About all

Weight gain and fluoxetine. Prozac and Weight Changes: Understanding the Impact on Body Mass

by alexxlab

Does Prozac cause weight gain or weight loss. How does fluoxetine affect body weight over time. What factors contribute to weight changes in patients taking Prozac. Are weight fluctuations common with SSRI antidepressants.

Содержание

The Initial Effects of Prozac on Body Weight

Prozac (fluoxetine) is a widely prescribed antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class. When patients first start taking Prozac, they may experience a small amount of weight loss, averaging around 1 kg (2.2 lbs). This initial weight reduction is often temporary and can be attributed to several factors.

Short-Term Weight Loss Factors

  • Gastrointestinal side effects
  • Reduced appetite
  • Nausea and digestive discomfort

These initial side effects typically subside as the body adjusts to the medication. It’s important to note that not all patients will experience weight loss when starting Prozac, and individual responses can vary significantly.

Long-Term Weight Changes Associated with Prozac

While short-term use of Prozac may lead to slight weight loss, long-term use can result in weight gain for some patients. Over time, individuals may regain the initial weight lost and potentially add extra weight, with some studies reporting gains of up to 6 kg (13.2 lbs).

Factors Contributing to Long-Term Weight Gain

  1. Recovery of appetite as depressive symptoms improve
  2. Potential metabolic changes
  3. Increased carbohydrate cravings
  4. Genetic predisposition

Is weight gain inevitable with long-term Prozac use? Not necessarily. Weight changes can vary greatly between patients, and Prozac is generally not associated with significant weight gain (over 7%) in most cases.

Comparing Prozac to Other SSRIs: Weight Gain Potential

When considering weight gain potential among SSRIs, Prozac (fluoxetine) is often regarded as one of the least likely to cause significant weight gain. Let’s compare it to other commonly prescribed SSRIs:

  • Celexa (citalopram)
  • Lexapro (escitalopram)
  • Fluvoxamine (generic only)
  • Paxil (paroxetine)
  • Zoloft (sertraline)

Among these options, Paxil (paroxetine) has been associated with the highest likelihood of weight gain, with some studies showing up to a 3.6% weight gain in about 6% of patients. In contrast, Prozac and Zoloft (sertraline) tend to have more modest effects on weight.

Mechanisms Behind Weight Changes with Prozac

The exact mechanisms responsible for weight changes in patients taking Prozac are not fully understood. However, several theories have been proposed to explain both weight gain and weight loss associated with the medication.

Potential Causes of Weight Gain

  • Restored appetite following symptom improvement
  • Alterations in metabolism
  • Changes in eating habits or food preferences
  • Hormonal fluctuations

Factors Contributing to Weight Loss

  • Gastrointestinal side effects (nausea, diarrhea)
  • Temporary loss of appetite
  • Increased energy levels leading to higher physical activity

Do these weight changes affect all patients equally? No, the impact of Prozac on weight can vary significantly from person to person, influenced by factors such as individual physiology, lifestyle, and concurrent medical conditions.

Research Findings on Prozac and Weight Changes

Several studies have investigated the relationship between Prozac use and weight changes. Let’s examine two key studies that provide insights into this topic:

Study 1: Long-Term Weight Changes in Fluoxetine Treatment

This one-year randomized study followed patients whose depressive symptoms had improved after 12 weeks of fluoxetine treatment (20 mg/day). Participants were then given either fluoxetine or a placebo for an additional 38 weeks.

  • Initial 4 weeks: Average weight decrease of 0.4 kg (0.9 lb) observed
  • After 50 weeks: Similar weight increases in both fluoxetine and placebo groups
  • Fluoxetine group: Average weight gain of 3 kg (6.6 lb) over 50 weeks
  • Placebo group: Average weight gain of 3.2 kg (7 lb) over 50 weeks

What factors were associated with weight gain in this study? Poor appetite at the beginning of treatment and improved appetite after depressive symptoms cleared were linked to weight gain. Importantly, no patients discontinued Prozac treatment due to weight gain.

Study 2: Comparative Analysis of SSRIs and Weight Changes

This study involved 284 patients with major depressive disorder and compared long-term weight changes among Prozac (fluoxetine), Paxil (paroxetine), and Zoloft (sertraline) over 26 to 32 weeks.

