Weight gain and fluoxetine: Does Prozac cause weight gain or loss?

16.05.202111.07.2023 by alexxlab

Содержание

Does Prozac cause weight gain or loss?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 17, 2023.

Initially, you may lose a small amount of weight, about 1 kg (2.2 lb) on average, when you first start taking Prozac, but over the long-term you may gain that weight back or even add on extra weight up to 6 kgs (13.2 lbs). Studies suggest this may be due to a recovery of your appetite after your symptoms subside. Weight changes may vary between patients, but in general Prozac is not usually associated with serious weight gain (over 7%).

In Prozac studies, weight loss has been reported in about 2% of patients (2 out of every 100), but patient self-reports of weight gain have been much higher, up to 37% in one survey.

Selective serotonin reuptake inhibitors (SSRIs) available in the U.S. include:

Celexa (citalopram)

Lexapro (escitalopram)

Prozac (fluoxetine)

Fluvoxamine (generic only)

Paxil (paroxetine)

Zoloft (sertraline)

Of all of the SSRIs, Prozac (fluoxetine) appears to be associated with the least chance for weight gain and Paxil (paroxetine) with the greatest chance. Paroxetine has been shown to lead to up to a 3.6% weight gain in about 6% of patients in one study. Other antidepressants, such the tricyclic antidepressants (TCAs) or mirtazapine can be associated with significant weight gain.

Why do weight changes occur with Prozac?

Weight gain

It is not fully clear if longer-term weight gain with selective serotonin reuptake inhibitors (SSRIs) is due to a drug side effect, the recovery of appetite after symptom recovery, or a mix of both. Short-term Prozac treatment for up to 3 months usually leads to little weight change, but most patients need medication for longer periods. Other reasons for weight gain with SSRIs may include genetic differences and increased carbohydrate cravings.

Weight loss

Weight loss during early treatment with Prozac may also be due to stomach (gastrointestinal) side effects. All SSRIs can cause some degree of short-term nausea and digestive tract discomfort when starting therapy or increasing the dose.

Over time, these common side effects tend to improve for most patients, but can include:

loss of appetite (4% to 17% of patients)

diarrhea (8% to 18% of patients)

nausea (12% to 29% of patients)

Patients with diabetes may have trouble with low blood sugar levels while taking Prozac, but blood sugar levels may increase when treatment is stopped. Your healthcare provider may need to adjust your dose of diabetes medications.

Other common side effects with SSRIs include sexual dysfunction, insomnia, headache, dry mouth, sedation, sweating, tremor, agitation and orthostatic hypotension (low blood pressure, dizziness when standing). Serious side effects like suicidal thoughts, bleeding, abnormal heart rhythms can also occur with SSRIs.

Studies: Weight Changes with Prozac

In studies looking at weight changes with Prozac (fluoxetine), weight loss has ranged from about 0.2% of body weight to a gain of about 1%.

Study 1

In a one-year randomized study, patients whose depressive symptoms had subsided after 12 weeks of treatment with fluoxetine 20 mg/day received either fluoxetine or a placebo (an inactive treatment) for 38 weeks. Weight changes were assessed during the initial 12 weeks of treatment and after 14, 26, and 38 weeks (for a total of 50 weeks).

During the initial 4 weeks of treatment, an average weight decrease of 0.4 kg (0.9 lb) was observed for all patients. After 50 weeks, weight increases were similar between the Prozac and placebo-treated groups. An average weight gain of 3 kg (6.6 lb) was observed over the entire 50-week period in the fluoxetine group, compared to 3.2 kg (7 lb) for the placebo group.

Weight gain was associated with a poor appetite at the beginning of treatment and an improved appetite after depressive symptoms cleared. Weight gain was not associated with the patient’s body weight at the start of the study.

No patients stopped Prozac treatment due to weight gain.

Study 2

In another study in 284 patients with major depressive disorder, long-term weight changes with Prozac were assessed when compared to paroxetine (Paxil) or sertraline (Zoloft), other commonly used SSRIs. Patients were evaluated for a total of 26 to 32 weeks.

