Irbesartan (Oral Route) Side Effects

Side Effects

Drug information provided by: IBM Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. 
   Chills
2. 
   cold sweats
3. 
   confusion
4. 
   dizziness, faintness, or lightheadedness when getting up from lying or sitting position

Less common

1. 
   Bladder pain
2. 
   bloody or cloudy urine
3. 
   chest pain
4. 
   difficult, burning, or painful urination
5. 
   fast, pounding, or irregular heartbeat or pulse
6. 
   frequent urge to urinate
7. 
   lower back or side pain

Rare

1. 
   Chest discomfort
2. 
   decreased urine output
3. 
   dilated neck veins
4. 
   extreme fatigue
5. 
   feeling of warmth
6. 
   fever
7. 
   irregular breathing
8. 
   irregular heartbeat
9. 
   nausea
10. 
    pain or discomfort in the arms, jaw, back, or neck
11. 
    redness of the face, neck, arms, and occasionally, upper chest
12. 
    shortness of breath
13. 
    sweating
14. 
    swelling of the face, fingers, feet, or lower legs
15. 
    tightness in the chest
16. 
    troubled breathing
17. 
    vomiting
18. 
    weight gain

Incidence not known

1. 
   Abdominal or stomach pain
2. 
   black, tarry stools
3. 
   bleeding gums
4. 
   clay-colored stools
5. 
   dark urine
6. 
   decreased frequency of urine
7. 
   headache
8. 
   increased thirst
9. 
   itching
10. 
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
11. 
    loss of appetite
12. 
    muscle cramps or spasms
13. 
    muscle pain or stiffness
14. 
    nervousness
15. 
    numbness or tingling in the hands, feet, or lips
16. 
    pinpoint red spots on the skin
17. 
    rash
18. 
    unpleasant breath odor
19. 
    unusual bleeding or bruising
20. 
    unusual tiredness or weakness
21. 
    vomiting of blood
22. 
    weakness or heaviness of the legs
23. 
    weight gain
24. 
    yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

1. 
   Acid or sour stomach
2. 
   belching
3. 
   body aches or pain
4. 
   bone pain
5. 
   congestion
6. 
   cough
7. 
   diarrhea
8. 
   dryness or soreness of the throat
9. 
   feeling of indigestion
10. 
    general feeling of discomfort or illness
11. 
    heartburn
12. 
    hoarseness
13. 
    joint pain
14. 
    pain in the chest below the breastbone
15. 
    runny nose
16. 
    shivering
17. 
    sneezing
18. 
    stomach discomfort or upset
19. 
    stuffy nose
20. 
    sweating
21. 
    tender, swollen glands in the neck
22. 
    trouble sleeping
23. 
    trouble with swallowing
24. 
    voice changes

Rare

1. 
   Blistering, crusting, irritation, itching, or reddening of the skin
2. 
   bloated or full feeling
3. 
   blurred or loss of vision
4. 
   burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
5. 
   change in hearing
6. 
   cracked, dry, scaly skin
7. 
   decreased interest in sexual intercourse
8. 
   depression
9. 
   difficulty having a bowel movement (stool)
10. 
    disturbed color perception
11. 
    double vision
12. 
    ear drainage
13. 
    earache or pain in the ear
14. 
    excess air or gas in the stomach or intestines
15. 
    halos around lights
16. 
    hives or welts
17. 
    inability to have or keep an erection
18. 
    large, flat, blue or purplish patches in the skin
19. 
    loss in sexual ability, desire, drive, or performance
20. 
    night blindness
21. 
    overbright appearance of lights
22. 
    pain, swelling, or redness in the joints
23. 
    passing gas
24. 
    sleepiness or unusual drowsiness
25. 
    tunnel vision

Incidence not known

1. 
   Feeling of constant movement of self or surroundings
2. 
   sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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.

Irbesartan: medicine to treat high blood pressure

Take irbesartan tablets once a day.

Your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take irbesartan at any time of day. Try to take it at the same time every day.

You can take irbesartan tablets with or without food. Swallow the tablets whole with a drink of water.

How much will I take?

The dose of irbesartan you take depends on why you need the medicine. Take it as instructed by your doctor.

The usual dose is 150mg to 300mg once a day.

If you are over 75, or you have liver or kidney problems, your dose may be lower.

Will my dose go up or down?

After a few weeks your doctor will check your blood pressure and ask you if you’re getting any side effects. You may also have blood tests to check how well your kidneys are working and the amount of potassium in your blood. Your doctor will then decide whether to change your dose of irbesartan.

If irbesartan doesn’t get your blood pressure down, your doctor may want to increase the dose. If your blood pressure gets too low or you get side effects, your doctor may want to lower your irbesartan dose.

What if I get sick while I’m taking it?

If you get severe diarrhoea or vomiting for any reason, contact your doctor or a pharmacist. They’ll be able to advise you about what to do.

