Use of methyl salicylate. Methyl Salicylate-Menthol Topical: Uses, Side Effects, and Dosing Guide
What are the uses of methyl salicylate-menthol topical. How should this medication be applied. What are the potential side effects and precautions to be aware of. When should you seek medical attention while using this topical treatment.
Understanding Methyl Salicylate-Menthol Topical: An Overview
Methyl salicylate-menthol topical is a widely used over-the-counter medication for temporary relief of minor aches and pains. This topical treatment combines the analgesic properties of methyl salicylate with the cooling sensation of menthol to provide localized pain relief. It’s commonly found in various forms, including creams, gels, patches, and sprays.
The active ingredients in this topical medication work together to alleviate discomfort associated with various conditions. Methyl salicylate, a chemical cousin of aspirin, helps reduce inflammation and pain when applied to the skin. Menthol, on the other hand, creates a cooling sensation that can help distract from pain signals and provide a soothing effect.

Common Uses and Applications of Methyl Salicylate-Menthol Topical
This topical treatment is versatile and can be used for a variety of minor aches and pains. Some common applications include:
- Strains and sprains
- Arthritis pain
- Bruising
- Nerve pain
- Simple backache
- Lower spine pain
Is methyl salicylate-menthol topical effective for all types of pain. While it can provide relief for many minor aches, it’s important to note that this medication is not intended for severe or chronic pain conditions. For persistent or intense pain, it’s crucial to consult with a healthcare professional for proper diagnosis and treatment.
Proper Application and Dosage Instructions
To ensure safe and effective use of methyl salicylate-menthol topical, it’s essential to follow the proper application instructions:
- Clean and dry the affected area thoroughly before application.
- Apply a thin layer of the medication to the painful area.
- Gently rub the product into the skin.
- Wash your hands with soap and water after application, unless treating an area on the hands.
- Avoid covering the treated area with a bandage or heating pad.
How often can methyl salicylate-menthol topical be applied. The frequency of application can vary depending on the specific product and formulation. Generally, it can be used up to 3-4 times daily, but it’s crucial to carefully read and follow the instructions on the product label or as directed by a healthcare provider.

Special Considerations for Different Formulations
Different formulations of methyl salicylate-menthol topical may have specific application instructions:
- Patches: Apply the patch over the area of pain and press the edges firmly. Remove and replace as directed on the product label.
- Sprays: Shake well before each use and apply as directed, typically holding the container 6-8 inches from the skin.
- Sticks: Apply directly to the affected area, being careful not to apply too much pressure.
Potential Side Effects and Precautions
While methyl salicylate-menthol topical is generally safe when used as directed, it’s important to be aware of potential side effects and take necessary precautions:
Common Side Effects
- Mild skin irritation
- Redness at the application site
- Burning or tingling sensation
Serious Side Effects
In rare cases, more serious side effects may occur. Seek immediate medical attention if you experience:
- Severe skin irritation or rash
- Signs of an allergic reaction (hives, difficulty breathing, swelling of face, lips, tongue, or throat)
- Increased pain or significant redness and swelling of the treated area
Can methyl salicylate-menthol topical cause systemic side effects. While rare, excessive use or application over large areas of skin can potentially lead to systemic absorption, which may cause symptoms similar to aspirin toxicity. It’s crucial to use the product only as directed and avoid applying it to damaged or irritated skin.

Important Warnings and Contraindications
Before using methyl salicylate-menthol topical, it’s essential to be aware of certain warnings and contraindications:
- Do not use on open wounds, blistered, sunburned, or otherwise irritated skin.
- Avoid applying to mucous membranes or sensitive areas of the body.
- Do not use with tight bandages or heating pads, as this may increase the risk of side effects.
- Consult a healthcare provider before use if you have a history of allergies, especially to aspirin or other salicylates.
- Exercise caution when using during pregnancy or while breastfeeding.
Is it safe to use methyl salicylate-menthol topical on children. Some formulations are approved for use in children, but it’s crucial to consult with a pediatrician or healthcare provider before applying this medication to a child. Always follow age-specific guidelines provided on the product label.
