What are the uses for trazodone 50 mg? Discover the dosage, side effects, and warnings associated with this medication. Get answers to frequently asked questions about trazodone.

Trazodone Dosage and Administration

Trazodone is typically prescribed for the treatment of major depressive disorder (MDD) in adult patients. The usual starting dose for adults is 150 mg per day, administered in divided doses. The dosage may be increased by 50 mg per day every 3-4 days, up to a maximum of 600 mg per day for inpatients or 400 mg per day for outpatients.

It’s important to note that patients should be screened for a personal or family history of bipolar disorder, mania, or hypomania before initiating trazodone treatment. Additionally, patients should be monitored for withdrawal symptoms when discontinuing the medication, and the dosage may need to be gradually reduced to avoid abrupt cessation.

Renal and Hepatic Dose Adjustments

For patients with renal or hepatic impairment, trazodone should be used with caution. The healthcare provider may need to adjust the dosage based on the patient’s individual condition and response to the medication.

Interactions and Precautions

When switching to or from a monoamine oxidase inhibitor (MAOI) used to treat psychiatric disorders, there should be a minimum of a 14-day washout period. Concomitant use of trazodone with linezolid or intravenous methylene blue should be promptly discontinued if absolutely necessary.

Healthcare providers should also consider adjusting the trazodone dose when used concurrently with strong CYP450 3A4 inducers or inhibitors, based on tolerability and therapeutic response.

Boxed Warnings and Safety Considerations

Trazodone carries a boxed warning regarding the increased risk of suicidal thoughts and behaviors in pediatric and young adult patients. The medication is not approved for use in patients younger than 18 years old, and all patients receiving trazodone should be closely monitored for clinical worsening and the emergence of suicidal thoughts or behaviors.

Additional precautions include the risk of serotonin syndrome, hyponatremia, neuroleptic malignant syndrome, and tardive dyskinesia. Patients, families, and caregivers should be educated on these potential side effects and when to seek medical attention.

Frequently Asked Questions

Does trazodone cause weight gain?

Yes, trazodone has been associated with weight gain in some patients. Healthcare providers should monitor patients for changes in weight and adjust the dosage or consider switching to an alternative medication if necessary.

Will trazodone help me sleep?

Yes, trazodone is often prescribed off-label to help treat insomnia and improve sleep quality. The sedative effects of trazodone can be beneficial for patients with difficulty falling or staying asleep.

Does Seroquel help you sleep?

Yes, the antipsychotic medication Seroquel (quetiapine) is also commonly used off-label to help treat insomnia and improve sleep. It has sedative properties that can be effective in promoting sleep.

How long does trazodone stay in your system?

Trazodone has a relatively short half-life of 3-6 hours, but its metabolites can remain in the body for a longer period. The exact duration that trazodone remains detectable may vary depending on factors such as the individual’s metabolism, dosage, and frequency of use.

How long does it take for trazodone to work?

The onset of action for trazodone can vary, but it is generally considered a relatively fast-acting antidepressant. Some patients may start to experience improvements in mood and sleep within the first week of treatment, but the full therapeutic effect may take 4-6 weeks or longer to be achieved.

Is trazodone a controlled substance?

No, trazodone is not considered a controlled substance under the Controlled Substances Act. It is classified as a non-narcotic, non-controlled medication.

Can trazodone be given to dogs?

Yes, trazodone may be prescribed off-label by veterinarians for certain conditions in dogs, such as anxiety, phobias, or sleep disorders. However, the use of trazodone in animals should always be under the supervision and guidance of a licensed veterinary professional.

Trazodone Dosage Guide + Max Dose, Adjustments

Print

Save

Medically reviewed by Drugs.com. Last updated on Jun 5, 2023.

Applies to the following strengths: 50 mg; 100 mg; 150 mg; 300 mg

Usual Adult Dose for:

• Depression

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Depression

Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days
Maximum dose:

• Inpatients: 600 mg/day
• Outpatients: 400 mg/day

Comments:

• Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment.
• Patients should be monitored for withdrawal symptoms when discontinuing therapy.
• After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response.
• If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary.
• This drug should be taken shortly after a meal or light snack.