  • Paxil (paroxetine) group: Significant increase in weight, highest percentage of patients with ≥7% weight gain
  • Prozac (fluoxetine) group: Modest, non-significant weight increase
  • Zoloft (sertraline) group: Modest, non-significant weight increase

What conclusions can we draw from these studies? Prozac appears to have a relatively low impact on long-term weight gain compared to some other SSRIs, particularly Paxil.

Managing Weight Changes While Taking Prozac

For patients concerned about potential weight changes while taking Prozac, there are several strategies that can help manage body weight:

  1. Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains
  2. Engage in regular physical activity, aiming for at least 150 minutes of moderate exercise per week
  3. Monitor portion sizes and practice mindful eating
  4. Stay hydrated by drinking plenty of water throughout the day
  5. Get adequate sleep, as poor sleep can affect metabolism and hunger hormones
  6. Discuss any concerns about weight changes with your healthcare provider

Can lifestyle modifications completely prevent weight changes associated with Prozac? While these strategies can help mitigate weight fluctuations, it’s important to remember that some changes may still occur due to the medication’s effects on the body.

Special Considerations for Prozac and Weight Changes

Certain patient populations may require additional monitoring or considerations when it comes to Prozac use and weight changes:

Patients with Diabetes

Individuals with diabetes may experience fluctuations in blood sugar levels while taking Prozac. In some cases, blood sugar levels may decrease during treatment but increase when the medication is discontinued. Close monitoring and potential adjustments to diabetes medications may be necessary.

Patients with a History of Eating Disorders

For individuals with a history of eating disorders, any changes in weight or appetite should be closely monitored. The initial appetite suppression effects of Prozac may be concerning for those with a history of anorexia, while potential long-term weight gain could be distressing for those with a history of binge eating disorder.

Adolescents and Young Adults

Young patients may be particularly sensitive to weight changes, both physically and emotionally. Healthcare providers should discuss potential weight fluctuations with these patients and their caregivers, emphasizing the importance of overall mental health and well-being.

How can healthcare providers address weight concerns in these special populations? Regular check-ins, comprehensive monitoring of both mental health symptoms and physical health markers, and open communication about any concerns are crucial for ensuring optimal care.

Beyond Weight: Other Side Effects of Prozac

While weight changes are a notable concern for many patients, it’s important to consider the full spectrum of potential side effects associated with Prozac:

Common Side Effects

  • Sexual dysfunction (e.g., decreased libido, difficulty achieving orgasm)
  • Insomnia or changes in sleep patterns
  • Headaches
  • Dry mouth
  • Excessive sweating
  • Tremors or jitteriness
  • Fatigue or drowsiness

Less Common but Serious Side Effects

  • Increased risk of suicidal thoughts, especially in young adults and adolescents
  • Serotonin syndrome, a potentially life-threatening condition
  • Increased risk of bleeding, especially when combined with certain medications
  • Hyponatremia (low sodium levels in the blood)
  • Manic episodes in patients with bipolar disorder

Are these side effects reasons to avoid Prozac altogether? Not necessarily. For many patients, the benefits of Prozac in treating depression and other mental health conditions outweigh the potential risks. However, it’s crucial for patients to discuss all potential side effects with their healthcare provider and report any concerning symptoms promptly.

Balancing Mental Health and Physical Well-being

When considering the impact of Prozac on weight and overall health, it’s essential to maintain perspective on the primary goal of treatment: improving mental health and quality of life. For many patients, the relief from depressive symptoms far outweighs concerns about modest weight changes.

Strategies for Holistic Well-being

  1. Focus on overall health rather than just weight
  2. Engage in activities that promote both mental and physical health, such as yoga or nature walks
  3. Practice stress-reduction techniques like meditation or deep breathing exercises
  4. Seek support from mental health professionals, support groups, or trusted friends and family
  5. Maintain open communication with your healthcare provider about both mental and physical health concerns

How can patients strike a balance between managing their mental health and physical well-being? The key lies in adopting a holistic approach to health, addressing both mental and physical aspects with equal importance. This may involve working with a team of healthcare professionals, including a psychiatrist, therapist, and primary care physician, to ensure comprehensive care.