They may recommend that you stop taking irbesartan until you’re better, and you’re able to eat and drink normally again.

What if I forget to take it?

If you miss a dose of irbesartan, take it as soon as you remember. Do not take a double dose to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

If you take too many irbesartan tablets by accident, contact your doctor or go to your nearest hospital straight away. An overdose of irbesartan can cause low blood pressure and changes in heart rate.

The amount of irbesartan that can lead to an overdose varies from person to person.

Irbesartan tablets

What is this medicine?

IRBESARTAN (ir be SAR tan) is used to treat high blood pressure. This drug also slows down the progression of kidney disease in diabetic patients.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Avapro

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• heart failure
• kidney or liver disease
• an unusual or allergic reaction to irbesartan, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. This medicine can be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• diuretics, especially triamterene, spironolactone, or amiloride
• potassium salts or potassium supplements

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. Call your doctor or health care professional if you notice an irregular or fast heart beat.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child, particularly in the second or third trimester. Talk to your health care professional or pharmacist for more information.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• confusion, dizziness, light headedness or fainting spells
• decreased amount of urine passed
• difficulty breathing or swallowing, hoarseness, or tightening of the throat
• fast or irregular heart beat or palpitations
• swelling of your face, lips, tongue, hands, or feet
• unusual rash or hives

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• decreased sexual function
• diarrhea
• fatigue or tiredness
• heartburn

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Avapro (irbesartan) dosing, indications, interactions, adverse effects, and more

Irbesartan AN Tablets – NPS MedicineWise

What Irbesartan AN is used for

Irbesartan AN lowers high blood pressure, which doctors call hypertension.

Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) which means your blood pressure stays high, even when you are calm and relaxed.

There are often no symptoms of high blood pressure. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. High blood pressure, if not treated, can damage blood vessels in several organs such as the heart, the kidneys, the brain and the eyes. This may lead to heart attacks, heart or kidney failure, strokes, or blindness. There are usually no symptoms of high blood pressure before damage occurs, so your doctor needs to measure your blood pressure to see if it is too high.

High blood pressure can be treated and controlled with medicines such as Irbesartan AN. Your doctor may also have recommended that you adjust your lifestyle to help to lower your high blood pressure (losing weight, avoiding smoking, reducing alcohol consumption and restricting the amount of salt in the diet). Your doctor may also have encouraged the practice of regular, mild (not strenuous) exercise such as walking, swimming, etc.

Irbesartan AN is also used in the treatment of kidney disease in patients with high blood pressure and type 2 diabetes.

How Irbesartan AN works

Irbesartan AN belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which causes blood vessels to tighten. Irbesartan AN blocks angiotensin-II and therefore relaxes your blood vessels. This helps to lower your blood pressure.

Irbesartan AN slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Your doctor may have prescribed Irbesartan AN for another reason.

Ask your doctor if you have any questions about why Irbesartan AN has been prescribed for you.

Irbesartan AN is available only with a doctor’s prescription.

Before you take Irbesartan AN

When you must not take it

Do not take Irbesartan AN if:

• You are allergic to medicines containing irbesartan or any of the ingredients listed at the end of this leaflet.
• You are pregnant.
  Irbesartan AN may harm your developing baby if you take it during pregnancy.
• You are breastfeeding.
  It is not known if Irbesartan AN passes into breast milk, therefore it is recommended that you do not take it if you are breastfeeding.
• The expiry date on the pack has passed.
• The packaging is torn or shows signs of tampering.

Irbesartan AN should not be given to children.

Before you start to take it

Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives or any of the ingredients listed at the end of this leaflet, including lactose.

Tell your doctor if you are breastfeeding or wish to breastfeed.

Tell your doctor if you are pregnant or plan to become pregnant.

Tell your doctor if you have, or have had, any medical conditions, especially the following:

• kidney problems
• heart problems
• liver problems
• recent excessive vomiting or diarrhoea.

Tell your doctor if you are restricting salt intake in your diet.

Tell your doctor if you plan to have surgery (even at the dentist) that needs a general anaesthetic.

If you have not told your doctor about any of the above, tell them before you start taking Irbesartan AN.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may be affected by Irbesartan AN, or may affect how well it works. These include:

• other medicines for high blood pressure
• fluid tablets or diuretics
• lithium or lithium containing medicines (for example Lithicarb)
• potassium tablets (for example Span-K, Slow-K, Mag-K)
• potassium containing salt substitutes (for example Pressor-K)
• anti-inflammatory medicines, used to relieve pain, swelling and other symptoms of inflammation, including arthritis. These include nonsteroidal anti-inflammatory agents – NSAIDs (for example Voltaren, Indocid) and COX-2 inhibitors (for example Celebrex).

Taking a combination of Irbesartan AN with a thiazide diuretic (fluid tablet) and an anti-inflamatory medicine may damage your kidneys.

Your doctor can tell you what to do if you are taking any of these medicines.

If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Irbesartan AN.

