reception should be limited if a patient has a narrowing of the mitral and aortic valves, hypertrophic cardiomyopathy, and dysfunction of the heart muscle. It is not prescribed for people under the age of eighteen due to insufficient knowledge of the effect of trandolapril on their body. The appointment is not recommended for pregnant women and during breastfeeding of the baby due to the possible toxic effect of the drug on the child’s body.

Dosage and administration

The drug is recommended for oral administration by swallowing the capsule with the medicinal substance without chewing. It is taken regardless of the time of eating. It is initially prescribed at a dosage of two milligrams at one time per day. After two weeks, the dose may be increased according to the doctor’s recommendation. With dysfunctions of the kidneys and liver, trandolapril is taken at 0.5 milligrams at a time, but not more than two milligrams per day. Trandolapril treatment of patients with chronic heart failure and malignant hypertension is carried out in a stationary mode.

Side effects

There is a description of side effects after taking Gopten. Most often, a pronounced decrease in blood pressure was recorded (especially when combined with diuretics), dizziness, cough, instability of heart rhythms, nausea, vomiting, headache, changes in blood composition. The drug can lead to an increase in the concentration of creatinine and uric acid in the body. If the patient is allergic to trandolapril, rashes and redness on the skin, itching, urticaria, joint pain appear. If the side effects do not go away for several days, you should stop taking the medicine and seek help from a doctor.

Drug interactions

The antihypertensive effect of trandolapril is reduced when it is used in combination with acetylsalicylic acid, indomethacin and other analgesics. Combination with amiloride, spironolactone and triamterene can cause a pronounced increase in the content of potassium in the body. A significant decrease in blood pressure is observed while taking trandolapril with sleeping pills. The combination with immunosuppressants increases the risk of a decrease in the content of leukocytes in the blood. Any drug interactions must be pre-agreed with the doctor and approved by him.

Special instructions

A pronounced decrease in blood pressure is possible at the beginning of trandolapril therapy, when the body is just getting used to the action of this substance. The presence of an allergic reaction may be accompanied by angioedema, although this is more typical for representatives of the Negroid race. With a decrease in the creatinine index to a level below ten milliliters per minute, you should stop taking the drug. It is necessary to constantly monitor this indicator. It is better to refrain from driving a car and other vehicles during treatment, as the drug may cause drowsiness.