Alternative Treatment Options for Depression

For patients who are particularly concerned about weight changes or other side effects associated with Prozac, there may be alternative treatment options to consider:

Other Antidepressant Medications

  • Other SSRIs with potentially different side effect profiles
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Atypical antidepressants like bupropion, which is less likely to cause weight gain
  • Tricyclic antidepressants (TCAs), although these may be associated with more significant weight gain

Non-Pharmacological Approaches

  • Cognitive-behavioral therapy (CBT)
  • Interpersonal therapy
  • Electroconvulsive therapy (ECT) for severe, treatment-resistant depression
  • Transcranial magnetic stimulation (TMS)
  • Light therapy, particularly for seasonal affective disorder

Can these alternatives completely replace Prozac for all patients? No, the effectiveness of different treatments can vary greatly between individuals. The choice of treatment should be made in consultation with a healthcare provider, taking into account the patient’s specific symptoms, medical history, and personal preferences.

The Importance of Individualized Treatment Plans

When it comes to treating depression and managing potential side effects like weight changes, there is no one-size-fits-all approach. Each patient’s experience with Prozac and other antidepressants can be unique, influenced by factors such as:

  • Genetic predisposition
  • Individual physiology
  • Severity and type of depression
  • Concurrent medical conditions
  • Lifestyle factors
  • Personal preferences and values

How can healthcare providers ensure the most effective and well-tolerated treatment for each patient? By adopting a personalized medicine approach, which may include:

  1. Thorough initial assessment of the patient’s mental and physical health
  2. Regular follow-ups to monitor progress and side effects
  3. Flexibility in adjusting treatment plans as needed
  4. Consideration of pharmacogenetic testing to guide medication choices
  5. Integration of complementary therapies and lifestyle modifications

This individualized approach can help maximize the benefits of treatment while minimizing unwanted side effects, including weight changes.

The Role of Patient Education and Empowerment

Empowering patients with knowledge about their medication, potential side effects, and strategies for managing their overall health is crucial for successful treatment outcomes. Healthcare providers can support patient empowerment by:

  • Providing clear, comprehensive information about Prozac and its effects
  • Discussing realistic expectations for treatment outcomes and timelines
  • Offering guidance on lifestyle modifications to support mental and physical health
  • Encouraging patients to actively participate in treatment decisions
  • Providing resources for further education and support

How can patients take an active role in managing their treatment and potential side effects? By staying informed, maintaining open communication with their healthcare team, and advocating for their needs and concerns throughout the treatment process.

Future Directions in Antidepressant Research and Development

As our understanding of depression and its treatment continues to evolve, researchers are exploring new avenues for developing antidepressants with improved efficacy and reduced side effects, including weight changes. Some promising areas of research include:

  • Novel drug targets beyond serotonin and norepinephrine
  • Personalized medicine approaches using genetic and biomarker data
  • Combination therapies that address multiple aspects of depression
  • Development of rapid-acting antidepressants
  • Exploration of non-pharmacological interventions, such as neurostimulation techniques

What potential impact could these advancements have on the treatment of depression? Future developments may lead to more targeted, effective treatments with fewer side effects, potentially reducing concerns about weight changes and other adverse effects associated with current antidepressants like Prozac.

As research progresses, it’s important for patients and healthcare providers to stay informed about new developments and consider how emerging treatments might fit into individualized treatment plans. However, it’s equally crucial to remember that Prozac remains an effective and well-studied option for many patients, and decisions about treatment should always be made in consultation with a qualified healthcare professional.

Does Prozac cause weight gain or loss?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 17, 2023.

Initially, you may lose a small amount of weight, about 1 kg (2.2 lb) on average, when you first start taking Prozac, but over the long-term you may gain that weight back or even add on extra weight up to 6 kgs (13.2 lbs). Studies suggest this may be due to a recovery of your appetite after your symptoms subside. Weight changes may vary between patients, but in general Prozac is not usually associated with serious weight gain (over 7%).

In Prozac studies, weight loss has been reported in about 2% of patients (2 out of every 100), but patient self-reports of weight gain have been much higher, up to 37% in one survey.

Selective serotonin reuptake inhibitors (SSRIs) available in the U.S. include:

  • Celexa (citalopram)

  • Lexapro (escitalopram)

  • Prozac (fluoxetine)

  • Fluvoxamine (generic only)

  • Paxil (paroxetine)

  • Zoloft (sertraline)

Of all of the SSRIs, Prozac (fluoxetine) appears to be associated with the least chance for weight gain and Paxil (paroxetine) with the greatest chance. Paroxetine has been shown to lead to up to a 3.6% weight gain in about 6% of patients in one study. Other antidepressants, such the tricyclic antidepressants (TCAs) or mirtazapine can be associated with significant weight gain.

Why do weight changes occur with Prozac?