Researchers looked at the average change in weight in each group and the number of patients with at least a 7% increase in weight from the start of the study.

Patients treated with paroxetine (Paxil) had a significant increase in weight, and those with a 7% or greater weight increase were highest in this group. Patients receiving fluoxetine (Prozac) or sertraline (Zoloft) had a modest but nonsignificant weight increase.

Bottom Line

Prozac is associated with a low amount of weight gain over the long- term compared to many SSRIs. Early in treatment, during the first few weeks it can cause a slight weight loss, but usually only about a pound or so.

It appears weight loss may be due to adverse stomach side effects like nausea or loss of appetite in the short-term, while weight gain may occur over the longer-term due to improved appetite and social functioning with improved mood.

If you are concerned about weight gain or loss with any antidepressant treatment, speak with your healthcare provider. There are many options to treat depression, some that have fewer side effects like weight gain. Do not stop treatment on your own without speaking to your healthcare provider.

This is not all the information you need to know about Prozac (fluoxetine) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Michelson D, Amsterdam JD, Quitkin FM, et al. Changes in weight during a 1-year trial of fluoxetine. Am J Psychiatry. 1999 Aug;156(8):1170-6. doi: 10.1176/ajp.156.8.1170.

Fava M, Judge R, Hoog SL, et al. Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry. 2000 Nov;61(11):863-7. doi: 10.4088/jcp.v61n1109.

Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010 Oct;71(10):1259-72. doi: 10.4088/JCP.09r05346blu.

Anagha K, Shihabudheen P, Uvais NA. Side Effect Profiles of Selective Serotonin Reuptake Inhibitors: A Cross-Sectional Study in a Naturalistic Setting. Prim Care Companion CNS Disord. 2021 Jul 29;23(4):20m02747. doi: 10.4088/PCC.20m02747.

Hirsch M (author). Selective serotonin reuptake inhibitors: Pharmacology, administration, and side effects. Up to Date. https://www.uptodate.com/contents/selective-serotonin-reuptake-inhibitors-pharmacology-administration-and-side-effects

Prozac Weekly. Professional. Prescribing information. Accessed Dec. 8, 2022 at https://www.drugs.com/pro/prozac-weekly.html#s-42231-1

Drug information

Prozac Information for Consumers
Prozac prescribing info & package insert
(for Health Professionals)
Side Effects of Prozac
(detailed)

Related support groups

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Medical Disclaimer

Changes in weight during a 1-year trial of fluoxetine

Clinical Trial

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

D Michelson¹, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliations

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

PMID:
10450256
DOI:
10.1176/ajp.156.8.1170

Clinical Trial

D Michelson et al.

Am J Psychiatry.

1999 Aug.

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

Authors

D Michelson¹, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

PMID:
10450256
DOI:
10.1176/ajp.156.8.1170

Abstract

Objective:

Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported. Weights were assessed for patients whose depressive symptoms had disappeared with acute fluoxetine treatment. Patients were then randomly assigned to continuation treatment with fluoxetine or placebo.

Method:

Patients whose illness had remitted after 12 weeks of treatment with fluoxetine, 20 mg/day, were randomly assigned to receive up to 38 weeks of treatment with fluoxetine or placebo. Weight was assessed at each visit. Change in weight was analyzed during the initial 12 weeks of acute treatment and after 14, 26, and 38 weeks. Relationships between weight change and body mass index and between weight change and appetite change were assessed.

Results:

During the initial 4 weeks of therapy, a mean absolute weight decrease of 0.4 kg was observed for all patients. Among patients who completed 50 weeks of therapy, the mean absolute weight increase during continuation treatment was similar for both the placebo- and fluoxetine-treated groups. Weight increase was not related to initial body mass index but was related to both poor appetite at study entry and to improvement in appetite after recovery. No patients discontinued therapy because of weight gain.

Conclusions:

Acute therapy with fluoxetine is associated with modest weight loss. After remission of depressive symptoms, weight gain for patients taking fluoxetine for longer periods is not different from that for patients taking placebo and is most likely related to recovery from depression.