How to take Irbesartan AN

How much to take

Your doctor will tell you how many tablets to take each day.

Usually patients start with one 150 mg tablet once a day.

However, some patients may need a lower starting dose. Your doctor will tell you if this is necessary. The full blood pressure lowering effect of Irbesartan-GA should be reached about 4-6 weeks after starting treatment.

Depending on how your blood pressure responds, your daily dose of Irbesartan AN may need to be increased. Most patients take either 150 mg or 300 mg each day.

In patients with high blood pressure and type 2 diabetes, 300 mg once daily is the preferred maintenance dose for slowing the progression of associated kidney disease

Follow all directions given to you by your doctor and pharmacist carefully. Ask your doctor or pharmacist if you are unsure of the correct dose for you.

How to take it

Swallow the tablets whole with a glass of water.

It does not matter whether you take Irbesartan AN tablets before or after food.

When to take it

Take Irbesartan AN at about the same time each day.

Taking your tablets at the same time each day will have the best effect. It will also help you remember when to take the tablets.

How long to take it

Continue taking Irbesartan AN until your doctor tells you to stop.

Irbesartan AN helps to control your high blood pressure, but it does not cure it. Therefore Irbesartan AN must be taken every day.

To help you remember to take your tablets each day, Irbesartan AN tablets are supplied in a Calendar pack with the foil backing marked with the days of the week. This is just a way to help you to remember to take your tablets. All of the tablets in the pack are the same.

When you start a new strip of tablets, take the tablet marked “START” at the end of the blister strip. On the next day, take the tablet marked with the relevant day of the week.

Continue taking your tablets each day until all of the tablets are taken. Commence the next strip at START and continue as before.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets as you would normally.

Do not take a double dose to make up for the dose you missed.

If you are not sure what to do, ask your doctor or pharmacist.

How long to take it for

Irbesartan AN helps control your high blood pressure but does not cure it. To properly control your condition, Irbesartan AN must be taken every day.

Keep taking Irbesartan AN for as long as your doctor recommends.

If you take too much Irbesartan AN (overdose)

Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Irbesartan AN. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.

If you take too much Irbesartan AN you may feel dizzy or lightheaded.

While you are taking Irbesartan AN

Things you must do

Before starting any new medicine, tell your doctor or pharmacist that you are taking Irbesartan AN.

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Irbesartan AN.

If you become pregnant while taking Irbesartan AN, tell your doctor immediately.

If you plan to have surgery, including dental surgery, that needs a general anaesthetic, tell your doctor or dentist that you are taking Irbesartan AN.

Visit your doctor regularly so they can monitor your blood pressure and ensure that Irbesartan AN is working for you.

Make sure you drink enough water during exercise and hot weather when you are taking Irbesartan AN.

If you do not drink enough water while taking Irbesartan AN, you may faint or feel lightheaded or sick. This is because your body does not have enough fluid and your blood pressure is low. If you continue to feel unwell, tell your doctor.

If you have excessive vomiting and/or diarrhoea while taking Irbesartan AN, tell your doctor.

You may lose too much water and salt and your blood pressure may drop too much.

If you feel lightheaded or dizzy after taking your first dose of Irbesartan AN, or when your dose is increased, tell your doctor immediately.

Things you must not do

Do not use Irbesartan AN to treat any other conditions unless your doctor tells you to.

Do not give Irbesartan AN to anyone else, even if they have the same condition as you.

Do not stop taking Irbesartan AN or lower the dose without checking with your doctor.

Things to be careful of

Be careful getting up from a sitting or lying position.

Dizziness, lightheadedness or fainting may occur, especially when you get up quickly. Getting up slowly may help. This problem can be more common if you are also taking a diuretic (fluid tablets). Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure.

Be careful driving or operating machinery until you know how Irbesartan AN affects you.

Irbesartan AN may cause drowsiness, dizziness or lightheadedness in some people. If any of these occur, do not drive, operate machinery or do anything else that could be dangerous.

If you drink alcohol, dizziness or lightheadedness may be worse.

Things that would be helpful for lowering your blood pressure:
Some self help measures suggested below may help your condition. Talk to your doctor of pharmacist about these measures and for more information.

1. Alcohol
   Your doctor may advise you to limit your alcohol intake.
2. Weight
   If you are overweight, your doctor may suggest losing some weight to help lower your blood pressure and help lessen the amount of work your heart has to do. Some people may need a dieticians help to lose weight.
3. Diet
   Your doctor may advise you to eat a healthy low-fat diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish.
4. Salt
   Your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt in cooking or at the table.
5. Exercise
   Regular exercise helps to reduce blood pressure and helps get the heart fitter, but it is important not to overdo it. Walking is good exercise, but try to find a route that is reasonably flat. Before starting any exercise, ask your doctor about the best kind of programme for you.
6. Smoking
   Your doctor may advise you to stop smoking or at least cut down.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Irbesartan AN.