Weight gain

It is not fully clear if longer-term weight gain with selective serotonin reuptake inhibitors (SSRIs) is due to a drug side effect, the recovery of appetite after symptom recovery, or a mix of both. Short-term Prozac treatment for up to 3 months usually leads to little weight change, but most patients need medication for longer periods. Other reasons for weight gain with SSRIs may include genetic differences and increased carbohydrate cravings.

Weight loss

Weight loss during early treatment with Prozac may also be due to stomach (gastrointestinal) side effects. All SSRIs can cause some degree of short-term nausea and digestive tract discomfort when starting therapy or increasing the dose.

Over time, these common side effects tend to improve for most patients, but can include:

  • loss of appetite (4% to 17% of patients)

  • diarrhea (8% to 18% of patients)

  • nausea (12% to 29% of patients)

Patients with diabetes may have trouble with low blood sugar levels while taking Prozac, but blood sugar levels may increase when treatment is stopped. Your healthcare provider may need to adjust your dose of diabetes medications.

Other common side effects with SSRIs include sexual dysfunction, insomnia, headache, dry mouth, sedation, sweating, tremor, agitation and orthostatic hypotension (low blood pressure, dizziness when standing). Serious side effects like suicidal thoughts, bleeding, abnormal heart rhythms can also occur with SSRIs.

Studies: Weight Changes with Prozac

In studies looking at weight changes with Prozac (fluoxetine), weight loss has ranged from about 0.2% of body weight to a gain of about 1%.

Study 1

In a one-year randomized study, patients whose depressive symptoms had subsided after 12 weeks of treatment with fluoxetine 20 mg/day received either fluoxetine or a placebo (an inactive treatment) for 38 weeks. Weight changes were assessed during the initial 12 weeks of treatment and after 14, 26, and 38 weeks (for a total of 50 weeks).

  • During the initial 4 weeks of treatment, an average weight decrease of 0.4 kg (0.9 lb) was observed for all patients. After 50 weeks, weight increases were similar between the Prozac and placebo-treated groups. An average weight gain of 3 kg (6.6 lb) was observed over the entire 50-week period in the fluoxetine group, compared to 3.2 kg (7 lb) for the placebo group.

  • Weight gain was associated with a poor appetite at the beginning of treatment and an improved appetite after depressive symptoms cleared. Weight gain was not associated with the patient’s body weight at the start of the study.

  • No patients stopped Prozac treatment due to weight gain.

Study 2

In another study in 284 patients with major depressive disorder, long-term weight changes with Prozac were assessed when compared to paroxetine (Paxil) or sertraline (Zoloft), other commonly used SSRIs. Patients were evaluated for a total of 26 to 32 weeks.

  • Researchers looked at the average change in weight in each group and the number of patients with at least a 7% increase in weight from the start of the study.

  • Patients treated with paroxetine (Paxil) had a significant increase in weight, and those with a 7% or greater weight increase were highest in this group. Patients receiving fluoxetine (Prozac) or sertraline (Zoloft) had a modest but nonsignificant weight increase.

Bottom Line

  • Prozac is associated with a low amount of weight gain over the long- term compared to many SSRIs. Early in treatment, during the first few weeks it can cause a slight weight loss, but usually only about a pound or so.

  • It appears weight loss may be due to adverse stomach side effects like nausea or loss of appetite in the short-term, while weight gain may occur over the longer-term due to improved appetite and social functioning with improved mood.

  • If you are concerned about weight gain or loss with any antidepressant treatment, speak with your healthcare provider. There are many options to treat depression, some that have fewer side effects like weight gain. Do not stop treatment on your own without speaking to your healthcare provider.

This is not all the information you need to know about Prozac (fluoxetine) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

  • Michelson D, Amsterdam JD, Quitkin FM, et al. Changes in weight during a 1-year trial of fluoxetine. Am J Psychiatry. 1999 Aug;156(8):1170-6. doi: 10.1176/ajp.156.8.1170. 

  • Fava M, Judge R, Hoog SL, et al. Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry. 2000 Nov;61(11):863-7. doi: 10.4088/jcp.v61n1109. 

  • Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010 Oct;71(10):1259-72. doi: 10.4088/JCP.09r05346blu. 

  • Anagha K, Shihabudheen P, Uvais NA. Side Effect Profiles of Selective Serotonin Reuptake Inhibitors: A Cross-Sectional Study in a Naturalistic Setting. Prim Care Companion CNS Disord. 2021 Jul 29;23(4):20m02747. doi: 10.4088/PCC.20m02747. 

