Vilazodone interactions. Vilazodone (Viibryd): Comprehensive Guide to Uses, Interactions, and Side Effects

10.03.202316.07.2023 by alexxlab

What is vilazodone used to treat. How does vilazodone work in the brain. What are the potential side effects of vilazodone. How should vilazodone be taken for optimal results. What precautions should be considered when using vilazodone.

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Understanding Vilazodone: An Antidepressant for Major Depressive Disorder

Vilazodone, marketed under the brand name Viibryd, is an antidepressant medication primarily used in the treatment of major depressive disorder (MDD). This FDA-approved drug works by affecting certain chemicals in the brain, specifically serotonin, which plays a crucial role in mood regulation.

What is Major Depressive Disorder?

Major depressive disorder is a serious mental health condition characterized by persistent feelings of sadness, hopelessness, and loss of interest in daily activities. Symptoms of MDD can significantly impact a person’s quality of life and may include:

Depressed mood – feeling sad, empty, or tearful
Feelings of worthlessness, guilt, hopelessness, and helplessness
Loss of interest or pleasure in usual activities
Changes in sleep and eating patterns
Low energy and difficulty concentrating
Thoughts of death or suicidal ideation
Psychomotor agitation or retardation

How effective is vilazodone in treating major depressive disorder? Clinical studies have shown that vilazodone can significantly reduce symptoms of depression in many patients, with improvements often noticeable within a few weeks of starting treatment.

Mechanism of Action: How Vilazodone Works in the Brain

Vilazodone belongs to a class of medications known as serotonin modulators and stimulators. Its unique mechanism of action involves two primary effects on the brain:

Selective serotonin reuptake inhibition (SSRI): Vilazodone blocks the reabsorption of serotonin in the brain, increasing its availability.
Partial agonism of 5-HT1A receptors: The drug partially activates specific serotonin receptors, modulating serotonin activity.

This dual action is believed to contribute to vilazodone’s antidepressant effects, potentially offering benefits over traditional SSRIs for some patients.

The Role of Serotonin in Depression

Why is serotonin important in treating depression? Serotonin is a neurotransmitter that plays a crucial role in regulating mood, emotions, and various cognitive functions. In individuals with depression, serotonin levels or activity may be disrupted. By modulating serotonin, vilazodone aims to restore balance and alleviate depressive symptoms.

Dosage and Administration: Optimal Use of Vilazodone

Proper administration of vilazodone is crucial for its effectiveness and minimizing potential side effects. The medication is available in tablet form, with strengths of 10 mg, 20 mg, and 40 mg.

Recommended Dosing Schedule

How should vilazodone be taken for optimal results? Vilazodone is typically administered once daily with food. The usual starting dose is 10 mg per day, which is gradually increased over several weeks to reach the target dose of 20-40 mg per day. This gradual titration helps minimize side effects and allows the body to adjust to the medication.

It’s essential to take vilazodone consistently and not to abruptly stop or change the dosage without consulting a healthcare provider. Sudden discontinuation can lead to withdrawal symptoms and potentially worsen depression.

Side Effects and Precautions: What to Watch For

Like all medications, vilazodone can cause side effects. While not everyone experiences adverse reactions, it’s important to be aware of potential issues that may arise during treatment.

Common Side Effects

What are the most frequently reported side effects of vilazodone? Common side effects may include:

Diarrhea
Nausea
Vomiting
Insomnia or unusual dreams
Dizziness
Sexual dysfunction
Dry mouth

These side effects are often mild and may diminish over time as the body adjusts to the medication. However, if they persist or become bothersome, it’s important to consult with a healthcare provider.

Serious Side Effects and Precautions

While rare, some serious side effects may occur with vilazodone use. These can include:

Serotonin syndrome
Increased risk of suicidal thoughts or behaviors, especially in young adults
Manic episodes in individuals with bipolar disorder
Bleeding problems, especially when combined with certain medications
Low sodium levels (hyponatremia)

What signs should prompt immediate medical attention when taking vilazodone? Symptoms such as severe agitation, hallucinations, rapid heartbeat, severe dizziness, or severe nausea, vomiting, or diarrhea should be reported to a healthcare provider immediately.

Drug Interactions: Medications to Avoid with Vilazodone

Vilazodone can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform healthcare providers about all medications, supplements, and herbal products being used.