Like all other medicines, Irbesartan AN may have unwanted side effects in some people. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects.

You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

• headache
• dizziness or lightheadedness (vertigo)
• unusual tiredness or weakness, fatigue
• nausea/vomiting

These are common side effects. They are generally mild and do not normally require treatment to be interrupted.

Tell your doctor immediately if you notice any of the following:

• skin rash or itchiness
• aching muscles or aching joints, not caused by exercise
• muscle pain or weakness
• buzzing, ringing or other persistent noise in the ears
• yellowing of the skin and/or eyes, also called jaundice
• symptoms that may indicate kidney disease, such as passing little or no urine, drowsiness, nausea, vomiting, breathlessness, loss of appetite and weakness
• symptoms that may indicate high potassium levels in the blood such as nausea, diarrhoea, muscle
• weakness and change in heart rhythm
• symptoms that may indicate liver disease such as nausea, vomiting, loss of appetite, feeling generally unwell, fever, itching, yellowing of the skin and eyes and dark coloured urine.

These are uncommon but serious side effects. Skin rash and itchiness may be symptoms of an allergic reaction. You may need medical attention.

If any of the following happen, stop taking Irbesartan AN and tell your doctor immediately, or go to Accident and Emergency at the nearest hospital:

• swelling to the face, lips, tongue or throat which may cause difficulty in swallowing or breathing
• severe and sudden onset of pinkish, itchy swellings on the skin, also called hives or nettlerash.

These are very rare but serious side effects. If you have them you have had a serious allergic reaction to Irbesartan AN. You may need urgent medical attention or hospitalisation.

Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything that is making you feel unwell.

After using Irbesartan AN

Storage

Keep your Irbesartan AN tablets in the blister pack until it is time to take them.

If you take the tablets out of the blister pack they may not keep well.

Keep Irbesartan AN where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep your tablets in a cool dry place where the temperature stays below 25°C.

Do not store Irbesartan AN or any other medicine in the bathroom or near a sink. Do not leave in the car or on window sills.

Heat and dampness can destroy some medicines.

Disposal

If your doctor tells you to stop taking Irbesartan AN, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

Irbesartan AN is presented in PVC/PVDC/Al blisters pack of 30 tablets.

• Irbesartan AN 75 mg tablets (AUST R 192795) – White to off-white, oval and biconvex tablet, debossed with “L172” on one side and “75” on the other side.
• Irbesartan AN 150 mg tablets (AUST R 192797) – White to off-white, oval and biconvex tablet, debossed with “L173” on one side and “150” on the other side
• Irbesartan AN 300 mg tablets (AUST R 192801) – White to off-white, oval and biconvex tablet, debossed with “L174” on one side and “300” on the other side.

Ingredients

Active ingredient
Irbesartan.

• each Irbesartan AN 75 mg tablet contains 75 mg of irbesartan
• each Irbesartan AN 150 mg tablet contains 150 mg of irbesartan
• each Irbesartan AN 300 mg tablet contains 300 mg of irbesartan.

The tablets also contain:

• Microcrystalline cellulose
• Lactose
• Croscarmellose sodium
• Povidone
• Magnesium stearate
• OPADRY II complete film coating system 30F58652 WHITE

Sponsor

Amneal Pharma Australia Pty Ltd
12 River St
South Yarra
Vic – 3141
Australia.

Date of preparation: June 2014

Apo-Irbesartan – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Irbesartan belongs to a family of medicines known as angiotensin II receptor blockers. These medicines are used to lower high blood pressure and work by relaxing blood vessels. Irbesartan is also used to lower blood pressure and decrease the rate of the progression of kidney damage for patients with type 2 diabetes.

Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Irbesartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to decrease. The full effects of irbesartan are usually seen within about 4 weeks. It can be used alone or in combination with thiazide diuretics (water pills; e.g., hydrochlorothiazide). 

This medication does not cure high blood pressure, but it does help to control it, when it is taken regularly. Do not stop taking this medication without discussing the risks and benefits with your doctor.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Apo-Irbesartan is no longer being manufactured for sale in Canada. For brands that may still be available, search under irbesartan. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

How should I use this medication?

The usual starting dose of irbesartan is 150 mg daily at approximately the same time each day. If you are taking other medication to reduce your blood pressure, your doctor may start you with a dose of 75 mg daily. The doctor may decide to increase the dose to 300 mg once a day if your blood pressure has not come down enough.

Irbesartan may be taken with or without food but should be taken in the same manner each day.