  • Hirsch M (author). Selective serotonin reuptake inhibitors: Pharmacology, administration, and side effects. Up to Date. https://www.uptodate.com/contents/selective-serotonin-reuptake-inhibitors-pharmacology-administration-and-side-effects

  • Prozac Weekly. Professional. Prescribing information. Accessed Dec. 8, 2022 at https://www.drugs.com/pro/prozac-weekly.html#s-42231-1

Related medical questions

  • SSRI’s vs SNRI’s – What’s the difference between them?
  • What does Prozac feel like when it starts working?
  • Can antidepressants be used for arthritis pain?
  • How long does it take for Prozac to work?
  • Is Prozac a controlled substance / addictive?
  • Prozac vs Zoloft – What are the Differences & Similarities?
  • What are some common side effects of antidepressants?
  • Is Prozac (fluoxetine) safe for dogs?
  • Taking fluoxetine, what can I use for a bad cough from cold or strep throat?
  • Is obesity a major risk factor for Covid-19?
  • How do Mounjaro, Wegovy & Ozempic compare for weight loss?

Drug information

  • Prozac Information for Consumers
  • Prozac prescribing info & package insert
    (for Health Professionals)
  • Side Effects of Prozac
    (detailed)

Related support groups

  • Prozac
    (252 questions, 1,097 members)
  • Weight Loss (Obesity/Overweight)
    (706 questions, 1,439 members)

Medical Disclaimer

Changes in weight during a 1-year trial of fluoxetine

Clinical Trial

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

D Michelson 
1
, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliations

Affiliation

  • 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

  • PMID:

    10450256

  • DOI:

    10.1176/ajp.156.8.1170

Clinical Trial

D Michelson et al.

Am J Psychiatry.

1999 Aug.

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

Authors

D Michelson 
1
, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliation

  • 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

  • PMID:

    10450256

  • DOI:

    10.1176/ajp.156.8.1170

Abstract


Objective:

Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported. Weights were assessed for patients whose depressive symptoms had disappeared with acute fluoxetine treatment. Patients were then randomly assigned to continuation treatment with fluoxetine or placebo.


Method:

Patients whose illness had remitted after 12 weeks of treatment with fluoxetine, 20 mg/day, were randomly assigned to receive up to 38 weeks of treatment with fluoxetine or placebo. Weight was assessed at each visit. Change in weight was analyzed during the initial 12 weeks of acute treatment and after 14, 26, and 38 weeks. Relationships between weight change and body mass index and between weight change and appetite change were assessed.


Results:

During the initial 4 weeks of therapy, a mean absolute weight decrease of 0.4 kg was observed for all patients. Among patients who completed 50 weeks of therapy, the mean absolute weight increase during continuation treatment was similar for both the placebo- and fluoxetine-treated groups. Weight increase was not related to initial body mass index but was related to both poor appetite at study entry and to improvement in appetite after recovery. No patients discontinued therapy because of weight gain.


Conclusions:

Acute therapy with fluoxetine is associated with modest weight loss. After remission of depressive symptoms, weight gain for patients taking fluoxetine for longer periods is not different from that for patients taking placebo and is most likely related to recovery from depression.

Similar articles

  • Fluoxetine: a randomized clinical trial in the maintenance of weight loss.

    Goldstein DJ, Rampey AH Jr, Dornseif BE, Levine LR, Potvin JH, Fludzinski LA.

    Goldstein DJ, et al.
    Obes Res. 1993 Mar;1(2):92-8. doi: 10.1002/j.1550-8528.1993.tb00597.x.
    Obes Res. 1993.

    PMID: 16350565

    Clinical Trial.

  • Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment.

    Fava M, Judge R, Hoog SL, Nilsson ME, Koke SC.

    Fava M, et al.
    J Clin Psychiatry. 2000 Nov;61(11):863-7. doi: 10.4088/jcp.v61n1109.
    J Clin Psychiatry. 2000.

    PMID: 11105740

    Clinical Trial.

  • Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study.

    Robinson RG, Schultz SK, Castillo C, Kopel T, Kosier JT, Newman RM, Curdue K, Petracca G, Starkstein SE.

    Robinson RG, et al.
    Am J Psychiatry. 2000 Mar;157(3):351-9. doi: 10.1176/appi.ajp.157.3.351.
    Am J Psychiatry. 2000.