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Serralde-Zuñiga AE, et al.
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Almotayri A, et al.
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PMID: 34408550
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Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion.
Carratalá-Ros C, López-Cruz L, Martínez-Verdú A, Olivares-García R, Salamone JD, Correa M.
Carratalá-Ros C, et al.
Front Behav Neurosci. 2021 Jul 9;15:700182. doi: 10.3389/fnbeh.2021.700182. eCollection 2021.
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Does Fluoxetine Really Lose Weight? Urgent need.

July 23, 2014 00:18

July 23, 2014 00:37

9 0015 July 23, 2014 00:59

July 23 2014 01:38

July 23, 2014 01:56

July 23, 2014 01:56 9 0004

Jul 23, 2014 01:56

July 23, 2014 04:11

90 057 July 23, 2014 08:32

#10

July 23 2014, 09:09

#11

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

July 23, 2014 09:18

#12

July 23, 2014 09:29

#13

July 23, 2014, 09:51

#14

Guest

Guest 11, why? For the purpose of losing weight?

Jul 23, 2014 10:57 AM

#15

Jul 23, 2014 12:28

#16

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

July 23, 2014, 2:18 pm

#17

mutka

plus

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

July 23, 2014 6:17 pm

#18

July 23, 2014 6:23 pm

#19

Misyusya

I have depression. Already treated three times. Now I’m rolling again. I took citalopram. Contains bromine. Calms down and I start to eat. I lost weight, but the kg returned. Therefore, I think, maybe ask the doctor to prescribe fluoxetine. I’m going to lose weight at the same time. there is nowhere to recover, the stomach does not go away. It’s disgusting to look at yourself.

July 23, 2014 6:39 PM

#20

July 24, 2014 12:38

#21

July 24, 2014 12:49 pm

#22

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

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24 July 2014, 15:13

#23

July 24, 2014 20:01

#24

July 24, 2014 21:38

#25 900 05 July 24, 2014 9:39 PM

#26

Guest

I also had depression, went to a psychiatrist and prescribed Prozac (just fluoxetine), but people took a quarter of a pill to him, and for some reason I didn’t lose a single gram, on the contrary, I ate from 54kg to 56-57!
But I felt so good, I went to bed at 21. 00 in the morning I woke up calm, my mood was normal, no bad emotions, though the good ones are not felt brightly!
in general will not help to lose weight!!!

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72 answers already. This is a drug for diabetics yet, but it is also really prescribed for those who need to lose weight. He reduces the amount of insulin there and the arms and legs do not shake and there are no thoughts about food when you want to eat. I now eat 2 tablets a day of Glucophage 850. But I’m on a diet and this drug just helps me not to get nervous if an attack of hunger or longing for a tasty treat comes over
February 18, 2015 6:46 pm
#29
June 15, 2015 3:34 pm
#30
August 20, 2015, 07:12 PM
#31
Author
I am depressed! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.
August 20, 2015 7:14 pm
#32
August 31, 2015, 21:37
#33
Guest
You may lose a couple of kilos, but you will quickly gain even more, fluoxitine has an unpleasant side effect, IT KILLS LIBIDO 90 005 December 17, 2015, 18:52
#34
Vera
Fluoxetine is a good drug and it really makes you lose weight.
#35
December 20, 2015 11:56 AM
#36
November 12, 2016 06:23 AM
#37
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  #41
  Author
  I’m depressed! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.
  Oct 05, 2017 07:18
  #42
  Nov 17, 2017 07:34
  #43
  Y awn
  I recently took it for weight loss, but considering that I have a lot of weight, yes and I was on a diet, I still didn’t lose weight, as I stopped taking the weight went down
  November 17, 2017, 07:41
  #45
  09 April 2018, 2:12 pm
  #47
  April 27, 2018, 00:16
  #47
  Guest
  Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.
  Attention
  April 27, 2018 00:32
  #47
  September 11, 2018 18:29
  #4 7
  Lital
  I take Fluox in the morning and in the evening. For a couple of months, 20 kg minus. During the day it works on mood and at night it has a fat burning effect.
  I’m shocked that antidepressants make you fat
  February 26, 2012 3:32 pm
  #1
  February 26, 2012 3:49 pm
  #2
  February 26, 2012, 03:50 PM
  #3
  I gained 4-5 kg after the first course in a few months, after the second course by the same amount. nothing..exactly 52kg, skinny…
  after antidepressants +8+10kg, now I have to limit myself
  February 26, 2012, 15:53
  #5
  Vaenga
  about how . I’m in the pharmacy for antidepressants! Author
  but these are not hormones! therefore, they don’t get fat, don’t invent.
  I never got better from anything.. never! didn’t play sports! lazy but love to eat! I didn’t get fat . . and exactly after taking antidepressants I got better!
  February 26, 2012, 04:17 PM
  #8
  by
  but these are not hormones! therefore, they don’t get fat, don’t invent.
  so don’t invent what you don’t know!
  26 February 2012, 16:19
  #9
  “SIDE EFFECTS: sedation, drowsiness, tardive dyskinesia (spasmodic torticollis, oculogeric crises, trismus, decreasing with administration anticholinergic antiparkinsonian drugs), extrapyramidal symptoms, the severity of which partially decreases with the appointment of anticholinergic antiparkinsonian drugs, tardive dyskinesia that develops with prolonged use of antipsychotics (anticholinergic antiparkinsonian drugs are ineffective and can worsen the patient’s condition), postural hypotension, impotence, frigidity, amenorrhea, galactorrhea, gynecomastia, hyperprolactinemia, weight gain.
  Feb 26, 2012 4:21 pm
  #10
  006 #11
  February 26, 2012 05:39 PM
  #12
  Feb 26, 2012, 20:40
  #13
  But from Grandaxin, she said weight gain is unlikely, I’ve been taking it for almost 2 months
  Feb 26 2 012, 20:46
  #14
  February 26, 2012, 8:49 pm
  #15
  author
  but these are not hormones! therefore, they don’t get fat, don’t invent.
  February 26, 2012, 20:53
  #16
  February 26, 2012, 21:31
  #17
  February 26, 2012 9:36 PM
  #18
  February 26 2012, 22:35
  #19
  Guest
  I hope I don’t have to take antidepressants anymore. If not for your thread, I would never have known that they get fat. I didn’t want sex, but everything is in order with the weight. I drank cipramil. Grandaxin is NOT an antidepressant.
  but when I stopped taking it, I climbed on the wall))
  gradaksin – generally grass in my opinion ..
  February 26, 2012, 23:48 5
  yes they get fat .. but you don’t did you know? the doctor also assured me that it was not so…
  I recovered after the first course in a few months by 4-5 kg, after the second course by the same amount. .
  I used to eat anything, cakes in the evening, dinner of three courses + a pie for sure and nothing ..exactly 52kg, skinny…
  after antidepressants +8+10kg, now I have to limit myself
  February 26, 2012, 23:49 4
  #22
  Lola
  Me too I was surprised when I found out, but consulted with my aunt (she is a doctor), it turns out that this is so, I was generally upset, some kind of vicious circle … (
  But from Grandaksin, she said, weight gain is unlikely, I have been taking it for almost 2 months
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  March 01, 2012, 01:53
  #23
  Guest
  and since when should antidepressants affect weight, or is it another duck, a psychological weapon, or the placebo effect, so they decided take revenge on the internet angry toast girls ?=) won’t work.