Make sure you follow your doctor’s instructions about monitoring your blood pressure to ensure that you receive the maximum benefit from the medication.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take irbesartan if you:

• are allergic to irbesartan or any ingredients of the medication
• have experienced a serious allergic reaction to another angiotensin II receptor blocker (ARB) (e.g., candesartan, losartan, valsartan)
• have diabetes mellitus, kidney damage caused by diabetes, or severely reduced kidney function and are taking the medication aliskiren or an angiotensin-converting enzyme (ACE) inhibitor
• are pregnant
• are breast-feeding
• have galactose intolerance or glucose malabsorption (a rare hereditary disease)

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• diarrhea
• dizziness
• drowsiness
• headache
• increased sensitivity of the skin to sunlight
• lightheadedness
• rash
• trouble sleeping
• unusual tiredness
• vomiting

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• back or leg pain, muscle cramps
• dizziness when rising from a sitting or lying position
• fainting
• fast heartbeat
• ringing in the ears
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of muscle damage (e.g., unexplained muscle pain, tenderness or weakness, or brown or discoloured urine)
• signs of too much potassium in the blood (e.g., muscle weakness, irregular heartbeat, general feeling of being unwell)
• swelling of the hands or feet
• symptoms of psoriasis flare up (e.g., painful, itchy skin, red patches, scales)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood sugar: Irbesartan can cause decreased levels of glucose in the blood. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication.

Drowsiness/reduced alertness: Irbesartan, like other medications for blood pressure, may cause dizziness and lightheadedness, especially if you have been taking a diuretic (water pill). This may affect your ability to drive or operate machinery. Avoid these and other activities until you have determined that this medication does not affect you in this way.

Heart disease: If you have a history of heart problems, such as a recent heart attack or stroke, narrowing of the heart valves (valvular stenosis) or other heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Irbesartan may affect the function of the kidneys, especially for people who already have kidney problems. Certain people may be more likely to experience changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills) or aliskiren may further increase risk of kidney problems for those at risk for this problem. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, a larger-than-expected decrease in blood pressure occurs after taking irbesartan. In some cases, this happens after the first dose. It is more likely to occur if you take diuretics (water pills) or the medication aliskiren, have a reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be monitored more often in these situations. If you have low blood pressure or are just starting to take this medication, move slowly from a reclining to an upright position to reduce the risk of dizziness.

Potassium levels: This medication may affect potassium levels in the blood, especially when used for heart failure, or when taken with other medications called ACE inhibitors or diuretics such as spironolactone. Your doctor will monitor your potassium levels while you are on this medication. Avoid using salt substitutes that contain potassium while you are taking irbesartan.

Pregnancy: Irbesartan can cause severe harm or death to a developing baby if it is taken by the mother during pregnancy. Therefore, this medication should not be taken by pregnant women. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if irbesartan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Older adults may be more likely to experience side effects of this medication.

What other drugs could interact with this medication?

There may be an interaction between irbesartan and any of the following:

• aldesleukin
• aliskiren
• alpha-agonists (e.g., clonidine, methyldopa)
• alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
• amifostine
• amiodarone
• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
• angiotensin converting enzyme (ACE) inhibitors (e.g., captopril, ramipril, enalapril)
• antipsychotics (e.g., aripiprazole, clozapine, olanzapine, pimozide)
• apomorphine
• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• brimonidine
• calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
• celecoxib
• conivaptan
• cyclosporine
• dexmethylphenidate
• diabetes medications (e.g., canagliflozin, glyburide, insulin, linagliptin, lixisenatide, metformin, rosiglitazone)
• digoxin
• diuretics (water pills; e.g., hydrochlorothiazide, furosemide)
• drospirenone
• duloxetine
• eplerenone
• ginger
• guanfacine
• ginseng (American)
• heparin
• hydralazine
• isosorbide dinitrate or isosorbide mononitrate
• levodopa
• lithium
• low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
• methylphenidate
• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
• nabilone
• nonsteroidal anti-inflammatory medications (e.g., diclofenac, ibuprofen, ketoprofen, naproxen)
• other angiotensin receptor blockers (ARBs; e.g., candesartan, losartan)
• paclitaxel
• pentoxifylline
• phenobarbital
• phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
• potassium pills or potassium supplements
• potassium-sparing diuretics (e.g., amiloride, spironolactone, triamterene)
• pramipexole
• quinine
• riociguat
• ropinirole
• rotigotine
• sacubitril
• salt substitutes that contain potassium
• sodium phosphates
• sulfonamide antibiotics (e.g., sulfamethoxazole, sulfisoxazole)
• tacrolimus
• tizanidine
• tolvaptan
• tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
• trimethoprim
• yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Apo-Irbesartan

Irbesartan, an angiotensin receptor blocker. Aprovel, Ifirmasta

About irbesartan

Irbesartan is an angiotensin receptor blocker. It is also called an angiotensin-II receptor antagonist, or an AIIRA. It is used to treat high blood pressure (hypertension). People with high blood pressure usually do not feel unwell, but if left untreated, high blood pressure can harm the heart and damage blood vessels.

Irbesartan works by blocking the effect of a chemical called angiotensin II. Angiotensin II causes your blood vessels to narrow, so by blocking its effect, irbesartan allows your blood vessels to relax and widen. As this happens, the pressure within your blood vessels is reduced. Irbesartan also has a protective function on the kidneys of people with type 2 diabetes who have high blood pressure.