    PMID: 10698809

    Clinical Trial.

  • Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis.

    Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Kim C, Lau J.

    Norris SL, et al.
    Arch Intern Med. 2004 Jul 12;164(13):1395-404. doi: 10.1001/archinte.164.13.1395.
    Arch Intern Med. 2004.

    PMID: 15249348

    Review.

  • Fluoxetine: a suitable long-term treatment.

    Calil HM.

    Calil HM.
    J Clin Psychiatry. 2001;62 Suppl 22:24-9.
    J Clin Psychiatry. 2001.

    PMID: 11599644

    Review.

See all similar articles

Cited by

  • Use of Fluoxetine to Reduce Weight in Adults with Overweight or Obesity: Abridged Republication of the Cochrane Systematic Review.

    Serralde-Zuñiga AE, González-Garay AG, Rodríguez-Carmona Y, Meléndez-Mier G.

    Serralde-Zuñiga AE, et al.
    Obes Facts. 2022;15(4):473-486. doi: 10.1159/000524995. Epub 2022 Jun 2.
    Obes Facts. 2022.

    PMID: 35654016
    Free PMC article.

  • Serotonin transporter is negatively associated with body mass index after glucose loading in humans.

    Pak K, Kim K, Seo S, Lee MJ, Kim IJ.

    Pak K, et al.
    Brain Imaging Behav. 2022 Jun;16(3):1246-1251. doi: 10.1007/s11682-021-00600-x. Epub 2022 Jan 3.
    Brain Imaging Behav. 2022.

    PMID: 34981428

  • A Focus on Evaluating Major Study Limitations in Order to Apply Clinical Trials to Patient Care: Implications for the Healthcare Team.

    Ferrill MJ, FakhriRavari A, Hong L, Wedret JJ.

    Ferrill MJ, et al.
    Hosp Pharm. 2021 Oct;56(5):597-603. doi: 10.1177/0018578720931750. Epub 2020 Jun 2.
    Hosp Pharm. 2021.

    PMID: 34720166
    Free PMC article.

  • Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism Caenorhabditis elegans.

    Almotayri A, Thomas J, Munasinghe M, Weerasinghe M, Heydarian D, Jois M.

    Almotayri A, et al.
    Saudi Pharm J. 2021 Aug;29(8):917-929. doi: 10.1016/j.jsps.2021.07.006. Epub 2021 Jul 16.
    Saudi Pharm J. 2021.

    PMID: 34408550
    Free PMC article.

  • Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion.

    Carratalá-Ros C, López-Cruz L, Martínez-Verdú A, Olivares-García R, Salamone JD, Correa M.

    Carratalá-Ros C, et al.
    Front Behav Neurosci. 2021 Jul 9;15:700182. doi: 10.3389/fnbeh.2021.700182. eCollection 2021.
    Front Behav Neurosci. 2021.

    PMID: 34305547
    Free PMC article.

See all “Cited by” articles

Publication types

MeSH terms

Substances

Does Fluoxetine Really Lose Weight? Urgent need.

#1

#2

9 0015 July 23, 2014 00:59

#3

#4

#5

#6

#7

#8

#9

90 057 July 23, 2014 08:32

#10

#11

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

#12

#13

#14

Guest

Guest 11, why? For the purpose of losing weight?

#15

#16

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

#17

mutka

plus

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

#18

#19

Misyusya

I have depression. Already treated three times. Now I’m rolling again. I took citalopram. Contains bromine. Calms down and I start to eat. I lost weight, but the kg returned. Therefore, I think, maybe ask the doctor to prescribe fluoxetine. I’m going to lose weight at the same time. there is nowhere to recover, the stomach does not go away. It’s disgusting to look at yourself.

#20

#21

#22

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

Woman.ru experts

  • Shakhova Natali

    Psychologist-consultant

    37 responses

  • Richter Tatyana Sergeevna

    Family psychologist

    1 answer

  • Sadovnikov Ernest

    Psychologist….

    254 answers

  • Oksana Nosachenko

    Psychologist

    38 answers

  • Markov Oleg Anatolyevich

    Weight management specialist

    4 answers

  • Nina Babanakova

    Nutritionist, consultant on. ..

