What are the primary uses of vasopressin tablets. How do vasopressin tablets work in the body. What are the most common side effects of vasopressin. When should you seek medical help while taking vasopressin. How should vasopressin be administered for optimal results. What precautions should be taken when using vasopressin tablets.

Understanding Vasopressin and Its Function

Vasopressin, also known as antidiuretic hormone (ADH), plays a crucial role in regulating the body’s water balance. This hormone is naturally produced by the hypothalamus and stored in the posterior pituitary gland. When released into the bloodstream, vasopressin acts on the kidneys to control urine production and maintain proper fluid levels in the body.

In certain medical conditions, such as diabetes insipidus or following specific types of head injuries or brain surgeries, the body may not produce sufficient vasopressin. This deficiency can lead to excessive urination and increased thirst, potentially resulting in dehydration. To address this issue, synthetic vasopressin, often in the form of desmopressin, is prescribed to replace the lacking hormone and restore proper fluid balance.

How does vasopressin work in the body?

Vasopressin primarily targets the kidneys, specifically the collecting ducts. It increases water reabsorption in these structures, leading to a reduction in urine output and concentration of urine. This mechanism helps maintain the body’s water balance and prevents dehydration.

Primary Uses of Vasopressin Tablets

Vasopressin tablets, particularly in the form of desmopressin, are prescribed for various medical conditions. The primary uses include:

• Treatment of central diabetes insipidus
• Management of certain types of head injuries or post-brain surgery complications
• Control of nighttime bedwetting in children
• Treatment of certain bleeding disorders

Can vasopressin tablets help with diabetes insipidus?

Yes, vasopressin tablets are highly effective in treating central diabetes insipidus. This condition occurs when the body doesn’t produce enough vasopressin, leading to excessive urine production and increased thirst. By replacing the missing hormone, desmopressin helps regulate urine output and alleviates symptoms associated with diabetes insipidus.

Proper Administration of Vasopressin Tablets

The correct administration of vasopressin tablets is crucial for their effectiveness and safety. Here are some key points to consider:

1. Dosage frequency: For diabetes insipidus, the medication is typically taken 2 to 3 times daily, as prescribed by a healthcare provider.
2. Bedwetting treatment: When used for nighttime bedwetting in children, it’s usually administered once daily at bedtime.
3. Fluid intake: Patients, especially children and older adults, must carefully monitor and limit their fluid intake as directed by their doctor.
4. Consistency: Take the medication at the same time(s) each day to maintain its effectiveness.
5. Follow-up: Regular check-ups and lab tests are essential to monitor the medication’s efficacy and adjust the dosage if needed.

Why is it important to limit fluid intake when taking vasopressin tablets?

Limiting fluid intake while using vasopressin tablets is crucial to prevent a potentially dangerous condition called hyponatremia, or low sodium levels in the blood. Vasopressin causes the body to retain water, and excessive fluid intake can dilute the sodium concentration in the blood, leading to serious health complications. Therefore, following the doctor’s guidelines on fluid restriction is essential for safe and effective treatment.

Common Side Effects of Vasopressin Tablets

While vasopressin tablets are generally well-tolerated, some patients may experience side effects. The most common side effects include:

• Headache
• Nausea
• Upset stomach
• Flushing of the face

These side effects are usually mild and often resolve on their own. However, if they persist or worsen, it’s important to consult with a healthcare provider.

Are there any serious side effects associated with vasopressin tablets?

While rare, serious side effects can occur with vasopressin tablets. The most significant concern is hyponatremia, or low sodium levels in the blood. Symptoms of hyponatremia may include:

• Severe headache
• Nausea and vomiting
• Muscle weakness or cramps
• Unusual tiredness or drowsiness
• Dizziness
• Confusion or irritability
• Seizures (in severe cases)

If any of these symptoms occur, it’s crucial to seek immediate medical attention. Additionally, although rare, some patients may experience a severe allergic reaction to the medication, characterized by rash, itching, swelling, severe dizziness, or difficulty breathing. Such reactions require emergency medical care.

Precautions and Warnings for Vasopressin Use

Before starting treatment with vasopressin tablets, it’s essential to be aware of certain precautions and warnings:

1. Medical history: Inform your doctor about any pre-existing medical conditions, especially those affecting kidney function, heart problems, or a history of low sodium levels.
2. Age considerations: Older adults (65 years and above) may be at higher risk of developing hyponatremia and should be monitored closely.
3. Medication interactions: Certain medications, such as diuretics or glucocorticoids, may increase the risk of hyponatremia when used with vasopressin.
4. Fluid intake: Strictly adhere to the fluid intake guidelines provided by your healthcare provider.
5. Regular monitoring: Attend all scheduled medical appointments and lab tests to ensure the medication is working effectively and safely.
6. Pregnancy and breastfeeding: Discuss the potential risks and benefits with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Who should not take vasopressin tablets?

Vasopressin tablets may not be suitable for everyone. Individuals with the following conditions should exercise caution or avoid using this medication:

• History of allergic reactions to desmopressin or similar medications
• Severe kidney disease
• Uncontrolled hypertension
• Heart failure
• Conditions that may cause fluid or electrolyte imbalance
• Type 1b von Willebrand disease (when used for bleeding disorders)

Always consult with a healthcare provider to determine if vasopressin tablets are appropriate for your specific medical condition.

Monitoring and Follow-up During Vasopressin Treatment

Proper monitoring and regular follow-ups are essential components of successful vasopressin treatment. Here’s what patients can expect:

1. Initial assessment: Before starting treatment, your doctor will conduct a thorough evaluation, including blood tests to check sodium levels and kidney function.
2. Dose adjustment: The initial dosage may be adjusted based on your response to the medication and any side effects experienced.
3. Regular blood tests: Periodic blood tests will be conducted to monitor sodium levels and ensure they remain within a safe range.
4. Urine tests: These may be performed to assess the medication’s effectiveness in controlling urine output.
5. Clinical evaluations: Regular check-ups allow your healthcare provider to assess your overall response to the treatment and address any concerns.
6. Long-term monitoring: For patients on long-term vasopressin therapy, ongoing monitoring is crucial to ensure continued safety and efficacy.

How often should patients on vasopressin tablets have their sodium levels checked?

The frequency of sodium level checks can vary depending on individual factors such as age, overall health, and response to treatment. Initially, tests may be conducted more frequently, possibly weekly or bi-weekly. As treatment stabilizes, the interval between tests may be extended. However, most patients on long-term vasopressin therapy should have their sodium levels checked at least every 3-6 months, or more frequently if advised by their healthcare provider.

Lifestyle Considerations While Taking Vasopressin Tablets

While vasopressin tablets can effectively manage conditions like diabetes insipidus or bedwetting, certain lifestyle adjustments may be necessary to ensure optimal treatment outcomes and minimize risks:

• Fluid management: Carefully monitor and limit fluid intake as directed by your healthcare provider. This is particularly important in the evening for those taking the medication for bedwetting.
• Dietary considerations: Be mindful of foods with high water content, as these can contribute to your overall fluid intake.
• Alcohol consumption: Limit or avoid alcohol, as it can interfere with the body’s water balance and the effectiveness of vasopressin.
• Physical activity: Inform your doctor about your exercise routine, as intense physical activity may affect fluid balance and require dosage adjustments.
• Travel preparations: If traveling, especially to hot climates, consult your doctor about any necessary precautions or dosage modifications.
• Stress management: Chronic stress can impact hormone levels, including vasopressin. Incorporate stress-reduction techniques into your daily routine.

How can patients effectively manage their fluid intake while on vasopressin tablets?

Managing fluid intake while on vasopressin tablets requires careful planning and awareness. Here are some practical tips:

1. Use a measured water bottle to track daily fluid consumption
2. Spread fluid intake evenly throughout the day, avoiding large quantities at once
3. Be mindful of hidden fluids in foods like soups, fruits, and ice cream
4. Limit fluid intake in the evening, especially for those treating bedwetting
5. Keep a fluid intake diary to share with your healthcare provider during check-ups
6. Use sugar-free hard candies or ice chips to alleviate dry mouth without consuming excess fluids

Remember, the specific fluid intake recommendations will vary based on individual factors and should be determined in consultation with your healthcare provider.

Long-term Outlook and Management of Vasopressin Treatment

For many patients, vasopressin treatment is a long-term or even lifelong therapy. Understanding the long-term outlook and management strategies is crucial for maintaining health and quality of life:

• Efficacy over time: Most patients experience consistent benefits from vasopressin tablets when taken as prescribed. However, the body’s response may change over time, necessitating dosage adjustments.
• Regular evaluations: Periodic assessments of treatment efficacy and potential side effects are essential, even for long-term users.
• Adaptation strategies: Patients often develop personal strategies for managing their condition and medication regimen over time. Sharing these insights with healthcare providers can be valuable.
• Technological aids: Consider using smartphone apps or other tools to help track medication schedules, fluid intake, and symptoms.
• Support systems: Engaging with support groups or online communities can provide valuable insights and emotional support for long-term management.
• Lifestyle integration: Work with your healthcare team to integrate vasopressin treatment seamlessly into your lifestyle, accommodating work, social activities, and personal preferences.

Can patients develop tolerance to vasopressin tablets over time?

While true tolerance to vasopressin tablets is rare, some patients may experience changes in their response to the medication over time. This could be due to various factors, including:

1. Changes in the underlying condition
2. Age-related physiological changes
3. Development of other medical conditions
4. Interactions with new medications

If you notice a decrease in the medication’s effectiveness, it’s important to consult your healthcare provider. They may adjust the dosage or explore alternative treatment options to ensure continued symptom management.

Alternatives and Complementary Approaches to Vasopressin Treatment

While vasopressin tablets are highly effective for many patients, some individuals may benefit from alternative or complementary approaches:

• Alternative medications: For certain conditions, such as bedwetting, other medications like anticholinergics or tricyclic antidepressants might be considered.
• Behavioral interventions: Especially for bedwetting, techniques like bladder training or motivational therapy can be effective, either alone or in combination with medication.
• Dietary modifications: In some cases, adjusting salt intake or overall diet composition may help manage symptoms, particularly for diabetes insipidus.
• Herbal remedies: Some patients explore herbal options, though these should always be discussed with a healthcare provider due to potential interactions.
• Acupuncture: This traditional Chinese medicine technique has shown promise in managing some urinary disorders, though more research is needed.
• Pelvic floor exercises: For certain urinary issues, strengthening the pelvic floor muscles may provide benefits.

Are there any natural alternatives to vasopressin tablets?

While natural alternatives cannot fully replace vasopressin tablets for conditions like diabetes insipidus, some complementary approaches may help manage symptoms:

1. Herbs like uva ursi or cornsilk, which have traditional uses in urinary health (consult a healthcare provider before use)
2. Dietary changes, such as reducing caffeine and alcohol intake, which can affect fluid balance
3. Stress reduction techniques like meditation or yoga, as stress can influence hormone levels
4. Adequate sleep and regular exercise to support overall hormonal balance

It’s crucial to note that these approaches should not replace prescribed vasopressin treatment without medical supervision. Always consult with your healthcare provider before incorporating any alternative therapies into your treatment plan.

DDAVP Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Desmopressin can rarely cause a low level of sodium in the blood (hyponatremia), which can be serious or even fatal. Drinking too much liquid, using certain medications (such as “water pills”/diuretics including furosemide, glucocorticoids such as prednisone), being 65 years or older, or having certain medical conditions may increase the risk of low sodium in the blood. Lab tests (such as urine tests, sodium blood levels) must be done before you start using this medication and while you are using it. Keep all medical and lab appointments.

Tell your doctor right away if you develop symptoms of low sodium in the blood, such as nausea, vomiting, headache, muscle weakness/cramps, unusual tiredness, unusual drowsiness, dizziness, restlessness, mental/mood changes including confusion/irritability.

Get medical help right away if you have any very serious side effects, including seizure or trouble breathing.

Warnings:

Desmopressin can rarely cause a low level of sodium in the blood (hyponatremia), which can be serious or even fatal. Drinking too much liquid, using certain medications (such as “water pills”/diuretics including furosemide, glucocorticoids such as prednisone), being 65 years or older, or having certain medical conditions may increase the risk of low sodium in the blood. Lab tests (such as urine tests, sodium blood levels) must be done before you start using this medication and while you are using it. Keep all medical and lab appointments.

Tell your doctor right away if you develop symptoms of low sodium in the blood, such as nausea, vomiting, headache, muscle weakness/cramps, unusual tiredness, unusual drowsiness, dizziness, restlessness, mental/mood changes including confusion/irritability.

Get medical help right away if you have any very serious side effects, including seizure or trouble breathing.

… Show More

Uses

Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have “water diabetes” (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration.Desmopressin is also used to control nighttime bedwetting in children. It reduces how often your child urinates and decreases the number of bedwetting episodes.

How to use DDAVP

For the treatment of diabetes insipidus, take this medication by mouth, usually 2 to 3 times a day or as directed by your doctor.

For the treatment of bedwetting, take this medication by mouth, usually once a day at bedtime. Children should limit the fluids they drink after dinner, especially 1 hour before the desmopressin dose until the next morning, or at least 8 hours after the dose. If your child wakes up during the night, limit the amount that your child drinks.

All patients taking desmopressin, especially children and older adults, must limit drinking of water and other fluids. Consult your doctor for details. If you find that you are drinking more fluids than directed, tell your doctor right away. Your treatment will need to be adjusted.

Dosage is based on your medical condition and response to treatment. Do not take more desmopressin or take it more often than prescribed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition does not improve or if this medication stops working well.

Side Effects

See also Warning section.

Headache, nausea, upset stomach, or flushing of the face may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, high blood pressure, heart problems (such as blocked blood vessels, heart failure), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis), the urge to drink too much water without being thirsty, a low level of sodium in the blood (hyponatremia), bleeding/clotting problems.

If you become dehydrated, your doctor will correct that condition first before starting treatment with desmopressin.

Limit alcohol because it can interfere with how well desmopressin works.

Tell the doctor right away if you develop any illness that can cause water/mineral imbalance (including fever, diarrhea, vomiting, infections such as the flu) or if you experience conditions that require drinking more fluids (for example, exposure to very hot weather, strenuous exercise, heavy sweating). The doctor may need to stop or adjust desmopressin treatment, especially in children and older adults.

Children may be more sensitive to the side effects of this drug, especially water/mineral imbalance and a low level of sodium in the blood.

Older adults may be at greater risk for water/mineral imbalance and a low level of sodium in the blood while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: tolvaptan, “water pills”/diuretics (such as furosemide).

Does DDAVP interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: headache that is severe or doesn’t go away, confusion, drowsiness, sudden weight gain.

Do not share this medication with others.

Lab and/or medical tests (such as urine tests, sodium blood level) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you take 1 dose daily and miss a dose, take it as soon as you remember. If you do not remember until the next day, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

If you take more than 1 dose daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

DDAVP 0.2 mg tablet

Color: whiteShape: roundImprint: 0.2

This medicine is a white, round, scored, tablet imprinted with “0.2”.

DDAVP 0.1 mg tablet

Color: whiteShape: ovalImprint: 0.1

This medicine is a white, round, scored, tablet imprinted with “0.2”.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Diabetes insipidus – Treatment – NHS

Treatments for diabetes insipidus aim to reduce the amount of urine your body produces.

Depending on the type of diabetes insipidus you have, there are several ways of treating your condition and controlling your symptoms.

Cranial diabetes insipidus

Mild cranial diabetes insipidus may not require any medical treatment.

Cranial diabetes insipidus is considered mild if you produce approximately 3 to 4 litres of urine over 24 hours.

If this is the case, you may be able to ease your symptoms by increasing the amount of water you drink to avoid dehydration.

Your GP or endocrinologist (a specialist in hormone conditions) may advise you to drink a certain amount of water every day, usually at least 2.5 litres.

But if you have more severe cranial diabetes insipidus, drinking water may not be enough to control your symptoms.

As your condition is caused by a shortage of vasopressin (AVP), your GP or endocrinologist may prescribe a treatment that takes the place of AVP, known as desmopressin.

Desmopressin

Desmopressin is a manufactured version of AVP that’s more powerful and more resistant to being broken down than the AVP naturally produced by your body.

It works just like natural AVP, stopping your kidneys producing urine when the level of water in your body is low.

Desmopressin can be taken as a nasal spray, in tablet form or as a form that melts in your mouth, between your gum and your lip.

If you’re prescribed desmopressin as a nasal spray, you’ll need to spray it inside your nose once or twice a day, where it’s quickly absorbed into your bloodstream.

If you’re prescribed desmopressin tablets, you may need to take them more than twice a day.

This is because desmopressin is absorbed into your blood less effectively through your stomach than through your nasal passages, so you need to take more to have the same effect.

Your GP or endocrinologist may suggest switching your treatment to tablets if you develop a cold that prevents you using the nasal spray.

Desmopressin is very safe to use and has few side effects.

But possible side effects can include:

• headache
• stomach pain
• feeling sick
• a blocked or runny nose
• nosebleeds

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water.

This can result in:

• headaches
• dizziness
• feeling bloated
• hyponatraemia – a low level of sodium (salt) in your blood

Symptoms of hyponatraemia include:

• a severe or prolonged headache
• confusion
• feeling sick (nausea) and vomiting

If you think you may have hyponatraemia, stop taking desmopressin immediately and call your GP for advice.

If this is not possible, go to your local A&E department.

Nephrogenic diabetes insipidus

If you have nephrogenic diabetes insipidus that’s caused by taking a particular medication, such as lithium or tetracycline, your GP or endocrinologist may stop your treatment and suggest an alternative medication.

But do not stop taking it unless you have been advised to by a healthcare professional.

As nephrogenic diabetes insipidus is caused by your kidneys not responding to AVP, rather than a shortage of AVP, it usually cannot be treated with desmopressin.

But it’s still important to drink plenty of water to avoid dehydration.

If your condition is mild, your GP or endocrinologist may suggest reducing the amount of salt and protein in your diet, which will help your kidneys produce less urine.

This may mean eating less salt and protein-rich food, such as processed foods, meat, eggs and nuts.

Do not alter your diet without first seeking medical advice.

Your GP or endocrinologist will be able to advise you about which foods to cut down on.

Find out more about eating a healthy, balanced diet.

If you have more severe nephrogenic diabetes insipidus, you may be prescribed a combination of thiazide diuretics and a non-steroidal anti-inflammatory drug (NSAID) to help reduce the amount of urine your kidneys produce. 

Thiazide diuretics

Thiazide diuretics can reduce the rate the kidneys filter blood, which reduces the amount of urine passed from the body over time.

Side effects are uncommon, but include:

• dizziness when standing
• indigestion
• very sensitive skin
• erectile dysfunction (impotence) in men 

This last side effect is usually temporary and should resolve itself if you stop taking the medication.

Non-steroidal anti-inflammatory drugs (NSAIDs)

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, help reduce urine volume further when they’re used in combination with thiazide diuretics.

But long-term use of NSAIDs increases your risk of developing a stomach ulcer.

To counter this increased risk, an additional medication called a proton pump inhibitor (PPI) may be prescribed.

PPIs help protect your stomach lining against the harmful effects of NSAIDs, reducing the risk of ulcers forming.

Find out more about treating stomach ulcers

Help with health costs

If you have diabetes insipidus, you do not have to pay prescription charges for desmopressin.

You’ll need to fill in a medical exemption (MedEx) certificate to qualify.

See who can get free prescriptions for more information about how to apply for a MedEx certificate.

You may have to pay for other medicines that may be required on a short-term basis, such as thiazide diuretics.

Support

Read more about diabetes insipidus and how to get support from the Pituitary Foundation

Page last reviewed: 13 October 2022
Next review due: 13 October 2025

H. Systemic hormonal preparations other than sex hormones and insulins \ ConsultantPlus

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Fidelity Pills – KP.

RU

Komsomolskaya Pravda

Search results :00

Scientists are encouraging: a substance has been found that can be used to create a drug against adultery

As it turned out, as many as two issues of the “Man and Woman” column, which were devoted to scientific searches for the causes of going to the left and ways to stop them, did not cover the whole variety of topics (“Is there a cure for infidelity?”, “Coercion to fidelity”, see “KP” of September 6 and 13, 2008). Recently, new discoveries have arrived. And they testify: not only instincts and psychology are involved in adultery. But also chemistry. A substance has been discovered that averts fornication and generates a sense of fidelity to a single partner. Thanks to him, according to scientists, next to us there are people who can not change.

Cheating genes

The search for the chemical causes of infidelity began about seven years ago. And, as usual, from experiments on mice. Fortunately, among these animals there are two amazing populations – meadow voles and steppe voles. The males of the first are extremely lascivious, mating right and left. And those from the second, all their mouse life remain faithful to one female. Scientists decided to figure out why such a miracle happens. And they seem to have figured it out.

“Our study, in a relatively simple biological model, provides evidence that boosting the activity of just one gene profoundly changes the foundations of social behavior,” said Larry Young, a professor at Emory University in Georgia.

It turned out that the heads of faithful and unfaithful mice contain a different number of receptors that perceive the hormone vasopressin. It is produced by the brain in one area, and absorbed in another. This hormone, scientists have suggested, and generates a sense of attachment. Moreover, it creates a very pleasant feeling that one female is enough to satisfy sexual needs. The bold hypothesis was also reinforced by the fact that the faithful mice showed an excess of both the hormone itself and the receptors that perceive it.

To test, American neuroscientists transferred the gene responsible for vasopressin receptors from monogamous steppe voles to meadow lovers to go left. And a fantastic transformation happened: the Casanova mice became faithful “husbands” without exception. This is the magical power of chemistry.

People are like mice

Impressive results were obtained back in 2004. But since they belonged to “simple biological models”, they did not create confidence that they could be transferred to more complex ones – to people. Doubts were dispelled by recent research conducted at the Swedish Karolinska Institute under the direction of Professor Hass Walum. Scientists have discovered a striking similarity between people and their smaller brothers in terms of the chemical nature of adultery. It turned out that the human brain interacts with vasopressin in exactly the same way as the mouse. Faithful men found more of the hormone, and it was absorbed better. For cheaters, the opposite is true. And the reason is the same – the genetic difference of one from the other.

Conclusions: vasopressin has a serious claim to be the human hormone of fidelity. This is first. Secondly, not all men are cheaters. There is a breed of people in whom nature has beaten off the inclination to fornication, while retaining both the libido and the ability to receive sincere satisfaction from sexual intercourse with a single partner. Such, according to opinion polls, from a quarter to a third of the stronger sex.

Alas, it is still a mystery whether there is a genetic difference between women of easy sexual behavior and those who profess marital fidelity.

Prescribe me, doctor…

Vasopressin is a known hormone. News – its role in human relationships and in influencing social behavior. Naturally, the question arises: is it possible, on the basis of this hormone, to create a drug for the “treatment” of infidelity? Theoretically – yes, scientists answer. But more research is needed. After all, it is stupid to drink vasopressin or inject it dangerously. Like any hormone. Yes, and there are side effects – the most famous, for example, difficult urination (analogs of vasopressin are prescribed for patients with enuresis). Would a healthy husband in this sense want to make such a sacrifice? However, medical science does not stand still. Scientists will come up with something – synthetically harmless. And make humanity happy with fidelity pills.

Vladimir LAGOVSKY

SPECIALIST’S OPINION

Dilute with tenderness!

Natalya GRIDASOVA, psychoendocrinologist, doctor of the highest category:

– Vasopressin belongs to a group of hormones that are produced by a very important part of the brain – the pituitary gland, and is responsible for regulating the amount of fluids in the body. And disinhibited sexual behavior (simply – pathological infidelity) is often distinguished by people who have just the same function of the pituitary gland.

Of course, one cannot say directly, they say, inject your “walker” with vasopressin, and he will sit beside you like silk. But perhaps there is a rational grain in these studies. And the medicine “for infidelity” will act just on those men who run to the left not because of natural depravity or because the partner does not suit, but “due to illness.”

Vasopressin also affects the secretion of oxytocin, the hormone of tenderness, which is responsible for the emotional component of sexual relations and enhances attachment to a partner.

In large doses, vasopressin greatly increases pressure in tissues, including the brain, and this can be very dangerous for health.

Elena IONOVA.

BTW

Sleep well

Endocrinologists at the Faculty of Medicine of the University of Lübeck, led by Jan Born, discovered that inhaling an aerosol preparation containing vasopressin in the morning and evening has a hypnotic effect. But it also weakens memory.

In principle, an attractive combination of side effects: a faithful husband sleeps well, pees little and does not remember insults.

Maybe scientists are trying in vain? There is little demand for chastity pills. Slightly higher than on a baldness balm. It is strange, however… Although there are suspicions that in our sociological survey mainly traitors participated, for whom some kind of “non-leftist” is a threat to a lustful lifestyle. Like bromine for Casanova. Or do people really cope with adultery non-drug? Through love and willpower? And rely on natural feelings? Showing no interest even in a love potion?

Another interpretation is not ruled out. Logically sound. After all, if you restore a peppy and fresh look, become smart and slender teetotalers, then other problems – partner’s infidelity, baldness and insufficient attention of the opposite sex – will seem secondary and easily solved. This is what Faust thought when he sold his soul. Looks like we haven’t changed much since then?

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