Drug Interactions and Special Considerations
While methyl salicylate-menthol topical is applied externally, it’s important to be aware of potential drug interactions and special considerations:

Potential Drug Interactions
- Blood thinners (e.g., warfarin)
- Oral salicylates (e.g., aspirin)
- Certain diabetes medications
Always inform your healthcare provider about all medications you’re using, including topical treatments, to avoid potential interactions.
Special Populations
Extra caution should be exercised when using methyl salicylate-menthol topical in certain populations:
- Elderly: May be more sensitive to side effects
- Pregnant women: Consult a healthcare provider before use
- Breastfeeding mothers: Avoid applying to nipple area
- Individuals with aspirin sensitivity or allergies
How does methyl salicylate-menthol topical affect the skin’s absorption of other medications. This topical treatment may potentially increase the skin’s absorption of other topical medications. It’s advisable to consult with a healthcare provider or pharmacist before using multiple topical treatments concurrently.
Proper Storage and Disposal of Methyl Salicylate-Menthol Topical
To maintain the effectiveness and safety of methyl salicylate-menthol topical, proper storage and disposal are essential:

Storage Guidelines
- Store at room temperature, away from moisture and heat
- Keep out of direct sunlight
- Ensure the container is tightly closed when not in use
- Keep out of reach of children and pets
Disposal Recommendations
When disposing of unused or expired methyl salicylate-menthol topical:
- Do not flush down the toilet or pour down the drain
- Check with your local pharmacy or waste management authority for proper disposal methods
- Consider participating in medication take-back programs if available in your area
How long can methyl salicylate-menthol topical be stored after opening. The shelf life after opening can vary depending on the specific product and formulation. Generally, it’s best to use the product within 6-12 months of opening or by the expiration date printed on the package, whichever comes first.
When to Seek Medical Attention
While methyl salicylate-menthol topical is generally safe for short-term use, there are situations where medical attention should be sought:

- If pain persists or worsens after 7 days of use
- If you experience severe skin irritation or signs of an allergic reaction
- If you accidentally ingest the product
- If you develop unexplained symptoms while using the medication
Is it necessary to consult a healthcare provider before using methyl salicylate-menthol topical for chronic pain conditions. Yes, for chronic pain conditions or if you plan to use the product for an extended period, it’s advisable to consult with a healthcare provider. They can assess your condition and determine if this topical treatment is appropriate or if alternative therapies may be more beneficial.
Alternative Pain Relief Options
While methyl salicylate-menthol topical can be effective for many minor aches and pains, there are alternative options to consider:
Other Topical Treatments
- Capsaicin creams
- Lidocaine patches
- Diclofenac gels
Non-Pharmacological Approaches
- Physical therapy
- Acupuncture
- Massage therapy
- Heat or cold therapy
Oral Medications
- Over-the-counter pain relievers (e.g., ibuprofen, acetaminophen)
- Prescription pain medications (for more severe pain, under medical supervision)
How does the effectiveness of methyl salicylate-menthol topical compare to other pain relief options. The efficacy can vary depending on the individual and the specific condition being treated. For some, topical treatments like methyl salicylate-menthol may provide sufficient relief, while others may require a combination of approaches or different treatment modalities. It’s always best to consult with a healthcare provider to determine the most appropriate pain management strategy for your specific situation.

In conclusion, methyl salicylate-menthol topical offers a convenient and often effective option for managing minor aches and pains. By understanding its proper use, potential side effects, and important precautions, you can maximize its benefits while minimizing risks. Remember to always follow the product instructions carefully and consult with a healthcare provider if you have any concerns or questions about using this medication.