    91 answers

  • Yulia Lekomtseva

    Cosmetologist

    289 answers

  • Sergey Katyshev

    Nutritionist

    152 answers

  • Arkhipova Maria

    Coach. I work in a personal niche …

    2 answers

  • Dmitry Olegovich Surotkin

    Psychotherapist

    41 answers

#23

#24

#25 900 05

#26

Guest

I also had depression, went to a psychiatrist and prescribed Prozac (just fluoxetine), but people took a quarter of a pill to him, and for some reason I didn’t lose a single gram, on the contrary, I ate from 54kg to 56-57!
But I felt so good, I went to bed at 21. 00 in the morning I woke up calm, my mood was normal, no bad emotions, though the good ones are not felt brightly!
in general will not help to lose weight!!!

Unthinkable stories

  • Husband doesn’t want to cook

    385 answers

  • 5

    588 responses

  • My husband left six months ago, alone with my daughter, I can’t forget

    81 answers

  • How to continue to live if my husband loves me only for beauty?

    201 answer

  • Daughter. Fear that one day she won’t want to live with me

    5 answers

#29

#30

#31

Author

I am depressed! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.

#32

#33

Guest

You may lose a couple of kilos, but you will quickly gain even more, fluoxitine has an unpleasant side effect, IT KILLS LIBIDO 90 005

#34

Vera

Fluoxetine is a good drug and it really makes you lose weight.

#35

#36

#37

New Topics 9000 5

  • How to love yourself? How to love yourself?

    No answers

  • Wash out fast

    No responses

  • Unrequited love

    1 reply

#38

#39

#40

#41

Author

I am depressed ! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.

#42

#43

Y awn

I recently took it for weight loss, but considering that I have a lot of weight, yes and I was on a diet, I still didn’t lose weight, as I stopped taking the weight went down

#45

#47

#47

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

Attention

#47

#4 7

Lital

I take Fluox in the morning and in the evening. For a couple of months, 20 kg minus. During the day it works on mood and at night it has a fat burning effect.

I’m shocked that antidepressants make you fat

#1

#2

#3

I gained 4-5 kg ​​after the first course in a few months, after the second course by the same amount. nothing..exactly 52kg, skinny…

after antidepressants +8+10kg, now I have to limit myself

#5

Vaenga

about how . I’m in the pharmacy for antidepressants! Author

but these are not hormones! therefore, they don’t get fat, don’t invent.

I never got better from anything.. never! didn’t play sports! lazy but love to eat! I didn’t get fat . . and exactly after taking antidepressants I got better!

#8

by

but these are not hormones! therefore, they don’t get fat, don’t invent.

so don’t invent what you don’t know!

#9

“SIDE EFFECTS: sedation, drowsiness, tardive dyskinesia (spasmodic torticollis, oculogeric crises, trismus, decreasing with administration anticholinergic antiparkinsonian drugs), extrapyramidal symptoms, the severity of which partially decreases with the appointment of anticholinergic antiparkinsonian drugs, tardive dyskinesia that develops with prolonged use of antipsychotics (anticholinergic antiparkinsonian drugs are ineffective and can worsen the patient’s condition), postural hypotension, impotence, frigidity, amenorrhea, galactorrhea, gynecomastia, hyperprolactinemia, weight gain.

#10

006 #11

#12

#13

But from Grandaxin, she said weight gain is unlikely, I’ve been taking it for almost 2 months

#14

#15

author

but these are not hormones! therefore, they don’t get fat, don’t invent.

#16

#17

#18

#19

Guest

I hope I don’t have to take antidepressants anymore. If not for your thread, I would never have known that they get fat. I didn’t want sex, but everything is in order with the weight. I drank cipramil. Grandaxin is NOT an antidepressant.

but when I stopped taking it, I climbed on the wall))

gradaksin – generally grass in my opinion ..

yes they get fat .. but you don’t did you know? the doctor also assured me that it was not so…

I recovered after the first course in a few months by 4-5 kg, after the second course by the same amount. .

I used to eat anything, cakes in the evening, dinner of three courses + a pie for sure and nothing ..exactly 52kg, skinny…

after antidepressants +8+10kg, now I have to limit myself

#22

Lola

Me too I was surprised when I found out, but consulted with my aunt (she is a doctor), it turns out that this is so, I was generally upset, some kind of vicious circle … (

But from Grandaksin, she said, weight gain is unlikely, I have been taking it for almost 2 months