  The ex-husband took methylphenidate at first, therefore Ritalin. This is not quite a classic antidepressant, but he was prescribed it for depression (he had some kind of special one, I don’t understand these subtleties – there, in general, the devil will break his leg with these psychologists, you won’t check or prove anything). I put on about 20 kg. Sobsno, this is one of the main reasons why he became an ex.
  Pharmaceutics is as much a mafia as the drug trade. It is profitable for them to put people on all sorts of drugs that they will obediently buy all their lives and replenish the profits of world concerns.
  May 24, 2014 03:32 PM
  #24
  June 08, 2014 07:50 PM
  #25
  From some, nothing happens with weight.
  From some – individually (on paroxetine (Rexetin, Paxil), someone gets better, someone loses weight, someone, again, nothing).
  People often gain weight from neuroleptics, which many mistakenly refer to as antidepressants.
  As for the mechanism of action, indeed, antidepressants are not hormones (and are not addictive, in any case, SSRIs and SSRIs),
  BUT, since their action is based on a change in the level of neurotransmitters (serotonin, norepinephrine, dopamine), but the listed substances perform the function of not only neurotransmitters, but also hormones, they can affect appetite, libido, etc. (both increase and decrease). Trittiko and bupropion are prescribed for sexual dysfunction, Remeron also enhances libido, fluoxetine can nullify it. It all depends on which neurotransmitter and how the drug affects.
  June 08, 2014, 07:52 PM
  #26
  As the last commenter said, someone who has not had clinical depression (especially endogenous, not amenable to any psychotherapy type), somatoform disorder, diencephalic crises or severe panic attacks , do not understand why some are ready to “even” get fat, just to get rid of this nightmare. Sometimes it happens that only such an an-t is suitable that causes fullness or other side effects (the same Remeron is one of the most effective), but if there are more pluses and drugs can return to normal life, people usually choose to be healthy, albeit with a thick ass :).
  In general, an-you (I won’t tell you everything, but the last two generations for sure) are not some kind of “happiness and indifference pills” or substitutes for your own neurotransmitters, these are drugs that help the brain restore the production of necessary substances and then can be cancelled. It is also extremely difficult to pick them up: if you have depression from a lack of, say, dopamine, and you are combed one size fits all and you are prescribed serotonin fluoxetine, then an increase in depression is guaranteed. And venlafaxine can cause or intensify already existing pan-attacks.
  Sorry for the confusion, in general, I wanted to convey that there are completely different types of an-you.
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  - 9December 05 2014, 17:20
    #27
    Guest
    I was prescribed, from the first pill I felt hunger. Further more, it seems that you are constantly hungry, you want to eat, you don’t get enough .. eat eat eat . . you really want to eat .. so they get fat.
    December 07, 2014, 20:00
    #28
    12 April 2015 00:19
    #29
    12 July 2015 16:24
    #30
    July 22, 2015, 13:35
    #31
    Guest
    and since when should antidepressants affect weight, or is it another duck, a psychological weapon, or a placebo effect, so angry toasts decided to take revenge through the Internet? =) it won’t work.
    September 10, 2016, 18:06
    #32
    October 04, 2016, 20:58
    #33
    Guest
    and since when should antidepressants affect weight, or is it another duck, a psychological weapon, or the placebo effect – so they decided to take revenge through the Internet angry toast ears ?=) won’t work.
    March 05, 2017, 20:44
    #34
    Guest inet angry toast ?=) won’t work. 9G awn
    I was prescribed a feeling of hunger from the very first pill. Further more, it seems that you are constantly hungry, you want to eat, you don’t get enough .. eat eat eat .. you really want to eat .. so they get fat.
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    May 22, 2017, 22:55
    #37
    Guest ia and panic attacks, will never understand. I have been on adepress for a year, as a result, + 20 kg, but I feel good and there are no seizures. Here also choose. 9Victor iya
    Please tell me what antidepressants I drank I also had panic attacks I lost 10 kg I won’t get better can(((
    05 September 2017, 23:32
    #40
    08 October 2017, 17:04
    #41
    9 0002 October 30, 2017 08:59 AM
    #42
    12 January 2018, 23:34
    #43
    by
    but these are not hormones! therefore, they don’t get fat, don’t invent.
    January 20, 2018 03:16 PM
    #44
    March 05, 2018 05:12
    #45
    Iryna
    Not to invent?! Go, fields, what a smart one! Do you want 10kg a year? And hormonal failure and cyst, withdrawal effects too, beautiful? And then treat it all and look like a 40-year-old aunt at 27, is it bullshit too? I still, 2 years later, still very much regret that I accepted them.