Methyl salicylate topical Uses, Side Effects & Warnings
Generic name: methyl salicylate topical [ METH-il-sa-LISS-il-ate-TOP-ik-al ]
Brand names: BENGAY Arthritis, Boroleum, Castiva Cooling, Eucalyptamint, Exocaine Plus,
… show all 53 brands
Gordogesic, Heet Triple Action, Icy Hot, Salonpas Pain Patch, Satogesic, Thera-Gesic, Absorbine Jr., Wintergreen Oil, BENGAY Ultra, Analgesic Balm, Menthol C, Arthricare Cream, BENGAY Original, Salonpas Pain Gel, Salonpas Pain Spray, Banalg, Heet Analgesic Liniment, Mentholatum Pain Patch, Mentholatum Pain Gel, Penetran Pain Relieving, Satogesic Pad, Satogesic Hot Gel, Deep Down Pain Relief, Nephro-Derm, Cooling Gel, Absorbine Jr. Extra Strength, Ben Gay, Vaporizing Cold Rub, Flex-All 454, Pain Stick Arthritis Formula, Pain Stick Sports Formula, Minit Rub, Thera-P Blue, Analgesic Balm Greaseless, BENGAY Vanishing Scent, Banalg Hospital Strength, Panalgesic Gold, Therapeutic Pain Relief, Cold and Hot Pain Relief, Thera-Gesic Extra Plus, PainZone, duraflex comfort, Salonpas Pain Relief Patch, Salonpas Arthritis Pain, Precise Pain Relieving, Ultra Strength Muscle Rub, Aloe Vera Liniment, Coats Aloe Analgesic Liniment
Dosage forms: topical cream (-), topical film (-), topical gel (-), topical liquid (-), topical lotion (-), topical oil (-), topical ointment (-),
.
.. show all 9 dosage forms
topical spray (-), topical stick (-)
Drug class: Topical rubefacient
Medically reviewed by Drugs.com on Dec 15, 2021. Written by Cerner Multum.
What is methyl salicylate topical?
Methyl salicylate topical (for the skin) is used for temporary relief of minor aches and pains caused by strains, sprains, arthritis, bruising, nerve pain, simple backache, or pain in the lower spine.
Methyl salicylate topical may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on the label and package. Use exactly as directed.
Before taking this medicine
Ask a doctor or pharmacist if methyl salicylate topical is safe to use if you have ever had an allergy (especially to aspirin or other salicylates).
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
If you breastfeed, avoid applying this medicine to your nipple area.
Do not use this medicine on a child without medical advice.
How should I use methyl salicylate topical?
Use exactly as directed on the label, or as prescribed by your doctor.
Do not take by mouth. Topical medicine is for use only on the skin.
Apply only to clean and dry skin. Avoid applying over large areas of skin.
Do not apply to an open wound or to skin that is blistered, sunburned, windburned, otherwise irritated.
Only certain forms of this medicine are for use in young children. Follow all directions when using this medicine on a child.
Apply a thin layer of medicine to the painful area and rub in gently.
Apply the skin patch over the area of pain and press the edges firmly. Remove the patch and apply a new one as directed.
Shake the spray well just before each use.
Wash your hands with soap and water after applying this medicine or handling a skin patch. To keep from getting this medicine on your fingers, apply it using a rubber glove, finger cot, cotton ball, or clean tissue.![]()
If using the medicine to treat an area of your hands or fingers, wait at least 30 minutes before washing your hands.
Do not cover treated skin with a bandage or heating pad.
Stop using this medicine and call your doctor if your pain does not improve after 7 days, or if your symptoms get worse or get better and then come back in a few days.
Store at room temperature away from moisture, heat, and direct sunlight.
What happens if I miss a dose?
Methyl salicylate topical is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.
What should I avoid while using methyl salicylate topical?
Avoid getting methyl salicylate topical in your eyes. If contact does occur, rinse with water. Also avoid getting the medicine in your nose, mouth, rectum, or vagina.
Also avoid getting the medicine on contact lenses, dentures, and other items that come in contact with sensitive areas of your body.
Avoid using other medications on the same treatment areas without medical advice.
Methyl salicylate topical side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:
redness or swelling of the treated area;
increased pain; or
severe burning or skin irritation such as a rash, itching, pain, or blistering.
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect methyl salicylate topical?
Medicine used on the skin is not likely to be affected by other drugs you use, but many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.
More about methyl salicylate topical
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- Drug class: topical rubefacient
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Other brands
Salonpas Pain Patch, Eucalyptamint, Boroleum, Castiva Cooling, … +5 more
Related treatment guides
- Osteoarthritis
- Muscle Pain
- Rheumatoid Arthritis
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.![]()
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Copyright 1996-2023 Cerner Multum, Inc. Version: 3.02.