Woman.ru experts

  • Shakhova Natali

    Psychologist-consultant

    37 answers

  • Richter Tatyana Sergeevna

    Family psychologist

    1 answer

  • Sadovnikov Ernest

    Psychologist . …

    254 answers

  • Oksana Nosachenko

    Psychologist

    38 answers

  • Markov Oleg Anatolyevich

    Weight correction specialist

    4 answers

  • Nina Babanakova

    Nutritionist, consultant on…

    91 answers

  • Julia Lekomtseva

    Cosmetologist

    289 answers

  • Sergey Katyshev

    Nutritionist

    152 answers

  • Arkhipova Maria

    Coach. I work in a personal niche …

    2 answers

  • Dmitry Olegovich Surotkin

    Psychotherapist

    41 answers

#23

Guest

and since when should antidepressants affect weight, or is it another duck, a psychological weapon, or the placebo effect, so they decided take revenge on the internet angry toast girls ?=) won’t work.

The ex-husband took methylphenidate at first, therefore Ritalin. This is not quite a classic antidepressant, but he was prescribed it for depression (he had some kind of special one, I don’t understand these subtleties – there, in general, the devil will break his leg with these psychologists, you won’t check or prove anything). I put on about 20 kg. Sobsno, this is one of the main reasons why he became an ex.

Pharmaceutics is as much a mafia as the drug trade. It is profitable for them to put people on all sorts of drugs that they will obediently buy all their lives and replenish the profits of world concerns.

#24

#25

From some, nothing happens with weight.
From some – individually (on paroxetine (Rexetin, Paxil), someone gets better, someone loses weight, someone, again, nothing).

People often gain weight from neuroleptics, which many mistakenly refer to as antidepressants.

As for the mechanism of action, indeed, antidepressants are not hormones (and are not addictive, in any case, SSRIs and SSRIs),
BUT, since their action is based on a change in the level of neurotransmitters (serotonin, norepinephrine, dopamine), but the listed substances perform the function of not only neurotransmitters, but also hormones, they can affect appetite, libido, etc. (both increase and decrease). Trittiko and bupropion are prescribed for sexual dysfunction, Remeron also enhances libido, fluoxetine can nullify it. It all depends on which neurotransmitter and how the drug affects.

#26

As the last commenter said, someone who has not had clinical depression (especially endogenous, not amenable to any psychotherapy type), somatoform disorder, diencephalic crises or severe panic attacks , do not understand why some are ready to “even” get fat, just to get rid of this nightmare. Sometimes it happens that only such an an-t is suitable that causes fullness or other side effects (the same Remeron is one of the most effective), but if there are more pluses and drugs can return to normal life, people usually choose to be healthy, albeit with a thick ass :).

In general, an-you (I won’t tell you everything, but the last two generations for sure) are not some kind of “happiness and indifference pills” or substitutes for your own neurotransmitters, these are drugs that help the brain restore the production of necessary substances and then can be cancelled. It is also extremely difficult to pick them up: if you have depression from a lack of, say, dopamine, and you are combed one size fits all and you are prescribed serotonin fluoxetine, then an increase in depression is guaranteed. And venlafaxine can cause or intensify already existing pan-attacks.

Sorry for the confusion, in general, I wanted to convey that there are completely different types of an-you.

Uninvented stories

  • Husband mocks and won’t let go

    51 answers

  • Fell in love with aunt

    90 How to to get rid of the man-burden?

    28 responses

  • Rented an apartment to a pervert!

    54 answers

#28

#29

#31

Guest

should, or is it another duck, a psychological weapon, or a placebo effect, so they decided to take revenge through the Internet angry toast? =) will not work.

#32

#33

Guest

and since when should antidepressants affect weight, or is it another duck, a psychological weapon, or a placebo effect – so angry toast girls decided to take revenge through the Internet? =) will not work.

#34

Guest inet angry toast ?=) won’t work. 9G awn

I was prescribed a feeling of hunger from the very first pill. Further more, it seems that you are constantly hungry, you want to eat, you don’t get enough .. eat eat eat .. you really want to eat .. so they get fat.

New themes

  • How to love yourself?

    1 answer0282

    1 answer

  • How to love yourself?

    No answers

  • Paint washes out quickly

    No answers

  • Unrequited love

    9000 5

    1 reply

Those who have not suffered from depression and panic attacks will never understand. I have been on adepress for a year, as a result, + 20 kg, but I feel good and there are no seizures. Here also choose. 9Victor iya

Please tell me what antidepressants I drank I also had panic attacks I lost 10 kg I won’t get better can(((

#40

#41

9 0002

#42

#43

by

but these are not hormones! therefore, they don’t get fat, don’t invent.