Use: Treatment of major depressive disorder (MDD)

Renal Dose Adjustments

Use with caution.

Liver Dose Adjustments

Use with caution.

Dose Adjustments

Switching to/from a MAOI:

• From a MAOI used to treat psychiatric disorders: Allow at least 14 days before beginning this drug.
• To a MAOI used to treat psychiatric disorders: Allow at least 14 days after stopping this drug before beginning treatment with the MAOI.
• Use with linezolid or IV methylene blue: If treatment is absolutely necessary, promptly discontinue treatment with this drug.

Concomitant administration with strong CYP450 3A4 inducers/inhibitors:

• Strong CYP450 3A4 inducers: Providers should consider increasing the dose of this drug based on tolerability and therapeutic response.
• Strong CYP450 3A4 inhibitors: Providers should consider decreasing the dose of this drug based on tolerability and therapeutic response.

Treatment withdrawal:

• A gradual dose reduction is recommended instead of abrupt cessation where possible.

Precautions

US BOXED WARNINGS:
SUICIDAL THOUGHTS AND BEHAVIORS:

• Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies.
• Closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors.
• This drug is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Tablets can be swallowed whole or administered as a half tablet by breaking the tablet along the score line.
• Tablets should not be chewed or crushed.
• Tolerability may be improved by taking the drug after a meal.

Storage: Protect from light.

Reconstitution/preparation techniques:

• Oral solutions should not be mixed with other products.

Monitoring:

• Cardiovascular: Orthostatic vital signs in at-risk patients
• Metabolic: Monitor for increases in blood sugar, weight, and lipids; monitor electrolytes and fluids in patients with symptomatic hyponatremia
• Nervous system: Monitor for serotonin syndrome
• Psychiatric: Patients should be monitored for worsening and emergence of suicidal thoughts.

Patient advice:

• This drug may impair judgment, thinking, or motor skills; have patient avoid driving or operating machinery until adverse effects are determined.
• Advise patients to speak to physician or health care professional if they are pregnant, intend to become pregnant, or are breastfeeding.
• Patients should be informed of the possibility of priapism, hyponatremia, neuroleptic malignant syndrome, and tardive dyskinesia, and what to do if symptoms occur.
• Patients, families, and caregivers should be educated on the risks of suicidal thoughts and behaviors, as well as the risk of mania and hypomania; what to watch for and when to seek medical advice.

Frequently asked questions

• Does trazodone cause weight gain?
• Will trazodone help me sleep?
• Does Seroquel help you sleep?
• How long does trazodone stay in your system?
• How long does it take for trazodone to work?
• Is trazodone a controlled substance?
• Can trazodone be given to dogs?

More about trazodone

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (1,392)
• Drug images
• Latest FDA alerts (2)
• Side effects
• Patient tips
• During pregnancy
• Support group
• Drug class: phenylpiperazine antidepressants
• Breastfeeding
• En español

Patient resources

• Drug Information
• Trazodone (Advanced Reading)
• Trazodone Extended-Release Tablets
• Trazodone Tablets

Other brands

Desyrel, Oleptro, Desyrel Dividose

Professional resources

• Prescribing Information

Related treatment guides

• Anxiety
• Depression
• Fibromyalgia
• Headache

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Trazodone Interactions Checker – Drugs.com

Print

Save

There are 628 drugs known to interact with
trazodone, along with
8 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
131 are major, 482 are moderate, and 15 are minor.

Does trazodone interact with my other drugs?

Enter other medications to view a detailed report.