Methyl Salicylate Topical (Icy Hot)
Brand Names:Absorbine Jr., Absorbine Jr. Extra Strength, Aloe Vera Liniment, Analgesic Balm, Analgesic Balm Greaseless, Arthricare Cream
Reviewed:
Methyl salicylate topical (for the skin) is used for temporary relief of minor aches and pains caused by strains, sprains, arthritis, bruising, nerve pain, simple backache, or pain in the lower spine.
Methyl salicylate topical may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Methyl Salicylate Topical (Icy Hot)?
Ask a doctor or pharmacist if this medicine is safe to use if you have ever had an allergy (especially to aspirin or other salicylates).
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
If you breastfeed, avoid applying this medicine to your nipple area.
Do not use this medicine on a child without medical advice.
Side Effects
What are the side effects of Methyl Salicylate Topical (Icy Hot)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
- redness or swelling of the treated area;
- increased pain; or
- severe burning or skin irritation such as a rash, itching, pain, or blistering.
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Methyl Salicylate Topical (Icy Hot) if I’m pregnant or breastfeeding?
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
If you breastfeed, avoid applying this medicine to your nipple area.
Interactions
What drugs and food should I avoid while taking Methyl Salicylate Topical (Icy Hot)?
Avoid getting this medicine in your eyes. If contact does occur, rinse with water. Also avoid getting the medicine in your nose, mouth, rectum, or vagina.
Also avoid getting the medicine on contact lenses, dentures, and other items that come in contact with sensitive areas of your body.
Avoid using other medications on the same treatment areas without medical advice.
Dosage Guidelines & Tips
How to take Methyl Salicylate Topical (Icy Hot)?
Use Methyl Salicylate Topical (Icy Hot) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Use exactly as directed on the label, or as prescribed by your doctor.
Do not take by mouth. Topical medicine is for use only on the skin.
Apply only to clean and dry skin. Avoid applying over large areas of skin.
Do not apply to an open wound or to skin that is blistered, sunburned, windburned, otherwise irritated.
Only certain forms of this medicine are for use in young children. Follow all directions when using this medicine on a child.
Apply a thin layer of medicine to the painful area and rub in gently.
Apply the skin patch over the area of pain and press the edges firmly. Remove the patch and apply a new one as directed.
Shake the spray well just before each use.
Wash your hands with soap and water after applying this medicine or handling a skin patch. To keep from getting this medicine on your fingers, apply it using a rubber glove, finger cot, cotton ball, or clean tissue.
If using the medicine to treat an area of your hands or fingers, wait at least 30 minutes before washing your hands.
Do not cover treated skin with a bandage or heating pad.
Stop using this medicine and call your doctor if your pain does not improve after 7 days, or if your symptoms get worse or get better and then come back in a few days.
Store at room temperature away from moisture, heat, and direct sunlight.
What should I do if I missed a dose of Methyl Salicylate Topical (Icy Hot)?
Methyl salicylate topical is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.
Overdose Signs
What happens if I overdose on Methyl Salicylate Topical (Icy Hot)?
If you think you or someone else may have overdosed on: Methyl Salicylate Topical (Icy Hot), call your doctor or the Poison Control center
(800) 222-1222
If someone collapses or isn’t breathing after taking Methyl Salicylate Topical (Icy Hot), call 911
911
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Flavor: peppermint
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Medical Disclaimer
Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place.
Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health.
Methyl salicylate – description of the substance, pharmacology, use, contraindications, formula
Contents
Structural formula
Russian name
English name
Latin name
chemical name
Gross formula
Pharmacological group of the substance Methyl salicylate
Nosological classification
CAS code
pharmachologic effect
Characteristic
Pharmacology
Application of the substance Methyl salicylate
Contraindications
Application restrictions
Side effects of the substance Methyl salicylate
Interaction
Overdose
Dosage and administration
Precautionary measures
Trade names with the active substance Methyl salicylate
Structural formula
Russian name
Methyl salicylate
English name
Methylsalicylate
Latin name
Methylii salicylas ( 9006 1 genus Methylii salicylatis)
Chemical name
Methyl ester of salicylic acid.
Generic formula
C 8 H 8 O 3
Pharmacological group of the substance Methyl salicylate
NSAIDs – Derivatives of salicylic acid
Nosological classification
ICD-10 code list
CAS code
119-36-8
Pharmacological action
Pharmacological action 9 0095-
analgesic , anti-inflammatory .