Irbesartan may be prescribed on its own to treat high blood pressure, or you may also be given other medicines to take alongside it. This is because a combination of medicines which work in different ways can often lower your blood pressure more than one medicine on its own. One brand of tablet called CoAprovel® contains hydrochlorothiazide as well as irbesartan – being prescribed a combination brand like this will help to reduce the number of tablets you need to take each day.

Before taking irbesartan

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking irbesartan it is important that your doctor knows:

• If you are pregnant, trying for a baby or breastfeeding.
• If you have a problem with your kidneys, particularly if it is a blockage of the artery which supplies blood to your kidneys.
• If you have any problems with your heart valves or heart muscle.
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
• If you have ever had an allergic reaction to a medicine.

How to take irbesartan

• Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about irbesartan and will provide you with a full list of the side-effects which you may experience from taking it.
• Take irbesartan once each day, exactly as your doctor tells you to. There are several different strengths of tablet available (75 mg, 150 mg and 300 mg) – your doctor will tell you which strength of tablet is right for you.
• Try to take irbesartan at the same time of day each day. This will help you to remember to take your doses regularly.
• Swallow the tablet with a drink of water. You can take irbesartan before or after meals.
• If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, miss out the forgotten dose. Do not take two doses at the same time to make up for a forgotten dose.

Getting the most from your treatment

• Try to keep your regular appointments with your doctor. This is so your progress can be monitored and your blood pressure measured. Your doctor may want you to have some blood tests from time to time to check on your kidneys, and also on how much potassium is in your blood.
• Each time you collect a prescription, check to make sure it is the strength of tablet that you are expecting.
• If you buy any medicines, check with a pharmacist that they are suitable to take with irbesartan. This is because some anti-inflammatory painkillers (such as aspirin and ibuprofen) may interfere with the way it works, and also may increase the risk of side-effects.
• It is very important that you follow any dietary and lifestyle advice that you may have been given by your doctor, such as eating a healthy diet, not smoking, and taking regular exercise.
• If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on irbesartan because it will increase the risk of side-effects, such as feeling dizzy or faint.
• Try to avoid salt substitutes which contain potassium. This is because the substitutes will increase the amount of potassium in your blood and this can cause problems.
• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking irbesartan. This is because your blood pressure may drop too low if you are given some anaesthetics.
• Treatment with irbesartan is usually long-term unless you experience an adverse effect. Continue to take the tablets regularly, unless you are advised otherwise by your doctor.

If you are also taking hydrochlorothiazide in combination with this medicine

• Studies have suggested that taking higher doses of hydrochlorothiazide for long periods of time may increase the risk of certain skin cancers.
• Tell your doctor if you have ever been treated for skin cancer before.
• Tell your doctor about any new or changed moles or worrying marks on your skin.
• Use a sunscreen in strong sunlight. Do not use sunbeds.

Can irbesartan cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with irbesartan. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: irbesartan has been associated with an allergic-type reaction in a few people. Although this occurs only rarely, if you get any swelling of your mouth or face, speak with your doctor or go to your local accident and emergency department straightaway.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice. 

How to store irbesartan

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ^® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

Trade names: USA

Avapro

Trade names: Canada

ACT Irbesartan [DSC]; AG-Irbesartan; APO-Irbesartan; Auro-Irbesartan; Avapro; BIO-Irbesartan; DOM-Irbesartan [DSC]; JAMP-Irbesartan; MINT-Irbesartan; MYLAN-Irbesartan [DSC]; PMS-Irbesartan; Priva-Irbesartan; RIVA-Irbesartan [DSC]; SANDOZ Irbesartan; TARO-Irbesartan; TEVA-Irbesartan; VAN-Irbesartan [DSC]

Warning

• Not for use by pregnant women.The use of the drug during pregnancy can cause birth defects or intrauterine death of the child. If you become pregnant or plan to become pregnant while taking this drug, call your doctor right away.

What is this drug used for?

• Used to treat high blood pressure.
• Used to protect kidney function in diabetic patients with low protein levels.
• This medicinal product may be used for other indications.Check with your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.
• If you are taking a drug containing aliskiren if you have diabetes or kidney disease.
• If you are breastfeeding. Do not breast-feed while taking this drug.

This list of drugs and diseases that may be adversely associated with this drug is not exhaustive.