• View all 628 medications that may interact with trazodone
• View trazodone alcohol/food interactions (1)
• View trazodone disease interactions (8)

Most frequently checked interactions

View interaction reports for trazodone and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Abilify (aripiprazole)
• Adderall (amphetamine / dextroamphetamine)
• Ambien (zolpidem)
• Ativan (lorazepam)
• Benadryl (diphenhydramine)
• Cymbalta (duloxetine)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Klonopin (clonazepam)
• Lamictal (lamotrigine)
• Lexapro (escitalopram)
• Lipitor (atorvastatin)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Norco (acetaminophen / hydrocodone)
• Prozac (fluoxetine)
• Seroquel (quetiapine)
• Singulair (montelukast)
• Synthroid (levothyroxine)
• Topamax (topiramate)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Vyvanse (lisdexamfetamine)
• Wellbutrin (bupropion)
• Wellbutrin XL (bupropion)
• Xanax (alprazolam)
• Zoloft (sertraline)
• Zyrtec (cetirizine)

Trazodone alcohol/food interactions

There is 1 alcohol/food interaction with trazodone.

Trazodone disease interactions

There are 8 disease interactions with trazodone which include:

• angle closure glaucoma
• mania
• seizures
• suicidality
• cardiovascular disease
• hyponatremia
• hypotension
• renal/liver disease

Report options

Loading…

QR code containing a link to this page

More about trazodone

• trazodone consumer information
• Compare alternatives
• Pricing & coupons
• Reviews (1,392)
• Drug images
• Latest FDA alerts (2)
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: phenylpiperazine antidepressants
• Breastfeeding
• En español

Related treatment guides

• Anxiety
• Depression
• Fibromyalgia
• Headache

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Trazodone instructions, price in pharmacies of Ukraine

Dosage

• Trazodone: 50 mg/tablet (1)
• Trazodone: 100 mg/tablet (1)

Who can

• Older (2)
• Vagi (2)
• Inflammatory (2)
• Allergic (2)
• Diabetics (2)
• Water (2)

• Product list
• Instructions

• Prices in pharmacies

• Analogues

Product: 2

Sorting:
Behind the ratingVid cheapVid expensive

Go to box

Go to box

Analogs

Show all

Go to the box

Go to the box

Go to cat

Buy

• Vіd 243. 60 UAH

• Vіd 58.90 UAH

• Type 267.00 UAH

• Type 392.80 hryvnia

• Type 209. 00 UAH

• Type 103.30 UAH

• Type 791.20 UAH

Trazodone – psychoanaleptics. Antidepressants. Other antidepressants.

Indicated

Improvement of symptoms of all types of depression, including depression accompanied by anxiety.

Contraindications

• Hypersensitivity to the drug or to any of its components.
• Alcohol intoxication and intoxication with related diseases.
• Hostile myocardial infarction.

Side effects

Suicidal ideation and suicidal behavior have been reported during trazodone therapy . In patients with severe dyhal insufficiency, through chronic bronchial or legenous ailment, trazodone is not injected into the pCO2 or pO2 level of arterial blood.

Specific congestion

Congestion during pregnancy and breastfeeding

In connection with the lack of data on the continuation / initiation of breastfeeding or the continuation / initiation of trazodone therapy should be taken, taking into account the pain of breastfeeding for the child and the pain of trazodone therapy for the mother.

Children

Keep out of reach of children.

The ability to add to the speed of the reaction when caring for vehicles or other mechanisms

Patients should follow, that before the time, as keruvati transport means and praccyuvati s mechanisms, it is necessary to change in the presence of drowsiness, sedative effect, confusion, confusion, confusion, or vagueness of the eyes whether I am taking trazodone.

Overdose

Drowsiness, confusion, nausea and vomiting are the most common symptoms of overdose. In folded depressions, coma, tachycardia, arterial hypotension, hyponatremia, sudoma and dychal insufficiency were blamed.

Lateral symptoms may include bradycardia, low QT interval, and polymorphic tachycardia (torsade de pointes).

Symptoms may appear for 24 years after overdose or later.

One-hour overdose of trazodone and other antidepressants may cause serotonin syndrome.

Wash your safety

Save at temperatures below 25°C in the original packaging for protection from light and water, in an area inaccessible to children.