Characteristics
Colorless or yellowish liquid with a characteristic aromatic odour. Methyl salicylate is very slightly soluble in water, miscible with ethanol and ether in all proportions. Density 1.176–1.184.
Pharmacology
Non-selectively inhibits cyclooxygenase, reduces PG synthesis. Normalizes increased capillary permeability, improves microcirculation, reduces swelling and infiltration of inflamed tissues. With local application, it quickly penetrates into the deep layers of the skin, is absorbed, hydrolyzed and converted into an anion of salicylic acid.
Application of the substance Methyl salicylate
Arthritis (including rheumatic), myalgia, exudative pleurisy.
Contraindications
Hypersensitivity (including to other derivatives of salicylic acid).
Restrictions for use
Pregnancy, children.
Side effects of the substance Methyl salicylate
Irritation at the site of application, allergic skin reactions.
Interaction
Enhances the effect of anticoagulants.
Overdose
Possible in children and when applied to large areas of the skin.
Symptoms: headache, tinnitus, visual disturbances, nausea, vomiting, diarrhea, epigastric pain, respiratory alkalosis or metabolic acidosis, hyperthermia, hypokalemia, hyperglycemia.
Treatment: correction of electrolyte and water balance, forced diuresis, external body cooling; in severe cases – blood transfusion, hemodialysis.
Dosage and administration
Apply topically to the skin over the affected area of the joints and rub in lightly.
Precautions
Do not apply to broken skin. To prevent acute intoxication with salicylates, rubbing large amounts should be avoided (especially for children and pregnant women).
Trade names with active substance Methyl salicylate
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substance-liquid
Dosage
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Manufacturer
Usolye-Sibirsky KhPZ JSC
Information for healthcare professionals only.
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Methyl salicylate | it’s… What is Methyl Salicylate?
Methyl salicylate (Methylii salicylas) is a methyl ester of salicylic acid. Synonyms – Methylis salicylas, Methylium salicylicum.
In this article Methyl salicylate is considered as a drug (it is also the trade name of the drug in Russia and its INN).
Contents
|
General information
Application history
Methyl salicylate has been isolated as the main component from the oil of wintergreen and the essential oil of cherry birch. As part of these oils, the widespread medical use of methyl salicylate was begun.
General properties
A colorless volatile liquid with a strong characteristic odour, the main component of vinaigrette essential oil, currently mainly synthetic methyl salicylate is used. Applied externally as an analgesic and anti-inflammatory agent per se and mixed with chloroform, turpentine oil, fatty oils for rubbing in articular and muscular rheumatism, arthritis, exudative pleurisy.
In addition, the following finished dosage forms containing methyl salicylate are available.
- Linimentum (Balsamum) “Sanitas”].
Contains: methyl salicylate 24 g, eucalyptus oil 1.2 g, purified turpentine oil 3.2 g, camphor 5 g, lard and vaseline 33.3 g each. - Nayatox ointment
- Bom-Benge ointment (Unguentum Boum-Benge). Contains: menthol 3.9 g (or peppermint oil 7.8 g), methyl salicylate 20.2 g, medical vaseline 68.9 g, medical paraffin 7 g (per 100 g).
- Liniment “Naftalgin” (Linimentum “Naphthalginum”). Contains methyl salicylate, analgin and Naftalan oil 2.5 parts each, a mixture of fatty alcohols of sperm whale oil 3 parts, an emulsifier 13 parts, water up to 100 parts.
- Capsin (Capsinum). Liniment containing methyl salicylate 1 part, bleached oil and tincture of capsicum 2 parts each.
- Methyl salicylate liniment complex (Linimentum methylii salicylatis compositum). Contains methyl salicylate and chloroform 33.3 g each, bleached (or dope) oil 33.4 g (per 100 g).
- Salinimentum (Salinimentum). Contains: methyl salicylate and chloroform 20 g each, bleached (or dope) oil 60 g (per 100 g).


1 Application history of
Contains: methyl salicylate 24 g, eucalyptus oil 1.2 g, purified turpentine oil 3.2 g, camphor 5 g, lard and vaseline 33.3 g each.