Tell your doctor and pharmacist about all the medicines you take (prescription and over-the-counter, natural products and vitamins) and your health problems. You need to make sure that this drug is safe for your medical condition and in combination with other drugs you are already taking.Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

• Tell all healthcare providers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• To reduce the risk of dizziness or loss of consciousness, get up slowly from a lying or sitting position. Use caution when going up and down stairs.
• Check blood pressure as directed.
• Perform blood tests as directed by your healthcare practitioner. Please consult your doctor.
• If you are using a salt substitute containing potassium, a potassium-sparing diuretic, or a potassium supplement, consult your doctor.
• Consult your doctor if you are on a salt-free or low-salt diet.
• If you are taking this drug and have high blood pressure, talk to your doctor before taking any over-the-counter drugs that can raise blood pressure. These drugs include medicines for coughs and colds, diet pills, stimulants, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, and some naturally occurring drugs.
• Consult a physician before drinking alcohol.
• Exercise caution in hot weather and during vigorous activity. Drink plenty of fluids to stay hydrated.
• Tell your doctor if you experience excessive sweating, fluid loss, vomiting, or loose stools. This can lead to a drop in blood pressure.
• The ability of this drug to lower blood pressure may be less pronounced in Blacks.In some cases, you may need to take another drug at the same time in addition to this drug. If you have any questions, please consult your doctor.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can have serious and sometimes deadly side effects. Call your doctor right away or get medical help if you have any of the following signs or symptoms, which may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, reddened and swollen skin with blisters or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
• Signs of kidney problems, including lack of urination, change in urine volume, blood in the urine, or rapid weight gain.
• Signs of elevated potassium levels such as a feeling of disturbed heartbeat, confusion, feeling weak or dizzy, feeling light-headed, feeling numb or tingling, or shortness of breath.
• Severe dizziness or fainting.

What are some other side effects of this drug?

Any medicine can have side effects.However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

• Dizziness.

This list of potential side effects is not comprehensive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you. Follow all instructions strictly.

• Take this medication with or without food.
• Take this drug at about the same time of the day.
• Continue taking this drug as directed by your doctor or other healthcare professional, even if you feel well.
• Drink plenty of decaffeinated fluids, unless your doctor tells you to drink less fluids.

What should I do if a dose of a drug is missed?

• Take the missed dose as soon as you can.
• If it’s time to take your next dose, do not take the missed dose and then return to your normal dose.
• Do not take 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs.Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. There may be drug recycling programs in your area.

General information on medicinal products

• If your health does not improve or even worsens, see your doctor.
• You should not give your medicine to anyone and take other people’s medicines.
• Some medicines may come with other patient information sheets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• Some medicines may come with other patient information sheets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Use of information by consumer and limitation of liability

This summary information includes a summary of the diagnosis, treatment, and / or drug. It is not a comprehensive data source and should be used as a tool to help the user understand and / or evaluate potential diagnostic and treatment options.It does NOT include all information about conditions, treatments, medications, side effects or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult a physician for complete information about their health, medical issues and treatment options, including any risks or benefits in relation to the use of the medication.This information does not guarantee that a treatment or drug is safe, effective, or approved for specific patients. UpToDate, Inc. and its subsidiaries disclaim any warranties or obligations related to this information or its use. Use of this information is governed by the Terms of Use found at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Copyright

© UpToDate, Inc.and its affiliates and / or licensors, 2021. All rights reserved.

90,000 What are the common side effects of Irbesartan?

Irbesartan is a drug commonly used to treat high blood pressure and most patients do not experience any of the side effects of irbesartan. The most common irbesartan side effects, when present, include relatively mild conditions such as heartburn, diarrhea, dizziness, fatigue, and sore throat.More serious side effects, such as fainting, swelling, hives, sexual impairment, yellowing of the skin or eyes, and pain while urinating, are possible but uncommon and require immediate medical attention.

This drug is available as a prescription to treat high blood pressure, either by itself or with other blood pressure medications. Irbesartan lowers blood pressure by relaxing the blood vessels, causing them to dilate. Doctors may also prescribe irbesartan to diabetic patients to protect the kidneys from damage.

Most patients can take the drug without any side effects of irbesartan. Diarrhea is the most common side effect, affecting about one in every 30 patients. Heartburn and stomach discomfort are also relatively common, affecting one in 50 patients. Other mild irbesartan side effects include dizziness, blurred vision, fatigue, mild anxiety, runny nose, and joint pain. If any of these problems persist or get worse, consultation with your doctor is recommended.

Serious side effects of irbesartan are much less common and can be dangerous. Patients should advise their prescribing physician of any allergies, especially noting known allergies to angiotensin-converting enzyme (ACE) inhibitors. Severe allergic reactions can be life-threatening if the throat swells and obstructs the airways. If a patient experiences symptoms such as hives, swelling, or shortness of breath, immediate medical attention is needed.

Other serious side effects of irbesartan include changes in the amount and color of the patient’s urine, loss of consciousness, decreased sexual performance, or a yellow tinge to the skin or eyes. Each of these conditions is extremely rare, but when present, it poses a serious threat to the patient’s well-being. The physician must be immediately notified of any of these conditions. Patients can prevent these irbesartan side effects by informing their doctor about any serious current or previous medical condition, especially liver or kidney disease or dysfunction, severe dehydration, or high blood potassium levels.