Trazodone instructions

TRAZODONE MS
(UA/18391/01/01)

Release form:

tablets of 50 mg, 10 tablets in a blister, 3 blisters in a cardboard box

Stock:

1 tablet to take: trazodone hydrochloride 50 mg

Manufacturer:

Cyprus

TRAZODONE MS
(UA/18391/01/02)

Release form:

tablets of 100 mg, 10 tablets in a blister, 3 blisters in a cardboard box

Stock:

1 tablet to take: trazodone hydrochloride 100 mg

Manufacturer:

Cyprus

Trazodone price in Pharmacy 911

Name	Price
Trazodone MS tab. 50mg №30	UAH 416.70
Trazodone MS tab. 100mg №30	525.80 UAH

Toxicological characteristics of a new drug for situational correction of behavioral abnormalities in cats and dogs Express Uspokoyin tablets

2. Dynamics of body weight gain during the 90-day use of the drug

	Body weight, g
	Control group	Experimental groups, dose of trazodone succinate, mg/kg
		340	170	68
Day 0
1	170.8	172.2	170.4	173. 2
2	175.3	173.4	175.3	170.1
3	175.1	175.5	173.7	175.6
4	173.3	173.1	173.5	171.0
5	176.6	173.8	173.3	170.3
6	175.4	172.3	174.1	173.5
7	172.8	172.1	174.3	173.9
8	172. 1	174.3	170.5	172.1
9	175.1	173.1	175.1	174.2
10	174.3	173.7	172.6	174.6
Group mean	174.08±1.78	173.35±0.05	173.28±1.69	172.85±1.88
Day 30
1	180.1	181.1	179.5	183.1
2	184.4	181.6	187. 8	183.6
3	184.3	185.2	186.2	184.3
4	183.7	184.8	183.1	180.2
5	184.0	184.0	182.6	182.9
6	186.1	183.2	183.8	184.6
7	184.5	182.5	183.3	183.1
8	183.3	186.7	180.1	184. 0
9	186.0	182.3	186.0	186.2
10	185.5	185.8	183.5	185.3
Group mean	184.19±1.71	183.72±1.87	183.59±2.59	183.73±1.62
45th day
1	182.2	182.2	182.6	184.4
2	185.5	182.4	188.7	184.8
3	185. 1	186.3	187.2	185.5
4	184.2	185.7	185.4	183.5
5	185.5	185.3	183.4	184.9
6	187.2	184.2	184.3	186.8
7	185.2	183.7	183.6	186.6
8	184.1	187.8	184.4	182.3
9	186.1	183. 2	187.6	188.4
10	186.2	186.1	184.6	189.5
Group mean	185.13± 1.36	184.69±1.32	185.18±1.44	185.67±1.57
Day 60
1	185.1	185.1	184.0	187.6
2	189.3	185.3	191.3	188.1
3	189.6	188.6	190.1	187. 4
4	187.2	188.0	186.5	185.9
5	188.8	188.7	186.1	186.0
6	189.1	187.4	187.9	187.3
7	188.0	187.2	187.5	187.1
8	189.3	190.3	185.9	188.4
9	189.4	186.0	190.0	190.7
10	189. 2	189.1	188.3	189.0
Group mean	188.50±1.40	187.57±1.70	187.76±2.24	187.75±1.41
75th day
1	187.4	186.2	186.5	189.6
2	191.5	187.5	192.4	189.1
3	191.3	190.3	192.1	190.4
4	189.7	190.4	188. 4	186.9
5	189.2	190.2	187.1	186.0
6	192.3	189.3	189.7	187.3
7	190.2	189.7	188.3	188.1
8	191.6	191.4	187.7	187.4
9	191.3	189.3	192.6	191.7
10	192.1	192.3	190.2	190. 0
Group mean	190.66±1.09	189.66±1.27	189.5±1.62	188.65±1.29
90th day
1	189.1	189.3	188.1	191.1
2	192.3	189.2	195.4	192.3
3	193.7	192.7	194.3	191.6
4	196.2	192.4	190.0	189.3
5	192. Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Comment * Name * Email * Website