Key Drug Interactions

What medications should be avoided when taking vilazodone? Some important interactions to be aware of include:

Monoamine oxidase inhibitors (MAOIs)
Other serotonergic drugs (e.g., other antidepressants, triptans)
NSAIDs or aspirin
Warfarin and other blood thinners
Certain antipsychotics and mood stabilizers

Additionally, alcohol should be avoided or used with caution while taking vilazodone, as it can increase the risk of side effects and potentially worsen depression symptoms.

Vilazodone and Pregnancy: Important Considerations

The use of vilazodone during pregnancy requires careful consideration of the potential risks and benefits. While research on vilazodone’s effects during pregnancy is limited, untreated depression also poses risks to both the mother and developing fetus.

Pregnancy and Breastfeeding

Is vilazodone safe to use during pregnancy and breastfeeding? The current evidence suggests that vilazodone may be used during pregnancy if the potential benefits outweigh the risks. However, each case should be evaluated individually by a healthcare provider.

Vilazodone does pass into breast milk, so caution is advised for breastfeeding mothers. The decision to use vilazodone while breastfeeding should be made in consultation with a healthcare provider, considering the importance of the medication for the mother and potential effects on the infant.

Managing Vilazodone Treatment: Tips for Success

Successful treatment with vilazodone involves more than just taking the medication as prescribed. Here are some tips to help maximize the benefits of vilazodone treatment:

Adherence and Monitoring

Take vilazodone consistently at the same time each day with food
Use reminders or pill organizers to avoid missed doses
Keep regular appointments with your healthcare provider for monitoring
Report any new or worsening symptoms promptly
Be patient, as it may take several weeks to experience the full benefits of the medication

Lifestyle Considerations

How can lifestyle changes support vilazodone treatment? Incorporating healthy habits can enhance the effectiveness of vilazodone and promote overall mental well-being:

Engage in regular physical exercise
Maintain a balanced diet and stay hydrated
Practice good sleep hygiene
Consider complementary therapies like cognitive-behavioral therapy
Build a strong support network of friends and family

Long-term Use and Discontinuation of Vilazodone

For many individuals with major depressive disorder, long-term treatment with vilazodone may be necessary to maintain symptom relief and prevent relapse. However, the duration of treatment should be determined on an individual basis in consultation with a healthcare provider.

Discontinuation Considerations

What happens when it’s time to stop taking vilazodone? Discontinuation of vilazodone should always be done gradually under medical supervision. Abrupt cessation can lead to discontinuation syndrome, characterized by symptoms such as:

Irritability
Nausea and vomiting
Dizziness
Headaches
Paresthesias (tingling or prickling sensations)
Anxiety or agitation

A tapering schedule, where the dose is gradually reduced over time, can help minimize these effects and ensure a smooth transition off the medication.

Long-term Monitoring

How should patients be monitored during long-term vilazodone treatment? Regular follow-ups with a healthcare provider are essential to assess ongoing effectiveness, monitor for side effects, and make any necessary adjustments to the treatment plan. This may include periodic blood tests to check for potential metabolic changes or other health impacts.

Vilazodone vs. Other Antidepressants: Comparative Efficacy

While vilazodone has shown effectiveness in treating major depressive disorder, it’s natural to wonder how it compares to other antidepressant medications. Understanding these comparisons can help patients and healthcare providers make informed decisions about treatment options.

Vilazodone vs. SSRIs

How does vilazodone compare to traditional SSRIs like fluoxetine or sertraline? While vilazodone shares some similarities with SSRIs, its additional action on 5-HT1A receptors may offer potential advantages:

Potentially faster onset of action
Possibly reduced sexual side effects compared to some SSRIs
Potentially beneficial effects on anxiety symptoms associated with depression

However, direct head-to-head studies comparing vilazodone to other antidepressants are limited, and individual responses can vary significantly.

Unique Features of Vilazodone

What sets vilazodone apart from other antidepressants? Some unique aspects of vilazodone include:

Dual mechanism of action (SSRI + partial 5-HT1A agonist)
Potentially lower risk of weight gain compared to some other antidepressants
May have a more favorable sexual side effect profile for some patients

It’s important to note that the choice of antidepressant should be individualized based on a patient’s specific symptoms, medical history, and potential side effect profile.

Future Directions: Ongoing Research and Potential Applications

As with many psychiatric medications, research into vilazodone continues to explore its potential applications and long-term effects. Understanding these areas of investigation can provide insight into the future of depression treatment.

Expanding Indications

What other conditions might vilazodone potentially treat? While currently approved only for major depressive disorder, researchers are investigating vilazodone’s potential efficacy in other psychiatric conditions, including:

Generalized anxiety disorder
Social anxiety disorder
Post-traumatic stress disorder (PTSD)
Premenstrual dysphoric disorder (PMDD)

These studies aim to determine if vilazodone’s unique mechanism of action could provide benefits in treating a broader range of mood and anxiety disorders.

Long-term Efficacy and Safety

How does vilazodone perform in long-term use? Ongoing studies are examining the long-term efficacy and safety profile of vilazodone, focusing on:

Maintenance of antidepressant effects over extended periods
Long-term impact on cognitive function and quality of life
Potential metabolic effects with prolonged use
Comparison of long-term outcomes with other antidepressant classes

These studies will provide valuable information to guide clinical decision-making and optimize long-term management of depression with vilazodone.

Patient Experiences: Real-World Insights on Vilazodone Use

While clinical trials provide essential data on vilazodone’s efficacy and safety, real-world patient experiences offer valuable insights into the day-to-day realities of using this medication. Understanding these perspectives can help set realistic expectations and improve patient education.

Common Patient Observations

What do patients typically report about their experiences with vilazodone? Some common themes from patient feedback include:

Initial side effects, particularly gastrointestinal issues, that often improve over time
Gradual improvement in mood and energy levels over several weeks
Variations in sexual side effects, with some reporting improvements compared to previous antidepressants
The importance of taking the medication with food to minimize side effects
Individual variations in response and side effect profiles

It’s important to note that individual experiences can vary widely, and what works well for one person may not be as effective for another.

Strategies for Success

How can patients maximize their chances of success with vilazodone? Based on real-world experiences, some helpful strategies include:

Being patient during the initial weeks as the body adjusts to the medication
Maintaining open communication with healthcare providers about side effects and concerns
Combining medication with therapy or counseling for a comprehensive treatment approach
Developing a consistent routine for taking the medication with food
Engaging in self-care practices to support overall mental health

These insights from patient experiences can help individuals starting vilazodone treatment feel more prepared and empowered in their journey towards managing depression.

Vilazodone (Viibryd) | NAMI: National Alliance on Mental Illness

Generic name: vilazodone (vil AZ oh done)

Brand name: Viibryd®

Tablets: 10 mg, 20 mg, 40 mg

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What Is Vilazodone And What Does It Treat?

Vilazodone is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD).

Symptoms of depression include:

Depressed mood – feeling sad, empty, or tearful

Feeling worthless, guilty, hopeless, and helpless

Loss of interest or pleasure in your usual activities

Sleep and eat more or less than usual (for most people it is less)

Low energy, trouble concentrating, or thoughts of death (suicidal thinking)

Psychomotor agitation (‘nervous energy’)

Psychomotor retardation (feeling like you are moving and thinking in slow motion)

Suicidal thoughts or behaviors

What Is The Most Important Information I Should Know About Vilazodone?

Do not stop taking vilazodone, even when you feel better. With input from you, your health care provider will assess how long you will need to take the medicine.

Missing doses of vilazodone may increase your risk for relapse in your symptoms.

Stopping vilazodone abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Depression is also a part of bipolar illness. People with bipolar disorder who take antidepressants may be at risk for “switching” from depression into mania. Symptoms of mania include “high” or irritable mood, very high self-esteem, decreased need for sleep, pressure to keep talking, racing thoughts, being easily distracted, frequently involved in activities with a large risk for bad consequences (for example, excessive buying sprees).

Medical attention should be sought if serotonin syndrome is suspected. Please refer to serious side effects for signs/symptoms.

Are There Specific Concerns About Vilazodone And Pregnancy?

If you are planning on becoming pregnant, notify your health care provider to best manage your medications. People living with MDD who wish to become pregnant face important decisions. Untreated MDD has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Caution is advised with breastfeeding since vilazodone does pass into breast milk.

What Should I Discuss With My Health Care Provider Before Taking Vilazodone?

Symptoms of your condition that bother you the most

If you have thoughts of suicide or harming yourself

Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects

If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication.

Any other psychiatric or medical problems you have, including a history of bipolar disorder

All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have

Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication.

If you are pregnant, plan to become pregnant, or are breastfeeding

If you drink alcohol or use drugs

How Should I Take Vilazodone?

Vilazodone is usually taken one time per day with food or milk.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The dose usually ranges from 20 mg to 40 mg. Only your health care provider can determine the correct dose for you.

Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or friend to remind you or check in with you to be sure you are taking your medication.

What Happens If I Miss A Dose Of Vilazodone?

If you miss a dose of vilazodone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.

What Should I Avoid While Taking Vilazodone?

Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may decrease the benefits (e.g., worsen your condition) and increase adverse effects (e.g., sedation) of the medication.

What Happens If I Overdose With Vilazodone?

If an overdose occurs, call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

A specific treatment to reverse the effects of vilazodone does not exist.

What Are The Possible Side Effects Of Vilazodone?

Common side effects

Diarrhea, nausea, vomiting, dry mouth, dizziness, insomnia

Rare/serious side effects

Night sweats, decreased appetite, migraine headaches, sleepiness, tremor, blurry vision, dry eyes, abnormal dreams, agitation, restlessness, increased urination, sexual dysfunction, angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye), Serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death), palpitations, irregular heartbeat

Vilazodone may increase the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this risk. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening.

Are There Any Risks For Taking Vilazodone For Long Periods Of Time?

To date, there are no known problems associated with long term use of vilazodone. It is a safe and effective medication when used as directed.

What Other Medications May Interact With Vilazodone?

Vilazodone should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azalect®) and selegiline (Emsam®).

Although rare, there is an increased risk of serotonin syndrome when vilazodone is used with other medications that increase serotonin, such as other antidepressants, migraine medications called “triptans” (e. g., Imitrex®), some pain medications (e.g., tramadol (Ultram®), and the antibiotic linezolid (Zyvox®).

The following medications may increase the levels and effects of vilazodone requiring decreased dose of vilazodone:

Antibiotics, such as clarithromycin (Biaxin®), erythromycin (Ery-Tab®), and telithromycin (Ketek®)

Antifungals, such as fluconazole (Diflucan®), ketoconazole (Nizoral®), and itraconazole (Sporanox®)

Blood pressure medications, such as verapamil (Calan®, Covera-HS®, Isoptin SR®) and diltiazem (Cardizem®, Tiazac®)

HIV medications such as protease inhibitors: indinavir (Crixivan®), ritonavir (Norvir®), saquinavir (Fortovase®, Invirase®), and lopinavir/ritonavir (Kaletra®)

Nefazodone

The following medications may decrease the levels and effects of vilazodone requiring increased dose of vilazodone: carbamazepine (Tegretol®), oxcarbazepine (Trileptal®), rifampin (Rifadin®), phenytoin (Dilantin®), and phenobarbital

How Long Does It Take For Vilazodone To Work?

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Summary of FDA Black Box Warnings

Suicidal thoughts or actions in children and adults

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications. This risk may persist until significant remission occurs.

In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. Adults age 65 and older taking antidepressants have a decreased risk of suicidality. Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or health care professional. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.

Provided by

(January 2023)

©2020 The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). AAPP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

This information is being provided as a community outreach effort of the American Association of Psychiatric Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The American Association of Psychiatric Pharmacists disclaims any and all liability alleged as a result of the information provided herein.

Vilazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Warnings:

Uses

Vilazodone is used to treat depression. It is an SSRI (selective serotonin reuptake inhibitor) and partial serotonin receptor agonist. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters such as serotonin). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

How to use Vilazodone 40 Mg Tablet Antidepressant Selective Serotonin Reuptake Inhib. (Ssris)

Read the Medication Guide provided by your pharmacist before you start taking vilazodone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Do not take more or less medication or take it more often than prescribed. Your condition will not improve any faster and your risk of side effects will increase.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as mood swings, headache, tiredness, sleep changes, ringing in the ears, seizures, numbness/tingling, “shock-like” feelings). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used vilazodone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Precautions

Before taking vilazodone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, personal or family history of suicide attempts, intestinal ulcers/bleeding (peptic ulcer disease), seizures, personal or family history of glaucoma (angle-closure type).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially bleeding. They are also more likely to develop a salt imbalance (hyponatremia), especially if they are also taking “water pills” (diuretics) with this medication. Salt imbalance can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated mental/mood problems (such as depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, “blood thinners” such as dabigatran/warfarin).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including other SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

This medication may interfere with certain medical/lab tests (such as brain scan for Parkinson’s disease), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Vilazodone 40 Mg Tablet Antidepressant Selective Serotonin Reuptake Inhib. (Ssris) interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Keep all regular medical and psychiatric appointments. Medical/psychiatric check-ups should be done periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.