Pregnant and lactating women should not take irbesartan. Irbesartan can be very dangerous – even fatal – for unborn babies. Women must use a reliable form of birth control while taking the drug. Any woman who is taking irbesartan should consult her doctor before trying to get pregnant.

OTHER LANGUAGES

Avapro (Irbesartan) Side effects, images, use, dosage, overdose in RxList

• Generic Name: Irbesartan
• Brand Name: Avapro

Information for Avapro Patients, Including Side Effects

Names: Avapro

Generic Name: Irbesartan

What is Irbesartan (Avapro)?

Irbesartan is an angiotensin II receptor antagonist.Irbesartan prevents narrowing of blood vessels, which lowers blood pressure and improves blood flow.

Irbesartan is used to treat high blood pressure (hypertension). It is sometimes prescribed along with other blood pressure medications.

Irbesartan is also used to treat kidney problems caused by type 2 diabetes.

Irbesartan may also be used for purposes not listed in this medication guide.

What are the possible side effects of irbesartan (Avapro)?

Get emergency medical help if you have signs of an allergic reaction: hives; labored breathing; swelling of your face, lips, tongue, or throat.

In rare cases, irbesartan can cause a condition that leads to the destruction of skeletal muscle tissue, leading to renal failure. Call your doctor right away if you experience unexplained muscle pain, tenderness, or weakness, especially if you also have a fever, unusual tiredness, and dark urine.

Call your doctor at once if you have:

• feeling dizzy, as if you could pass out;
• little or no urination;
• edema, rapid weight gain; or
• confusion, loss of appetite, vomiting, pain in the side or lower back.

Common side effects may include:

• diarrhea;
• heartburn, indigestion; or
• feeling tired.

This is not a complete list of side effects and they can arise. Ask your doctor about side effects. You can report side effects to the FDA by calling 1-800-FDA-1088.

What is the most important information I should know about irbesartan (Avapro)?

Do not use if you are pregnant. Stop use and tell your doctor right away if you become pregnant.

If you have diabetes Do not use irbesartan with any medicine containing aliskiren (blood pressure medicine).

Information for Avapro Patients, including information on how to take

What should I discuss with my healthcare provider before taking irbesartan (Avapro)?

You should not use irbesartan if you are allergic to it.

If you have diabetes, Do not use irbesartan with any medicine containing aliskiren (blood pressure medicine).

You may also need to avoid taking irbesartan with aliskiren. if you have kidney disease.

Tell your doctor if you have ever had:

• kidney disease;
• liver disease;
• chronic heart failure; or
• if you are dehydrated.

Do not use if you are pregnant and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to an unborn child if you take the medicine in the second or third trimester.

You should not breastfeed while using this medication.

How should I take irbesartan (Avapro)?

Follow all directions on the prescription label and read all medication guides or directions. Your doctor may change your dose from time to time. Use the medicine exactly as directed.

Irbesartan can be taken with or without food.

Your blood pressure will need to be checked frequently.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure is often asymptomatic. You may need to take blood pressure medications for the rest of your life.

Store at room temperature away from moisture and heat.

Information for Avapro Patients, Including Missed Dose

What happens if I miss a dose (Avapro)?

Take your medicine as soon as possible, but skip the missed dose if it is almost time for your next dose. Do not take two doses at a time.

What happens if I overdose (Avapro)?

in what doses lexapro is included

Seek emergency medical attention or call the Poison Helpline at 1-800-222-1222.

What should I avoid while taking irbesartan (Avapro)?

Drinking alcohol can further lower blood pressure and may increase some of the side effects of irbesartan.

Do not use potassium supplements or salt substitutes unless your doctor has told you to.

Do not get up too quickly from a sitting or lying position, or you may feel dizzy.

What other drugs will affect irbesartan (Avapro)?

Tell your doctor about all of your other medicines, especially:

This list is not complete. Other drugs may affect irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get additional information (Avapro)?

Your pharmacist can provide more information about irbesartan.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only as directed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. is accurate, up-to-date and complete. (“Multum”), but no guarantees are given. The information contained herein about the drug may vary over time. Multum’s information has been collected for use by medical practitioners and consumers in the United States, and therefore Multum does not warrant that use outside the United States is appropriate unless specifically noted otherwise.Multum’s drug information does not contain recommendations for drugs, patient diagnosis, or treatment. Multum’s Drug Information is an information resource designed to help licensed medical practitioners care for their patients and / or serve consumers who see this service as an addition to the experience, skills, knowledge and judgment of medical practitioners, not a replacement. The absence of a warning for a given drug or drug combination should in no way be construed as an indication that the drug or drug combination is safe, effective, or appropriate for any given patient.Multum assumes no responsibility for any aspect of health care that is controlled by the information provided by Multum. The information contained in this document is not intended to cover all possible uses, indications, precautions, warnings, drug interactions, allergic reactions or side effects. If you have questions about any medications you are taking, ask your doctor, nurse, or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc.